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https://www.readbyqxmd.com/read/29050308/the-lncrna-hoxa11-as-functions-as-a-competing-endogenous-rna-to-regulate-padi2-expression-by-sponging-mir-125a-5p-in-liver-metastasis-of-colorectal-cancer
#1
Dong Chen, Qiang Sun, Lufei Zhang, Xiaohu Zhou, Xiaofei Cheng, Dongkai Zhou, Feng Ye, Jianjiang Lin, Weilin Wang
Several long non-coding RNAs (lncRNAs) play important roles in the regulation of liver metastasis in colorectal cancer (CRC) patients. We previously described the potential involvement of HOMEOBOX A11 (HOXA11) antisense RNA (HOXA11-AS), miR-125a-5p, and peptidyl arginine deiminase 2 (PADI2) in promoting liver metastasis in CRC patients. In the present study, we verified the significant upregulation of HOXA11-AS and PADI2, as well as the downregulation of miR-125a-5p, in CRC patients with liver metastasis. Overexpression and knockdown studies of HOXA11-AS or PADI2, as well as gain-/loss-of-function studies of miR-125a-5p, revealed a positive correlation between HOXA11-AS and PADI2 and a negative correlation with miR-125a-5p in the regulation of liver metastasis in CRC cell lines...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29050268/long-non-coding-rna-neat1-regulates-epithelial-membrane-protein-2-expression-to-repress-nasopharyngeal-carcinoma-migration-and-irradiation-resistance-through-mir-101-3p-as-a-competing-endogenous-rna-mechanism
#2
Yujia Wang, Chunting Wang, Can Chen, Fengbo Wu, Pengfei Shen, Peng Zhang, Gu He, Xiang Li
The altered expression of long non-coding RNAs (lncRNAs) is often related to carcinogenesis, metastasis and resistance to radiation or chemotherapy. In the current study, cDNA microarray analysis found that NEAT1 expression was reduced in nasopharyngeal carcinoma (NPC) patients and that it regulated NPC progression. However, the detailed mechanisms of NEAT1 in NPC were unclear. NEAT1 repressed NPC cell growth, invasion and radiation resistance in vitro and tumor metastasis in vivo. In addition, the results of an approach integrating bioinformatics, luciferase reporter assays and RNA immunoprecipitation indicated that NEAT1 antagonized miR-101-3p through a competing endogenous RNA (ceRNA) mechanism and that the interaction between NEAT1 and EMP2 was miR-101-3p dependent...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29050058/-ambulant-anesthesia-limits-and-possibilities
#3
Harald Hofer, Frank Vescia
The number of operations carried out on an outpatient basis is increasing in Germany. This trend has been observed for years. The prerequisite is an infrastructure that is in line with guidelines. The competence of the anesthetist must not be restricted to that of a standard specialist anesthetist, but the physician should have experience in ambulatory anesthesia. Well-adjusted comorbidities of the patient are generally not a contraindication for an outpatient procedure. The heavily overweight patient can also be operated on an outpatient basis if he is compliant, comorbidities are well adjusted and intensive postoperative care is ensured...
October 2017: Anästhesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie: AINS
https://www.readbyqxmd.com/read/29049922/effect-of-co-culture-canine-cumulus-and-oviduct-cells-with-porcine-oocytes-during-maturation-and-subsequent-embryo-development-of-parthenotes-in%C3%A2-vitro
#4
Seok Hee Lee, Hyun Ju Oh, Min Jung Kim, Geon A Kim, Yoo Bin Choi, Young Kwang Jo, Erif Maha Nugraha Setyawan, Byeong Chun Lee
In the estrus stage, canine oocytes are surrounded by cumulus cells and undergo maturation in the oviduct for 2-3 days after ovulation. We hypothesized that canine oviduct cells (cOC) and canine cumulus cells (cCC) during this stage might affect the maturation of oocytes and thereby improve subsequent embryo development. Therefore, the objective of this study was to compare the effects of a cOC and cCC co-culture on oocyte in vitro maturation (IVM) and subsequent embryo development, and to analyze the gene expressions in a molecular fashion what co-culture actually gives the specific pathways in which the co-culture cells act to improve maturation and embryo development...
