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https://www.readbyqxmd.com/read/28219601/syndrome-of-inappropriate-anti-diuretic-hormone-secretion-secondary-to-strongyloides-stercoralis-infection-in-an-allogeneic-stem-cell-transplant-patient-a-case-report-and-literature-review
#1
M Khushman, M I Morris, L Diaz, M Goodman, D Pereira, K Fuller, M Garcia-Buitrago, B Moshiree, S Zelaya, A Nayer, C L Benjamin, K V Komanduri
Syndrome of inappropriate anti-diuretic hormone (SIADH) has been reported to be associated with systemic Strongyloides stercoralis. Here, we report a case of a stem cell transplant (SCT) recipient who developed severe SIADH secondary to systemic S Stercoralis. The SIADH resolved quickly after treating the systemic S Stercoralis with ivermectin. A systematic review of the literature was performed by PubMed, Scopus, and Cochrane database search. Only eight cases of S Stercoralis in allogeneic SCT recipients have been previously reported...
March 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/28218274/trapping-of-ivermectin-by-a-pentameric-ligand-gated-ion-channel-upon-open-to-closed-isomerization
#2
Nurit Degani-Katzav, Moshe Klein, Moran Har-Even, Revital Gortler, Ruthi Tobi, Yoav Paas
Ivermectin (IVM) is a broad-spectrum anthelmintic drug used to treat human parasitic diseases like river blindness and lymphatic filariasis. By activating invertebrate pentameric glutamate-gated chloride channels (GluCl receptors; GluClRs), IVM induces sustained chloride influx and long-lasting membrane hyperpolarization that inhibit neural excitation in nematodes. Although IVM activates the C. elegans heteromeric GluClα/β receptor, it cannot activate a homomeric receptor composed of the C. elegans GluClβ subunits...
February 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28215917/onchocerciasis-in-the-democratic-republic-of-congo-survey-of-knowledge-attitude-and-perception-in-bandundu-province
#3
Jean-Claude Makenga Bof, Dieudonne Mpunga, Emery N Soa, Fortunat Ntumba, Didier Bakajika, Michele E Murdoch, Yves Coppieters
A community-directed treatment with ivermectin (CDTI) for fighting onchocerciasis was started in 2003 in the hyperendemic province of Bandundu, Democratic Republic of Congo (DRC); such initiative was supported by the African Programme for Onchocerciasis Control (APOC). As the APOC stopped at the end of 2015, there was an urgent need to assess the sustainability of an ivermectin treatment. A cross-sectional survey of knowledge, attitude and perception was conducted to determine the awareness level of local population regarding the disease...
February 16, 2017: Journal of Infection and Public Health
https://www.readbyqxmd.com/read/28215861/effects-of-anthelmintic-treatment-and-feed-supplementation-on-parasite-infections-and-morbidity-parameters-in-cambodian-cattle
#4
Veronique Dermauw, Sothy Meas, Bunthon Chea, Thierry Onkelinx, San Sorn, Davun Holl, Johannes Charlier, Jozef Vercruysse, Pierre Dorny
Helminth infections are the cause of morbidity in Cambodian cattle but other factors such as nutritional deficiencies and concurrent diseases may enhance the effects of parasites. The present study aimed to investigate the impact of anthelmintic treatment, feed supplementation, or both on gastrointestinal strongyle (GIS) and trematode infections as well as on morbidity parameters in Cambodian village cattle. At the beginning of the dry season, cattle populations in six villages were randomly assigned to a group: (A) receiving anthelmintic treatment (ivermectin+clorsulon) at week 0; (P) feed pellet supplementation during week 0-13 or both (AP)...
February 15, 2017: Veterinary Parasitology
https://www.readbyqxmd.com/read/28212765/ivermectin-therapy-for-papulopustular-rosacea-and-periorificial-dermatitis-in-children-a-series-of-15-cases
#5
Lucero Noguera-Morel, Paula Gerlero, Antonio Torrelo, Ángela Hernández-Martín
No abstract text is available yet for this article.
