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https://www.readbyqxmd.com/read/29907232/intramuscular-e-selectin-adeno-associated-virus-gene-therapy-promotes-wound-healing-in-an-ischemic-mouse-model
#1
Punam P Parikh, Roberta M Lassance-Soares, Hongwei Shao, Manuela M Regueiro, Yan Li, Zhao-Jun Liu, Omaida C Velazquez
BACKGROUND: Poor wound healing in critical limb ischemia (CLI) is attributed to impaired neovascularization and reperfusion. Optimizing the ischemic wound with adhesion molecules that enhance stem cell homing may revolutionize treatment. The purpose of this study is to test the efficacy of adhesion molecule E-selectin on wound healing in an ischemic mouse wound. METHODS: Adult FVB/NJ mice underwent unilateral femoral artery and vein ligation to induce CLI. A 4-mm punch biopsy wound was created on the anterior thigh to simulate ischemic wounds...
August 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29901424/phenotyping-the-microvasculature-in-critical-sized-calvarial-defects-via-multimodal-optical-imaging
#2
Adam Mendez, Alexandra N Rindone, Namrata Batra, Pegah Abassnia, Janaka Senarathna, Stacy Gil, Darian H Hadjiabadi, Warren L Grayson, Arvind P Pathak
Tissue engineered scaffolds are a powerful means of healing craniofacial bone defects arising from trauma or disease. Murine models of critical-sized bone defects are especially useful in understanding the role of microenvironmental factors such as vascularization on bone regeneration. Here we demonstrate the capability of a novel multimodality imaging platform capable of acquiring in vivo images of microvascular architecture, microvascular blood flow and tracer/cell tracking via intrinsic optical signaling (IOS), laser speckle contrast (LSC) and fluorescence imaging, respectively in a critical-sized calvarial defect model...
June 14, 2018: Tissue Engineering. Part C, Methods
https://www.readbyqxmd.com/read/29895399/a-systematic-review-and-meta-analysis-of-thrombotic-events-following-endovenous-thermal-ablation-of-the-great-saphenous-vein
#3
REVIEW
Donagh A Healy, Shiori Kimura, David Power, Abubaker Elhaj, Yasser Abdeldaim, Keith S Cross, Gerard T McGreal, Paul E Burke, Tony Moloney, Brian J Manning, Eamon G Kavanagh
OBJECTIVES: A systematic review and meta-analysis was performed to determine the incidence of thrombotic events following great saphenous vein (GSV) endovenous thermal ablation (EVTA). METHODS: MEDLINE, Embase and conference abstracts were searched. Eligible studies were randomised controlled trials and case series that included at least 100 patients who underwent GSV EVTA (laser ablation or radiofrequency ablation [RFA]) with duplex ultrasound (DUS) within 30 days...
June 9, 2018: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/29894362/video-assisted-thoracoscopic-monitoring-of-laser-lead-extraction-by-femoral-route
#4
Luca Bontempi, Francesca Vassanelli, Manuel Cerini, Lorenza Inama, Gianfranco Mitacchione, Daniele Giacopelli, Antonio Curnis
A 72-year-old man with a dual-chamber implantable defibrillator was referred to our center for transvenous lead extraction because of pocket infection and presence of an abandoned lead. We decided to proceed with a video-assisted thoracoscopic approach because of patient history and documented complete occlusion of the right subclavian vein. During the use of excimer laser for persistent adhesions, the ventricular lead broke down at the level of cavoatrial junction. To successfully remove the remaining portion of lead, we decided to use the excimer laser by femoral route...
June 11, 2018: Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery
https://www.readbyqxmd.com/read/29873404/smartphone-imaging-of-subcutaneous-veins
#5
William Lewis, Walfre Franco
OBJECTIVE: The identification of veins by medical personnel is a critical skill that is necessary to draw blood or administer intravenous fluids and medications. Because a normal consumer camera can act as a multispectral imaging apparatus, operating with three broadband detectors, we hypothesized that a standard smartphone camera might be employed for enhanced visualization of veins in human skin. STUDY: Video and images of subcutaneous veins were acquired using the rear-facing iSight camera from an iPhone 6, with a fixed aperture of f/2...
