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https://www.readbyqxmd.com/read/29774301/-mansonella-perstans-onchocerca-volvulus-and-strongyloides-stercoralis-infections-in-rural-populations-in-central-and-southern-togo
#1
Francois Korbmacher, Kossi Komlan, Richard G Gantin, Wiyao P Poutouli, Koffi Padjoudoum, Potchoziou Karabou, Peter T Soboslay, Carsten Köhler
Background: Mansonella perstans , Onchocerca volvulus and Strongyloides stercoralis are widespread helminth parasites in the tropics. Their distribution remains difficult to determine as it may change during national disease control programs and with regional mass drug administration (MDA). Epidemiological surveys are of importance to evaluate the geographical distribution of these helminth parasites and the diseases they may cause, however, up to date epidemiological evaluations on M...
May 2018: Parasite Epidemiology and Control
https://www.readbyqxmd.com/read/29774296/integrated-risk-mapping-and-landscape-characterisation-of-lymphatic-filariasis-and-loiasis-in-south-west-nigeria
#2
Tara A Brant, Patricia N Okorie, Olushola Ogunmola, Nureni Bolaji Ojeyode, S B Fatunade, Emmanuel Davies, Yisa Saka, Michelle C Stanton, David H Molyneux, J Russell Stothard, Louise A Kelly-Hope
Nigeria has the heaviest burden of lymphatic filariasis (LF) in sub-Saharan Africa, which is caused by the parasite Wuchereria bancrofti and transmitted by Anopheles mosquitoes. LF is targeted for elimination and the national programme is scaling up mass drug administration (MDA) across the country to interrupt transmission. However, in some regions the co-endemicity of the filarial parasite Loa loa (loiasis) is an impediment due to the risk of severe adverse events (SAEs) associated with the drug ivermectin...
February 2018: Parasite Epidemiology and Control
https://www.readbyqxmd.com/read/29774284/rapid-integrated-clinical-survey-to-determine-prevalence-and-co-distribution-patterns-of-lymphatic-filariasis-and-onchocerciasis-in-a-loa-loa-co-endemic-area-the-angolan-experience
#3
Miguel Brito, Rossely Paulo, Pedro Van-Dunem, António Martins, Thomas R Unnasch, Robert J Novak, Benjamin Jacob, Michelle C Stanton, David H Molyneux, Louise A Kelly-Hope
The Republic of Angola is a priority country for onchocerciasis and lymphatic filariasis (LF) elimination, however, the co-distribution of the filarial parasite Loa loa (loiasis) is a significant impediment, due to the risk of severe adverse events (SAEs) associated with ivermectin used in mass drug administration (MDA) campaigns. Angola has a high risk loiasis zone identified in Bengo Province where alternative interventions may need to be implemented; however, the presence and geographical overlap of the three filarial infections/diseases are not well defined...
August 2017: Parasite Epidemiology and Control
https://www.readbyqxmd.com/read/29771941/efficacy-of-ivermectin-mass-drug-administration-to-control-scabies-in-asylum-seekers-in-the-netherlands-a-retrospective-cohort-study-between-january-2014-march-2016
#4
Dorien T Beeres, Sofanne J Ravensbergen, Annelies Heidema, Darren Cornish, Machiel Vonk, Leonie D Wijnholds, Jessica J H Hendriks, Johanneke Kleinnijenhuis, Till F Omansen, Ymkje Stienstra
Scabies is a skin infestation with the mite Sarcoptes scabiei causing itch and rash and is a major risk factor for bacterial skin infections and severe complications. Here, we evaluated the treatment outcome of 2866 asylum seekers who received (preventive) scabies treatment before and during a scabies intervention programme (SIP) in the main reception centre in the Netherlands between January 2014 and March 2016. A SIP was introduced in the main national reception centre based on frequent observations of scabies and its complications amongst Eritrean and Ethiopian asylum seekers in the Netherlands...
May 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29768412/adverse-events-following-single-dose-treatment-of-lymphatic-filariasis-observations-from-a-review-of-the-literature
#5
Philip J Budge, Carly Herbert, Britt Andersen, Gary J Weil
BACKGROUND: WHO's Global Programme to Eliminate Lymphatic Filariasis (LF) uses mass drug administration (MDA) of anthelmintic medications to interrupt LF transmission in endemic areas. Recently, a single dose combination of ivermectin (IVM), diethylcarbamazine (DEC), and albendazole (ALB) was shown to be markedly more effective than the standard two-drug regimens (DEC or IVM, plus ALB) for achieving long-term clearance of microfilaremia. OBJECTIVE AND METHODS: To provide context for the results of a large-scale, international safety trial of MDA using triple drug therapy, we searched Ovid Medline for studies published from 1985-2017 that reported adverse events (AEs) following treatment of LF with IVM, DEC, ALB, or any combination of these medications...
