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https://www.readbyqxmd.com/read/29462021/review-of-endovenous-thermal-ablation-of-the-great-saphenous-vein-endovenous-laser-therapy-versus-radiofrequency-ablation
#1
Omeed Ahadiat, Shauna Higgins, Alexandre Ly, Azadeh Nazemi, Ashley Wysong
BACKGROUND: Endovenous thermal ablation is a popular treatment for varicose veins of the greater saphenous vein. Two common techniques of thermal ablation are endovenous laser therapy (EVLT) and radiofrequency ablation (RFA). OBJECTIVE: The authors compare EVLT and RFA in vein therapy. METHODS: A review was conducted using PubMed. Studies comparing the treatment modalities were gathered and compared on the basis of 5 main standpoints, including: efficacy, side effects, serious complications, recurrence, and quality of life...
February 15, 2018: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/29455391/focal-ischaemic-infarcts-expand-faster-in-cerebellar-cortex-than-cerebral-cortex-in-a-mouse-photothrombotic-stroke-model
#2
Nagarajesh Gorlamandala, Jasneet Parmar, Amanda J Craig, John M Power, Andrew J Moorhouse, Arun V Krishnan, Gary D Housley
It is generally accepted that the cerebellum is particularly vulnerable to ischaemic injury, and this may contribute to the high mortality arising from posterior circulation strokes. However, this has not been systematically examined in an animal model. This study compared the development and resolution of matched photothrombotic microvascular infarcts in the cerebellar and cerebral cortices in adult 129/SvEv mice of both sexes. The photothrombotic lesions were made using tail vein injection of Rose Bengal with a 532 nm laser projected onto a 2 mm diameter aperture over the target region of the brain (with skull thinning)...
February 17, 2018: Translational Stroke Research
https://www.readbyqxmd.com/read/29455013/laser-recanalization-of-central-venous-occlusion-to-salvage-a-threated-arteriovenous-fistula
#3
Sagar Rambhia, Matthew Janko, Robert I Hacker
Central venous occlusion is conventionally managed with balloon angioplasty, stent extension or sharp recanalization. Here we describe recanalization of a chronically occluded innominate vein using excimer laser after conventional techniques were unsuccessful. Patient clinical improvement and fistula patency have been sustained two years post-intervention. This technique may provide new hemodialysis access options for patients who would not otherwise be candidates for hemodialysis access on the ipsilateral side of a central venous occlusion...
February 15, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29448895/the-outcome-of-anticoagulation-on-endovenous-laser-therapy-for-superficial-venous-incompetence
#4
Jamie Vatish, Nusrat Iqbal, Viswa Retnasingam Rajalingam, Alok Tiwari
OBJECTIVES: The purpose of this study was to evaluate whether anticoagulation (warfarin or direct oral inhibitors) affected the success of endovenous treatment. METHODS: Patients taking anticoagulation (warfarin or direct oral inhibitors) undergoing endovenous treatment in the form of endovenous laser ablation (EVLA) were matched against controls for sex, age, leg, and vein. Data were collected prospectively between January 2012 and March 2017. The primary endpoint was failure of treatment at 6-week postoperative duplex scan...
January 1, 2018: Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/29448042/quantitative-comparisons-between-optical-coherence-tomography-angiography-and-matched-histology-in-the-human-eye
#5
Dong An, Chandrakumar Balaratnasingam, Morgan Heisler, Ashley Francke, MyeongJin Ju, Ian L McAllister, Marinko Sarunic, Dao-Yi Yu
The aim was to quantitatively compare retinal vascular detail as seen on optical coherence tomography angiography (OCTA) and matched histology in the human eye. 13 normal human donor eyes were used. The central retinal artery was cannulated after which human packed red blood cells were perfused through the retinal vasculature. Retinal vessels were imaged using a custom-built OCTA device during red blood cell perfusion. The eye was subsequently perfused with endothelial cell antibodies and the flat-mounted retina studied histologically using a confocal scanning laser microscope...
