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https://www.readbyqxmd.com/read/28926842/pharmacotherapy-with-thymoquinone-improved-pancreatic-%C3%AE-cell-integrity-and-functional-activity-enhanced-islets-revascularization-and-alleviated-metabolic-and-hepato-renal-disturbances-in-streptozotocin-induced-diabetes-in-rats
#1
Adel Galal El-Shemi, Osama Adnan Kensara, Aiman Alsaegh, Mohammed Hasan Mukhtar
AIMS: This study is aimed at evaluating the antidiabetic effects of thymoquinone (TQ) on streptozotocin (STZ)-induced diabetes in rats, and exploring the possible underlying mechanisms. METHODS: Diabetes was induced in adult male Wistar rats by intraperitoneal injection of freshly prepared STZ (65 mg/kg). After disease induction, 42 rats were equally assigned to: controls, STZ-diabetic group, and STZ-diabetic group treated with oral TQ (35 mg/kg/day) for 5 weeks...
September 20, 2017: Pharmacology
https://www.readbyqxmd.com/read/28926811/towards-better-monitoring-of-technology-critical-elements-in-europe-coupling-of-natural-and-anthropogenic-cycles
#2
Philip Nuss, Gian Andrea Blengini
The characterization of elemental cycles has a rich history in biogeochemistry. Well known examples include the global carbon cycle, or the cycles of the 'grand nutrients' nitrogen, phosphorus, and sulfur. More recently, efforts have increased to better understand the natural cycling of technology critical elements (TCEs), i.e. elements with a high supply risk and economic importance in the EU. On the other hand, tools such as material-flow analysis (MFA) can help to understand how substances and goods are transported and accumulated in man-made technological systems ('anthroposphere')...
September 16, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28926808/active-pharmaceutical-ingredients-entering-the-aquatic-environment-from-wastewater-treatment-works-a-cause-for-concern
#3
Sean Comber, Mike Gardner, Pernilla Sörme, Dean Leverett, Brian Ellor
This work reports on the variation in wastewater treatment works (WwTW) influent concentrations of a wide variety of active pharmaceutical ingredients (APIs), their removal efficiency, effluent concentrations and potential risks to the aquatic environment. The research is based on data generated from two large UK-wide WwTW monitoring programmes. Taking account of removal of parent compound from the aqueous phase during treatment in combination with estimates of dilution available it is possible to prioritise the APIs of greatest risk of exceeding estimates of predicted no effect concentrations (PNEC) in receiving waters for all WwTW in the UK...
September 16, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28926768/the-effect-of-irrigation-time-and-type-of-irrigation-fluid-on-cartilage-surface-friction
#4
F Stärke, F Awiszus, C H Lohmann, C Stärke
It is known that fluid irrigation used during arthroscopic procedures causes a wash-out of lubricating substances from the articular cartilage surface and leads to increased friction. It was the goal of this study to investigate whether this effect depends on the time of irrigation and type of fluid used. Rabbit hind legs were used for the tests. The knees were dissected and the friction coefficient of the femoral cartilage measured against glass in a boundary lubrication state. To determine the influence of irrigation time and fluid, groups of 12 knees received either no irrigation (control), 15, 60 or 120min of irrigation with lactated Ringer's solution or 60min of irrigation with normal saline or a sorbitol/mannitol solution...
September 9, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28926734/a-quality-by-design-based-approach-to-a-capillary-electrokinetic-assay-for-the-determination-of-dextromepromazine-and-levomepromazine-sulfoxide-as-impurities-of-levomepromazine
#5
Stephan Niedermeier, Gerhard K E Scriba
Using a quality by design approach, a capillary electrophoresis method for the simultaneous determination of dextromepromazine and the oxidation product levomepromazine sulfoxide in levomepromazine was developed. The analytical target profile was defined that the method should be able to quantify 0.1% of both impurities with a precision of  ≤10%. Hydroxypropyl-γ-cyclodextrin was used as chiral selector. The critical process parameters cyclodextrin concentration, buffer pH and concentration as well as temperature and applied voltage were studied using a fractional factorial resolution V+ design for defining the knowledge space...
