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Cutaneous lupus

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https://www.readbyqxmd.com/read/29686954/cutaneous-neonatal-lupus-erythematosus-a-case-report
#1
Kamleshun Ramphul, Stephanie G Mejias, Yogeshwaree Ramphul-Sicharam
Cutaneous neonatal lupus erythematosus (NLE) is a rare condition caused by the passive transfer of autoantibodies from mother to fetus. The disease most commonly presents itself with multiple erythematosus annular lesions or arcuate macules. In 10% of the cases, a cardiac anomaly can coexist. Appropriate diagnosis and laboratory and cardiac testing should be done to rule out any complications. Treatment usually includes topical steroids, following which the lesions will disappear after about eight weeks with no sequelae...
February 21, 2018: Curēus
https://www.readbyqxmd.com/read/29676592/pulsed-dye-laser-as-an-adjuvant-treatment-for-discoid-lupus-erythematosus-a-randomized-controlled-trial
#2
Pawinee Rerknimitr, Nucharin Tekacharin, Ratchathorn Panchaprateep, Jade Wititsuwannakul, Pattarin Tangtanatakul, Nattiya Hirankarn, Pravit Asawanonda
PURPOSE: To evaluate the efficacy and safety of PDL for DLE in a double blinded, randomized, controlled fashion. METHOD: Forty-eight DLE lesions from nine patients were recruited. The lesions on one side of the body were randomized into the treatment group and the other side served as a control. Treatments with the PDL (595nm) were delivered every 4 weeks for 4 consecutive months. The patients were evaluated at weeks 0, 4, 8, 12, 16 and 24. Erythema index (EI) and Texture index (TI) were obtained by Antera3D®...
April 20, 2018: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/29672364/role-of-direct-immunofluorescence-in-cutaneous-small-vessel-vasculitis-experience-from-a-tertiary-center
#3
Khushboo Lath, Debajyoti Chatterjee, Uma Nahar Saikia, Biman Saikia, Ranjana Minz, Dipankar De, Sanjeev Handa, Bishan Radotra
Skin is commonly affected by vasculitic process and often subjected to biopsy. Cutaneous vasculitis can be either primary or part of a systemic vasculitic process. This study was conducted to evaluate the diagnostic utility of direct immunofluorescence (DIF) in determination of etiology of cutaneous vasculitis. All histologically proven cases of cutaneous vasculitis over the past two and half years were retrospectively analyzed along with their clinical and DIF findings (IgG, IgA, IgM, and C3). Within this study period, a total of 198 cases of small-vessel vasculitis were diagnosed based on skin biopsy and DIF findings...
April 17, 2018: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/29669547/cutaneous-lupus-erythematosus-in-dogs-a-comprehensive-review
#4
REVIEW
Thierry Olivry, Keith E Linder, Frane Banovic
Since the first description of discoid lupus erythematosus (LE) in two dogs in 1979, the spectrum of canine cutaneous lupus erythematosus (CLE) variants has expanded markedly.In this review, we first propose an adaptation of the Gilliam-Sontheimer classification of CLE for dogs. We then review the signalment, clinical signs, laboratory and histopathology and treatment outcome of the currently recognized variants of canine CLE, which are vesicular CLE, exfoliative CLE, mucocutaneous LE and facial or generalized discoid LE...
April 18, 2018: BMC Veterinary Research
https://www.readbyqxmd.com/read/29669194/racial-disparities-in-the-incidence-of-primary-chronic-cutaneous-lupus-erythematosus-in-the-southeastern-united-states-the-georgia-lupus-registry
#5
Cristina Drenkard, Sareeta Parker, Laura D Aspey, Caroline Gordon, Charles G Helmick, Gaobin Bao, S Sam Lim
OBJECTIVE: Relative to SLE, epidemiologic studies on chronic cutaneous lupus erythematosus (CCLE) are rare and limited to populations without racial diversity. We sought to provide minimum estimates of the incidence of primary CCLE (CCLE in absence of SLE) in a predominantly white and black population in the Southestern United States. METHODS: The Georgia Lupus Registry used multiple sources for case finding, including dermatology and rheumatology practices, multispecialty healthcare facilities, and dermatopathology reports...