October 3, 2017: Theriogenology
https://www.readbyqxmd.com/read/29049919/comparison-of-cha2ds2-vasc-chads2-and-hatch-scores-for-the-prediction-of-new-onset-atrial-fibrillation-in-cancer-patients-a-nationwide-cohort-study-of-760-339-study-participants-with-competing-risk-analysis
#5
Wei-Syun Hu, Cheng-Li Lin
BACKGROUND AND AIMS: The current study was conducted to assess the ability of CHA2DS2-VASc, CHADS2 and HATCH scores in predicting new-onset atrial fibrillation (AF) among patients with cancer. METHODS: Patients with newly diagnosed cancer between 1 January, 2000 and 31 December, 2011, from the Registry for Catastrophic Illness Patient Database, were defined as the study cohort. CHA2DS2-VASc, CHADS2 and HATCH scores were used for new-onset AF prediction in these study patients, and the predictive accuracy of the scores was assessed by the receiver operating characteristics (ROC) curve...
October 7, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/29049917/response-to-culturally-competent-drug-treatment-among-homeless-persons-with-different-living-arrangements
#6
Erick G Guerrero, Ahyoung Song, Benjamin Henwood, Yinfei Kong, Tina Kim
This study investigated the association between program cultural competence and homeless individuals' drug use after treatment in Los Angeles County, California. Los Angeles County has the largest and most diverse population of homeless individuals in the nation. We randomly selected for analysis 52 drug-treatment programs and 2158 participants who identified as homeless in the Los Angeles County Participant Reporting System in 2011. We included their living arrangements (indoors and stable, indoors and unstable, and outdoors) and individual and program characteristics (particularly whether their programs used six culturally competent practices) in multilevel regression analyses...
October 12, 2017: Evaluation and Program Planning
https://www.readbyqxmd.com/read/29049814/cost-effectiveness-of-testing-and-treatment-for-latent-tuberculosis-infection-in-residents-born-outside-the-united-states-with-and-without-medical-comorbidities-in-a-simulation-model
#7
Abriana Tasillo, Joshua A Salomon, Thomas A Trikalinos, C Robert Horsburgh, Suzanne M Marks, Benjamin P Linas
Importance: Testing for and treating latent tuberculosis infection (LTBI) is among the main strategies to achieve TB elimination in the United States. The best approach to testing among non-US born residents, particularly those with comorbid conditions, is uncertain. Objective: To estimate health outcomes, costs, and cost-effectiveness of LTBI testing and treatment among non-US born residents with and without medical comorbidities. Design, Setting, and Participants: Decision analytic tree and Markov cohort simulation model among non-US born residents with no comorbidities, with diabetes, with HIV infection, or with end-stage renal disease (ESRD) using a health care sector perspective with 3% annual discounting...
October 16, 2017: JAMA Internal Medicine
https://www.readbyqxmd.com/read/29049793/triangular-resection-versus-neochordal-replacement-for-posterior-leaflet-prolapse-a-morphological-assessment
#8
Wenrui Ma, Jiafei Chen, Wei Zhang, Weihua Wu, Wei Ye, Wei Shi, Ye Kong
OBJECTIVES: To evaluate the morphological reconstruction as assessed by 3D transoesophageal echocardiography after triangular resection and neochordal replacement in the treatment of posterior leaflet prolapse. METHODS: We retrospectively selected 46 patients with isolated posterior leaflet prolapse who were undergoing mitral valve repair using triangular resection ( n  = 20) and neochordal replacement ( n  = 26) techniques. Sixty patients without valvular heart disease were also included as the control group...
August 14, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29049792/psychosocial-and-family-functioning-among-latino-youth-with-spina-bifida
#9
Jaclyn Lennon Papadakis, Laura Acevedo, Sonia Ramirez, Alexa Stern, Colleen F Driscoll, Grayson N Holmbeck
This study examined differences in psychosocial and family functioning between Latino and non-Latino Caucasian youth with spina bifida (SB), and examined family functioning as a predictor of youth psychosocial functioning as moderated by ethnicity. Participants were part of a larger, longitudinal study ( Devine, Holbein, Psihogios, Amaro, & Holmbeck, 2012 ) and included 74 non-Latino Caucasian youth with SB and 39 Latino youth with SB ( M age = 11.53, 52.2% female). Data were collected at Time 1 and 2 years later, and included questionnaire and observational data of psychosocial and family functioning...