May 16, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29761763/in-southern-nigeria-loa-loa-blood-microfilaria-density-is-very-low-even-in-areas-with-high-prevalence-of-loiasis-results-of-a-survey-using-the-new-loascope-technology
#6
Emmanuel Emukah, Lindsay J Rakers, Barminas Kahansim, Emmanuel S Miri, Bertram E B Nwoke, Emily Griswold, Yisa Saka, Ifeoma Anagbogu, Emmanuel Davies, Cephas Ityonzughul, Michael D'Ambrosio, Matthew Bakalar, Daniel A Fletcher, Thomas Nutman, Joseph Kamgno, Frank O Richards
Ivermectin treatment can cause central nervous system adverse events (CNS-AEs) in persons with very high-density Loa loa microfilaremia (≥ 30,000 mf/mL blood). Hypoendemic onchocerciasis areas where L. loa is endemic have been excluded from ivermectin mass drug administration programs (MDA) because of the concern for CNS AEs. The rapid assessment procedure for L. loa (RAPLOA) is a questionnaire survey to assess history of eye worm. If ≥ 40% of respondents report eye worm, this correlates with ≥ 2% prevalence of very high-density loiasis microfilaremia, posing an unacceptable risk of CNS-AEs after MDA...
May 14, 2018: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29758488/genetic-variants-in-dyf-7-validated-by-droplet-digital-pcr-are-not-drivers-for-ivermectin-resistance-in-haemonchus-contortus
#7
Safaa T Elmahalawy, Peter Halvarsson, Moa Skarin, Johan Höglund
Resistance to ivermectin (IVM) in the nematode Haemonchus contortus in small ruminants is an increasing problem throughout the world. Access to molecular diagnostics will allow early detection of IVM resistance, which in turn can limit the spread of resistant isolates. One candidate gene which has recently been suggested as a marker for IVM resistance is that for dye-filling protein (dyf-7). In this study, we critically investigated the suitability of A141G and G153T single nucleotide polymorphisms (SNP) of dyf-7 as a marker in larval cultures collected from sheep farms in Sweden, involving several isolates for which resistance status had been characterised by the faecal egg count reduction test (FECRT)...
April 26, 2018: International Journal for Parasitology, Drugs and Drug Resistance
https://www.readbyqxmd.com/read/29741149/case-report-probable-case-of-spontaneous-encephalopathy-due-to-loiasis-and-dramatic-reduction-of-loa-loa-microfilariaemia-with-prolonged-repeated-courses-of-albendazole
#8
Divine B Arrey-Agbor, Hugues C Nana-Djeunga, Aude E Mogoung-Wafo, Mirabelle Mafo, Christian Danwe, Joseph Kamgno
Loiasis is a vector-borne parasitic disease caused by the filarial nematode Loa loa and transmitted by the tabanid vectors from the genus Chrysops . Loa loa infection is associated with clinical manifestations such as pruritus, migratory transient edema, passage of adult worm in the bulbar conjunctiva, retinal damage, glomerular damage, albuminuria, pleural effusion, hydrocele, and endomyocardial fibrosis. Data reporting the occurrence of spontaneous encephalopathy associated with loiasis are very scanty. Severe adverse events occurring post-ivermectin administered in the framework of the fight against onchocerciasis and/or lymphatic filariasis in loiasis co-endemic areas have been closely associated with very high L...
May 7, 2018: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29735728/the-nicotinic-acetylcholine-receptor-a-typical-allosteric-machine
#9
REVIEW
Jean-Pierre Changeux
The concept of allosteric interaction was initially proposed to account for the inhibitory feedback mechanism mediated by bacterial regulatory enzymes. In contrast with the classical mechanism of competitive, steric, interaction between ligands for a common site, allosteric interactions take place between topographically distinct sites and are mediated by a discrete and reversible conformational change of the protein. The concept was soon extended to membrane receptors for neurotransmitters and shown to apply to the signal transduction process which, in the case of the acetylcholine nicotinic receptor (nAChR), links the ACh binding site to the ion channel...
June 19, 2018: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/29732628/the-comparative-efficacy-of-afoxolaner-spinosad-milbemycin-spinosad-plus-milbemycin-and-nitenpyram-for-the-treatment-of-canine-cutaneous-myiasis
#10
Hock Siew Han, Charles Chen, Carlo Schievano, Chiara Noli
BACKGROUND: Canine screw-worm myiasis due to Cochliomyia hominivorax or Chrysomya bezziana has traditionally been treated with extra-label use of ivermectin. The larvicidal activities of nitenpyram and spinosad/milbemycin also have been described, but there have been no reports to describe the efficacy of isoxazolines such as afoxolaner. OBJECTIVES: To evaluate and compare the efficacy of spinosad, spinosad/milbemycin, milbemycin, nitenpyram and afoxolaner for the treatment of canine screw-worm myiasis...