September 8, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28926674/prior-mental-disorders-and-lifetime-suicidal-behaviors-among-us-army-soldiers-in-the-army-study-to-assess-risk-and-resilience-in-servicemembers-army-starrs
#6
Alexander J Millner, Robert J Ursano, Irving Hwang, Andrew J King, James A Naifeh, Nancy A Sampson, Alan M Zaslavsky, Murray B Stein, Ronald C Kessler, Matthew K Nock
We report on associations of retrospectively reported temporally prior mental disorders and Army career characteristics with subsequent first onset of suicidal behaviors in a large, representative sample of US Army soldiers who participated in the Consolidated All-Army Survey of the Army Study to Assess Risk and Resilience in Servicemembers (N = 29,982). Results reveal that among men and women, all self-reported lifetime disorders measured (some assessed with screening scales) are associated with subsequent onset of suicide ideation...
September 19, 2017: Suicide & Life-threatening Behavior
https://www.readbyqxmd.com/read/28926484/alcohol-and-drug-use-before-and-during-the-first-year-after-traumatic-brain-injury
#7
Simon Beaulieu-Bonneau, Frédéric St-Onge, Marie-Claude Blackburn, Andrée Banville, Andrée-Anne Paradis-Giroux, Marie-Christine Ouellet
OBJECTIVES: To compare individuals with mild and moderate/severe traumatic brain injury (TBI) on alcohol and drug use and substance use disorders before and in the first year post-TBI; to explore sociodemographic and injury-related variables associated with substance use disorders. PARTICIPANTS: A total of 225 adults hospitalized in a level I trauma center after TBI. DESIGN: Observational cohort study with retrospective (pre-TBI) and prospective (4, 8, and 12 months post-TBI) assessments...
September 18, 2017: Journal of Head Trauma Rehabilitation
https://www.readbyqxmd.com/read/28926353/randomized-double-blind-placebo-and-active-comparator-controlled-crossover-study-evaluating-the-abuse-potential-of-the-antiepileptic-drug-lacosamide-in-healthy-recreational-drug-users
#8
Kerri A Schoedel, Jens-Otto Andreas, Pamela Doty, Klaus Eckhardt, Edward M Sellers
PURPOSE: This phase 1, randomized, double-blind, placebo- and active comparator-controlled crossover study assessed the abuse potential of the antiepileptic drug, lacosamide. METHODS: After a qualification phase, 38 healthy, recreational central nervous system-depressant users were randomized to treatment sequences comprising single oral therapeutic (200 mg) and supratherapeutic (800 mg) doses of lacosamide, alprazolam (1.5 and 3 mg), and placebo. Subjective effects were assessed for 24 hours following each dose using a range of scales, with a 5- to 9-day washout between treatments...
September 18, 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28926304/substance-use-in-youth-with-borderline-personality-disorder
#9
Franco Scalzo, Carol A Hulbert, Jennifer K Betts, Sue M Cotton, Andrew M Chanen
Co-occurring substance misuse and borderline personality disorder (BPD) in adults is associated with more severe dysfunction and poorer prognosis than BPD alone. However, it is unknown to what extent substance use in youth with BPD is normative for this age group or pathological. This study compared substance use in 117 help-seeking youth (aged 15-25 years) with their first presentation for treatment of BPD, with an epidemiological general population sample and with healthy, age- and gender-matched controls...
September 19, 2017: Journal of Personality Disorders
https://www.readbyqxmd.com/read/28926236/biofilms-benefiting-plants-exposed-to-zno-and-cuo-nps-studied-with-a-root-mimetic-hollow-fiber-membrane
#10
Michelle Bonebrake, Kaitlyn C Anderson, Jonathan Valiente, Astrid Rosa Jacobson, Joan E McLean, Anne J Anderson, David W Britt
Plants exist with a consortium of microbes that influence plant health, including response to biotic and abiotic stress. While nanoparticle (NP) - plant interactions are increasingly studied, the effect of NPs on the plant microbiome is less researched. Here a root-mimetic hollow fiber membrane (HFM) is presented for generating biofilms of plant-associated microbes nurtured by artificial root exudates (AREs) to correlate exudate composition with biofilm formation and response to NPs. Two microbial isolates from field-grown wheat, a bacillus endophyte and a pseudomonad root surface colonizer, were examined on HFMs fed with AREs varying in N and C composition...
