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Metformin AND B12

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https://www.readbyqxmd.com/read/28553599/serum-vitamin-b12-levels-in-type-2-diabetes-patients-on-metformin-compared-to-those-never-on-metformin-a-cross-sectional-study
#1
Nishant Raizada, Viveka P Jyotsna, Vishnubhatla Sreenivas, Nikhil Tandon
CONTEXT: There are limited data about the effect of metformin use on serum Vitamin B12 levels in type 2 diabetes patients from India. AIMS: We studied serum Vitamin B12 levels in patients with type 2 diabetes mellitus who were receiving metformin and compared them to those never treated with metformin. SUBJECTS AND METHODS: A total of 183 patients ("metformin" group 121, "no metformin" group 63) of type 2 diabetes from the endocrinology clinic of a tertiary care center in North India were studied...
May 2017: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28496346/do-we-need-to-measure-vitamin-b12-and-magnesium-in-morbidly-obese-patients-with-type-2-diabetes-mellitus
#2
Anna Wåhlén, Arvo Haenni, Hans-Erik Johansson
OBJECTIVE: We aimed to investigate the prevalence of B12 deficiency in metformin-treated, morbidly obese, type 2 diabetes mellitus (T2DM) patients, compared to morbidly obese controls, as well as to evaluate the magnesium status. DESIGN: Retrospective cross-sectional analysis of plasma vitamin B12, plasma magnesium, glucometabolic status and clinical measurements in all consecutive morbidly obese patients was conducted during 1 year. SETTING: Outpatient Clinic of Obesity Care...
2017: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy
https://www.readbyqxmd.com/read/28457771/-vitamin-b12-levels-in-the-patient-population-attending-an-urban-health-centre-in-madrid
#3
M Camarero-Shelly
INTRODUCTION: Vitamin B12 levels are usually measured in Primary Care when the patients have symptoms or risk factors associated with its deficiency, mostly in the elderly. However, no evidence has been found to support the recommendation of screening in the general population. The aim of this study is to assess the relevance of having extended the screening of vitamin B12 deficiency to a younger population, after observing an increase in the prescription of this injected vitamin in a population under 65 years, by analysing the vitamin B12 values obtained...
April 27, 2017: Semergen
https://www.readbyqxmd.com/read/28447237/effects-of-metformin-versus-placebo-on-vitamin-b12-metabolism-in-non-diabetic-breast-cancer-patients-in-cctg-ma-32
#4
Ana Elisa Lohmann, Mira F Liebman, William Brien, Wendy R Parulekar, Karen A Gelmon, Lois E Shepherd, Jennifer A Ligibel, Dawn L Hershman, Priya Rastogi, Ingrid A Mayer, Timothy J Hobday, Julie Lemieux, Alastair Mark Thompson, Kathleen I Pritchard, Timothy Joseph Whelan, Som D Mukherjee, Haji I Chalchal, Vanessa Bernstein, Vuk Stambolic, Bingshu E Chen, Pamela Jean Goodwin
BACKGROUND: Metformin is associated with low levels of vitamin B12 (VitB12) in patients with diabetes. The CCTG/MA.32 trial investigates the effects of metformin vs placebo on breast cancer (BC) outcomes in non-diabetic high-risk BC patients. We analyzed VitB12 at baseline and after 6 months of metformin (versus placebo) in the first 492 patients with paired blood samples. METHODS: VitB12 was analyzed centrally in baseline and 6-month fasting plasma. Levels <181 pmol/L were considered deficient, 181-221 pmol/L borderline, and ≥222 pmol/L sufficient...
April 26, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28231061/role-of-treatment-modifying-mthfr677c-t-and-1298a-c-polymorphisms-in-metformin-treated-puerto-rican-patients-with-type-2-diabetes-mellitus-and-peripheral-neuropathy
#5
Francisco J Jiménez-Ramírez, Liza M Castro, Clarymar Ortiz, Jennifer Concepción, Jessicca Y Renta, Raúl H Morales-Borges, Jorge R Miranda-Massari, Jorge Duconge
BACKGROUND: The study was conducted to investigate potential association between MTHFR genotypes and diabetic peripheral neuropathy (DPN) in Puerto Ricans with type-2 diabetes mellitus (T2DM) treated with metformin. The prevalence of major MTHFR polymorphisms in this cohort was also ascertained. METHODS: DNAs from 89 metformin-treated patients with T2DM and DPN were genotyped using the PCR-based RFLP assay for MTHFR677C>T and 1298A>C polymorphisms. Frequency distributions of these variants in the study cohort were compared to those reported for three reference populations (HapMap project) and controls (400 newborn specimens)...
