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Ivermectin 1% cream

Stefanie Rosumeck, Alexander Nast, Corinna Dressler
BACKGROUND: Scabies is an intensely itchy parasitic infection of the skin. It occurs worldwide, but is particularly problematic in areas of poor sanitation, overcrowding, and social disruption. In recent years, permethrin and ivermectin have become the most relevant treatment options for scabies. OBJECTIVES: To assess the efficacy and safety of topical permethrin and topical or systemic ivermectin for scabies in people of all ages. SEARCH METHODS: We searched the following databases up to 25 April 2017: the Cochrane Infectious Diseases Group Specialized Register, CENTRAL, MEDLINE, Embase, LILACS, and IndMED...
April 2, 2018: Cochrane Database of Systematic Reviews
Anne-Sophie Smilga, Janie Bujold
Cutaneous larva migrans (CLM) is a zoonotic helminthiasis frequently imported to Canada by travellers to beach destinations in the tropics. The preferred treatment is oral ivermectin. We present a case of CLM acquired within the province of Quebec, a first in our provincial health records. Our case also puts forward the use of topical ivermectin as a possibly effective CLM treatment approach as our patient was successfully treated with 1 month of an ivermectin 1% cream applied locally twice daily.
January 1, 2018: Journal of Cutaneous Medicine and Surgery
M Schaller, L Gonser, K Belge, C Braunsdorf, R Nordin, A Scheu, C Borelli
BACKGROUND: Recently, therapy of rosacea with inflammatory lesions (papulopustular) has improved substantially with the approval of topical ivermectin 1% cream. It is assumed to have a dual mode of action with anti-inflammatory capacities and anti-parasitic effects against Demodex, which however has not yet been demonstrated in vivo. AIM: To find scientific rationale for the dual anti-inflammatory and anti-parasitic mode of action of topical ivermectin 1% cream in patients with rosacea...
November 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
Séverine Thibaut de Ménonville, Carine Rosignoli, Estelle Soares, Manon Roquet, Béatrice Bertino, Jean-Paul Chappuis, Claire Defoin-Platel/Chaussade, David Piwnica
INTRODUCTION: Numerous intrinsic and extrinsic factors have been associated with the pathophysiology of rosacea, including dysregulation of innate immunity. A high level of cathelicidin antimicrobial peptides (e.g., LL-37) has been shown in the facial skin of patients with rosacea. Excessive production of both LL-37 and KLK5, the serine protease responsible for its cleavage, has been suggested to play a role in the pathophysiology of rosacea. Ivermectin 10 mg/g cream, indicated for the treatment of inflammatory lesions of rosacea, is reported to have dual anti-parasitic and anti-inflammatory properties...
June 2017: Dermatology and Therapy
Kashif Siddiqui, Linda Stein Gold, Japinder Gill
BACKGROUND: Rosacea is a common chronic skin condition that manifests as recurrent inflammatory lesions. Long-term treatment is required to control symptoms and disease progression, with topical treatments being the first-line choice. Ivermectin 1 % cream is a new once-daily (QD) topical treatment for the inflammatory lesions of rosacea, and it is important to compare the efficacy, safety, and tolerability of ivermectin with other currently available topical treatments. METHODS: A systematic literature review was performed from January 2011 to June 2015, with articles published prior to 2011 retrieved from a Cochrane review on rosacea...
2016: SpringerPlus
Alain Taieb, Linda Stein Gold, Steven R Feldman, Viktor Dansk, Evelina Bertranou
BACKGROUND: Papulopustular rosacea is a chronic skin disease involving central facial erythema in combination with papules and pustules. Papulopustular rosacea is treated with topical, systemic, or a combination of topical and systemic therapies. Currently approved topical therapies include azelaic acid gel/cream/foam twice daily (BID) and metronidazole cream/gel/lotion BID. Ivermectin 1% cream once daily (QD) is a new topical agent for the treatment of papulopustular rosacea that has been approved for the management of inflammatory lesions of rosacea and offers an alternative to current treatments...
