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https://www.readbyqxmd.com/read/29333846/-food-allergy-in-children-recommendations-for-diagnosis-and-treatment
#1
(no author information available yet)
Food allergy arises from a specific immune response induced by food exposure. It is the first cause of anaphylaxis in childhood. Its prevalence increased exponentially in western countries. The proteins most frequently involved in infants are cow's milk and hen's egg; and in adults, seafood. Peanuts have the same frequency in both groups. The clinical manifestations and methodology of study are directly related to the pathophysiology of the disease. Clinical history, skin prick test, patch test, and food oral challenge are essential to arrive at a correct diagnosis, that will avoid unnecessary exclusions or exposures that carry life risk...
February 1, 2018: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/29313295/radiation-preparation-of-l-arginine-acrylic-acid-hydrogel-matrix-patch-for-transdermal-delivery-of-propranolol-hcl-in-hypertensive-rats
#2
Rasha R Radwan, Heba A Mohamed, H E Ali, Ghada A Mahmoud
In the present study, L-arginine/acrylic acid (Arg/AAc) batch hydrogel was successfully prepared by gamma irradiation for transdermal delivery of propranolol HCl in hypertensive rats. The resulted system has been characterized by FTIR to confirm the hydrogel formation. The swelling behavior of the prepared hydrogels was investigated as a function of time and pH. The kinetics of swelling has been investigated. In vivo pharmacokinetics evaluation, skin irritation test, and histopathological studies were investigated...
January 8, 2018: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/29229531/eriodictyol-stimulates-insulin-secretion-through-camp-pka-signaling-pathway-in-mice-islets
#3
Abdul Hameed, Rahman M Hafizur, Nusrat Hussain, Sayed Ali Raza, Mujeeb-Ur-Rehman, Sajda Ashraf, Zaheer Ul-Haq, Faisal Khan, Ghulam Abbas, M Iqbal Choudhary
Eriodictyol, a flavonoid isolated from Lyonia ovalifolia, was found to be the most potent insulin secretagogue in our preliminary studies. Here, we explored mechanism(s) of insulin secretory activity of eriodictyol in vitro and in vivo. Mice islets and MIN6 cells were incubated in basal and stimulatory glucose containing eriodictyol with or without agonist/antagonist. Secreted insulin and cAMP contents were measured using ELISA kits. K+- and Ca2+-channels currents were recorded with patch-clamp technique. Oral glucose tolerance test and plasma insulin was evaluated in non-diabetic and diabetic rats...
December 8, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29184825/a-comparative-evaluation-of-diclofenac-sodium-transdermal-patch-oral-diclofenac-sodium-with-intramuscular-injections-of-diclofenac-sodium-in-patients-suffering-from-oral-pain-a-randomized-control-trial
#4
Nallan Csk Chaitanya, P Karunakar, Komali Garlapati, Mounika Yeladandi, Pallavi Bidari, Pratima Soni
Background: Newer drug delivery systems such as transdermal patches using pain relieving or modifying agents emerged as a mainstream treatment protocol for management of pain on the outpatient basis. The administration of diclofenac 100 mg in the transdermal patch in the patients having dental pain due to periapical/periodontal infections was evaluated. Materials and Methods: Ninety patients of either gender, between 18 and 80 years were divided into 3 groups (Group A - oral medication, Group B - transdermal patch, Group C - intramuscular group)...
July 2017: International Journal of Pharmaceutical Investigation
https://www.readbyqxmd.com/read/29176534/immune-retinopathy-associated-with-nivolumab-administration-for-metastatic-non-small-cell-lung-cancer
#5
Manisha Reddy, Judy J Chen, Ananda Kalevar, Ryan Terribilini, Anita Agarwal
PURPOSE: To present a novel case of immune retinopathy associated with nivolumab therapy for non-small cell lung cancer. METHODS: Retrospective chart review. RESULTS: A 64-year-old woman presented with photoreceptor injury evidenced by hypoautofluorescent and hyperautofluorescent patches on fundus autofluorescence, loss of the ellipsoid zone on optical coherence tomography, and dysfunction of the rods and cones on electroretinogram. She had a history of Stage IV lung adenocarcinoma, treated with nivolumab, a checkpoint inhibitor...
