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https://www.readbyqxmd.com/read/28297591/estrogen-replacement-improves-verbal-memory-and-executive-control-in-oligomenorrheic-amenorrheic-athletes-in-a-randomized-controlled-trial
#1
Charumathi Baskaran, Brooke Cunningham, Franziska Plessow, Vibha Singhal, Ryan Woolley, Kathryn E Ackerman, Meghan Slattery, Hang Lee, Elizabeth A Lawson, Kamryn Eddy, Madhusmita Misra
OBJECTIVE: Both estrogen and exercise may have cognition enhancing benefits; however, young oligomenorrheic/amenorrheic athletes (OA) with estrogen deficiency have not been evaluated for cognitive deficits. Our objective was to determine whether 6 months of estrogen replacement will impact cognitive domains in OA. We hypothesized that estrogen replacement would improve verbal memory and executive control in OA. METHODS: We performed cognitive assessments at baseline and after 6 months in 48 OA (14-25 years) randomized to estrogen (EST+) (oral 30 µg ethinyl estradiol [n = 16] or transdermal 100 µg 17-β-estradiol patch [n = 13]) or no estrogen (EST-) (n = 19) in an ongoing clinical trial...
March 14, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/28291073/contact-allergy-to-ingredients-of-toothpastes
#2
Anton de Groot
The literature on contact allergy to (ingredients of) toothpastes is critically reviewed. We have found 47 case reports, small case series (n = 2-5) and citations published between 1900 and 2016 describing more than 60 patients allergic to toothpastes, and in addition 3 larger case series and many descriptions of toothpaste allergy among selected groups of patients. Allergic reactions usually manifest as cheilitis with or without dermatitis around the mouth, less frequently by oral symptoms. Formerly, many reactions were caused by cinnamon derivatives; more recently, reported allergens are diverse...
March 2017: Dermatitis
https://www.readbyqxmd.com/read/28290980/allergic-stomatitis-from-orthodontic-adhesives
#3
Mark R Peterson, Priscilla H Wong, Scott D Dickson, Christopher A Coop
We report a case of a type IV hypersensitivity reaction causing oral stomatitis, presumed to be the result of common dental adhesives. The case was diagnosed using patch testing to the dental adhesives that were used in the patient. Both of the adhesives tested contained a form of acrylate that is being seen more frequently in the literature as a cause of type IV hypersensitivity reactions. Metals can cause allergic reactions; however, other contact items need to be considered as a cause of oral allergic reactions...
March 2017: Military Medicine
https://www.readbyqxmd.com/read/28284784/trends-in-provider-management-of-patients-with-food-protein-induced-enterocolitis-syndrome
#4
Matthew Greenhawt, J Andrew Bird, Anna H Nowak-Węgrzyn
BACKGROUND: Food protein-induced enterocolitis syndrome (FPIES) is a non-IgE-mediated food allergy. OBJECTIVE: To better understand provider-level variation in FPIES knowledge and management. METHODS: A 23-question online survey was administered to AAAAI members during the spring and summer of 2014. RESULTS: Among 470 respondents, 64% reported "full understanding" of FPIES diagnosis/management; 78.8% reported managing 1 or more patient with FPIES; and 80...
March 8, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/28284586/do-bedsider-family-planning-mobile-text-message-and-e-mail-reminders-increase-kept-appointments-and-contraceptive-coverage
#5
Heike Thiel de Bocanegra, Mary Bradsberry, Carrie Lewis, Fran Maguire
OBJECTIVE: To determine whether Bedsider text message and e-mail reminders increase family planning contraceptive continuation and appointment rates. MATERIAL AND METHODS: We trained staff at three high-volume Family Planning, Access, Care, and Treatment (Family PACT) clinics to enroll women through a special portal to receive text message or e-mail reminders for contraceptive refills and clinic appointments. Women were matched by contraceptive method, time frame of index visit, age group, and language preference to Family PACT clients at comparison sites that did not use the Bedsider program...
