Esther E E Drees, Margaretha G M Roemer, Nils J Groenewegen, Jennifer Perez-Boza, Monique A J van Eijndhoven, Leah I Prins, Sandra A W M Verkuijlen, Xuan-Mai Tran, Julia Driessen, G J C Zwezerijnen, Phylicia Stathi, Kevin Mol, Joey J J P Karregat, Aikaterini Kalantidou, Andrea Vallés-Martí, T J Molenaar, Ernesto Aparicio-Puerta, Erik van Dijk, Bauke Ylstra, Catharina G M Groothuis-Oudshoorn, Michael Hackenberg, Daphne de Jong, Josée M Zijlstra, D Michiel Pegtel
Minimally-invasive tools to assess tumour presence and burden may improve clinical management. FDG-PET (metabolic) imaging is the current gold standard for interim response assessment in patients with classical Hodgkin Lymphoma (cHL), but this technique cannot be repeated frequently. Here we show that microRNAs (miRNA) associated with tumour-secreted extracellular vesicles (EVs) in the circulation of cHL patients may improve response assessment. Small RNA sequencing and qRT-PCR reveal that the relative abundance of cHL-expressed miRNAs, miR-127-3p, miR-155-5p, miR-21-5p, miR-24-3p and let-7a-5p is up to hundred-fold increased in plasma EVs of cHL patients pre-treatment when compared to complete metabolic responders (CMR)...
July 2021: Journal of Extracellular Vesicles