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https://www.readbyqxmd.com/read/28639722/european-guideline-for-the-management-of-scabies
#1
C M Salavastru, O Chosidow, M J Boffa, M Janier, G S Tiplica
Scabies is caused by Sarcoptes scabiei var. hominis. The disease can be sexually transmitted. Patients' main complaint is nocturnal itch. Disseminated, excoriated, erythematous papules are usually seen on the anterior trunk and limbs. Crusted scabies occurs in immunocompromised hosts and may be associated with reduced or absent pruritus. Recommended treatments are permethrin 5% cream, oral ivermectin and benzyl benzoate 25% lotion. Alternative treatments are malathion 0.5% aqueous lotion, ivermectin 1% lotion and sulphur 6-33% cream, ointment or lotion...
June 22, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28624508/epidemiological-profile-of-cutaneous-larva-migrans-in-travelers-returning-to-france-between-2003-and-2015
#2
Doudou Sow, Ferelaha Soro, Emilie Javelle, Fabrice Simon, Philippe Parola, Philippe Gautret
BACKGROUND: Cutaneous larva migrans (CLM) is caused by the penetration and migration of canine or feline hookworm larvae into the skin, and frequently affects travelers from high-income countries returning from tropical and sub-tropical areas. Unfortunately, this pathology is neglected due to poor understanding among both physicians and travelers. This study describes the profile of cases reported in Marseille, France. PATIENTS AND METHODS: A retrospective study was performed in two specialized hospitals between 2003 and 2015...
June 15, 2017: Travel Medicine and Infectious Disease
https://www.readbyqxmd.com/read/28617145/defining-treatment-success-in-rosacea-as-clear-may-provide-multiple-patient-benefits-results-of-a-pooled-analysis
#3
Guy Webster, Martin Schaller, Jerry Tan, J Mark Jackson, Nabil Kerrouche, Gregor Schäfer
Background Rosacea treatment success is usually defined as a score of 1 ("almost clear") or 0 ("clear") on the 5-point Investigator Global Assessment (IGA) scale. Objective To evaluate whether after successful treatment, "clear" subjects had better outcomes than "almost clear" subjects. Methods A pooled analysis was performed on 1366 rosacea subjects from 4 randomized controlled trials with IGA before and after treatment (ivermectin, metronidazole or vehicle). Assessments included the Dermatology Life Quality Index (DLQI) questionnaire and subject assessment of rosacea improvement...
June 15, 2017: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/28615883/clinicobiochemical-changes-in-ivermectin-toxicity-in-doberman-pinscher-pups
#4
Sahadeb Dey, Nitin P Kurade, Kishore Lal Khurana, Ananya Dan
This study is based on naturally intoxicated Doberman pinscher pups. Six Doberman pinscher pups were overdosed 50 times of recommended ivermectin dose by the pet owner and presented to Referral Veterinary Polyclinic section of this institute in a state of coma. The pups were unable to hold their head up and had no pupillary reflex. The pups were examined clinically and samples of blood were taken for haemato-biochemical studies, before and after treatment. During intoxication there was marked haemoconcentration, increase in values of serum creatinine phosphokinase, gamma glutamyl transpeptidase but decrease in serum glucose levels...
June 2017: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
https://www.readbyqxmd.com/read/28615845/efficacy-of-ivermectin-closantel-and-fenbendazole-against-gastrointestinal-nematodes-of-sheep-in-kashmir-valley
#5
S R Tramboo, R A Shahardar, I M Allaie, Z A Wani, Maria Abbas
The present work was undertaken to evaluate the therapeutic efficacy of ivermectin, closantel and fenbendazole under field conditions against Gastrointestinal Nematodes (GIN) of cross bred merino sheep in Budgam area of Kashmir Valley. A total of 115 sheep having Egg per gram of faeces (EPG) greater than or equal to 150 (mean EPG 258.89) were selected. The animals were randomly divided into four groups comprising of 30 animals each in three treatment groups (ivermectin, closantel and fenbendazole) and twenty-five in fourth untreated infected control group...
