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Peripheral arterial disease AND Calcification

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https://www.readbyqxmd.com/read/28098103/relation-of-fibroblast-growth-factor-23-and-cardiovascular-calcification-in-end-stage-kidney-disease-patients-on-regular-hemodialysis
#1
Tarek Zakaria El Baz, Osama Ahmed Khamis, Osama Ashry Ahmed Gheith, Salama Saad Abd Ellateif, Abdallah Mahmoud Abdallah, Hussein Chahine Abd El Aal
More than half of deaths in end-stage kidney disease (ESKD) patients are due to cardiovascular disease. Elevated fibroblast growth factor 23 (FGF-23) was found to be associated with mortality in hemodialysis (HD) patients and correlates with peripheral calcification. Aortic calcification is associated with coronary artery calcification. Both aortic and peripheral vascular calcifications were associated with mortality in chronic kidney disease. We aimed to investigate the relation between intact FGF-23 and cardiovascular calcification in patients with ESKD who were maintained on regular HD...
January 2017: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/28089997/the-impact-of-age-and-sex-on-in-hospital-outcomes-of-chronic-total-occlusion-percutaneous-coronary-intervention
#2
Aris Karatasakis, Rahel Iwnetu, Barbara A Danek, Dimitri Karmpaliotis, Khaldoon Alaswad, Farouc A Jaffer, Robert W Yeh, David E Kandzari, Nicholas J Lembo, Mitul Patel, Ehtisham Mahmud, William L Lombardi, R Michael Wyman, J Aaron Grantham, Anthony H Doing, Catalin Toma, James W Choi, Barry F Uretsky, Jeffrey W Moses, Ajay J Kirtane, Ziad A Ali, Manish Parikh, Judit Karacsonyi, Bavana V Rangan, Craig A Thompson, Subhash Banerjee, Emmanouil S Brilakis
OBJECTIVES: We sought to determine the effect of age and sex on procedural outcomes and efficiency of chronic total occlusion (CTO) percutaneous coronary intervention (PCI). METHODS: We examined the clinical and angiographic characteristics and outcomes of 1675 CTO-PCIs performed in 1644 patients between 2012 and 2016 at 15 United States centers. RESULTS: Mean age was 65.3 ± 10 years and 1408 (86%) were men. Overall technical and procedural success rates were 88% and 87%, respectively...
January 15, 2017: Journal of Invasive Cardiology
https://www.readbyqxmd.com/read/28067862/impact-of-indoxyl-sulfate-on-progenitor-cell-related-neovascularization-of-peripheral-arterial-disease-and-post-angioplasty-thrombosis-of-dialysis-vascular-access
#3
REVIEW
Chih-Cheng Wu, Szu-Chun Hung, Ko-Lin Kuo, Der-Cherng Tarng
Patients with chronic kidney disease (CKD) have an increased risk of vascular disease, which is associated with considerable health care costs. Vascular disease in CKD differs clinically and pathobiologically from that in patients with normal renal function. Besides the traditional risk factors, retention of uremic toxins contributes to the pathogenesis of vascular disease in patients with CKD. Indoxyl sulfate is a protein-bound uremic toxin and is inefficiently removed by conventional dialysis. Accumulating evidence suggests that indoxyl sulfate is a vascular toxin involved in atherosclerosis, arteriosclerosis, vascular calcification and vascular repair...
January 7, 2017: Toxins
https://www.readbyqxmd.com/read/28045673/orbital-atherectomy-in-the-renal-artery-a-new-frontier-for-an-emerging-technology
#4
Javier A Valle, Ehrin J Armstrong, Stephen W Waldo
Orbital atherectomy has been developed as a method to modify calcified plaque in the peripheral vasculature, with extensive experience and data supporting its use in infrainguinal peripheral arterial disease. However, calcific atherosclerotic disease occurs in other vascular beds and may benefit from the application of this technology. In this case report, we describe the first reported use of orbital atherectomy in a renal artery. A 55-year-old male with severe drug-refractory hypertension was found to have renal artery stenosis, with severe calcification of the right renal artery...
January 2017: Journal of Invasive Cardiology
https://www.readbyqxmd.com/read/28044253/transvenous-inoue-balloon-aortic-valvuloplasty-with-intra-aortic-balloon-pump-in-treating-cardiogenic-shock-due-to-critical-calcific-aortic-stenosis
#5
Yoshihito Sakata
A 90-year-old female with severe peripheral vascular disease developed cardiogenic shock (CS) due to critical aortic stenosis (AS). The balloon aortic valvuloplasty was emergently performed via transvenous and transseptal antegrade approach (ante-BAV), which saved arterial accesses for intra-aortic balloon pump (IABP) and enabled us to use the Inoue balloon. The IABP augmented systemic perfusions and controlled left heart filling pressures. Multiple times of inflations with stepwisely increased balloon diameters were performed under IABP support (ante-Inoue-BAV + IABP), resulting in remarkable improvements both in clinical and hemodynamic conditions...
