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https://www.readbyqxmd.com/read/28335548/study-of-different-variants-of-mo-enzyme-crarc-and-the-interaction-with-its-partners-crcytb5-r-and-crcytb5-1
#1
Alejandro Chamizo-Ampudia, Aurora Galvan, Emilio Fernandez, Angel Llamas
The mARC (mitochondrial Amidoxime Reducing Component) proteins are recently discovered molybdenum (Mo) Cofactor containing enzymes. They are involved in the reduction of several N-hydroxylated compounds (NHC) and nitrite. Some NHC are prodrugs containing an amidoxime structure or mutagens such as 6-hydroxylaminopurine (HAP). We have studied this protein in the green alga Chlamydomonas reinhardtii (crARC). Interestingly, all the ARC proteins need the reducing power supplied by other proteins. It is known that crARC requires a cytochrome b₅ (crCytb5-1) and a cytochrome b₅ reductase (crCytb5-R) that form an electron transport chain from NADH to the substrates...
March 21, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28335532/separation-of-alkyne-enantiomers-by-chiral-column-hplc-analysis-of-their-cobalt-complexes
#2
Qiaoyun Liu, Jing Wang, Junfei Li, Xiaolei Wang, Shichao Lu, Xuan Li, Yaling Gong, Shu Xu
Separation of the enantiomers of new chiral alkynes in strategic syntheses and bioorthogonal studies is always problematic. The chiral column high-performance liquid chromatography (HPLC) method in general could not be directly used to resolve such substrates, since the differentiation of the alkyne segment with the other alkane/alkene segment is not significant in the stationary phase, and the alkyne group is not a good UV chromophore. Usually, a pre-column derivatization reaction with a tedious workup procedure is needed...
March 20, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28335483/land-use-for-edible-protein-of-animal-origin-a-review
#3
REVIEW
Gerhard Flachowsky, Ulrich Meyer, Karl-Heinz Südekum
The present period is characterized by a growing world population and a higher demand for more and better quality food, as well as other products for an improved standard of living. In the future, there will be increasingly strong competition for arable land and non-renewable resources such as fossil carbon-sources, water, and some minerals, as well as between food, feed, fuel, fiber, flowers, and fun (6 F's). Proteins of animal origin like milk, meat, fish, eggs and, probably, insects are very valuable sources of essential amino acids, minerals and vitamins, but their production consumes some non-renewable resources including arable land and causes considerable emissions...
March 18, 2017: Animals: An Open Access Journal From MDPI
https://www.readbyqxmd.com/read/28335238/selective-plasma-etching-of-polymeric-substrates-for-advanced-applications
#4
REVIEW
Harinarayanan Puliyalil, Uroš Cvelbar
In today's nanoworld, there is a strong need to manipulate and process materials on an atom-by-atom scale with new tools such as reactive plasma, which in some states enables high selectivity of interaction between plasma species and materials. These interactions first involve preferential interactions with precise bonds in materials and later cause etching. This typically occurs based on material stability, which leads to preferential etching of one material over other. This process is especially interesting for polymeric substrates with increasing complexity and a "zoo" of bonds, which are used in numerous applications...
June 7, 2016: Nanomaterials
https://www.readbyqxmd.com/read/28334991/frameworks-to-assess-health-systems-governance-a-systematic-review
#5
Thidar Pyone, Helen Smith, Nynke van den Broek
Governance of the health system is a relatively new concept and there are gaps in understanding what health system governance is and how it could be assessed. We conducted a systematic review of the literature to describe the concept of governance and the theories underpinning as applied to health systems; and to identify which frameworks are available and have been applied to assess health systems governance. Frameworks were reviewed to understand how the principles of governance might be operationalized at different levels of a health system...
