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https://www.readbyqxmd.com/read/28551920/-women-s-cardiac-health-from-theory-to-activism
#1
REVIEW
Avital Porter
Cardiovascular disease (CVD) is the leading cause of death in the western world, in both genders. Although awareness of the importance of prevention, diagnosis and optimal treatment of CVD has risen in general, most women are not fully aware of their CVD risk. Moreover, women are not alert to the burden of risk in their reproductive years (e.g. complicated pregnancy and/or peri-menopausal period) and their impact on future CVD. Unique Female issues such as: fertile age, menopause, oral contraceptives, hormonal and metabolic disorders during pregnancy, labor, as well as psychological matters, and healthy life-style are major contributors to primary and secondary prevention of CVD...
April 2017: Harefuah
https://www.readbyqxmd.com/read/28551902/-treatment-options-for-diabetic-macular-edema
#2
REVIEW
Efraim Berco, Daniel Rappoport, Ayala Pollack
Diabetic retinopathy (DR) is the leading cause of vision loss in people under 65 years of age. Diabetic macular edema (DME) is the most common cause of moderate visual impairment in individuals with DR. Until recently, focal or grid laser photocoagulation has been the standard of care for DME. Laser photocoagulation has been shown to stabilize vision and prevent moderate vision loss. Recent studies on the effect of anti-vascular endothelial growth factor (VEGF) substances in DME, showed resolution of the edema and visual acuity gain...
February 2017: Harefuah
https://www.readbyqxmd.com/read/28551895/-sentinel-lymph-nodes-dissection-in-gynecological-malignancies
#3
REVIEW
Yael Naaman, Limor Goldenhersh, Alon Ben-Arie
During the last decade sentinel lymph nodes biopsy has become an essential part of primary surgical treatment in a number of malignancies including breast cancer, melanoma and head-and-neck malignancies. Dye or radioactive substances are injected at the primary tumor site, followed by pre-operative and intra-operative mapping. During surgery only positive lymph nodes are being dissected instead of a complete dissection of the lymphatic basin. The advantages of sentinel lymph nodes dissection are reducing the side effects of extensive lymph nodes dissection, while maintaining high detection rates and sensitivity in identifying cases with lymphatic tumor spread...
February 2017: Harefuah
https://www.readbyqxmd.com/read/28551882/medical-geology-of-endemic-goiter-in-kalutara-sri-lanka-distribution-and-possible-causes
#4
G W A R Fernando, P L C L Liyanage, Anushka Upamali Rajapaksha, Meththika Vithanage
This study assesses the distribution of goiter in the Kalutara District, Sri Lanka in order to find causative factors for the occurrence of goiter even after the salt iodization. A questionnaire survey was conducted at the household level and at the same time iodine and selenium levels of the water sources were analyzed. Questionnaire survey results indicated the highest numbers of goiter patients in the northern part where the lowest were found in the southern sector which may be due to the presence of acid sulfate soils...
May 27, 2017: Environmental Geochemistry and Health
https://www.readbyqxmd.com/read/28551875/non-ureolytic-calcium-carbonate-precipitation-by-lysinibacillus-sp-ys11-isolated-from-the-rhizosphere-of-miscanthus-sacchariflorus
#5
Yun Suk Lee, Hyun Jung Kim, Woojun Park
Although microbially induced calcium carbonate precipitation (MICP) through ureolysis has been widely studied in environmental engineering fields, urea utilization might cause environmental problems as a result of ammonia and nitrate production. In this study, many non-ureolytic calcium carbonate-precipitating bacteria that induced an alkaline environment were isolated from the rhizosphere of Miscanthus sacchariflorus near an artificial stream and their ability to precipitate calcium carbonate minerals with the absence of urea was investigated...