March 9, 2017: Women's Health Issues: Official Publication of the Jacobs Institute of Women's Health
https://www.readbyqxmd.com/read/28214382/allergic-contact-cheilitis-from-anethole-containing-toothpastes-a-practical-solution
#6
N Horst, J Leysen, T Mellaerts, J Lambert, O Aerts
In patients presenting with therapy-resistant cheilitis, especially when extending to the perioral skin, patch tests should be performed, even in longstanding cases(1-2) . A 55-year-old woman suffered from an oozing cheilitis for three months with erythema, edema and crusting of the lips and perioral skin (Fig. 1). An intra-oral burning sensation, loss of taste and a dry mouth were also present. Microbiological swabs and a blood analysis did not reveal any abnormalities, and the application of topical corticosteroids brought only temporary relief...
February 18, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28207004/patch-testing-for-adverse-drug-reactions
#7
Sahil Sekhon, Susan T Nedorost
Adverse drug reactions result in a substantial number of hospital admissions and inpatient events. Diagnosis usually is made with clinical judgment and circumstantiality without diagnostic testing. Furthermore, even in situations where diagnostic testing is performed, no safe gold standard tests exist. Oral rechallenge is currently the gold standard but carries the risk of recrudescence of severe allergic symptoms. Other tests include skin prick tests, the lymphocyte transformation test, immunohistochemistry, and patch testing...
January 2017: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/28128086/vesicular-contact-reaction-may-progress-into-erythema-multiforme
#8
Magdalena Czarnecka-Operacz, Dorota Jenerowicz, Joanna Szulczyńska-Gabor, Ewa Teresiak-Mikołajczak, Joanna Szyfter-Harris, Monika Bowszyc-Dmochowska
Dear Editor, Erythema multiforme is considered an acute skin condition, characterized by a self-limiting and sometimes recurrent course. It is regarded as a type IV hypersensitivity reaction associated with certain infections, medications, and other various triggers. Allergic contact dermatitis is in turn a delayed type of induced allergy as a result of cutaneous contact with a specific allergen to which the patient develops specific sensitivity. This type of cutaneous reaction is associated with inflammation manifesting with erythema, edema, and vesicles...
December 2016: Acta Dermatovenerologica Croatica: ADC
https://www.readbyqxmd.com/read/28112529/frequency-and-risk-factors-of-penicillin-and-amoxicillin-allergy-in-suspected-patients-with-drug-allergy
#9
Mohammad Reza Fazlollahi, Katayoon Bidad, Raheleh Shokouhi, Raheleh Dashti, Mohammad Nabavi, Masoud Movahedi, Mohammad Hasan Bemanian, Ali Reza Shafiei, Najmoddin Kalantari, Effat Sadat Farboud, Zahra Pourpak, Mostafa Moin
BACKGROUND: Unconfirmed beta-lactam allergy is a significant public health problem because of the limitations it imposes in drug selection. In this study, we aimed to evaluate patients referred for beta-lactam allergy to determine the frequency of confirmed beta-lactam allergy and identify some risk factors. METHODS: In a prospective cohort study, all referred patients to Immunology, Asthma and Allergy Research Institute in Tehran University of Medical Sciences (between 2007 - 2009) who suspected to have beta-lactam allergy were entered into this study based on having the inclusion criteria...
January 2017: Archives of Iranian Medicine
https://www.readbyqxmd.com/read/28108140/steroid-treatment-in-ocular-tuberculosis-a-double-edged-sword
#10
S Souissi, T David, L Beral
INTRODUCTION: We report the case of a Caribbean patient with an atypical presentation of bilateral tuberculous chorioretinopathy. PATIENT AND METHODS: A 57-year-old woman, with hypertension and non-insulin dependent diabetes, was referred to our center for a sudden loss of vision in the right eye to hand motions. Ophthalmic examination revealed only right papilledema. Brain magnetic resonance imaging was normal. Laboratory examination revealed no signs of inflammation...