September 19, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28925969/caffeine-improves-basketball-performance-in-experienced-basketball-players
#11
Carlos Puente, Javier Abián-Vicén, Juan José Salinero, Beatriz Lara, Francisco Areces, Juan Del Coso
The aim of this study was to determine the effect of caffeine intake on overall basketball performance in experienced players. A double-blind, placebo-controlled, randomized experimental design was used for this investigation. In two different sessions separated by one week, 20 experienced basketball players ingested 3 mg of caffeine/kg of body mass or a placebo. After 60 min, participants performed 10 repetitions of the following sequence: Abalakov jump, Change-of-Direction and Acceleration Test (CODAT) and two free throws...
September 19, 2017: Nutrients
https://www.readbyqxmd.com/read/28925959/preventing-surgical-site-infections-using-a-natural-biodegradable-antibacterial-coating-on-surgical-sutures
#12
Jochen Reinbold, Ann-Kristin Uhde, Ingrid Müller, Tobias Weindl, Jürgen Geis-Gerstorfer, Christian Schlensak, Hans-Peter Wendel, Stefanie Krajewski
Surgical site infections (SSIs) are one of the most common nosocomial infections, which can result in serious complications after surgical interventions. Foreign materials such as implants or surgical sutures are optimal surfaces for the adherence of bacteria and subsequent colonization and biofilm formation. Due to a significant increase in antibiotic-resistant bacterial strains, naturally occurring agents exhibiting antibacterial properties have great potential in prophylactic therapies. The aim of this study was to develop a coating for surgical sutures consisting of the antibacterial substance totarol, a naturally occurring diterpenoid isolated from Podocarpustotara in combination with poly(lactide-co-glycolide acid) (PLGA) as a biodegradable drug delivery system...
September 19, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28925942/application-of-surface-protective-coating-to-enhance-environment-withstanding-property-of-the-mems-2d-wind-direction-and-wind-speed-sensor
#13
Kyu-Sik Shin, Dae-Sung Lee, Sang-Woo Song, Jae Pil Jung
In this study, a microelectromechanical system (MEMS) two-dimensional (2D) wind direction and wind speed sensor consisting of a square heating source and four thermopiles was manufactured using the heat detection method. The heating source and thermopiles of the manufactured sensor must be exposed to air to detect wind speed and wind direction. Therefore, there are concerns that the sensor could be contaminated by deposition or adhesion of dust, sandy dust, snow, rain, and so forth, in the air, and that the membrane may be damaged by physical shock...
September 19, 2017: Sensors
https://www.readbyqxmd.com/read/28925892/natural-active-compounds-from-plant-food-and-chinese-herbal-medicine-for-nonalcoholic-fatty-liver-disease
#14
Qian Liu, Lixin Zhu, Chen Cheng, Yiyang Hu, Qin Feng
Nonalcoholic fatty liver disease (NAFLD) has become more prevalent worldwide. It is often associated with some metabolic diseases, such as obesity, type 2 diabetes, and metabolic syndrome. With increasing focus on the treatment of fatty liver, much attention has been paid to numerous medicinal herbs and dietary substances to provide a new strategy for NAFLD treatment. The natural active compounds from the herbs or diet have been studied as promising treatments for NAFLD. This study aimed to summarize the use and mechanism of action of natural active compounds in the treatment of NAFLD in the recent 10 years...
September 18, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28925679/substance-p-mediated-dgls-complexing-with-dachpt-for-targeting-therapy-of-glioma
#15
Tao Sun, Xutao Jiang, Qingbing Wang, Qinjun Chen, Yifei Lu, Lisha Liu, Yu Zhang, Xi He, Chunhui Ruan, Yujie Zhang, Qin Guo, Yaohua Liu, Chen Jiang
Currently, glioblastoma (glioma) is described as the deadliest brain tumor for its invasive natural with exceeding difficulty in surgical excision. Blood-brain barrier (BBB) can restrict the penetration of most therapeutic reagents including platinum (Pt)-based drugs-the most widely used reagents in clinical trials for their revolutionized cancer chemotherapy against a broad range of tumors. Nanomedicine represents a promising strategy for the intravenous delivery of Pt-based drugs into the brain. In this research, with the aim of malignant glioma treatment by Pt-based drugs, a novel nano drug carrier was developed: dendrigraft poly-L-lysines (DGLs) was PEGylated, linked with diethylenetriaminpentaacetic acid (DTPA) to complex (1,2-diaminocyclohexane)platinum(II) (DACHPt), and modified with Substance P (SP) as a BBB/glioma dual-targeting moiety...