June 2017: Journal of Microbiology / the Microbiological Society of Korea
https://www.readbyqxmd.com/read/28551715/direct-comparison-of-the-acute-subjective-emotional-autonomic-and-endocrine-effects-of-mdma-methylphenidate-and-modafinil-in-healthy-subjects
#6
Patrick C Dolder, Felix Müller, Yasmin Schmid, Stefan J Borgwardt, Matthias E Liechti
RATIONALE: 3,4-Methylenedioxymethamphetamine (MDMA) is used recreationally and investigated as an adjunct to psychotherapy. Methylphenidate and modafinil are psychostimulants that are used to treat attention-deficit/hyperactivity disorder and narcolepsy, respectively, but they are also misused as cognitive enhancers. Little is known about differences in the acute effects of equally cardiostimulant doses of these stimulant-type substances compared directly within the same subjects. METHODS: We investigated the acute autonomic, subjective, endocrine, and emotional effects of single doses of MDMA (125 mg), methylphenidate (60 mg), modafinil (600 mg), and placebo in a double-blind, cross-over study in 24 healthy participants...
May 27, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28551620/impact-of-small-molecules-on-%C3%AE-catenin-and-e-cadherin-expression-in-hpv16-positive-and-negative-squamous-cell-carcinomas
#7
Benedikt Kramer, Clemens Hock, Johannes David Schultz, Anne Lammert, Beatrice Kuhlin, Richard Birk, Karl Hörmann, Christoph Aderhold
BACKGROUND: The validation of potential molecular targets in head and neck squamous cell carcinoma (SCC) is mandatory. β-Catenin and E-cadherin are crucial for cancer progression through epithelial-mesenchymal transition. We analyzed the effect of the tyrosine kinase inhibitors nilotinib, dasatinib, erlotinib and gefitinib on β-catenin and E-cadherin expression in SCC with respect to human papillomavirus (HPV) status. MATERIALS AND METHODS: Expression of β-catenin and E-cadherin in cell lines UMSCC 11A, UMSCC 14C and CERV196 under the influence of tyrosine kinase inhibitors were analyzed by enzyme-linked immunosorbent assay...
June 2017: Anticancer Research
https://www.readbyqxmd.com/read/28551591/evidence-that-anhedonia-is-a-symptom-of-opioid-dependence-associated-with-recent-use
#8
Joshua B B Garfield, Sue M Cotton, Nicholas B Allen, Ali Cheetham, Marni Kras, Murat Yücel, Dan I Lubman
BACKGROUND: Anhedonia is prevalent among substance-dependent populations. The hedonic allostasis model suggests this is due to the effects of addictive substances on neural substrates of reward processing. However, previous research may have been confounded by other factors likely to influence anhedonia, including tobacco use, psychopathology, and history of trauma and other stressors. Thus it remains unclear whether elevated anhedonia in substance-dependent populations is caused by substance use itself, or is due to other correlates of substance dependence...
May 17, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28551585/lethal-and-sub-lethal-evaluation-of-indigo-carmine-dye-and-byproducts-after-tio2-photocatalysis-in-the-immune-system-of-eisenia-andrei-earthworms
#9
Patrícia Christina Genázio Pereira, Roberta Valoura Reimão, Thelma Pavesi, Enrico Mendes Saggioro, Josino Costa Moreira, Fábio Veríssimo Correia
The Indigo carmine (IC) dye has been widely used in textile industries, even though it has been considered toxic for rats, pigs and humans. Owing to its toxicity, wastes containing this compound should be treated to minimize or eliminate their toxic effects on the biota. As an alternative to wastewater treatment, advanced oxidative processes (AOPs) have been highlighted due to their high capacity to destruct organic molecules. In this context, this study aimed to evaluate Indigo Carmine toxicity to soil organisms using the earthworm Eisenia andrei as a model-organism and also verify the efficiency of AOP in reducing its toxicity to these organisms...
May 25, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28551532/effects-of-tryptophan-kynurenine-and-kynurenic-acid-exerted-on-human-reconstructed-corneal-epithelium-in-vitro
#10
Anna Matysik-Woźniak, Roman Paduch, Waldemar A Turski, Ryszard Maciejewski, Anselm G Jünemann, Robert Rejdak
BACKGROUND: Tryptophan metabolites formed along kynurenine pathway may affect cell proliferation and tissue function. This pathway presents potential sites for drug discovery. Tryptophan and its metabolites kynurenine and kynurenic acid may be involved in the physiology and pathology of the ocular surface. The purpose of this work is to investigate the effect exerted by tryptophan, kynurenine and kynurenic acid upon corneal epithelium. METHODS: A SkinEthic™ HCE human reconstructed corneal epithelium model was used...