March 1, 2017: Drug Metabolism and Personalized Therapy
https://www.readbyqxmd.com/read/28182265/long-term-metformin-therapy-and-monitoring-for-vitamin-b12-deficiency-among-older-veterans
#6
Vijaya Kancherla, John L Elliott, Birju B Patel, N Wilson Holland, Theodore M Johnson, Anjali Khakharia, Lawrence S Phillips, Godfrey P Oakley, Camille P Vaughan
OBJECTIVE: To examine the association between long-term metformin therapy and serum vitamin B12 monitoring. DESIGN: Retrospective cohort study. SETTING: A single Veterans Affairs Medical Center (VAMC), 2002-2012. PARTICIPANTS: Veterans 50 years or older with either type 2 diabetes and long-term metformin therapy (n = 3,687) or without diabetes and no prescription for metformin (n = 13,258). MEASUREMENTS: We determined diabetes status from outpatient visits, and defined long-term metformin therapy as a prescription ≥500 mg/d for at least six consecutive months...
May 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/28076635/prevalence-of-vitamin-b12-deficiency-in-type-2-diabetic-patients-using-metformin-a-cross-sectional-study
#7
Charbel Pereira Damião, Amannda Oliveira Rodrigues, Maria Fernanda Miguens Castellar Pinheiro, Rubens Antunes da Cruz, Gilberto Peres Cardoso, Giselle Fernandes Taboada, Giovanna Aparecida Balarini Lima
CONTEXT AND OBJECTIVE: The prevalence of vitamin B12 deficiency varies from 5.8% to 30% among patients undergoing long-term treatment with metformin. Because of the paucity of data on Brazilian patients, this study aimed to determine the frequency of B12 deficiency and related factors among Brazilian patients with type 2 diabetes mellitus (T2DM) using metformin. DESIGN AND SETTING: Cross-sectional study at a public university hospital. METHODS: Patients with T2DM and a control group of non-diabetics were included...
November 2016: São Paulo Medical Journal, Revista Paulista de Medicina
https://www.readbyqxmd.com/read/27867908/erratum-study-of-vitamin-b12-deficiency-and-peripheral-neuropathy-in-metformin-treated-early-type-2-diabetes-mellitus
#8
(no author information available yet)
[This corrects the article on p. 631 in vol. 20, PMID: 27730072.].
November 2016: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27806244/metformin-and-vitamin-b12-deficiency-where-do-we-stand
#9
Marwan Awad Ahmed
The association between metformin use and low vitamin B12 levels in type 2 diabetes mellitus patients is well-established. However, many aspects of the topic remain to be elucidated. There is still controversy on the current diagnostic approaches to vitamin B12 deficiency. It is now believed that measuring the serum levels of the vitamin may not reflect its metabolic status. Moreover, there were conflicting results from studies attempting to quantify and explore metformin-associated vitamin B12 deficiency and its clinical impacts...
July 2016: Journal of Pharmacy & Pharmaceutical Sciences: a Publication of the Canadian Society for Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27730072/study-of-vitamin-b12-deficiency-and-peripheral-neuropathy-in-metformin-treated-early-type-2-diabetes-mellitus
#10
Rudra Prasad Roy, Kaushik Ghosh, Manas Ghosh, Amitava Acharyya, Ambarish Bhattacharya, Mrinal Pal, Sisir Chakraborty, Nilanjan Sengupta
BACKGROUND: Long-term therapy with metformin was shown to decrease the Vitamin B12 level and manifested as peripheral neuropathy. AIM: The aim of this study is to define the prevalence of Vitamin B12 deficiency in early Type 2 diabetic patients (duration ≤5 years or drug treatment ≤3 years) and the relationship among metformin exposure and levels of cobalamin (Cbl), folic acid, and homocysteine (Hcy) with severity of peripheral neuropathy. METHODOLOGY: This is a cross-sectional study involving randomly selected ninety patients (male 56, female 34) between age groups of 35 and 70 years, comparing those who had received >6 months of metformin (Group A) (n = 35) with those without metformin (Group B) (n = 35) and patients taking metformin with other oral hypoglycemic agent (Group C) (n = 20)...
