keyword
https://read.qxmd.com/read/35064337/early-revision-rotator-cuff-repair-an-analysis-of-outcomes-and-function
#1
JOURNAL ARTICLE
Joseph G Monir, Matthew M Astolfi, Daniel Sholder, Nikola Kocovic, J Gabriel Horneff, Joseph A Abboud, Bradley S Schoch
PURPOSE: Rotator cuff repair (RCR) is commonly performed and can have good functional outcomes. However, failure of RCR surgery can be challenging for both patient and surgeon alike. This study examines the outcomes of early revision RCR for the management of clinically failed RCRs. METHODS: Thirty-six patients undergoing revision RCR within 1 year of primary surgery were evaluated. Range of motion (ROM) and patient-reported outcomes (PROMs) were assessed at baseline, post-primary RCR, and post-revision RCR...
January 22, 2022: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://read.qxmd.com/read/33345217/concomitant-rotator-cuff-repair-and-instability-surgery-provide-good-patient-reported-functional-outcomes-in-patients-aged-40-years-or-older-with-shoulder-dislocation
#2
JOURNAL ARTICLE
Wayne W Chan, Tyler J Brolin, Ocean Thakar, Manan S Patel, Daniel S Sholder, Joseph A Abboud, Charles L Getz
BACKGROUND: Recurrent anterior shoulder dislocation in patients aged ≥ 40 years is not as rare as once thought. The mechanism of instability in this patient population is different-more likely to be attributed to rotator cuff pathology-compared with that in younger individuals. With an increasingly aging active population, surgical management has a rising role in preventing morbidity associated with recurrent instability. Our purpose was to evaluate outcomes of anterior shoulder instability repair (ie, Bankart or bony Bankart repair) with and without rotator cuff repair (RCR) in patients aged ≥ 40 years...
December 2020: JSES international
https://read.qxmd.com/read/32713669/radiographic-humeral-head-restoration-after-total-shoulder-arthroplasty-does-the-stem-make-a-difference
#3
JOURNAL ARTICLE
Ryan M Cox, Daniel Sholder, Laura Stoll, Joseph A Abboud, Gerald R Williams, Matthew L Ramsey, Mark D Lazarus, John G Horneff
BACKGROUND: Humeral stem designs for total shoulder arthroplasty have varied over the years, with a recent trend toward shorter stems. The purpose of this study was to examine the impact of humeral component stem length on the ability to restore the native humeral head anatomy. METHODS: We performed a retrospective review including patients who underwent total shoulder arthroplasty for primary osteoarthritis between 2007 and 2017 with complete operative reports and adequate radiographs...
January 2021: Journal of Shoulder and Elbow Surgery
https://read.qxmd.com/read/32490044/revision-of-anatomic-total-shoulder-arthroplasty-to-hemiarthroplasty-does-it-work
#4
JOURNAL ARTICLE
Mihir Sheth, Daniel Sholder, Joseph Abboud, Mark Lazarus, Gerald Williams, Surena Namdari
BACKGROUND: The projected increase in revision shoulder arthroplasty has increased interest in the outcomes of these procedures. Glenoid component removal and conversion to a hemiarthroplasty (HA) is an option for aseptic glenoid loosening after anatomic total shoulder arthroplasty (aTSA). METHODS: We identified patients who had undergone revision shoulder arthroplasty over a 15-year period. 17 patients met inclusion and exclusion criteria, and a retrospective chart review was conducted for pre-surgical and operative data...
March 2020: Archives of Bone and Joint Surgery
https://read.qxmd.com/read/31196509/the-distress-and-risk-assessment-method-predicts-postoperative-narcotic-use-in-patients-undergoing-rotator-cuff-repair
#5
JOURNAL ARTICLE
Jason S Klein, Daniel E Davis, Zach S Wells, Liam T Kane, Daniel Sholder, Surena Namdari, Joseph A Abboud
BACKGROUND: The Distress and Risk Assessment Method (DRAM) predicts poor outcomes in spine, hip, and knee surgery. Unlike other areas of orthopedic surgery, DRAM scores are not predictive of lower postoperative patient-reported outcomes after arthroscopic rotator cuff repair (RCR). PURPOSE: As concerns for opioid dependence and abuse grow, the purpose of this study was to analyze the correlation between preoperative DRAM scores, modified Zung scores, and postoperative narcotic use in patients who underwent arthroscopic RCR...
