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https://www.readbyqxmd.com/read/28210901/transplantation-of-lineage-negative-stem-cells-in-pterygopalatine-artery-ligation-induced-retinal-ischemia-reperfusion-injury-in-mice
#1
Gillipsie Minhas, Sudesh Prabhakar, Ryuichi Morishita, Munehisa Shimamura, Reema Bansal, Akshay Anand
Retinal ischemia is a condition associated with retinal degenerative diseases such as glaucoma, diabetic retinopathy, and other optic neuropathies, leading to visual impairment and blindness worldwide. Currently, there is no therapy available for ischemic retinopathies. Therefore, the aim of this study was to test a murine model of pterygopalatine artery ligation-induced retinal injury for transplantation of mouse bone marrow-derived lineage-negative (lin-ve) stem cells. The mouse external carotid artery and pterygopalatine artery were ligated for 3...
February 16, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28203470/unusual-presentation-of-type-1-idiopathic-macular-telangiectasia
#2
Zaïnab Bentaleb Machkour, Philippe Denis, Laurent Kodjikian
Purpose. To report unusual presentation of type 1A idiopathic macular telangiectasia (IMT). Methods. Two middle-aged women with bilateral IMT were examined. Results. Both patients presented with a gradual vision loss in both eyes. Fundus examination was unremarkable in one case and showed small macular telangiectasia in both eyes in the other case. Fluorescein angiography (FA) revealed early bilateral macular punctuated hyperfluorescence corresponding to the dilated capillaries in both cases. FA and fundus examination confirmed also the absence of vascular abnormalities in the middle or anterior fundus periphery in one case...
2017: Case Reports in Ophthalmological Medicine
https://www.readbyqxmd.com/read/28203193/recurrent-uveal-effusion-after-laser-iridotomy
#3
Hiroshi Sakai, Michiko Yonahara, Miyako Sakai
A 59-year-old woman was seen by an ophthalmologist for blurred vision, ocular pain, headache, and nausea. She was diagnosed with acute primary angle closure (APAC) and successfully treated with medications. Using ultrasound biomicroscopy (UBM), engorged episcleral vein was observed and small uveal effusion was diagnosed after laser peripheral iridotomy (LPI). The uveal effusion disappeared and was again diagnosed by UBM together with anterior segment inflammation with ocular pain. Iritis caused by LPI after APAC might be a cause of uveal effusion in this specific case...
January 2017: Case Reports in Ophthalmology
https://www.readbyqxmd.com/read/28187470/-indications-for-retinal-laser-therapy-revisited
#4
P Enders, F Schaub, S Fauser
Background Laser therapy is an important treatment option in retinal diseases, especially in cases of vascular involvement. Most approaches are based on coagulation of retinal structures. As there is increasing use of agents targetting vascular endothelial growth factor in the treatment of macular diseases, indications for the use of laser treatment need to be reviewed carefully, especially with respect to their significance in first line therapy. This article explains recent strategies and treatment protocols...
February 10, 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/28151838/retinal-blood-flow-after-intravitreal-bevacizumab-is-a-predictive-factor-for-outcomes-of-macular-edema-associated-with-central-retinal-vein-occlusion
#5
Makiko Matsumoto, Kiyoshi Suzuma, Yoshihisa Yamada, Eiko Tsuiki, Azusa Fujikawa, Takashi Kitaoka
PURPOSE: To investigate whether retinal blood flow levels after intravitreal bevacizumab (IVB) treatment are correlated with the outcomes of patients with macular edema secondary to central retinal vein occlusion. METHODS: This retrospective observational case study enrolled 44 cases nonischemic central retinal vein occlusion. In each patient, visual acuity, central retinal thickness, and mean blur rate, which was measured by laser speckle flowgraphy and represents retinal blood flow velocity, were examined...
February 1, 2017: Retina
https://www.readbyqxmd.com/read/28139903/endovenous-laser-ablation-in-patients-with-severe-primary-chronic-venous-insufficiency
#6
Vladimir Starodubtsev, Mikhail Lukyanenko, Andrey Karpenko, Pavel Ignatenko
BACKGROUND: The aim of study was to estimate the safety and efficacy of using laser wavelength of 1560 nm with the foam sclerotherapy (FS) of varicose veins (VVs) for the treatment of severe primary chronic venous insufficiency (CVI, C4-C6) in patients with different diameters of the proximal segment (DPS) of the great saphenous vein (GSV). METHODS: We have separated the patients into two groups depending on the size of GSV: group 1 (281 cases; DPS of GSV less than 15 mm) and group 2 (210 cases; DPS of GSV more than 15 mm)...
