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Cutaneous lupus

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https://www.readbyqxmd.com/read/29050884/initial-digital-vasculitis-in-a-large-multicenter-cohort-of-childhood-onset-systemic-lupus-erythematosus
#1
Ana Paula Sakamoto, Clovis Artur Silva, Marco Felipe Castro da Silva, Anandreia Simões Lopes, Gleice Clemente Souza Russo, Adriana Maluf Elias Sallum, Katia Kozu, Eloisa Bonfá, Claudia Saad-Magalhães, Rosa Maria Rodrigues Pereira, Claudio Arnaldo Len, Maria Teresa Terreri
OBJECTIVES: To assess clinical digital vasculitis (DV) as an initial manifestation of childhood-onset systemic lupus erythematosus (cSLE) within a large population. METHODS: Multicenter cross-sectional study including 852 cSLE patients (ACR criteria) followed in ten Pediatric Rheumatology centers in São Paulo State, Brazil. RESULTS: DV was observed in 25/852 (3%) cSLE patients. Periungual hemorrhage was diagnosed in 12 (48%), periungual infarction in 7 (28%), tip finger ulceration in 4 (16%), painful nodules in 1 (4%) and gangrene in 1 (4%)...
October 16, 2017: Revista Brasileira de Reumatologia
https://www.readbyqxmd.com/read/29049558/from-paris-to-vienna-the-varied-names-and-descriptions-of-cutaneous-lupus-erythematosus-in-the-19th-century
#2
Connie R Shi, Peter H Schur, Vinod E Nambudiri
No abstract text is available yet for this article.
October 1, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/29049207/cutaneous-mucormycosis-in-a-patient-with-lupus-nephritis-a-case-report-and-review-of-literature
#3
Wenrong Cheng, Guoqin Wang, Min Yang, Lijun Sun, Hongrui Dong, Yipu Chen, Hong Cheng
RATIONALE: Mucormycosis is a rare fungal infection but life-threatening, especially in lupus nephritis (LN). Mucormycosis may manifest as rhino-orbital-cerebral, pulmonary, cutaneous, gastrointestinal, renal, or disseminated forms. PATIENT CONCERNS: We report a case of a 52-year-old woman with cutaneous mucormycosis infection who was admitted because of LN. DIAGNOSES: Histopathological analysis of the lesion confirmed the Rhizopus microspores from the family Mucoraceae...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29028121/lupus-like-cutaneous-reaction-following-pembrolizumab-an-immune-related-adverse-event-associated-with-anti-pd-1-therapy
#4
Kimberly Shao, Suzanne McGettigan, Rosalie Elenitsas, Emily Y Chu
PD-1 (programmed cell death-1) inhibitors, used to treat metastatic melanoma and other malignancies, are associated with development of immune-related adverse events in the skin. Such reactions include morbilliform eruptions, vitiligo, alopecia areata, and bullous pemphigoid. In this report, we describe a patient who developed a lupus-like cutaneous reaction in the setting of pembrolizumab therapy for metastatic melanoma, adding to the spectrum of reactions which may be observed in association with PD-1 inhibitor therapy...
October 13, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/29021537/elevated-levels-of-ccr6-t-helper-22-cells-correlate-with-skin-and-renal-impairment-in-systemic-lupus-erythematosus
#5
Wei Zhong, Yanfang Jiang, Hongshuang Ma, Jiang Wu, Zhenyu Jiang, Ling Zhao
Systemic lupus erythematosus (SLE) is an autoimmune disease with a variety of pathological features. Our study investigated the potential role of CCR6(+) T cells in organ impairment of SLE patients. We analyzed CCR6(+/-) T cell subset populations and compared the concentrations of IL-22, IFN-γ, TNF-α, and IL-17A cytokines in 67 patients with newly diagnosed SLE and 26 healthy controls. We found that SLE patients had elevated percentages of CCR6(+) T, CCR6(+) Th22, Th17, Th17.1, and CCR6(-) Th2 cell subsets, along with increased concentrations of IL-22, IFN-γ, TNF-α, and IL-17 cytokines...
October 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28992799/significant-symptomatic-improvement-of-subacute-cutaneous-lupus-after-testosterone-therapy-in-a-female-to-male-transgender-subject
#6
A Ocon, R Peredo-Wende, J M Kremer, B D Bhatt
No abstract text is available yet for this article.
January 1, 2017: Lupus
https://www.readbyqxmd.com/read/28989111/efficacy-and-tolerance-profile-of-thalidomide-in-cutaneous-lupus-erythematosus-a-systematic-review-and-meta-analysis
#7
François Chasset, Toufik Tounsi, Elise Cesbron, Annick Barbaud, Camille Francès, Laurent Arnaud
BACKGROUND: Thalidomide has shown excellent results for severe cutaneous lupus Erythematosus (CLE) but its prescription is limited by potentially severe adverse events. OBJECTIVES: To assess the overall response rate of thalidomide in CLE with respect to CLE subtypes and the occurrence rate of relevant adverse events based on previously published studies. METHODS: We performed a systematic review and meta-analysis of studies published in MEDLINE, Embase, Cochrane library between 1965 and January 2017...