June 2019: Journal of Shoulder and Elbow Surgery
https://read.qxmd.com/read/30805411/failure-of-anatomic-total-shoulder-arthroplasty-with-revision-to-another-anatomic-total-shoulder-arthroplasty
#6
JOURNAL ARTICLE
Mihir Sheth, Daniel Sholder, Eric M Padegimas, Thema A Nicholson, Charles L Getz, Matthew L Ramsey, Gerald R Williams, Surena Namdari
BACKGROUND: While outcomes of primary anatomic total shoulder arthroplasty (aTSA) are generally favorable, results after revision procedures are less reliable. This study examines the functional outcomes, complications, and implant survival in patients who underwent revision of aTSA to aTSA. METHODS: Patients who underwent revision aTSA were identified from 2008-2015. Demographic, clinical, surgical, and outcomes data were analyzed. Patient-reported outcomes including the American Shoulder and Elbow Surgeons Score (ASES), Single Assessment Numerical Evaluation (SANE), Visual Analog Scale for pain (VAS), the Short Form-12 Health Survey (SF-12), and patient satisfaction were recorded...
January 2019: Archives of Bone and Joint Surgery
https://read.qxmd.com/read/30713064/revision-of-failed-hemiarthroplasty-and-anatomic-total-shoulder-arthroplasty-to-reverse-total-shoulder-arthroplasty
#7
JOURNAL ARTICLE
Mihir M Sheth, Daniel Sholder, Charles L Getz, Gerald R Williams, Surena Namdari
BACKGROUND: The impending burden of revision shoulder arthroplasty has increased interest in outcomes of revision procedures. Revision of failed anatomic arthroplasty to reverse total shoulder arthroplasty has shown promise alongside concerning complication rates. METHODS: Patients who underwent revision shoulder arthroplasty during a 7-year period at a tertiary care health system were identified. Presurgical and operative data were analyzed for 110 patients who met inclusion and exclusion criteria...
June 2019: Journal of Shoulder and Elbow Surgery
https://read.qxmd.com/read/30175175/identification-of-risk-factors-for-abnormal-postoperative-chemistry-labs-after-primary-shoulder-arthroplasty
#8
JOURNAL ARTICLE
Alexis A Williams, Eric H Tischler, Daniel Sholder, Thema A Nicholson, Mitchell G Maltenfort, Charles Getz, Gerald Williams, Surena Namdari
BACKGROUND: The purpose of this study was to determine patient-specific risk factors and clinical intervention rates for abnormal postoperative Chem-7 panels in shoulder arthroplasty patients. METHODS: Retrospectively, all primary anatomic total (aTSA) and reverse shoulder (RTSA) arthroplasties (between 2007-2013) performed at a single institution were identified. All patients underwent routine preoperative and postoperative day one (POD1) chemistry panels. Each clinically significant component of the Chem-7 panel was independently evaluated using a multivariate analysis to identify risk factors for abnormal results...
July 2018: Archives of Bone and Joint Surgery
https://read.qxmd.com/read/30016693/culture-positivity-in-primary-total-shoulder-arthroplasty
#9
JOURNAL ARTICLE
Justin C Wong, Bradley S Schoch, Brian K Lee, Daniel Sholder, Thema Nicholson, Surena Namdari, Charles L Getz, Mark D Lazarus, Matthew L Ramsey, Gerald R Williams, Joseph A Abboud
BACKGROUND: The clinical significance of positive cultures in shoulder surgery remains unclear. This study determined the rate and characteristics of positive intraoperative cultures in a cohort of patients undergoing primary shoulder arthroplasty. METHODS: From February 2015 to March 2016, 94 patients, without prior surgery, underwent primary shoulder arthroplasty. Before surgery, all shoulders were prospectively enrolled and consented to obtain standardized intraoperative cultures...
August 2018: Journal of Shoulder and Elbow Surgery
https://read.qxmd.com/read/29754843/revision-of-failed-hemiarthroplasty-for-painful-glenoid-arthrosis-to-anatomic-total-shoulder-arthroplasty
#10
JOURNAL ARTICLE
Mihir M Sheth, Daniel Sholder, Joseph Abboud, Mark D Lazarus, Matthew L Ramsey, Gerald R Williams, Surena Namdari
BACKGROUND: The impending burden of revision shoulder arthroplasty has increased interest in outcomes of revision procedures. Painful glenoid arthrosis following hemiarthroplasty is a common cause of reoperation, and conversion to anatomic total shoulder arthroplasty is one option. METHODS: We identified patients who underwent revision of painful hemiarthroplasty to total shoulder arthroplasty over a 15-year period in a single tertiary-care health system. Presurgical and operative data were analyzed for 28 patients who met the inclusion and exclusion criteria...