July 17, 2017: Journal of Pediatric Psychology
https://www.readbyqxmd.com/read/29049603/enhancing-auditory-selective-attention-using-a-visually-guided-hearing-aid
#10
Gerald Kidd
Purpose: Listeners with hearing loss, as well as many listeners with clinically normal hearing, often experience great difficulty segregating talkers in a multiple-talker sound field and selectively attending to the desired "target" talker while ignoring the speech from unwanted "masker" talkers and other sources of sound. This listening situation forms the classic "cocktail party problem" described by Cherry (1953) that has received a great deal of study over the past few decades. In this article, a new approach to improving sound source segregation and enhancing auditory selective attention is described...
October 17, 2017: Journal of Speech, Language, and Hearing Research: JSLHR
https://www.readbyqxmd.com/read/29049602/speech-understanding-in-complex-listening-environments-by-listeners-fit-with-cochlear-implants
#11
Michael F Dorman, Rene H Gifford
Purpose: The aim of this article is to summarize recent published and unpublished research from our 2 laboratories on improving speech understanding in complex listening environments by listeners fit with cochlear implants (CIs). Method: CI listeners were tested in 2 listening environments. One was a simulation of a restaurant with multiple, diffuse noise sources, and the other was a cocktail party with 2 spatially separated point sources of competing speech. At issue was the value of the following sources of information, or interventions, on speech understanding: (a) visual information, (b) adaptive beamformer microphones and remote microphones, (c) bimodal fittings, that is, a CI and contralateral low-frequency acoustic hearing, (d) hearing preservation fittings, that is, a CI with preserved low-frequency acoustic in the same ear plus low-frequency acoustic hearing in the contralateral ear, and (e) bilateral CIs...
October 17, 2017: Journal of Speech, Language, and Hearing Research: JSLHR
https://www.readbyqxmd.com/read/29049601/age-related-changes-in-objective-and-subjective-speech-perception-in-complex-listening-environments
#12
Karen S Helfer, Gabrielle R Merchant, Peter A Wasiuk
Purpose: A frequent complaint by older adults is difficulty communicating in challenging acoustic environments. The purpose of this work was to review and summarize information about how speech perception in complex listening situations changes across the adult age range. Method: This article provides a review of age-related changes in speech understanding in complex listening environments and summarizes results from several studies conducted in our laboratory. Results: Both degree of high frequency hearing loss and cognitive test performance limit individuals' ability to understand speech in difficult listening situations as they age...
October 17, 2017: Journal of Speech, Language, and Hearing Research: JSLHR
https://www.readbyqxmd.com/read/29049600/speech-perception-in-complex-acoustic-environments-developmental-effects
#13
Lori J Leibold
Purpose: The ability to hear and understand speech in complex acoustic environments follows a prolonged time course of development. The purpose of this article is to provide a general overview of the literature describing age effects in susceptibility to auditory masking in the context of speech recognition, including a summary of findings related to the maturation of processes thought to facilitate segregation of target from competing speech. Method: Data from published and ongoing studies are discussed, with a focus on synthesizing results from studies that address age-related changes in the ability to perceive speech in the presence of a small number of competing talkers...
October 17, 2017: Journal of Speech, Language, and Hearing Research: JSLHR
https://www.readbyqxmd.com/read/29049599/auditory-scene-analysis-an-attention-perspective
#14
Elyse S Sussman
Purpose: This review article provides a new perspective on the role of attention in auditory scene analysis. Method: A framework for understanding how attention interacts with stimulus-driven processes to facilitate task goals is presented. Previously reported data obtained through behavioral and electrophysiological measures in adults with normal hearing are summarized to demonstrate attention effects on auditory perception-from passive processes that organize unattended input to attention effects that act at different levels of the system...
October 17, 2017: Journal of Speech, Language, and Hearing Research: JSLHR
https://www.readbyqxmd.com/read/29049598/cortical-and-sensory-causes-of-individual-differences-in-selective-attention-ability-among-listeners-with-normal-hearing-thresholds
#15
Barbara Shinn-Cunningham
Purpose: This review provides clinicians with an overview of recent findings relevant to understanding why listeners with normal hearing thresholds (NHTs) sometimes suffer from communication difficulties in noisy settings. Method: The results from neuroscience and psychoacoustics are reviewed. Results: In noisy settings, listeners focus their attention by engaging cortical brain networks to suppress unimportant sounds; they then can analyze and understand an important sound, such as speech, amidst competing sounds...