June 2016: Journal of Managed Care & Specialty Pharmacy
A Taieb, A Khemis, T Ruzicka, W Barańska-Rybak, J Berth-Jones, J Schauber, P Briantais, J Jacovella, T Passeron
BACKGROUND: There are a limited number of approved treatments for papulopustular rosacea (PPR) and remission is difficult to maintain after successful treatment. OBJECTIVES: To investigate remission over a 36-week extension period in patients with moderate to severe PPR successfully treated with 16 weeks' treatment with ivermectin 1% cream once daily (QD) or metronidazole 0.75% cream twice daily (BID) in a randomized, parallel-group Phase III study. METHODS: Treatment was discontinued in patients initially successfully treated [Investigator's Global Assessment (IGA) score of 0 or 1] with ivermectin 1% cream QD (n = 399) or metronidazole 0...
May 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
Bart J Currie
In 1991, Taplin et al. published a seminal study from Panama showing that mass drug administration of the then newly available permethrin cream dramatically reduced the high rates of endemic scabies in island communities. In this issue of the Journal, Romani and colleagues report the results of the..
December 10, 2015: New England Journal of Medicine
(no author information available yet)
Rosacea is a chronic facial skin disease that mainly occurs in people aged over 30 years. It is common, with an estimated incidence of 1·7 per 1,000 person-years in general practice in the UK.(1,2) Rosacea can cause embarrassment, anxiety, low self-esteem and lack of confidence.(3) A new topical treatment has become available for the treatment of one of the clinical subtypes of rosacea. Ivermectin 10mg/g (1%) cream (Soolantra-Galderma) has received marketing authorisation for the treatment of inflammatory lesions of papulopustular rosacea in adults...
November 2015: Drug and Therapeutics Bulletin
Emma D Deeks
Ivermectin 1% cream (Soolantra(®); Rosiver™; Izefla(®)) is a novel topical agent indicated for the once-daily treatment of inflammatory lesions of rosacea. Ivermectin is a derivative of the avermectin family of macrocyclic lactone parasiticides. It displays anti-inflammatory properties as well as broad-spectrum anti-parasitic activity, both of which may contribute to its efficacy in treating rosacea. In phase III trials of 12 or 16 weeks' duration in adults with moderate to severe papulopustular rosacea, once-daily ivermectin 1% cream improved the symptoms of rosacea (as per Investigator Global Assessment and inflammatory lesion count) and health-related quality of life versus vehicle, and was more effective than twice-daily metronidazole 0...
October 2015: American Journal of Clinical Dermatology
Pramod Kumar Manjhi, Rani Indira Sinha, Manish Kumar, Kumari Indu Sinha
BACKGROUND: The conventionally used topical antiscabetics have poor compliance. Ivermectin, an oral antiparasitic drug, has been shown to be an effective scabicide and could be a useful substitute. This study was designed to compare efficacy of oral ivermectin with commonly used topical antiscabies drugs. MATERIALS AND METHODS: This study was conducted on four groups including 60 patients in each group by simple random sampling. Treatment given in each group was: Group 1: Ivermectin (200 μg/kg body weight) oral in a single dose, Group 2: Topical Permethrin 5% cream single application, Group 3: Topical gamma benzene hexachloride (GBHC) lotion 1% single application and Group 4: Topical Benzyl benzoate (BB) lotion 25% single application...
September 2014: Journal of Clinical and Diagnostic Research: JCDR
Farah A Moustafa, Laura F Sandoval, Steven R Feldman
Rosacea is a chronic inflammatory skin condition that negatively impacts patients' quality of life. We sought to review important aspects of the pathogenesis of rosacea and the role of new treatment options in its management. New, emerging treatments show promise; however, quality randomized controlled trials for many of these drugs are lacking. Brimonidine tartrate is an effective newly approved treatment for erythematotelangiectatic rosacea. Topical oxymetazoline has potential for the treatment of erythematotelangiectatic rosacea, with efficacy described in case reports and randomized controlled trials currently underway...
September 2014: Drugs
Louise S Deeks, Mark Naunton, Marian J Currie, Francis J Bowden
OBJECTIVE: To investigate the pharmacology, pharmacokinetics, efficacy, adverse effects, and place in therapy of a single application of topical ivermectin 0.5% lotion for head lice treatment. DATA SOURCES: Literature was obtained by searching MEDLINE, PubMed, CINAHL, and Scopus (January 1980 to January 2013). Abstracts were searched for the terms ivermectin AND (head lice or pediculus or pediculosis), topical ivermectin, ivermectin lotion, ivermectin AND (pharmacology OR pharmacokinetics)...