September 2016: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27728101/a-observational-study-in-patients-of-diabetes-using-metformin-causing-vitamin-b12-deficiency-causing-peripheral-neuropathy
#11
Shyamal Das, A Chakraborty
No abstract text is available yet for this article.
January 2016: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27716423/vitamin-b12-deficiency-in-metformin-treated-type-2-diabetes-patients-prevalence-and-association-with-peripheral-neuropathy
#12
Marwan A Ahmed, George Muntingh, Paul Rheeder
BACKGROUND: The association between long-term metformin use and low vitamin B12 levels has been proven. However, the prevalence estimates of metformin-induced vitamin B12 deficiency showed considerable variation among the studies. The potential of the deficiency to cause or worsen peripheral neuropathy in type-2 diabetes mellitus (T2DM) patients has been investigated with conflicting results. The aim of the study was to investigate: 1) the prevalence of vitamin B12 deficiency in T2DM patients on metformin; 2) the association between vitamin B12 and peripheral neuropathy; 3) and the risk factors for vitamin B12 deficiency in these patients...
October 7, 2016: BMC Pharmacology & Toxicology
https://www.readbyqxmd.com/read/27638143/vitamin-b12-deficiency-is-associated-with-cardiovascular-autonomic-neuropathy-in-patients-with-type-2-diabetes
#13
Christian S Hansen, Jan S Jensen, Martin Ridderstråle, Dorte Vistisen, Marit E Jørgensen, Jesper Fleischer
AIMS: Vitamin B12 deficiency could be associated with cardiovascular autonomic neuropathy (CAN) in diabetes patients. We aim to investigate the association between serum levels of vitamin B12 and CAN in type 2 diabetes patients. METHODS: 469 ambulatory type 2 diabetes patients (mean diabetes duration 10.0years (IQR 5.0;17.0), mean age 59.0years (SD 11.6), 63% men, mean B12 289.0pmol/l (IQR 217;390)) were screened for CAN using three cardiovascular reflex tests, five minute resting heart rate (5min RHR) and heart rate variability indices...
January 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/27570337/is-metformin-induced-vitamin-b12-deficiency-responsible-for-cognitive-decline-in-type-2-diabetes
#14
Deepti Khattar, Farah Khaliq, Neelam Vaney, S V Madhu
INTRODUCTION: Diabetes mellitus has its deleterious effects on various aspects of cognition such as memory function, executive function, and information-processing speed. The present study aims to assess cognition in diabetes patients and also tries to find its association with Vitamin B12 deficiency induced by metformin. MATERIALS AND METHODS: Thirty diabetics taking metformin and thirty nondiabetic controls were enrolled. Event-related potentials (ERPs) and serum Vitamin B12 levels were evaluated in them...
July 2016: Indian Journal of Psychological Medicine
https://www.readbyqxmd.com/read/27513580/multivitamin-use-and-serum-vitamin-b12-concentrations-in-older-adult-metformin-users-in-regards-2003-2007
#15
Vijaya Kancherla, Joshua V Garn, Neil A Zakai, Rebecca S Williamson, Winn T Cashion, Oluwaseun Odewole, Suzanne E Judd, Godfrey P Oakley
Metformin, an insulin-sensitizing drug, is a first line treatment for type 2 diabetes. Long-term use of metformin has been associated with subsequent reductions in vitamin B12 concentrations. The objective of our study was to determine whether metformin use is associated with lower serum vitamin B12 concentrations in older adults, and whether concurrent use of multivitamins modifies this association. We examined 2,510 participants aged 50 years and over, participating in the national population-based Reasons for Geographic And Racial Differences in Stroke (REGARDS) Study...
