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https://www.readbyqxmd.com/read/29745328/non-fatal-overdose-with-u-47700-identification-in-biological-matrices
#1
Susanna Vogliardi, Giulia Stocchero, Sergio Maietti, Marianna Tucci, Alessandro Nalesso, Rossella Snenghi, Donata Favretto
BACKGROUND/OBJECTIVE: We report on a case of severe intoxication after insufflation of U- 47700, a synthetic opioid that acts as a selective agonist of the μ-opioid receptor, and is several times more potent than morphine. A man in his 30s was found irresponsive in his apartment and was brought to the emergency department of a local hospital. A comatose state and severe respiratory depression were present. Hetero anamnesis revealed that the patient could have taken the substance named “U- 47700”, bought on the Internet...
May 9, 2018: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/29689453/cross-talk-of-cannabinoid-and-endocannabinoid-metabolism-is-mediated-via-human-cardiac-cyp2j2
#2
William R Arnold, Austin T Weigle, Aditi Das
Phytocannabinoids have well-known cardiovascular implications. For instance, Δ9-tetrahydrocannabinol (Δ9-THC), the principal component of cannabis, induces tachycardia in humans. In order to understand the impact of phytocannabinoids on human cardiovascular health, there is a need to study the metabolism of phytocannabinoids by cardiac cytochromes p450 (CYPs). CYP2J2, the primary CYP of cardiomyocytes, is responsible for the metabolism of the endocannabinoid, anandamide (AEA), into cardioprotective epoxides (EET-EAs)...
April 7, 2018: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/29453097/self-assembled-vertically-aligned-au-nanorod-arrays-for-surface-enhanced-raman-scattering-sers-detection-of-cannabinol
#3
Sarah Milliken, Jeff Fraser, Shawn Poirier, John Hulse, Li-Lin Tay
Self-assembled multi-layered vertically aligned gold nanorod (AuNR) arrays have been fabricated by a simple preparation process that requires a balance between the particle concentration and the ionic strength of the solvent. An experimentally determined critical AuNR concentration of 2.0nM and 50mM NaCl produces well-ordered vertically aligned hexagonally close-packed AuNR arrays. We demonstrate surface treatment via UV Ozone cleaning of such samples to allow introduction of analyte molecules (benzenethiol and cannabinol) for effective surface enhanced Raman scattering detection...
May 5, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29359294/detection-and-quantification-of-cannabinoids-in-extracts-of-cannabis-sativa-roots-using-lc-ms-ms
#4
Waseem Gul, Shahbaz W Gul, Suman Chandra, Hemant Lata, Elsayed A Ibrahim, Mahmoud A ElSohly
A liquid chromatography-tandem mass spectrometry single-laboratory validation was performed for the detection and quantification of the 10 major cannabinoids of cannabis, namely, (-)- trans -Δ9 -tetrahydrocannabinol, cannabidiol, cannabigerol, cannabichromene, tetrahydrocannabivarian, cannabinol, (-)- trans -Δ8 -tetrahydrocannabinol, cannabidiolic acid, cannabigerolic acid, and Δ9 -tetrahydrocannabinolic acid-A, in the root extract of Cannabis sativa . Acetonitrile : methanol (80 : 20, v/v) was used for extraction; d3 -cannabidiol and d3 - tetrahydrocannabinol were used as the internal standards...
March 2018: Planta Medica
https://www.readbyqxmd.com/read/29262425/quantitative-determination-of-%C3%AE-9-thc-cbg-cbd-their-acid-precursors-and-five-other-neutral-cannabinoids-by-uhplc-uv-ms
#5
Yan-Hong Wang, Bharathi Avula, Mahmoud A ElSohly, Mohamed M Radwan, Mei Wang, Amira S Wanas, Zlatko Mehmedic, Ikhlas A Khan
Cannabinoids are a group of terpenophenolic compounds in the medicinal plant Cannabis sativa (Cannabaceae family). Cannabigerolic acid, Δ9 -tetrahydrocannabinolic acid A, cannabidiolic acid, Δ9 -tetrahydrocannabinol, cannabigerol, cannabidiol, cannabichromene, and tetrahydrocannabivarin are major metabolites in the classification of different strains of C. sativa . Degradation or artifact cannabinoids cannabinol, cannabicyclol, and Δ8 -tetrahydrocannabinol are formed under the influence of heat and light during processing and storage of the plant sample...