November 22, 2017: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/29159581/inhibition-of-salivary-secretion-by-tolterodine-transdermal-patch
#6
Ji-Yeong Byeon, Young-Hoon Kim, Se-Hyung Kim, Choong-Min Lee, Chang-Ik Choi, Jung-Woo Bae, Choon-Gon Jang, Seok-Yong Lee, Yun Jeong Lee
Tolterodine, a nonselective muscarinic antagonist available only as immediate release (IR) or extended release (ER) oral formulations, is used for the treatment of overactive bladder (OAB). This study aimed to compare the efficacy and extent of dry mouth adverse effects of tolterodine transdermal patch to the oral formulation. The two formulations have been examined through the muscarinic receptor binding tests conducted in bladder and salivary gland tissues and the salivary secretion tests conducted in rats...
November 20, 2017: Archives of Pharmacal Research
https://www.readbyqxmd.com/read/29139375/kitty-litter-dermatitis-from-bromo-2-nitropropane-1-3-diol
#7
John W Sullenbarger, Brooke Hensley, Jeffrey B Travers
70-year-old white man presented with a 6-week history of an acute pruritic eruption in the axillary vaults, inguinal folds, and central lumbar area. Due to the severity of the pruritus, the patient was evaluated in the emergency department. He was treated with intramuscular triamcinolone, oral fluconazole, clobetasol cream, and miconazole powder, which provided only minimal relief. The patient had presented with brightly erythematous patches in the axillary vaults and inguinal folds with numerous erythematous, scaly, coalescing papules and plaques agminated on the lumbar region (Figure)...
2017: Skinmed
https://www.readbyqxmd.com/read/29114901/allergic-contact-dermatitis-caused-by-calcipotriol
#8
Liesbeth Gilissen, Sara Huygens, An Goossens
BACKGROUND: Calcipotriol, a synthetic vitamin D analogue, is widely used for the topical treatment of psoriasis. It often causes irritant reactions, whereas allergic contact dermatitis has less commonly been reported. OBJECTIVES: To report on 6 patients (among them an 11-year-old child) who presented with eczematous lesions complicating pre-existing dermatitis, observed in our tertiary referral patch test clinic between 2004 and 2016. METHODS: Patch tests were performed with the commercial preparation used by the patients and/or its ingredients, including calcipotriol (2 or 10 µg/ml in isopropyl alcohol), according to ESCD patch test guidelines...
November 8, 2017: Contact Dermatitis
https://www.readbyqxmd.com/read/29097239/studies-on-the-environmental-fate-ecotoxicology-and-toxicology-of-2-methyl-1-3-propanediol
#9
REVIEW
J Fowles, C Lewis, E Rushton
2-methyl 1,3-propandiol (MPD) is a low molecular weight, colorless glycol used in polymer and coating applications. The log Kow of -0.6 suggests partitioning to aqueous phases with a low concern for possible bioaccumulation. MPD was found to be inherently biodegradable. Ecotoxicological results in several aquatic and terrestrial species found no significant hazard potential. MPD is rapidly absorbed via the oral and dermal routes, metabolized to 3-hydroxybutyrate, and excreted in urine with a half-life of 3...
October 28, 2017: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/29033834/tc299423-a-novel-agonist-for-nicotinic-acetylcholine-receptors
#10
Teagan R Wall, Brandon J Henderson, George Voren, Charles R Wageman, Purnima Deshpande, Bruce N Cohen, Sharon R Grady, Michael J Marks, Daniel Yohannes, Paul J Kenny, Merouane Bencherif, Henry A Lester
(E)-5-(Pyrimidin-5-yl)-1,2,3,4,7,8-hexahydroazocine (TC299423) is a novel agonist for nicotinic acetylcholine receptors (nAChRs). We examined its efficacy, affinity, and potency for α6β2(∗) (α6β2-containing), α4β2(∗), and α3β4(∗) nAChRs, using [(125)I]-epibatidine binding, whole-cell patch-clamp recordings, synaptosomal (86)Rb(+) efflux, [(3)H]-dopamine release, and [(3)H]-acetylcholine release. TC299423 displayed an EC50 of 30-60 nM for α6β2(∗) nAChRs in patch-clamp recordings and [(3)H]-dopamine release assays...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29031891/low-efficacy-of-atopy-patch-test-in-predicting-tolerance-development-in-non-ige-mediated-cow-s-milk-allergy
#11
T A Gonzaga, F A Alves, M F A Cheik, C P de Barros, E R M A Rezende, G R S Segundo
BACKGROUND: The food atopy patch (APT) test has been used in previous studies to help the diagnosis of non-IgE mediated food allergies (FA). The aim of this study was to evaluate the efficacy of different cow's milk APT preparations to predict oral tolerance in children with previous non-IgE-mediated cow's milk allergy (CMA) diagnosis. METHODS: Thirty-two patients non-IgE-mediated CMA diagnosed by oral food challenge (OFC) were enrolled to perform APT with three different cow's milk preparations (fresh, 2% in saline solution, 2% in petrolatum) and comparing with a new OFC after at least three months of diet exclusion...
