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https://www.readbyqxmd.com/read/28220312/preventing-hiv-and-hepatitis-infections-among-people-who-inject-drugs-leveraging-an-indiana-outbreak-response-to-break-the-impasse
#1
EDITORIAL
Jeffrey S Crowley, Gregorio A Millett
Providing clean needles through syringe services programs (SSPs) prevents the spread of disease among people who inject drugs (PWID). The recent HIV outbreak in Scott County, Indiana was a wakeup call with particular significance because modeling suggests that Scott County is but one of many counties in the United States highly vulnerable to an HIV outbreak among PWID. It is a painful recognition that some policy makers ignored the evidence in support of SSPs when it was primarily blacks in inner cities that were affected, yet swung into action in the wake of Scott County where 99% of the cases were white...
February 20, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/28214391/correlates-of-willingness-to-initiate-pre-exposure-prophylaxis-and-anticipation-of-practicing-safer-drug-and-sex-related-behaviors-among-high-risk-drug-users-on-methadone-treatment
#2
Roman Shrestha, Pramila Karki, Frederick L Altice, Tania B Huedo-Medina, Jaimie P Meyer, Lynn Madden, Michael Copenhaver
BACKGROUND: Although people who use drugs (PWUD) are key populations recommended to receive pre-exposure prophylaxis (PrEP) to prevent HIV, few data are available to guide PrEP delivery in this underserved group. We therefore examined the willingness to initiate PrEP and the anticipation of HIV risk reduction while on PrEP among high-risk PWUD. METHODS: In a cross-sectional study of 400 HIV-negative, opioid dependent persons enrolled in a methadone program and reporting recent risk behaviors, we examined independent correlates of being willing to initiate PrEP...
February 2, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28212298/prevalence-and-clinical-impact-of-human-pegivirus-1-infection-in-hiv-1-infected-individuals-in-yunnan-china
#3
Zhijiang Miao, Li Gao, Yindi Song, Ming Yang, Mi Zhang, Jincheng Lou, Yue Zhao, Xicheng Wang, Yue Feng, Xingqi Dong, Xueshan Xia
Human Pegivirus-1 (HPgV-1) may have a beneficial impact on disease progression in human immunodeficiency virus-1 (HIV-1) infection. However, analysis of the genotypic diversity of HPgV-1 and its relevance to the progression of HIV-1 disease remains limited. A total of 1062 HIV-1-infected individuals were recruited in all sixteen prefectures of Yunnan province, China. The reverse transcription nested polymerase chain reaction (RT-nPCR), phylogenetic analyses, and clinical data analyses were used to detect HPgV-1 infection, determine genotype, and analyze HPgV-1 genotype impact on HIV-1 disease progression...
February 15, 2017: Viruses
https://www.readbyqxmd.com/read/28196995/injection-drug-use-among-children-and-adolescents-in-india-ringing-the-alarm-bells
#4
Anju Dhawan, Raman Deep Pattanayak, Anita Chopra, Vinod Kumar Tikoo, Rajesh Kumar
INTRODUCTION: Injection drug use (IDU) is intricately linked to preventive aspects for human immunodeficiency virus from a public health perspective. No large-scale data are yet available for injectable drug use among children and adolescents in India, apart from few anecdotal reports. AIMS AND METHODS: The present paper reports on the profile and substance use pattern of 509 child IDU users, among a total sample of over 4000 children using substances across 100 sites from 27 states and 2 UTs in India...
October 2016: Indian Journal of Psychiatry
https://www.readbyqxmd.com/read/28194580/hepatitis-c-virus-genotype-3a-in-a-population-of-injecting-drug-users-in-montenegro-bayesian-and-evolutionary-analysis
#5
Boban Mugosa, Eleonora Cella, Alessia Lai, Alessandra Lo Presti, Aletheia Blasi, Zoran Vratnica, Danijela Vujoševic, Erika Ebranati, Dragan Lauševic, Michele Guarino, Gianguglielmo Zehender, Teresa Milano, Stefano Pascarella, Silvia Spoto, Silvia Angeletti, Massimo Ciccozzi
Few reports are available on HCV molecular epidemiology among IDUs in Eastern Europe, and none in Montenegro. The aim of this study was to investigate the HCV genotype distribution in Montenegro among IDUs and to perform Bayesian and evolutionary analysis of the most prevalent HCV genotype circulating in this population. Sixty-four HCV-positive IDUs in Montenegro were enrolled between 2013 and 2014, and the NS5B gene was sequenced. The Bayesian analysis showed that the most prevalent subtype was HCV-3a. Phylogenetic data showed that HCV-3a reached Montenegro in the late 1990s, causing an epidemic that exponentially grew between the 1995 and 2005...