June 2017: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
https://www.readbyqxmd.com/read/28600751/central-and-peripheral-nervous-system-disorders-following-ivermectin-mass-administration-a-descriptive-study-based-on-the-democratic-republic-of-congo-pharmacovigilance-system
#6
Didier Nzolo, Francis Anto, Sarah Hailemariam, Didier Bakajika, Daniel Muteba, Jean-Claude Makenga, Gautier Mesia, Celestin Nsibu, Samuel Mampunza, Gaston Tona
INTRODUCTION: The mainstay of onchocerciasis control currently is mass administration of ivermectin; however, this may be associated with serious adverse events, including deaths, when administered in areas where onchocerciasis and loiasis are co-endemic. OBJECTIVES: The objective of the current study was to describe the central and peripheral nervous system disorders that occurred after mass administration of ivermectin in Democratic Republic of Congo (DRC). METHODS: This is a retrospective descriptive study involving a review of data on adverse events related to mass administration of ivermectin...
June 9, 2017: Drugs—Real World Outcomes
https://www.readbyqxmd.com/read/28596826/field-evaluation-of-the-efficacy-of-common-anthelmintics-used-in-the-control-of-gastrointestinal-nematodes-of-sheep-in-dabat-district-northwest-ethiopia
#7
Zewdu Seyoum, Yitayew Demessie, Basazinew Bogale, Achenef Melaku
BACKGROUND: Gastrointestinal nematode (GIN) infections are the main impediments that restrict the welfare and productivity of small ruminant in the world. Effective management of GINs in grazing sheep relies heavily on the use of highly efficacious anthelmintic drugs. However, anthelmintic resistance is becoming a significant concern in the world, and this phenomenon severely threatens the potential utilisation of this control strategy. Therefore, this study was conducted 1) to evaluate the efficacy of commonly used anthelmintic on GINs in naturally infected sheep and 2) to assess the farmers' perception on anthelmintics utilisation practices in Dabat district, Northwest Ethiopia...
2017: Irish Veterinary Journal
https://www.readbyqxmd.com/read/28595672/in-vitro-larvicidal-and-in-vivo-anthelmintic-effects-of-oxalis-tetraphylla-oxalidaceae-hydroalcoholic-extract-against-haemonchus-contortus-in-lambs
#8
B J González-Cruz, M Rodríguez-Labastida, M González-Cortázar, A Zamilpa, M E López-Arellano, L Aguilar-Marcelino, R González-Garduño, J F J Torres-Acosta, A Olmedo-Juárez, P Mendoza-de Gives
The in vitro larvicidal and in vivo anthelmintic effects of Oxalis tetraphylla hydroalcoholic extract (HE), against Haemonchus contortus in experimentally infected lambs, were assessed. We used a microtitration plate method, comprising the following two stages. Stage 1: 20 μl of water containing 200 sheathed H. contortus infective larvae (ShHcl) were deposited in every well of three series; then, the series 2 and 3 wells were treated with 80 μl 1% ivermectin and O. tetraphylla HE at 20 mg/ml, respectively...
June 9, 2017: Journal of Helminthology
https://www.readbyqxmd.com/read/28593247/demodex-positive-acneiform-eruption-responsive-to-ivermectin-in-a-patient-taking-an-epidermal-growth-factor-inhibitor
#9
Trevor B Parker, Adam B Blechman, Barbara B Wilson
No abstract text is available yet for this article.
June 7, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/28592295/angiostrongylus-vasorum-infection-in-dogs-from-a-cardiopulmonary-dirofilariosis-endemic-area-of-northwestern-italy-a-case-study-and-a-retrospective-data-analysis
#10
Emanuela Olivieri, Sergio Aurelio Zanzani, Alessia Libera Gazzonis, Chiara Giudice, Paola Brambilla, Isa Alberti, Stefano Romussi, Rocco Lombardo, Carlo Maria Mortellaro, Barbara Banco, Federico Maria Vanzulli, Fabrizia Veronesi, Maria Teresa Manfredi
BACKGROUND: In Italy, Angiostrongylus vasorum, an emergent parasite, is being diagnosed in dogs from areas considered free of infection so far. As clinical signs are multiple and common to other diseases, its diagnosis can be challenging. In particular, in areas where angiostrongylosis and dirofilariosis overlap, a misleading diagnosis of cardiopulmonary dirofilariosis might occur even on the basis of possible misleading outcomes from diagnostic kits. CASE PRESENTATION: Two Cavalier King Charles spaniel dogs from an Italian breeding in the Northwest were referred to a private veterinary hospital with respiratory signs...