October 11, 2017: Allergologia et Immunopathologia
https://www.readbyqxmd.com/read/29025664/preparation-and-characterization-of-gellan-gum-glucosamine-clioquinol-film-as-oral-cancer-treatment-patch
#12
Wanchi Tsai, Huifang Tsai, Yinuan Wong, Juiyen Hong, Shwujen Chang, Mingwei Lee
To administer cancer drugs with improved convenience to patients and to enhance the bioavailability of cancer drugs for oral cancer therapy, this study prepared gellan gum/glucosamine/clioquinol (GG/GS/CQ) film as the oral cancer treatment patch. GG/GS/CQ film fabricated through the EDC-mediated coupling reactions (GG/GS/CQ/EDC film). The film of the physicochemical properties and drug release kinetics were studied. The effectiveness of GG/GS/CQ/EDC film as oral cancer treatment patch were evaluated with the animal model...
January 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28956834/the-emerging-role-of-zinc-in-the-pathogenesis-of-multiple-sclerosis
#13
REVIEW
Bo Young Choi, Jong Won Jung, Sang Won Suh
Our lab has previously demonstrated that multiple sclerosis-induced spinal cord white matter damage and motor deficits are mediated by the pathological disruption of zinc homeostasis. Abnormal vesicular zinc release and intracellular zinc accumulation may mediate several steps in the pathophysiological processes of multiple sclerosis (MS), such as matrix metallopeptidase 9 (MMP-9) activation, blood-brain barrier (BBB) disruption, and subsequent immune cell infiltration from peripheral systems. Oral administration of a zinc chelator decreased BBB disruption, immune cell infiltration, and spinal white matter myelin destruction...
September 28, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28695565/dental-patch-testing-in-patients-with-undifferentiated-oral-lichen-planus
#14
Shevya M Tiwari, Kurt Gebauer, Agnieszka M Frydrych, Sally Burrows
BACKGROUND/OBJECTIVES: Distinguishing between oral lichen planus (LP) and lichenoid reactions to dental restorations can be impossible on clinical and histopathological grounds. Epicutaneous patch testing is an investigation that may guide patients and physicians in making timely and costly decisions to replace or cover existing dental restorations. This study aimed to assess the role of epicutaneous patch testing with a battery of dental allergens in patients with undifferentiated oral LP...
July 11, 2017: Australasian Journal of Dermatology
https://www.readbyqxmd.com/read/28682286/analgesic-efficacy-and-safety-of-transdermal-and-oral-diclofenac-in-postoperative-pain-management-following-dental-implant-placement
#15
S Raja Rajeswari, Triveni Gowda, Tarun Kumar, Dhoom S Mehta, Kanchan Arya
The aim of this study was to compare the efficacy and safety of transdermal and oral routes of diclofenac for postoperative pain management in patients undergoing dental implant placement. Twenty systemically healthy, partially edentulous patients who required dental implants bilaterally in the mandibular first molar region were included. While the patient was under local anesthesia, an implant was placed in the mandibular first molar region of one quadrant. After a minimum of 4 weeks, an implant was placed in the contralateral quadrant under local anesthesia...