March 3, 2017: Health Policy and Planning
https://www.readbyqxmd.com/read/28334776/structural-characterization-of-interactions-between-transactivation-domain-1-of-the-p65-subunit-of-nf-%C3%AE%C2%BAb-and-transcription-regulatory-factors
#6
Lauriane Lecoq, Luca Raiola, Philippe R Chabot, Normand Cyr, Geneviève Arseneault, Pascale Legault, James G Omichinski
p65 is a member of the NF-κB family of transcriptional regulatory proteins that functions as the activating component of the p65-p50 heterodimer. Through its acidic transactivation domain (TAD), p65 has the capacity to form interactions with several different transcriptional regulatory proteins, including TFIIB, TFIIH, CREB-binding protein (CBP)/p300 and TAFII31. Like other acidic TADs, the p65 TAD contains two subdomains (p65TA1 and p65TA2) that interact with different regulatory factors depending on the target gene...
February 28, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28334588/applying-the-chronic-care-model-to-improve-care-and-outcomes-at-a-pediatric-medical-center
#7
Jennifer Lail, Pamela J Schoettker, Denise L White, Bhavna Mehta, Uma R Kotagal
BACKGROUND: Cincinnati Children's Hospital Medical Center launched the Condition Outcomes Improvement Initiative in 2012 to help disease-based teams use the principles of improvement science to implement components of the Chronic Care Model and improve outpatient care delivery for populations of children with chronic and complex conditions. The goal was to improve outcomes by 20% from baseline. METHODS: Initiative activities included review of the evidence to choose and measure outcomes, development of condition-specific patient registries and tools for data collection, patient stratification, planning and coordinating care before and after visits, and self-management support...
March 2017: Joint Commission Journal on Quality and Patient Safety
https://www.readbyqxmd.com/read/28334581/a-gap-analysis-needs-assessment-tool-to-drive-a-care-delivery-and-research-agenda-for-integration-of-care-and-sharing-of-best-practices-across-a-health-system
#8
Sherita Hill Golden, Daniel Hager, Lois J Gould, Nestoras Mathioudakis, Peter J Pronovost
BACKGROUND: In a complex health system, it is important to establish a systematic and data-driven approach to identifying needs. The Diabetes Clinical Community (DCC) of Johns Hopkins Medicine's Armstrong Institute for Patient Safety and Quality developed a gap analysis tool and process to establish the system's current state of inpatient diabetes care. METHODS: The collectively developed tool assessed the following areas: program infrastructure; protocols, policies, and order sets; patient and health care professional education; and automated data access...
January 2017: Joint Commission Journal on Quality and Patient Safety
https://www.readbyqxmd.com/read/28334223/is-bamm-flawed-theoretical-and-practical-concerns-in-the-analysis-of-multi-rate-diversification-models
#9
Daniel L Rabosky, Jonathan S Mitchell, Jonathan Chang
BAMM (Bayesian Analysis of Macroevolutionary Mixtures) is a statistical framework that uses reversible jump MCMC to infer complex macroevolutionary dynamics of diversification and phenotypic evolution on phylogenetic trees. A recent article by Moore and coauthors (MEA) reported a number of theoretical and practical concerns with BAMM. Major claims from MEA are that (1) BAMM's likelihood function is incorrect, because it does not account for unobserved rate shifts; (2) the posterior distribution on the number of rate shifts is overly sensitive to the prior; and (3) diversification rate estimates from BAMM are unreliable...
February 21, 2017: Systematic Biology
https://www.readbyqxmd.com/read/28334033/a-qualitative-study-mothers-of-late-preterm-infants-relate-their-experiences-of-community-based-care
#10
Shahirose S Premji, Genevieve Currie, Sandra Reilly, Aliyah Dosani, Lynnette May Oliver, Abhay K Lodha, Marilyn Young
PURPOSE: In Alberta, the high occurrence of late preterm infants and early hospital discharge of mother-infant dyads has implications for postpartum care in the community. Shortened hospital stay and complexities surrounding the care of biologically and developmentally immature late preterm infants heighten anxiety and fears. Our descriptive phenomenological study explores mothers' experience of caring for their late preterm infants in the community. METHODS: Eleven mothers were interviewed using a semi-structured interview guide...
