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https://www.readbyqxmd.com/read/28449448/analyzing-competing-risks-in-the-treatment-of-lung-cancer-a-good-start
#1
EDITORIAL
Jae Y Kim
No abstract text is available yet for this article.
March 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28449406/a-water-stable-dual-channel-luminescence-sensor-for-uo22-ion-based-on-an-anionic-terbium-iii-metal-organic-framework
#2
Junwei Ye, Raji Feyisa Bogale, Yangwei Shi, Yanzhen Chen, Xigang Liu, Yaoyao Yang, Siqi Zhang, Jianzhang Zhao, Guiling Ning
A stable 3D Tb(III)-based metal-organic framework [Tb(BPDC)2]*(CH3)2NH2 (DUT-101) was synthesized, and it is the first efficient dual-channel luminescence sensor for aqueous UO22+ ion. DUT-101 possesses an anionic three-dimensional framework and protonated dimethylamine molecules embedded within the channels. Intense green emission of DUT-101 could be highly selectively and sensitively quenched by UO22+ ions even in the coexistence of other competing metal ions. The possible sensing mechanism was proposed as well based on both suppression of luminescence resonance energy transfer and enhancement of intermolecular electronic transfer...
April 27, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28449317/a-comparison-of-individual-based-genetic-distance-metrics-for-landscape-genetics
#3
A J Shirk, E L Landguth, S A Cushman
A major aim of landscape genetics is to understand how landscapes resist gene flow and thereby influence population genetic structure. An empirical understanding of this process provides a wealth of information that can be used to guide conservation and management of species in fragmented landscapes, and also to predict how landscape change may affect population viability. Statistical approaches to infer the true model among competing alternatives are based on the strength of the relationship between pairwise genetic distances and landscape distances among sampled individuals in a population...
April 27, 2017: Molecular Ecology Resources
https://www.readbyqxmd.com/read/28449302/prescribing-safety-assessment-2016-delivery-of-a-national-prescribing-assessment-to-7-343-uk-final-year-medical-students
#4
Simon R J Maxwell, Jamie J Coleman, Lynne Bollington, Celia Taylor, David J Webb
AIM(S): Newly graduated doctors write a large proportion of prescriptions in UK hospitals but recent studies have shown that they frequently make prescribing errors. The Prescribing Safety Assessment (PSA) has been developed as an assessment of competence in relation to prescribing and supervising the use of medicines. This report describes the delivery of the PSA to all UK final-year medical students in 2016 (PSA2016). METHODS: The PSA is a 2-hour online assessment comprising eight sections which cover various aspects of prescribing defined within the outcomes of undergraduate education identified by the UK General Medical Council...
April 27, 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28449293/a-novel-approach-to-study-medical-decision-making-in-the-clinical-setting-the-own-point-of-view-perspective
#5
Thierry Pelaccia, Jacques Tardif, Emmanuel Triby, Bernard Charlin
BACKGROUND: Making diagnostic and therapeutic decisions is a critical activity among physicians. It relies on the ability of physicians to use cognitive processes and specific knowledge in the context of a clinical reasoning. This ability is a core competency in physicians, especially in the field of emergency medicine where the rate of diagnostic errors is high. Studies that explore medical decision-making in an authentic setting are increasing significantly. They are based on the use of qualitative methods which are applied at two separate times: 1) a video recording of the subject's actual activity in an authentic setting and 2) an interview with the subject, supported by the video recording...
April 27, 2017: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/28449275/public-perception-of-dermatology-and-dermatologists-in-italy-results-from-a-population-based-national-survey
#6
P Gisondi, G Deangelis, G Venturelli, G Girolomoni
INTRODUCTION: The public perception of Dermatology and dermatologists may be very relevant in guiding strategies for improving dermatologic care but it has been poorly investigated in Europe. OBJECTIVE: To investigate the public's perception of Dermatology and dermatologists in Italy. METHODS: A representative sampling of Italian adults (n=1500, aged 18-70 years), residing throughout the national territory was interviewed through a population-based telephone survey using a structured questionnaire...
April 27, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28449261/exploring-uncertainty-of-amazon-dieback-in-a-perturbed-parameter-earth-system-ensemble
#7
Chris A Boulton, Ben B B Booth, Peter Good
The future of the Amazon rainforest is unknown due to uncertainties in projected climate change and the response of the forest to this change (forest resiliency). Here we explore the effect of some uncertainties in climate and land surface processes on the future of the forest, using a perturbed physics ensemble of HadCM3C. This is the first time Amazon forest changes are presented using an ensemble exploring both land vegetation processes and physical climate feedbacks in a fully coupled modelling framework...
April 27, 2017: Global Change Biology
https://www.readbyqxmd.com/read/28449084/perceived-quality-of-life-following-elder-mistreatment-in-rural-india
#8
Srinivasan Chokkanathan, Aravindhan Natarajan
Objectives: Using resilience theory, we examined multiple risks (individual, familial, and mistreatment characteristics) and promotive factors (mastery and social support) associated with perceived quality of life following mistreatment and tested two competing models, compensatory and protective models, to explain the role of promotive factors in the mistreatment-wellbeing linkage. Method: Face-to-face interviews were conducted by administering standardized instruments to 897 randomly selected older adults in rural Tamil Nadu, India...