March 2018: Planta Medica
https://www.readbyqxmd.com/read/29240420/iodine-promoted-aromatization-of-p-menthane-type-phytocannabinoids
#6
Federica Pollastro, Diego Caprioglio, Patrizia Marotta, Aniello Schiano Moriello, Luciano De Petrocellis, Orazio Taglialatela-Scafati, Giovanni Appendino
Treatment with iodine cleanly converts various p-menthane-type phytocannabinoids and their carboxylated precursors into cannabinol (CBN, 1a). The reaction is superior to previously reported protocols in terms of simplicity and substrate range, which includes not only tricyclic tetrahydrocannabinols such as Δ9 -THC (2a) but also bicyclic phytocannabinoids such as cannabidiol (CBD, 3a). Lower homologues from the viridin series (2c and 3c, respectively) afforded cannabivarin (CBV), a non-narcotic compound that, when investigated against a series of ionotropic (thermo-TRPs) biological end-points of phytocannabinoids, retained the submicromolar TRPA1-activating and TRPM8-inhibiting properties of CBN, while also potently activating TRPV2...
March 23, 2018: Journal of Natural Products
https://www.readbyqxmd.com/read/29237190/determination-of-acid-and-neutral-cannabinoids-in-extracts-of-different-strains-of-cannabis-sativa-using-gc-fid
#7
Elsayed A Ibrahim, Waseem Gul, Shahbaz W Gul, Brandon J Stamper, Ghada M Hadad, Randa A Abdel Salam, Amany K Ibrahim, Safwat A Ahmed, Suman Chandra, Hemant Lata, Mohamed M Radwan, Mahmoud A ElSohly
Cannabis ( Cannabis sativa L.) is an annual herbaceous plant that belongs to the family Cannabaceae. Trans -Δ9 -tetrahydrocannabinol (Δ9 -THC) and cannabidiol (CBD) are the two major phytocannabinoids accounting for over 40% of the cannabis plant extracts, depending on the variety. At the University of Mississippi, different strains of C. sativa, with different concentration ratios of CBD and Δ9 -THC, have been tissue cultured via micropropagation and cultivated. A GC-FID method has been developed and validated for the qualitative and quantitative analysis of acid and neutral cannabinoids in C...
March 2018: Planta Medica
https://www.readbyqxmd.com/read/29189142/interpretation-of-cannabis-findings-in-the-hair-of-very-young-children-mission-impossible
#8
Pascal Kintz, Alice Ameline, Aude Eibel, Laurie Gheddar, Emilie Feisthauer, Annie Geraut, Laurent Berthelon, Audrey Farrugia, Jean-Sebastien Raul
BACKGROUND: Hair has been suggested since the middle of the 90's to be a suitable matrix to document repetitive exposure to cannabis. Because it is possible to detect Δ9-tetrahydrocannabinol (THC), cannabinol (CBN) and cannabidiol (CBD) in cannabis smoke, the identification of the metabolite, 11-nor-Δ9-tetrahydrocannabinol carboxylic acid (THC-COOH) has been considered to allow the discrimination of active use. OBJECTIVE: Although the identification of an active compound in a child's hair shows contamination of the local environment, it is a challenge to discriminate between hair incorporation after ingestion or inhalation and environmental external deposition from dust, smoke, or even contaminated surfaces by hand contact...