March 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28210503/strongyloidiasis-current-status-with-emphasis-in-diagnosis-and-drug-research
#6
REVIEW
Tiago Mendes, Karen Minori, Marlene Ueta, Danilo Ciccone Miguel, Silmara Marques Allegretti
Strongyloidiasis is a parasitic neglected disease caused by the nematode Strongyloides stercoralis affecting 30 to 100 million people worldwide. Complications, strongly associated with alcoholism, organ transplants, and HTLV-1 virus, often arise due to late diagnosis, frequently leading to patient death. Lack of preemptive diagnosis is not the only difficulty when dealing with this parasite, since there are no gold standard diagnostic techniques, and the ones used have problems associated with sensitivity, resulting in false negatives...
2017: Journal of Parasitology Research
https://www.readbyqxmd.com/read/28207908/isolation-and-determination-of-ivermectin-in-post-mortem-and-in-vivo-tissues-of-dung-beetles-using-a-continuous-solid-phase-extraction-method-followed-by-lc-esi-ms-ms
#7
Antonio J Ortiz, Vieyle Cortez, Abdelmonaim Azzouz, José R Verdú
A new analytical method based on solvent extraction, followed by continuous solid-phase extraction (SPE) clean-up using a polymeric sorbent, was demonstrated to be applicable for the detection of ivermectin in complex biological matrices of dung beetles (hemolymph, excreta or dry tissues) using liquid chromatography combined with positive electrospray ionization tandem mass spectrometry (LC/ESI+-MS/MS). Using a signal-to-noise ratio of 3:1, the limit of detection (LOD) in the insect matrices at trace levels was 0...
2017: PloS One
https://www.readbyqxmd.com/read/28196978/ivermectin-enigmatic-multifaceted-wonder-drug-continues-to-surprise-and-exceed-expectations
#8
REVIEW
Andy Crump
Over the past decade, the global scientific community have begun to recognize the unmatched value of an extraordinary drug, ivermectin, that originates from a single microbe unearthed from soil in Japan. Work on ivermectin has seen its discoverer, Satoshi Ōmura, of Tokyo's prestigious Kitasato Institute, receive the 2014 Gairdner Global Health Award and the 2015 Nobel Prize in Physiology or Medicine, which he shared with a collaborating partner in the discovery and development of the drug, William Campbell of Merck & Co...
February 15, 2017: Journal of Antibiotics
https://www.readbyqxmd.com/read/28192198/molecular-cloning-purification-and-characterization-of-brugia-malayi-phosphoglycerate-kinase
#9
Ranjeet Kumar, Pawan Kumar Doharey, Jitendra Kumar Saxena, Sushma Rathaur
Phosphoglycerate kinase (PGK) is a glycolytic enzyme present in many parasites. It has been reported as a candidate molecule for drug and vaccine developments. In the present study, a full-length cDNA encoding the Brugia malayi 3-phosphoglycerate kinase (BmPGK) with an open reading frame of 1.3 kb was isolated and PCR amplified and cloned. The exact size of the BmPGK's ORF is 1377 bps. The BmPGK gene was subcloned into pET-28a (+) expression vector, the expressed enzyme was purified by affinity column and characterized...
February 9, 2017: Protein Expression and Purification
https://www.readbyqxmd.com/read/28187990/how-to-contain-artemisinin-and-multidrug-resistant-falciparum-malaria
#10
REVIEW
Arjen M Dondorp, Frank M Smithuis, Charley Woodrow, Lorenz von Seidlein
In the Greater Mekong subregion (GMS), artemisinin resistance is increasingly compounded by partner drug resistance, causing high failure rates of artemisinin combination therapies in some areas. For its containment, an accelerated elimination strategy will be needed. This includes high-quality implementation of conventional malaria control measures: early case management with quality artemisinin combination therapies (avoiding artesunate monotherapies) and single gametocytocidal low dose of primaquine, vector control and surveillance...