January 31, 2017: International Angiology: a Journal of the International Union of Angiology
https://www.readbyqxmd.com/read/28134021/endovenous-laser-treatment-of-groin-and-popliteal-varicose-veins-recurrence
#7
Alvise Cavallini, Daniela Marcer, Salvatore Ferrari Ruffino
Objectives Recurrent varicose veins following surgery is a common, complex and costly problem in vascular surgery. Treatment for RVV is technically more difficult to perform and patient satisfaction is poorer than after primary interventions. Nevertheless, traditional vein surgery has largely been replaced by percutaneous office-based procedures, and the patients with recurrent varicose veins have not benefited from the same advantages. In this paper, we propose an endovascular laser treatment that allows reducing the invasiveness and complications in case of SFJ and SPJ reflux after ligation and stripping of the great and small saphenous vein...
January 1, 2017: Phlebology
https://www.readbyqxmd.com/read/28127735/effects-of-panretinal-laser-photocoagulation-on-the-corneal-nerve-plexus-and-retinal-nerve-fiber-layer-in-retinal-vein-occlusion
#8
Gulfidan Bitirgen, Selman Belviranli, Rayaz A Malik, Hurkan Kerimoglu, Ahmet Ozkagnici
PURPOSE: To determine the effects of panretinal photocoagulation (PRP) on corneal sub-basal nerve plexus (SBNP) and peripapillary retinal nerve fiber layer (RNFL) thickness in patients with unilateral central retinal vein occlusion (CRVO) who had previously undergone PRP treatment. METHODS: Sixty-four eyes of 32 patients (19 male, 13 female) with unilateral ischemic type CRVO who had undergone PRP treatment at least 6 months previously were included in this cross-sectional study...
January 23, 2017: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/28123979/minimally-invasive-treatments-for-perforator-vein-insufficiency
#9
REVIEW
Gokhan Kuyumcu, Gloria Maria Salazar, Anand M Prabhakar, Suvranu Ganguli
Incompetent superficial veins are the most common cause of lower extremity superficial venous reflux and varicose veins; however, incompetent or insufficient perforator veins are the most common cause of recurrent varicose veins after treatment, often unrecognized. Perforator vein insufficiency can result in pain, skin changes, and skin ulcers, and often merit intervention. Minimally invasive treatments have replaced traditional surgical treatments for incompetent perforator veins. Current minimally invasive treatment options include ultrasound guided sclerotherapy (USGS) and endovascular thermal ablation (EVTA) with either laser or radiofrequency energy sources...
December 2016: Cardiovascular Diagnosis and Therapy
https://www.readbyqxmd.com/read/28119106/comparison-of-ultrasound-guided-endovenous-laser-ablation-and-radiofrequency-for-the-varicose-veins-treatment-an-updated-meta-analysis
#10
REVIEW
Zhiguang He, Chenhong Zheng, Hongpeng Zhang, Ming-An Yu
PURPOSE: To investigate and compare the relative efficacy, recurrence and complications of endovenous laser ablation (EVLA) and radiofrequency ablation (RFA) for the treatment of varicose veins patients. METHODS: Searches were applied to the Cochrane Library as well as MEDLINE, EMBASE, BIOSIS databases. 12 articles published in English (10 randomized controlled trials and 2 cohort study) were identified from specialized trails. Fixed effect model and Random effect model were applied to compare the vein ablated length, pain scores (3days and 10days), quality of Life, occlusion, over all complication, thrombophlebitis, haematoma and recanalization between the EVLA and RFA group...
January 21, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28108378/the-pressure-induced-deformation-response-of-the-human-lamina-cribrosa-analysis-of-regional-variations
#11
Dan E Midgett, Mary E Pease, Joan L Jefferys, Mohak Patel, Christian Franck, Harry A Quigley, Thao D Nguyen
: The objective of this study was to measure the pressure-induced deformation response of the human lamina cribrosa (LC) and analyze for variations with age and anatomical region. The posterior scleral cup of 8 eyes from 6 human donors was mounted onto a custom inflation chamber. A laser-scanning microscope was used for second harmonic generation (SHG), imaging the collagen structure in the posterior volume of the LC at pressures from 5 mmHg to 45 mmHg. The SHG volumes were analyzed by the Fast-Fourier Iterative Digital Volume Correlation (DVC) algorithm for the three dimensional (3D) displacement field...
