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Peripheral arterial disease AND Calcification

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https://www.readbyqxmd.com/read/29725581/a-high-ankle-brachial-index-is-associated-with-obesity-and-low-serum-25-hydroxyvitamin-d-in-patients-with-diabetes
#1
Barbara Depczynski, Tamara Young, Christopher White
Peripheral artery disease (PAD), when present with diabetes, is associated with significant morbidity and mortality. The spectrum of PAD in diabetes includes atherosclerosis with stenotic disease; and diffuse medial calcification with non-compliant arteries, as reflected by high ankle brachial index. The clinical characteristics of a high ABI are less well characterized than that of low ABI. The aim of this study was to determine the unique clinical phenotype of patients with diabetes who have high ankle brachial index (ABI) reading...
March 2018: Journal of Clinical & Translational Endocrinology
https://www.readbyqxmd.com/read/29721920/acquired-peripheral-pulmonary-artery-aneurysms-morphological-spectrum-of-disease-and-multidetector-computed-tomography-angiography-findings-cases-series-and-literature-review
#2
REVIEW
Tullio Valente, Ahmad Abu-Omar, Giacomo Sica, Alfredo Clemente, Massimo Muto, Giorgio Bocchini, Salvatore Cappabianca, Gaetano Rea
BACKGROUND: Acquired peripheral or intraparenchymal pulmonary artery aneurysms (PPAA) are rare entities but are important to recognize because of the associated morbidity. Hemoptysis is their principal complication and is a potentially fatal condition. PURPOSE: To illustrate the causes, multidetector CT angiography (MDCTA) findings and differential diagnosis of acquired PPAA. MATERIALS AND METHODS: The institutional review boards approved this study...
May 2, 2018: La Radiologia Medica
https://www.readbyqxmd.com/read/29701404/digital-subtraction-angiography-or-computed-tomography-angiography-in-the-preoperative-evaluation-of-lower-limb-peripheral-artery-disease-a-comparative-analysis
#3
Marina Dias-Neto, Catarina Marques, Sérgio Sampaio
INTRODUCTION: For several years, digital subtraction angiography (DSA) was considered the gold standard method for the evaluation of PAD patients. This is an invasive technique and allows a good evaluation of collaterals and the vessel lumen, even in cases with associated calcification. Nevertheless, recent technical development of computed tomography angiography (CTA) has improved its specificity and sensibility, besides the fact that CTA is a fast and non-invasive procedure. OBJECTIVE: To characterize a cohort of lower limb PAD patients and clarify if there are differences among the patients preoperatively evaluated by DSA or CTA...
July 2017: Revista Portuguesa de Cirurgia Cardio-torácica e Vascular
https://www.readbyqxmd.com/read/29701379/which-aneurysm-characteristics-predict-evar-nonsuccess
#4
Pedro Pinto Sousa, Pedro Brandão, Alexandra Canedo
INTRODUCTION: Hostile anatomic characteristics in patients undergoing endovascular abdominal aortic aneurysm repair (EVAR) may lead to technical nonsuccess of the procedure, late complications, reintervention or death. The authors analyzed anatomical abdominal aortic aneurysm specific considerations so as technical endoprosthesis implantation and correlate them with endoleak development and postoperative survival. METHODS: Authors retrospectively reviewed all consecutive, elective, EVAR's that occurred between 2010 and 2016, with available data, at one institution for abdominal, infra renal, aortic aneurysms...
July 2017: Revista Portuguesa de Cirurgia Cardio-torácica e Vascular
https://www.readbyqxmd.com/read/29658870/descending-thoracic-aortic-aneurysm-rupture-treated-with-thoracic-endovascular-aortic-repair-in-a-patient-with-peripheral-artery-disease
#5
Ovidiu Stiru, Roxana Carmen Geana, Platon Pavel, Marian Croitoru, Cristian Boros, Ion Iovu, Vlad Anton Iliescu
Descending thoracic aortic aneurysm rupture is a life-threatening disease associated with high rates of morbidity and mortality. Treatment in these cases is a surgical emergency. Less invasive therapies for the treatment of this pathology have been developed over time. For descending thoracic aneurysm rupture, endovascular stent grafting is less invasive, life-saving, and a unique alternative to open repair. However, this approach is subject to anatomical and logistic limitations. The purpose of the present study is to report a case of an emergency endovascular repair for a ruptured thoracic aortic aneurysm in a patient with peripheral arterial disease, and to discuss some important issues related to this approach...