February 2017: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/28061543/transdermal-granisetron-for-the-prevention-of-nausea-and-vomiting-following-moderately-or-highly-emetogenic-chemotherapy-in-chinese-patients-a-randomized-double-blind-phase-iii-study
#11
Liu-Qing Yang, Xin-Chen Sun, Shu-Kui Qin, Ying-Xia Chen, He-Long Zhang, Ying Cheng, Zhen-Dong Chen, Jian-Hua Shi, Qiong Wu, Yu-Xian Bai, Bao-Hui Han, Wei Liu, Xue-Nong Ouyang, Ji-Wei Liu, Zhi-Hui Zhang, Yong-Qiang Li, Jian-Ming Xu, Shi-Ying Yu
BACKGROUND: The granisetron transdermal delivery system (GTDS) has been demonstrated effectiveness in the control of chemotherapy-induced nausea and vomiting (CINV) in previous studies. This is the first phase III study to evaluate the efficacy and tolerability of GTDS in patients receiving moderately emetogenic chemotherapy (MEC) or highly emetogenic chemotherapy (HEC) in China. METHODS: A total of 313 patients were randomized into the GTDS group (one transdermal granisetron patch, 7 days) or the oral granisetron group (granisetron oral 2 mg/day, ≥2 days)...
December 2016: Chinese Clinical Oncology
https://www.readbyqxmd.com/read/28035659/is-there-a-role-of-food-additives-in-recurrent-aphthous-stomatitis-a-prospective-study-with-patch-testing
#12
Duygu Gülseren, Asli Hapa, Sibel Ersoy-Evans, Gonca Elçin, Ayşen Karaduman
BACKGROUND: Recurrent aphthous stomatitis (RAS) is a common disease of the oral mucosa with an unknown etiology. This study aimed to determine if food additives play a role in the etiology of RAS as well as to determine if patch testing can be used to detect which allergens cause RAS. METHODS: This prospective study included 24 patients with RAS and 22 healthy controls. All the participants underwent patch testing for 23 food additives. RESULTS: In total, 21 (87...
March 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/27979025/atopy-patch-test-in-children-with-atopic-dermatitis
#13
Nualanong Visitsunthorn, Sunsanee Chatpornvorarux, Punchama Pacharn, Orathai Jirapongsananuruk
BACKGROUND: Atopic dermatitis is frequently associated with food and/or aeroallergen allergy. OBJECTIVE: To evaluate atopy patch tests (APTs) and skin prick tests (SPTs) in children with atopic dermatitis, using allergen extracts from locally lyophilized foods (cow's milk, egg white, egg yolk, wheat, soy, and shrimp), Dermatophagoides pteronyssinus, Dermatophagoides farinae, and American cockroach. METHODS: This study was a prospective, self-controlled study in children with atopic dermatitis...
December 2016: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/27907019/the-effects-of-transdermally-delivered-oleanolic-acid-on-malaria-parasites-and-blood-glucose-homeostasis-in-p-berghei-infected-male-sprague-dawley-rats
#14
Happiness P Sibiya, Musa V Mabandla, Cephas T Musabayane
The present study investigated the effects of transdermally delivered oleanolic acid (OA) monotherapy and in combination with chloroquine (CHQ) on malaria parasites and glucose homeostasis of P. berghei-infected male Sprague-Dawley rats. Oral glucose test (OGT) responses to OA-pectin patch and CHQ-OA combination matrix patch were monitored in non-infected and infected rats. To evaluate the short-term effects of treatment, percentage parasitaemia, blood glucose, glycogen and plasma insulin were monitored in separate groups of animals treated with either OA-patch monotherapy or CHQ-OA combination pectin patch over a 21-days period...
2016: PloS One
https://www.readbyqxmd.com/read/27866687/glibenclamide-nanocrystals-in-a-biodegradable-chitosan-patch-for-transdermal-delivery-engineering-formulation-and-evaluation
#15
Hany S M Ali, Ahmed F Hanafy
Glibenclamide (GBD) nanocrystals (D50 = 429 nm) were engineered by applying combined precipitation and homogenization procedures. GBD crystallinity was maintained during the nanonization process as revealed by differential scanning calorimetry and X-ray analyses. Nanonized and micronized GBD were incorporated into chitosan solutions to fabricate transdermal delivery systems (TDDSs), nano- and micro-GBD, respectively. The fabricated TDDSs displayed satisfactory physicochemical characteristics without substantial aggregation of GBD nanocrystals during the casting and drying procedures...
