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https://www.readbyqxmd.com/read/28977524/regional-specific-modulation-of-stress-induced-neuronal-activation-associated-with-the-psd95-nos-interaction-inhibitor-zl006-in-the-wistar-kyoto-rat
#1
Eoin Sherwin, Aifric Lennon, Andrew Harkin
Background: To determine brain areas involved in the antidepressant-related behavioral effects of the selective neuronal nitric oxide synthase inhibitor 1-(2-Trifluoro-methyl-phenyl) imidazole (TRIM) and experimental test compound 4-((3,5-dichloro-2-hydroxybenzyl)amino)-2-hydroxybenzoic acid (ZL006), an inhibitor of the PSD of 95 kDa/neuronal nitric oxide synthase interaction in the N-methyl-D-aspartic acid receptor signalling pathway, regional specific expression of the neuronal activation marker c-FOS was assessed following exposure to the forced swimming test in the Wistar Kyoto rat...
October 1, 2017: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28968135/comparison-of-clinical-and-radiographic-outcomes-between-central-and-lateral-lesions-after-osteochondral-autograft-transplantation-for-osteochondritis-dissecans-of-the-humeral-capitellum
#2
Takeshi Matsuura, Yusuke Hashimoto, Kazuya Nishino, Yohei Nishida, Shinji Takahashi, Nagakazu Shimada
BACKGROUND: Clinical studies have reported satisfactory results after osteochondral autograft transplantation (OAT) for central lesions of unstable osteochondritis dissecans (OCD) of the elbow. However, the outcomes after OAT for lateral lesions remain unclear. HYPOTHESIS: The clinical outcomes of OAT would be better for central lesions than for lateral lesions. STUDY DESIGN: Cohort study; Level of evidence, 3. METHODS: The authors retrospectively evaluated 103 juvenile athletes (mean age, 13...
September 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28933219/suppression-of-trim32-enhances-motor-function-repair-after-traumatic-brain-injury-associated-with-antiapoptosis
#3
Zi-Bin Zhang, Liu-Lin Xiong, Bin-Tuan Lu, Hui-Xiang Zhang, Piao Zhang, Ting-Hua Wang
To investigate the role of Trim32 in traumatic brain injury (TBI), adult male Sprague Dawley (SD) rats and mice were randomly divided into sham (n = 6) and TBI groups ( n = 24), respectively. Then, mice were assigned into Trim32 knockout mice (Trim32-KO [+/-]) and wild-type (WT) littermates. The TBI model used was the Feeney free-falling model, and neurological function was evaluated after TBI using a neurological severity score (NSS). Reverse transcription polymerase chain reaction (RT-PCR), Western blot, and immunohistochemistry were used to investigate the expression of Trim32 in the damaged cortex...
July 2017: Cell Transplantation
https://www.readbyqxmd.com/read/28916426/prognostic-relevance-of-tripartite-motif-containing-24-expression-in-colorectal-cancer
#4
Feng-Qin Wang, Yan Han, WenJuan Yao, Jing Yu
Colorectal cancer is one of the most frequent malignancies in the world. Tripartite motif containing 24 (TRIM24) is a member of the TRIM protein family and a coregulator for multiple nuclear receptors. Altered expression of TRIM24 has been shown in a spectrum of human cancers. However, the clinical role of TRIM24 in colorectal cancer remains unknown. Here, gene expression data in colorectal cancer and normal tissues were downloaded from Gene Expression Omnibus (GEO). Western blotting analysis was conducted to compare TRIM24 expression between colorectal cancer and non-cancerous tissues...
October 2017: Pathology, Research and Practice
https://www.readbyqxmd.com/read/28803007/associations-between-biosecurity-practices-and-bovine-digital-dermatitis-in-danish-dairy-herds
#5
Victor H S Oliveira, Jan T Sørensen, Peter T Thomsen
The relationship between biosecurity and digital dermatitis (DD) was evaluated in 8,269 cows from a convenience sample of 39 freestall dairy herds. The hypothesis was that poor implementation of biosecurity was associated with higher within-herd prevalence of DD. All lactating cows were scored as negative or positive for DD at the hind legs during milking in the milking parlor. Information about biosecurity was obtained through questionnaires addressed to farmers, on-farm observations, and information from the Danish Cattle Database (www...