February 12, 2018: Experimental Eye Research
https://www.readbyqxmd.com/read/29436052/a-randomized-trial-to-compare-the-acute-reconnection-after-pulmonary-vein-isolation-with-laser-balloon-vs-radiofrequency-ablation-ratisbona-trial
#6
Ekrem Ücer, Yvette Janeczko, Joachim Seegers, Sabine Fredersdorf, Selina Friemel, Florian Poschenrieder, Lars Siegfried Maier, Carsten Gerald Jungbauer
INTRODUCTION: Dormant conduction and acute reconnection in the pulmonary veins (PV) during a PV isolation can be detected by performing an adenosine provocation test (APT). Visually guided laser balloon ablation (VGLB) creates deep transmural lesions, thus causing less acute reconnection. This study compared the acute PV reconnection rate after isolation with VGLB or with RF using an APT. METHODS AND RESULTS: Patients with paroxysmal AF were randomized to PVI with the VGLB or RF ablation...
February 13, 2018: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/29434872/regulator-of-g-protein-signaling-5-enhances-portal-vein-invasion-in-hepatocellular-carcinoma
#7
Yumi Umeno, Sachiko Ogasawara, Jun Akiba, Satoshi Hattori, Hironori Kusano, Osamu Nakashima, Hironori Koga, Takuji Torimura, Ryoji Yamakawa, Hirohisa Yano
Portal vein invasion (PVI) is a major prognostic factor in hepatocellular carcinoma (HCC). The aim of the present study was to identify molecules that regulate PVI. Sections of cancerous tissue, paired noncancerous tissue and the PVI area were collected from 3 frozen HCC sections, using laser microdissection. The present study focused on 3 upregulated molecules, integrin β3 (ITGB3), secreted phosphoprotein 1 (SPP1) and regulator of G-protein signaling 5 (RGS5), and 2 molecules that were downregulated in PVI tissue compared with cancer tissue, metallothionein 1G (MT1G) and metallothionein 1H (MT1H), as determined by cDNA microarray analysis...
February 2018: Oncology Letters
https://www.readbyqxmd.com/read/29434428/evaluation-of-endovenous-laser-ablation-for-varicose-veins-using-a-computer-simulation-model-secondary-publication
#8
REVIEW
Hisanao Hazama, Masato Yoshimori, Norihiro Honda, Kunio Awazu
Background and aims: Endovenous laser ablation (EVLA) has been well-reported as a minimally invasive method to deal with varices of the lower extremities. The lasers used fall into two categories: pigment, i.e., hemoglobin-specific lasers in the visible and near-infrared (near-IR) wavebands and longer wavelength mid-infrared lasers where the chromophore is water. The fiber used to deliver the laser energy is also important, and not enough attention has been paid to this element of EVLA...
December 31, 2017: Laser Therapy
https://www.readbyqxmd.com/read/29428734/co-transplantation-of-exosomes-derived-from-hypoxia-preconditioned-adipose-mesenchymal-stem-cells-promotes-neovascularization-and-graft-survival-in-fat-grafting
#9
Yu-di Han, Yun Bai, Xin-Long Yan, Jing Ren, Quan Zeng, Xiao-Dong Li, Xue-Tao Pei, Yan Han
BACKGROUND: Adipose-derived stromal cells (ADSCs)-derived exosomes (ADSC-Exos) account for the proangiogenic potential of stem cell. This study aimed to investigate the effect of ADSC-derived exosomes (ADSC-Exos) on the survival in fat grafting. METHODS: A nude mouse model of subcutaneous fat grafting was adopted. Hypoxic preconditioned ADSC-Exos and ADSC-Exos were injected around the grafted tissue. The fat graft sample was weighed and examined by hematoxylin and eosin (H&E) staining and immunohistochemistry...
February 8, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29421546/one-pot-synthesis-of-albumin-gadolinium-stabilized-polypyrrole-nanotheranostic-agent-for-magnetic-resonance-imaging-guided-photothermal-therapy
#10
Zhe Yang, Wenshan He, Hongyi Zheng, Jielin Wei, Pei Liu, Wei Zhu, Leping Lin, Li Zhang, Changfeng Yi, Zushun Xu, Jinghua Ren
Theranostic agents with perfect properties are needed urgently for the development of imaging guided photothermal therapy (PTT). In this work, Gd-integrated polypyrrole nanotheranostic agent (PPy@BSA-Gd) was successfully built through selecting bovine serum albumin (BSA) as both stabilizers for polymerization and biomimetic mineralization in "one pot". The obtained PPy@BSA-Gd possessed high stability and excellent photothermal property. Besides, relevant cellular assays indicated that PPy@BSA-Gd had fantastic cytocompatibility which could be further internalized by cancer cells...