February 7, 2017: Trends in Parasitology
https://www.readbyqxmd.com/read/28131090/toxicity-of-four-veterinary-pharmaceuticals-on-the-survival-and-reproduction-of-folsomia-candida-in-tropical-soils
#11
Talyta Zortéa, Julia C Segat, Ana Paula Maccari, José Paulo Sousa, Aleksandro S Da Silva, Dilmar Baretta
This study aimed to evaluate the effect of veterinary pharmaceuticals (VPs) used to control endo- and ectoparasites in ruminants, on the survival and reproduction of the collembolan species Folsomia candida. Standard ecotoxicological tests were conducted in Tropical Artificial Soil and the treatments consisted of increasing dosages of four commercial products with different active ingredients: ivermectin, fipronil, fluazuron and closantel. Ecotoxicological effects were related to the class and mode of action of the different compounds...
January 12, 2017: Chemosphere
https://www.readbyqxmd.com/read/28124136/new-techniques-to-collect-live-sarcoptes-scabiei-and-evaluation-of-methods-as-alternative-diagnostics-for-infection
#12
Nobuhide Kido, Teruo Akuta, Hiroshi Tarui, Keitaro Imaizumi, Takafumi Ueda, Yasuo Ono, Takane Kikuchi-Ueda, Sohei Tanaka, Tomoko Omiya
Sarcoptes scabiei is a widespread, highly contagious skin disease that affects many mammals including humans. The biological characteristics of S. scabiei remain unclear. Therefore, the ability to collect adequate amount of mites for studies is required to advance our understanding of the parasite. The present study aimed to find a method to collect an adequate amount of live S. scabiei mites within a short time frame. The cornified layer and fur from an infected raccoon dog were inserted into a 50-ml catheter tip-type syringe...
January 26, 2017: Parasitology Research
https://www.readbyqxmd.com/read/28117946/clearance-of-plasma-ivermectin-with-single-pass-lipid-dialysis-in-2-dogs
#13
Leonel A Londoño, Gareth J Buckley, Luiz Bolfer, Carsten Bandt
OBJECTIVE: To describe the use of single pass lipid dialysis (SPLD) for treatment of ivermectin toxicosis in 2 Australian Shepherd dogs with the ABCB1-1Δ gene mutation. CASE SERIES SUMMARY: Two Australian Shepherd dogs were presented for treatment of ivermectin toxicosis. Dogs were initially treated with intravenous lipid emulsion and supportive care, without improvement of clinical signs. They both developed respiratory paralysis and required mechanical ventilation...
January 24, 2017: Journal of Veterinary Emergency and Critical Care
https://www.readbyqxmd.com/read/28117596/factors-affecting-onchocerciasis-transmission-lessons-for-infection-control
#14
Robert A Cheke
Onchocerca volvulus infects in excess of 15 million people. The vectors are Simulium blackflies, varieties of which differ in their ecologies, behaviour and vectorial abilities. Control of the vectors and mass administrations of ivermectin have succeeded in reducing prevalences with elimination achieved in some foci, particularly in Central and southern America. In Africa, progress towards elimination has been less successful. Areas covered: Even with community directed treatment with ivermectin (CDTI), control has been difficult in African areas with initial prevalences in excess of 55%, especially if only annual treatments are dispensed...
January 24, 2017: Expert Review of Anti-infective Therapy
https://www.readbyqxmd.com/read/28115181/resistant-nematodes-in-cattle-pharmaco-therapeutic-assessment-of-the-ivermectin-ricobendazole-combination
#15
Candela Canton, Laura Ceballos, César Fiel, Laura Moreno, Pablo Domingo Yagüez, Gisele Bernat, Carlos Lanusse, Luis Alvarez
Nematodicidal combinations have been proposed as a valid strategy to achieve effective nematode control in the presence of drug resistance. The goals of this study were: (1) to compare the clinical efficacy (therapeutic response) of ivermectin (IVM) and ricobendazole (RBZ) given subcutaneously either by separate or combined administration to calves naturally infected with gastrointestinal nematodes resistant to IVM, and (2) to evaluate the potential pharmacokinetic (PK) and/or pharmacodynamic (PD) interactions occurring after the co-administration of both anthelmintics...
