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https://www.readbyqxmd.com/read/29530527/stimulation-of-white-adipose-tissue-lipolysis-by-xenin-a-neurotensin-related-peptide
#1
Sharma Bhavya, Pei San Lew, Tooru M Mizuno
Xenin is a gastrointestinal hormone that belongs to the neurotensin family. Central administration of xenin to obese mice reduces food intake and body weight gain and causes alterations in the expression of lipid metabolism-related genes and proteins in white adipose tissue (WAT). However, it has not been tested whether or not xenin directly acts on adipose tissue and alters lipid metabolism. The present study was performed to address this possibility by examining the effect of xenin treatment on the levels of glycerol and free fatty acids (FFA) and expression levels of lipolysis marker proteins ex vivo in cultured mouse WAT...
April 15, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29505574/treatment-of-infected-lungs-by-ex-vivo-perfusion-with-high-dose-antibiotics-and-autotransplantation-a-pilot-study-in-pigs
#2
Norman Zinne, Marcus Krueger, Doris Hoeltig, Burkhard Tuemmler, Erin C Boyle, Christian Biancosino, Klaus Hoeffler, Peter Braubach, Taufiek K Rajab, Anatol Ciubotaru, Judith Rohde, Karl-Heinz Waldmann, Axel Haverich
The emergence of multi-drug resistant bacteria threatens to end the era of antibiotics. Drug resistant bacteria have evolved mechanisms to overcome antibiotics at therapeutic doses and further dose increases are not possible due to systemic toxicity. Here we present a pilot study of ex vivo lung perfusion (EVLP) with high dose antibiotic therapy followed by autotransplantation as a new therapy of last resort for otherwise incurable multidrug resistant lung infections. Severe Pseudomonas aeruginosa pneumonia was induced in the lower left lungs (LLL) of 18 Mini-Lewe pigs...
2018: PloS One
https://www.readbyqxmd.com/read/29320996/healthy-apple-program-to-support-child-care-centers-to-alter-nutrition-and-physical-activity-practices-and-improve-child-weight-a-cluster-randomized-trial
#3
RANDOMIZED CONTROLLED TRIAL
Jodi D Stookey, Jane Evans, Curtis Chan, Lisa Tao-Lew, Tito Arana, Susan Arthur
BACKGROUND: North Carolina Nutrition and Physical Activity Self-Assessment for Child Care (NAP SACC) resources improve child body mass index (BMI) when the resources are introduced by nurses to child care providers, and offered with workshops and incentives. In San Francisco, public health and child care agencies partnered to adapt NAP SACC resources into an annual "Healthy Apple" quality improvement program (HAP). METHODS: This cluster randomized controlled trial pilot-tested integration of the HAP with bi-annual public health screenings by nurses...
December 19, 2017: BMC Public Health
https://www.readbyqxmd.com/read/29319388/woohwangcheongsimwon-prevents-high-fat-diet-induced-memory-deficits-and-induces-sirt1-in-mice
#4
Hyunwoo Park, Mia Kim, Im-Joon Shin, Jonghee Park, Soo Yong Bang, Chunsik Yi, Myoung-Ae Kim, Jae-Hwan Lew, Joo Won Suh, Sungho Maeng
Woohwangcheongsimwon (WHC) is a mixture of herbal medicines that is widely prescribed in Korean traditional medicine. SIRT1 is known for its regulatory roles in energy metabolism, oxidative stress, and circadian rhythms. This study was designed to determine whether WHC can increase and mimic the biological reactions of SIRT1 activation. Ten-month-old male mice were divided into four groups: nontreated normal diet (ND), nontreated high-fat diet (HFD), WHC-treated ND, and WHC-treated HFD. Body weight and cognitive functions were evaluated after treatment...
February 2018: Journal of Medicinal Food
https://www.readbyqxmd.com/read/29306646/characterizing-surf-zone-injuries-from-the-five-most-populated-beaches-on-the-atlantic-fronting-delaware-coast-delaware-surf-zone-injury-demographics
#5
Matthew B Doelp, Jack A Puleo, Paul Cowan, Michelle Arford-Granholm
INTRODUCTION: Beaches are a popular destination for recreation activities. Surf zone injuries (SZI) can occur resulting from a variety of in-water activities. Little is known regarding the sustained injury types, or demographics of injured persons and activities leading to injuries. METHODS: This study examines the distribution of SZI types, activities and populations occurring on Delaware Beaches as recorded by a local level III trauma center (Department of Emergency Medicine at Beebe Healthcare in Lewes, Delaware)...
