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neonatology, newborn, preterm, ROP

Deepak Sharma
"Golden Hour" of neonatal life is defined as the first hour of post-natal life in both preterm and term neonates. This concept in neonatology has been adopted from adult trauma where the initial first hour of trauma management is considered as golden hour. The "Golden hour" concept includes practicing all the evidence based intervention for term and preterm neonates, in the initial sixty minutes of postnatal life for better long-term outcome. Although the current evidence supports the concept of golden hour in preterm and still there is no evidence seeking the benefit of golden hour approach in term neonates, but neonatologist around the globe feel the importance of golden hour concept equally in both preterm and term neonates...
2017: Maternal Health, Neonatology and Perinatology
Paolo Manzoni, Luigi Memo, Michael Mostert, Elena Gallo, Roberta Guardione, Andrea Maestri, Onofrio Sergio Saia, Anna Opramolla, Sara Calabrese, Elena Tavella, Martina Luparia, Daniele Farina
BACKGROUND: Retinopathy of prematurity (ROP) is a multifactorial disease with evidence of many associated risk factors. Erythropoietin has been reported to be associated with this disorder in a murine model, as well as in humans in some single-center reports. We reviewed the data from two large tertiary NICUs in Italy to test the hypothesis that the use of erythropoietin may be associated with the development of the most severe stages of ROP in extremely low birth weight (ELBW) neonates...
September 2014: Early Human Development
Qing Liu, Zheng-Qin Yin, Ning Ke, Lin Chen, Xin-Ke Chen, Jing Fang, Xiu-Rong Chen, Jun Xiao, Kang Hu, Xuan Zhang, Yan Xiong, Hui Shi, Jie Li, Hong-Jian Long, Kang-Lin Zhang, Zhi-Yu Chen, Lian-Hong Pi
BACKGROUND: The aim of this study was to screen for retinopathy of prematurity (ROP) in southwestern China and understand the prevalence and risk factors of ROP, which may provide evidence useful in the prevention and treatment of ROP. MATERIAL/METHODS: 1864 preterm infants (gestational age of <37 weeks and birth weight of ≤2500 g) underwent ROP screening from January 2009 to November 2012 in Southwest China. The medical information of infants during perinatal period was reviewed, and risk factors of ROP were determined...
2014: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
Clare Gilbert, Brian Darlow, Andrea Zin, Selvaraj Sivasubramaniam, Shaheen Shah, Nicole Gianini, Gina Beecroft, Maria Elisabeth Lopes Moreira
BACKGROUND: Preterm birth contributes significantly to infant mortality and morbidity, including blindness from retinopathy of prematurity (ROP). Access to intensive neonatal care is expanding in many countries, but care is not always optimal, one factor being that nursing is often by inadequately trained nurse assistants. OBJECTIVE: The aim of this study was to evaluate whether an educational package for nurses improves a range of outcomes including survival rates and severe ROP in 5 neonatal units in Rio de Janeiro, Brazil...
2014: Neonatology
Neena Modi
Evidence-based medicine has been embraced wholeheartedly, and rightly so, as the best approach for reducing clinical uncertainty and ensuring that patients receive treatment and care that are efficacious (i.e. they work) and effective (i.e. they work in real life). High-quality evidence comes from high-quality clinical research. It would hence be reasonable to assume that these two would form a closely integrated partnership. Alas, this is not yet the case. So many uncertainties in medical care relate to treatments and practices already widely in use...
2014: Neonatology
Prakesh S Shah, Shoo K Lee, Kei Lui, Gunnar Sjörs, Rintaro Mori, Brian Reichman, Stellan Håkansson, Laura San Feliciano, Neena Modi, Mark Adams, Brian Darlow, Masanori Fujimura, Satoshi Kusuda, Ross Haslam, Lucia Mirea
BACKGROUND: The International Network for Evaluating Outcomes in Neonates (iNeo) is a collaboration of population-based national neonatal networks including Australia and New Zealand, Canada, Israel, Japan, Spain, Sweden, Switzerland, and the UK. The aim of iNeo is to provide a platform for comparative evaluation of outcomes of very preterm and very low birth weight neonates at the national, site, and individual level to generate evidence for improvement of outcomes in these infants. METHODS/DESIGN: Individual-level data from each iNeo network will be used for comparative analysis of neonatal outcomes between networks...
April 23, 2014: BMC Pediatrics
Eloisa Gitto, Lucia Marseglia, Sara Manti, Gabriella D'Angelo, Ignazio Barberi, Carmelo Salpietro, Russel J Reiter
Oxidative stress contributes to the severity of several newborn conditions to the extent that Saugstad coined the phrase "oxygen radical diseases of neonatology." In order to counteract free radicals damage many strategies to augment antioxidant status in ill-term and preterm infants have been proposed and several medications have been experimented with mixed results. Several studies have tested the efficacy of melatonin to counteract oxidative damage in diseases of newborns such as chronic lung disease, perinatal brain injury, necrotizing enterocolitis, and retinopathy of prematurity, giving promising results...
