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https://www.readbyqxmd.com/read/27858842/peroxisome-proliferator-activated-receptor-pro12ala-polymorphism-and-the-risks-of-gestational-diabetes-mellitus-an-updated-meta-analysis-of-12-studies
#1
Lihong Wang, Wenting Xu, Xu Wang
BACKGROUND: Peroxisome proliferator-activated receptors-λ (PPAR-λ) is a member of nuclear receptor superfamily and acts as a ligand-dependent transcription factor often found in the adrenal gland, the spleen, and adipose tissue. The Pro12Ala polymorphism of PPAR-λ has been associated with the risks of gestational diabetes mellitus (GDM); however, association studies have provided conflicting results. The aim of this Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) compliant meta-analysis is to reach a more up-to-date and accurate estimation of the relationship between Pro12Ala genetic polymorphisms and the risks of GDM...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27844225/characteristics-of-cigarette-smoking-without-alcohol-consumption-and-laryngeal-cancer-overall-and-time-risk-relation-a-meta-analysis-of-observational-studies
#2
Jing-Jing Zuo, Ze-Zhang Tao, Chen Chen, Zhang-Wei Hu, Ye-Xing Xu, An-Yuan Zheng, Yi Guo
Tobacco smoking was one of the risk factors for upper aerodigestive tract cancer, but exclusive quantification of the impact of cigarette smoking on laryngeal cancer had not been investigated. A meta-analysis of researches that had reported quantitative estimates of cigarette smoking and risk of laryngeal cancer by March 2016 was performed. Pooled estimates of relative risks and their 95% confidence intervals were obtained and summarized. Sensitivity analysis and subgroup analysis were implemented to find out sources of research heterogeneity and the effect of potential confounders...
November 14, 2016: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/27822541/16s-rrna-amplicon-sequencing-for-epidemiological-surveys-of-bacteria-in-wildlife
#3
Maxime Galan, Maria Razzauti, Emilie Bard, Maria Bernard, Carine Brouat, Nathalie Charbonnel, Alexandre Dehne-Garcia, Anne Loiseau, Caroline Tatard, Lucie Tamisier, Muriel Vayssier-Taussat, Helene Vignes, Jean-François Cosson
The human impact on natural habitats is increasing the complexity of human-wildlife interactions and leading to the emergence of infectious diseases worldwide. Highly successful synanthropic wildlife species, such as rodents, will undoubtedly play an increasingly important role in transmitting zoonotic diseases. We investigated the potential for recent developments in 16S rRNA amplicon sequencing to facilitate the multiplexing of the large numbers of samples needed to improve our understanding of the risk of zoonotic disease transmission posed by urban rodents in West Africa...
July 2016: MSystems
https://www.readbyqxmd.com/read/27813151/consideration-of-growth-age-related-effects-on-globe-size-and-corneal-thickness-in-ovine-eyes-for-use-in-laboratory-studies
#4
Michael J Doughty
PURPOSE: The aim was to assess differences in eyeball mass, corneal diameter and central corneal thickness in slaughterhouse-procured ovine eyes. METHODS: Over a 12-year period, measurements of eye globe mass, horizontal corneal diameter and central corneal thickness were routinely undertaken within two hours post-mortem. Only eyes free of obvious mechanical damage or disease were used. RESULTS: From measurements on 736 quality-selected and trimmed eyes, globe wet mass ranged from 10...
November 3, 2016: Clinical & Experimental Optometry: Journal of the Australian Optometrical Association
https://www.readbyqxmd.com/read/27794625/dropout-from-physical-activity-interventions-in-people-living-with-hiv-a-systematic-review-and-meta-analysis
#5
D Vancampfort, J Mugisha, J Richards, M De Hert, A R Lazzarotto, F B Schuch, M Probst, B Stubbs
Physical activity (PA) interventions have been shown to improve the health of people living with HIV (PLWH), yet treatment dropout poses an important challenge. We conducted a meta-analysis to investigate the prevalence and predictors of treatment dropout in PA interventions in PLWH. Electronic databases were searched for records up to September 2016. Randomized control trials of PA interventions in PLWH reporting dropout rates were included. Random effects meta-analysis and meta-regression analyses were employed...