April 26, 2017: Journals of Gerontology. Series B, Psychological Sciences and Social Sciences
https://www.readbyqxmd.com/read/28448905/drug-use-generations-and-patterns-of-injection-drug-use-birth-cohort-differences-among-people-who-inject-drugs-in-los-angeles-and-san-francisco-california
#9
Ricky N Bluthenthal, Lynn Wenger, Daniel Chu, Philippe Bourgois, Alex H Kral
OBJECTIVES: A robust literature documents generational trends in drug use. We examined the implications of changing national drug use patterns on drug injection histories of diverse people who inject drugs (PWID). METHODS: Drug use histories were collected from 776 active PWID in 2011-13. Using descriptive statistics, we examine drug use initiation by year and birth cohort (BC) differences in drug first injected. A multivariate linear regression model of time to injection initiation ([TTII] (year of first injection minus year of first illicit drug use) was developed to explore BC differences...
April 19, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28448436/role-of-archaeal-hera-protein-in-the-biology-of-the-bacterium-thermus-thermophilus
#10
Alba Blesa, Nieves G Quintans, Ignacio Baquedano, Carlos P Mata, José R Castón, José Berenguer
Intense gene flux between prokaryotes result in high percentage of archaeal genes in the genome of the thermophilic bacteria Thermus spp. Among these archaeal genes a homolog to the Sulfolobus spp. HerA protein appears in all of the Thermus spp. strains so far sequenced (HepA). The role of HepA in Thermus thermophilus HB27 has been analyzed using deletion mutants, and its structure resolved at low resolution by electron microscopy. Recombinant HepA shows DNA-dependent ATPase activity and its structure revealed a double ring, conically-shaped hexamer with an upper diameter of 150 Å and a bottom module of 95 Å...
April 27, 2017: Genes
https://www.readbyqxmd.com/read/28448307/explaining-performance-in-health-care-how-and-when-top-management-competencies-make-the-difference
#11
Milena Vainieri, Francesca Ferrè, Giorgio Giacomelli, Sabina Nuti
BACKGROUND: One of the most distinctive management competencies is related to the ability to structure the strategic vision, develop long-term plans, and communicate them efficiently to the employees in order to empower them to enact. These managerial competencies in complex organizations are strongly related to the capacity to engage professionals as a predictor of high-performing organizations. PURPOSE: The aim of this study was to investigate the relationship between top management competencies, information sharing, and organizational performance in public health care system and to look at the management role in assuring information sharing on organizational strategies to achieve professionals' engagement...
April 26, 2017: Health Care Management Review
https://www.readbyqxmd.com/read/28448302/qsen-institute-rn-bsn-task-force-white-paper-on-recommendation-for-systems-based-practice-competency
#12
Ann M Stalter, Janet M Phillips, Mary A Dolansky
The Quality and Safety Education for Nurses (QSEN) Institute RN-BSN Task Force presents a white paper on Recommendation for a Systems-based Practice Competency. The task force proposes a seventh QSEN competency, systems-based practice, to improve patient quality and safety. Recommendations to integrate systems-based practice into both education and practice settings, consistent with job descriptions and promotion criteria, involve a comprehensive continuing education program for nurses upon interview, orientation, residency programming, performance evaluation, and license renewal...
April 26, 2017: Journal of Nursing Care Quality
https://www.readbyqxmd.com/read/28448300/assessment-of-the-quality-of-nursing-care-from-perspectives-of-nurses-who-experienced-hospitalization-as-patients
#13
Rana M Elayan, Muayyad M Ahmad
Nurses as patients or caregivers evaluated their care differently than nonnurses. A qualitative design with content analysis was used to provide an assessment of the quality of nursing care by examining nurses' perceptions as recipients of care. The 231 participants were registered nurses recruited from 8 hospitals in Amman, Jordan. Participants evaluated the quality of nursing care as either high (29.5%) or low (70.5%). Four improvement themes emerged: improving competency, serve with caring, professionalism, and administrative factors...
April 26, 2017: Journal of Nursing Care Quality
https://www.readbyqxmd.com/read/28448162/joblessness-and-lost-earnings-after-ards-in-a-1-year-national-multicenter-study
#14
Biren B Kamdar, Minxuan Huang, Victor D Dinglas, Elizabeth Colantuoni, Till M von Wachter, Ramona O Hopkins, Dale M Needham
RATIONALE: Following acute respiratory distress syndrome (ARDS), joblessness is common, but poorly understood. OBJECTIVES: To evaluate the timing of return to work following ARDS, and associated risk factors, lost earnings, and changes in healthcare coverage Methods: Over 12-month longitudinal follow-up, ARDS survivors from 43 U.S. ARDSNet hospitals provided employment and healthcare coverage data via structured telephone interviews. Factors associated with the timing of return to work were assessed using Fine and Gray regression analysis...