2016: PloS One
https://www.readbyqxmd.com/read/27358222/delayed-auditory-conduction-in-diabetes-is-metformin-induced-vitamin-b12-deficiency-responsible
#16
D Khattar, F Khaliq, N Vaney, S V Madhu
The present study aims to evaluate the functional integrity of the auditory pathway in patients with diabetes taking metformin. A further aim is to assess its association with vitamin B12 deficiency induced by metformin. Thirty diabetics taking metformin and 30 age-matched non-diabetic controls were enrolled. Stimulus-related potentials and vitamin B12 levels were evaluated in all the subjects. The diabetics showed deficient vitamin B12 levels and delayed wave III latency and III-V interpeak latency in the right ear and delayed Na and Pa wave latencies in the left ear compared with the controls...
April 2016: Functional Neurology
https://www.readbyqxmd.com/read/27355231/sublingual-vitamin-b12-compared-to-intramuscular-injection-in-patients-with-type-2-diabetes-treated-with-metformin-a-randomised-trial
#17
RANDOMIZED CONTROLLED TRIAL
Amber Parry-Strong, Fali Langdana, Sylvan Haeusler, Mark Weatherall, Jeremy Krebs
UNLABELLED: MAIM: To compare a single 1mg intramuscular hydroxocobalamin injection with a 3-month course of 1mg/day sublingual methylcobalamin supplements on serum vitamin B12 concentrations in participants withtype 2 diabetes treated with metformin. METHOD: Participants on metformin treatment with vitamin B12 concentrations below 220pmol/L were recruited through hospital diabetes clinics and primary care practices. They were randomised to receive either the injection or sublingual treatment...
June 10, 2016: New Zealand Medical Journal
https://www.readbyqxmd.com/read/27323792/comparison-of-2-population-health-management-approaches-to-increase-vitamin-b12-monitoring-in-patients-taking-metformin
#18
David E Matthews, Stuart J Beatty, Gail M Grever, Amy Lehman, Kelli D Barnes
BACKGROUND: Population health management uses proactive, targeted interventions to improve health outcomes. OBJECTIVES: To compare the effectiveness of and time required for 2 pharmacist-driven population health management interventions to improve vitamin B12 monitoring in patients taking metformin. METHODS: Physicians were randomized to 1 of 2 population health management interventions. For all patients of physicians assigned to the patient portal intervention, a pharmacist communicated need for vitamin B12 monitoring directly to the patient using an electronic patient portal...
October 2016: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/27276084/prevalence-of-vitamin-b12-deficiency-in-type-2-diabetic-patients-using-metformin-a-cross-sectional-study
#19
Charbel Pereira Damião, Amannda Oliveira Rodrigues, Maria Fernanda Miguens Castellar Pinheiro, Rubens Antunes da Cruz Filho, Gilberto Peres Cardoso, Giselle Fernandes Taboada, Giovanna Aparecida Balarini Lima
CONTEXT AND OBJECTIVE: The prevalence of vitamin B12 deficiency varies from 5.8% to 30% among patients undergoing long-term treatment with metformin. Because of the paucity of data on Brazilian patients, this study aimed to determine the frequency of B12 deficiency and related factors among Brazilian patients with type 2 diabetes mellitus (T2DM) using metformin. DESIGN AND SETTING: Cross-sectional study at a public university hospital. METHODS: Patients with T2DM and a control group of non-diabetics were included...
June 3, 2016: São Paulo Medical Journal, Revista Paulista de Medicina
https://www.readbyqxmd.com/read/27190787/association-between-serum-b12-and-serum-homocysteine-levels-in-diabetic-patients-on-metformin
#20
Twinkal R Upadhyay, Nitin Kothari, Hitesh Shah
INTRODUCTION: Type-2 Diabetes Mellitus (T2DM) and metformin both can lower serum B12 (s.B12). Raised serum Homocysteine (s.Hcy) is considered as an early marker of B12 deficiency. AIM: The study aimed to check whether homocysteine levels are more sensitive indicator of s. B12 deficiency or not among diabetics using metformin. MATERIALS AND METHODS: Mean s.B12 and s.Hcy levels of 30 cases (diabetics on metformin <5years) were compared with 30 diabetic controls not on metformin and 31 nondiabetic controls and statistically analysed by ANOVA and post-hoc tests...
April 2016: Journal of Clinical and Diagnostic Research: JCDR
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