2013: Oxidative Medicine and Cellular Longevity
Krishna A Rao, Jayashree Purkayastha, Manali Hazarika, Raghuvamsi Chaitra, K Mithun Adith
CONTEXT: Recent advances in neonatology have influenced the incidence and severity of ROP in a dichotomous fashion. AIMS: To determine the incidence of ROP and to analyse its risk factors. SETTINGS AND DESIGN: Prospective clinical case series. MATERIALS AND METHODS: 282 preterm infants with birthweight < 1500 g and/or gestational age ≤ 32 weeks and also those with gestational age > 32 weeks, with birthweight between 1500-2000 g, who were at risk for ROP were selected...
November 2013: Indian Journal of Ophthalmology
Paolo Manzoni, Ilaria Stolfi, Roberto Pedicino, Federica Vagnarelli, Fabio Mosca, Lorenza Pugni, Lina Bollani, Margherita Pozzi, Kelly Gomez, Chryssoula Tzialla, Alessandro Borghesi, Lidia Decembrino, Michael Mostert, Maria Agnese Latino, Claudio Priolo, Paolo Galletto, Elena Gallo, Stefano Rizzollo, Elena Tavella, Martina Luparia, Giuseppina Corona, Ignazio Barberi, Elisabetta Tridapalli, Giacomo Faldella, Gennaro Vetrano, Luigi Memo, Onofrio Sergio Saia, Linda Bordignon, Hubert Messner, Silvia Cattani, Elena Della Casa, Nicola Laforgia, Michele Quercia, Mario Romeo, Pasqua Maria Betta, Matteo Rinaldi, Rosario Magaldi, Milena Maule, Mauro Stronati, Daniele Farina
BACKGROUND: Retinopathy of prematurity (ROP) is a multifactorial disease, but little is known about its relationships with neonatal nutritional policies. Human, maternal milk is the best possible nutritional option for all premature infants, including those at high risk for severe complications of prematurity, such as ROP. OBJECTIVE: This is a secondary analysis of data collected during two multicenter RCTs performed consecutively (years 2004 through 2008) by a network of eleven tertiary NICUs in Italy...
June 2013: Early Human Development
Zelal Kahramaner, Sumer Sutcuoglu, Ebru Cicek, Aydin Erdemir, Hese Cosar, Ebru Turkoglu, Ayfer Colak, Esra Arun Ozer
OBJECTIVE: To investigate the relation between serum homocysteine levels and intraventricular hemorrhage (IVH) in preterm infants born to preeclamptic mothers. METHOD: This study included 84 preterm infants (42 born to preeclamptic mothers and 42 born to normotensive healthy mothers) who were admitted to Izmir Tepecik Training and Research Hospital Neonatology Clinic on the postnatal first day. The measurement of homocysteine levels in all samples were performed with an Immulite 2000 analyzer, using the chemiluminescence method...
December 2013: Journal of Maternal-fetal & Neonatal Medicine
Lidija Banjac, Vesna Bokan
The aim of our study was to measure and compare serum insulin-like growth factor-1 (IGF-1) levels at postmenstrual age of 33 weeks between preterm infants with and without retinopathy of prematurity (ROP). ROP occurs in two phases. Low serum levels of IGF-1 during ROP phase 1 have been found to correlate with the severity of ROP. ROP phase 2 begins around postmenstrual week 33. We conducted a prospective cohort study to measure serum IGF-1 levels in premature infants at postmenstrual age of 33 weeks. The study included all premature infants (N = 74), gestational age < or = 33 weeks, hospitalized at Department of Neonatology, Clinical Center of Montenegro, from April 2008 to July 2009...
June 2012: Acta Clinica Croatica
Sanja Knezevic, Nadezda Stojanović, Ana Oros, Jasmina Knezević
BACKGROUND/AIM: Retinopathy of prematurity (ROP) is a multifactorial disease in premature infants. The aim of this study was to determine the incidence of ROP in children treated at the Center of Neonatology, Pediatric Clinic, Clinical Center in Kragujevac, Serbia. METHODS: The study covered all children with birth weight below 2,000 g and/or gestational age below the 37th week, who from June 2006 to December 2009 underwent ophthalmological examination for ROP. The results of fundoscopy were classified in accordance with the International Classification of ROP...
September 2012: Vojnosanitetski Pregled. Military-medical and Pharmaceutical Review
Magdalena Miedzińska, Grazyna Hnatyszyn, Halina Konefał, Małgorzata Hernicka-Stawiarska, Monika Modrzejewska, Anna Kabacińska, Maria Beata Czeszyńska
UNLABELLED: The aim of this study was to determine the relationship between meningitis and neonatal period of complications such as massive intraventricular hemorrhage and into brain tissue, hypoxic-ischemic white matter injury retinopathy of prematurity 3-5 degrees and deafness in infants born prematurely from single and multiple pregnancies. MATERIAL: The retrospective study covered 460 preterm infants born to single pregnancies and 280 infants born prematurely with multiple pregnancies, hospitalized in the Clinic of Neonatology PUM in the years: 2005-2008...