January 2, 2017: Cardiovascular Intervention and Therapeutics
https://www.readbyqxmd.com/read/28040289/two-year-outcomes-after-percutaneous-coronary-intervention-of-calcified-lesions-with-drug-eluting-stents
#6
Philippe Généreux, Björn Redfors, Bernhard Witzenbichler, Marie-Pier Arsenault, Giora Weisz, Thomas D Stuckey, Michael J Rinaldi, Franz-Josef Neumann, D Christopher Metzger, Timothy D Henry, David A Cox, Peter L Duffy, Ernest L Mazzaferri, Dominic P Francese, Guillaume Marquis-Gravel, Gary S Mintz, Ajay J Kirtane, Akiko Maehara, Roxana Mehran, Gregg W Stone
BACKGROUND: Percutaneous coronary intervention (PCI) of lesions with coronary arterial calcification (CAC) is common and has been historically associated with an increased risk of adverse events. Whether the association between target lesion calcification (CAC) and outcomes differ across drug-eluting stent generation or between patients with high vs. low residual platelet reactivity (PR) remains unknown. We assessed the association of CAC with adverse ischemic and bleeding events among patients undergoing contemporary PCI with drug-eluting stents (DES)...
December 26, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27993830/secondhand-smoke-exposure-and-subclinical-cardiovascular-disease-the-multi-ethnic-study-of-atherosclerosis
#7
Miranda R Jones, Hoda S Magid, Mahmoud Al-Rifai, John W McEvoy, Joel D Kaufman, Karen D Hinckley Stukovsky, Moyses Szklo, Joseph Polak, Gregory L Burke, Wendy S Post, Michael J Blaha, Ana Navas-Acien
BACKGROUND: Few studies have evaluated the association between secondhand smoke (SHS) and subclinical cardiovascular disease among ethnically diverse populations. This study assesses the impact of SHS on inflammation and atherosclerosis (carotid intima-media thickness, coronary artery calcification, and peripheral arterial disease). METHODS AND RESULTS: We examined 5032 nonsmoking adults aged 45 to 84 years without prior cardiovascular disease participating in the Multi-Ethnic Study of Atherosclerosis (MESA) from 2000 to 2002...
December 19, 2016: Journal of the American Heart Association
https://www.readbyqxmd.com/read/27976549/dynamic-sheaths-in-the-nick-of-time-or-past-their-prime
#8
EDITORIAL
Zvonimir Krajcer, Dhaval Parekh
Risk factors for vascular complications include a sheath to femoral artery ratio (SFAR) > 1.05, use of sheaths >19 Fr, peripheral artery disease, female gender, and a learning curve. High rates of technical and procedural success were achieved with low rates of major vascular and bleeding complications. However, SFAR > 1.05, gender, diabetes, renal insufficiency, calcification, tortuosity, or aneurysm were not independent risk factors in this study. Despite an SFAR > 1.05 in 23 patients, increased rates of vascular complications were not seen using the SoloPath sheath...
December 2016: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/27919637/critical-hand-ischemia-treatment-via-orbital-atherectomy-a-single-center-observational-retrospective-analysis
#9
Abdul Bahro, Zsuzsanna Igyarto, Brad Martinsen
BACKGROUND/PURPOSE: Critical hand ischemia (CHI) can be devastating and may result in amputation. Distal vessel calcification has been shown to be a major factor in causing CHI. Atherectomy in the upper extremities is not typically considered due to the small anatomy; however, the Diamondback 360° Peripheral Orbital Atherectomy System (OAS) (Cardiovascular Systems, Inc.) can access treatment areas with a reference vessel diameter of 1.5mm. METHODS/MATERIALS: A retrospective, observational, single center (Merit Health Center, Jackson, MS) analysis of 11 CHI patients with calcific disease of the radial artery treated with orbital atherectomy (OAS) was completed...
October 29, 2016: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://www.readbyqxmd.com/read/27899247/association-of-plasma-fetuin-a-levels-with-peripheral-arterial-disease-and-lower-extremity-arterial-calcification-in-subjects-with-type-2-diabetes-mellitus
#10
Ioanna Eleftheriadou, Pinelopi Grigoropoulou, Alexander Kokkinos, Iordanis Mourouzis, Despoina Perrea, Nicholas Katsilambros, Petros P Sfikakis, Nikolaos Tentolouris
AIMS: Fetuin-A is a hepatic glycoprotein that is involved in insulin resistance and atherosclerosis. Herein we examined the association of plasma fetuin-A levels with peripheral arterial disease (PAD) in patients with type 2 diabetes mellitus (T2DM). MATERIAL AND METHODS: A total of 71 patients with T2DM and 57 non-diabetic individuals were recruited. Diagnosis of PAD was based on the absence of triphasic waveform at pedal arteries, while ankle-brachial index (ABI) was calculated...