October 5, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28989103/antimalarial-drug-toxicities-in-patients-with-cutaneous-lupus-and-dermatomyositis-a-retrospective-cohort-study
#8
Lavanya Mittal, Lingqiao Zhang, Rui Feng, Victoria P Werth
BACKGROUND: Although existing evidence demonstrates the efficacy of antimalarials for rheumatic skin disease, the safety of these medications, and particularly quinacrine, remain debated. OBJECTIVE: We investigate the toxicity risk associated with antimalarials in patients with cutaneous lupus erythematosus (CLE) and dermatomyositis (DM). METHODS: 532 patients (Mean age=52.29 years, Female=85.15%, Male=14.85%) were selected from two databases of CLE (69...
October 5, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28984923/b-cell-tolerance-to-epidermal-ribonuclear-associated-neo-autoantigen-in-vivo
#9
Søren E Degn, Elisabeth Alicot, Michael C Carroll
Defining how self-antigens are perceived by the immune system is pivotal to understand how tolerance is maintained under homeostatic conditions. Clinically relevant, natural autoantigens targeted by autoantibodies in e.g. systemic lupus erythematosus (SLE) commonly have an intrinsic ability to engage not only the B cell receptor (BCR), but also a costimulatory pathway in B cells, such as the TLR7 pathway. Here we developed a novel mouse model displaying inducible expression of a fluorescent epidermal neo-autoantigen carrying an OT-II T cell epitope, B cell antigen, and associated ribonucleic acids capable of stimulating TLR7...
October 6, 2017: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/28961286/asymptomatic-cutaneous-polyarteritis-nodosa-treatment-options-and-therapeutic-guidelines
#10
Kate Ross, Jessika Contreras, David Aung-Din, Mary Lien
Cutaneous polyarteritis nodosa (CPAN) is a rare cutaneous small- to medium-vessel vasculitis of unknown etiology. Clinically it ranges in manifestation from livedo reticularis to large cutaneous ulcers and necrosis. Prognosis is favorable and progression to systemic polyarteritis nodosa is rare. There are multiple treatment options, none of which have proven to be definitively effective. Cutaneous polyarteritis nodosa has been associated with abnormal antibody testing with elevations of antiphospholipid cofactor antibody, lupus anticoagulant, anticardiolipin antibody, and anti-β2-glycoprotein I-dependent cardiolipin antibodies, as well as elevated anti-phosphatidylserine-prothrombin complex antibody...
August 2017: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/28943504/chronic-cutaneous-lupus-erythematosus-revealed-by-unilateral-eyelid-oedema
#11
Ioanna Yfanti, Marie Paule Guillaume, Ursula Sass, Athanassios Kolivras
No abstract text is available yet for this article.
September 23, 2017: European Journal of Dermatology: EJD
https://www.readbyqxmd.com/read/28941499/genomic-investigation-of-lupus-in-the-skin
#12
REVIEW
Animesh A Sinha, Rama Dey-Rao
Lupus erythematosus is a chronic autoimmune disorder with a protean clinical manifestation affecting virtually every organ including skin, with tremendous variation between patients. This makes it vital to stratify patients on a molecular basis. We used gene microarray technology for large-scale screening combined with bioinformatics to investigate global patterns of gene expression in cutaneous lupus erythematosus to allow further insights into disease heterogeneity. Unbiased clustering exposed a clear separation between cutaneous lupus erythematosus skin and blood samples...
October 2017: Journal of Investigative Dermatology. Symposium Proceedings
https://www.readbyqxmd.com/read/28941498/not-just-skin-deep-systemic-disease-involvement-in-patients-with-cutaneous%C3%A2-lupus
#13
REVIEW
Jack C O'Brien, Benjamin F Chong
Cutaneous lupus erythematosus, specifically discoid lupus erythematosus, disproportionately affects those with skin of color and may result in greater dyspigmentation and scarring in darker skin types. In this article, we review investigations relevant to cutaneous lupus patients with skin of color at University of Texas Southwestern Medical Center, associations and risk of progression to systemic lupus, and recommendations for monitoring for systemic disease spread. Between 5% and 25% of patients with cutaneous lupus can develop systemic lupus...
October 2017: Journal of Investigative Dermatology. Symposium Proceedings
https://www.readbyqxmd.com/read/28941497/cutaneous-lupus-a-brief-review-of-old-and-new-medical-therapeutic-options
#14
REVIEW
Fnu Nutan, Alex G Ortega-Loayza
Systemic lupus erythematosus is a chronic inflammatory condition which affects predominantly women in their 30s. It has several clinical manifestations, including skin lesions that can be classified as acute cutaneous lupus erythematosus, subacute cutaneous lupus erythematosus, and chronic cutaneous lupus erythematosus. A multifaceted approach to treating cutaneous lupus is advocated.