January 17, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28107458/neuropilin-1-involvement-in-choroidal-and-retinal-neovascularisation
#12
Patricia Fernández-Robredo, Senthil Selvam, Michael B Powner, Dawn A Sim, Marcus Fruttiger
PURPOSE: Inhibiting VEGF is the gold standard treatment for neovascular age-related macular degeneration (AMD). It is also effective in preventing retinal oedema and neovascularisation (NV) in diabetic retinopathy (DR) and retinal vein occlusions (RVO). Neuropilin 1 (Nrp1) is a co-receptor for VEGF and many other growth factors, and therefore a possible alternative drug target in intra ocular neovascular disease. Here we assessed choroidal and retinal NV in an inducible, endothelial specific knock out model for Nrp1...
2017: PloS One
https://www.readbyqxmd.com/read/28089779/percutaneous-coronary-intervention-of-chronically-occluded-saphenous-vein-grafts-using-excimer-laser-atherectomy-as-an-adjuvant-therapy
#13
Mohsen Mohandes, Sergio Rojas, Mauricio Torres, Cristina Moreno, Francisco Fernández, Jordi Guarinos, Alfredo Bardají
We present two cases with chronic total occlusion of the saphenous vein graft in two patients with a history of previous bypass surgery with unfavorable anatomic features for recanalization of the native coronary artery. In the first case, two dedicated attempts for recanalization of chronic total occlusion of the native artery failed and in the second case there was not an adequate visualization of the native vessel beyond the occlusion point, not even by contralateral injection. Excimer laser atherectomy was used in both cases as an adjuvant therapy during recanalization of the saphenous vein graft in combination with a distal protection device in order to reduce distal embolization...
December 27, 2016: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://www.readbyqxmd.com/read/28074839/high-precision-non-invasive-anti-microvascular-approach-via-concurrent-ultrasound-and-laser-irradiation
#14
Zizhong Hu, Haonan Zhang, Aghapi Mordovanakis, Yannis M Paulus, Qinghuai Liu, Xueding Wang, Xinmai Yang
Antivascular therapy represents a proven strategy to treat angiogenesis. By applying synchronized ultrasound bursts and nanosecond laser irradiation, we developed a novel, selective, non-invasive, localized antivascular method, termed photo-mediated ultrasound therapy (PUT). PUT takes advantage of the high native optical contrast among biological tissues and can treat microvessels without causing collateral damage to the surrounding tissue. In a chicken yolk sac membrane model, under the same ultrasound parameters (1 MHz at 0...
January 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28070820/development-of-a-new-catheter-prototype-for-laser-thrombolysis-under-guidance-of-optical-coherence-tomography-oct-validation-of-feasibility-and-efficacy-in-a-preclinical-model
#15
Rouven Berndt, Rene Rusch, Lars Hummitzsch, Matthias Lutz, Katharina Heß, Katharina Huenges, Bernd Panholzer, Christoph Otte, Assad Haneya, Georg Lutter, Alexander Schlaefer, Jochen Cremer, Justus Groß
In this feasibility study, a novel catheter prototype for laser thrombolysis under the guidance of optical coherence tomography (OCT) was designed and evaluated in a preclinical model. Human arteries and veins were integrated into a physiological flow model and occluded with thrombi made from the Chandler Loop. There were four experimental groups: placebo, 20 mg alteplase, laser, 20 mg alteplase + laser. The extent of thrombolysis was analyzed by weighing, OCT imaging and relative thrombus size. In the alteplase group, thrombus size decreased to 0...
January 9, 2017: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/28055098/glial-cell-contribution-to-basal-vessel-diameter-and-pressure-initiated-vascular-responses-in-rat-retina
#16
Hui Li, Bang V Bui, Grant Cull, Fang Wang, Lin Wang
Purpose: The purpose of this study was to test the hypothesis that retinal glial cells modify basal vessel diameter and pressure-initiated vascular regulation in rat retina. Methods: In rats, L-2-aminoadipic acid (LAA, 10 nM) was intravitreally injected to inhibit glial cell activity. Twenty-four hours following injection, retinal glial intracellular calcium (Ca2+) was labeled with the fluorescent calcium indicator Fluo-4/AM (F4, 1 mM). At 110 minutes after injection, intraocular pressure (IOP) was elevated from 20 to 50 mm Hg...
