keyword
MENU ▼
Read by QxMD icon Read
search

Ivermectin

keyword
https://www.readbyqxmd.com/read/28438169/ivermectin-and-malaria-control
#1
Satoshi Ōmura, Andy Crump
As the world begins to realize the very real prospect of eliminating malaria as a public health problem globally, the scientific community is acutely aware that novel and innovative new tools will be required if that lofty goal is to be accomplished. Moreover, the need for comprehensive, integrated products and interventions is being recognized in order for the critical 'final steps' toward elimination to be taken successfully. Failure to take these crucial last steps have dogged all past global disease elimination programmes, except for smallpox...
April 24, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28438168/upon-entering-an-age-of-global-ivermectin-based-integrated-mass-drug-administration-for-neglected-tropical-diseases-and-malaria
#2
Frank O Richards
Ivermectin mass drug administration (MDA) in humans to reduce malaria vectors is yet another use for this remarkable medicine whose discoverers shared the 2015 Nobel Prize in Medicine with the discoverer of artemisinin. The malaria community should join those who have long used ivermectin MDA in an integrated battle to break transmission of three vector-borne parasitic diseases.
April 24, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28434407/ivermectin-to-reduce-malaria-transmission-iii-considerations-regarding-regulatory-and-policy-pathways
#3
REVIEW
Carlos Chaccour, N Regina Rabinovich
Vector control is a task previously relegated to products that (a) kill the mosquitoes directly at different stages (insecticides, larvicides, baited traps), or (b) avoid/reduce human-mosquito contact (bed nets, repellents, house screening), thereby reducing transmission. The potential community-based administration of the endectocide ivermectin with the intent to kill mosquitoes that bite humans, and thus reduce malaria transmission, offers a novel approach using a well-known drug, but additional steps are required to address technical, regulatory and policy gaps...
April 24, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28434405/ivermectin-to-reduce-malaria-transmission-ii-considerations-regarding-clinical-development-pathway
#4
REVIEW
Carlos Chaccour, N Regina Rabinovich
The development of ivermectin as a complementary vector control tool will require good quality evidence. This paper reviews the different eco-epidemiological contexts in which mass drug administration with ivermectin could be useful. Potential scenarios and pharmacological strategies are compared in order to help guide trial design. The rationale for a particular timing of an ivermectin-based tool and some potentially useful outcome measures are suggested.
April 24, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28434401/ivermectin-to-reduce-malaria-transmission-i-pharmacokinetic-and-pharmacodynamic-considerations-regarding-efficacy-and-safety
#5
REVIEW
Carlos Chaccour, Felix Hammann, N Regina Rabinovich
Ivermectin is an endectocide that has been used broadly in single dose community campaigns for the control of onchocerciasis and lymphatic filariasis for more than 30 years. There is now interest in the potential use of ivermectin regimens to reduce malaria transmission, envisaged as community-wide campaigns tailored to transmission patterns and as complement of the local vector control programme. The development of new ivermectin regimens or other novel endectocides will require integrated development of the drug in the context of traditional entomological tools and endpoints...
April 24, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28433409/managing-anthelmintic-resistance-in-parascaris-spp-a-modelling-exercise
#6
Dave M Leathwick, Christian W Sauermann, Thomas Geurden, Martin K Nielsen
A previously described model for the dynamics of the parasitic stages of Parascaris spp. was modified to include eggs outside the host and the genetics of anthelmintic resistance before being used to address questions regarding the development of resistance. Three broad questions were addressed; i) How sustainable is the current common practice of treating foals monthly for their first year of life (i.e. 12 treatments/year)? ii) Does the timing of treatments have an effect on resistance development? (i.e. do certain treatments select for resistance more strongly than others?), and iii) How sustainable is the currently recommended strategy of targeting ascarid infections in foals with two treatments applied during the first five months of life? A range of variations within these broad questions were considered, such as the value in rotational deworming, whether larvicidal treatments are more selective for resistance, and whether combination anthelmintics should be introduced...
