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psychedelic psychotherapy

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https://www.readbyqxmd.com/read/27435062/ayahuasca-enhances-creative-divergent-thinking-while-decreasing-conventional-convergent-thinking
#1
K P C Kuypers, J Riba, M de la Fuente Revenga, S Barker, E L Theunissen, J G Ramaekers
INTRODUCTION: Ayahuasca is a South American psychotropic plant tea traditionally used in Amazonian shamanism. The tea contains the psychedelic 5-HT2A receptor agonist N,N-dimethyltryptamine (DMT), plus β-carboline alkaloids with monoamine oxidase-inhibiting properties. Increasing evidence from anecdotal reports and open-label studies indicates that ayahuasca may have therapeutic effects in treatment of substance use disorders and depression. A recent study on the psychological effects of ayahuasca found that the tea reduces judgmental processing and inner reactivity, classic goals of mindfulness psychotherapy...
September 2016: Psychopharmacology
https://www.readbyqxmd.com/read/27392130/from-psychiatry-to-flower-power-and-back-again-the-amazing-story-of-lysergic-acid-diethylamide
#2
Hermann A M Mucke
Among the psychedelic drugs that enjoyed a period of popularity in psychiatric research during the 1950s and 1960s, lysergic acid diethylamide (LSD) is the most prominent one. Psychiatrists of that time had seen LSD not only as a tool for psychotherapy but also as a potential therapeutic for anxiety, depression, alcohol abuse, autism, and even schizophrenia. When it became a quasi-religious epitome of the Hippie counterculture in the mid 1960s, and cases of what we now call hallucinogen persisting perception disorder and acute psychotic "flashbacks" mounted, authorities moved to make LSD illegal...
July 8, 2016: Assay and Drug Development Technologies
https://www.readbyqxmd.com/read/27378878/ego-dissolution-and-psychedelics-validation-of-the-ego-dissolution-inventory-edi
#3
Matthew M Nour, Lisa Evans, David Nutt, Robin L Carhart-Harris
AIMS: The experience of a compromised sense of "self", termed ego-dissolution, is a key feature of the psychedelic experience. This study aimed to validate the Ego-Dissolution Inventory (EDI), a new 8-item self-report scale designed to measure ego-dissolution. Additionally, we aimed to investigate the specificity of the relationship between psychedelics and ego-dissolution. METHOD: Sixteen items relating to altered ego-consciousness were included in an internet questionnaire; eight relating to the experience of ego-dissolution (comprising the EDI), and eight relating to the antithetical experience of increased self-assuredness, termed ego-inflation...
2016: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/27354909/lysergic-acid-diethylamide-a-drug-of-use
#4
REVIEW
Saibal Das, Preeti Barnwal, Anand Ramasamy, Sumalya Sen, Somnath Mondal
Lysergic acid diethylamide (LSD), described as a classical hallucinogen, began its journey from the middle of the last century following an accidental discovery. Since then, it was used as a popular and notorious substance of abuse in various parts of the world. Its beneficial role as an adjunct to psychotherapy was much unknown, until some 'benevolent' experiments were carried out over time to explore some of its potential uses. But, many of its effects were unclear and seemed to be a psychedelic enigma. In this review article, we have described the receptor pharmacology, mechanism of action, effects and adverse effects of LSD on the normal body system...
June 2016: Therapeutic Advances in Psychopharmacology
https://www.readbyqxmd.com/read/27084302/lsd-modulates-music-induced-imagery-via-changes-in-parahippocampal-connectivity
#5
Mendel Kaelen, Leor Roseman, Joshua Kahan, Andre Santos-Ribeiro, Csaba Orban, Romy Lorenz, Frederick S Barrett, Mark Bolstridge, Tim Williams, Luke Williams, Matthew B Wall, Amanda Feilding, Suresh Muthukumaraswamy, David J Nutt, Robin Carhart-Harris
Psychedelic drugs such as lysergic acid diethylamide (LSD) were used extensively in psychiatry in the past and their therapeutic potential is beginning to be re-examined today. Psychedelic psychotherapy typically involves a patient lying with their eyes-closed during peak drug effects, while listening to music and being supervised by trained psychotherapists. In this context, music is considered to be a key element in the therapeutic model; working in synergy with the drug to evoke therapeutically meaningful thoughts, emotions and imagery...