October 31, 2016: AIDS Care
https://www.readbyqxmd.com/read/27747220/resin-bonding-of-self-etch-adhesives-to-bovine-dentin-bleached-from-pulp-chamber
#6
Akiko Haruyama, Atsushi Kameyama, Junji Kato, Shinji Takemoto, Yutaka Oda, Eiji Kawada, Toshiyuki Takahashi, Masahiro Furusawa
This study evaluated the microtensile bond strength (μTBS) of 1-step self-etch adhesives (1-SEAs) and 2-step self-etch adhesives (2-SEAs) to pulp chamber dentin immediately after bleaching with 2 types of common bleaching techniques. Pulp chamber dentin of bovine teeth was bleached using 30% hydrogen peroxide (H2O2) solution with quartz-tungsten-halogen light-curing unit (Group 1) and 3.5% H2O2-containing titanium dioxide (TiO2) (Pyrenees®) activated with 405-nm violet diode laser for 15 min (Group 2). Unbleached specimens were placed in distilled water for 15 min and used as controls...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27744594/labral-reattachment-in-femoroacetabular-impingement-surgery-results-in-increased-10-year-survivorship-compared-with-resection
#7
Helen Anwander, Klaus A Siebenrock, Moritz Tannast, Simon D Steppacher
BACKGROUND: Since the importance of an intact labrum for normal hip function has been shown, labral reattachment has become the standard method for open or arthroscopic treatment of hips with femoroacetabular impingement (FAI). However, no long-term clinical results exist evaluating the effect of labral reattachment. A 2-year followup comparing open surgical treatment of FAI with labral resection versus reattachment was previously performed at our clinic. The goal of this study was to report a concise followup of these patients at a minimum of 10 years...
October 15, 2016: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/27731896/predicting-inadequate-response-to-acute-migraine-medication-results-from-the-american-migraine-prevalence-and-prevention-ampp-study
#8
Richard B Lipton, Sagar Munjal, Dawn C Buse, Kristina M Fanning, Alix Bennett, Michael L Reed
BACKGROUND: Pain freedom at 2 hours and sustained pain response at 24 hours are important outcomes of acute migraine therapy. Some studies have examined rates and predictors of successful treatment outcomes for single attacks in clinical trials. However, little is known about predictors of typical response to acute treatment over multiple attacks in the population. OBJECTIVES: To identify sociodemographic features, headache characteristics, comorbidities and treatment-related factors that predict acute treatment success or failure at 2 hours and 24 hours post dose in a US population sample of persons with episodic migraine...
November 2016: Headache
https://www.readbyqxmd.com/read/27716283/patient-reported-outcomes-in-transition-from-high-dose-u-100-insulin-to-human-regular-u-500-insulin-in-severely-insulin-resistant-patients-with-type-2-diabetes-analysis-of-a-randomized-clinical-trial
#9
Samaneh Kabul, Robert C Hood, Ran Duan, Amy M DeLozier, Julie Settles
BACKGROUND: Initiation and titration of human regular U-500 insulin (U-500R) with a dosing algorithm of either thrice daily (TID) or twice daily (BID) improved glycemic control with fewer injections in patients with type 2 diabetes treated with high-dose, high-volume U-100 insulin. The objective of this analysis was to compare patient-reported outcomes between U-500R TID and BID treatment groups in this titration-to-target randomized, clinical trial. METHODS: In this 24-week, open-label, parallel trial, 325 patients were randomized to TID (n = 162) or BID (n = 163) U-500R after a 4-week lead-in period (screening)...
September 30, 2016: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/27600024/association-between-abcb1-polymorphisms-and-haplotypes-and-alzheimer-s-disease-a-meta-analysis
#10
Xin Zhong, Ming-Yan Liu, Xiao-Hong Sun, Min-Jie Wei
Although several epidemiological studies have investigated the association between ATP-binding cassette subfamily B member 1 (ABCB1) gene polymorphisms and Alzheimer's disease (AD) susceptibility, controversial results exist. Here, we performed a meta-analysis to assess whether ABCB1 polymorphisms 3435C > T (rs1045642), 2677G > T/A (rs2032582), 1236C > T (rs1128503) and haplotypes were associated with AD risk. Nine independent publications were included and analyzed. Crude odds ratio (OR) and 95% confidence interval (CI) were applied to investigate the strength of the association...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27569181/regional-specific-modulation-of-neuronal-activation-associated-with-nitric-oxide-synthase-inhibitors-in-an-animal-model-of-antidepressant-activity
#11
Eoin Sherwin, Valentina Gigliucci, Andrew Harkin
OBJECTIVE: The regional specific modulation of neuronal activation following drug administration is of interest to determine brain areas involved in the behavioural effects of experimental test compounds. In the current investigation the effects of the L-arginine related NOS inhibitor N(ω)-l-nitroarginine (L-NA) and the structurally unrelated selective neuronal NOS inhibitor 1-(2-Trifluoro-methyl-phenyl) imidazole (TRIM) were assessed in the rat for changes in regional c-FOS immunoreactivity, a marker of neuronal activation, upon exposure to the forced swimming test (FST)...
