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https://www.readbyqxmd.com/read/29340835/repurposed-fda-approved-drugs-targeting-genes-influencing-aging-can-extend-lifespan-and-healthspan-in-rotifers
#1
Terry W Snell, Rachel K Johnston, Amelia B Matthews, Hongyi Zhou, Mu Gao, Jeffrey Skolnick
Pharmaceutical interventions can slow aging in animals, and have advantages because their dose can be tightly regulated and the timing of the intervention can be closely controlled. They also may complement environmental interventions like caloric restriction by acting additively. A fertile source for therapies slowing aging is FDA approved drugs whose safety has been investigated. Because drugs bind to several protein targets, they cause multiple effects, many of which have not been characterized. It is possible that some of the side effects of drugs prescribed for one therapy may have benefits in retarding aging...
January 16, 2018: Biogerontology
https://www.readbyqxmd.com/read/29329623/parasite-control-strategies-used-by-equine-owners-in-the-united-states-a-national-survey
#2
M K Nielsen, M A Branan, A M Wiedenheft, R Digianantonio, L P Garber, C A Kopral, A M Phillippi-Taylor, J L Traub-Dargatz
The widespread occurrence of anthelmintic resistance in equine parasites across the world has led to recommendations of fecal egg count-based parasite programs to reduce treatment intensity and thereby delay further development of resistance as much as possible. The most recent study describing equine parasite control in the United States was conducted 20 years ago, and little is known about current strategies employed. This study was part of the National Animal Health Monitoring Systems (NAHMS) Equine 2015 Study, and aimed to describe equine parasite control strategies in the U...
January 30, 2018: Veterinary Parasitology
https://www.readbyqxmd.com/read/29329620/determination-and-validation-of-discriminating-concentration-of-ivermectin-against-rhipicephalus-microplus
#3
Abhijit Nandi, Sharath V Sagar, Gajanan Chigure, Ashutosh Fular, Anil Kumar Sharma, Gaurav Nagar, Sachin Kumar, B C Saravanan, Srikant Ghosh
Rhipicephalus microplus, the major cattle tick species of India is prevalent all over the country and causes huge economic loss directly or indirectly to the dairy industries. Chemical acaricides are playing an important role in managing tick infestations on livestock for many years and consequently, resistance to commonly used organophosphate (OP) and synthetic pyrethroid (SP) compounds has been reported. Subsequently, ivermectin (IVM) has been emerged as an alternative to manage OP and SP resistant ticks...
January 30, 2018: Veterinary Parasitology
https://www.readbyqxmd.com/read/29322297/nuclear-distribution-of-the-trypanosoma-cruzi-rna-pol-i-subunit-rpa31-during-growth-and-metacyclogenesis-and-characterization-of-its-nuclear-localization-signal
#4
Israel Canela-Pérez, Imelda López-Villaseñor, Ana María Cevallos, Roberto Hernández
Trypanosoma cruzi is the aetiologic agent of Chagas disease. Our research group studies ribosomal RNA (rRNA) gene transcription and nucleolus dynamics in this species of trypanosomes. RPA31 is an essential subunit of RNA polymerase I (Pol I) whose presence is apparently restricted to trypanosomes. Using fluorescent-tagged versions of this protein (TcRPA31-EGFP), we describe its nuclear distribution during growth and metacyclogenesis. Our findings indicate that TcRPA31-EGFP alters its nuclear presence from concentrated nucleolar localization in exponentially growing epimastigotes to a dispersed granular distribution in the nucleoplasm of stationary epimastigotes and metacyclic trypomastigotes...
January 10, 2018: Parasitology Research
https://www.readbyqxmd.com/read/29321677/recognition-by-host-nuclear-transport-proteins-drives-disorder-to-order-transition-in-hendra-virus-v
#5
Sarah C Atkinson, Michelle D Audsley, Kim G Lieu, Glenn A Marsh, David R Thomas, Steven M Heaton, Jason J Paxman, Kylie M Wagstaff, Ashley M Buckle, Gregory W Moseley, David A Jans, Natalie A Borg
Hendra virus (HeV) is a paramyxovirus that causes lethal disease in humans, for which no vaccine or antiviral agent is available. HeV V protein is central to pathogenesis through its ability to interact with cytoplasmic host proteins, playing key antiviral roles. Here we use immunoprecipitation, siRNA knockdown and confocal laser scanning microscopy to show that HeV V shuttles to and from the nucleus through specific host nuclear transporters. Spectroscopic and small angle X-ray scattering studies reveal HeV V undergoes a disorder-to-order transition upon binding to either importin α/β1 or exportin-1/Ran-GTP, dependent on the V N-terminus...