July 2016: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/27067625/novel-psychopharmacological-therapies-for-psychiatric-disorders-psilocybin-and-mdma
#6
REVIEW
Michael C Mithoefer, Charles S Grob, Timothy D Brewerton
4-phosphorloxy-N,N-dimethyltryptamine (psilocybin) and methylenedioxymethamfetamine (MDMA), best known for their illegal use as psychedelic drugs, are showing promise as therapeutics in a resurgence of clinical research during the past 10 years. Psilocybin is being tested for alcoholism, smoking cessation, and in patients with advanced cancer with anxiety. MDMA is showing encouraging results as a treatment for refractory post-traumatic stress disorder, social anxiety in autistic adults, and anxiety associated with a life-threatening illness...
May 2016: Lancet Psychiatry
https://www.readbyqxmd.com/read/26841800/psychedelics
#7
REVIEW
David E Nichols
Psychedelics (serotonergic hallucinogens) are powerful psychoactive substances that alter perception and mood and affect numerous cognitive processes. They are generally considered physiologically safe and do not lead to dependence or addiction. Their origin predates written history, and they were employed by early cultures in many sociocultural and ritual contexts. After the virtually contemporaneous discovery of (5R,8R)-(+)-lysergic acid-N,N-diethylamide (LSD)-25 and the identification of serotonin in the brain, early research focused intensively on the possibility that LSD and other psychedelics had a serotonergic basis for their action...
April 2016: Pharmacological Reviews
https://www.readbyqxmd.com/read/26257162/lsd-enhances-the-emotional-response-to-music
#8
M Kaelen, F S Barrett, L Roseman, R Lorenz, N Family, M Bolstridge, H V Curran, A Feilding, D J Nutt, R L Carhart-Harris
RATIONALE: There is renewed interest in the therapeutic potential of psychedelic drugs such as lysergic acid diethylamide (LSD). LSD was used extensively in the 1950s and 1960s as an adjunct in psychotherapy, reportedly enhancing emotionality. Music is an effective tool to evoke and study emotion and is considered an important element in psychedelic-assisted psychotherapy; however, the hypothesis that psychedelics enhance the emotional response to music has yet to be investigated in a modern placebo-controlled study...
October 2015: Psychopharmacology
https://www.readbyqxmd.com/read/25818246/mdma-assisted-therapy-a-new-treatment-model-for-social-anxiety-in-autistic-adults
#9
RANDOMIZED CONTROLLED TRIAL
Alicia L Danforth, Christopher M Struble, Berra Yazar-Klosinski, Charles S Grob
The first study of 3,4-methylenedioxymethamphetamine (MDMA)-assisted therapy for the treatment of social anxiety in autistic adults commenced in the spring of 2014. The search for psychotherapeutic options for autistic individuals is imperative considering the lack of effective conventional treatments for mental health diagnoses that are common in this population. Serious Adverse Events (SAEs) involving the administration of MDMA in clinical trials have been rare and non-life threatening. To date, MDMA has been administered to over 1133 individuals for research purposes without the occurrence of unexpected drug-related SAEs that require expedited reporting per FDA regulations...
January 4, 2016: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/25670401/peak-experiences-and-the-afterglow-phenomenon-when-and-how-do-therapeutic-effects-of-hallucinogens-depend-on-psychedelic-experiences
#10
REVIEW
Tomislav Majić, Timo T Schmidt, Jürgen Gallinat
Interest in the therapeutic potential of psychedelic substances has recently resumed. During an early phase of human psychedelic research, their therapeutic application in different pathologies had been suggested, and the first evidence for efficacy was provided. The range of recent clinical applications of psychedelics spans from cluster headaches and obsessive-compulsive disorder to addiction and the treatment of fear and anxiety in patients suffering from terminal illness, indicating potentially different therapeutic mechanisms...
March 2015: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/25563447/crisis-intervention-related-to-the-use-of-psychoactive-substances-in-recreational-settings-evaluating-the-kosmicare-project-at-boom-festival
#11
Maria Carmo Carvalho, Mariana Pinto de Sousa, Paula Frango, Pedro Dias, Joana Carvalho, Marta Rodrigues, Tania Rodrigues
Kosmicare project implements crisis intervention in situations related to the use of psychoactive substances at Boom Festival (Portugal). We present evaluation research that aims to contribute to the transformation of the project into an evidence-based intervention model. It relies on harm reduction and risk minimization principles, crisis intervention models, and Grof's psychedelic psychotherapy approach for crisis intervention in situations related to unsupervised use of psychedelics. Intervention was expected to produce knowledge about the relation between substance use and mental health impact in reducing potential risk related to the use of psychoactive substances and mental illness, as well as an impact upon target population's views of themselves, their relationship to substance use, and to life events in general...