February 24, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/28551513/eu-iii-functionalized-in-mof-in-oh-bpydc-as-fluorescent-probe-for-highly-selectively-sensing-organic-small-molecules-and-anions-especially-for-chcl3-and-mno4
#11
Jing-Xing Wu, Bing Yan
A highly fluorescent metal-organic framework (In-MOF, In(OH)bpydc (bpydc=biphenyl-5,5'-dicarboxylate)) imparting additional luminescent Eu(3+) ions has been synthesized for sensing organic molecules and anions, especially chloroform and MnO4(-), both of them have a significant spectral response. This Eu(3+)-incorporated hybrid (In-MOF-Eu) has been fully characterized, which reveals large surface area, great pore size, favorable thermal stability, excellent luminescence as well as good fluorescence stability...
May 19, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28551458/maternal-substance-use-and-child-protection-a-rapid-evidence-assessment-of-factors-associated-with-loss-of-child-care
#12
REVIEW
Martha Canfield, Polly Radcliffe, Sally Marlow, Marggie Boreham, Gail Gilchrist
This article reviews the literature on the factors associated with mothers who use substances losing care of their children. A rapid evidence assessment was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta Analyses. Medline and PsycINFO databases were searched to identify primary research studies published in English during January 2000-September 2016. Studies were included if they presented individual, formal support (e.g., receiving substance use treatment) or informal support (e...
May 25, 2017: Child Abuse & Neglect
https://www.readbyqxmd.com/read/28551434/impact-of-phosphate-solubilizing-bacteria-inoculation-methods-on-phosphorus-transformation-and-long-term-utilization-in-composting
#13
Yuquan Wei, Yue Zhao, Yuying Fan, Qian Lu, Mingxiao Li, Qingbin Wei, Yi Zhao, Zhenyu Cao, Zimin Wei
This study aimed to assess the effect of phosphate-solubilizing bacteria (PSB) application and inoculation methods on rock phosphate (RP) solubilization and bacterial community during composting. The results showed that PSB inoculation in different stages of composting, especially both in the beginning and cooling stages, not only improved the diversity and abundance of PSB and bacterial community, but also distinctly increased the content of potential available phosphorus. Redundancy analysis indicated that the combined inoculation of PSB in the initial stage with higher inoculation amount and in the cooling stage with lower inoculation amount was the best way to improve the inoculation effect and increase the solubilization and utilization of RP during composting...
May 19, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28551363/salamanders-on-the-bench-a-biocompatibility-study-of-salamander-skin-secretions-in-cell-cultures
#14
Janek von Byern, Dietrich Mebs, Egon Heiss, Ursula Dicke, Oliver Wetjen, Kristin Bakkegard, Ingo Grunwald, Susanne Wolbank, Severin Mühleder, Alfred Gugerell, Heidemarie Fuchs, Sylvia Nuernberger
Salamanders have evolved a wide variety of antipredator mechanisms and behavior patterns, including toxins and noxious or adhesive skin secretions. The high bonding strength of the natural bioadhesives makes these substances interesting for biomimetic research and applications in industrial and medical sectors. Secretions of toxic species may help to understand the direct effect of harmful substances on the cellular level. In the present study, the biocompatibility of adhesive secretions from four salamander species (Plethodon shermani, Plethodon glutinosus, Ambystoma maculatum, Ambystoma opacum) were analyzed using the MTT assay in cell culture and evaluated against toxic secretions of Pleurodeles waltl, Triturus carnifex, Pseudotriton ruber, Tylototriton verrucosus, and Salamandra salamandra...
May 24, 2017: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/28551126/rapid-in-vivo-determination-of-tetrodotoxin-in-pufferfish-fugu-muscle-by-solid-phase-microextraction-coupled-to-high-performance-liquid-chromatography-tandem-mass-spectrometry
#15
Le Chen, Junlang Qiu, Yijia Tang, Jianqiao Xu, Shuyao Huang, Yuan Liu, Gangfeng Ouyang
Tetrodotoxin (TTX) is one of the most toxic substances of non-protein in nature. In present study, a rapid and sensitive method based on in vivo solid-phase microextraction (SPME) coupled to liquid chromatography tandem mass spectrometry (LC-MS/MS) was developed to detect the endogenous TTX in pufferfish (Fugu). Fiber evaluation experiments demonstrated that, compared with the commercial PDMS and PA fibers, the home-made electrospun PS@PDA-GA fibers exhibited much better extraction performance towards to TTX in water (120 times and 20 times, respectively), under the optimized conditions...
