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https://www.readbyqxmd.com/read/27933673/a-biophysical-and-computational-study-unraveling-the-molecular-interaction-mechanism-of-a-new-janus-kinase-inhibitor-tofacitinib-with-bovine-serum-albumin
#1
Ali Saber Abdelhameed, Saima Nusrat, Mohammad Rehan Ajmal, Syed Mohammad Zakariya, Masihuz Zaman, Rizwan Hasan Khan
The interaction of a recently certified kinase inhibitor Tofacitinib (TFB) with bovine serum albumin (BSA) has been studied, by spectroscopic and molecular docking studies. Spectrofluorimetric measurements at 3 different temperatures (288, 298, and 310 K) showed that TFB quench the intrinsic fluorescence of BSA upon forming a nonfluorescent complex. The intrinsic fluorescence data showed that TFB binds to BSA with binding constant (Kb ) of approximately 10(4) M(-1) , affirming a significant affinity of TFB with BSA...
December 9, 2016: Journal of Molecular Recognition: JMR
https://www.readbyqxmd.com/read/27933424/-home-practice-is-the-program-parents-practice-of-program-skills-as-predictors-of-outcomes-in-the-new-beginnings-program-effectiveness-trial
#2
Cady Berkel, Irwin N Sandler, Sharlene A Wolchik, C Hendricks Brown, Carlos G Gallo, Amanda Chiapa, Anne M Mauricio, Sarah Jones
An examination of the content and processes of evidence-based programs is critical for empirically evaluating theories about how programs work, the "action theory" of the program (West et al. in American Journal of Community Psychology, 21, 571-605, 1993). The New Beginnings Program (NBP; Wolchik et al., 2007), a parenting-after-divorce preventive intervention, theorizes that program-induced improvements in parenting across three domains: positive relationship quality, effective discipline, and protecting children from interparental conflict, will reduce the negative outcomes that are common among children from divorced families...
December 8, 2016: Prevention Science: the Official Journal of the Society for Prevention Research
https://www.readbyqxmd.com/read/27933179/associations-between-genetics-medical-status-physical-exercise-and-psychological-well-being-in-adults-with-cystic-fibrosis
#3
Lena Backström-Eriksson, Agneta Bergsten-Brucefors, Lena Hjelte, Bo Melin, Kimmo Sorjonen
BACKGROUND: Cystic fibrosis (CF) is the most common autosomal recessive, life-shortening disease among people of European origin. Type of genetic mutation and regular physical exercise has an impact on clinical outcome. This cross-sectional study explores the associations between genetics, medical status, physical exercise and psychological well-being in adult patients with CF. METHODS: Adult patients with CF (N=68; mean age: 32.2; range 18-67 years; 46% women) completed the Cystic Fibrosis Questionnaire-Revised and Hospital Anxiety Depression Scale...
2016: BMJ Open Respiratory Research
https://www.readbyqxmd.com/read/27933090/the-worldwide-spread-of-the-tiger-mosquito-as-revealed-by-mitogenome-haplogroup-diversity
#4
Vincenza Battaglia, Paolo Gabrieli, Stefania Brandini, Marco R Capodiferro, Pio A Javier, Xiao-Guang Chen, Alessandro Achilli, Ornella Semino, Ludvik M Gomulski, Anna R Malacrida, Giuliano Gasperi, Antonio Torroni, Anna Olivieri
In the last 40 years, the Asian tiger mosquito Aedes albopictus, indigenous to East Asia, has colonized every continent except Antarctica. Its spread is a major public health concern, given that this species is a competent vector for numerous arboviruses, including those causing dengue, chikungunya, West Nile, and the recently emerged Zika fever. To acquire more information on the ancestral source(s) of adventive populations and the overall diffusion process from its native range, we analyzed the mitogenome variation of 27 individuals from representative populations of Asia, the Americas, and Europe...