March 20, 2018: Heart Surgery Forum
https://www.readbyqxmd.com/read/29652038/analysis-of-novel-cardiovascular-biomarkers-in-patients-with-peripheral-artery-disease-pad
#6
Peter Jirak, Moritz Mirna, Bernhard Wernly, Vera Paar, Marcus Thieme, Stefan Betge, Marcus Franz, Uta Hoppe, Alexander Lauten, Jürgen Kammler, Paul C Schulze, Michael Lichtenauer, Daniel Kretzschmar
BACKGROUND: Peripheral artery disease (PAD) is a common form of manifestation of atherosclerosis. PAD has a considerable impact on morbidity, hospitalisation rates and health- care costs. Biomarkers have been introduced in many cardiovascular disease entities over the last years. However, an analysis on the correlation of biomarker levels and PAD is still lacking. METHODS: A total of 106 patients were enrolled in this current study, 51 that were diagnosed with PAD and 55 with excluded coronary and peripheral artery disease as controls...
April 12, 2018: Minerva Medica
https://www.readbyqxmd.com/read/29627067/novel-developments-in-non-invasive-imaging-of-peripheral-arterial-disease-with-ct-experience-with-state-of-the-art-ultra-high-resolution-ct-and-subtraction-imaging
#7
REVIEW
R Tanaka, K Yoshioka, H Takagi, J D Schuijf, K Arakita
Despite advances, challenges remain for less invasive imaging of peripheral arterial occlusive disease (PAOD) using computed tomography (CT) angiography. The application of dual-energy imaging to PAOD has been reported to improve the diagnostic accuracy of this application; however, severe arteriosclerosis with heavy arterial wall calcification still hampers definitive lesion characterisation, especially in distal and smaller arteries. Recently an ultra-high resolution scanner has been introduced. In combination with advances in post-processing, such as subtraction techniques, these developments may overcome some of the current challenges and allow far more detailed characterisation of PAOD non-invasively...
April 4, 2018: Clinical Radiology
https://www.readbyqxmd.com/read/29548814/renin-and-aldosterone-are-not-associated-with-vulnerable-plaque-characteristics-in-patients-with-carotid-artery-disease
#8
Marieke A Hillaert, Hester M den Ruijter, Imo E Hoefer, Eef G Lentjes, Gert J de Borst, Jean-Paul P M de Vries, Pieter A Doevendans, Gerard Pasterkamp, Leo Timmers
BACKGROUND: The renin-angiotensin-aldosterone system is increasingly being recognized to play an important role in the development and clinical course of cardiovascular diseases. Renin-angiotensin-aldosterone system activation is associated with clinical outcome in various populations of cardiovascular patients, such as patients with coronary artery, peripheral artery, and cerebrovascular disease. In this study, we investigated the associations between plasma renin and aldosterone concentrations and atherosclerotic plaque characteristics and secondary vascular events in patients undergoing carotid endarterectomy...
March 13, 2018: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/29531756/microrna-8059-as-a-marker-for-the-presence-and-extent-of-coronary-artery-calcification
#9
Philippa Howlett, Jane K Cleal, Huihai Wu, Nikunj Shah, Alex Horton, Nick Curzen, Michael Mahmoudi
Objective: MicroRNAs (miRNAs) may serve as potential biomarkers in a variety of pathologies. The aim of this study was to determine whether miRNAs could serve as blood-based markers of isolated coronary artery calcification (CAC) defined as CAC in the absence of an underlying metabolic abnormality. Methods: 24 age-matched and sex-matched patients who had been referred for elective CT coronary calcium score and angiography as part of investigation for cardiac chest pain were recruited...
2018: Open Heart
https://www.readbyqxmd.com/read/29522810/vascular-complications-in-the-sapien-3-era-continued-role-of-transapical-approach-to-transcatheter-aortic-valve-replacement
#10
William Toppen, William Suh, Olcay Aksoy, Peyman Benharash, Cayley Bowles, Richard J Shemin, Murray Kwon
With the introduction of the latest generation Sapien 3 (S3) transcatheter aortic valve, there has been a reduction in the usage of transapical (TA) approach for transcatheter aortic valve replacements in many centers. However, despite the smaller sheath size and the more streamlined delivery system, vascular complications continue to occur, especially in patients with peripheral vascular disease. Thus, our institution has maintained a stringent TA protocol aiming to prevent these complications. We hypothesize that this protocol has helped to reduce vascular complications and improve outcomes at our institution even in the S3 era...
