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https://www.readbyqxmd.com/read/29471593/clinical-evolution-of-patients-with-new-onset-inflammatory-back-pain-a-population-based-cohort-study
#1
Runsheng Wang, Cynthia S Crowson, Kerry Wright, Michael M Ward
OBJECTIVE: Inflammatory back pain (IBP) is often an early manifestation of spondyloarthritis (SpA), but the prognosis of patients with incident IBP is unknown. We investigated the long-term outcomes of patients with IBP, and predictors of progression to SpA, in a retrospective longitudinal study of a population-based cohort. METHODS: We used the Rochester Epidemiology Project, a longstanding population-based study of residents of Olmsted County, Minnesota, USA, to identify patients aged 16 to 35 with clinical visits for back pain from 1999 to 2003...
February 22, 2018: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29471449/obesity-associated-advanced-glycation-end-products-within-the-human-uterine-cavity-adversely-impact-endometrial-function-and-embryo-implantation-competence
#2
Gabriella S Antoniotti, Melinda Coughlan, Lois A Salamonsen, Jemma Evans
STUDY QUESTION: Do obese levels of advanced glycation end products (AGEs) within the uterine cavity detrimentally alter tissue function in embryo implantation and placental development? SUMMARY ANSWER: Obese levels of AGEs activate inflammatory signaling (p65 NFκB) within endometrial epithelial cells and alter their function, cause endoplasmic reticulum (ER) stress in endometrial stromal cells and impair decidualization, compromise implantation of blastocyst mimics and inhibit trophoblast invasion...
February 20, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29471395/origin-and-composition-of-cell-free-dna-in-spent-medium-from-human-embryo-culture-during-preimplantation-development
#3
M Vera-Rodriguez, A Diez-Juan, J Jimenez-Almazan, S Martinez, R Navarro, V Peinado, A Mercader, M Meseguer, D Blesa, I Moreno, D Valbuena, C Rubio, C Simon
STUDY QUESTION: What is the origin and composition of cell-free DNA in human embryo spent culture media? SUMMARY ANSWER: Cell-free DNA from human embryo spent culture media represents a mix of maternal and embryonic DNA, and the mixture can be more complex for mosaic embryos. WHAT IS KNOWN ALREADY: In 2016, ~300 000 human embryos were chromosomally and/or genetically analyzed using preimplantation genetic testing for aneuploidies (PGT-A) or monogenic disorders (PGT-M) before transfer into the uterus...
February 20, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29471323/what-s-to-be-done-about-laboratory-quality-process-indicators-laboratory-stewardship-the-outcomes-problem-risk-assessment-and-economic-value-responding-to-contemporary-global-challenges
#4
Frederick A Meier, Tony C Badrick, Kenneth A Sikaris
Objectives: For 50 years, structure, process, and outcomes measures have assessed health care quality. For clinical laboratories, structural quality has generally been assessed by inspection. For assessing process, quality indicators (QIs), statistical monitors of steps in the clinical laboratory total testing, have proliferated across the globe. Connections between structural and process laboratory measures and patient outcomes, however, have rarely been demonstrated. Methods: To inform further development of clinical laboratory quality systems, we conducted a selective but worldwide review of publications on clinical laboratory quality assessment...
February 17, 2018: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/29471284/adverse-metabolic-effects-in-fish-exposed-to-contaminants-of-emerging-concern-in-the-field-and-laboratory
#5
James P Meador, Andrew Yeh, Evan P Gallagher
Several metabolic parameters were assessed in juvenile Chinook salmon (Oncorhynchus tshawytscha) and staghorn sculpin (Leptocottus armatus) residing in two estuaries receiving wastewater treatment effluent and one reference estuary. We also conducted a laboratory study with fish dosed for 32 days with 16 of the most common contaminants of emerging concern (CECs) detected in feral fish. Several blood chemistry parameters and other indicators of health were measured in fish from the field and laboratory study that were used to assess potential metabolic disruption...