April 18, 2018: Arthritis Care & Research
https://www.readbyqxmd.com/read/29668590/a-case-report-of-lupus-erythematosus-tumidus-converted-from-discoid-lupus-erythematosus
#6
Xiaomei Chen, Sheng Wang, Li Li
RATIONALE: Lupus erythematosus tumidus (LET) is an uncommon type of cutaneous lupus erythematosus (CLE) that is rarely associated with other forms of lupus erythematosus. PATIENT CONCERNS: We report a 62-year-old Chinese man presented with recurrent erythematous facial plaques for 1 year and a low-grade fever for 1 week. He had been diagnosed as discoid lupus erythematosus (DLE) 1 year before. Physical examination showed diverse lesions, including prominent swelling of the eyelids, a few erythematous, edematous plaques on the left forehead, face, and neck, and 2 hairless macules...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29665756/photoprotection-awareness-and-practices-among-patients-with-systemic-lupus-erythematosus-and-its-association-with-disease-activity-and-severity
#7
W D Abdul Kadir, A Jamil, S Sazliyana Shaharir, N Md Nor, A H Abdul Gafor
Objective The objective of this paper is to determine photoprotection awareness, knowledge, practices, and its relationship with disease activity and damage in patients with systemic lupus erythematosus (SLE). Methods A cross-sectional study was performed. Data were acquired from in-person interviews and medical records. Results A total of 199 (89.6%) females and 23 (10.4%) males were recruited. Median age was 39.00 (interquartile range (IQR) 18) years, disease duration 12.12 (IQR 8) years, Fitzpatrick skin phototype III 119 (53...
January 1, 2018: Lupus
https://www.readbyqxmd.com/read/29643425/a-novel-two-score-system-for-interferon-status-segregates-autoimmune-diseases-and-correlates-with-clinical-features
#8
Y M El-Sherbiny, A Psarras, M Y Md Yusof, E M A Hensor, R Tooze, G Doody, A A A Mohamed, D McGonagle, M Wittmann, P Emery, E M Vital
Measurement of type I interferon (IFN-I) has potential to diagnose and stratify autoimmune diseases, but existing results have been inconsistent. Interferon-stimulated-gene (ISG) based methods may be affected by the modularity of the ISG transcriptome, cell-specific expression, response to IFN-subtypes and bimodality of expression. We developed and clinically validated a 2-score system (IFN-Score-A and -B) using Factor Analysis of 31 ISGs measured by TaqMan selected from 3-IFN-annotated modules. We evaluated these scores using in-vitro IFN stimulation as well as in sorted cells then clinically validated in a cohort of 328 autoimmune disease patients and healthy controls...
April 11, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29625815/cutaneous-lupus-erythematosus-morphea-profunda-and-psoriasis-a-case-report
#9
Mónica García-Arpa, Miguel A Flores-Terry, Claudia Ramos-Rodríguez, Monserrat Franco-Muñoz, Lucía González-Ruiz, Marco Aurelio Ramírez-Huaranga
Psoriasis is a common inflammatory dermatosis that may be associated with a number of diseases. Recent studies provide evidence that there is a greater frequency of autoimmune diseases, but association with autoimmune connective tissue diseases is uncommon. The coexistence of psoriasis and lupus erythematosus is rare. Besides, the occurrence of morphea has rarely been reported in patients with lupus or psoriasis. We report a woman with cutaneous lupus and morphea profunda associated with psoriasis, with an excellent response to methotrexate, and review the literature...
April 3, 2018: Reumatología Clinica
https://www.readbyqxmd.com/read/29570834/successful-treatment-of-severe-subacute-cutaneous-lupus-erythematosus-with-rituximab-in-an-adolescent
#10
Melissa Dodds, Patricia Hobday, Brittney Schultz, Sheilagh Maguiness
Subacute cutaneous lupus erythematosus is rare in children. Most patients respond well to conventional therapy with prednisone, hydroxychloroquine, or both. Other case reports and small series have reported successful clearance with rituximab in adults. We report an adolescent who obtained remission with rituximab after failing conventional therapy.