March 30, 2017: Veterinary Parasitology
https://www.readbyqxmd.com/read/28432479/pharmacokinetics-and-efficacy-of-an-ivermectin-implant-for-long-term-prevention-of-dirofilaria-immitis-infection-in-dogs
#7
Marco Genchi, Anne Geneteau, Patrick Forget, Romain Delcombel, Claudio Genchi
An exploratory study was carried out to assess the in vivo efficacy of different prototypes of subcutaneous implants containing ivermectin (IVM) for the prevention of canine Dirofilaria immitis infection. The implants consisted of an ethylcellulose matrix containing IVM (3.0, 4.5, and 6.0 mg/implant; from 0.29 to 0.63 mg/kg bw) as active ingredient designed to release approximately 0.1 ng of IVM/mL in the plasma for at least 12 months. Six dogs were implanted on day -365. On day -12, three heartworm-free dogs were included in the study as a control group...
April 22, 2017: Parasitology Research
https://www.readbyqxmd.com/read/28428744/mutational-analysis-at-intersubunit-interfaces-of-an-anionic-glutamate-receptor-reveals-a-key-interaction-important-for-channel-gating-by-ivermectin
#8
Nurit Degani-Katzav, Revital Gortler, Marina Weissman, Yoav Paas
The broad-spectrum anthelmintic drug ivermectin (IVM) activates and stabilizes an open-channel conformation of invertebrate chloride-selective glutamate receptors (GluClRs), thereby causing a continuous inflow of chloride ions and sustained membrane hyperpolarization. These effects suppress nervous impulses and vital physiological processes in parasitic nematodes. The GluClRs are pentamers. Homopentameric receptors assembled from the Caenorhabditis elegans (C. elegans) GluClα (GLC-1) subunit can inherently respond to IVM but not to glutamate (the neurotransmitter)...
2017: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/28420428/significant-heterogeneity-in-wolbachia-copy-number-within-and-between-populations-of-onchocerca-volvulus
#9
Samuel Armoo, Stephen R Doyle, Mike Y Osei-Atweneboana, Warwick N Grant
BACKGROUND: Wolbachia are intracellular bacteria found in arthropods and several filarial nematode species. The filarial Wolbachia have been proposed to be involved in the immunopathology associated with onchocerciasis. Higher Wolbachia-to-nematode ratios have been reported in the savannah-ecotype compared to the forest-ecotype, and have been interpreted as consistent with a correlation between Wolbachia density and disease severity. However, factors such as geographic stratification and ivermectin drug exposure can lead to significant genetic heterogeneity in the nematode host populations, so we investigated whether Wolbachia copy number variation is also associated with these underlying factors...
April 18, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28414672/a-strong-and-fortuitous-case-of-dyspnea
#10
R Hammer, M Sciaudone
CASE: A 48 year-old man with no past medical history was sent to our emergency department (ED); from a primary care clinic for hypertensive urgency of 200/130. The man reported an intermittent non-productive cough of approximately one year's duration and worsening dyspnea on exertion and orthopnea over the last month with lower extremity swelling. Of note, he emigrated from Honduras twenty years ago. Blood pressure normalized with administration of Lasix in the ED. Physical exam revealed rales in lung bases bilaterally, jugular venous distension, lower extremity pitting edema with serpiginous patches of erythema and excoriation, and a cardiac gallop...
March 2017: Journal of the Louisiana State Medical Society: Official Organ of the Louisiana State Medical Society
https://www.readbyqxmd.com/read/28414046/caffeoyl-and-coumaroyl-derivatives-from-acacia-cochliacantha-exhibit-ovicidal-activity-against-haemonchus-contortus
#11
G F Castillo-Mitre, A Olmedo-Juárez, R Rojo-Rubio, M Cortázar-González, P Mendoza-de Gives, E E Hernández-Beteta, D E Reyes-Guerrero, M E López-Arellano, J F Vázquez-Armijo, G Ramírez-Vargas, A Zamilpa
Ethnopharmacology relevance: Acacia cochliacantha is a small tree whose foliage is traditionally used in Mexico for treatment of kidney pain, gastrointestinal illnesses and to kill intestinal parasites. In recent decades, the study of vegetal extracts has offered other possible alternatives for the control of Haemonchus contortus. Considering that this nematode affects dramatically the health and productivity of small ruminants, the aim of this study was to identify the anthelmintic compounds from A. cochliacantha hydro-alcoholic extract (HA-E) through an ovicidal test...