February 19, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29471270/validation-of-time-to-task-performance-assessment-method-in-simulation-a-comparative-design-study
#6
Mary Ann Shinnick, Mary A Woo
BACKGROUND: There is a lack of objective and valid measures for assessing nursing clinical competence which could adversely impact patient safety. Therefore, we evaluated an objective assessment of clinical competence, Time to Task (ability to perform specific, critical nursing care activities within 5 min), and compared it to two subjective measures, (Lasater Clinical Judgement Rubric [LCJR] and common "pass/fail" assessment). DESIGN/METHODS: Using a prospective, "Known Groups" (Expert vs...
February 12, 2018: Nurse Education Today
https://www.readbyqxmd.com/read/29471146/the-impact-of-feedback-valence-and-communication-style-on-intrinsic-motivation-in-middle-childhood-experimental-evidence-and-generalization-across-individual-differences
#7
Elien Mabbe, Bart Soenens, Gert-Jan De Muynck, Maarten Vansteenkiste
Prior research among adolescents and emerging adults has provided evidence for the beneficial effects of positive (relative to negative) feedback and an autonomy-supportive (relative to a controlling) communication style on students' intrinsic motivation. Unfortunately, similar experimental research in middle childhood is lacking. Moreover, little attention has been paid to the question of whether individual differences in personality and perceived parenting play a role in these effects. In the current experimental study (N = 110; Mage  = 10...
February 19, 2018: Journal of Experimental Child Psychology
https://www.readbyqxmd.com/read/29471044/engineered-protein-degradation-of-farnesyl-pyrophosphate-synthase-is-an-effective-regulatory-mechanism-to-increase-monoterpene-production-in-saccharomyces-cerevisiae
#8
Bingyin Peng, Lars K Nielsen, Sotirios C Kampranis, Claudia E Vickers
Monoterpene production in Saccharomyces cerevisae requires the introduction of heterologous monoterpene synthases (MTSs). The endogenous farnesyl pyrosphosphate synthase (FPPS; Erg20p) competes with MTSs for the precursor geranyl pyrophosphate (GPP), which limits the production of monoterpenes. ERG20 is an essential gene that cannot be deleted and transcriptional down-regulation of ERG20 has failed to improve monoterpene production. Here, we investigated an N-degron-dependent protein degradation strategy to down-regulate Erg20p activity...
February 19, 2018: Metabolic Engineering
https://www.readbyqxmd.com/read/29470856/leishmania-donovani-inhibits-ferroportin-translation-by-modulating-fbxl5-irp2-axis-for-its-growth-within-host-macrophages
#9
Nupur Kanti Das, Sandhya Sandhya, G Vishnu Vivek, Rajiv Kumar, Amit Kumar Singh, Saswat Kumar Bal, Sanju Kumari, Chinmay K Mukhopadhyay
Hepcidin mediated ferroportin (Fpn) degradation in macrophages is a well adopted strategy to limit iron availability towards invading pathogens. Leishmania donovani (LD), a protozoan parasite, resides within macrophage and competes with host for availing iron. Using in vitro and in vivo model of infection we reveal that LD decreases Fpn abundance in host macrophages by hepcidin independent mechanism. Unaffected level of Fpn-FLAG in LD infected J774 macrophage confirms that Fpn down-regulation is not due its degradation...
February 22, 2018: Cellular Microbiology
https://www.readbyqxmd.com/read/29470696/additive-hazards-model-with-auxiliary-subgroup-survival-information
#10
Jie He, Hui Li, Shumei Zhang, Xiaogang Duan
The semiparametric additive hazards model is an important way for studying the effect of potential risk factors for right-censored time-to-event data. In this paper, we study the additive hazards model in the presence of auxiliary subgroup [Formula: see text]-year survival information. We formulate the known auxiliary information in the form of estimating equations, and combine them with the conventional score-type estimating equations for the estimation of the regression parameters based on the maximum empirical likelihood method...
