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https://www.readbyqxmd.com/read/28101647/a-real-time-pcr-approach-to-identify-anthelmintic-resistant-nematodes-in-sheep-farms
#1
M Milhes, M Guillerm, M Robin, M Eichstadt, C Roy, C Grisez, F Prévot, E Liénard, E Bouhsira, M Franc, P Jacquiet
Resistance to fenbendazole, ivermectin, and moxidectin was explored by a fecal egg count reduction test in four meat sheep flocks in southwestern France where anthelmintic resistance was suspected. The FECR test results of the present study confirmed the presence of benzimidazole resistance in three out of the four farms and the presence of ivermectin resistance in one flock. In addition, a suspicion of moxidectin resistance was shown in this latter farm. Both conventional morphological and molecular identifications were performed on larval cultures before and after the treatment in the studied farms...
January 18, 2017: Parasitology Research
https://www.readbyqxmd.com/read/28095895/genome-wide-snp-analysis-using-2b-rad-sequencing-identifies-the-candidate-genes-putatively-associated-with-resistance-to-ivermectin-in-haemonchus-contortus
#2
Xiaoping Luo, Xiaona Shi, Chunxiu Yuan, Min Ai, Cheng Ge, Min Hu, Xingang Feng, Xiaoye Yang
BACKGROUND: The excessive and uncontrolled use of anthelmintics, e.g. ivermectin (IVM) for the treatment of livestock parasites has led to widespread resistance in gastrointestinal nematodes, such as Haemonchus contortus. There is an urgent need for better management of drug-use in nematode control and development of novel anthelmintics. Discovery and identification of anthelmintic resistance-associate molecules/markers can provide a basis for rational anthelmintics-use and development of novel drugs...
January 17, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28093773/establishment-of-a-cell-line-for-assessing-drugs-as-canine-p-glycoprotein-substrates-proof-of-principle
#3
K L Mealey, S Dassanayake, N S Burke
P-glycoprotein (P-gp), encoded by the ABCB1 (MDR1) gene, dramatically impacts drug disposition. P-gp is expressed in the intestines, biliary canaliculi, renal tubules, and brain capillaries where it functions to efflux substrate drugs. In this capacity, P-gp restricts oral absorption, enhances biliary and renal excretion, and inhibits central nervous system entry of substrate drugs. Many drugs commonly used in veterinary medicine are known substrates for canine P-gp (vincristine, loperamide, ivermectin, others)...
January 17, 2017: Journal of Veterinary Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28078983/cutaneous-larva-migrans
#4
Alexander K C Leung, Benjamin Barankin, Kam Lun Hon
BACKGROUND: Cutaneous larva migrans is one of the most common skin diseases reported in travelers returning from tropical regions. Western physicians, however, are often not familiar of this condition. OBJECTIVE: To review in depth the epidemiology, pathophysiology, clinical manifestations, complications, and treatment of cutaneous larva migrans. METHODS: A PubMed search was completed in Clinical Queries using the key term "cutaneous larva migrans"...
January 10, 2017: Recent Patents on Inflammation & Allergy Drug Discovery
https://www.readbyqxmd.com/read/28067137/residue-depletion-of-ivermectin-in-broiler-poultry
#5
Nora Mestorino, Daniel Buldain, Andrea Buchamer, Lihuel Gortari, Martín Daniele, María Laura Marchetti
Helminth infections are widespread in the poultry industry. There is evidence of extra-label use of some drugs, such as ivermectin (IVM) in broiler poultry. Pharmacokinetic and residual studies of IVM in poultry, however, are rather scarce. Our aim was to determine time restrictions for broiler chickens fed with balanced feed mixed with IVM for 21 days, could be in acceptable residual levels for consumption as established by the EU. Sixty 1-day old chicks were fed with food supplemented with IVM at 5 mg/kg feed for 21 days...
January 9, 2017: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
https://www.readbyqxmd.com/read/28065670/oral-slow-release-ivermectin-biting-back-at-malaria-vectors
#6
Carlos J Chaccour, N Regina Rabinovich
Bellinger and colleagues offer an elegant twist for a promising new tool against malaria. This formulation is designed to release ivermectin, a mosquito-killing drug for 10 days after a single oral dose. This could reduce the vector population and serve as a complementary tool for malaria elimination.
January 5, 2017: Trends in Parasitology
https://www.readbyqxmd.com/read/28063594/-scabies-of-the-nail-unit-in-an-infant
#7
A Finon, G Desoubeaux, M Nadal, G Georgescou, R Baran, A Maruani
BACKGROUND: There are no guidelines regarding the management of scabies in infants and recurrence is common at this age. We report the case of an infant with subungual hyperkeratosis and ungual lesions subsequent to classic scabies. PATIENTS AND METHODS: A 7-month-girl, treated 6 weeks earlier with esdepallethrin for scabies, consulted for acquired lesions on 3 toe nails. These nails were thickened and displayed subungual hyperkeratosis. Physical examination of the skin, the finger nails and mucous membranes was otherwise normal...