April 14, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28408046/-evaluation-of-practices-in-the-management-of-scabies-in-children
#12
M-S Lê, M-A Richard, K Baumstarck, S Hesse, C Gaudy-Marqueste, J-J Grob, S Mallet
BACKGROUND: Scabies has been on the rise in France in recent years and has posed therapeutic problems, mainly due to the withdrawal of benzyl benzoate. The objective of this study was to describe prescribing practices for scabies in children. METHODS: A national survey was conducted by means of a standardized questionnaire covering various clinical situations of scabies and the drugs used preferentially according to age, which was sent out between December 2014 and March 2015 to members of the clinical research group of the French Society of Paediatric Dermatology...
April 10, 2017: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/28398415/misdiagnosed-crusted-scabies-in-an-aids-patient-leads-to-hyperinfestation
#13
Niloofar Yari, C Helen Malone, Antonio Rivas
Crusted scabies is a severe, highly contagious form of classic scabies caused by the mite Sarcoptes scabiei var hominis. Crusted scabies is more common in immunosuppressed populations and overcrowded environments. In this condition, the host's immune system is overwhelmed and unable to defend against the mites on the skin, resulting in hyperinfestation of the host. Diagnosis can be challenging because the condition resembles other common skin conditions, such as plaque psoriasis. Furthermore, delayed diagnosis and inappropriate treatment can lead to worsening of the condition...
March 2017: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/28389861/in-vitro-larvicidal-effect-of-a-hydroalcoholic-extract-from-acacia-cochliacantha-leaf-against-ruminant-parasitic-nematodes
#14
Agustín Olmedo-Juárez, Rolando Rojo-Rubio, Alejandro Zamilpa, Pedro Mendoza de Gives, Javier Arece-García, María Eugenia López-Arellano, Elke von Son-de Fernex
The aim of this study was to evaluate the in vitro lethal effect of a hydroalcoholic extract (HAE) from Acacia cochliacantha leaf against three gastrointestinal nematodes species (Haemonchus contortus, H. placei and Cooperia punctata) of domestic ruminants. The HAE was assessed using five concentrations: 100, 125, 175, 150 and 200 mg/ml; 0.5% Ivermectin was used as a positive control and distilled water, as negative control. The data were normalized using the square root and analysed with a completely randomized design through ANOVA analysis using the general lineal model (GLM) of the SAS program...
April 8, 2017: Veterinary Research Communications
https://www.readbyqxmd.com/read/28388639/the-current-status-of-resistance-to-alpha-cypermethrin-ivermectin-and-amitraz-of-the-cattle-tick-rhipicephalus-microplus-in-ecuador
#15
Richar Rodríguez-Hidalgo, Ximena Pérez-Otáñez, Sandra Garcés-Carrera, Sophie O Vanwambeke, Maxime Madder, Washington Benítez-Ortiz
Rhipicephalus microplus is widely distributed in tropical and subtropical areas of the world where livestock is a principal activity with great veterinary and economic importance. In Ecuador, this hematophagous ectoparasite has been observed between 0 and 2600 masl. One of the main tick control measures is the use of acaricides, which have been indiscriminately used worldwide and in Ecuador. In this country, no studies on acaricide resistance in Rhipicephalus microplus have been published. The current study aims to characterise the level of resistance of R...
2017: PloS One
https://www.readbyqxmd.com/read/28385424/treatment-of-human-scabies-with-oral-ivermectin-eczematous-eruptions-as-a-new-non-reported-adverse-event
#16
J Sanz-Navarro, C Feal, E Dauden
BACKGROUND: Oral ivermectin is an alternative therapy for human scabies infection due to its ease of administration and good safety profile. However, there is no definitive consensus on the optimal dosing regimen. OBJECTIVE: To describe the treatment of human scabies with different dosages of oral ivermectin and the possible adverse events. METHODS: 23 patients with human scabies were treated with oral ivermectin: 10 patients received a single oral dose of 200μg/kg and 13 a dose of 400μg/kg...