December 24, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29285924/self-catalyzing-chemiluminescence-of-luminol-diazonium-ion-and-its-application-for-catalyst-free-hydrogen-peroxide-detection-and-rat-arthritis-imaging
#6
Chunxin Zhao, Hongbo Cui, Jing Duan, Shenghai Zhang, Jiagen Lv
We report the unique self-catalyzing chemiluminescence (CL) of luminol-diazonium ion (N2 + -luminol) and its analytical potential. Visual CL emission was initially observed when N2 + -luminol was subjected to alkaline aqueous H2 O2 without the aid of any catalysts. Further experimental investigations found peroxidase-like activity of N2 + -luminol on the cleavage of H2 O2 into OH• radical. Together with other experimental evidence, the CL mechanism is suggested as the activation of N2 + -luminol and its dediazotization product 3-hydroxyl luminol by OH• radical into corresponding intermediate radicals, and then further oxidation to excited-state 3-N2 + -phthalic acid and 3-hydroxyphthalic acid, which finally produce 415 nm CL...
February 6, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29164009/next-generation-gene-sequencing-differentiates-hypoplastic-myelodysplastic-syndrome-from-aplastic-anemia
#7
Jeffrey L Lew, Joshua L Fenderson, Mark G Carmichael
Hypoplastic Myelodysplastic Syndrome (h-MDS) comprises 15% of all MDS and has traditionally been difficult to distinguish from aplastic anemia (AA) by current testing. Accurate differentiation is important because treatment and prognosis differ. Since the publication of the 2008 World Health Organization classification of MDS, next-generation DNA sequencing has discovered novel mutations strongly associated with AA and MDS. Recent research supports the utility of identifying these mutations in the diagnosis and management of MDS; however, use of next-generation sequencing is not yet recommended in guidelines and the study is not routinely performed...
November 2017: Hawai'i Journal of Medicine & Public Health: a Journal of Asia Pacific Medicine & Public Health
https://www.readbyqxmd.com/read/29076316/salvage-of-infected-breast-implants
#8
Joon Ho Song, Young Seok Kim, Bok Ki Jung, Dong Won Lee, Seung Yong Song, Tai Suk Roh, Dae Hyun Lew
BACKGROUND: Implant-based breast reconstruction is being performed more frequently, and implants are associated with an increased risk of infection. We reviewed the clinical features of cases of implant infection and investigated the risk factors for breast device salvage failure. METHODS: We retrospectively analyzed 771 patients who underwent implant-based breast reconstruction between January 2010 and December 2016. Age, body mass index, chemotherapy history, radiation exposure, and smoking history were assessed as potential risk factors for postoperative infection...
November 2017: Archives of Plastic Surgery
https://www.readbyqxmd.com/read/29058098/osteomyelitis-of-the-lower-extremity-pathophysiology-imaging-and-classification-with-an-emphasis-on-diabetic-foot-infection
#9
Jacob C Mandell, Bharti Khurana, Jeremy T Smith, Gregory J Czuczman, Varand Ghazikhanian, Stacy E Smith
Osteomyelitis is inflammation of the bone caused by an infectious organism, and is a difficult clinical problem. The pathophysiology, imaging, and classification of osteomyelitis are challenging, varying with the age of the patient (child versus adult), the chronicity of the infection (acute versus chronic), and the route of spread (hematogenous versus contiguous focus), as well as the immune and vascular status of the patient and affected region. The two most common classification schemes are those of Lew and Waldvogel, and Cierny and Mader...
April 2018: Emergency Radiology
https://www.readbyqxmd.com/read/28914525/two-distinct-polymorphic-folding-states-of-self-assembly-of-the-non-amyloid-%C3%AE-component-differ-in-the-arrangement-of-the-residues
#10
Maya Pollock-Gagolashvili, Yifat Miller
Parkinson's disease is a degenerative disorder of the central nervous system. It is characterized by presence of Lewy bodies (LBs), in which the main components of the LBs are α-synuclein (AS) aggregates. The central domain of AS, known as the "non-amyloid-β component" (NAC) is responsible for the aggregation properties of AS. It is proposed that AS fibrillar structure is a well-packed cross-β structure of the NAC domains, while the N- and C-termini are disordered. Therefore, the study of the self-assembly of NAC domains is crucial in order to understand the molecular mechanisms of AS aggregation...