January 1, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/27521591/transcriptome-signatures-in-common-carp-spleen-in-response-to-aeromonas-hydrophila-infection
#12
Yanliang Jiang, Shuaisheng Feng, Songhao Zhang, Hong Liu, Jianxin Feng, Xidong Mu, Xiaowen Sun, Peng Xu
The common carp is an important aquaculture species that is worldwide distributed. Nowadays, intensive rearing in aquaculture increases the susceptibility of fish to various pathogens such as Aeromonas hydrophila, which has caused severe damage to carp production. However, systematic analysis on the host response of common carp against A. hydrophila is less studied. In order to better understand the common carp immune response process against bacteria at the global gene expression level, we examined transcriptional profiles of the common carp spleen at three timepoints following experimental infection with A...
October 2016: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/27431730/use-of-vine-trimming-wastes-as-carrier-for-amycolatopsis-sp-to-produce-vanillin-vanillyl-alcohol-and-vanillic-acid
#13
Juan Francisco Castañón-Rodríguez, Noelia Pérez-Rodríguez, Ricardo Pinheiro de Souza Oliveira, María Guadalupe Aguilar-Uscanga, José Manuel Domínguez
Raw vine-trimming wastes or the solid residues obtained after different fractionation treatments were evaluated for their suitability as Amycolatopsis sp. immobilization carriers during the bioconversion of ferulic acid into valuable phenolic compounds such as vanillin, vanillyl alcohol, and vanillic acid, the main flavor components of vanilla pods. Previously, physical-chemical characteristics of the materials were determined by quantitative acid hydrolysis and water absorption index (WAI), and microbiological characteristics by calculating the cell retention in the carrier (λ)...
October 2016: Current Microbiology
https://www.readbyqxmd.com/read/27419245/effect-of-dentin-pretreatment-on-bond-strength-stability-of-self-etching-and-etch-and-rinse-adhesives-to-intracoronally-bleached-dentin
#14
Ilzes Marianne Borges de Souza, Camila Silva Araújo, Carlos José Soares, André Luis Faria-E-Silva
PURPOSE: To evaluate the effect of chlorhexidine or glutaraldehyde pretreatment on the bonding stability of selfetching and etch-and-rinse adhesives to bleached dentin. MATERIALS AND METHODS: The occlusal surface of 80 third molars was abraded to expose a flat mid-dentin surface, which was then subjected to a bleaching procedure using 20% hydrogen peroxide and sodium perborate for 14 days. Afterwards, the specimens were kept in distilled water, followed by application of either a three-step etchand- rinse (Adper Scotchbond Multi-Purpose Plus, SBMP) or a two-step self-etching (Clearfil SE Bond, CSE) adhesive system...
2016: Journal of Adhesive Dentistry
https://www.readbyqxmd.com/read/27344388/short-communication-pilot-study-on-hormonal-metabolic-and-behavioral-stress-response-to-treatment-of-claw-horn-lesions-in-acutely-lame-dairy-cows
#15
S Janßen, C Wunderlich, M Heppelmann, R Palme, A Starke, W Kehler, A Steiner, A Rizk, U Meyer, S Daenicke, J Rehage
Short-term effects of therapeutic claw trimming in acutely lame cows (n=21) with nonadvanced claw horn lesions on the endocrine, metabolic, and behavioral stress responses were investigated in comparison to regular claw trimming in nonlame control cows (n=21). Controls were matched to lame cows by parity and stage of lactation. Lame cows suffering from typical sole ulcers or white line disease were blinded and randomly assigned to 2 treatments, receiving 15 min before interventions either ketoprofen (n=11; 3mg/kg of BW intramuscularly; Romefen, Merial, Lyon, France) or placebo (n=10; saline in equivalent amount and route of administration)...
