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Ivermectin 1% cream

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https://www.readbyqxmd.com/read/27504249/the-efficacy-safety-and-tolerability-of-ivermectin-compared-with-current-topical-treatments-for-the-inflammatory-lesions-of-rosacea-a-network-meta-analysis
#1
Kashif Siddiqui, Linda Stein Gold, Japinder Gill
BACKGROUND: Rosacea is a common chronic skin condition that manifests as recurrent inflammatory lesions. Long-term treatment is required to control symptoms and disease progression, with topical treatments being the first-line choice. Ivermectin 1 % cream is a new once-daily (QD) topical treatment for the inflammatory lesions of rosacea, and it is important to compare the efficacy, safety, and tolerability of ivermectin with other currently available topical treatments. METHODS: A systematic literature review was performed from January 2011 to June 2015, with articles published prior to 2011 retrieved from a Cochrane review on rosacea...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27231793/cost-effectiveness-of-ivermectin-1-cream-in-adults-with-papulopustular-rosacea-in-the-united-states
#2
Alain Taieb, Linda Stein Gold, Steven R Feldman, Viktor Dansk, Evelina Bertranou
BACKGROUND: Papulopustular rosacea is a chronic skin disease involving central facial erythema in combination with papules and pustules. Papulopustular rosacea is treated with topical, systemic, or a combination of topical and systemic therapies. Currently approved topical therapies include azelaic acid gel/cream/foam twice daily (BID) and metronidazole cream/gel/lotion BID. Ivermectin 1% cream once daily (QD) is a new topical agent for the treatment of papulopustular rosacea that has been approved for the management of inflammatory lesions of rosacea and offers an alternative to current treatments...
June 2016: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/26691278/maintenance-of-remission-following-successful-treatment-of-papulopustular-rosacea-with-ivermectin-1-cream-vs-metronidazole-0-75-cream-36-week-extension-of-the-attract-randomized-study
#3
A Taieb, A Khemis, T Ruzicka, W Barańska-Rybak, J Berth-Jones, J Schauber, P Briantais, J Jacovella, T Passeron
BACKGROUND: There are a limited number of approved treatments for papulopustular rosacea (PPR) and remission is difficult to maintain after successful treatment. OBJECTIVES: To investigate remission over a 36-week extension period in patients with moderate to severe PPR successfully treated with 16 weeks' treatment with ivermectin 1% cream once daily (QD) or metronidazole 0.75% cream twice daily (BID) in a randomized, parallel-group Phase III study. METHODS: Treatment was discontinued in patients initially successfully treated [Investigator's Global Assessment (IGA) score of 0 or 1] with ivermectin 1% cream QD (n = 399) or metronidazole 0...
May 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/26650157/scabies-and-global-control-of-neglected-tropical-diseases
#4
EDITORIAL
Bart J Currie
In 1991, Taplin et al. published a seminal study from Panama showing that mass drug administration of the then newly available permethrin cream dramatically reduced the high rates of endemic scabies in island communities. In this issue of the Journal, Romani and colleagues report the results of the..
December 10, 2015: New England Journal of Medicine
https://www.readbyqxmd.com/read/26563877/ivermectin-cream-for-rosacea
#5
(no author information available yet)
Rosacea is a chronic facial skin disease that mainly occurs in people aged over 30 years. It is common, with an estimated incidence of 1·7 per 1,000 person-years in general practice in the UK.(1,2) Rosacea can cause embarrassment, anxiety, low self-esteem and lack of confidence.(3) A new topical treatment has become available for the treatment of one of the clinical subtypes of rosacea. Ivermectin 10mg/g (1%) cream (Soolantra-Galderma) has received marketing authorisation for the treatment of inflammatory lesions of papulopustular rosacea in adults...