March 23, 2018: Pediatric Dermatology
https://www.readbyqxmd.com/read/29552450/a-case-of-htlv-1-associated-adult-t-cell-lymphoma-presenting-with-cutaneous-lesions-and-tropical-spastic-paresis
#11
Purva V Sharma, Michael Witteman, Swethika Sundaravel, Tulisa Larocca, Yuanming Zhang, Harry Goldsztajn
Adult T cell lymphoma (ATL), is a peripheral T cell neoplasm associated with infection by human T-lymphotropic virus (HTLV). This is a case of a 28-year-old lady who presented with back pain for the past month and recent onset weakness in her lower extremities bilaterally. She has a history of T-cell lymphoma secondary to HTLV-1 under remission since 2014 and systemic lupus erythematosus complicated by lupus nephritis. On physical examination patient had hyper-reflexia in both knees, ankle clonus bilaterally and spasticity in both her lower extremities...
February 2018: Intractable & Rare Diseases Research
https://www.readbyqxmd.com/read/29537450/intramuscular-steroids-in-the-treatment-of-dermatologic-disease-a-systematic-review
#12
Logan W Thomas, Ashley Elsensohn, Terese Bergheim, Jessica Shiu, Anand Ganesan
IMPORTANCE: Intramuscular (IM) steroids can be used to treat a wide variety of dermatologic diseases. Although seemingly effective and safe, this form of corticosteroid therapy may be underused amongst dermatologists. OBJECTIVE: The objective of this review is to determine the evidence regarding the efficacy and side effect profile of intramuscular triamcinolone in the treatment of dermatologic disease. EVIDENCE REVIEW: A PubMed search engine was used for this study...
March 1, 2018: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/29536981/bilateral-turkey-ear-as-a-cutaneous-manifestation-of-lupus-vulgaris
#13
Yingjie Lu, Hongmiao Wang, Hua Zheng, Xiao Li
Lupus vulgaris is a common form of cutaneous tuberculosis in China, mostly involving the head and neck region. Turkey ear is a clinically descriptive term, used for a massively enlarged earlobe with bluish-red or violaceous indurated plaques and nodules, which can be a sign of lupus vulgaris. A 47-year-old female presented with edema and reddish ulcerated lesions on both ears which was diagnosed as lupus vulgaris by conventional laboratory investigations and the patient showed good response to antituberculous therapy...
March 14, 2018: Indian Journal of Dermatology, Venereology and Leprology
https://www.readbyqxmd.com/read/29531772/remission-and-low-disease-activity-in-systemic-lupus-erythematosus-an-achievable-goal-even-with-fewer-steroids-real-life-data-from-a-monocentric-cohort
#14
Chiara Tani, Roberta Vagelli, Chiara Stagnaro, Linda Carli, Marta Mosca
Objectives: To evaluate what proportion of patients fulfil the DORIS definition of remission, the definition of lupus low disease activity state (LLDAS) and LLDAS with a glucocorticoid (GC) dosage ≤5 (LLDAS5) in a longitudinal monocentric cohort of patients with SLE; to identify predictors of sustained remission and LLDAS attainment; to evaluate the effect of sustained remission and LLDAS on damage accrual over a period of 5 years and compare the two conditions in terms of clinical outcomes...
2018: Lupus Science & Medicine
https://www.readbyqxmd.com/read/29524279/epidermal-necrolysis-and-autoimmune-diseases-two-more-observations-supporting-the-concept-that-toxic-epidermal-necrolysis-can-be-non-toxic
#15
LETTER
M Dumas, C Hua, C Hotz, C Velter, T A Duong, T Maraffi, N Ortonne, S Hüe, L Fardet, N de Prost, P Wolkenstein, S Ingen-Housz-Oro, O Chosidow
No abstract text is available yet for this article.