April 3, 2017: Actas Dermo-sifiliográficas
https://www.readbyqxmd.com/read/28384914/orbital-myiasis-with-scalp-pediculosis-and-buccal-abscess-an-uncommon-presentation
#17
Nidhi Kaeley, Rajeev Mohan Kaushik, Richa Rajput, Renu Dhasmana, Anurag Bhargava
We present a case of severe orbital myiasis caused by Osteris ovis, also known as sheep nasal botfly which is an uncommon manifestation of maggot infestation. Our patient was successfully treated with oral as well as topical ivermectin. The experience of ivermectin as an anti-parasitic agent in the treatment of orbital myiasis, although a known entity, is still limited among medical professionals including ophthalmologists. Thus, we would like to highlight the role of oral ivermectin as an anti-parasitic agent in the treatment of orbital myiasis facilitating the removal of maggots; thus, precluding the need for exploratory surgery...
February 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28381279/loa-loa-vectors-chrysops-spp-perspectives-on-research-distribution-bionomics-and-implications-for-elimination-of-lymphatic-filariasis-and-onchocerciasis
#18
REVIEW
Louise Kelly-Hope, Rossely Paulo, Brent Thomas, Miguel Brito, Thomas R Unnasch, David Molyneux
BACKGROUND: Loiasis is a filarial disease caused Loa loa. The main vectors are Chrysops silacea and C. dimidiata which are confined to the tropical rainforests of Central and West Africa. Loiasis is a mild disease, but individuals with high microfilaria loads may suffer from severe adverse events if treated with ivermectin during mass drug administration campaigns for the elimination of lymphatic filariasis and onchocerciasis. This poses significant challenges for elimination programmes and alternative interventions are required in L...
April 5, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28380118/in-vitro-efficacy-of-latex-and-purified-papain-from-carica-papaya-against-strongyloides-venezuelensis-eggs-and-larvae
#19
Dayane Moraes, Marcelo Arantes Levenhagen, Julia Maria Costa-Cruz, Antônio Paulino da Costa, Rosângela Maria Rodrigues
Latex from Carica papaya is rich in bioactive compounds, especially papain, which may help to control parasitic diseases. This study evaluated the efficacy of latex from C. papaya and purified papain against Strongyloides venezuelensis. The Egg Hatching Test (EHT) and the Larval Motility Test (LMT) using fresh and frozen latex (250mg/mL), lyophilized latex (34mg/mL), and purified papain (2.8 mg/mL) were performed. Albendazole (0.025 mg/mL) and ivermectin (316 ppm) were used as positive controls. EHT and LMT were carried out through the incubation of each solution with S...
April 3, 2017: Revista do Instituto de Medicina Tropical de São Paulo
https://www.readbyqxmd.com/read/28372977/effect-of-3-years-of-biannual-mass-drug-administration-with-albendazole-on-lymphatic-filariasis-and-soil-transmitted-helminth-infections-a-community-based-study-in-republic-of-the-congo
#20
Sébastien D S Pion, Cédric B Chesnais, Gary J Weil, Peter U Fischer, François Missamou, Michel Boussinesq
BACKGROUND: The standard treatment strategy of mass drug administration with ivermectin plus albendazole for lymphatic filariasis cannot be applied in central Africa, because of the risk of serious adverse events in people with high Loa loa microfilaraemia. Thus, alternative strategies are needed. We investigated one such alternative strategy for mass drug administration for elimination of lymphatic filariasis and soil-transmitted helminth infections in Republic of the Congo. METHODS: In 2012, we started a 3 year community trial of biannual mass administration of albendazole in a village in Republic of the Congo...
March 31, 2017: Lancet Infectious Diseases
keyword
keyword
72985
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"