March 2012: Ginekologia Polska
Brian A Darlow, Anna L Ells, Clare E Gilbert, Glen A Gole, Graham E Quinn
The publication of the BEAT-ROP study of bevacizumab (Avastin) treatment for Zone I and II retinopathy of prematurity (ROP) has raised hopes that there might now be a simpler, cheaper and more effective treatment than laser therapy, the current standard of care. However, we would urge caution at this point in time. We review the scientific background to the use of intravitreal anti-vascular endothelial growth factor for ROP, highlight a number of design issues in the BEAT-ROP study and problems with interpretation of the results...
March 2013: Archives of Disease in Childhood. Fetal and Neonatal Edition
Sanja Knezević, Nadezda Stojanović, Ana Oros, Dragana Savić, Aleksandra Simović, Jasmina Knezević
INTRODUCTION: Retinopathy of prematurity (ROP) is a multifactorial disease that occurs most frequently in very small and very sick preterm infants, and it has been identified as the major cause of childhood blindness. OBJECTIVE: The aim of this study was to evaluate ROP incidence and risk factors associated with varying degrees of illness. METHODS: The study was conducted at the Centre for Neonatology, Paediatric Clinic of the Clinical Centre Kragujevac, Serbia, in the period from June 2006 to December 2008...
July 2011: Srpski Arhiv za Celokupno Lekarstvo
Philipp S Muether, Angela Kribs, Moritz Hahn, Jasmin Schumacher, Frank Eifinger, Bernd Kirchhof, Bernhard Roth, Sascha Fauser
BACKGROUND: Retinopathy of prematurity (ROP) remains a major cause of juvenile blindness. As screening recommendations are refined, decreasing gestational age (GA) and birth weight (BW) constitute an increasing risk for ROP. This retrospective case series reviews the screening results of a very immature cohort in Germany. METHODS: We conducted ROP screening according to the German guidelines of 1999: all preterm infants with a GA of < 32 weeks and/or a BW of < 1501 g, or with GA ≥ 32 weeks and postnatal oxygen treatment for > 3 days, were assigned for screening...
March 2012: British Journal of Ophthalmology
S Flückiger, H U Bucher, A Hellström, C Lövqist, V Sturm, S J Arri
BACKGROUND: Premature infants are often stressed by the current retinopathy of prematurity (ROP) screening procedure. Additionally, only < 10 % of the screened infants will develop a ROP stadium requiring laser therapy. Therefore the present screening strategy is unsatisfactory. Furthermore, the current guidelines do not take into account postnatal factors. A new method considering postnatal factors is the weight, insulin-like growth factor, neonatal ROP (WINROP) algorithm. This approach is based on the early postnatal weight gain...
April 2011: Klinische Monatsblätter Für Augenheilkunde
Krystal Johnson, Shannon D Scott, Kimberly D Fraser
Preterm infants in neonatal intensive care units frequently require oxygen therapy. Clinicians are responsible for titrating oxygen to maximize the benefits and minimize the risks of this therapy. Studies have identified various toxic effects of oxygen on the developing tissues of the preterm infant; however, optimal target SpO(2) ranges have not been identified. Current trends in neonatology are focusing on defining optimal oxygen saturation ranges to improve infant outcomes and to decrease complications associated with the oxygen use...
February 2011: Advances in Neonatal Care: Official Journal of the National Association of Neonatal Nurses
Gabriela Zaharie, Simona Tălu, Claudia Stefănut, Cristina Vlăduţiu, Monica Popa, Liana Kudor Szbadi
PURPOSE: The study aims to evaluate the ROP, the factors that influence this disease in very low birth weight newborns that are included in the neonatal screening program. MATERIAL AND METHOD: It is a retrospective study performed on 82 preterm newborns managed by The Neonatology Department of Obstetrics and Gynecology Clinic I from Cluj over a period of 15 months. There were assessed: prenatal factors, birth, perinatal pathology, therapy received, incidence of ROP and the necessity for laser therapy The statistical analysis has been performed in Epi 6...
2007: Oftalmologia
P Lago, G Ancora, C V Bellieni, A Cavazza, G Cocchi, A M Guadagni, L Memo, D Merazzi, A Pirelli
OBJECTIVE: Despite accumulating evidence that procedural pain experienced by preterm infants may have acute detrimental and even long-term effects on an infant's subsequent behavior and neurological outcome, neonates admitted to Neonatal Intensive Care Units still frequently experience acute and prolonged uncontrolled pain. Many invasive and surgical procedures are routinely performed at the bedside in the NICU without adequate pain management. AIM: To develop evidence-based guidelines and recommendations for pain control and prevention in Italian i...
2006: La Pediatria Medica e Chirurgica: Medical and Surgical Pediatrics
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