December 20, 2017: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/28799810/acute-effects-of-whole-body-vibration-on-balance-in-persons-with-and-without-chronic-ankle-instability
#11
RANDOMIZED CONTROLLED TRIAL
Nicole K Rendos, Hyung-Pil Jun, Nancy M Pickett, Karen Lew Feirman, Kysha Harriell, Sae Yong Lee, Joseph F Signorile
Chronic ankle instability (CAI) is a common condition following ankle injury that is associated with compromised balance. Whole body vibration training (WBVT) programmes are linked with improved balance and function in athletic and non-athletic populations and may improve balance in CAI. Twelve healthy and seven CAI participants completed two randomly assigned interventions. Two Power Plate® platforms were attached back to back using a Theraband®. Participants stood on the active plate and inactive plate for WBVT and sham interventions, respectively...
October 2017: Research in Sports Medicine
https://www.readbyqxmd.com/read/28667219/associations-between-maternal-size-and-health-outcomes-for-women-undergoing-caesarean-section-a-multicentre-prospective-observational-study-the-mum-size-study
#12
MULTICENTER STUDY
Alicia Therese Dennis, Karen Elaine Lamb, David Story, Michelle Tew, Kim Dalziel, Philip Clarke, Jospeh Lew, Anna Parker, Elizabeth Hessian, Gyln Teale, Scott Simmons, Dan Casalaz
OBJECTIVES: To investigate associations between maternal body mass index (BMI) at delivery (using pregnancy-specific BMI cut-off values 5 kg/m2 higher in each of the WHO groups) and clinical, theatre utilisation and health economic outcomes for women undergoing caesarean section (CS). DESIGN: A prospective multicentre observational study. SETTING: Seven secondary or tertiary referral obstetric hospitals. PARTICIPANTS: One thousand and four hundred and fifty-seven women undergoing all categories of CS...
June 30, 2017: BMJ Open
https://www.readbyqxmd.com/read/28574225/three-stream-bicarbonate-based-hemodialysis-solution-delivery-system-revisited-with-an-emphasis-on-some-aspects-of-acid-base-principles
#13
REVIEW
Susie Q Lew, Orly F Kohn, Yuk-Lun Cheng, Carl M Kjellstrand, Todd S Ing
Hemodialysis patients can acquire buffer base (i.e., bicarbonate and buffer base equivalents of certain organic anions) from the acid and base concentrates of a three-stream, dual-concentrate, bicarbonate-based, dialysis solution delivery machine. The differences between dialysis fluid concentrate systems containing acetic acid versus sodium diacetate in the amount of potential buffering power were reviewed. Any organic anion such as acetate, citrate, or lactate (unless when combined with hydrogen) delivered to the body has the potential of being converted to bicarbonate...
June 2017: Artificial Organs
https://www.readbyqxmd.com/read/28528130/increased-body-mass-index-is-a-risk-factor-for-end-stage-renal-disease-in-the-chinese-singapore-population
#14
Quan-Lan Jasmine Lew, Tazeen Hasan Jafar, Mohammad Talaei, Aizhen Jin, Khuan Yew Chow, Jian-Min Yuan, Woon-Puay Koh
The relationship between body mass index (BMI) and end-stage renal disease (ESRD) is confounded by co-morbidities associated with both conditions. Furthermore, the association at low range BMI is controversial. We studied this association in the Singapore Chinese Health Study, a population-based prospective cohort that recruited Singaporean Chinese men and women 45-74 years of age from 1993 to 1998. Self-reported weight, height, lifestyle factors, usual diet, and medical history were collected via an interviewer-administered questionnaire...
October 2017: Kidney International
https://www.readbyqxmd.com/read/28435430/influence-of-daily-oral-prophylactic-selenium-treatment-on-the-dibutyltin-dichloride-dbtc-induced-pancreatitis-in-rats
#15
J Merkord, N Görl, M Lemke, A Berg, H Weber, R Ramer, G Hennighausen
Dibutyltin dichloride (DBTC) is an organotin compound used as model for acute and chronic pancreatitis. Oxidative stress is one of the mechanisms of propagation of acinar cell injury in acute pancreatitis. Selenium is an essential cofactor in the antioxidant glutathione peroxidase pathway. Selenium levels are described to be subnormal in patients with acute and chronic pancreatitis. The aim of our studies was to determine the prophylactic effect of Na-selenite [5 mg kg(-1) body weight (b.w.) per os (p.o.) 7 days] on the pathogenesis and course of DBTC- induced pancreatitis...