January 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28050474/technique-efficiency-and-safety-of-different-nerve-blocks-for-analgesia-in-laser-ablation-and-sclerotherapy-for-lower-limb-superficial-venous-insufficiency-a-multicentre-experience
#17
Krishna Prasad Premnath Bellam, Binu Joy, Abhilash Sandhyala, Kiran Naiknaware, Brijesh Ray, Vijayakumar
INTRODUCTION: Laser ablation and sclerotherapy, as minimally invasive alternatives to surgery for varicose veins, have good efficacy, safety and cosmetic result. Some form of anaesthesia is generally used for pain control. AIM: To describe the technique and evaluate the efficacy and safety of femoral, saphenous and sciatic nerve blocks in isolation or in combination for analgesia during laser ablation and sclerotherapy for lower limb varicose veins. MATERIALS AND METHODS: In this prospective observational study, over a period of 33 months, in 856 limbs of 681 patients with varicose veins, ultrasound guided femoral, saphenous and sciatic nerve blocks for analgesia were performed in 769, 808 and 52 instances respectively; following which, endovenous laser ablation, sclerotherapy or combination of both were carried out using standard practice...
November 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28043211/comparison-of-heat-induced-damage-at-the-saphenofemoral-junction-after-ablation-with-1-470-nm-laser-or-radiofrequency
#18
Evren Ozcinar, Mehmet Cakici, Oktay Korun, Unsal Han, Ugursay Kiziltepe
BACKGROUND: The aim of this study was to evaluate the heat induced damage at the saphenofemoral junction level according to histopathological changes after radiofrequency or 1,470 nm radial tip laser ablation. PATIENTS AND METHODS: Varicose vein segments of 6-10 mm in diameter were exposed to radiofrequency (Closure Fast catheter, 7 cm heat segment, one cycle, 15 seconds, 10 Watt, 120 °C) or laser ablation (1,470 nm radial tip, continuous wave, vein diameter: 6 cm/8 cm/10 cm-power: 10 Watt-pullback speed: 2...
January 3, 2017: VASA. Zeitschrift Für Gefässkrankheiten
https://www.readbyqxmd.com/read/28033234/associations-between-macular-edema-and-circulatory-status-in-eyes-with-retinal-vein-occlusion-an-adaptive-optics-scanning-laser-ophthalmoscopy-study
#19
Yuto Iida, Yuki Muraoka, Akihito Uji, Sotaro Ooto, Tomoaki Murakami, Kiyoshi Suzuma, Akitaka Tsujikawa, Shigeta Arichika, Ayako Takahashi, Yuko Miwa, Nagahisa Yoshimura
PURPOSE: To investigate associations between parafoveal microcirculatory status and foveal pathomorphology in eyes with macular edema (ME) secondary to retinal vein occlusion (RVO). METHODS: Ten consecutive patients (10 eyes) with acute retinal vein occlusion were enrolled, 9 eyes of which received intravitreal ranibizumab (IVR) injections. Foveal morphologic changes were examined via optical coherence tomography (OCT), and parafoveal circulatory status was assessed via adaptive optics scanning laser ophthalmoscopy (AO-SLO)...
December 28, 2016: Retina
https://www.readbyqxmd.com/read/28018497/morphological-comparison-of-blood-vessels-that-were-heated-with-a-radiofrequency-device-or-a-1470-nm-laser-and-a-radial-2ring-fiber
#20
Takashi Yamamoto, Masahiro Sakata
Introduction: Radio waves and lasers can be used as heat sources during endovenous thermal ablation (EVTA) for saphenous vein insufficiency. A morphological comparison of veins that had been treated with EVTA was performed between those treated with an endovenous closure system (a radiofrequency [RF] system) and those treated with a Radial 2Ring fiber connected to a 1470-nm laser generator (2R). Methods: The experiment was conducted in a system that reproduces the physiological conditions found in the saphenous veins during EVTA...
2016: Annals of Vascular Diseases
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