2017: PloS One
https://www.readbyqxmd.com/read/28334023/preferences-for-the-provision-of-whole-genome-sequencing-services-among-young-adults
#11
Christopher H Wade, Kailyn R Elliott
OBJECTIVES: As whole genome sequencing (WGS) becomes increasingly available, clinicians will be faced with conveying complex information to individuals at different stages in life. The purpose of this study is to characterize the views of young adults toward obtaining WGS, learning different types of genomic information, and having choice about which results are disclosed. METHODS: A mixed-methods descriptive study was conducted with a diverse group of 18 and 19-years-olds (N = 145)...
2017: PloS One
https://www.readbyqxmd.com/read/28333921/bioenergetics-based-modeling-of-plasmodium-falciparum-metabolism-reveals-its-essential-genes-nutritional-requirements-and-thermodynamic-bottlenecks
#12
Anush Chiappino-Pepe, Stepan Tymoshenko, Meriç Ataman, Dominique Soldati-Favre, Vassily Hatzimanikatis
Novel antimalarial therapies are urgently needed for the fight against drug-resistant parasites. The metabolism of malaria parasites in infected cells is an attractive source of drug targets but is rather complex. Computational methods can handle this complexity and allow integrative analyses of cell metabolism. In this study, we present a genome-scale metabolic model (iPfa) of the deadliest malaria parasite, Plasmodium falciparum, and its thermodynamics-based flux analysis (TFA). Using previous absolute concentration data of the intraerythrocytic parasite, we applied TFA to iPfa and predicted up to 63 essential genes and 26 essential pairs of genes...
March 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/28333695/pulmonary-manifestations-of-rheumatologic-diseases
#13
Michal Cidon, Manvi Bansal, Dominik Hartl
PURPOSE OF REVIEW: The present review intends to provide an overview of the diversity and complexity of pulmonary manifestations of rheumatologic diseases and gaps in knowledge to effectively manage them. RECENT FINDINGS: Diffuse lung disease in children with rheumatologic diseases represents a heterogeneous group of autoimmune disorders. Despite their significant morbidity and mortality, we have limited understanding about their pathogenesis. Here, we provide an overview of the pathophysiology and current management approach of these disorders, highlighting tools which assist with diagnosis, risk stratification and therapy...
March 22, 2017: Current Opinion in Pediatrics
https://www.readbyqxmd.com/read/28333624/a-fast-and-robust-beamspace-adaptive-beamformer-for-medical-ultrasound-imaging
#14
Ali Mohades Deylami, Babak Mohammadzadeh Asl
Minimum variance beamformer (MVB) increases the resolution and contrast of medical ultrasound imaging compared to non-adaptive beamformers. These advantages come at the expense of high computational complexity that prevents this adaptive beamformer to be applied in a real-time imaging system. A new beamspace based on discrete cosine transform (DCT) is proposed in which the medical ultrasound signals can be represented with less dimensions compared to the standard beamspace. This is because of symmetric beampattern of the beams in the proposed beamspace compared to the asymmetric ones in the standard beamspace...
March 21, 2017: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
https://www.readbyqxmd.com/read/28333583/an-approximation-of-the-error-backpropagation-algorithm-in-a-predictive-coding-network-with-local-hebbian-synaptic-plasticity
#15
James C R Whittington, Rafal Bogacz
To efficiently learn from feedback, cortical networks need to update synaptic weights on multiple levels of cortical hierarchy. An effective and well-known algorithm for computing such changes in synaptic weights is the error backpropagation algorithm. However, in this algorithm, the change in synaptic weights is a complex function of weights and activities of neurons not directly connected with the synapse being modified, whereas the changes in biological synapses are determined only by the activity of presynaptic and postsynaptic neurons...