2017: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/29182999/analysis-of-cannabinoids-in-commercial-hemp-seed-oil-and-decarboxylation-kinetics-studies-of-cannabidiolic-acid-cbda
#9
Cinzia Citti, Barbara Pacchetti, Maria Angela Vandelli, Flavio Forni, Giuseppe Cannazza
Hemp seed oil from Cannabis sativa L. is a very rich natural source of important nutrients, not only polyunsaturated fatty acids and proteins, but also terpenes and cannabinoids, which contribute to the overall beneficial effects of the oil. Hence, it is important to have an analytical method for the determination of these components in commercial samples. At the same time, it is also important to assess the safety of the product in terms of amount of any psychoactive cannabinoid present therein. This work presents the development and validation of a highly sensitive, selective and rapid HPLC-UV method for the qualitative and quantitative determination of the main cannabinoids, namely cannabidiolic acid (CBDA), tetrahydrocannabinolic acid (THCA), cannabidiol (CBD), tetrahydrocannabinol (THC), cannabinol (CBN), cannabigerol (CBG) and cannabidivarin (CBDV), present in 13 commercial hemp seed oils...
February 5, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29126755/-cannabis-and-lung-what-we-know-and-everything-we-don-t-know-yet
#10
REVIEW
T Urban, J Hureaux
Cannabis use increased sharply from 2010 to 2014 in France. Cannabis is often consumed with tobacco, although the use of marijuana is developing. Tobacco and cannabis smoke have many common characteristics in terms of irritants, carcinogens and carbon monoxide. They also differentiate by their dependence mechanisms, with nicotine and its receptors for tobacco and tetra-hydro-cannabinol (THC) and its specific receptors for cannabis. Chronic inhalation (700,000 daily users in France) over a long period most likely increases the relative risk of bronchial cancer...
December 2017: Revue de Pneumologie Clinique
https://www.readbyqxmd.com/read/29125965/death-by-self-mutilation-after-oral-cannabis-consumption
#11
Clemence Delteil, Caroline Sastre, Marie-Dominique Piercecchi, Catherine Faget-Agius, Marc Deveaux, Pascal Kintz, Marc-Antoine Devooght, George Leonetti, Christophe Bartoli, Anne-Laure Pélissier-Alicot
Major self-mutilation (amputation, castration, self-inflicted eye injuries) is frequently associated with psychiatric disorders and/or substance abuse. A 35-year-old man presented with behavioral disturbances of sudden onset after oral cannabis consumption and major self-mutilation (attempted amputation of the right arm, self-enucleation of both eyes and impalement) which resulted in death. During the enquiry, four fragments of a substance resembling cannabis resin were seized at the victim's home. Autopsy confirmed that death was related to hemorrhage following the mutilations...
January 2018: Legal Medicine
https://www.readbyqxmd.com/read/29099795/microwave-assisted-extraction-of-cannabinoids-in-hemp-nut-using-response-surface-methodology-optimization-and-comparative-study
#12
Chih-Wei Chang, Ching-Chi Yen, Ming-Tsang Wu, Mei-Chich Hsu, Yu-Tse Wu
Hemp nut is commonly incorporated into several food preparations; however, most countries set regulations for hemp products according to their cannabinoid content. In this study, we have developed an efficient microwave-assisted extraction (MAE) method for cannabinoids (i.e., Δ9-tetrahydrocannabinol, cannabidiol, and cannabinol) in hemp nut. Optimization of the MAE procedure was conducted through single factor experiments and response surface methodology (RSM). A comparative study was also conducted to determine the differences in the extraction yields and morphology of hemp nut between MAE and reference extraction methods, namely heat reflux extraction (HRE), Soxhlet extraction (SE), supercritical fluid extraction (SFE), and ultrasound-assisted extraction (UAE)...