October 2018: Journal of Shoulder and Elbow Surgery
https://read.qxmd.com/read/29494745/functional-outcomes-and-predictors-of-failure-after-rotator-cuff-repair-during-total-shoulder-arthroplasty
#11
JOURNAL ARTICLE
Michael Livesey, John G Horneff, Daniel Sholder, Mark Lazarus, Gerald Williams, Surena Namdari
A well-functioning rotator cuff is necessary for successful anatomic total shoulder arthroplasty (TSA). This study evaluated patients who underwent concomitant TSA and rotator cuff repair (RCR) for functional outcomes, revision rates, and predictors of poor results. Retrospective chart review was conducted to identify patients who underwent TSA and RCR. Demographic data, rotator cuff tear and RCR characteristics, range of motion, and radiographs were recorded. Minimum 2-year functional outcomes were obtained...
May 1, 2018: Orthopedics
https://read.qxmd.com/read/28913377/early-versus-late-reverse-shoulder-arthroplasty-for-proximal-humerus-fractures-does-it-matter
#12
JOURNAL ARTICLE
Adam Seidl, Daniel Sholder, William Warrender, Michael Livesey, Gerald Williams, Joseph Abboud, Surena Namdari
BACKGROUND: This study compared the outcomes between patients with proximal humerus fractures (PHF) who underwent acute reverse total shoulder arthroplasty (RSA) to those who underwent an alternative initial treatment before requiring (secondary) RSA. METHODS: Patients who underwent RSA after suffering a PHF were identified. Two year clinical follow-up was required for inclusion. Patients were divided into an acute group (RSA <4 weeks of fracture) and a secondary group...
July 2017: Archives of Bone and Joint Surgery
https://read.qxmd.com/read/28212263/shoulder-synovial-fluid-lipoprotein-levels-and-their-relationship-to-the-rotator-cuff
#13
JOURNAL ARTICLE
Daniel E Davis, Alexa Narzikul, Daniel Sholder, Mark Lazarus, Surena Namdari, Joseph Abboud
INTRODUCTION: Rotator cuff pathology has been proposed to occur through intrinsic and extrinsic mechanisms. Hyperlipidemia has been proposed as a mechanism of intrinsic rotator cuff pathology. This prospective observational study evaluates serum and synovial lipid profiles in patients with and without rotator cuff tears to further define the relationship of cholesterol and rotator cuff pathology. METHODS: Patients were prospectively enrolled with intact rotator cuff (37 patients) and rotator cuff tear requiring a repair (40 patients) groups...
March 2017: Medicine and Science in Sports and Exercise
https://read.qxmd.com/read/28104092/the-use-of-indomethacin-in-the-prevention-of-postoperative-radioulnar-synostosis-after-distal-biceps-repair
#14
JOURNAL ARTICLE
Callista L Costopoulos, Joseph A Abboud, Matthew L Ramsey, Charles L Getz, Daniel S Sholder, John P Taras, Daniel Huttman, Mark D Lazarus
BACKGROUND: This study evaluated the incidence of symptomatic radioulnar synostosis/heterotopic ossification after distal biceps tendon repair in patients receiving indomethacin prophylaxis. We hypothesized that indomethacin use postoperatively would decrease the occurrence of symptomatic synostosis. METHODS: A single-center retrospective record review identified 124 patients undergoing distal biceps repair between 2011 and 2014. Patients were analyzed for administration of indomethacin, contraindications to administration, age, time to surgery, fixation method, medical comorbidities, and development of symptomatic synostosis...
February 2017: Journal of Shoulder and Elbow Surgery
https://read.qxmd.com/read/27260996/heterotopic-ossification-of-the-long-head-of-the-triceps-after-reverse-total-shoulder-arthroplasty
#15
JOURNAL ARTICLE
Jia-Wei Kevin Ko, Jeffrey D Tompson, Daniel S Sholder, Eric M Black, Joseph A Abboud
BACKGROUND: Heterotopic ossification (HO) around shoulder arthroplasty is a frequent finding with unclear clinical relevance. This study evaluated the incidence, relevance, and predisposing factors of HO in the long head of the triceps tendon after reverse shoulder arthroplasty. METHODS: Retrospective chart review was conducted to identify patients who had a reverse shoulder arthroplasty performed between 2008 and 2012. Patient demographics, implant types, and diagnoses were noted...