May 6, 2018: Veterinary Dermatology
https://www.readbyqxmd.com/read/29728135/targeting-cattle-for-malaria-elimination-marked-reduction-of-anopheles-arabiensis-survival-for-over-six-months-using-a-slow-release-ivermectin-implant-formulation
#11
Carlos J Chaccour, Kija Ngha'bi, Gloria Abizanda, Angel Irigoyen Barrio, Azucena Aldaz, Fredros Okumu, Hannah Slater, Jose Luis Del Pozo, Gerry Killeen
BACKGROUND: Mosquitoes that feed on animals can survive and mediate residual transmission of malaria even after most humans have been protected with insecticidal bednets or indoor residual sprays. Ivermectin is a widely-used drug for treating parasites of humans and animals that is also insecticidal, killing mosquitoes that feed on treated subjects. Mass administration of ivermectin to livestock could be particularly useful for tackling residual malaria transmission by zoophagic vectors that evade human-centred approaches...
May 4, 2018: Parasites & Vectors
https://www.readbyqxmd.com/read/29723292/caenorhabditis-elegans-susceptibility-to-daldinia-cf-concentrica-bioactive-volatiles-is-coupled-with-expression-activation-of-the-stress-response-transcription-factor-daf-16-a-part-of-distinct-nematicidal-action
#12
Payal Sanadhya, Patricia Bucki, Orna Liarzi, David Ezra, Abraham Gamliel, Sigal Braun Miyara
The bionematicidal effect of a synthetic volatile mixture (SVM) of four volatile organic compounds (VOCs) emitted by the endophytic fungus Daldinia cf. concentrica against the devastating plant-parasitic root-knot nematode Meloidogyne javanica has been recently demonstrated in both in vitro and greenhouse experiments. However, the mode of action governing the observed irreversible paralysis of J2 larvae upon exposure to SVM is unknown. To unravel the mechanism underlying the anthelmintic and nematicidal activities, we used the tractable model worm Caenorhabditis elegans...
2018: PloS One
https://www.readbyqxmd.com/read/29721288/the-effects-of-food-and-parasitism-on-reproductive-performance-of-a-wild-rodent
#13
Pei-Jen L Shaner, Ai-Yun Yu, Shou-Hsien Li, Ching-Ho Hou
Food and parasitism can have complex effects on small mammal reproduction. In this study, we tested the effects of sex, food, and parasitism on reproductive performance of the Taiwan field mouse ( Apodemus semotus ). In a field experiment, we increased food availability for a portion of the mice in the population by providing sorghum seeds to a set of food stations. We reduced parasite intensity of randomly chosen mice through ivermectin treatment. We determined the number and quality of offspring for the mice using paternity analysis...
April 2018: Ecology and Evolution
https://www.readbyqxmd.com/read/29716644/equine-strongyle-communities-are-constrained-by-horse-sex-and-species-dipersal-fecundity-trade-off
#14
Guillaume Sallé, Sławomir Kornaś, Marta Basiaga
BACKGROUND: Equine strongyles are a major health issue. Large strongyles can cause death of horses while cyathostomins (small strongyles) have shown increased resistance to anthelmintics worldwide. Description of strongyle communities have accumulated but little is known about the diversity of these communities and underpinning environmental factors. METHODS: Strongyles were recovered after ivermectin treatment from 48 horses located in six premises in Poland. Correlation between previously published species fecundity and the observed relative abundance and prevalence were estimated...
May 2, 2018: Parasites & Vectors
https://www.readbyqxmd.com/read/29702653/efficacy-and-safety-of-co-administered-ivermectin-plus-albendazole-for-treating-soil-transmitted-helminths-a-systematic-review-meta-analysis-and-individual-patient-data-analysis
#15
Marta S Palmeirim, Eveline Hürlimann, Stefanie Knopp, Benjamin Speich, Vicente Belizario, Serene A Joseph, Michel Vaillant, Piero Olliaro, Jennifer Keiser
BACKGROUND: The soil-transmitted helminths (STH), Ascaris lumbricoides, Trichuris trichiura and hookworms infect 1.5 billion people worldwide and cause an estimated burden of 3.3 million disability-adjusted life years (DALYs). Current control strategies focus on morbidity reduction through preventive chemotherapy (PC) but the most commonly used recommended drugs (albendazole and mebendazole) are particularly inefficacious against T. trichiura. This, together with the threat of emerging drug resistance, calls for new control strategies, including co-administration with other anthelminthics...