November 2015: Drug and Therapeutics Bulletin
https://www.readbyqxmd.com/read/26254001/ivermectin-a-review-in-rosacea
#6
REVIEW
Emma D Deeks
Ivermectin 1% cream (Soolantra(®); Rosiver™; Izefla(®)) is a novel topical agent indicated for the once-daily treatment of inflammatory lesions of rosacea. Ivermectin is a derivative of the avermectin family of macrocyclic lactone parasiticides. It displays anti-inflammatory properties as well as broad-spectrum anti-parasitic activity, both of which may contribute to its efficacy in treating rosacea. In phase III trials of 12 or 16 weeks' duration in adults with moderate to severe papulopustular rosacea, once-daily ivermectin 1% cream improved the symptoms of rosacea (as per Investigator Global Assessment and inflammatory lesion count) and health-related quality of life versus vehicle, and was more effective than twice-daily metronidazole 0...
October 2015: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/25386453/comparative-study-of-efficacy-of-oral-ivermectin-versus-some-topical-antiscabies-drugs-in-the-treatment-of-scabies
#7
Pramod Kumar Manjhi, Rani Indira Sinha, Manish Kumar, Kumari Indu Sinha
BACKGROUND: The conventionally used topical antiscabetics have poor compliance. Ivermectin, an oral antiparasitic drug, has been shown to be an effective scabicide and could be a useful substitute. This study was designed to compare efficacy of oral ivermectin with commonly used topical antiscabies drugs. MATERIALS AND METHODS: This study was conducted on four groups including 60 patients in each group by simple random sampling. Treatment given in each group was: Group 1: Ivermectin (200 μg/kg body weight) oral in a single dose, Group 2: Topical Permethrin 5% cream single application, Group 3: Topical gamma benzene hexachloride (GBHC) lotion 1% single application and Group 4: Topical Benzyl benzoate (BB) lotion 25% single application...
September 2014: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/25154627/rosacea-new-and-emerging-treatments
#8
REVIEW
Farah A Moustafa, Laura F Sandoval, Steven R Feldman
Rosacea is a chronic inflammatory skin condition that negatively impacts patients' quality of life. We sought to review important aspects of the pathogenesis of rosacea and the role of new treatment options in its management. New, emerging treatments show promise; however, quality randomized controlled trials for many of these drugs are lacking. Brimonidine tartrate is an effective newly approved treatment for erythematotelangiectatic rosacea. Topical oxymetazoline has potential for the treatment of erythematotelangiectatic rosacea, with efficacy described in case reports and randomized controlled trials currently underway...
September 2014: Drugs
https://www.readbyqxmd.com/read/24259731/topical-ivermectin-0-5-lotion-for-treatment-of-head-lice
#9
REVIEW
Louise S Deeks, Mark Naunton, Marian J Currie, Francis J Bowden
OBJECTIVE: To investigate the pharmacology, pharmacokinetics, efficacy, adverse effects, and place in therapy of a single application of topical ivermectin 0.5% lotion for head lice treatment. DATA SOURCES: Literature was obtained by searching MEDLINE, PubMed, CINAHL, and Scopus (January 1980 to January 2013). Abstracts were searched for the terms ivermectin AND (head lice or pediculus or pediculosis), topical ivermectin, ivermectin lotion, ivermectin AND (pharmacology OR pharmacokinetics)...
September 2013: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/24171301/treatment-of-scabies-the-topical-ivermectin-vs-permethrin-2-5-cream
#10
RANDOMIZED CONTROLLED TRIAL
Mohamad Goldust, Elham Rezaee, Ramin Raghifar, Sevil Hemayat
Human scabies is caused by an infestation of the skin by the human itch mite (Sarcoptes scabiei va. hominis). It is commonly treated with topical insecticides, but the treatment of choice is still controversial. The aim of this study is to compare the efficacy of topical ivermectin vs. permethrin 2.5% cream for the treatment of scabies. In total, 380 patients with scabies were enrolled, and randomized into two groups: the first group received 1% ivermectin applied topically to the affected skin at a dose of 400 microg/kg, repeated once the following week, while the second group received permethrin 2...