January 30, 2017: Veterinary Parasitology
https://www.readbyqxmd.com/read/28114304/modelling-anti-ov16-igg4-antibody-prevalence-as-an-indicator-for-evaluation-and-decision-making-in-onchocerciasis-elimination-programmes
#16
Yvonne L Lont, Luc E Coffeng, Sake J de Vlas, Allison Golden, Tala de Los Santos, Gonzalo J Domingo, Wilma A Stolk
BACKGROUND: Onchocerciasis is targeted for elimination in Africa through annual or biannual ivermectin mass drug administration (MDA). An immunodiagnostic test, based on the detection of human IgG4 antibodies in the blood to the Onchocerca volvulus-specific antigen Ov16, is one of the recommended tools for determining whether transmission is interrupted and mass treatment can stop. For different transmission settings, the relationship between post-MDA Ov16 antibody prevalence in children (measured 1 year after the last round of MDA) and the duration and coverage of MDA, the mf prevalence in the population, and the probability that onchocerciasis is eventually eliminated is explored through mathematical modelling...
January 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28112345/-pulmonary-strongyloidiasis
#17
Heiler Lozada, Jorge E Daza
Strongyloidiasis is an infection caused by the parasite Strongyloides stercoralis, which can be asymptomatic and means a high morbidity and mortality in immunocompromised hosts, severe malnutrition and coinfection with HTLV-1 virus. The parasite has the potential to produce and multiply internal autoinfection in humans, thus an hyperinfection can be developed. A case of pulmonary infection by this parasite is presented in this study, infection which advanced into a respiratory failure and required mechanical ventilation and hemodynamic support in an intensive care unit...
October 2016: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
https://www.readbyqxmd.com/read/28101647/a-real-time-pcr-approach-to-identify-anthelmintic-resistant-nematodes-in-sheep-farms
#18
M Milhes, M Guillerm, M Robin, M Eichstadt, C Roy, C Grisez, F Prévot, E Liénard, E Bouhsira, M Franc, P Jacquiet
Resistance to fenbendazole, ivermectin, and moxidectin was explored by a fecal egg count reduction test in four meat sheep flocks in southwestern France where anthelmintic resistance was suspected. The FECR test results of the present study confirmed the presence of benzimidazole resistance in three out of the four farms and the presence of ivermectin resistance in one flock. In addition, a suspicion of moxidectin resistance was shown in this latter farm. Both conventional morphological and molecular identifications were performed on larval cultures before and after the treatment in the studied farms...
January 18, 2017: Parasitology Research
https://www.readbyqxmd.com/read/28095895/genome-wide-snp-analysis-using-2b-rad-sequencing-identifies-the-candidate-genes-putatively-associated-with-resistance-to-ivermectin-in-haemonchus-contortus
#19
Xiaoping Luo, Xiaona Shi, Chunxiu Yuan, Min Ai, Cheng Ge, Min Hu, Xingang Feng, Xiaoye Yang
BACKGROUND: The excessive and uncontrolled use of anthelmintics, e.g. ivermectin (IVM) for the treatment of livestock parasites has led to widespread resistance in gastrointestinal nematodes, such as Haemonchus contortus. There is an urgent need for better management of drug-use in nematode control and development of novel anthelmintics. Discovery and identification of anthelmintic resistance-associate molecules/markers can provide a basis for rational anthelmintics-use and development of novel drugs...
January 17, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28093773/establishment-of-a-cell-line-for-assessing-drugs-as-canine-p-glycoprotein-substrates-proof-of-principle
#20
K L Mealey, S Dassanayake, N S Burke
P-glycoprotein (P-gp), encoded by the ABCB1 (MDR1) gene, dramatically impacts drug disposition. P-gp is expressed in the intestines, biliary canaliculi, renal tubules, and brain capillaries where it functions to efflux substrate drugs. In this capacity, P-gp restricts oral absorption, enhances biliary and renal excretion, and inhibits central nervous system entry of substrate drugs. Many drugs commonly used in veterinary medicine are known substrates for canine P-gp (vincristine, loperamide, ivermectin, others)...
January 17, 2017: Journal of Veterinary Pharmacology and Therapeutics
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