November 2016: Journal of Shoulder and Elbow Surgery
https://read.qxmd.com/read/26523515/how-y-family-dna-polymerase-iv-is-more-accurate-than-dpo4-at-dctp-insertion-opposite-an-n2-dg-adduct-of-benzo-a-pyrene
#16
JOURNAL ARTICLE
Gabriel Sholder, Amanda Creech, Edward L Loechler
To bypass DNA damage, cells have Y-Family DNA polymerases (DNAPs). One Y-Family-class includes DNAP κ and DNAP IV, which accurately insert dCTP opposite N(2)-dG adducts, including from the carcinogen benzo[a]pyrene (BP). Another class includes DNAP η and DNAP V, which insert accurately opposite UV-damage, but inaccurately opposite BP-N(2)-dG. To investigate structural differences between Y-Family-classes, regions are swapped between DNAP IV (a κ/IV-class-member) and Dpo4 (a η/V-class-member); the kinetic consequences are evaluated via primer-extension studies with a BP-N(2)-dG-containing template...
November 2015: DNA Repair
https://read.qxmd.com/read/25497330/a-method-to-accurately-quantitate-intensities-of-32-p-dna-bands-when-multiple-bands-appear-in-a-single-lane-of-a-gel-is-used-to-study-dntp-insertion-opposite-a-benzo-a-pyrene-dg-adduct-by-sulfolobus-dna-polymerases-dpo4-and-dbh
#17
JOURNAL ARTICLE
Gabriel Sholder, Edward L Loechler
Quantitating relative (32)P-band intensity in gels is desired, e.g., to study primer-extension kinetics of DNA polymerases (DNAPs). Following imaging, multiple (32)P-bands are often present in lanes. Though individual bands appear by eye to be simple and well-resolved, scanning reveals they are actually skewed-Gaussian in shape and neighboring bands are overlapping, which complicates quantitation, because slower migrating bands often have considerable contributions from the trailing edges of faster migrating bands...
January 2015: DNA Repair
https://read.qxmd.com/read/24424421/distinct-conformations-of-a-putative-translocation-element-in-poliovirus-polymerase
#18
COMMENT
Aaron J Sholders, Olve B Peersen
The mechanism whereby RNA is translocated by the single subunit viral RNA-dependent RNA polymerases is not yet understood. These enzymes lack homologs of the "O-helix" structures and associated fingers domain movements thought to be responsible for translocation in many DNA-templated polymerases. The structures of multiple picornavirus polymerase elongation complexes suggest that these enzymes use a different molecular mechanism where translocation is not strongly coupled to the opening of the active site following catalysis...
April 3, 2014: Journal of Molecular Biology
https://read.qxmd.com/read/19406094/a-quantitative-stopped-flow-fluorescence-assay-for-measuring-polymerase-elongation-rates
#19
JOURNAL ARTICLE
Peng Gong, Grace Campagnola, Olve B Peersen
The measurement of nucleic acid polymerase elongation rates is often done via a lengthy experimental process involving radiolabeled substrates, quenched elongation experiments, electrophoretic product separation, and band quantitation. In this work, we describe an alternative real-time stopped-flow assay for obtaining kinetic parameters for elongation of extended sequences. The assay builds on our earlier PETE (polymerase elongation template element) assay designed for high-throughput screening purposes [S...
August 1, 2009: Analytical Biochemistry
https://read.qxmd.com/read/17575275/immediate-early-and-delayed-primary-response-genes-are-distinct-in-function-and-genomic-architecture
#20
COMPARATIVE STUDY
John W Tullai, Michael E Schaffer, Steven Mullenbrock, Gabriel Sholder, Simon Kasif, Geoffrey M Cooper
The transcriptional program induced by growth factor stimulation is classically described in two stages as follows: the rapid protein synthesis-independent induction of immediate-early genes, followed by the subsequent protein synthesis-dependent induction of secondary response genes. In this study, we obtained a comprehensive view of this transcriptional program. As expected, we identified both rapid and delayed gene inductions. Surprisingly, however, a large fraction of genes induced with delayed kinetics did not require protein synthesis and therefore represented delayed primary rather than secondary response genes...
August 17, 2007: Journal of Biological Chemistry
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