January 19, 2018: Biomaterials
https://www.readbyqxmd.com/read/29421005/systematic-review-and-meta-analysis-of-endovascular-and-surgical-revascularization-for-patients-with-chronic-lower-extremity-venous-insufficiency-and-varicose-veins
#11
Sreekanth Vemulapalli, Kishan Parikh, Remy Coeytaux, Victor Hasselblad, Amanda McBroom, Abigail Johnston, Giselle Raitz, Matthew J Crowley, Kathryn R Lallinger, W Schuyler Jones, Gillian D Sanders
BACKGROUND: Chronic lower extremity venous disease (LECVD) is twice as prevalent as coronary heart disease, and invasive therapies to treat LECVD accounted for an estimated $290 million in Medicare expenditures in 2015. Despite increasing use of these invasive therapies, their comparative effectiveness is unknown. METHODS: We conducted a systematic review and meta-analysis of treatments for patients (symptomatic and asymptomatic) with lower extremity varicosities and/or lower extremity chronic venous insufficiency/incompetence/reflux...
February 2018: American Heart Journal
https://www.readbyqxmd.com/read/29412185/day-surgery-versus-outpatient-setting-for-endovenous-laser-ablation-treatment-a-prospective-cohort-study
#12
Gianfranco Varetto, Lorenzo Gibello, Edoardo Frola, Alessandra Trevisan, Andrea Trucco, Luigi Contessa, Pietro Rispoli
OBJECTIVES: The traditional surgical approach to the treatment of the superficial venous insufficiency requires at least 12 h of post-operative monitoring and this often means the necessity of an overnight hospitalization. The introduction of new, less invasive techniques (i.e endovenous laser ablation) reduces the hospitalization stay in a Day Surgery setting. However, the increasing skills of the operators and the patient's selection, allows to propose endovenous laser ablation in an Outpatient setting...
February 2, 2018: International Journal of Surgery
https://www.readbyqxmd.com/read/29409702/telangiectatic-matting-is-associated-with-hypersensitivity-and-a-bleeding-tendency
#13
Pooja Kadam, Jerrick Lim, Ian Paver, David E Connor, Kurosh Parsi
OBJECTIVE: The aim was to investigate the pathogenesis of telangiectatic matting (TM) and identify possible risk factors. METHODS: This study had two parts. The clinical records of consecutive patients were retrospectively analysed to identify risk factors for TM. In the second part, the haemostatic and coagulation profile of the subset of patients with TM were analysed and compared with controls using standard coagulation tests, platelet function and a global assay of coagulation (rotational thromboelastometry, ROTEM)...
February 3, 2018: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/29376624/investigation-of-non-saphenous-veins-in-c0s-patients
#14
Marzia Lugli, Oscar Maleti, M Letizia Iabichella, Michel Perrin
BACKGROUND: C0S patients have symptoms of chronic venous disorder (CVD), though an anatomical or pathophysiological explanation is lacking. C0 and C1 classified lower limbs can present with valve incompetence from the second to sixth generation of tributaries of saphenous veins despite the absence of a detectable saphenous truncal reflux. We hypothesized that C0S venous symptoms could stem from the second to sixth generation of saphenous tributaries and small veins that are not connected to the saphenous system...
January 26, 2018: International Angiology: a Journal of the International Union of Angiology
https://www.readbyqxmd.com/read/29364731/yc-1-inhibits-vegf-and-inflammatory-mediators-expression-on-experimental-central-retinal-vein-occlusion-in-rhesus-monkey
#15
Zhipeng Yan, Jianbin An, Qingli Shang, Nalei Zhou, Jingxue Ma
PURPOSES: To investigate the therapeutic potential of YC-1 for experimental central retinal vein occlusion (CRVO) of rhesus monkey. METHODS: Six adult rhesus monkeys were recruited in this study. Laser-induced CRVO was established in both eyes of all subjects. Intravitreal injection of YC-1 90 μl (200 μM with 0.01% dimethyl sulfoxide (DMSO) as vehicle) was administrated in right eye and 0.01% DMSO 90 μl in left eye respectively at 1 week after CRVO established...
January 24, 2018: Current Eye Research
https://www.readbyqxmd.com/read/29356690/bacterial-biofilms-on-extracorporeal-membrane-oxygenation-catheters
#16
Hye Ju Yeo, Seong Hoon Yoon, Seung Eun Lee, Woo Hyun Cho, Dohyung Kim, Doosoo Jeon, Kyung-Hwa Shin, Yun Seong Kim
Despite the advantages of extracorporeal membrane oxygenation (ECMO), secondary catheter infection remains a major concern during ECMO support. In this study, to clarify the mechanism of ECMO catheter-related infection, we evaluated the impact of infection on biofilm formation on the surfaces of ECMO catheters, and we investigated clinical factors associated with biofilm formation. Catheters used for ECMO were prospectively collected aseptically from the femoral vein, internal jugular vein, and femoral artery of 81 patients with acute cardiorespiratory failure between January 2015 and October 2016...