March 6, 2018: Seminars in Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29519353/etidronate-for-prevention-of-ectopic-mineralization-in-patients-with-pseudoxanthoma-elasticum
#11
Guido Kranenburg, Pim A de Jong, Jonas W Bartstra, Suzanne J Lagerweij, Marnix G Lam, Jeannette Ossewaarde-van Norel, Sara Risseeuw, Redmer van Leeuwen, Saskia M Imhof, Harald J Verhaar, Job J de Vries, Riemer H J A Slart, Gert Luurtsema, Annemarie M den Harder, Frank L J Visseren, Willem P Mali, Wilko Spiering
BACKGROUND: In pseudoxanthoma elasticum (PXE), low pyrophosphate levels may cause ectopic mineralization, leading to skin changes, visual impairment, and peripheral arterial disease. OBJECTIVES: The authors hypothesized that etidronate, a pyrophosphate analog, might reduce ectopic mineralization in PXE. METHODS: In the Treatment of Ectopic Mineralization in Pseudoxanthoma Elasticum trial, adults with PXE and leg arterial calcifications (n = 74) were randomly assigned to etidronate or placebo (cyclical 20 mg/kg for 2 weeks every 12 weeks)...
March 13, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29478047/arterial-stiffness-in-chronic-kidney-disease-and-end-stage-renal-disease
#12
Gerard M London
Accelerated ageing is observed in patients with chronic kidney disease (CKD)/end-stage renal disease. Premature vascular aging and arterial stiffening are the most characteristic features of this "progeria" that is already observed in those with the early stages of CKD. Aortic stiffening is associated with high characteristic impedance, left ventricular hypertrophy, decreased coronary perfusion, and is a strong prognostic marker of mortality and cardiovascular morbidity. With aging, the arterial stiffening is more pronounced in the aorta and central arteries than in peripheral conduit arteries...
2018: Blood Purification
https://www.readbyqxmd.com/read/29466936/utilization-and-in-hospital-outcomes-associated-with-atherectomy-in-the-treatment-of-peripheral-vascular-disease-an-observational-analysis-from-the-national-inpatient-sample
#13
Rajkumar Doshi, Evan Shlofmitz, Perwaiz Meraj
Objective Percutaneous revascularization for patients with peripheral arterial disease has become a treatment of choice for many symptomatic patients. The presence of severe arterial calcification presents many challenges for successful revascularization. Atherectomy is an adjunctive treatment option for patients with severe calcification undergoing percutaneous intervention. We sought to analyze the impact of atherectomy on in-hospital outcomes, length of stay, and cost in the percutaneous treatment of peripheral arterial disease...
January 1, 2018: Vascular
https://www.readbyqxmd.com/read/29452721/use-of-the-gore-tigris-vascular-stent-in-advanced-femoropopliteal-peripheral-arterial-disease
#14
Pierleone Lucatelli, Marco Cini, Giulio Tommasino, Antonio Benvenuti, Giulia Guaccio, Stefano Bascetta, Eugenio Neri, Carmelo Ricci
PURPOSE: To prospectively evaluate the safety and efficacy of using the Tigris vascular stent (Gore, Flagstaff, Arizona) alone or in combination with the Viabahn stent (Gore) for revascularizing femoropopliteal Trans-Atlantic Intersociety Consensus (TASC) type B-D lesions with varying degrees of calcification. MATERIALS AND METHODS: Patients with Rutherford stage ≥ 3 and TASC type ≥ B were included in the study. From January 2015 to April 2017, 31 segments in 31 patients (21 men, ovarall mean age 73...
May 2018: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/29432063/approach-to-pulmonary-hypertension-from-ct-to-clinical-diagnosis
#15
Felipe Aluja Jaramillo, Fernando R Gutierrez, Federico G Díaz Telli, Sebastian Yevenes Aravena, Cylen Javidan-Nejad, Sanjeev Bhalla
Pulmonary hypertension (PH) is a condition characterized by increased pressure in the pulmonary circulation. It may be idiopathic or arise in the setting of other clinical conditions. Patients with PH tend to present with nonspecific cardiovascular or respiratory symptoms. The clinical classification of PH was recently revised at the World Health Organization symposium in Nice, France, in 2013. That consensus statement provided an updated classification based on the shared hemodynamic characteristics and management of the different categories of PH...