2017: EXCLI Journal
https://www.readbyqxmd.com/read/28433992/the-aachen-minipig-phenotype-genotype-hematological-and-biochemical-characterization-and-comparison-to-the-g%C3%A3-ttingen-minipig
#16
Kerstin Pawlowsky, Lisa Ernst, Julia Steitz, Thaddäus Stopinski, Babette Kögel, Anna Henger, Reinhart Kluge, René Tolba
BACKGROUND: The pig is one of the most frequently used large animal models for biomedical research, especially in the field of translational research and surgical models. While standard livestock breeds are used in short-term and acute studies, minipig breeds are the preferred breeds in long-term and chronic studies due to their limited growth and body weight. OBJECTIVE: In consideration of the 3R principle (refinement, reduction, replacement) and the increasing demand, the aim of this study was to generate a new, robust, non-specific-pathogen-free minipig breed, the Aachen minipig...
2017: European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes
https://www.readbyqxmd.com/read/28382100/patient-satisfaction-with-implant-based-breast-reconstruction-associated-with-implant-volume-and-mastectomy-specimen-weight-ratio
#17
Woo Yeol Baek, Il Hwan Byun, Young Seok Kim, Dae Hyun Lew, Joon Jeong, Tai Suk Roh
PURPOSE: Breast volume assessment is one of the most important steps during implant-based breast reconstruction because it is critical in selecting implant size. According to previous studies, there is a close relationship between the mastectomy specimen weight and resected breast volume. The aim of this study was to evaluate long-term patient satisfaction with implant-based breast reconstruction guided by the ratio of implant volume to mastectomy specimen weight. In doing so, we describe the ideal ratio for patient satisfaction...
March 2017: Journal of Breast Cancer
https://www.readbyqxmd.com/read/28194345/transaxillary-subpectoral-placement-of-cardiac-implantable-electronic-devices-in-young-female-patients
#18
Joo Hyun Oh, Chae Min Kim, Seung Yong Song, Jae Sun Uhm, Dae Hyun Lew, Dong Won Lee
BACKGROUND: The current indications of cardiac implantable electronic devices (CIEDs) have expanded to include young patients with serious cardiac risk factors, but CIED placement has the disadvantage of involving unsightly scarring and bulging of the chest wall. A collaborative team of cardiologists and plastic surgeons developed a technique for the subpectoral placement of CIEDs in young female patients via a transaxillary approach. METHODS: From July 2012 to December 2015, subpectoral CIED placement via an axillary incision was performed in 10 young female patients, with a mean age of 25...
January 2017: Archives of Plastic Surgery
https://www.readbyqxmd.com/read/28190525/central-action-of-xenin-affects-the-expression-of-lipid-metabolism-related-genes-and-proteins-in-mouse-white-adipose-tissue
#19
Sharma Bhavya, Pei San Lew, Tooru M Mizuno
Xenin is a gastrointestinal hormone that reduces food intake when administered centrally and it has been hypothesized that central action of xenin participates in the regulation of whole-body metabolism. The present study was performed to address this hypothesis by investigating the central effect of xenin on the expression of genes and proteins that are involved in the regulation of lipid metabolism in white adipose tissue (WAT). Male obese ob/ob mice received intracerebroventricular (i.c.v.) injections of xenin (5μg) twice 12h apart...
June 2017: Neuropeptides
https://www.readbyqxmd.com/read/28153991/sex-based-differences-in-cardiometabolic-biomarkers
#20
Jeanney Lew, Monika Sanghavi, Colby R Ayers, Darren K McGuire, Torbjørn Omland, Dorothee Atzler, Maria O Gore, Ian Neeland, Jarett D Berry, Amit Khera, Anand Rohatgi, James A de Lemos
BACKGROUND: Few data are available comparing cardiovascular disease (CVD) biomarker profiles between women and men in the general population. We analyzed sex-based differences in multiple biomarkers reflecting distinct pathophysiological pathways, accounting for differences between women and men in CVD risk factors, body composition, and cardiac morphology. METHODS: A cross-sectional analysis was performed using data from the Dallas Heart Study, a multiethnic population-based study...
February 7, 2017: Circulation
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