January 4, 2017: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/28062820/epidemiology-diagnosis-and-treatment-of-scabies-in-a-dermatology-office
#8
Kathryn L Anderson, Lindsay C Strowd
BACKGROUND: Scabies is a neglected skin disease, and little is known about current incidence and treatment patterns in the United States. The purpose of this study was to examine demographic data, treatment types, success of treatment, and misdiagnosis rate of scabies in an outpatient dermatology clinic. METHODS: A retrospective chart review of patients diagnosed with scabies within the past 5 years was performed. RESULTS: A total of 459 charts were identified, with 428 meeting inclusion criteria...
January 2017: Journal of the American Board of Family Medicine: JABFM
https://www.readbyqxmd.com/read/28061549/fast-and-simple-detection-methods-for-the-4-base-pair-deletion-of-canine-mdr1-abcb1-gene-by-pcr-and-isothermal-amplification
#9
Cathrin P Stiedl, Karin Weber
Dogs with a 4-bp deletion in the MDR1 (or ABCB1) gene show intolerance to certain drugs routinely used in veterinary medicine, such as ivermectin, vincristine, and doxorubicin. The mutation leads to a dysfunctional P-glycoprotein drug transporter, which results in drug accumulation in the brain and severe neurotoxicity. A rapid and accurate in-house test to determine the genotype of patients in cases of acute neurotoxic signs or in tumor patients is desirable. We describe a cost-effective detection method with simple technical equipment for veterinary practice...
January 1, 2017: Journal of Veterinary Diagnostic Investigation
https://www.readbyqxmd.com/read/28056015/potential-value-of-triple-drug-therapy-with-ivermectin-diethylcarbamazine-and-albendazole-ida-to-accelerate-elimination-of-lymphatic-filariasis-and-onchocerciasis-in-africa
#10
Peter U Fischer, Christopher L King, Julie A Jacobson, Gary J Weil
No abstract text is available yet for this article.
January 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28052336/topical-ivermectin-improves-allergic-skin-inflammation
#11
Erwan Ventre, Aurore Rozières, Vanina Lenief, Floriane Albert, Patricia Rossio, Léo Laoubi, David Dombrowicz, Bart Staels, Lauriane Ulmann, Valerie Julia, Emmanuel Vial, André Jomard, Fériel Hacini-Rachinel, Jean-François Nicolas, Marc Vocanson
BACKGROUND: Ivermectin (IVM) is widely used in both human and veterinary medicine to treat parasitic infections. Recent reports have suggested that IVM could also have anti-inflammatory properties. METHODS: Here, we investigated the activity of IVM in a murine model of atopic dermatitis (AD) induced by repeated exposure to the allergen Dermatophagoides farinae, and in standard cellular immunology assays. RESULTS: Our results show that topical IVM improved allergic skin inflammation by reducing the priming and activation of allergen-specific T cells, as well as the production of inflammatory cytokines...
January 4, 2017: Allergy
https://www.readbyqxmd.com/read/28052193/distribution-of-animal-drugs-among-curd-whey-and-milk-protein-fractions-in-spiked-skim-milk-and-whey
#12
Nancy W Shappell, Weilin L Shelver, Sara J Lupton, Wendy Fanaselle, Jane M Van Doren, Heldur Hakk
It is important to understand the partitioning of drugs in processed milk and milk products, when drugs are present in raw milk, in order to estimate the potential consumer exposure. Radioisotopically labelled erythromycin, ivermectin, ketoprofen, oxytetracycline, penicillin G, sulfadimethoxine, and thiabendazole were used to evaluate the distribution of animal drugs among rennet curd, whey, and protein fractions from skim cow milk. Our previous work reported the distribution of these same drugs between skim and fat fractions of milk...
January 4, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28043394/first-documentation-of-ivermectin-resistance-in-rhipicephalus-sanguineus-sensu-lato-acari-ixodidae
#13
R I Rodriguez-Vivas, M M Ojeda-Chi, I Trinidad-Martinez, A A Pérez de León
: The brown dog tick, Rhipicephalus sanguineus sensu lato (Latreille, 1806), is an ectoparasite and disease vector of significant veterinary and public health importance that is distributed widely around the world. The intensive use of synthetic acaricides for tick control exerts a strong selective pressure for brown dog ticks to become resistant to them. Here, we investigated claims from the field regarding treatment failure associated with the use of veterinary products containing ivermectin (IVM) to control brown dog ticks infesting dogs in Yucatan state, Mexico...