July 2017: General Dentistry
https://www.readbyqxmd.com/read/28597911/digitizing-medicines-for-remote-capture-of-oral-medication-adherence-using-co-encapsulation
#16
Sara H Browne, Charles Peloquin, Frank Santillo, Richard Haubrich, Leticia Muttera, Kathleen Moser, George Savage, Constance Benson, Terrence Blaschke
High-resolution measurement of medication adherence is essential to personalized drug therapy . An FDA-cleared device, using an edible ingestion sensor (IS), external wearable patch and paired mobile device, can detect and record ingestion events. Oral medications must be combined with an IS to generate precise 'digitized-medication' ingestion records. We developed a GMP-protocol to repackage oral medications with the IS within certified Capsugel® capsules, termed co-encapsulation (CoE). A randomized bioequivalence study of CoE-IS-Rifamate (Isoniazid/Rifampin 150/300mg) versus native-Rifamate was conducted in 12 patients with active Mycobacterium Tuberculosis (MTB) and demonstrated bioequivalence using the population method ratio test (95% CI)...
June 9, 2017: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28554186/exposure-to-cadmium-impairs-sperm-functions-by-reducing-catsper-in-mice
#17
Hua-Feng Wang, Meng Chang, Ting-Ting Peng, Yi Yang, Na Li, Tao Luo, Yi-Min Cheng, Meng-Zhi Zhou, Xu-Hui Zeng, Li-Ping Zheng
BACKGROUND: Cadmium (Cd), a common environmental heavy metal and endocrine disruptor, is known to exert toxic effects on the testes. However, the mechanisms accounting for its toxicity in mature spermatozoa remain unclear. METHODS: Adult male C57BL/6 mice were orally administered with CdCl2 for 5 weeks at 3 mg·kg-1·day-1. Additionally, mouse spermatozoa were incubated in vitro with different doses of CdCl2 (0, 10, 50, 250 µM). Several sperm functions including the sperm motility, viability and acrosome reaction (AR) ratio were then examined...
2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28442928/the-efficacy-and-safety-of-s-flurbiprofen-plaster-in-the-treatment-of-knee-osteoarthritis-a-phase-ii-randomized-double-blind-placebo-controlled-dose-finding-study
#18
Ikuko Yataba, Noboru Otsuka, Isao Matsushita, Hideo Matsumoto, Yuichi Hoshino
BACKGROUND: Nonsteroidal anti-inflammatory drug (NSAID) patches are convenient for use and show much less gastrointestinal side effects than oral NSAIDs, whereas its percutaneous absorption is not sufficient for the expression of clinical efficacy at satisfactory level. S-flurbiprofen plaster (SFPP) has shown dramatic improvement in percutaneous absorption results from animal and clinical studies. In this study, the efficacy and safety of SFPP were compared with placebo in patients with knee osteoarthritis (OA) to determine its optimal dose...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28414672/a-strong-and-fortuitous-case-of-dyspnea
#19
R Hammer, M Sciaudone
CASE: A 48 year-old man with no past medical history was sent to our emergency department (ED); from a primary care clinic for hypertensive urgency of 200/130. The man reported an intermittent non-productive cough of approximately one year's duration and worsening dyspnea on exertion and orthopnea over the last month with lower extremity swelling. Of note, he emigrated from Honduras twenty years ago. Blood pressure normalized with administration of Lasix in the ED. Physical exam revealed rales in lung bases bilaterally, jugular venous distension, lower extremity pitting edema with serpiginous patches of erythema and excoriation, and a cardiac gallop...
March 2017: Journal of the Louisiana State Medical Society: Official Organ of the Louisiana State Medical Society
https://www.readbyqxmd.com/read/28407984/review-allergic-contact-stomatitis
#20
REVIEW
Liviu Feller, Neil Hamilton Wood, Razia Abdool Gafaar Khammissa, Johan Lemmer
Allergic contact stomatitis (ACS) is an oral mucosal immunoinflammatory disorder variably characterized clinically by erythematous plaques, vesiculation, ulceration, and/or hyperkeratosis and by pain, burning sensation, or itchiness. ACS is brought about by a T cell-mediated, delayed hypersensitivity immune reaction generated by a second or subsequent contact exposure of an allergen with the oral mucosa, in a genetically susceptible, sensitized subject. Lichenoid contact reaction is a variant of ACS brought about by direct contact with the oral mucosa of certain metals in dental restorations...
May 2017: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
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