September 2013: Annals of Pharmacotherapy
Mohamad Goldust, Elham Rezaee, Ramin Raghifar, Sevil Hemayat
Human scabies is caused by an infestation of the skin by the human itch mite (Sarcoptes scabiei va. hominis). It is commonly treated with topical insecticides, but the treatment of choice is still controversial. The aim of this study is to compare the efficacy of topical ivermectin vs. permethrin 2.5% cream for the treatment of scabies. In total, 380 patients with scabies were enrolled, and randomized into two groups: the first group received 1% ivermectin applied topically to the affected skin at a dose of 400 microg/kg, repeated once the following week, while the second group received permethrin 2...
2013: Annals of Parasitology
A Mohebbipour, P Saleh, M Goldust, M Amirnia, Y J Zadeh, R M Mohamad, E Rezaee
BACKGROUND: Scabies is a common parasitic infestation that is an important public-health problem in many resource-poor regions. It is commonly treated with the insecticides ivermectin and permethrin. AIM: To compare the efficacy and safety of oral ivermectin vs. lindane lotion 1% for the treatment of scabies. METHODS: In total, 148 patients with scabies were enrolled, and were randomized into two groups: the first group received a single dose of oral ivermectin 200 μg/kg body weight, and the second group were treated with two applications of topical lindane lotion 1%, with a 1-week interval between applications...
October 2013: Clinical and Experimental Dermatology
Sunita B Chhaiya, Varsha J Patel, Jayendra N Dave, Dimple S Mehta, Hiral A Shah
BACKGROUND: Ivermectin has opened a new era in the management of scabies as orally effective drug. However, topical route has been little explored for ivermectin. AIMS: To compare the efficacy and safety of topical permethrin, oral ivermectin, and topical ivermectin in the treatment of uncomplicated scabies. METHODS: This was an open-label, randomized, comparative, parallel clinical trial conducted in 315 patients, randomly allocated to 3 groups...
September 2012: Indian Journal of Dermatology, Venereology and Leprology
Johanna Stoevesandt, Lydia Carlé, Martin Leverkus, Henning Hamm
BACKGROUND: Scabies outbreaks in community facilities may reach large dimensions and take a protracted course. Highly contagious crusted scabies is a major cause of nosocomial outbreaks. PATIENTS AND METHODS: On the occasion of an extensive scabies outbreak in a north Bavarian sheltered workshop and its associated residential homes with over 500 exposed individuals, a multifaceted control strategy was developed and pursued. Knowledge from a comprehensive review of the literature was utilized...
September 2012: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
Mohamad Goldust, Elham Rezaee, Sevil Hemayat
Scabies is an ectoparasitic, highly contagious skin disease caused by a mite called Sarcoptes scabiei. The insecticides ivermectin and permethrin are commonly used for treatment of scabies. This study aimed at comparing the efficacy of oral ivermectin with topical permethrin in treating scabies. Two hundred and forty-two patients with scabies attending the dermatology outpatient department of Sina Hospital, Tabriz University of Medical Sciences were admitted. Patients were divided into two groups randomly. The first group and their family contacts received 5% permethrin cream and the other received oral ivermectin...
June 2012: Journal of Dermatology
Shusheng Tang, Linlin Chen, Zhaoxu Guo, Xiuzhi Hu, Jiakang He, Gang Wang, Tingting Zhao, Xilong Xiao
A new oil suspension containing 0.15% ivermectin and 15% praziquantel for intramuscular injection was developed, and corresponding pharmacokinetics studies were conducted in swine. The combination product is a white- to cream-colored oil suspension and its physical properties such as settling volume ratio, redispersibility, syringeability and flowability are well consistent with the Technical Standards by the Ministry of Agriculture of the People's Republic of China. The pharmacokinetic study consists of two parts...
April 30, 2012: Veterinary Parasitology
Abdulghani Mohamad Alsamarai
BACKGROUND: The burden of scabies is highest in tropical countries, but recent data from Iraq are scanty. OBJECTIVE: To estimate the frequency of scabies in patients of a dermatology clinic in central Iraq. METHODOLOGY: The study was conducted in Tikrit (Iraq), between May 2007 and February 2008. A total of 1,194 patients presenting to a dermatology clinic were included in the study. RESULTS: During the study period, 132 [1...
2009: Journal of Infection in Developing Countries
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