February 13, 2017: Archives of Virology
https://www.readbyqxmd.com/read/28193236/coverage-of-harm-reduction-services-and-hiv-infection-a-multilevel-analysis-of-five-chinese-cities
#6
Qing Wu, Carlijn Kamphuis, Lin Duo, Jiahong Luo, Ying Chen, Jan Hendrik Richardus
BACKGROUND: Since 2003, a harm reduction program for injecting drug users has been rolled out countrywide in China. It entails services for condom promotion, a needle and syringe program (NSP), and methadone maintenance treatment (MMT). However, it remains unknown if and to what extent the coverage of these services at city level is related to a reduced risk of HIV infection among drug users. METHODS: We wished to quantify the extent to which city-level characteristics (such as NSP and MMT service coverage) and individual-level determinants (e...
February 14, 2017: Harm Reduction Journal
https://www.readbyqxmd.com/read/28167133/nmda-receptor-adjusted-co-administration-of-ecstasy-and-cannabinoid-receptor-1-agonist-in-the-amygdala-via-stimulation-of-bdnf-trk-b-creb-pathway-in-adult-male-rats
#7
Ghorbangol Ashabi, Mitra-Sadat Sadat-Shirazi, Solmaz Khalifeh, Laleh Elhampour, Mohammad-Reza Zarrindast
Consumption of cannabinoid receptor-1 (CB-1) agonist such as cannabis is widely taken in 3,4- methylenedioxymethamphetamine (MDMA) or ecstasy users; it has been hypothesized that co-consumption of CB-1 agonist might protect neurons against MDMA toxicity. N-methyl-D-aspartate (NMDA) receptors regulate neuronal plasticity and firing rate in the brain through Tyrosine-kinase B (Trk-B) activation. The molecular and electrophysiological association among NMDA and MDMA/Arachidonylcyclopropylamide (ACPA, a selective CB-1 receptor agonist) co-consumption was not well-known...
February 3, 2017: Brain Research Bulletin
https://www.readbyqxmd.com/read/28158995/declining-rates-of-health-problems-associated-with-crack-smoking-during-the-expansion-of-crack-pipe-distribution-in-vancouver-canada
#8
Amy Prangnell, Huiru Dong, Patricia Daly, M J Milloy, Thomas Kerr, Kanna Hayashi
BACKGROUND: Crack cocaine smoking is associated with an array of negative health consequences, including cuts and burns from unsafe pipes, and infectious diseases such as HIV. Despite the well-established and researched harm reduction programs for injection drug users, little is known regarding the potential for harm reduction programs targeting crack smoking to reduce health problems from crack smoking. In the wake of recent crack pipe distribution services expansion, we utilized data from long running cohort studies to estimate the impact of crack pipe distribution services on the rates of health problems associated with crack smoking in Vancouver, Canada...
February 3, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28157414/comparing-characteristics-of-early-onset-injection-drug-users-to-those-with-late-onset-injection-in-kermanshah-iran
#9
Zahra Jojaran Shushtari, Alireza Noroozi, Ali Mirzazadeh, Elahe Ahounbar, Ahmad Hajbi, Mohammad Najafi, Ali Bazrafshan, Mohammad Hossin Farhadi, Ali Farhoudian, Peter Higgs, Farahnaz Mohammadi Shahboulagh, Katherine Waye, Mehdi Noroozi
BACKGROUND: Characteristics and behaviors of early-onset injection drug users are under studied topics in Iran. This study aimed to identify and compare the demographic characteristics as well as the drug using behaviors of early-onset and late-onset injection drug users in Kermanshah, West Iran. METHODS: In this cross-sectional study using snowball and convenience sampling, we recruited 450 people during the Fall of 2014 from two drop in centers in Kermanshah, Iran...
February 3, 2017: Substance Use & Misuse
https://www.readbyqxmd.com/read/28157413/exploring-the-new-phenomena-of-home-made-extraction-and-injection-of-ephedra-plant-product-in-georgia
#10
David Otiashvili, Irma Kirtadze, Dessa Bergen-Cico
BACKGROUND: Since the end of 2015, reports by service providers have indicated a new trend in kitchen (homemade) production of an injection drug prepared from an ephedrine-containing conifer bush that is indigenous to the region. OBJECTIVE: The aim of this report is to describe an emerging new homemade psychoactive drug synthesized from the ephedra plant, and the drug consumption methods associated with its' use in the Eurasia. METHODS: Focus groups conducted with 16 people, self-identified as injection drug users (IDU's) who reported at least one incidence of ephedra preparation injection during the previous 30-days...