February 22, 2018: Lifetime Data Analysis
https://www.readbyqxmd.com/read/29470477/m%C3%A4-ori-indigenous-health-framework-in-action-addressing-ethnic-disparities-in-healthcare
#11
Ibrahim S Al-Busaidi, Tania Huria, Suzanne Pitama, Cameron Lacey
There has been a steady increase in cultural competency training in medical education programmes worldwide. To provide high-quality culturally competent care and reduce health disparities between Māori and non-Māori in New Zealand, several health models have been devised. The Indigenous Health Framework (IHF), currently taught at the University of Otago, Christchurch undergraduate medical programme, is a tool developed to assist health professionals to broaden their range of clinical assessment and communicate effectively with Māori patients and whānau, thereby improving health outcomes and reducing disparities...
February 23, 2018: New Zealand Medical Journal
https://www.readbyqxmd.com/read/29470468/an-audit-of-risk-assessments-for-suicide-and-attempted-suicide-in-ed-a-retrospective-review-of-quality
#12
Wayne de Beer, Bernard DeWitt, Jules Schofield, Helen Clark, Veronique Gibbons
AIM: The primary aim of this audit was to determine the quality of psychiatric risk assessments conducted by Mental Health & Addiction Services clinicians for patients presenting to the emergency department, Waikato Hospital, Hamilton, New Zealand following an attempted suicide. METHOD: A retrospective, randomised audit of 376 files of patients who had presented to the ED over a 12-month period from 1 July 2015 to 30 June 2016 was conducted, following the standards outlined in the present New Zealand Ministry of Health Clinical Practice Guideline for Deliberate Self Harm (DSH)...
February 23, 2018: New Zealand Medical Journal
https://www.readbyqxmd.com/read/29470464/generation-of-human-brain-region-specific-organoids-using-a-miniaturized-spinning-bioreactor
#13
Xuyu Qian, Fadi Jacob, Mingxi Max Song, Ha Nam Nguyen, Hongjun Song, Guo-Li Ming
Human brain organoids, 3D self-assembled neural tissues derived from pluripotent stem cells, are important tools for studying human brain development and related disorders. Suspension cultures maintained by spinning bioreactors allow for the growth of large organoids despite the lack of vasculature, but commercially available spinning bioreactors are bulky in size and have low throughput. Here, we describe the procedures for building the miniaturized multiwell spinning bioreactor SpinΩ from 3D-printed parts and commercially available hardware...
March 2018: Nature Protocols
https://www.readbyqxmd.com/read/29470218/expanding-rn-scope-of-practice-to-include-lumbar-puncture
#14
Jennifer Ernst, Christine D Aliory, Catherine R Yows
: The competing demands of caring for high-acuity patients, reducing health care costs, and improving access to specialty care are complex challenges facing all health care providers. One approach-empowering nurses to expand their scope of practice-has been successfully employed for two decades by the nurse and physician leadership of a neurology department in an urban academic medical center. This article discusses the department's implementation of a quality improvement initiative to enhance access to neurology services in an ambulatory clinic by extending nursing practice to include lumbar puncture...
March 2018: American Journal of Nursing
https://www.readbyqxmd.com/read/29470073/molecular-hydrogen-yields-from-the-%C3%AE-self-radiolysis-of-nitric-acid-solutions-containing-plutonium-or-americium
#15
Colin R Gregson, Gregory P Horne, Robin M Orr, Simon M Pimblott, Howard E Sims, Robin J Taylor, Kevin J Webb
The yield of molecular hydrogen, as a function of nitric acid concentration, from the α-radiolysis of aerated nitric acid and its mixtures with sulfuric acid containing plutonium or americium has been investigated. Comparison of experimental measurements with predictions of a Monte Carlo radiation track chemistry model shows that, in addition to scavenging of the hydrated electron, its precursor, and the hydrogen atom, the quenching of excited state water is important in controlling the yield of molecular hydrogen...