2013: Annals of Parasitology
https://www.readbyqxmd.com/read/23772999/comparison-of-oral-ivermectin-vs-lindane-lotion-1-for-the-treatment-of-scabies
#11
RANDOMIZED CONTROLLED TRIAL
A Mohebbipour, P Saleh, M Goldust, M Amirnia, Y J Zadeh, R M Mohamad, E Rezaee
BACKGROUND: Scabies is a common parasitic infestation that is an important public-health problem in many resource-poor regions. It is commonly treated with the insecticides ivermectin and permethrin. AIM: To compare the efficacy and safety of oral ivermectin vs. lindane lotion 1% for the treatment of scabies. METHODS: In total, 148 patients with scabies were enrolled, and were randomized into two groups: the first group received a single dose of oral ivermectin 200 μg/kg body weight, and the second group were treated with two applications of topical lindane lotion 1%, with a 1-week interval between applications...
October 2013: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/22960817/comparative-efficacy-and-safety-of-topical-permethrin-topical-ivermectin-and-oral-ivermectin-in-patients-of-uncomplicated-scabies
#12
RANDOMIZED CONTROLLED TRIAL
Sunita B Chhaiya, Varsha J Patel, Jayendra N Dave, Dimple S Mehta, Hiral A Shah
BACKGROUND: Ivermectin has opened a new era in the management of scabies as orally effective drug. However, topical route has been little explored for ivermectin. AIMS: To compare the efficacy and safety of topical permethrin, oral ivermectin, and topical ivermectin in the treatment of uncomplicated scabies. METHODS: This was an open-label, randomized, comparative, parallel clinical trial conducted in 315 patients, randomly allocated to 3 groups...
September 2012: Indian Journal of Dermatology, Venereology and Leprology
https://www.readbyqxmd.com/read/22458610/control-of-large-institutional-scabies-outbreaks
#13
Johanna Stoevesandt, Lydia Carlé, Martin Leverkus, Henning Hamm
BACKGROUND: Scabies outbreaks in community facilities may reach large dimensions and take a protracted course. Highly contagious crusted scabies is a major cause of nosocomial outbreaks. PATIENTS AND METHODS: On the occasion of an extensive scabies outbreak in a north Bavarian sheltered workshop and its associated residential homes with over 500 exposed individuals, a multifaceted control strategy was developed and pursued. Knowledge from a comprehensive review of the literature was utilized...
September 2012: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/22385121/treatment-of-scabies-comparison-of-permethrin-5-versus-ivermectin
#14
RANDOMIZED CONTROLLED TRIAL
Mohamad Goldust, Elham Rezaee, Sevil Hemayat
Scabies is an ectoparasitic, highly contagious skin disease caused by a mite called Sarcoptes scabiei. The insecticides ivermectin and permethrin are commonly used for treatment of scabies. This study aimed at comparing the efficacy of oral ivermectin with topical permethrin in treating scabies. Two hundred and forty-two patients with scabies attending the dermatology outpatient department of Sina Hospital, Tabriz University of Medical Sciences were admitted. Patients were divided into two groups randomly. The first group and their family contacts received 5% permethrin cream and the other received oral ivermectin...
June 2012: Journal of Dermatology
https://www.readbyqxmd.com/read/22075041/pharmacokinetics-of-a-new-ivermectin-praziquantel-oil-suspension-after-intramuscular-administration-in-pigs
#15
RANDOMIZED CONTROLLED TRIAL
Shusheng Tang, Linlin Chen, Zhaoxu Guo, Xiuzhi Hu, Jiakang He, Gang Wang, Tingting Zhao, Xilong Xiao
A new oil suspension containing 0.15% ivermectin and 15% praziquantel for intramuscular injection was developed, and corresponding pharmacokinetics studies were conducted in swine. The combination product is a white- to cream-colored oil suspension and its physical properties such as settling volume ratio, redispersibility, syringeability and flowability are well consistent with the Technical Standards by the Ministry of Agriculture of the People's Republic of China. The pharmacokinetic study consists of two parts...