February 3, 2017: Substance Use & Misuse
https://www.readbyqxmd.com/read/28152026/hiv-prevalence-and-gender-differences-among-new-injection-drug-users-in-tallinn-estonia-a-persisting-problem-in-a-stable-high-prevalence-epidemic
#11
Anneli Uusküla, Mait Raag, Kristina Marsh, Ave Talu, Sigrid Vorobjov, Don Des Jarlais
INTRODUCTION: New injectors / younger drug users are an important population to target for intervention because they are often at especially high risk of HIV and HCV infection. We examined HIV prevalence and gender differences in HIV prevalence and risk behavior among new injection-drug-users in Tallinn, Estonia. METHODS: Respondent driven sampling (RDS) interview surveys and HIV testing were conducted in Tallinn in 2009, 2011 and 2013. We classified "new injectors" as persons who reported their first injection as occurring within three years of the study interview...
2017: PloS One
https://www.readbyqxmd.com/read/28132704/reducing-non-injection-drug-use-in-hiv-primary-care-a-randomized-trial-of-brief-motivational-interviewing-with-and-without-healthcall-a-technology-based-enhancement
#12
Efrat Aharonovich, Aaron Sarvet, Malki Stohl, Don DesJarlais, Susan Tross, Teresa Hurst, Antonio Urbina, Deborah Hasin
AIMS: In HIV-infected individuals, non-injection drug use (NIDU) compromises many health outcomes. In HIV primary care, the efficacy of brief motivational interviewing (MI) to reduce NIDU is unknown, and drug users may need greater intervention. We designed an enhancement to MI, HealthCall (HC), for daily patient self-monitoring calls to an interactive voice response (IVR) phone system, and provided participants with periodic personalized feedback. To reduce NIDU among HIV primary care patients, we compared the efficacy of MI+HealthCall to MI-only and an educational control condition...
March 2017: Journal of Substance Abuse Treatment
https://www.readbyqxmd.com/read/28130629/pence-putin-mbeki-and-their-hiv-aids-related-crimes-against-humanity-call-for-social-justice-and-behavioral-science-advocacy
#13
EDITORIAL
Seth C Kalichman
Indiana, a large rural state in the Midwestern United States, suffered the worst North American HIV outbreak among injection drug users in years. The Indiana state government under former Governor and current US Vice President Mike Pence fueled the HIV outbreak by prohibiting needle/syringe exchange and failed to take substantive action once the outbreak was identified. This failure in public health policy parallels the HIV epidemics driven by oppressive drug laws in current day Russia and is reminiscent of the anti-science AIDS denialism of 1999-2007 South Africa...
January 27, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/28130026/national-sex-work-policy-and-hiv-prevalence-among-sex-workers-an-ecological-regression-analysis-of-27-european-countries
#14
Aaron Reeves, Sarah Steele, David Stuckler, Martin McKee, Andrew Amato-Gauci, Jan C Semenza
BACKGROUND: Sex workers are disproportionately affected by HIV compared with the general population. Most studies of HIV risk among sex workers have focused on individual-level risk factors, with few studies assessing potential structural determinants of HIV risk. In this Article, we examine whether criminal laws around sex work are associated with HIV prevalence among female sex workers. METHOD: We estimate cross-sectional, ecological regression models with data from 27 European countries on HIV prevalence among sex workers from the European Centre for Disease Control; sex-work legislation from the US State Department's Country Reports on Human Rights Practices and country-specific legal documents; the rule of law and gross-domestic product per capita, adjusted for purchasing power, from the World Bank; and the prevalence of injecting drug use among sex workers...
January 24, 2017: Lancet HIV
https://www.readbyqxmd.com/read/28123210/the-2013-hiv-continuum-of-care-in-tennessee-progress-made-but-disparities-persist
#15
Carolyn Wester, Peter F Rebeiro, Thomas J Shavor, Bryan E Shepherd, Shanell L McGoy, Benn Daley, Melissa Morrison, Sten H Vermund, April C Pettit
OBJECTIVES: We measured patient engagement in the human immunodeficiency virus (HIV) continuum of care in Tennessee after implementation of enhanced surveillance activities to assess progress toward 2015 statewide goals. We also examined subgroup disparities to identify groups at risk for poor outcomes. METHODS: We estimated linkage to care, retention in care, and viral suppression among HIV-infected people in Tennessee in 2013, overall and by subgroup, after implementation of enhanced laboratory reporting, address verification, and death-matching procedures...