August 9, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28759846/the-association-of-folate-and-depression-a-meta-analysis
#6
REVIEW
Ansley Bender, Kelsey E Hagan, Neal Kingston
BACKGROUND: Previous research suggested that folate levels play an important role in the etiology and course of depression. However, the literature has been inconsistent with regard to differences in folate level between individuals with and without depression. The present meta-analysis synthesized the results of previous studies to examine whether individuals with depression had lower levels of folate than individuals without depression. METHODS: Meta-analytic procedures were conducted in accordance with PRISMA guidelines...
December 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28732120/the-prevalence-of-molar-incisor-hypomineralization-evidence-from-70-studies
#7
Dongdong Zhao, Bao Dong, Dandan Yu, Qiongqiong Ren, Yehuan Sun
OBJECTIVE: A growing number of studies have investigated the prevalence of Molar Incisor Hypomineralization (MIH) around the world. The aim of this study was to systematically estimate the pooled prevalence of MIH. METHODS: A comprehensive literature research was completed in English and Chinese databases. Random effect models were used to calculate the pooled prevalence. To address the heterogeneity, meta-regression, and sensitivity analyzes were conducted. Publication bias was estimated by trim and fill method...
July 21, 2017: International Journal of Paediatric Dentistry
https://www.readbyqxmd.com/read/28692844/comparative-bonding-ability-to-dentin-of-a-universal-adhesive-system-and-monomer-conversion-as-functions-of-extended-light-curing-times-and-storage
#8
Paula Costa Pinheiro Sampaio, Paula de Castro Kruly, Clara Cabral Ribeiro, Leandro Augusto Hilgert, Patrícia Nóbrega Rodrigues Pereira, Polliana Mendes Candia Scaffa, Vinicius Di Hipólito, Paulo Henrique Perlatti D'Alpino, Fernanda Cristina Pimentel Garcia
OBJECTIVES: The purpose of this in vitro study was to evaluate the bonding ability and monomer conversion of a universal adhesive system applied to dentin as functions of different curing times and storage. The results were compared among a variety of commercial adhesives. MATERIALS AND METHODS: Flat superficial dentin surfaces were exposed on human molars and assigned into one of the following adhesives (n = 15): total-etch Adper Single Bond 2 (SB) and Optibond Solo Plus (OS), self-etch Optibond All in One (OA) and Clearfil SE Bond (CSE), and Scotchbond Universal Adhesive in self-etch mode (SU)...
June 27, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28627315/bioabsorbable-fixation-screw-for-proximal-interphalangeal-arthrodesis-of-lesser-toe-deformities
#9
Jascha Armin Wendelstein, Peter Goger, Peter Bock, Reinhard Schuh, Priv Doz, Hans-Jörg Trnka
BACKGROUND: Although standard fixation of proximal interphalangeal (PIP) arthrodesis by K-wire is relatively inexpensive and well established, it does have some drawbacks, making newer fixation devices interesting. The aim of this study was to clinically and radiologically assess the operative correction of the lesser toe deformation in the form of a PIP arthrodesis using a bioabsorbable 2.7-mm fixation screw. METHODS: From January 2011 until October 2013, 34 patients underwent a PIP arthrodesis using the TRIM-IT (Arthrex) 2...
June 1, 2017: Foot & Ankle International
https://www.readbyqxmd.com/read/28611503/exploiting-phosphate-starved-cells-of-scenedesmus-sp-for-the-treatment-of-raw-sewage
#10
Swati Yewalkar-Kulkarni, Gayatri Gera, Sanjay Nene, Kiran Pandare, Bhaskar Kulkarni, Sanjay Kamble
Phosphate depletion is one of the favorable ways to enhance the sewage water treatment with the algae, however, detailed information is essential with respect to internal phosphate concentration and physiology of the algae. The growth rate of the phosphate-starved Scenedesmus cells was reduced drastically after 48 h. Indicating cells entered in the stationary phase of the growth cycle. Fourier Transform Infrared analysis of phosphate-starved Scenedesmus cells showed the reduction in internal phosphate concentration and an increase in carbohydrate/phosphate and carbohydrate/lipid ratio...