September 19, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28925552/in-situ-bone-tissue-engineering-with-an-endogenous-stem-cell-mobilizer-and-osteoinductive-nanofibrous-polymeric-scaffolds
#16
Jong Seung Lee, Yoonhee Jin, Hyun-Ji Park, Kisuk Yang, Min Suk Lee, Hee Seok Yang, Seung-Woo Cho
Classical bone tissue engineering involves the use of culture-expanded cells and scaffolds to produce tissue constructs for transplantation. Despite promising results, clinical adoption of these constructs has been limited due to various drawbacks, including extensive cell expansion steps, low cell survival rate upon transplantation, and the possibility of immuno-rejection. To bypass the ex vivo cell culture and transplantation process, we exploited the regenerative capacity of the host by mobilizing endogenous stem cells to the site of injury...
September 19, 2017: Biotechnology Journal
https://www.readbyqxmd.com/read/28925377/applied-upper-airway-resistance-instantly-affects-breath-components-a-unique-insight-into-pulmonary-medicine
#17
Pritam Sukul, Jochen Schubert, Svend Kamysek, Phillip Trefz, Wolfram Miekisch
Respiratory parameters such as flow or rate have complex effects onto exhalation of volatile substances and can hamper clinical interpretation of breath biomarkers. We investigated effects of progressively applied upper-airway resistances onto exhalation of volatile organic compounds (VOCs) in healthy humans. We performed real-time mass-spectrometric determination of breath volatiles in 50 subjects with parallel non-invasive hemodynamic monitoring, breath-resolved spirometry and capnometry during controlled tidal breathing (12 breaths/min)...
September 19, 2017: Journal of Breath Research
https://www.readbyqxmd.com/read/28925343/developmental-pathways-from-maltreatment-to-risk-behavior-sexual-behavior-as-a-catalyst
#18
Sonya Negriff
Although delinquency, substance use, and sexual activity are established to be highly intercorrelated, the extant research provides minimal evidence in support of one particular sequence of risk behavior or on the cascade effects from maltreatment. The present study tested a longitudinal model incorporating maltreatment, deviant peers, sexual behavior, delinquency, and substance use to elucidate the sequential pathway(s) from maltreatment to each specific risk behavior throughout adolescence. Data came from a longitudinal study on the effects of maltreatment on adolescent development (N = 454) with four study assessments from early (Time 1 M age = 10...
September 19, 2017: Development and Psychopathology
https://www.readbyqxmd.com/read/28925139/-rapid-identification-and-evaluation-of-chinese-materia-medica-quality-by-near-infrared-spectroscopy
#19
Gang Bai, Guo-Yu Ding, Yuan-Yuan Hou, Min Jiang, Jie Gao
In recent years, the research object of traditional Chinese medicine(TCM) analysis has not just been limited to the common analysis technology, but focused on the key relationship between chemical ingredients and traditional functions, including Chinese material medica (CMM) attributes, chemical substance and biological function. Near infrared spectroscopy (NIR) analysis technology, due to its unique advantages, has been developed rapidly in the field of pharmaceutical analysis, especially in the TCM analysis...
October 2016: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28925026/characterizing-community-courts
#20
Tali Gal, Hadar Dancig-Rosenberg
Community courts (CCs) provide a therapeutic diversion for repeat low-level offenders. This article explores the characteristics of two Israeli CCs using the Criminal Law Taxonomy (CLT), an instrument developed by the authors for assessing process-, stakeholder-, substance-, and outcomes-related characteristics of criminal justice mechanisms. Through court-hearing observations and a process of multi-rater coding of cases, the article analyzes the courtroom dynamics according to a set of 13 measurable parameters...
September 18, 2017: Behavioral Sciences & the Law
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