2016: Frontiers in Genetics
https://www.readbyqxmd.com/read/27933040/dnra-and-denitrification-coexist-over-a-broad-range-of-acetate-n-no3-ratios-in-a-chemostat-enrichment-culture
#5
Eveline M van den Berg, Marissa Boleij, J Gijs Kuenen, Robbert Kleerebezem, Mark C M van Loosdrecht
Denitrification and dissimilatory nitrate reduction to ammonium (DNRA) compete for nitrate in natural and engineered environments. A known important factor in this microbial competition is the ratio of available electron donor and elector acceptor, here expressed as Ac/N ratio (acetate/nitrate-nitrogen). We studied the impact of the Ac/N ratio on the nitrate reduction pathways in chemostat enrichment cultures, grown on acetate mineral medium. Stepwise, conditions were changed from nitrate limitation to nitrate excess in the system by applying a variable Ac/N ratio in the feed...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27933031/exhaustion-experiences-in-junior-athletes-the-importance-of-motivation-and-self-control-competencies
#6
Gro Jordalen, Pierre-Nicolas Lemyre, Natalie Durand-Bush
Quality of motivation, self-control competencies, as well as past performance experience influence sport participation outcomes in developing athletes. Studies have shown that junior athletes high in self-determined motivation are less prone to experience burnout, while self-control competencies help developing athletes to be conscious and deliberate in their self-regulatory efforts toward elite sport performances and avoid negative sport participation outcomes. Combining the self-determination theory framework and psychosocial theories of self-regulation, the aim of this cross-sectional study was to examine how various types of motivation and self-control competencies together are associated with the development of burnout symptoms in junior athletes...
2016: Frontiers in Psychology
https://www.readbyqxmd.com/read/27932985/pregnane-x-receptor-pxr-mediated-gene-repression-and-cross-talk-of-pxr-with-other-nuclear-receptors-via-coactivator-interactions
#7
REVIEW
Petr Pavek
Pregnane X receptor is a ligand-activated nuclear receptor (NR) that mainly controls inducible expression of xenobiotics handling genes including biotransformation enzymes and drug transporters. Nowadays it is clear that PXR is also involved in regulation of intermediate metabolism through trans-activation and trans-repression of genes controlling glucose, lipid, cholesterol, bile acid, and bilirubin homeostasis. In these processes PXR cross-talks with other NRs. Accumulating evidence suggests that the cross-talk is often mediated by competing for common coactivators or by disruption of coactivation and activity of other transcription factors by the ligand-activated PXR...
2016: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/27932630/hospital-doctors-understanding-of-use-and-withdrawal-of-the-liverpool-care-pathway-a-qualitative-study-of-practice-based-experiences-during-times-of-change
#8
Sharon Twigger, Sarah J Yardley
BACKGROUND: The Liverpool Care Pathway was used in UK hospitals (late 1990s to July 2014) in an attempt to generate hospice-style high-quality end-of-life care in acute settings. Despite being widely established, there was limited research or contextual evidence regarding this approach or its impact. Growing criticism from the public, media, politicians and healthcare professionals culminated with a critical independent review (July 2013) and subsequent withdrawal of the Liverpool Care Pathway...
December 8, 2016: Palliative Medicine
https://www.readbyqxmd.com/read/27932589/sex-and-race-ethnicity-differences-in-following-dietary-and-exercise-recommendations-for-u-s-representative-sample-of-adults-with-type-2-diabetes
#9
Joan A Vaccaro, Fatma G Huffman
This study examined sex by race/ethnicity differences in medical advice received for diet and exercise with corresponding health behaviors of a U.S. representative sample of adults with type 2 diabetes (N = 1,269). Data from the National Health and Nutrition Examination Surveys for 2011-2014 for 185 Mexican Americans, 123 Other Hispanics, 392 non-Hispanic Blacks, 140 non-Hispanic Asians, and 429 non-Hispanic Whites were analyzed using logistic regression analyses. Reporting being given dietary and exercise advice was positively associated with reporting following the behavior...
December 7, 2016: American Journal of Men's Health
https://www.readbyqxmd.com/read/27932551/antigen-unmasking-enhances-visualization-efficacy-of-the-oocyte-activation-factor-phospholipase-c-zeta-in-mammalian-sperm
#10
Junaid Kashir, Luke Buntwal, Michail Nomikos, Brian L Calver, Panagiotis Stamatiadis, Peter Ashley, Vyronia Vassilakopoulou, David Sanders, Paul Knaggs, Evangelia Livaniou, Adnan Bunkheila, Karl Swann, F Anthony Lai
STUDY QUESTION: Is it possible to improve clinical visualization of phospholipase C zeta (PLCζ) as a diagnostic marker of sperm oocyte activation capacity and male fertility? SUMMARY ANSWER: Poor PLCζ visualization efficacy using current protocols may be due to steric or conformational occlusion of native PLCζ, hindering antibody access, and is significantly enhanced using antigen unmasking/retrieval (AUM) protocols. WHAT IS KNOWN ALREADY: Mammalian oocyte activation is mediated via a series of intracellular calcium (Ca(2+)) oscillations induced by sperm-specific PLCζ...