March 23, 2017: Neural Computation
https://www.readbyqxmd.com/read/28333429/multimodality-imaging-to-plan-and-guide-transcatheter-tricuspid-valve-interventions
#16
Edgard A Prihadi, Victoria Delgado, Jeroen J Bax
Tricuspid regurgitation (TR) is a highly prevalent valvular heart disease. The natural history of untreated significant TR portends an unfavourable outcome, but only a minority of patients is currently referred for surgical treatment. Organic TR (caused by primary abnormality of the leaflets) is relatively infrequent whereas secondary or functional TR (caused by dilatation of the tricuspid annulus, right ventricle [RV] and right atrium) is the predominant mechanism. The success of transcatheter therapies for left valvular heart disease over the last decade, has fuelled similar development of novel transcatheter devices for the treatment of TR...
March 23, 2017: Minerva Cardioangiologica
https://www.readbyqxmd.com/read/28333333/why-aren-t-women-choosing-stem-academic-jobs-observations-from-a-small-group-discussion-at-the-2016-american-society-for-microbiology-annual-meeting
#17
Elizabeth M Adamowicz
This commentary summarizes a small-group discussion that recently occurred at the American Society for Microbiology annual general meeting, ASM Microbe, in Boston, Massachusetts on June 16-20, 2016, on the topic 'why are so few women choosing to become academics?' Specifically, the discussion focused on asking what the actual and perceived barriers to academic STEM careers women face, and possible solutions to address them which would make women more likely to seek out academic careers. The conclusions reached suggest that, despite improvement in recent years, women and minorities still face complex barriers to STEM academic careers, and further research is needed to determine the best solutions to this problem...
March 15, 2017: FEMS Microbiology Letters
https://www.readbyqxmd.com/read/28333312/establishment-maintenance-and-functional-integrity-of-the-blood-testis-barrier-in-organotypic-cultures-of-fresh-and-frozen-thawed-prepubertal-mouse-testes
#18
C Rondanino, A Maouche, L Dumont, A Oblette, N Rives
STUDY QUESTION: Can the spatio-temporal formation of an intact blood-testis barrier (BTB), which is essential for the progression of spermatogenesis, be reproduced in cultures of fresh or frozen/thawed prepubertal mouse testes? SUMMARY ANSWER: Organotypic cultures allow the establishment and maintenance of major BTB components and the formation of a functional BTB in mouse testicular tissues. WHAT IS KNOWN ALREADY: In vitro maturation of prepubertal testicular tissues is a promising approach to restore fertility in adult survivors of childhood cancer...
March 17, 2017: Molecular Human Reproduction
https://www.readbyqxmd.com/read/28333272/family-building-using-embryo-adoption-relationships-and-contact-arrangements-between-provider-and-recipient-families-a-mixed-methods-study
#19
Lucy Frith, Eric Blyth, Steve Lui
STUDY QUESTION: What contact arrangements are established between providers and recipients of embryos using Snowflakes® Embryo Adoption Program? SUMMARY ANSWER: Contact arrangements varied considerably and were generally positively described, although some challenges were acknowledged. WHAT IS KNOWN ALREADY: Reproductive technologies create new and diverse family forms, and the ways in which families created by embryo adoption are negotiated in practice have not been extensively investigated...
March 8, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28333195/genome-wide-genetic-analyses-highlight-mitogen-activated-protein-kinase-mapk-signaling-in-the-pathogenesis-of-endometriosis
#20
Outi Uimari, Nilufer Rahmioglu, Dale R Nyholt, Katy Vincent, Stacey A Missmer, Christian Becker, Andrew P Morris, Grant W Montgomery, Krina T Zondervan
STUDY QUESTION: Do genome-wide association study (GWAS) data for endometriosis provide insight into novel biological pathways associated with its pathogenesis? SUMMARY ANSWER: GWAS analysis uncovered multiple pathways that are statistically enriched for genetic association signals, analysis of Stage A disease highlighted a novel variant in MAP3K4, while top pathways significantly associated with all endometriosis and Stage A disease included several mitogen-activated protein kinase (MAPK)-related pathways...
February 9, 2017: Human Reproduction
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