November 12, 2016: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/27898199/microsurgical-reconstruction-in-patients-greater-than-80-years-old
#11
Paul I Heidekrueger, Albrecht Heine-Geldern, Milomir Ninkovic, Frank Herter, Daniel Schmauss, Thiha Aung, P Niclas Broer
BACKGROUND: Demographic change implies that the human population is getting older and the elderly are living longer. Consequently, achieving good functional and aesthetic outcomes in microvascular procedures, especially in very old patients with higher incidence of atherosclerosis and vessel calcifications, constitutes a microsurgical challenge. This study evaluates the feasibility of microsurgical procedures in a very old patient cohort. PATIENTS AND METHODS: Between 2009 and 2015, 754 patients underwent 838 free flap reconstructions...
November 29, 2016: Microsurgery
https://www.readbyqxmd.com/read/27890524/the-dancavas-pilot-study-of-multifaceted-screening-for-subclinical-cardiovascular-disease-in-men-and-women-aged-65-74%C3%A2-years
#12
T V Kvist, J S Lindholt, L M Rasmussen, R Søgaard, J Lambrechtsen, F H Steffensen, L Frost, M H Olsen, H Mickley, J Hallas, G Urbonaviciene, M Busk, K Egstrup, A C P Diederichsen
OBJECTIVE/BACKGROUND: This pilot study of a large population based randomised screening trial investigated feasibility, acceptability, and relevance (prevalence of clinical and subclinical cardiovascular disease [CVD] and proportion receiving insufficient prevention) of a multifaceted screening for CVD. METHODS: In total, 2060 randomly selected Danish men and women aged 65-74 years were offered (i) low dose non-contrast computed tomography to detect coronary artery calcification (CAC) and aortic/iliac aneurysms; (ii) detection of atrial fibrillation (AF); (iii) brachial and ankle blood pressure measurements; and (iv) blood levels of cholesterol and hemoglobin A1c...
January 2017: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/27865565/-ankle-brachial-index-screening-for-peripheral-artery-disease-in-high-cardiovascular-risk-patients-prospective-observational-study-of-370-asymptomatic-patients-at-high-cardiovascular-risk
#13
C Rada, S Oummou, F Merzouk, B Amarir, G Boussabnia, H Bougrini, D Benzaroual, S Elkarimi, M Elhattaoui
INTRODUCTION: Peripheral arterial disease is a marker of systemic atherosclerosis; it is associated with a high risk of cardiovascular disease. The aim of our study was to assess the prevalence of peripheral arterial disease by measuring the ankle-brachial pressure index in patients at high cardiovascular risk and to study the risk factors associated with this disease. METHODOLOGY: This was a descriptive and analytic cross-sectional study which focused on 370 patients seen at the medical consultation for atherosclerosis prevention...
December 2016: Journal des Maladies Vasculaires
https://www.readbyqxmd.com/read/27836295/circulating-osteogenic-endothelial-progenitor-cell-counts-new-biomarker-for-the-severity-of-coronary-artery-disease
#14
Shi-Wei Yang, Rebecca R Hennessy, Sundeep Khosla, Ryan Lennon, Darrell Loeffler, Tao Sun, Zhi Liu, Kyoung-Ha Park, Fei-Long Wang, Lilach O Lerman, Amir Lerman
BACKGROUND: There is increasing evidence implying that the early and functionally highly active circulating endothelial progenitor cell (CEPC) phenotype (CD34-/CD133+/KDR+) with osteogenic potential (OCN+) might link between vascular atherosclerotic calcification and mechanisms of bone metabolism. We sought to evaluate the early OCN+ CEPC counts as an independent biomarker for the severity of coronary artery disease (CAD). METHODS: Peripheral blood samples were drawn from 593 patients undergoing clinically indicated coronary angiography...
January 15, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/27821353/time-dependent-differences-in-femoral-artery-plaque-characteristics-of-peripheral-arterial-disease-patients
#15
Saskia Haitjema, Steven T W van Haelst, Jean-Paul P M de Vries, Frans L Moll, Hester M den Ruijter, Gert J de Borst, Gerard Pasterkamp
BACKGROUND AND AIMS: Peripheral arterial disease (PAD) is a common manifestation of atherosclerosis with an increasing incidence worldwide. The disease is still associated with high morbidity and mortality risks. Previous research in carotid arteries indicates that atherosclerotic plaque characteristics have stabilized over time in patients considered for surgery. It is currently unknown whether this time-dependent stabilization occurs in ilio-femoral arteries as well. Our objective was to analyze whether local ilio-femoral atherosclerotic plaque characteristics have changed over time...