June 6, 2018: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/29808323/foaming-of-blood-in-endovenous-laser-treatment
#6
Vladimir Chudnovskii, Aleksandr Mayor, Artem Kiselev, Vladimir Yusupov
This work is dedicated to a challenging issue of modern phlebology-establishment of a physical mechanism of the endovenous laser treatment (EVLT) against great saphenous vein incompetence (protuberant varicosities). Using optical and acoustical methods, we have studied the laser-induced formation of microbubbles in an aqueous solution of surface-active substances, serum, and blood directly in patients while conducting EVLT of the great saphenous vein in a clinical setting. We have used lasers with wavelengths 0...
May 28, 2018: Lasers in Medical Science
https://www.readbyqxmd.com/read/29804500/comparison-of-the-effects-of-endovenous-laser-ablation-at-1470-nm-versus-1940-nm-and-different-energy-densities
#7
Walter Junior Boim de Araujo, Jorge Rufino Ribas Timi, Luiz Roberto Kotze, Cleber Rafael Vieira da Costa
Objectives To evaluate histological and immunohistochemical changes in the great saphenous vein after endovenous laser ablation at two different wavelengths (1470 vs. 1940 nm) and linear endovenous energy density values (50 vs. 100 J/cm). Method Segments were obtained from the conventional eversion removal of great saphenous vein and divided into a control group and four groups for ex vivo irradiation (control group; A: 1470 nm, 50 J/cm; B: 1470 nm, 100 J/cm; C: 1940 nm, 50 J/cm; D: 1940 nm, 100 J/cm)...
January 1, 2018: Phlebology
https://www.readbyqxmd.com/read/29786420/bacteria-driven-hypoxia-targeting-for-combined-biotherapy-and-photothermal-therapy
#8
Wenfei Chen, Ying Wang, Ming Qin, Xudong Zhang, Zhirong Zhang, Xun Sun, Zhen Gu
The facultative anaerobe Salmonella strain VNP20009 selectively colonizes into tumors following systemic injection due to its preference for the hypoxia in the tumor cores. However, the Phase 1 Clinical Trial of VNP20009 has been terminated mainly due to its weak anti-tumor effects and exhibition of dose-dependent toxicity. Here we leveraged the advantages of VNP20009 biotherapy together with polydopamine-mediated photothermal therapy in order to enhance the antitumor efficacy toward malignant melanoma. VNP20009 was coated with polydopamine via oxidation and self-polymerization, which was then injected into tumor-bearing mice via the tail vein...
May 22, 2018: ACS Nano
https://www.readbyqxmd.com/read/29781902/endovenous-thermal-ablation-of-recurrent-varicose-veins-due-to-residual-great-saphenous-venous-insufficiency-after-saphenous-venous-surgery-a-comparative-study
#9
Jin Ho Hwang, Sang Woo Park, Il Soo Chang, Ki Hyun Kim, Ji Hun Kang
BACKGROUND: Redo surgery for recurrent varicose veins of the great saphenous vein (GSV) is technically more challenging than the initial surgery. OBJECTIVE: To compare 980 and 1,470-nm endovenous laser ablation (EVLA) and radiofrequency ablation (RFA) for the treatment of residual GSV insufficiency after saphenofemoral ligation ± stripping. MATERIALS AND METHODS: Thirty-seven limbs in 29 patients with recurrent varicose veins were retrospectively evaluated...
May 16, 2018: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/29777845/recanalization-after-endovenous-thermal-ablation
#10
Afsha Aurshina, Ahmad Alsheekh, Pavel Kibrik, Anil Hingorani, Natalie Marks, Enrico Ascher
OBJECTIVE: Endovenous thermal ablation in the form of radiofrequency ablation (RFA) or endovenous laser ablation (EVLA) has quickly ascended to a prime position in the treatment of venous insufficiency. While there is good data examining the rates of thrombotic complications, there is a relative paucity of data examining the recanalization rates after endovenous thermal ablation (ETA). METHODS: Data analysis was performed for 1475 thermal ablations in 485 patients from 2012-2015 as a retrospective chart review...