January 18, 2018: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/29349383/endovascular-extraction-of-a-migrated-large-self-expanding-laser-cut-renal-venous-stent-from-the-right-ventricle
#17
Tim Sebastian, Gabor Erdoes, Vlad A Bratu, Iris Baumgartner, Nils Kucher
Endovascular stent placement for decompression of an entrapped left renal vein (LRV) between the aorta and superior mesenteric artery is an alternative to surgical decompression for treating the nutcracker syndrome. However, an interventional approach may be challenging because of the unfavorable configuration of the LRV, leading to insufficient stent anchoring. We provide a case of a life-threatening stent migration from the LRV into the right ventricle 2 days after stent placement and its endovascular retrieval...
June 2017: Journal of Vascular Surgery Cases and Innovative Techniques
https://www.readbyqxmd.com/read/29326812/endovascular-laser-treatment-of-incompetent-saphenous-veins-using-the-1470-nm-diode-laser-and-radial-fiber
#18
Georgios Vourliotakis, Georgios Sahsamanis, Paschalis Evagelidis, Christina Aivatidi
Objectives: To assess the technical success, complications, and patients' quality of life (QoL) after treatment of chronic venous disease (CVD) using the 1470 nm radial fiber laser. Methods: A total of 170 patients with chronic venous disease, classified as C2 to C4 according to CEAP classification, were treated for incompetent greater (GSV) and small (SSV) saphenous veins, using the 1470 nm radial fiber laser and application of tumescent anesthesia. Additional phlebectomies were performed through stab microincisions, while 11 patients further underwent sclerotherapy intraoperatively...
January 2018: Annals of Medicine and Surgery
https://www.readbyqxmd.com/read/29318471/aav-mediated-gene-delivery-of-the-calreticulin-anti-angiogenic-domain-inhibits-ocular-neovascularization
#19
Leilei Tu, Jiang-Hui Wang, Veluchamy A Barathi, Selwyn M Prea, Zheng He, Jia Hui Lee, James Bender, Anna E King, Grant J Logan, Ian E Alexander, Youn-Shen Bee, Ming-Hong Tai, Gregory J Dusting, Bang V Bui, Jingxiang Zhong, Guei-Sheung Liu
Ocular neovascularization is a common pathological feature in diabetic retinopathy and neovascular age-related macular degeneration that can lead to severe vision loss. We evaluated the therapeutic efficacy of a novel endogenous inhibitor of angiogenesis, the calreticulin anti-angiogenic domain (CAD180), and its functional 112-residue fragment, CAD-like peptide 112 (CAD112), delivered using a self-complementary adeno-associated virus serotype 2 (scAAV2) in rodent models of oxygen-induced retinopathy and laser-induced choroidal neovascularization...
January 9, 2018: Angiogenesis
https://www.readbyqxmd.com/read/29285621/five-year-clinical-outcomes-of-visually-guided-laser-balloon-pulmonary-vein-isolation-for-the-treatment-of-paroxysmal-atrial-fibrillation
#20
Bruno Reissmann, Thorsten Budelmann, Erik Wissner, Michael Schlüter, Christian-Hendrik Heeger, Shibu Mathew, Tilman Maurer, Christine Lemes, Thomas Fink, Andreas Rillig, Francesco Santoro, Johannes Riedl, Feifan Ouyang, Karl-Heinz Kuck, Andreas Metzner
BACKGROUND: Visually guided laser balloon (VGLB) ablation allows for pulmonary vein isolation (PVI) under direct endoscopic control. Short- and midterm clinical outcomes are in accordance with results of radiofrequency current (RFC) ablation for the treatment of paroxysmal atrial fibrillation (PAF). OBJECTIVE: The current study sought to assess the long-term clinical outcomes of VGLB-based PVI for PAF. METHODS: A total of 90 patients [60 ± 10 years; 33 (37%) female, left atrial diameter 42 ± 4 mm] with drug-refractory PAF underwent VGLB ablation...
December 28, 2017: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
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