December 2016: Atherosclerosis
https://www.readbyqxmd.com/read/27789446/residential-proximity-to-traffic-related-pollution-and-atherosclerosis-in-4-vascular-beds-among-african-american-adults-results-from-the-jackson-heart-study
#16
Yi Wang, Gregory A Wellenius, DeMarc A Hickson, Annie Gjelsvik, Charles B Eaton, Sharon B Wyatt
To our knowledge, no study has investigated the association of long-term exposure to traffic pollution with markers of atherosclerosis in 4 vascular beds simultaneously in an all-African-American cohort. Among participants in the Jackson Heart Study (Jackson, Mississippi; baseline mean age = 55.5 (standard deviation, 12.7) years), we used linear regression to estimate percent differences in carotid intima-media thickness (CIMT) at baseline (2004) and used modified Poisson regression (robust error variance) to estimate prevalence ratios for peripheral artery disease (PAD), coronary artery calcification (CAC), and abdominal aortic calcification (AAC) at the first follow-up visit (2005-2008) for persons living less than 150 m (versus more than 300 m) from major roadways, adjusting for confounders...
October 27, 2016: American Journal of Epidemiology
https://www.readbyqxmd.com/read/27765310/local-ultrasound-to-enhance-paclitaxel-delivery-after-femoral-popliteal-treatment%C3%A2-in-critical-limb-ischemia-the-pacus-trial
#17
Roberto Gandini, Costantino Del Giudice
OBJECTIVES: The aim of this study was to evaluate the safety and efficacy of percutaneous catheter-delivered ultrasound energy to improve local paclitaxel delivery effects in patients with critical limb ischemia (CLI) treated for femoral-popliteal arterial disease. BACKGROUND: Treatment of patients with CLI continues to be the greatest challenge in peripheral artery disease; in particular, treatment of femoral-popliteal chronic total occlusion is characterized by poor primary patency...
October 24, 2016: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/27753721/multidetector-64-computed-tomography-angiography-of-the-lower-limb-in-symptomatic-peripheral-arterial-disease-assessment-of-image-quality-and-accuracy-in-a-tertiary-care-setting
#18
Jeremy C Lim, Dinesh Ranatunga, Andrew Owen, Tim Spelman, Michael Galea, Jason Chuen, Ruth P Lim
OBJECTIVE: The aim of this study was to evaluate image quality and accuracy of 64+ detector multidetector computed tomography angiography (MDCTA) for hemodynamically significant (≥50%) stenosis in patients with symptomatic peripheral arterial disease (PAD) using digital subtraction angiography as the reference standard. METHODS: This is a retrospective study of 29 patients with PAD (19 men, 10 women) who underwent lower limb MDCTA (64- or 80-detector) and digital subtraction angiography...
October 7, 2016: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/27703657/lower-extremity-arterial-calcification-as-a-predictor-of-coronary-atherosclerosis-in-patients-with-peripheral-arterial-disease
#19
Hwa Seon Shin, Mi Jung Park, Kyung Nyeo Jeon, Jae Min Cho, Kyung Soo Bae, Dae Seob Choi, Jae Boem Na, Ho Cheol Choi, Hye Young Choi, Ji Eun Kim, Soo Bueum Cho, Sung Eun Park
BACKGROUND: Until now, there has been no study on the relationship between the calcification of the lower extremity arteries and significant coronary arterial disease (CAD). OBJECTIVES: To evaluate whether lower extremity calcium scores (LECS) are associated with CAD and whether this can predict multivessel-CAD in patients with peripheral arterial disease (PAD). PATIENTS AND METHODS: We retrospectively enrolled 103 PAD patients without cardiac symptoms or known CAD...
April 2016: Iranian Journal of Radiology: a Quarterly Journal Published By the Iranian Radiological Society
https://www.readbyqxmd.com/read/27703086/emerging-risk-factors-for-recurrent-vascular-events-in-patients-with-embolic-stroke-of-undetermined-source
#20
Yuji Ueno, Kazuo Yamashiro, Ryota Tanaka, Takuma Kuroki, Kenichiro Hira, Naohide Kurita, Takao Urabe, Nobutaka Hattori
BACKGROUND AND PURPOSE: Underlying embolic causes diagnosed by transesophageal echocardiography could be implicated in mechanisms of embolic stroke of undetermined source. We aimed to explore factors, including underlying embolic causes, related to recurrent vascular events in embolic stroke of undetermined source. METHODS: Patients who fulfilled the diagnostic criteria for embolic stroke of undetermined source and whose potential embolic sources were examined by transesophageal echocardiography were included...
November 2016: Stroke; a Journal of Cerebral Circulation
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