November 3, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29067762/study-on-the-interaction-between-cannabinol-and-dna-using-acridine-orange-as-a-fluorescence-probe
#13
Zhengshan Tian, Zechun Wang, Xinxin Han, Ning Wang, Ruiyong Wang
The interaction between cannabinol (CBN) and herring-sperm deoxyribonucleic acid was investigated by using acridine orange as a fluorescence probe in this work. UV-Vis spectroscopy, fluorescence spectroscopy, and DNA melting techniques were used. The fluorescence of DNA acridine orange was quenched by CBN. The results indicated that CBN can bind to DNA. The binding constant for the CBN and herring-sperm deoxyribonucleic acid was obtained at 3 temperatures, respectively. Results of molecular docking corroborated the experimental results obtained from spectroscopic investigations...
February 2018: Journal of Molecular Recognition: JMR
https://www.readbyqxmd.com/read/28977394/development-of-a-liquid-chromatography-tandem-mass-spectrometry-method-for-the-simultaneous-determination-of-four-cannabinoids-in-umbilical-cord-tissue
#14
Fang Wu, Triniti L Scroggin, Torri D Metz, Gwendolyn A McMillin
In utero exposure to marijuana may cause various short- and long-term health problems, such as stillbirth, low birth weight and decreased cognitive function. Detection of in utero marijuana exposure with a relatively new specimen type, umbilical cord tissue, can be used to plan treatment and guide social management. In this study, a liquid chromatography-tandem mass spectrometry (LC-MS-MS) assay was developed for the simultaneous identification of four cannabinoids in umbilical cord tissue, including ∆9-tetrahydrocannabinol (THC), 11-nor-9-carboxy-∆9--THC (THC-COOH), 11-hydroxy-∆9-THC (11-OH-THC) and cannabinol (CBN)...
January 1, 2018: Journal of Analytical Toxicology
https://www.readbyqxmd.com/read/28815938/optimization-of-recombinant-%C3%AE-glucuronidase-hydrolysis-and-quantification-of-eight-urinary-cannabinoids-and-metabolites-by-liquid-chromatography-tandem-mass-spectrometry
#15
Cristina Sempio, Karl B Scheidweiler, Allan J Barnes, Marilyn A Huestis
Prolonged urinary cannabinoid excretion in chronic frequent cannabis users confounds identification of recent cannabis intake that may be important in treatment, workplace, clinical, and forensic testing programs. In addition, differentiation of synthetic Δ9-tetrahydrocannabinol (THC) intake from cannabis plant products might be an important interpretive issue. THC, 11-hydroxy-THC (11-OH-THC) and 11-nor-9-carboxy-THC (THCCOOH) urine concentrations were evaluated during previous controlled cannabis administration studies following tandem alkaline/E...
March 2018: Drug Testing and Analysis
https://www.readbyqxmd.com/read/28736802/psychotropic-substances-in-house-dusts-a-preliminary-assessment
#16
Angelo Cecinato, Paola Romagnoli, Mattia Perilli, Catia Balducci
Psychotropic substances (PSs) are known to affect air and waters, while scarce attention has been paid to their occurrence in settled dusts although they can reach important concentrations there; moreover, no procedures have been developed for this specific purpose. In this study, a list of PSs (i.e., nicotine, cotinine, caffeine, cocaine, cannabinol, Δ(9)-tetrahydrocannabinol, cannabidiol, amphetamine, heroin, and methadone) were characterized in dusts from Rome and Fiumicino international airport, Italy, and from Ouargla city, Algeria...
