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Mihir M Sheth, Daniel Sholder, Joseph Abboud, Mark D Lazarus, Matthew L Ramsey, Gerald R Williams, Surena Namdari
BACKGROUND: The impending burden of revision shoulder arthroplasty has increased interest in outcomes of revision procedures. Painful glenoid arthrosis following hemiarthroplasty is a common cause of reoperation, and conversion to anatomic total shoulder arthroplasty is one option. METHODS: We identified patients who underwent revision of painful hemiarthroplasty to total shoulder arthroplasty over a 15-year period in a single tertiary-care health system. Presurgical and operative data were analyzed for 28 patients who met the inclusion and exclusion criteria...
May 10, 2018: Journal of Shoulder and Elbow Surgery
Michael Livesey, John G Horneff, Daniel Sholder, Mark Lazarus, Gerald Williams, Surena Namdari
A well-functioning rotator cuff is necessary for successful anatomic total shoulder arthroplasty (TSA). This study evaluated patients who underwent concomitant TSA and rotator cuff repair (RCR) for functional outcomes, revision rates, and predictors of poor results. Retrospective chart review was conducted to identify patients who underwent TSA and RCR. Demographic data, rotator cuff tear and RCR characteristics, range of motion, and radiographs were recorded. Minimum 2-year functional outcomes were obtained...
May 1, 2018: Orthopedics
Adam Seidl, Daniel Sholder, William Warrender, Michael Livesey, Gerald Williams, Joseph Abboud, Surena Namdari
BACKGROUND: This study compared the outcomes between patients with proximal humerus fractures (PHF) who underwent acute reverse total shoulder arthroplasty (RSA) to those who underwent an alternative initial treatment before requiring (secondary) RSA. METHODS: Patients who underwent RSA after suffering a PHF were identified. Two year clinical follow-up was required for inclusion. Patients were divided into an acute group (RSA <4 weeks of fracture) and a secondary group...
July 2017: Archives of Bone and Joint Surgery
Daniel E Davis, Alexa Narzikul, Daniel Sholder, Mark Lazarus, Surena Namdari, Joseph Abboud
INTRODUCTION: Rotator cuff pathology has been proposed to occur through intrinsic and extrinsic mechanisms. Hyperlipidemia has been proposed as a mechanism of intrinsic rotator cuff pathology. This prospective observational study evaluates serum and synovial lipid profiles in patients with and without rotator cuff tears to further define the relationship of cholesterol and rotator cuff pathology. METHODS: Patients were prospectively enrolled with intact rotator cuff (37 patients) and rotator cuff tear requiring a repair (40 patients) groups...
March 2017: Medicine and Science in Sports and Exercise
Callista L Costopoulos, Joseph A Abboud, Matthew L Ramsey, Charles L Getz, Daniel S Sholder, John P Taras, Daniel Huttman, Mark D Lazarus
BACKGROUND: This study evaluated the incidence of symptomatic radioulnar synostosis/heterotopic ossification after distal biceps tendon repair in patients receiving indomethacin prophylaxis. We hypothesized that indomethacin use postoperatively would decrease the occurrence of symptomatic synostosis. METHODS: A single-center retrospective record review identified 124 patients undergoing distal biceps repair between 2011 and 2014. Patients were analyzed for administration of indomethacin, contraindications to administration, age, time to surgery, fixation method, medical comorbidities, and development of symptomatic synostosis...
February 2017: Journal of Shoulder and Elbow Surgery
Jia-Wei Kevin Ko, Jeffrey D Tompson, Daniel S Sholder, Eric M Black, Joseph A Abboud
BACKGROUND: Heterotopic ossification (HO) around shoulder arthroplasty is a frequent finding with unclear clinical relevance. This study evaluated the incidence, relevance, and predisposing factors of HO in the long head of the triceps tendon after reverse shoulder arthroplasty. METHODS: Retrospective chart review was conducted to identify patients who had a reverse shoulder arthroplasty performed between 2008 and 2012. Patient demographics, implant types, and diagnoses were noted...