October 17, 2017: Journal of Speech, Language, and Hearing Research: JSLHR
https://www.readbyqxmd.com/read/29049549/transapical-cardioscopic-mitral-annuloplasty-a-short-term-survival-study-in-a-porcine-model
#16
Thang Duc Vu, Min Zin Oo, Duc-Viet Nguyen, Ervin Marquez Ocampo, Yilin Ong, Suganya Cheyyatraivendran-Arularasu, Lian-Kah Ti, Mark A Richards, Theo Kofidis
OBJECTIVES: The transapical approach provides concurrent surgical access to the mitral and the aortic valves, the root of the aorta and the left atrium. We previously showed the feasibility of transapical cardioscopic (TAC) surgery in a non-survival porcine model. However, reproducibility and feasibility of ring implantation using TAC have not been reported. Therefore, in this study, we hypothesized that implantation of a mitral annuloplasty ring can be feasibly and safely carried out endoscopically via the apex of the heart...
August 30, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29049532/pulmonary-valve-restitution-following-transannular-patch-repair-of-tetralogy-of-fallot
#17
Khushboo N Parikh, Nishant C Shah, Joseph B Clark, John L Myers
Chronic pulmonary insufficiency following transannular patch repair of tetralogy of Fallot may mandate restoration of a competent pulmonary valve. Pulmonary valve leaflets that are preserved at initial surgery may grow and develop normal morphology and subsequent valve repair may be possible. We reviewed our experience with native pulmonary valve restitution following transannular patch repair (2001-15). The cohort included 9 patients with a median age of 18.7 (range 10.6-31.3) years. Operative technique involved reapproximation of the anterior commissure of the pulmonary valve...
June 26, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29049381/a-structural-equation-model-of-the-relationship-between-insomnia-negative-affect-and-paranoid-thinking
#18
Alexander J Scott, Georgina Rowse, Thomas L Webb
BACKGROUND: A growing body of evidence points to relationships between insomnia, negative affect, and paranoid thinking. However, studies are needed to examine (i) whether negative affect mediates the relation between insomnia and paranoid thinking, (ii) whether different types of insomnia exert different effects on paranoia, and (iii) to compare the impact of objective and self-reported sleeping difficulties. METHOD: Structural equation modelling was therefore used to test competing models of the relationships between self-reported insomnia, negative affect, and paranoia...
2017: PloS One
https://www.readbyqxmd.com/read/29049339/reliability-of-transcardiopulmonary-thermodilution-cardiac-output-measurement-in-experimental-aortic-valve-insufficiency
#19
Martin Petzoldt, Constantin J Trepte, Jan Ridder, Stefan Maisch, Philipp Klapsing, Jan F Kersten, Hans Peter Richter, Jens C Kubitz, Daniel A Reuter, Matthias S Goepfert
BACKGROUND: Monitoring cardiac output (CO) is important to optimize hemodynamic function in critically ill patients. The prevalence of aortic valve insufficiency (AI) is rising in the aging population. However, reliability of CO monitoring techniques in AI is unknown. The aim of this study was to investigate the impact of AI on accuracy, precision, and trending ability of transcardiopulmonary thermodilution-derived COTCPTD in comparison with pulmonary artery catheter thermodilution COPAC...
2017: PloS One
https://www.readbyqxmd.com/read/29049224/primary-stability-in-total-hip-replacement-a-biomechanical-investigation
#20
Paul Schmitz, Boyko Gueorguiev, Ivan Zderic, Christian Pfeifer, Michael Nerlich, Stephan Grechenig
BACKGROUND: In total hip replacement (THR), it is essential to achieve a primary stability to guarantee good long-term results. A novel locking screw hip (LSH)-stem, anchored to the medial cortex of the proximal femur by 5 monocortical locking screws, was developed to overcome the shortcomings of uncemented press-fit and cemented straight stems while simultaneously achieving primary stability. The aim of this study was to investigate the biomechanical competence of the LSH-stem in comparison to an uncemented press-fit stem...
October 2017: Medicine (Baltimore)
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