January 10, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29313486/phase-iii-clinical-trial-to-evaluate-ivermectin-in-the-reduction-of-mansonella-ozzardi-infection-in-the-brazilian-amazon
#6
Sergio de Almeida Basano, Juliana Souza de Almeida Aranha Camargo, Gilberto Fontes, Antonieta Relvas Pereira, Jansen Fernandes Medeiros, Mayara Costa de Oliveira Laudisse, Ricardo de Godoi Mattos Ferreira, Luís Marcelo Aranha Camargo
The treatment of mansonelliasis is still a challenge because there are few clinical trials for the treatment of the disease. This double-blind, randomized, placebo-controlled study (phase III clinical trial) was conducted to evaluate the effectiveness of a single oral dose of ivermectin (0.15 mg/kg) in the reduction of the Mansonella ozzardi microfilaraemia and the occurrence of adverse effects in infected people compared with the control group treated with placebo. A total of 49 microfilaraemic patients were randomly selected from the municipality of Lábrea, State of Amazonas, in the Brazilian Amazon...
January 8, 2018: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29296196/antitumor-effects-of-the-antiparasitic-agent-ivermectin-via-inhibition-of-yes-associated-protein-1-expression-in-gastric-cancer
#7
Sho Nambara, Takaaki Masuda, Miki Nishio, Shotaro Kuramitsu, Taro Tobo, Yushi Ogawa, Qingjiang Hu, Tomohiro Iguchi, Yousuke Kuroda, Shuhei Ito, Hidetoshi Eguchi, Keishi Sugimachi, Hiroshi Saeki, Eiji Oki, Yoshihiko Maehara, Akira Suzuki, Koshi Mimori
Yes-associated protein 1 (YAP1) acts as an oncogene through dephosphorylation and nuclear translocation, and nuclear accumulation of YAP1 is associated with poor prognosis in gastric cancer (GC). We previously identified ivermectin, an antiparasitic drug, as a YAP1 inhibitor. Here, we aimed to clarify whether ivermectin had antitumor effects on GC through inhibition of YAP1. First, we evaluated the antiproliferative effects of ivermectin on human GC cells using in vitro proliferation assays and a xenograft mouse model...
December 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/29289559/geographical-distribution-and-species-identification-of-human-filariasis-and-onchocerciasis-in-bioko-island-equatorial-guinea
#8
Thuy-Huong Ta, Laura Moya, Justino Nguema, Pilar Aparicio, María Miguel Oteo, Gema Cenzual, Isabel Canorea, Marta Lanza, Agustín Benito, James Lee Crainey, José Miguel Rubio
Human filariae are vector-borne parasites and the causative agents of various diseases, including human onchocerciasis and lymphatic filariasis. Onchocerciasis causes a spectrum of cutaneous and ophthalmologic manifestations (including blindness) and has long been a major public health problem in Bioko Island (Equatorial Guinea). Bioko Island has been included in the WHO's Onchocerciasis Control Program since 1987. In Bioko Island, the specificity and sensitivity of clinical Onchocerca volvulus diagnosis is key...
December 28, 2017: Acta Tropica
https://www.readbyqxmd.com/read/29288959/ivermectin-acute-administration-impaired-the-spermatogenesis-and-spermiogenesis-of-adult-rats
#9
Flora Cordeiro, Vagner Gonçalves, Natalia Moreira, João Iosif Slobodticov, Nathalia de Andrade Galvão, Helenice de Souza Spinosa, Leoni Villano Bonamin, Eduardo Fernandes Bondan, Claudia Helena Pastor Ciscato, Cláudia Maria Barbosa, Maria Martha Bernardi
Ivermectin (IVM) is an antiparasitic agent widely used in agricultural, domestic animals and in human clinical practice. In the present study, the temporal effects of therapeutic doses of IVM in the morphometric and histological assessment of testis were studied to verify if IVM acute administration impaired the spermatogenesis and spermiogenesis of adult rats, if these effects are reversible. The testosterone levels and the plasmatic IVM levels were assessed. The results show: 1) IVM acute exposure, mainly in the higher dose, reduced the testicular volume, the tubular diameter and the germinal epithelium height; 2) no interferences on Leydig cells frequency; 3) histological studies show that tubular sections containing several histological changes indicative of spermatogenesis interruption, such as disorganization of germinal epithelium, vacuolar degeneration of the germ cells and sloughing of cells into the tubular lumen; 4) no differences in testosterone levels; 5) The IVM plasmatic levels were significantly reduced at 72h after the 0...