November 2016: Journal of Shoulder and Elbow Surgery
Gabriel Sholder, Amanda Creech, Edward L Loechler
To bypass DNA damage, cells have Y-Family DNA polymerases (DNAPs). One Y-Family-class includes DNAP κ and DNAP IV, which accurately insert dCTP opposite N(2)-dG adducts, including from the carcinogen benzo[a]pyrene (BP). Another class includes DNAP η and DNAP V, which insert accurately opposite UV-damage, but inaccurately opposite BP-N(2)-dG. To investigate structural differences between Y-Family-classes, regions are swapped between DNAP IV (a κ/IV-class-member) and Dpo4 (a η/V-class-member); the kinetic consequences are evaluated via primer-extension studies with a BP-N(2)-dG-containing template...
November 2015: DNA Repair
Gabriel Sholder, Edward L Loechler
Quantitating relative (32)P-band intensity in gels is desired, e.g., to study primer-extension kinetics of DNA polymerases (DNAPs). Following imaging, multiple (32)P-bands are often present in lanes. Though individual bands appear by eye to be simple and well-resolved, scanning reveals they are actually skewed-Gaussian in shape and neighboring bands are overlapping, which complicates quantitation, because slower migrating bands often have considerable contributions from the trailing edges of faster migrating bands...
January 2015: DNA Repair
Aaron J Sholders, Olve B Peersen
The mechanism whereby RNA is translocated by the single subunit viral RNA-dependent RNA polymerases is not yet understood. These enzymes lack homologs of the "O-helix" structures and associated fingers domain movements thought to be responsible for translocation in many DNA-templated polymerases. The structures of multiple picornavirus polymerase elongation complexes suggest that these enzymes use a different molecular mechanism where translocation is not strongly coupled to the opening of the active site following catalysis...
April 3, 2014: Journal of Molecular Biology
Peng Gong, Grace Campagnola, Olve B Peersen
The measurement of nucleic acid polymerase elongation rates is often done via a lengthy experimental process involving radiolabeled substrates, quenched elongation experiments, electrophoretic product separation, and band quantitation. In this work, we describe an alternative real-time stopped-flow assay for obtaining kinetic parameters for elongation of extended sequences. The assay builds on our earlier PETE (polymerase elongation template element) assay designed for high-throughput screening purposes [S...
August 1, 2009: Analytical Biochemistry
John W Tullai, Michael E Schaffer, Steven Mullenbrock, Gabriel Sholder, Simon Kasif, Geoffrey M Cooper
The transcriptional program induced by growth factor stimulation is classically described in two stages as follows: the rapid protein synthesis-independent induction of immediate-early genes, followed by the subsequent protein synthesis-dependent induction of secondary response genes. In this study, we obtained a comprehensive view of this transcriptional program. As expected, we identified both rapid and delayed gene inductions. Surprisingly, however, a large fraction of genes induced with delayed kinetics did not require protein synthesis and therefore represented delayed primary rather than secondary response genes...
August 17, 2007: Journal of Biological Chemistry
Santano P Mestas, Aaron J Sholders, Olve B Peersen
We have devised a simple high-throughput screening compatible fluorescence polarization-based assay that can be used to detect the elongation activity of nucleic acid polymerase enzymes. The assay uses a 5' end-labeled template strand and relies on an increase in the polarization signal from the fluorescent label as it is drawn in toward the active site by the action of the enzyme. If the oligonucleotide is sufficiently short, the fluorescence polarization signal can also be used to detect binding prior to elongation activity...
June 15, 2007: Analytical Biochemistry
V Martić, P Perić
In the group of patients with carpal tunnel syndrome (CTS), besides paresthesias in their fingers, we can see paresthesias in forearm; pain in elbow, sholder and neck, which is a reason for complicated diagnosis of it. This kind of complexnost of differential diagnosis pain in hand, is a reason for complet and strict diagnostic procedure. There are 30 patients with clinical and neurophysological findings for CTS in this paper who made provocative tests. Analising their results we made diagnosis of KTS.