January 15, 2017: Veterinary Parasitology
https://www.readbyqxmd.com/read/28034767/interruption-of-the-transmission-of-onchocerca-volvulus-in-the-kashoya-kitomi-focus-western-uganda-by-long-term-ivermectin-treatment-and-elimination-of-the-vector-simulium-neavei-by-larviciding
#14
T Lakwo, R Garms, J Wamani, E M Tukahebwa, E Byamukama, A W Onapa, E Tukesiga, J Katamanywa, S Begumisa, P Habomugisha, D Oguttu, E Byamukama, F Richards, T R Unnasch, M Katabarwa
Uganda is the only country in sub-Saharan Africa whose onchocerciasis elimination programme extensively uses vector control and biannual treatment with ivermectin. The purpose of this study was to assess the impact of combined strategies on interrupting onchocerciasis transmission in the Kashoya-Kitomi focus. Mass Drug Administration annually (13 years) followed by biannual treatments (6 years) and ground larviciding (36 cycles in 3 years) with temephos (Abate(®), EC500) against Simulium neavei were conducted...
December 26, 2016: Acta Tropica
https://www.readbyqxmd.com/read/28031202/slow-release-ivermectin-formulation-for-malaria-control-a-pilot-study-in-80-kg-pigs
#15
Carlos Chaccour, Gloria Abizanda, Ángel Irigoyen, José Luis Del Pozo
Vector control with long-lasting insecticidal nets (LLINs) and indoor residual spraying are responsible for more than two thirds of the reduction seen in malaria prevalence in Africa over the last 15 years (1).….
December 28, 2016: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28012943/effectiveness-of-a-triple-drug-regimen-for-global-elimination-of-lymphatic-filariasis-a-modelling-study
#16
Michael A Irvine, Wilma A Stolk, Morgan E Smith, Swaminathan Subramanian, Brajendra K Singh, Gary J Weil, Edwin Michael, T Deirdre Hollingsworth
BACKGROUND: Lymphatic filariasis is targeted for elimination as a public health problem by 2020. The principal approach used by current programmes is annual mass drug administration with two pairs of drugs with a good safety profile. However, one dose of a triple-drug regimen (ivermectin, diethylcarbamazine, and albendazole) has been shown to clear the transmissible stage of the helminth completely in treated individuals. The aim of this study was to use modelling to assess the potential value of mass drug administration with the triple-drug regimen for accelerating elimination of lymphatic filariasis in different epidemiological settings...
December 21, 2016: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/28012111/automated-thin-film-microextraction-coupled-to-a-flow-through-cell-somewhere-in-between-passive-and-active-sampling
#17
Manuel Wohde, Jens-Ole Bartz, Leonard Böhm, Christoph Hartwig, Benjamin Martin Keil, Katharina Martin, Rolf-Alexander Düring
A prototype for the automated thin-film microextraction of pharmaceuticals from aqueous solutions has been developed and is presented here for the first time. With a software-controlled setup, extraction methods for ivermectin and iohexol have been developed. The widely used antiparasitic agent ivermectin is non-polar and has a high tendency to sorb to surfaces. In contrast to this, the nonionic but polar iodinated X-ray contrast agent iohexol is freely water soluble. With these two substances, a wide range of polarity is covered...
December 23, 2016: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/27998311/disseminated-tungiasis-in-a-78-year-old-woman-from-tanzania-a-case-report
#18
Pedro Pallangyo, Paulina Nicholaus
BACKGROUND: Tungiasis is one of the neglected tropical diseases; it affects up to 40% of individuals living in societies with poor housing and sanitation standards. In endemic areas, Tunga infestation, which predominantly affects the periungual areas of the lower limbs in humans, is associated with considerable morbidity and poor quality of life. CASE PRESENTATION: A 78-year-old woman of African descent presented with pain, inflammation, suppuration, ulceration, and deformation of digits of all four limbs...
December 20, 2016: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/27992424/the-impact-of-lymphatic-filariasis-mass-drug-administration-scaling-down-on-soil-transmitted-helminth-control-in-school-age-children-present-situation-and-expected-impact-from-2016-to-2020
#19
Denise Mupfasoni, Antonio Montresor, Alexei Mikhailov, Jonathan King
Lymphatic filariasis (LF) and soil-transmitted-helminths (STH) are co-endemic in 58 countries which are mostly in Africa and Asia. Worldwide, 486 million school-age children are considered at risk of both diseases. In 2000, the World Health Organization (WHO) established the global programme to eliminate LF by 2020. Since then, the LF elimination programme has distributed ivermectin or diethylcarbamazine citrate (DEC) in combination with albendazole, thereby also treating STH. Consequently, many school-age children have been treated for STH through the LF programme...
December 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/27988991/egfri-induced-papulopustular-rosacea-like-rash-successfully-treated-with-topical-ivermectin
#20
S Käser, C Ruini, M Ezmerli, T V Braunmühl, D Hartmann, T Ruzicka, M Reinholz
A 63-year-old Caucasian man presented with a three weeks history of multiple erythematous, rosacea-like, facial and thoracic papules and pustules. No mucosal lesions were present. The patient received a combined therapy for metastatic colon carcinoma with cetuximab 500 mg/m²/week plus capecitabine 500 mg/week; just after the onset he developed the papulopustular rash first on his face with subsequent expansion to the thorax (figure 1, A, B). This article is protected by copyright. All rights reserved.
December 18, 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
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