June 7, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28591263/myiasis-associated-with-an-invasive-ductal-carcinoma-of-the-left-breast-case-study
#11
Felipe Tavares Rodrigues, Larissa Raquel Klemig, Marcos Roberto Pereira Cardozo, Paulo Cesar Alves, Valéria Magalhães Aguiar, Claudia Soares Lessa
Most breast cancers originate in the ductal epithelium and are referred to as invasive ductal carcinoma. In this study we report on the clinical procedures adopted to diagnose myiasis in association with infiltrating metastatic breast carcinoma in a female patient. A 41 years old woman came to the Federal Hospital of Andaraí complaining of intense itching, warmth, redness and hardening of the breast, which had acquired the aspect of an orange peel. A lesion in the left breast was cavitated, dimpled, had fetid odor, and had fibrotic and infected air nodules filled with exudate and Dipteran larvae...
June 1, 2017: Revista do Instituto de Medicina Tropical de São Paulo
https://www.readbyqxmd.com/read/28590725/discovery-of-a-cryptic-antifungal-compound-from-streptomyces-albus-j1074-using-high-throughput-elicitor-screens
#12
Fei Xu, Behnam Nazari, Kyuho Moon, Leah B Bushin, Mohammad R Seyedsayamdost
An important unresolved issue in microbial secondary metabolite production is the abundance of biosynthetic gene clusters that are not expressed under typical laboratory growth conditions. These so-called silent or cryptic gene clusters are sources of new natural products, but how they are silenced, and how they may be rationally activated are areas of ongoing investigation. We recently devised a chemogenetic high-throughput screening approach ('HiTES') to discover small molecule elicitors of silent biosynthetic gene clusters...
June 7, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28590167/effects-of-in-vivo-and-in-vitro-treatment-of-ascaris-suum-eggs-with-anthelmintic-agents-on-embryonation-and-infectivity-for-mice
#13
Jianguo Zhao, Qian Han, Chenghong Liao, Jinhua Wang, Lili Wu, Qun Liu, David S Lindsay
Ascaris suum is an important intestinal nematode causing economic losses in the swine production industry. Anthelminthic treatment is used to control A. suum infections and is part of normal production practices. Treatment with anthelminthic agents results in expulsion of adult worms from the intestinal tract and ends further contamination of the environment with eggs. The present study was conducted to determine the effects of drug treatment on the embryonation of A. suum eggs collected from worms obtained from pigs treated with 4 different commercially available anthelmintics...
June 7, 2017: Journal of Parasitology
https://www.readbyqxmd.com/read/28588493/p2x4-receptor-function-in-the-nervous-system-and-current-breakthroughs-in-pharmacology
#14
REVIEW
Leanne Stokes, Janice A Layhadi, Lucka Bibic, Kshitija Dhuna, Samuel J Fountain
Adenosine 5'-triphosphate is a well-known extracellular signaling molecule and neurotransmitter known to activate purinergic P2X receptors. Information has been elucidated about the structure and gating of P2X channels following the determination of the crystal structure of P2X4 (zebrafish), however, there is still much to discover regarding the role of this receptor in the central nervous system (CNS). In this review we provide an overview of what is known about P2X4 expression in the CNS and discuss evidence for pathophysiological roles in neuroinflammation and neuropathic pain...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28587669/ivermectin-treated-cattle-reduces-blood-digestion-egg-production-and-survival-of-a-free-living-population-of-anopheles-arabiensis-under-semi-field-condition-in-south-eastern-tanzania
#15
Issa N Lyimo, Stella T Kessy, Kasian F Mbina, Ally A Daraja, Ladslaus L Mnyone
BACKGROUND: Anopheles arabiensis feed on cattle and contributes to residual transmission of malaria in areas with high coverage of long-lasting insecticide-treated nets and indoor residual spraying in East Africa. This study aimed to evaluate the effects of ivermectin-treated cattle as a complementary vector control tool against population of An. arabiensis under the semi-field conditions in south-eastern Tanzania. METHODS: The free-living population of An. arabiensis was allowed to forage on untreated or ivermectin-treated cattle in alternating nights within the semi-field system in south-eastern Tanzania...