December 18, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/29286021/toenail-onychomycosis-by-trichophyton-rubrum-and-concurrent-infestation-with-tyrophagus-putrescentiae
#10
Valentina Fabrizi, Ivana Zacconi, Mario Principato, Cristina Pesca, Deborah Cruciani, Silvia Crotti, Manuela Papini
A remarkable case of onychomycosis by Trichophyton (T.) rubrum combined with nail infestation by Tyrophagus (T.) putrescentiae in an elderly diabetic farmer is described and discussed. Large numbers of eggs and mites in all development stages were present in nail debris, reflecting active reproduction on site. Treatment with ivermectin 0.1% cream and environmental decontamination cleared the mite infestation, while onychomycosis responded well to oral terbinafine and ciclopirox 8% nail lacquer. Such a combination of onychomycosis and mite infestation of the same nail is an exceptional finding reported only twice in the literature...
December 1, 2017: Le Infezioni in Medicina
https://www.readbyqxmd.com/read/29283560/targeted-drug-delivery-and-treatment-of-endoparasites-with-biocompatible-particles-of-ph-responsive-structure
#11
Patrick D Mathews, Ana Carolina Monge Fernandes Patta, Joao Vitor Gonçalves, Gabriella Dos Santos Gama, Irene Teresinha Santos Garcia, Omar Mertins
Biomaterials conceived for vectorization of bioactives are currently considered for biomedical, biological and environmental applications. We have produced a pH sensitive biomaterial composed of natural source alginate and chitosan polysaccharides for application as drug delivery system via oral administration. The composite particles preparation was in situ monitored by means of isothermal titration calorimetry. The strong interaction established between the macromolecules during particles assembling lead to 0...
December 28, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/29282130/what-does-not-kill-it-makes-it-weaker-effects-of-sub-lethal-concentrations-of-ivermectin-on-the-locomotor-activity-of-anopheles-aquasalis
#12
Vanderson de Souza Sampaio, Gustavo Bueno da Silva Rivas, Kevin Kobylinski, Yudi Tatiana Pinilla, Paulo Filemon Paolluci Pimenta, José Bento Pereira Lima, Rafaela Vieira Bruno, Marcus Vinícius Guimarães Lacerda, Wuelton Marcelo Monteiro
BACKGROUND: Malaria remains a major public health concern. Vector control measures based solely on insecticide treated nets (ITNs) and indoor residual spraying (IRS) have demonstrated not to be feasible for malaria elimination. It has been shown that ivermectin affects several aspects of Anopheles species biology. Along the Latin American seacoast, Anopheles aquasalis Curry plays an important role in malaria transmission. The observation of mosquitoes locomotor activity under laboratory conditions can reveal details of their daily activity rhythms, which is controlled by an endogenous circadian clock that seems to be influenced by external signals, such as light and temperature...
December 28, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/29279092/weight-gain-and-resistance-to-gastrointestinal-nematode-infections-in-two-genetically-diverse-groups-of-cattle
#13
Johan Höglund, Anna Hessle, Konstantinos Zaralis, Katarina Arvidsson-Segerkvist, Spiridoula Athanasiadou
Body weight gain (BWG) and gastrointestinal nematode challenge (GIN) were investigated in two genetically diverse groups of cattle. Thirty-two dairy calves (D=Swedish Red/Holstein) and 31 dairy×beef crosses (C=Swedish Red/Holstein×Charolais) pairwise matched by dam breed and birth dates, were monitored for ≈20 weeks on a pasture grazed by cattle in the previous year. At turn-out, animals (between 6 and 12 months age) from each genotype were either infected with 5000 third stage (L3) Ostertagia ostertagi (50%) and Cooperia oncophora (50%) larvae (H, high-exposure); or treated monthly with 0...
January 15, 2018: Veterinary Parasitology
https://www.readbyqxmd.com/read/29277087/in-vivo-confocal-microscopy-for-detection-of-subconjunctival-onchocerca-lupi-infection-in-a-dog
#14
Michele L Edelmann, Mason Jager, Filipe Espinheira, Eric C Ledbetter
A seven-year-old male castrated mixed-breed dog was diagnosed with bilateral subconjunctival masses. In vivo confocal microscopy facilitated visualization of Onchocerca lupi adult nematodes and their characteristic cuticular morphology. Long, thin, white nematodes were extracted during excisional biopsy. Histopathologic and parasitologic evaluation confirmed the diagnosis of O. lupi. In addition to surgical debulking of the parasitic granulomas, the dog received systemic doxycycline, prednisone, and ivermectin therapy...