December 8, 2016: Molecular Human Reproduction
https://www.readbyqxmd.com/read/27932549/proteolytic-degradation-of-heat-shock-protein-a2-occurs-in-response-to-oxidative-stress-in-male-germ-cells-of-the-mouse
#11
Elizabeth G Bromfield, R John Aitken, Eileen A McLaughlin, Brett Nixon
STUDY QUESTION: Does oxidative stress compromise the protein expression of heat shock protein A2 (HSPA2) in the developing germ cells of the mouse testis? SUMMARY ANSWER: Oxidative stress leads to the modification of HSPA2 by the lipid aldehyde 4-hydroxynonenal (4HNE) and initiates its degradation via the ubiquitin-proteasome system. WHAT IS KNOWN ALREADY: Previous work has revealed a deficiency in HSPA2 protein expression within the spermatozoa of infertile men that have failed fertilization in a clinical setting...
December 8, 2016: Molecular Human Reproduction
https://www.readbyqxmd.com/read/27932457/structural-basis-for-the-dimerization-of-nab2-generated-by-rna-binding-provides-insight-into-its-contribution-to-both-poly-a-tail-length-determination-and-transcript-compaction-in-saccharomyces-cerevisiae
#12
Shintaro Aibara, James M B Gordon, Anja S Riesterer, Stephen H McLaughlin, Murray Stewart
In Saccharomyces cerevisiae generation of export-competent mRNPs terminates the nuclear phase of the gene expression pathway and facilitates transport to the cytoplasm for translation. Nab2 functions in this process to control both mRNP compaction that facilitates movement through nuclear pore complexes and the length of transcript poly(A) tails. Nab2 has a modular structure that includes seven CCCH Zn fingers that bind to A-rich RNAs and fingers 5-7 are critical for these functions. Here, we demonstrate, using both biophysical and structural methods, that binding A11G RNA induces dimerization of Zn fingers 5-7 mediated by the novel spatial arrangement of the fingers promoting each RNA chain binding two protein chains...
December 8, 2016: Nucleic Acids Research
https://www.readbyqxmd.com/read/27932441/trophoblast-cells-inhibit-neutrophil-extracellular-trap-formation-and-enhance-apoptosis-through-vasoactive-intestinal-peptide-mediated-pathways
#13
Guillermina Calo, Florencia Sabbione, Daiana Vota, Daniel Paparini, Rosanna Ramhorst, Analía Trevani, Claudia Pérez Leirós
STUDY QUESTION: Do human trophoblast cells modulate neutrophil extracellular trap (NET) formation, reactive oxygen species (ROS) synthesis and neutrophil apoptosis through mechanisms involving vasoactive intestinal peptide (VIP)? SUMMARY ANSWER: Trophoblast cells inhibited NET formation and ROS synthesis and enhanced neutrophil apoptosis through VIP-mediated pathways in a model of maternal-placental interaction. WHAT IS KNOWN ALREADY: Immune homeostasis maintenance at the maternal-placental interface is mostly coordinated by trophoblast cells...
December 7, 2016: Human Reproduction
https://www.readbyqxmd.com/read/27932269/the-presence-of-carcinoma-in-situ-at-radical-cystectomy-increases-the-risk-of-urothelial-recurrence-implications-for-follow-up-schemes
#14
Marco Moschini, Shahrokh F Shariat, Mohammad Abufaraj, Francesco Soria, Tobias Klatte, Giovanni La Croce, Agostino Mattei, Rocco Damiano, Andrea Salonia, Francesco Montorsi, Alberto Briganti, Renzo Colombo, Andrea Gallina
INTRODUCTION: To evaluate the incidence of carcinoma in situ (CIS) in patients treated with radical cystectomy (RC) due to bladder cancer and to assess its effect on recurrence and survival rates. METHODS: The study focused on 1,128 consecutive nonmetastatic patients with bladder cancer treated with RC at a single tertiary care referral center from 1994 to 2014. The Kaplan-Meier method was used to compare recurrence, cancer-specific mortality (CSM), and overall mortality-free rates in the overall population and in pT0-pT2 and pT3-pT4 patients after stratifying according to the presence of CIS...