August 15, 2017: Talanta
https://www.readbyqxmd.com/read/28550953/perinatal-risk-and-protective-factors-for-pediatric-abusive-head-trauma-a-multicenter-case-control-study
#16
Patrick Kelly, John M D Thompson, Jean Koh, Shanthi Ameratunga, Timothy Jelleyman, Teuila M Percival, Hinemoa Elder, Edwin A Mitchell
OBJECTIVE: To estimate associations between factors recorded in pregnancy and the first week of life and subsequent abusive head trauma. STUDY DESIGN: Multicenter, retrospective case-control study of perinatal records from 142 cases of abusive head trauma and 550 controls, matched by date and hospital of birth from 1991 to 2010. Multiple logistic regression assessed the relationship between perinatal exposures and abusive head trauma. RESULTS: The risk of abusive head trauma decreased with increasing maternal age (OR, 0...
May 24, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28550899/combined-effect-of-substance-p-and-curcumin-on-cutaneous-wound-healing-in-diabetic-rats
#17
Vinay Kant, Dinesh Kumar, Raju Prasad, Anu Gopal, Nitya N Pathak, Pawan Kumar, Surender K Tandan
BACKGROUND: Our earlier studies demonstrated that topically applied substance P (SP) or curcumin on excision skin wound accelerated the wound healing in streptozotocin-induced diabetic rats. In the present study, we aimed to evaluate the wound healing potential of combination of SP and curcumin in diabetic rats. MATERIALS AND METHODS: Open cutaneous excision wound was created on the back of each of the 60 diabetic rats. Wound-inflicted rats were equally divided into three groups namely, control, gel treated, and SP + curcumin treated...
May 15, 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/28550801/the-nk-1-receptor-antagonist-l-732-138-induces-apoptosis-in-human-gastrointestinal-cancer-cell-lines
#18
Miguel Muñoz, Marisa Rosso, Rafael Coveñas
BACKGROUND: Gastric and colon cancer cells express the neurokinin-1 receptor (NK-1R) and the peptide substance P (SP), after binding to this receptor, elicits the proliferation of gastrointestinal cancer cells and an antiapoptotic effect. In these cells, NK-1R antagonists (L-733,060: a piperidine derivative; aprepitant: a morpholine derivative) block, after binding to the NK-1R, the action of SP and exert an antiproliferative action, both antagonists promote apoptosis and the death of cancer cells...
February 12, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/28550643/housing-experiences-among-opioid-dependent-criminal-justice-involved-individuals-in-washington-d-c
#19
Alese Wooditch, Mary Mbaba, Marissa Kiss, William Lawson, Faye Taxman, Frederick L Altice
Residential mobility and type of housing contributes to an individual's likelihood and frequency of drug/alcohol use and committing criminal offenses. Little research has focused simultaneously on the influence of housing status on the use of drugs and criminal behavior. The present study examines how residential mobility (transitions in housing) and recent housing stability (prior 30 days) correlates with self-reported criminal activity and drug/alcohol use among a sample of 504 addicted, treatment-seeking opioid users with a history of criminal justice involvement...
May 26, 2017: Journal of Urban Health: Bulletin of the New York Academy of Medicine
https://www.readbyqxmd.com/read/28550631/study-on-substrate-metabolism-process-of-saline-waste-sludge-and-its-biological-hydrogen-production-potential
#20
Zengshuai Zhang, Liang Guo, Qianqian Li, Yangguo Zhao, Mengchun Gao, Zonglian She
With the increasing of high saline waste sludge production, the treatment and utilization of saline waste sludge attracted more and more attention. In this study, the biological hydrogen production from saline waste sludge after heating pretreatment was studied. The substrate metabolism process at different salinity condition was analyzed by the changes of soluble chemical oxygen demand (SCOD), carbohydrate and protein in extracellular polymeric substances (EPS), and dissolved organic matters (DOM). The excitation-emission matrix (EEM) with fluorescence regional integration (FRI) was also used to investigate the effect of salinity on EPS and DOM composition during hydrogen fermentation...
May 26, 2017: Environmental Science and Pollution Research International
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