December 25, 2017: Veterinary Ophthalmology
https://www.readbyqxmd.com/read/29275076/dermatological-manifestations-in-onchocerciasis-a-retrospective-study-of-400-imported-cases
#15
Sabino Puente, German Ramirez-Olivencia, Mar Lago, Mercedes Subirats, Eugenio Perez-Blazquez, Fernando Bru, Teresa Garate, Belén Vicente, Moncef Belhassen-Garcia, Antonio Muro
INTRODUCTION: Onchocerciasis is caused by Onchocerca volvulus and mainly leads to pruritus and skin and visual disorders, including blindness. Seventeen million people are infected in 38 countries; 31 of these are in sub-Saharan Africa, six in Latin America and one on the Arabian Peninsula. More than 99% of cases occur in sub-Saharan Africa where 120 million people are at risk of infection. Eye disorders have been well-documented; however, skin disorders have not been described accurately...
December 20, 2017: Enfermedades Infecciosas y Microbiología Clínica
https://www.readbyqxmd.com/read/29274827/motility-in-the-l3-stage-is-a-poor-phenotype-for-detecting-and-measuring-resistance-to-avermectin-milbemycin-drugs-in-gastrointestinal-nematodes-of-livestock
#16
Melissa M George, Lorraine Lopez-Soberal, Bob E Storey, Sue B Howell, Ray M Kaplan
Motility is a commonly used in vitro phenotype for assessing anthelmintic activity of candidate compounds, and for detecting anthelmintic resistance in nematodes. Third-stage larvae (L3) of parasitic nematodes are commonly used in motility-based assays because L3 are simple to obtain and can remain viable in storage for extended periods. To improve the measurement of motility of microscopic stages of nematodes, our laboratory developed the Worminator, which quantitatively measures motility of parasites. Using the Worminator, we compared the dose-response characteristics of several avermectin/milbemycin (AM) compounds using L3 from both AM-susceptible and AM-resistant Cooperia spp...
December 18, 2017: International Journal for Parasitology, Drugs and Drug Resistance
https://www.readbyqxmd.com/read/29274052/epidemiology-and-effect-of-gastrointestinal-nematodes-on-beef-cattle-from-tropical-argentina
#17
V H Suarez, G M Martínez, J F Micheloud, A E Viñabal
The aim of this work was to study the epidemiology and the harmful effect of gastrointestinal nematodes (GINs) on beef cattle in the piedmont forest and grassland region of northwestern Argentina, between March 2015 and March 2016. Sixty weaned female calves were divided into three groups: STG-calves treated systematically with 200 mcg/kg moxidectin every 40-50 days; LTG-calves treated as usually locally implemented, with 200 mcg/kg ivermectin on May 4 and August 5; and UTG-calves not receiving treatment...
December 22, 2017: Tropical Animal Health and Production
https://www.readbyqxmd.com/read/29251394/optic-neuritis-in-dogs-96-cases-1983-2016
#18
Sara M Smith, Hans D Westermeyer, Christopher L Mariani, Brian C Gilger, Michael G Davidson
OBJECTIVE: To characterize ocular and neurologic findings, causes, and treatment outcomes of dogs with optic neuritis. PROCEDURE: Medical records from dogs with a diagnosis of optic neuritis at North Carolina State University, College of Veterinary Medicine, Veterinary Hospital between 1983 and 2016 were reviewed. RESULTS: Ninety-six cases (20 unilateral, 76 bilateral), comprised of 38 males and 58 females with a mean age of 6.1 ± 3.0 years (range 0...
December 18, 2017: Veterinary Ophthalmology
https://www.readbyqxmd.com/read/29249250/-what-s-new-in-pediatric-dermatology
#19
C Chiaverini
The year 2017 in pediatric dermatology was marked by several consensus recommendations and meta analyzes on childhood psoriasis, atopic dermatitis or PHACE syndrome, case series on the role of anti-JAK treatment in adolescent with alopecia areata, sirolimus for vascular malformations, ivermectine for rosacea, inhibitors of MEK for type 1 neurofibromatosis or on the side effects of the oral isotretinoin for acne or propranolol for immature hemangioma. Only few randomized controlled studies have been published on the interest of adalimumab in the treatment of psoriasis or topical sirolimus for angiofibroma in tuberous sclerosis complex for example...
December 2017: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/29241784/ivermectin-versus-permethrin-in-the-treatment-of-scabies-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#20
Ashar Dhana, Hsi Yen, Jean-Phillip Okhovat, Eunyoung Cho, NaNa Keum, Nonhlanhla P Khumalo
No abstract text is available yet for this article.
January 2018: Journal of the American Academy of Dermatology
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