April 27, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28448128/total-chemical-synthesis-and-folding-of-all-l-and-all-d-variants-of-oncogenic-kras-g12v
#15
Adam Marc Levinson, John H McGee, Andrew G Roberts, Gardner Creech, Ting Wang, Michael T Peterson, Ronald C Hendrickson, Gregory L Verdine, Samuel J Danishefsky
The Ras proteins are essential GTPases involved in the regulation of cell proliferation and survival. Mutated oncogenic forms of Ras alter effector binding and innate GTPase activity, leading to deregulation of downstream signal transduction. Mutated forms of Ras are involved in approximately 30% of human cancers. Despite decades of effort to develop direct Ras inhibitors, Ras has long been considered 'undruggable' due to its high affinity for GTP and its lack of hydrophobic binding pockets. Herein, we report a total chemical synthesis of all-L- and all-D-amino acid biotinylated variants of oncogenic mutant KRas(G12V)...
April 27, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28448121/hiv-1-frameshift-rna-targeted-triazoles-inhibit-propagation-of-replication-competent-and-multi-drug-resistant-hiv-in-human-cells
#16
Thomas A Hilimire, Jeffrey M Chamberlain, Viktoriya Anokhina, Ryan P Bennett, Oliver Swart, Jason R Myers, John M Ashton, Ryan A Stewart, Aaron L Featherston, Kathleen Gates, Eric D Helms, Harold C Smith, Stephen Dewhurst, Benjamin L Miller
The HIV-1 frameshift-stimulating (FSS) RNA, a regulatory RNA of critical importance in the virus' life cycle, has been posited as a novel target for anti-HIV drug development. We report the synthesis and evaluation of triazole-containing compounds able to bind the FSS with high affinity and selectivity. Readily accessible synthetically, these compounds are less toxic than previously reported olefin congeners. We show for the first time that FSS-targeting compounds have antiviral activity against replication-competent HIV in human cells, including a highly cytopathic, multi-drug-resistant strain...
April 27, 2017: ACS Chemical Biology
https://www.readbyqxmd.com/read/28448041/mass-spectrometry-and-luminogenic-based-approaches-to-characterize-phase-i-metabolic-competency-of-in-vitro-cell-cultures
#17
Andrew Baxter, Emmanuel Minet
Xenobiotic metabolizing enzymes play a key function in the biotransformation of medicines and toxicants by adding functional groups that increase solubility and facilitate excretion. On some occasions those structural modifications lead to the formation of new toxic products. In order to reduce animal testing, chemical risk can be assessed using metabolically competent cells. The expression of metabolic enzymes, however, is not stable over time in many in vitro primary culture systems and is often partial or absent in cell lines...
March 28, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28447917/differences-in-experiences-of-discrimination-in-accessing-social-services-among-transgender-gender-nonconforming-individuals-by-dis-ability
#18
Shanna K Kattari, N Eugene Walls, Stephanie Rachel Speer
Transgender and gender nonconforming (GNC) individuals frequently experience discrimination and potentially a lack of respect from service providers, suggesting they have decreased access to professionals with cultural competency. Similarly, people with disabilities experience higher levels of discrimination in social services than their nondisabled counterparts. From an intersectional perspective, this study examines rates of discrimination in accessing social services faced by transgender and GNC people, comparing across ability...
April 2017: Journal of Social Work in Disability & Rehabilitation
https://www.readbyqxmd.com/read/28447717/knockdown-of-zfpl1-results-in-increased-autophagy-and-autophagy%C3%A2-related-cell-death-in-nci%C3%A2-n87-and-bgc%C3%A2-823-human-gastric-carcinoma-cell-lines
#19
Yong-Zheng Xie, Wan-Li Ma, Ji-Ming Meng, Xue-Qun Ren
Macroautophagy, which will hereafter be referred to as autophagy, is an evolutionarily conserved process, during which cells recycle and remove damaged organelles and proteins in response to cellular stress. However, the mechanisms underlying the regulation of autophagy remain to be fully elucidated. The present study demonstrated that knockdown of zinc finger protein like 1 (ZFPL1) induces autophagy and increases autophagic cell death in NCI‑N87 and BGC‑823 human gastric carcinoma cell lines. To examine the role of ZFPL1 in gastric carcinoma cells, ZFPL1 expression was downregulated by lentiviral infection...
March 9, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28447700/evolution-inspired-engineering-of-antibiotic-biosynthesis-enzymes
#20
M Metsä-Ketelä
Streptomyces soil bacteria are competent chemists that are able to produce thousands of chemically complex natural products. Key to the development of this rich source of metabolites appears to be an evolutionary pressure that promotes chemical diversity; new biosynthetic pathways are continuously being formed in these bacteria, which may result in the appearance of a novel bioactive compound that provides significant competitive advantage to the producing organism. In recent years, our work has focused on understanding how minor changes in the biosynthetic enzymes has led to drastically altered catalytic properties...
April 27, 2017: Organic & Biomolecular Chemistry
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