2014: Current Drug Abuse Reviews
https://www.readbyqxmd.com/read/24830183/history-and-future-of-the-multidisciplinary-association-for-psychedelic-studies-maps
#12
Amy Emerson, Linnae Ponté, Lisa Jerome, Rick Doblin
This article describes the teenage vision of the founder of the Multidisciplinary Association for Psychedelic Studies (MAPS) that humanity's future would be aided by the therapeutic and spiritual potential of psychedelic substances. The article traces the trajectory of MAPS from inception in 1986 to its present, noting future goals with respect to research, outreach, and harm reduction. MAPS was created as a non-profit psychedelic pharmaceutical company in response to the 1985 scheduling of 3,4-methylenedioxymethamphetamine (MDMA)...
January 2014: Journal of Psychoactive Drugs
https://www.readbyqxmd.com/read/24762477/the-metaphysical-combat-with-death-in-the-terminally-ill-and-the-psychedelic-trail
#13
EDITORIAL
Varsha Dutta
No abstract text is available yet for this article.
January 2014: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/24272672/mysticism-and-psychedelics-the-case-of-the-dark-night
#14
C M Bache
This study uses a model of consciousness derived from LSD-assisted psychotherapy to illumine an enigmatic set of painful experiences that occur on the mystic's path known in Western circles as the "dark night." It argues that the dark night experiences described in John of the Cross's classic workDark Night of the Soul can be conceptualized in terms of Stanislav Grofs category of "perinatal experience." The discussion examines the implications of this reconceptualization in three areas: (1) our understanding and evaluation of mysticism, (2) assessing LSD's potential for fostering genuine spirituality, and (3) reassessing the ancient claim that the capacity to experience transcendental states of being is innate...
September 1991: Journal of Religion and Health
https://www.readbyqxmd.com/read/23773089/the-potential-of-psychedelics-as-a-preventative-and-auxiliary-therapy-for-drug-abuse
#15
EDITORIAL
Hector Vargas-Perez, Rick Doblin
No abstract text is available yet for this article.
March 2013: Current Drug Abuse Reviews
https://www.readbyqxmd.com/read/23627786/can-mdma-play-a-role-in-the-treatment-of-substance-abuse
#16
REVIEW
Lisa Jerome, Shira Schuster, B Berra Yazar-Klosinski
A wider array of treatments are needed for people with substance abuse disorders. Some psychedelic compounds have been assessed as potential substance abuse treatments with promising results. MDMA may also help treat substance abuse based on shared features with psychedelic compounds and recent reports indicating that MDMAassisted psychotherapy can reduce symptoms of PTSD. Narrative reports and data from early investigations found that some people reduced or eliminated their substance use after receiving MDMA, especially in a therapeutic setting...
March 2013: Current Drug Abuse Reviews
https://www.readbyqxmd.com/read/23174711/repression-of-death-consciousness-and-the-psychedelic-trip
#17
REVIEW
Varsha Dutta
Death is our most repressed consciousness, it inheres our condition as the primordial fear. Perhaps it was necessary that this angst be repressed in man or he would be hurled against the dark forces of nature. Modern ethos was built on this edifice, where the 'denial of death' while 'embracing one's symbolic immortality' would be worshipped, so this ideology simply overturned and repressed looking into the morass of the inevitable when it finally announced itself. Once this slowly pieced its way into all of life, 'death' would soon become a terminology in medicine too and assert its position, by giving a push to those directly dealing with the dying to shy away from its emotional and spiritual affliction...
July 2012: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/22817963/shaping-the-renaissance-of-psychedelic-research
#18
Ben Sessa
No abstract text is available yet for this article.
July 21, 2012: Lancet
https://www.readbyqxmd.com/read/22282432/implications-for-psychedelic-assisted-psychotherapy-functional-magnetic-resonance-imaging-study-with-psilocybin
#19
RANDOMIZED CONTROLLED TRIAL
R L Carhart-Harris, R Leech, T M Williams, D Erritzoe, N Abbasi, T Bargiotas, P Hobden, D J Sharp, J Evans, A Feilding, R G Wise, D J Nutt
BACKGROUND: Psilocybin is a classic psychedelic drug that has a history of use in psychotherapy. One of the rationales for its use was that it aids emotional insight by lowering psychological defences. AIMS: To test the hypothesis that psilocybin facilitates access to personal memories and emotions by comparing subjective and neural responses to positive autobiographical memories under psilocybin and placebo. METHOD: Ten healthy participants received two functional magnetic resonance imaging scans (2 mg intravenous psilocybin v...
March 2012: British Journal of Psychiatry: the Journal of Mental Science
https://www.readbyqxmd.com/read/18459186/research-on-psychedelics-moves-into-the-mainstream
#20
Kelly Morris
No abstract text is available yet for this article.
May 3, 2008: Lancet
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