April 27, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29695450/case-series-periocular-habronemiasis-in-five-horses-in-the-netherlands
#16
Nicole Verhaar, Hanneke Hermans, Eugene van Rooij, Marianne Sloet van Oldruitenborgh-Oosterbaan, Jos Ensink
In tropical and subtropical climates, infection of periocular tissue by Habronema larvae is a recognised cause of conjunctivitis or blepharitis. To the authors' knowledge, only a few cases of habronemiasis have been described in Western Europe, and it has not been documented previously in the Netherlands. The objective of this report is to describe the occurrence of five cases of (peri)ocular habronemiasis in the Netherlands, of which four date from the past few years. The diagnosis was based on the history, clinical signs and histopathologic examination of biopsy specimens...
April 25, 2018: Veterinary Record
https://www.readbyqxmd.com/read/29690907/elimination-of-onchocerciasis-in-ecuador-findings-of-post-treatment-surveillance
#17
Ángel Guevara, Raquel Lovato, Roberto Proaño, Mario A Rodriguez-Perez, Thomas Unnasch, Philip J Cooper, Ronald H Guderian
BACKGROUND: The Esmeraldas focus of onchocerciasis in Ecuador expanded geographically during the 1980s and was associated with severe ocular and skin disease. Mass drug administration (MDA) with ivermectin started in 1991, initially once but later twice a year, in the principle endemic focus followed by all satellite foci. Treatment was stopped in 2009 when entomological assessments determined that transmission of Onchocerca volvulus had been interrupted. METHODS: Three years after the cessation of ivermectin treatment in 2012, as defined by the WHO guidelines for onchocerciasis elimination, blackfly collections were done in four sentinel sites in former hyperendemic areas...
April 24, 2018: Parasites & Vectors
https://www.readbyqxmd.com/read/29684817/avermectin-toxicity-in-bovines-less-than-thirty-days-old
#18
Daniel de Castro Rodrigues, Carolina Buzullini, Tiago Arantes Pereira, Breno Cayeiro Curz, Lucas Vinicius Costa Gomes, Vando Edésio Soares, Thiago Souza Azeredo Bastos, Luiz Fellipe Monteiro Couto, Welber Daniel Zanetti Lopes, Gilson Pereira de Oliveira, Alvimar José da Costa
The present study was designed to evaluate possible adverse effects of different dosages of avermectins (abamectin and a combination of ivermectin + abamectin) administered subcutaneously in calves less than one month of age. Clinical as well as biochemical parameters of blood and cerebrospinal fluid (CSF) were evaluated for animals subjected to various treatments. Thirty-five calves were divided into seven groups of five animals each: T01 (control), T02 (abamectin 200 μg/kg), T03 (abamectin 400 μg/kg), T04 (abamectin 600 μg/kg), T05 (ivermectin 450 μg/kg + abamectin 250 μg/kg), T06 (ivermectin 900 μg/kg + abamectin 500 μg/kg) and T07 (ivermectin 1350 μg/kg + abamectin 750 μg/kg)...
April 16, 2018: Research in Veterinary Science
https://www.readbyqxmd.com/read/29671119/potential-risks-of-dietary-exposure-to-chlorpyrifos-and-cypermethrin-from-their-use-in-fruit-vegetable-crops-and-beef-cattle-productions
#19
Daniela M Ferré, Arnoldo A M Quero, Antonio F Hernández, Valentina Hynes, Marcelo J Tornello, Carlos Lüders, Nora B M Gorla
The active ingredients (a.i.) used as pesticides vary across regions. Diet represents the main source of chronic exposure to these chemicals. The aim of this study was to look at the pesticides applied in fruit, vegetable, and beef cattle productions in Mendoza (Argentina), to identify those that were simultaneously used by the three production systems. Local individuals (n = 160), involved in these productions, were interviewed. Glyphosate was the a.i. most often used by fruit-vegetable producers, and ivermectin by beef cattle producers...
April 18, 2018: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/29663166/anthelmintic-efficacy-of-glycolipid-biosurfactant-produced-by-pseudomonas-plecoglossicida-an-insight-from-mutant-and-transgenic-forms-of-caenorhabditis-elegans
#20
Sabarinathan Devaraj, Mohankumar Amirthalingam, Poorna Chandrika Sabapathy, Shanmugam Govindan, Sundararaj Palanisamy, Preethi Kathirvel
The current research focuses on the production and characterization of glycolipid biosurfactant (GB) from Pseudomonas plecoglossicida and its anthelmintic activity against Caenorhabditis elegans. The GB was purified and characterized by Fourier Transform Infrared Spectroscopy (FTIR) and Gas Chromatography and Mass Spectrometry (GC-MS) analysis. Anthelmintic activity of GB was studied at six different pharmacological doses from 10 to 320 µg/mL on C. elegans. Exposure of different developmental stages (L1, L2, L3, L4 and adult) of C...
April 16, 2018: Biodegradation
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