January 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27828643/fixed-drug-eruption-by-etoricoxib-confirmed-by-patch-test
#16
Aline Soares de Sousa, José Carlos Cardoso, Miguel Pinto Gouveia, Ana Rita Gameiro, Vera Barreto Teixeira, Maria Gonçalo
Non-steroidal, anti-inflammatory drugs, followed by antibiotics, are the main causes of fixed drug eruption. They provoke one or several round erythematous or bullous lesions that recur in the same place after taking the causative medication. A positive patch test on residual, lesional skin can replace satisfactorily oral reintroduction. We describe the case of a 74-year-old woman with numerous, rounded, erythematous lesions on the trunk and recurrent blistering on the fifth right-hand finger, which developed a few hours after taking etoricoxib...
September 2016: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/27789914/glycerin-borax-treatment-of-exfoliative-cheilitis-induced-by-sodium-lauryl-sulfate-a-case-report
#17
Kobkan Thongprasom
This paper reports on the results of a case study of a 19-year-old female who presented to the Oral Medicine clinic with a chief complaint of scaly and peeling lips. The lesions had persisted on her lips for more than 7 years and were refractory to previous treatment. Her physician's diagnosis was contact dermatitis. We diagnosed this patient as having exfoliative cheilitis (EC). A patch test using the toothpaste containing sodium lauryl sulfate (SLS) was positive and the patient discontinued using it. Instead, she started using a toothpaste not containing SLS...
June 2016: Acta Stomatologica Croatica
https://www.readbyqxmd.com/read/27766282/induction-of-gut-regulatory-cd39-t-cells-by-teriflunomide-protects-against-eae
#18
Javier Ochoa-Repáraz, Sara L Colpitts, Christopher Kircher, Eli J Kasper, Kiel M Telesford, Sakhina Begum-Haque, Anudeep Pant, Lloyd H Kasper
OBJECTIVE: To determine whether as an orally delivered treatment, teriflunomide, an inhibitor of the mitochondrial enzyme dihydroorotate dehydrogenase approved to treat relapsing forms of multiple sclerosis, could affect gut-associated lymphoid tissue (GALT) immune responses functionally. METHODS: C57BL/6 mice were treated orally with teriflunomide and flow cytometric analysis of immune GALT cells performed ex vivo, and adoptive transfer experiments were used to test the protective effects of GALT regulatory T (Treg) cells...
December 2016: Neurology® Neuroimmunology & Neuroinflammation
https://www.readbyqxmd.com/read/27757206/efficacy-of-alum-for-treatment-of-recurrent-aphthous-stomatitis
#19
Nasrin Rafieian, Hamidreza Abdolsamadi, Aliakbar Moghadamnia, Mina Jazayeri, Mohammadali Seif-Rabiee, Mina Salmanzadeh, Shahrbanoo Radi
BACKGROUND: Recurrent aphthous stomatitis (RAS) is the most common painful ulcers of oral mucosal which can cause many sufferings. Treatment of RAS often includes administration of corticosteroids, analgesics and regulators of the immune system. However, considering the side effects of these medications, even their topical application must be done with caution. Alum is used in traditional medicine for treatment of oral ulcers without significant side effect. This study sought to assess the effect of topical application of alum on aphthous ulcers...
2016: Caspian Journal of Internal Medicine
https://www.readbyqxmd.com/read/27753687/old-dog-begging-for-new-tricks-current-practices-and-future-directions-in-the-diagnosis-of-delayed-antimicrobial-hypersensitivity
#20
Katherine C Konvinse, Elizabeth J Phillips, Katie D White, Jason A Trubiano
PURPOSE OF REVIEW: Antimicrobials are a leading cause of severe T cell-mediated adverse drug reactions (ADRs). The purpose of this review is to address the current understanding of antimicrobial cross-reactivity and the ready availability of and evidence for in-vitro, in-vivo, and ex-vivo diagnostics for T cell-mediated ADRs. RECENT FINDINGS: Recent literature has evaluated the efficacy of traditional antibiotic allergy management, including patch testing, skin prick testing, intradermal testing, and oral challenge...
December 2016: Current Opinion in Infectious Diseases
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