May 16, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29772323/endovascular-treatment-for-iliofemoral-vein-thrombosis-with-composite-stents
#11
Liangxi Yuan, Ye Lu, Guanglang Zhu, Tianchi Hu, Xiaoyu Sun, Junmin Bao, Qingsheng Lu, Zaiping Jing
OBJECTIVES: To evaluate the applicability of endovascular treatment for iliofemoral vein thrombosis with composite stents. METHODS: Between September 2013 and August 2016, 29 consecutive patients underwent endovascular therapy with composite stents for iliofemoral vein thrombosis and were followed up at our institution. All the patients with acute or chronic iliofemoral vein thrombosis enrolled in this study were evaluated by colour Doppler ultrasonography and diagnosed by venography...
May 14, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29761077/anatomical-cadaver-study-of-endolaryngeal-vascularization-focus-on-the-glottis-supraglottis-and-subglottis-from-the-transoral-microsurgical-point-of-view
#12
Pietro Perotti, Marco Ferrari, Nausica Montalto, Davide Lancini, Alberto Paderno, Fabiola Incandela, Barbara Buffoli, Luigi Fabrizio Rodella, Cesare Piazza
Introduction: Carbon dioxide laser coagulation during transoral laser microsurgery (TLM) for laryngeal cancer allows control of bleeding from vessels smaller than 0.5 mm. Therefore, larger arteries and veins must be carefully managed by clipping and/or monopolar cautery. The aim of this paper is to detail endolaryngeal vascular anatomy and identify areas of possible bleeding during TLM. Methods: We performed an anatomical study on a series of 11 fresh-frozen human cadavers...
2018: Frontiers in Oncology
https://www.readbyqxmd.com/read/29757059/quantitative-hemodynamic-analysis-of-cerebral-blood-flow-and-neurovascular-coupling-using-optical-coherence-tomography-angiography
#13
Paul Shin, WooJhon Choi, JongYoon Joo, Wang-Yuhl Oh
Functional hyperemia in the rat cortex was investigated using high-speed optical coherence tomography (OCT) angiography and Doppler OCT. OCT angiography (OCTA) was performed to image the hemodynamic stimulus-response over a wide field of view. Temporal changes in vessel diameters in different vessel compartments, which were determined as the diameters of erythrocyte flows in OCT angiograms, were measured in order to monitor localized hemodynamic changes. Our results showed that the dilation of arterioles at the site of activation was accompanied by the dilation of upstream arteries...
January 1, 2018: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/29744040/recent-advances-in-understanding-and-managing-retinal-vein-occlusions
#14
REVIEW
Daniel D Esmaili, David S Boyer
Retinal vein occlusions are the second most common form of retinal vascular disease. Previously, laser treatment for branch retinal vein occlusion and intravitreal triamcinolone acetonide for central retinal vein occlusion were the standard of care. Recent studies have demonstrated that anti-vascular endothelial growth factor (anti-VEGF) agents have a superior safety and efficacy profile for the treatment of both branch and central retinal vein occlusions. The use of wide-field fluorescein angiography has also allowed better visualization of the retinal periphery...
2018: F1000Research
https://www.readbyqxmd.com/read/29732527/electrical-isolation-of-the-superior-vena-cava-by-laser-balloon-ablation-in-patients-with-atrial-fibrillation
#15
Martín R Arceluz, Pedro F Cruz, Estela Falconi, Rosa Montes de Oca, Reina Delgado, Jorge Figueroa, Marta Ortega, José L Merino
PURPOSE: The aim of the present study is to evaluate the feasibility and safety of SVC electrical isolation by LB ablation in patients with atrial fibrillation (AF) referred for pulmonary vein isolation (PVI). METHODS: Electrical disconnection of the SVC was attempted by LB in 13 consecutive patients (59 ± 10.5 years, 11 male) with AF following PVI. PVI was successfully achieved by standard LB in all before attempting SVC isolation. RESULTS: A laser beam was delivered with 6...
May 7, 2018: Journal of Interventional Cardiac Electrophysiology: An International Journal of Arrhythmias and Pacing
https://www.readbyqxmd.com/read/29722522/reed-leaf-inspired-graphene-films-with-anisotropic-superhydrophobicity
#16
Hao-Bo Jiang, Yu-Qing Liu, Yong-Lai Zhang, Yan Liu, Xiu-Yan Fu, Dong-Dong Han, Yun-Yun Song, Luquan Ren, Hong-Bo Sun
Controlling the wettability of graphene and graphene derivatives is critical for broader applications. However, the dynamic dewetting performance of graphene is usually overlooked. Currently, superhydrophobic graphene with an anisotropic wettability is rare. Inspired by natural reed leaves, we report an ingenious fabrication process combining photolithography and laser holography technologies to create biomimetic graphene surfaces that demonstrate anisotropic wettability along two directions of grooved hierarchical structures, which are similar to reed leaf veins...