March 2018: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/29386304/abdominal-aortic-calcifications-predict-survival-in-peritoneal-dialysis-patients
#16
Satu M Mäkelä, Markku Asola, Henrik Hadimeri, James G Heaf, Maija Heiro, Leena Kauppila, Susanne Ljungman, Mai Ots-Rosenberg, Johan V Povlsen, Björn Rogland, Petra Roessel, Jana Uhlinova, Maarit Vainiotalo, Maria K Svensson, Heini Huhtala, Heikki Saha
BACKGROUND: Peripheral arterial disease and vascular calcifications contribute significantly to the outcome of dialysis patients. The aim of this study was to evaluate the prognostic role of severity of abdominal aortic calcifications and peripheral arterial disease on outcome of peritoneal dialysis (PD) patients using methods easily available in everyday clinical practice. METHODS: We enrolled 249 PD patients (mean age 61 years, 67% male) in this prospective, observational, multicenter study from 2009 to 2013...
January 31, 2018: Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis
https://www.readbyqxmd.com/read/29371245/prevalence-of-calcification-in-human-femoropopliteal-arteries-and-its-association-with-demographics-risk-factors-and-arterial-stiffness
#17
Alexey Kamenskiy, William Poulson, Sylvie Sim, Austin Reilly, Jiangtao Luo, Jason MacTaggart
OBJECTIVE: Arterial calcification and stiffening increase the risk of reconstruction failure, amputation, and mortality in patients with peripheral arterial disease, but underlying mechanisms and prevalence are unclear. APPROACH AND RESULTS: Fresh human femoropopliteal arteries were obtained from n=431 tissue donors aged 13 to 82 years (mean age, 53±16 years) recording the in situ longitudinal prestretch. Arterial diameter, wall thickness, and opening angles were measured optically, and stiffness was assessed using planar biaxial extension and constitutive modeling...
April 2018: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/29296066/multimodality-imaging-assessment-of-a-caseous-calcification-of-the-mitral-valve-annulus
#18
Imen Hamdi, Chadia Chourabi, Younes Arous, Mehdi Ghommidh, Khalil Houissa, Abdeddayem Haggui, Nadhem Hajlaoui, Dhaker Lahidheb, Nejmeddine Ben Abdallah, Wafa Fehri, Habib Haouala
Caseous calcification of the mitral annulus (CCMA) is a rare echocardiographic finding. It is commonly misdiagnosed as an abscess, tumor or infective vegetation on the mitral valve. Since it is a benign process, differentiating it from malignant intra-cardiac mass is primordial to avoid unnecessary surgery. Various imaging modalities can be complimentary for definitive diagnosis. We present a case of CCMA in a 71-year-old female patient. Her medical history revealed hypertension, diabetes mellitus, hyperlipidaemia and coronary artery disease...
January 2018: Journal of the Saudi Heart Association
https://www.readbyqxmd.com/read/29250991/subjecting-the-ankle-brachial-index-to-timely-scrutiny-is-it-time-to-say-goodbye-to-the-abi
#19
Robert Trevethan
Although the ankle-brachial index (ABI) has been used as an indicator of peripheral artery disease and vascular supply to the foot for over 50 years, it is now associated with reservations and qualifying empirical evidence to the extent that the provocative step of abandoning it totally might be advisable. In this article, the results of three publications concerning the ABI are initially described in some depth and the results from eight additional publications are then summarized more briefly. Cumulatively, the research indicates that ABIs that seem to be normal, as well as those in the subnormal range, are often inflated by medial arterial calcification and can therefore produce a high proportion of false-negative screening test results for arterial disease as well as a misleadingly high impression of vascular sufficiency to the lower extremity...
February 2018: Scandinavian Journal of Clinical and Laboratory Investigation
https://www.readbyqxmd.com/read/29217435/determination-of-risk-factors-and-establishment-of-a-prediction-model-for-immediate-technical-failure-during-endovascular-treatment-of-femoropopliteal-occlusive-disease
#20
Yi-Hui Qiu, Guan-Feng Yu, Huan-Hao Zhou, Hu-Wei Xia, Li Chen, Hao-Tian Chen, Yuan-Yong Jiao, Zi-Heng Wu, Xiang-Tao Zheng
BACKGROUND: For long femoropopliteal occlusive lesions, the immediate technical failure (ITF) of endovascular treatment (EVT) is relatively high. Therefore, this study aims to reveal risk factors and establish a prediction model of ITF of EVT in femoropopliteal occlusive disease (FPOD) patients based on preoperative clinical date that may be helpful to the clinical procedures. METHODS: A retrospective analysis of 1,563 FPOD patients who underwent above-the-knee EVT was undertaken...
December 5, 2017: Annals of Vascular Surgery
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