October 2017: Journal of Investigative Dermatology. Symposium Proceedings
https://www.readbyqxmd.com/read/28941496/quinacrine-suppresses-tumor-necrosis-factor-%C3%AE-and-ifn-%C3%AE-in-dermatomyositis-and%C3%A2-cutaneous-lupus-erythematosus
#15
REVIEW
Paul Alves, Muhammad M Bashir, Maria Wysocka, Majid Zeidi, Rui Feng, Victoria P Werth
Antimalarials are used to treat dermatomyositis (DM) and cutaneous lupus erythematosus (CLE). Although hydroxychloroquine (HCQ) is frequently used, addition of quinacrine (QC) has shown additional clinical effects when combined with HCQ. To quantify the effects of HCQ versus QC in suppressing secretion of tumor necrosis factor-α (TNF-α) and IFN-α from the peripheral blood mononuclear cells of DM and CLE patients, lipopolysaccharide-stimulated and control peripheral blood mononuclear cells from DM and CLE patients and control subjects were analyzed for the effect of HCQ and QC on TNF-α and IFN-α production using ELISA testing...
October 2017: Journal of Investigative Dermatology. Symposium Proceedings
https://www.readbyqxmd.com/read/28941489/from-bench-to-bedside-the-hampton-university-skin-of-color-research-institute-2015-skin-of-color-symposium
#16
EDITORIAL
Clinton W Enos, Valerie M Harvey
The Hampton University Skin of Color Research Institute Skin of Color Symposium 2015: From Bench to Bedside was held in Williamsburg, Virginia at the Williamsburg Lodge, November 13-15, 2015. The conference was designed to promote, develop, and advance the education, knowledge, and research of cutaneous disorders disproportionately affecting people of racial and ethnic minority groups. Centered on the theme of "From Bench to Bedside", the symposium provided a program featuring a diverse panel of nationally recognized physician-scientists, basic scientists, and clinicians who updated attendees on the latest research advances across multiple relevant disciplines, including public health, basic science, and the clinical diagnosis and management of select complex and rare dermatologic conditions...
October 2017: Journal of Investigative Dermatology. Symposium Proceedings
https://www.readbyqxmd.com/read/28940367/subacute-cutaneous-lupus-erythematosus-induced-by-masitinib
#17
Daniel Nieto-Rodríguez, Cristina Gómez-Fernández, José Manuel Rueda-Carnero, Pedro Herranz-Pinto
No abstract text is available yet for this article.
November 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/28938508/-angina-pectoris-in-a-young-woman-with-lupus-erythematosus
#18
Simon Braumann, Malte P Bartram, Roman Pfister, Guido Michels
History and clinical findings We present a 31-year old woman with a 6-year history of cutaneous lupus erythematosus (CLE) who presented to the emergency room with typical chest pain. ECG and transthoracic echocardiography were normal. Her working diagnosis of pericarditis was made due to systemic progression of her lupus erythematosus (LE). Treatment with NSAIDs was initiated and her immunosuppressive regimen intensified. The patient was discharged after resolution of her symptoms. A week later, the patient was seen at the rheumatology clinic with recurrence and aggravation of her symptoms...
September 2017: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/28937502/type-iii-interferons-in-systemic-lupus-erythematosus-association-between-interferon-%C3%AE-3-disease-activity-and-anti-ro-ssa-antibodies
#19
Luis M Amezcua-Guerra, Ricardo Márquez-Velasco, Adriana K Chávez-Rueda, Diana Castillo-Martínez, Felipe Massó, Araceli Páez, Juan Colín-Fuentes, Rafael Bojalil
OBJECTIVE: The aim of this study was to assess associations between serum type III (λ) interferons (IFN-λ) and disease activity in systemic lupus erythematosus (SLE). METHODS: Serum levels of IFN-λ1, IFN-λ2, and IFN-λ3 were measured in 93 SLE patients and 67 healthy individuals. The associations with overall disease activity, organ-specific damage, and SLE-related antibodies were assessed. RESULTS: Median IFN-λ1 levels were 0 pg/mL (range, 0-510 pg/mL) and 0 pg/mL (0-171 pg/mL; P = 0...
September 21, 2017: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/28937472/type-iii-interferons-in-systemic-lupus-erythematosus-association-between-interferon-%C3%AE-3-disease-activity-and-anti-ro-ssa-antibodies
#20
Luis M Amezcua-Guerra, Ricardo Márquez-Velasco, Adriana K Chávez-Rueda, Diana Castillo-Martínez, Felipe Massó, Araceli Páez, Juan Colín-Fuentes, Rafael Bojalil
OBJECTIVE: The aim of this study was to assess associations between serum type III (λ) interferons (IFN-λ) and disease activity in systemic lupus erythematosus (SLE). METHODS: Serum levels of IFN-λ1, IFN-λ2, and IFN-λ3 were measured in 93 SLE patients and 67 healthy individuals. The associations with overall disease activity, organ-specific damage, and SLE-related antibodies were assessed. RESULTS: Median IFN-λ1 levels were 0 pg/mL (range, 0-510 pg/mL) and 0 pg/mL (0-171 pg/mL; P = 0...
October 2017: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
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