September 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28640062/an-atmospheric-pressure-chemical-ionization-ms-ms-assay-using-online-extraction-for-the-analysis-of-11-cannabinoids-and-metabolites-in-human-plasma-and-urine
#17
Jelena Klawitter, Cristina Sempio, Sophie Mörlein, Erik De Bloois, Jacek Klepacki, Thomas Henthorn, Maureen A Leehey, Edward J Hoffenberg, Kelly Knupp, George S Wang, Christian Hopfer, Greg Kinney, Russell Bowler, Nicholas Foreman, Jeffrey Galinkin, Uwe Christians, Jost Klawitter
BACKGROUND: Although, especially in the United States, there has been a recent surge of legalized cannabis for either recreational or medicinal purposes, surprisingly little is known about clinical dose-response relationships, pharmacodynamic and toxicodynamic effects of cannabinoids such as Δ9-tetrahydrocannabinol (THC). Even less is known about other active cannabinoids. METHODS: To address this knowledge gap, an online extraction, high-performance liquid chromatography coupled with tandem mass spectrometry method for simultaneous quantification of 11 cannabinoids and metabolites including THC, 11-hydroxy-Δ9-tetrahydrocannabinol, 11-nor-Δ9-tetrahydrocannabinol-9-carboxylic acid, 11-nor-Δ9-tetrahydrocannabinol-9-carboxylic acid glucuronide (THC-C-gluc), cannabinol, cannabidiol, cannabigerol, cannabidivarin, Δ9-tetrahydrocannabivarin (THCV), and 11-nor-9-carboxy-Δ9-tetrahydrocannabivarin (THCV-COOH) was developed and validated in human urine and plasma...
October 2017: Therapeutic Drug Monitoring
https://www.readbyqxmd.com/read/28570781/the-effect-of-antioxidants-on-the-long-term-stability-of-thc-and-related-cannabinoids-in-sampled-whole-blood
#18
Lambert K Sørensen, Jørgen B Hasselstrøm
The stability of cannabinoids is complex and crucial for the assessment of impaired driving caused by cannabis. Therefore, the effect of antioxidants on the long-term stability of Δ9 -tetrahydrocannabinol (THC), cannabinol (CBN), cannabidiol (CBD), 11-hydroxy-Δ9 -tetrahydrocannabinol (THC-OH), and 11-nor-9-carboxy-Δ9 -tetrahydrocannabinol (THC-COOH) in whole blood samples preserved with fluoride citrate (FC) and fluoride oxalate (FX) mixtures was investigated at different temperatures. The measured concentrations of the cannabinoids in authentic whole blood preserved solely with FC or FX mixtures decreased significantly during prolonged storage at -20°C...
February 2018: Drug Testing and Analysis
https://www.readbyqxmd.com/read/28492950/psychoactive-constituents-of-cannabis-and-their-clinical-implications-a-systematic-review
#19
Cristina Casajuana Köguel, Hugo López-Pelayo, Mª Mercedes Balcells-Olivero, Joan Colom, Antoni Gual
Objective This systematic review aims to summarize current evidence on which naturally present cannabinoids contribute to cannabis psychoactivity, considering their reported concentrations and pharmacodynamics in humans. Design Following PRISMA guidelines, papers published before March 2016 in Medline, Scopus-Elsevier, Scopus, ISI-Web of Knowledge and COCHRANE, and fulfilling established a-priori selection criteria have been included. Results In 40 original papers, three naturally present cannabinoids (∆-9-Tetrahydrocannabinol, ∆-8-Tetrahydrocannabinol and Cannabinol) and one human metabolite (11-OH-THC) had clinical relevance...
April 15, 2018: Adicciones
https://www.readbyqxmd.com/read/28455844/open-probe-fast-gc-ms-combining-ambient-sampling-ultra-fast-separation-and-in-vacuum-ionization-for-real-time-analysis
#20
U Keshet, T Alon, A B Fialkov, A Amirav
An Open Probe inlet was combined with a low thermal mass ultra-fast gas chromatograph (GC), in-vacuum electron ionization ion source and a mass spectrometer (MS) of GC-MS for obtaining real-time analysis with separation. The Open Probe enables ambient sampling via sample vaporization in an oven that is open to room air, and the ultra-fast GC provides ~30-s separation, while if no separation is required, it can act as a transfer line with 2 to 3-s sample transfer time. Sample analysis is as simple as touching the sample, pushing the sample holder into the Open Probe oven and obtaining the results in 30 s...
July 2017: Journal of Mass Spectrometry: JMS
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