December 5, 2016: Urologic Oncology
https://www.readbyqxmd.com/read/27931743/a-longitudinal-study-of-emotion-regulation-among-sexually-abused-preschoolers
#15
Ariane Séguin-Lemire, Martine Hébert, Louise Cossette, Rachel Langevin
The aim of the present study was to investigate the evolution of emotion regulation competencies in sexually abused preschoolers. Children's emotion regulation abilities and their emotional lability and negativity were assessed shortly after disclosure of sexual abuse and one year later, and compared to those of non-abused children. A sample of 47 sexually abused (37 girls, 10 boys) and 74 non-abused children (54 girls, 20 boys), aged 3-7 years (M=56.83months; SD=9.55), participated in the study. Parents and daycare educators or teachers completed the Emotion Regulation Checklist (Shields & Cicchetti, 1997) and an adapted version of the History of Victimization Form (Parent & Hébert, 2006)...
December 5, 2016: Child Abuse & Neglect
https://www.readbyqxmd.com/read/27931638/complications-of-diagnostic-and-therapeutic-endoscopic-ultrasound
#16
REVIEW
Sundeep Lakhtakia
Endoscopic Ultrasound (EUS) provides the unique opportunity to visualize, interrogate and intervene gastrointestinal (GI) luminal, mural or peri-luminal structures and pathology with negligible adverse effects. Diagnostic, upper GI and rectal EUS is feasible, extremely safe, and efficacious. Most EUS guided interventions are safe, effective and minimally invasive, compared to peers in the percutaneous radiological or surgical procedures. As with any endoscopic procedure, EUS and its guided interventions may be accompanied by adverse events...
October 2016: Best Practice & Research. Clinical Gastroenterology
https://www.readbyqxmd.com/read/27931355/comprehensive-analysis-competence-and-innovative-approaches-for-sustainable-chemical-production
#17
Joerg Appel, Corrado Colombo, Urs Dtwyler, Yun Chen, Nimet Kerimoglu
Humanity currently sees itself facing enormous economic, ecological, and social challenges. Sustainable products and production in specialty chemistry are an important strategic element to address these megatrends. In addition to that, digitalization and global connectivity will create new opportunities for the industry. One aspect is examined in this paper, which shows the development of comprehensive analysis of production networks for a more sustainable production in which the need for innovative solutions arises...
September 2016: Chimia
https://www.readbyqxmd.com/read/27931354/lonza-error-prevention-system-eps-changing-human-performance-in-pharmaceutical-operations
#18
Kerstin Bodmann, Constanze Reinhard, Michael Mdler, Kevin Tinson, Mark Johnson
Errors are a part of life. With human errors accounting for approximately 50% of quality incidents and related problems within the pharmaceutical industry, the need to improve human performance in manufacturing operations is obvious. The purpose of this article is to describe error-proofing ways of structuring and writing knowledge documents, procedures, batch records, as well as practices for structuring, conducting, and documenting training to assure competence. These practices are recommended for adoption to shift the current 'training for compliance' paradigm to a 'training for competence' paradigm...
September 2016: Chimia
https://www.readbyqxmd.com/read/27931268/an-epidemiological-analysis-of-equine-welfare-data-from-regulatory-inspections-by-the-official-competent-authorities
#19
P L Hitchens, J Hultgren, J Frössling, U Emanuelson, L J Keeling
Determining welfare status in a population is the first step in efforts to improve welfare. The primary objective of this study was to explore a new epidemiological approach for analysis of data from official competent authorities that pertain to compliance with animal welfare legislation. We reviewed data already routinely collected as part of Swedish official animal welfare inspections for 2010-13, using a checklist containing 45 checkpoints (CPs). These covered animal-, resource- and management-based measures of equine welfare...
December 9, 2016: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/27931182/exposure-of-bovine-oocytes-and-embryos-to-elevated-non-esterified-fatty-acid-concentrations-integration-of-epigenetic-and-transcriptomic-signatures-in-resultant-blastocysts
#20
K L J Desmet, V Van Hoeck, D Gagné, E Fournier, A Thakur, A M O'Doherty, C P Walsh, M A Sirard, P E J Bols, J L M R Leroy
BACKGROUND: Metabolic stress associated with negative energy balance in high producing dairy cattle and obesity in women is a risk factor for decreased fertility. Non-esterified fatty acids (NEFA) are involved in this pathogenesis as they jeopardize oocyte and embryo development. Growing evidence indicates that maternal metabolic disorders can disturb epigenetic programming, such as DNA methylation, in the offspring. Oocyte maturation and early embryo development coincide with methylation changes and both are sensitive to adverse environments...
December 8, 2016: BMC Genomics
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