February 22, 2018: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/29469819/the-long-noncoding-rna-hotair-in-breast-cancer-does-autophagy-play-a-role
#16
Elżbieta Pawłowska, Joanna Szczepanska, Janusz Blasiak
HOTAIR (HOX transcript antisense RNA) plays a critical role in chromatin dynamics through the interaction with histone modifiers resulting in transcriptional gene silencing. The promoter of the HOTAIR gene contains multiple estrogen response elements (EREs) and is transcriptionally activated by estradiol in estrogen receptor-positive breast cancer cells. HOTAIR competes with BRCA1, a critical protein in breast cancer and is a critical regulator of genes involved in epithelial-to-mesenchymal transition. It mediates an oncogenic action of c-Myc, essential for breast carcinogenesis...
November 3, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29469818/multi-band-magnetotransport-in-exfoliated-thin-films-of-cu-sub-x-sub-bi-sub-2-sub-se-sub-3-sub
#17
Jack Allen Alexander-Webber, Jian Huang, James Beilsten-Edmands, Patrik Čermák, Cestmir Drasar, R J Nicholas, A I Coldea
We report magnetotransport studies in thin (<100nm) exfoliated films of Cu<sub>x</sub>Bi<sub>2</sub>Se<sub>3</sub> and we detect an unusual electronic transition at low temperatures. Bulk crystals show weak superconductivity with T<sub>c</sub>∽3.5K and a possible electronic phase transition around 200K. Following exfoliation, superconductivity is supressed and a strongly temperature dependent multi-band conductivity is observed for T<30K...
February 22, 2018: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/29469647/how-skilled-do-israeli-nurses-perceive-themselves-to-be-in-providing-palliative-care-results-of-a-national-survey
#18
Shelli L Feder, David Collett, Samantha Conley, Dena Schulman-Green, Tikva Meron, Nathan Cherny
BACKGROUND: In Israel, palliative care (PC) services are limited. This study assessed Israeli nurses' perceived competencies and educational needs in providing PC. DESIGN: Online administration of the End-of-Life Professional Caregiver Survey (EPCS). SETTING/SUBJECTS: Oncology and PC nurses were identified through the Israel Ministry of Health and Oncology Nurses' Society. MEASUREMENTS: Demographic and practice data were analysed using analysis of variance tests to determine differences between nurse characteristics by EPCS domains...
February 2, 2018: International Journal of Palliative Nursing
https://www.readbyqxmd.com/read/29468799/a-consensus-model-shifting-assessment-practices-in-dietetics-tertiary-education
#19
Rachel Bacon, Jane Kellett, Janeane Dart, Cathy Knight-Agarwal, Rebecca Mete, Susan Ash, Claire Palermo
AIM: The aim of this research was to evaluate a Consensus Model for competency-based assessment. METHODS: An evaluative case study was used to allow a holistic examination of a constructivist-interpretivist programmatic model of assessment. Using a modified Delphi process, the competence of all 29 students enrolled in their final year of a Master of Nutrition and Dietetics course was assessed by a panel (with expertise in competency-based assessment; industry and academic representation) from a course e-portfolio (that included the judgements of student performance made by worksite educators) and a panel interview...
February 21, 2018: Nutrition & Dietetics: the Journal of the Dietitians Association of Australia
https://www.readbyqxmd.com/read/29468777/caring-for-crying-babies-a-mixed-methods-study-to-understand-factors-influencing-nurses-and-doctors-management-of-infant-colic
#20
James McGann, Jaqueline Manohar, Harriet Hiscock, Denise O'Connor, Jan Hodgson, Franz Babl, Valerie Sung
AIM: The aim of this study was to determine the barriers and enablers influencing the uptake of two recommendations from a tertiary paediatric hospital's clinical practice guidelines by maternal and child health nurses (MCHNs) and emergency department (ED) doctors: (i) explaining normal crying; and (ii) avoiding attributing crying to gastro-oesophageal reflux (GOR) and limiting anti-reflux medication use. METHODS: The study was designed as 1-h focus group discussions, guided by the Theoretical Domains Framework, and a short questionnaire, with a purposive sample of MCHNs and ED doctors in Victoria, Australia in (March to September) 2015...
February 22, 2018: Journal of Paediatrics and Child Health
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