April 30, 2012: Veterinary Parasitology
https://www.readbyqxmd.com/read/20009281/frequency-of-scabies-in-iraq-survey-in-a-dermatology-clinic
#16
Abdulghani Mohamad Alsamarai
BACKGROUND: The burden of scabies is highest in tropical countries, but recent data from Iraq are scanty. OBJECTIVE: To estimate the frequency of scabies in patients of a dermatology clinic in central Iraq. METHODOLOGY: The study was conducted in Tikrit (Iraq), between May 2007 and February 2008. A total of 1,194 patients presenting to a dermatology clinic were included in the study. RESULTS: During the study period, 132 [1...
2009: Journal of Infection in Developing Countries
https://www.readbyqxmd.com/read/19936297/a-regional-initiative-to-reduce-skin-infections-amongst-aboriginal-children-living-in-remote-communities-of-the-northern-territory-australia
#17
Ross M Andrews, Therese Kearns, Christine Connors, Colin Parker, Kylie Carville, Bart J Currie, Jonathan R Carapetis
BACKGROUND: Linked to extreme rates of chronic heart and kidney disease, pyoderma is endemic amongst Aboriginal children in Australia's Northern Territory (NT). Many of those with pyoderma will also have scabies. We report the results of a community-based collaboration within the East Arnhem Region, which aimed to reduce the prevalence of both skin infections in Aboriginal children. METHODOLOGY/PRINCIPAL FINDINGS: Commencing September 2004, we conducted an ecological study that included active surveillance for skin infections amongst children aged <15 years in five remote East Arnhem communities over a three year period...
November 24, 2009: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/18561612/demodex-folliculorum-and-demodex-brevis-as-a-cause-of-chronic-marginal-blepharitis
#18
REVIEW
Damian Czepita, Wanda Kuźna-Grygiel, Maciej Czepita, Andrzej Grobelny
INTRODUCTION: Intensive long-term studies of Demodex spp. (D.) and its role in chronic blepharits have been carried out in recent years by scientists from the Pomeranian Medical University in Szczecin. It has resulted in numerous publications, spurring a lot of interest worldwide. A few of the papers have been cited in leading American medical journals. In recent years many papers dealing with demodicosis of the eyelids have been published worldwide. Based on the growing interest in the role of Demodex spp...
2007: Annales Academiae Medicae Stetinensis
https://www.readbyqxmd.com/read/18361540/scabies-outbreaks-in-nursing-homes-for-the-elderly-recognition-treatment-options-and-control-of-reinfestation
#19
REVIEW
Milan Tjioe, Wynand H P M Vissers
The scabies mite is an ectoparasite able to infest humans. Its clinical presentation is typical, although in immunocompromised, mentally retarded and elderly patients the clinical presentation may be altered. Diagnosis may therefore be difficult in such patient groups, who often reside in nursing homes. Because delay in diagnosis may induce rapid spread of the scabies mite, immediate diagnosis and treatment are necessary. Normal scabies (scabies vulgaris) and crusted scabies (scabies crustosa, scabies norvegica), although sometimes difficult to diagnose, especially in the elderly, are fortunately quite easy to treat...
2008: Drugs & Aging
https://www.readbyqxmd.com/read/17483659/diagnostic-dilemma-crusted-scabies-superimposed-on-psoriatic-erythroderma-in-a-patient-with-acquired-immunodeficiency-syndrome
#20
Brian S Fuchs, Allen N Sapadin, Robert G Phelps, Donald Rudikoff
A 45-year-old man with AIDS presented with extensive erythema and scaling involving the face, trunk, and upper and lower extremities, and mild nail dystrophy. The patient had been diagnosed with psoriasis 2 years previously, and at the time of presentation was using emollients and topical corticosteroid creams with little improvement. He was receiving zidovudine, lamivudine, trimethoprim/sulfamethoxazole, acyclovir, rifabutin, and hydroxyzine. Pertinent laboratory data included CD4 lymphocytes (10 cells/mm(3)), viral load (32,000 copies per mL) white blood cell count (3...
May 2007: Skinmed
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