June 6, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28579708/field-based-evidence-of-single-and-few-doses-of-annual-ivermectin-treatment-efficacy-in-eliminating-skin-microfilaria-load-after-a-decade-of-intervention
#16
Hudu O Osue
BACKGROUND: Impact assessment of community-based ivermectin treatment control of onchocerciasis is required to determine its effectiveness. This study was conducted to evaluate geographic coverage and demographic ivermectin treatment compliance. METHODS: The number of village dosage were obtained from the community based distributors. Bioclinical data of participants comprising gender, age, number of treatment received from inception and dosage were obtained. Each participant was subjected to physical examination for palpable nodule and other skin clinical signs and symptoms of onchocerciasis...
March 2017: Ethiopian Journal of Health Sciences
https://www.readbyqxmd.com/read/28561292/guideline-for-the-diagnosis-and-treatment-of-scabies-in-japan-third-edition-executive-committee-of-guideline-for-the-diagnosis-and-treatment-of-scabies
#17
(no author information available yet)
In the current work, we present our new guideline for the diagnosis and treatment of scabies which we, the Executive Committee convened by the Japanese Dermatological Association, developed to ensure proper diagnosis and treatment of scabies in Japan. Approval of phenothrin topical use under the National Health Insurance in August 2014 led to this action. Permethrin, a topical anti-scabietic medication belonging to the same pyrethroid group as phenothrin, is already in use worldwide. In this guideline, we introduce criteria for a proper diagnosis of scabies, treatment algorithm for common and crusted (hyperkeratotic) scabies, and prevention...
May 31, 2017: Journal of Dermatology
https://www.readbyqxmd.com/read/28559258/in-vitro-efficacy-of-moxidectin-versus-ivermectin-against-sarcoptes-scabiei
#18
Kate E Mounsey, Shelley F Walton, Ashlee Innes, Skye Cash-Deans, James S McCarthy
Moxidectin is under consideration for development as a treatment for human scabies. As some arthropods show decreased sensitivity to moxidectin relative to ivermectin, it was important to assess this for Sarcoptes scabieiIn-vitro assays showed that the concentration of moxidectin required to kill 50% of mites was lower compared to ivermectin (0.5 μM vs 1.8 μM at 24 hours, p <0.0001). This finding provides further support for moxidectin as a candidate for the treatment of human scabies.
May 30, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28549173/incidental-mosquitocidal-effect-of-an-ivermectin-mass-drug-administration-on-anopheles-farauti-conducted-for-scabies-control-in-the-solomon-islands
#19
Christian Kositz, Jeptah Talina, Jason Diau, Rowena Asugeni, Cheryl Whitehorn, David Mabey, Carlos Chaccour, Michael Marks
Background: The Solomon Islands is targeting elimination of malaria by 2030. The dominant vector is the predominantly exophagic, exophilic Anopheles farauti sensu strictu. This biting behaviour limits the efficacy of conventional vector control tools and highlights the need for new strategies. When administered to humans ivermectin has been shown to have a mosquitocidal effect. Mass drug administration (MDA) with ivermectin is an emerging strategy in the control of scabies. In this study we explored any incidental effect of ivermectin MDA conducted for scabies control on mosquitoes...
March 1, 2017: Transactions of the Royal Society of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28537782/a-field-study-on-the-anthelmintic-resistance-of-parascaris-spp-in-arab-foals-in-the-riyadh-region-saudi-arabia
#20
Abdullah D Alanazi, Rami M Mukbel, Mohamed S Alyousif, Zafer S AlShehri, Ibrahim O Alanazi, Hamdan I Al-Mohammed
BACKGROUND: In the last decade, Parascaris spp. resistance to anthelmintics has been recorded in many countries. In Saudi Arabia, there are limited data available on Parascaris spp. resistance to anthelmintics. OBJECTIVE: To determine the current status of ivermectin, abamectin and praziquantel combined, and fenbendazole resistance to Parascaris spp. in horses in Saudi Arabia. METHODS: Three hundred and forty-one foals from eleven different farms were examined by faecal egg count (FEC)...
December 2017: Veterinary Quarterly
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