June 2017: Indian Journal of Microbiology
https://www.readbyqxmd.com/read/28592235/gene-centromere-mapping-in-meiotic-gynogenetic-european-seabass
#11
Münevver Oral, Julie Colléter, Michaël Bekaert, John B Taggart, Christos Palaiokostas, Brendan J McAndrew, Marc Vandeputte, Béatrice Chatain, Heiner Kuhl, Richard Reinhardt, Stefano Peruzzi, David J Penman
BACKGROUND: Fully isogenic lines in fish can be developed using "mitotic" gynogenesis (suppression of first zygotic mitosis following inactivation of the sperm genome). However, genome-wide verification of the steps in this process has seldom been applied. We used ddRADseq to generate SNP markers in a meiotic gynogenetic family of European seabass (Dicentrarchus labrax): (i) to verify the lack of paternal contribution in a meiotic gynogenetic family; (ii) to generate a gene-centromere map from this family; (iii) to identify telomeric markers that could distinguish mitotic gynogenetics from meiotic gynogenetics, which sometimes arise spontaneously in mitotic gynogenetic families...
June 7, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28465353/trim24-protein-promotes-and-trim32-protein-inhibits-cardiomyocyte-hypertrophy-via-regulation-of-dysbindin-protein-levels
#12
COMPARATIVE STUDY
Ankush Borlepawar, Ashraf Yusuf Rangrez, Alexander Bernt, Lynn Christen, Samuel Sossalla, Derk Frank, Norbert Frey
We have previously shown that dysbindin is a potent inducer of cardiomyocyte hypertrophy via activation of Rho-dependent serum-response factor (SRF) signaling. We have now performed a yeast two-hybrid screen using dysbindin as bait against a cardiac cDNA library to identify the cardiac dysbindin interactome. Among several putative binding proteins, we identified tripartite motif-containing protein 24 (TRIM24) and confirmed this interaction by co-immunoprecipitation and co-immunostaining. Another tripartite motif (TRIM) family protein, TRIM32, has been reported earlier as an E3 ubiquitin ligase for dysbindin in skeletal muscle...
June 16, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28461211/analysis-of-the-expression-patterns-of-the-novel-large-multigene-trim-gene-family-fintrim-in-zebrafish
#13
Kai Luo, Youshen Li, Lihai Xia, Wei Hu, Weihua Gao, Liwei Guo, Guangming Tian, Zhitao Qi, Hanwen Yuan, Qiaoqing Xu
Tripartite motif (TRIM) proteins are receiving increased research interest because of their roles in a wide range of cellular biological processes in innate immunity. In zebrafish (Danio rerio), the functions of the finTRIM (ftr) family are unclear. In the present study, we investigated the expression pattern of ftr12, ftr51, ftr67, ftr82, ftr83, and ftr84 in zebrafish for the first time. The results showed that ftr12, ftr67, and ftr84 are maternally expressed in the oocyte and highly expressed at the early stage (0-4 hpf) of embryo (P < 0...
April 28, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28460750/cross-sectional-study-of-the-prevalence-of-and-risk-factors-for-hoof-disorders-in-horses-in-the-netherlands
#14
M Holzhauer, R Bremer, I Santman-Berends, O Smink, I Janssens, W Back
Information is scarce on the prevalence of hoof disorders in horses. In this study, we examined the prevalence of and risk factors for hoof disorders in a population of horses in The Netherlands. In a group of 942 randomly selected horses, hoof health was scored during regular foot trimming (one horse/farm). Hooves were assessed for the occurrence of one of 12 hoof disorders by a group of 21 certified farriers in two periods i.e. winter and summer of 2015. The mean age of the group of horses was 11.2±5.6years...
May 1, 2017: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/28404961/increased-platelet-lymphocyte-ratio-closely-relates-to-inferior-clinical-features-and-worse-long-term-survival-in-both-resected-and-metastatic-colorectal-cancer-an-updated-systematic-review-and-meta-analysis-of-24-studies
#15
REVIEW
Nan Chen, Wanling Li, Kexin Huang, Wenhao Yang, Lin Huang, Tianxin Cong, Qingfang Li, Meng Qiu
Colorectal cancer (CRC) is one of the most common cancers worldwide. However, the prognostic and clinical value of platelet-lymphocyte ratio (PLR) in colorectal cancer was still unclear, which attracted more and more researchers' considerable attention. We performed a systematic review and meta-analysis to investigate the relationship between PLR and survival as well as clinical features of CRC update to September 2016. The hazard ratio (HR) or odds ratio (OR) with 95% confidence interval (CI) were calculated to access the association...