September 2016: Public Health Reports
https://www.readbyqxmd.com/read/28120592/profile-of-people-who-inject-drugs-in-tehran-iran
#16
Masoumeh Amin-Esmaeili, Afarin Rahimi-Movaghar, Maryam Gholamrezaei, Emran Mohammad Razaghi
The marked shift in the patterns of drug use in Iran, from opium smoking to injecting drug use, has led to serious health-related outcomes. This study was designed to explore characteristics of people who inject drugs (PWID) in Tehran, Iran. Nine hundred and four PWID were recruited from treatment and harm reduction facilities, as well as drug user hangouts in public areas in Tehran. Participants were interviewed using the Persian version of the World Health Organization Drug Injecting Study Phase II questionnaire...
December 2016: Acta Medica Iranica
https://www.readbyqxmd.com/read/28117545/recreational-drug-use-and-chemsex-among-hiv-infected-in-patients-a-unique-screening-opportunity
#17
E R Elliot, S Singh, S Tyebally, K Gedela, M Nelson
OBJECTIVES: While a high rate of recreational drug use (RDU) has been documented among HIV-infected out-patients, particularly in men who have sex with men (MSM), there is a distinct lack of data for HIV-infected in-patients. Hospital admission offers a unique opportunity to engage drug users. We aimed to establish and characterize RDU among new admissions to a large dedicated London HIV in-patient unit and compare it to RDU among general medical admissions to inform clinical pathways...
January 24, 2017: HIV Medicine
https://www.readbyqxmd.com/read/28111221/differential-experiences-of-mexican-policing-by-people-who-inject-drugs-residing-in-tijuana-and-san-diego
#18
Emily F Wood, Dan Werb, Leo Beletsky, Gudelia Rangel, Jazmine Cuevas Mota, Richard S Garfein, Steffanie A Strathdee, Karla D Wagner
BACKGROUND: Research among people who inject drugs (PWIDs) in the USA and Mexico has identified a range of adverse health impacts associated with policing of PWIDs. We employed a mixed methods design to investigate how PWIDs from San Diego and Mexico experienced policing in Tijuana, and how these interactions affect PWIDs behavior, stratifying by country of origin. METHODS: In 2012-2014, 575 PWIDs in San Diego, 102 of whom had used drugs in Mexico in the past six months, were enrolled in the STAHR-II study, with qualitative interviews conducted with a subsample of 20 who had recently injected drugs in Mexico...
January 19, 2017: International Journal on Drug Policy
https://www.readbyqxmd.com/read/28107670/pharmaceutical-opioid-use-among-oral-and-intravenous-users-in-australia-a-qualitative-comparative-study
#19
George Dertadian, Jenny Iversen, Thomas C Dixon, Katrina Sotiropoulos, Lisa Maher
BACKGROUND: Between 1992 and 2012 dispensing episodes for pharmaceutical opioids (PO) in Australia increased from 500000 to 7500000. In the US, increases in the prescription of PO have been linked to increases in opioid-related morbidity and mortality and transitions to heroin injection. However, Australian data indicate that morbidity and mortality related to PO are relatively low, particularly when compared to heroin and other drugs. This paper explores the characteristics and patterns of non-medical pharmaceutical opioid (NMPO) use among a sample of young people in Sydney, Australia...
January 17, 2017: International Journal on Drug Policy
https://www.readbyqxmd.com/read/28107423/characterization-of-the-drug-resistance-profiles-of-patients-infected-with-crf07_bc-using-phenotypic-assay-and-ultra-deep-pyrosequencing
#20
Szu-Wei Huang, Wei-You Li, Wen-Hung Wang, Yu-Ting Lin, Chih-Hung Chou, Marcelo Chen, Hsien-Da Huang, Yen-Hsu Chen, Po-Liang Lu, Sheng-Fan Wang, Shinichi Oka, Yi-Ming Arthur Chen
The usefulness of ultra-deep pyrosequencing (UDPS) for the diagnosis of HIV-1 drug resistance (DR) remains to be determined. Previously, we reported an explosive outbreak of HIV-1 circulating recombinant form (CRF) 07_BC among injection drug users (IDUs) in Taiwan in 2004. The goal of this study was to characterize the DR of CRF07_BC strains using different assays including UDPS. Seven CRF07_BC isolates including 4 from early epidemic (collected in 2004-2005) and 3 from late epidemic (collected in 2008) were obtained from treatment-naïve patient's peripheral blood mononuclear cells...
2017: PloS One
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