May 3, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29722466/post-procedural-lge-cmr-comparison-of-laser-and-radiofrequency-ablation-lesions-after-pulmonary-vein-isolation
#17
Rosa M Figueras I Ventura, Andrei D Mǎrgulescu, Eva M Benito, Francisco Alarcón, Norihiro Enomoto, Susanna Prat-Gonzalez, Rosario J Perea, Roger Borràs, Fredy Chipa, Elena Arbelo, Jose M Tolosana, Josep Brugada, Antonio Berruezo, Lluis Mont
INTRODUCTION: The purpose of this study was to compare the anatomical characteristics of scar formation achieved by visual guided laser balloon (Laser) and radiofrequency (RF) pulmonary vein isolation (PVI), using late-gadolinium-enhanced cardiac magnetic resonance imaging (LGE-CMR). METHODS AND RESULTS: We included 17 patients with paroxysmal or early persistent drug resistant AF who underwent Laser ablation; 2 were excluded due to procedure-related complications...
May 3, 2018: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/29705225/a-comparison-of-concomitant-tributary-laser-ablation-and-foam-sclerotherapy-in-patients-undergoing-truncal-endovenous-laser-ablation-for-lower-limb-varicose-veins
#18
Ji-Chang Wang, Yan Li, Guang-Yue Li, Yi Xiao, Wei-Ming Li, Qiang Ma, Jian-Lin Liu, Shao-Ying Lu
PURPOSE: To compare outcomes of patients who received simultaneous tributary endovenous laser ablation (EVLA) or foam sclerotherapy (FS) with EVLA of the great saphenous vein (GSV) trunk. METHODS AND MATERIALS: This study recruited 418 patients (542 legs) with diagnosed varicose veins. Patients in the EVLA/FS group (255 patients, 327 legs) received concomitant FS for the tributaries with truncal lasering. For the EVLA-alone group (163 patients, 215 legs), tributaries (8W) were ablated with EVLA in addition to the GSV trunk (14W)...
June 2018: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/29696993/comparison-of-ranibizumab-and-subthreshold-micropulse-laser-in-treatment-of-macular-edema-secondary-to-branch-retinal-vein-occlusion
#19
Yelda Buyru Özkurt, Sezen Akkaya, Sibel Aksoy, Mert Hakan Şimşek
PURPOSE: To compare the effects of intravitreal ranibizumab injection and yellow (577 nm) subthreshold micropulse laser treatment in patients with macular edema following non-ischemic branch retinal vein occlusion. METHODS: The medical records of 51 patients who underwent intravitreal ranibizumab (0.5 mg) injection or subthreshold micropulse laser for the treatment of macular edema due to branch retinal vein occlusion were retrospectively reviewed. Subthreshold micropulse laser was administered with a 10% duty cycle, 100 μm spot diameter, 200 ms exposure time...
April 1, 2018: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/29689025/combination-therapy-of-intravitreal-ranibizumab-and-subthreshold-micropulse-photocoagulation-for-macular-edema-secondary-to-branch-retinal-vein-occlusion-6-month-result
#20
Hiroko Terashima, Hiruma Hasebe, Fumiki Okamoto, Naoki Matsuoka, Yayoi Sato, Takeo Fukuchi
PURPOSE: To determine the efficacy of the combination therapy of intravitreal ranibizumab (IVR) and 577-nm yellow laser subthreshold micropulse laser photocoagulation (SMLP) for macular edema secondary to branch retinal vein occlusion cystoid macular edema. METHODS: Retrospective, consecutive, case-control study. Forty-six eyes of 46 patients with treatment-naive branch retinal vein occlusion cystoid macular edema were enrolled. The IVR + SMLP group consisted of 22 patients who had undergone both SMLP and IVR...
April 23, 2018: Retina
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