September 2016: Journal of Dairy Science
https://www.readbyqxmd.com/read/27310960/prognostic-role-of-platelet-lymphocyte-ratio-in-colorectal-cancer-a-systematic-review-and-meta-analysis
#16
Dewen Tan, Yan Fu, Qi Su, Heling Wang
Many studies have been reported that platelet-lymphocyte ratio (PLR) may be associated with the prognosis of colorectal cancer (CRC), but the results are inconsistent. Current opinion on the prognostic role of the PLR in CRC is inconsistent and inconclusive. Therefore, we conduct a meta-analysis that combines these studies and to identify the prognostic value of PLR in patients with CRC. Data were retrieved from PubMed, EMBASE, Cochrane Library, and Web of Science databases that came from inception through January 2016...
June 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27297839/validation-of-the-ansr-%C3%A2-e-coli-o157-h7-method-for-detection-of-e-coli-o157-h7
#17
Ryan Viator, Susan Alles, Quynh-Nhi Le, Edan Hosking, Evan Meister, Lisa Pinkava, Eric Tovar, Mark Mozola, Jennifer Rice
A performance validation of the ANSR(®) for E. coli O157:H7 method was conducted in selected food matrixes. This assay uses selective nicking enzyme amplification technology to amplify target genes. Samples are enriched for 12-24 h and then lysed. The assay is completed within 40 min using real-time detection in a combination incubator/fluorescence detector and software. When 44 distinct strains of Escherichia coli O157:H7 and 6 strains of E. coli O157:NM were tested for inclusivity, all 50 strains produced positive results...
May 2016: Journal of AOAC International
https://www.readbyqxmd.com/read/27200180/dry-aging-of-beef-review
#18
REVIEW
Dashmaa Dashdorj, Vinay Kumar Tripathi, Soohyun Cho, Younghoon Kim, Inho Hwang
The present review has mainly focused on the specific parameters including aging (aging days, temperature, relative humidity, and air flow), eating quality (flavor, tenderness and juiciness), microbiological quality and economic (shrinkage, retail yields and cost) involved beef dry aging process. Dry aging is the process where beef carcasses or primal cuts are hanged and aged for 28 to 55 d under controlling environment conditions in a refrigerated room with 0° to 4 °C and with relative humidity of 75 to 80 %...
2016: Journal of Animal Science and Technology
https://www.readbyqxmd.com/read/27097933/case-control-study-of-nutritional-and-environmental-factors-and-the-risk-of-oral-clefts-in-thailand
#19
Christy M McKinney, Araya Pisek, Bowornsilp Chowchuen, Timothy DeRouen, Benja Muktabhant, Suteera Pradubwong, Cathy Yeung, Waranuch Pitiphat
BACKGROUND: One infant in 700 is born with an oral cleft. Prior studies suggest low micronutrient status is associated with an increased risk of oral clefts. Environmental factors such as passive smoke exposure or supplement use may also affect oral cleft risk. We examined nutrition and environmental related risk factors for oral clefts. METHODS: We conducted a case-control study in Northeast Thailand in 2012 to 2013. We enrolled 95 cases and 95 controls. We recruited cases with a nonsyndromic cleft lip with or without a cleft palate (CL±P) less than 24 months old...
July 2016: Birth Defects Research. Part A, Clinical and Molecular Teratology
https://www.readbyqxmd.com/read/27075660/validation-of-the-ansr-sup-%C3%A2-sup-em-e-coli-em-o157-h7-method-for-detection-of-em-e-coli-em-o157-h7
#20
(no author information available yet)
A performance validation of the ANSR(®) for E. coli O157:H7 method was conducted in selected food matrixes. This assay uses selective nicking enzyme amplification technology to amplify target genes. Samples are enriched for 12-24 h and then lysed. The assay is completed within 40 min using real-time detection in a combination incubator/fluorescence detector and software. When 44 distinct strains of Escherichia coli O157:H7 and 6 strains of E. coli O157:NM were tested for inclusivity, all 50 strains produced positive results...
March 31, 2016: Journal of AOAC International
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