2004: Acta Chirurgica Iugoslavica
Kathleen M Campbell, Aaron J Sholders, Kevin J Lumb
Coiled coils comprise two or more helices characterized by a heptad repeat of amino acids denoted a through g. The buried a and d positions are usually occupied by hydrophobic residues. Fos dimerizes via a coiled coil (leucine zipper) with Jun family members to form the transcription factor AP-1. Fos homodimers are relatively unstable due to unfavorable interhelical electrostatic interactions within the Fos two-stranded coiled coil. The Fos coiled coil contains two polar position a Lys residues (Lys 16 and Lys 30 of Fos-p1, a peptide corresponding to the coiled-coil domain of v-Fos)...
April 16, 2002: Biochemistry
B R Konety, T S Nguyen, G Brenes, A Sholder, N Lewis, S Bastacky, D M Potter, R H Getzenberg
PURPOSE: Previous studies at our laboratory identified 6 bladder cancer specific nuclear matrix proteins termed BLCA-1 to 6. We recently developed an immunoassay that detects the bladder cancer specific nuclear matrix protein BLCA-4. We analyzed urine samples from patients with bladder cancer, those with spinal cord injury and normal volunteers to determine the BLCA-4 level in these 3 groups. MATERIALS AND METHODS: Urine samples obtained from 51 normal controls, and 54 patients with bladder cancer and 202 with spinal cord injury were tested for BLCA-4...
September 2000: Journal of Urology
S Mortazavi, E Park, J Florio, J Poore, G Bornzin, P A Levine, J Sholder
Two advances in cardiac pacing have resulted in an internal conflict in some pacemakers. One is the development of a standard lead physiological sensor and the other is protection from electromagnetic interference (EMI). One popular type of standard lead sensor uses sub-threshold pulses to measure intracardiac and intrathoracic impedance changes, i.e., minute ventilation. Recent clinical observations and extensive in vitro testing have verified that digital cellular phones can be troublesome. Large feedthrough capacitors (FCs), effective in blocking the EMI, will preclude sensing of the standard impedance-based signals...
November 1996: Pacing and Clinical Electrophysiology: PACE
P A Levine, G A Bornzin, J Barlow, J Florio, J Sholder, J Tyler, B Mann
Patients with complete heart block on a spontaneous, or iatrogenic basis who also have recurrent supraventricular tachycardias, particularly atrial fibrillation and flutter, are often difficult to manage. Various techniques include: independently programmable maximum tracking and maximum sensor rates, limiting the maximum atrial tracking rate to the sensor response of the pacemaker, or automatically switching from DDDR to VVIR based upon the sensed atrial rate. This article will describe a mode switch algorithm that allows for an independently programmable atrial tachycardia detection rate (ATDR)...
November 1994: Pacing and Clinical Electrophysiology: PACE
D A Sholder
To discover whether the American woman has a preconceived idea of her newborn's appearance, ten primigravidas were asked to draw their newborns-to-be and were interviewed about their expectations. Responses were analyzed for recurring themes and compared with a stereotypical baby described by Lorenz. The informants' general descriptions of their newborns-to-be were specific to the particular family. The newborns were closer in appearance to an older baby than to a newborn. The informants' newborns had two of the Lorenz's six stereotypical attributes...
March 1981: JOGN Nursing; Journal of Obstetric, Gynecologic, and Neonatal Nursing
A Sholder, M Maizels, C F Firlit
The cecoureterocele differs from the usual ectopic ureterocele because it extends outside the bladder and may obstruct the urethra. The differentiation requires careful examination of the urethra by a voiding cystourethrogram and cystoscopy. We describe the management of a girl with bilateral cecoureteroceles who presented as a newborn with urinary retention and sepsis. Surgical correction of the cecoureterocele may differ from that required for the usual ectopic ureterocele.
December 1983: Journal of Urology
P A Levine, J Sholder, J L Duncan
The advent of telemetry of the endocardial electrogram is a new capability. It must be convenient to use if it is to gain acceptance. Our experience is still growing but already it is confirming information that was either deduced or previously only available by active invasive procedures. The potential value of the technology has only been touched upon in this presentation. We are convinced that it will grow and that its value will be further established as more physicians have an opportunity to use it and gain additional experience...
November 1984: Pacing and Clinical Electrophysiology: PACE
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