May 9, 2017: Oncotarget
https://www.readbyqxmd.com/read/28380524/fabrication-yields-of-serially-harvested-calf-fed-holstein-steers-fed-zilpaterol-hydrochloride
#16
N D May, T J McEvers, L J Walter, J A Reed, J P Hutcheson, T E Lawrence
Holstein steers ( = 110) were fed zilpaterol hydrochloride (ZH) for 0 or 20 d before slaughter during a 280-d serial harvest study. Cattle were harvested every 28 d beginning at 254 d on feed (DOF) and concluding at 534 DOF. After slaughter, carcasses were chilled for 48 h and then fabricated into boneless closely trimmed or denuded subprimals, lean trim, trimmable fat, and bone. Inclusion of ZH increased cold side weight (CSW) by 10.3 kg ( < 0.01; 212.7 vs. 202.4 kg [SEM 1.96]) and saleable yield by 10...
March 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/28222156/toothbrush-abrasivity-in-a-long-term-simulation-on-human-dentin-depends-on-brushing-mode-and-bristle-arrangement
#17
Mozhgan Bizhang, Ilka Schmidt, Yong-Hee Patricia Chun, Wolfgang H Arnold, Stefan Zimmer
OBJECTIVE: The aim of this study was to evaluate the susceptibility of dentin to brushing abrasion using four different toothbrushes (rotating-oscillating, sonic and two types of manual toothbrushes) with the same brushing forces. METHODS: Dentin samples (n = 72) were selected from 72 impacted third molars. Half of the surface of dentin samples was covered with an adhesive tape, creating a protected and a freely exposed area in the same specimen. Brushing was performed with either a: sonic (Sonicare PowerUp, Philips GmbH, Hamburg, Germany), b: oscillating-rotating (Oral B Vitality Precisions Clean, Procter & Gamble, Schwalbach am Taunus, Germany) or two different manual toothbrushes c: flat trim brush head toothbrush (Dr...
2017: PloS One
https://www.readbyqxmd.com/read/28190486/randomised-controlled-trial-to-evaluate-the-effect-of-foot-trimming-before-and-after-first-calving-on-subsequent-lameness-episodes-and-productivity-in-dairy-heifers
#18
RANDOMIZED CONTROLLED TRIAL
S A Mahendran, J N Huxley, Y-M Chang, M Burnell, D C Barrett, H R Whay, T Blackmore, C S Mason, N J Bell
The objective of this study was to assess both independent and combined effects of routine foot trimming of heifers at 3 weeks pre-calving and 100 days post calving on the first lactation lameness and lactation productivity. A total of 419 pre-calving dairy heifers were recruited from one heifer rearing operation over a 10-month period. Heifers were randomly allocated into one of four foot trimming regimens; pre-calving foot trim and post-calving lameness score (Group TL), pre-calving lameness score and post-calving foot trim (Group LT), pre-calving foot trim and post-calving foot trim (Group TT), and pre-calving lameness score and post-calving lameness score (Group LL, control group)...
February 2017: Veterinary Journal
https://www.readbyqxmd.com/read/28187368/outcomes-of-autograft-alone-versus-peek-autograft-interbody-fusion-in-the-treatment-of-adult-lumbar-isthmic-spondylolisthesis
#19
Gang Wang, Dunfu Han, Zhenglin Cao, Honggang Guan, Tianhang Xuan
OBJECTIVES: Bone resulting from a complete resection of the posterior arch can be cut into an autograft bone that contains the facet joint structure and morselised bone for interbody fusion. However, whether a strut autograft that contains this trimmed facet joint can produce the same clinical and radiographic outcomes as a cage for interbody fusion remains unclear. The aim of this study was to compare the outcomes of a local facet joint autograft alone to those of polyetheretherketone (PEEK)+autograft for posterior lumbar interbody fusion (PLIF) in the treatment of adult isthmic spondylolisthesis...
April 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/28104502/staying-away-from-the-optic-nerve-a-formula-for-modifying-glaucoma-drainage-device-surgery-in-pediatric-and-other-small-eyes
#20
Milica A Margeta, Anthony N Kuo, Alan D Proia, Sharon F Freedman
PURPOSE: To provide guidelines for safe implantation of glaucoma drainage devices (GDDs) in small and pediatric eyes to avoid contact between the optic nerve (ON) and the posterior edge of the GDD plate. METHODS: We developed a formula for calculating limbus-to-ON distance to estimate the available "real estate" for GDD placement in small eyes. The formula was validated using eyes of pediatric decedents undergoing clinical autopsy, with axial lengths (AL) of 15-24 mm...
February 2017: Journal of AAPOS: the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus
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