March 10, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29524269/dermatomyositis-panniculitis-a-clinico-pathologic-and-immunohistochemical-study-of-18-cases
#16
Angel Santos Briz, Anaid Calle, Konstantinos Linos, Bruce Semans, Andrew Carlson, Omar P Sangüeza, Dieter Metze, Lorenzo Cerroni, José Luis Díaz-Recuero, Victoria Alegría-Landa, José Manuel Mascaró, Carmen Moreno, Jose Luis Rodríguez-Peralto, Luis Requena
BACKGROUND: Panniculitis occurring in dermatomyositis is uncommon, with only a few cases described in the literature, most of them as case reports. OBJECTIVE: This report describes the clinico-pathological and immunohistochemical findings in a series of 18 patients with panniculitis associated to dermatomyositis. METHODS: In each patient we collected the clinical data of the cutaneous lesions as well as the characteristic clinical and laboratory findings...
March 10, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29517495/hydroxychloroquine-balancing-the-need-to-maintain-therapeutic-levels-with-ocular-safety-an-update
#17
Nada Abdulaziz, Anjali R Shah, William J McCune
PURPOSE OF REVIEW: Antimalarial drugs including chloroquine, its less toxic quinolone-derivative hydroxychloroquine (HCQ), and quinacrine have become cornerstones in the treatment of autoimmune diseases including systemic lupus, rheumatoid arthritis, sarcoidosis, and Sjogren syndrome; cutaneous disorders, antiphospholipid syndrome, and have recently been employed at higher dioses in oncology. Benefits include anti-inflammatory effects, protection against thrombosis, and improved control of hyperglycemia and hyperlipidemia...
May 2018: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/29514557/incremental-health-care-services-and-expenditures-associated-with-depression-among-individuals-with-cutaneous-lupus-erythematosus-cle
#18
M E Ogunsanya, S O Nduaguba, C M Brown
Objectives The objective of this paper is to describe the annual direct medical expenditures for cutaneous lupus erythematosus (CLE) patients, and to estimate the incremental health care expenditures and utilization associated with depression among adults with CLE, while controlling for covariates. Methods Using the 2014 Medical Expenditure Panel Survey (MEPS), we compared CLE patients with and without depression to determine differences in: (a) health care utilization-inpatient, outpatient, office-based and emergency room (ER) visits, and prescriptions filled; and (b) expenditures-total costs, inpatient, outpatient, office-based, ER, and prescription medication costs, and other costs using demography-adjusted and comorbidity-adjusted multivariate models (age, gender, race/ethnicity, marital status, education, perception of health status, poverty category, smoking status, and Charlson Comorbidity Index)...
January 1, 2018: Lupus
https://www.readbyqxmd.com/read/29503567/the-investigation-for-potential-modifier-genes-in-patients-with-neurofibromatosis-type-1-based-on-next-generation-sequencing
#19
Fan Yang, Song Xu, Renwang Liu, Tao Shi, Xiongfei Li, Xuebing Li, Gang Chen, Hongyu Liu, Qinghua Zhou, Jun Chen
Introduction: Neurofibromatosis type 1 (NF1) is a common Mendelian multi-system disorder that is characterized by café-au-lait spots (CLS), axillary freckling, optic glioma and plexiform neurofibroma. Various mutations of the NF1 gene are widely accepted to be the main cause of this disease, while whether there are still certain other modifier genes that could influence the phenotypes of NF1 is our concern. Patients and Methods: One proband and his father are involved, who are characterized by plexiform neurofibroma and cutaneous neurofibroma, respectively...
2018: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29496481/risk-of-thromboembolic-events-in-patients-treated-with-thalidomide-for-cutaneous-lupus-erythematosus-a-multicenter-retrospective-study
#20
Elise Cesbron, Didier Bessis, Marie Jachiet, Dan Lipsker, Nadège Cordel, Jean-David Bouaziz, Martine Bagot, Laurent Arnaud, Annick Barbaud, Camille Francès, François Chasset
No abstract text is available yet for this article.
February 26, 2018: Journal of the American Academy of Dermatology
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