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https://www.readbyqxmd.com/read/28108140/steroid-treatment-in-ocular-tuberculosis-a-double-edged-sword
#1
S Souissi, T David, L Beral
INTRODUCTION: We report the case of a Caribbean patient with an atypical presentation of bilateral tuberculous chorioretinopathy. PATIENT AND METHODS: A 57-year-old woman, with hypertension and non-insulin dependent diabetes, was referred to our center for a sudden loss of vision in the right eye to hand motions. Ophthalmic examination revealed only right papilledema. Brain magnetic resonance imaging was normal. Laboratory examination revealed no signs of inflammation...
January 17, 2017: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/28061543/transdermal-granisetron-for-the-prevention-of-nausea-and-vomiting-following-moderately-or-highly-emetogenic-chemotherapy-in-chinese-patients-a-randomized-double-blind-phase-iii-study
#2
Liu-Qing Yang, Xin-Chen Sun, Shu-Kui Qin, Ying-Xia Chen, He-Long Zhang, Ying Cheng, Zhen-Dong Chen, Jian-Hua Shi, Qiong Wu, Yu-Xian Bai, Bao-Hui Han, Wei Liu, Xue-Nong Ouyang, Ji-Wei Liu, Zhi-Hui Zhang, Yong-Qiang Li, Jian-Ming Xu, Shi-Ying Yu
BACKGROUND: The granisetron transdermal delivery system (GTDS) has been demonstrated effectiveness in the control of chemotherapy-induced nausea and vomiting (CINV) in previous studies. This is the first phase III study to evaluate the efficacy and tolerability of GTDS in patients receiving moderately emetogenic chemotherapy (MEC) or highly emetogenic chemotherapy (HEC) in China. METHODS: A total of 313 patients were randomized into the GTDS group (one transdermal granisetron patch, 7 days) or the oral granisetron group (granisetron oral 2 mg/day, ≥2 days)...
December 2016: Chinese Clinical Oncology
https://www.readbyqxmd.com/read/28035659/is-there-a-role-of-food-additives-in-recurrent-aphthous-stomatitis-a-prospective-study-with-patch-testing
#3
Duygu Gülseren, Asli Hapa, Sibel Ersoy-Evans, Gonca Elçin, Ayşen Karaduman
BACKGROUND: Recurrent aphthous stomatitis (RAS) is a common disease of the oral mucosa with an unknown etiology. This study aimed to determine if food additives play a role in the etiology of RAS as well as to determine if patch testing can be used to detect which allergens cause RAS. METHODS: This prospective study included 24 patients with RAS and 22 healthy controls. All the participants underwent patch testing for 23 food additives. RESULTS: In total, 21 (87...
December 30, 2016: International Journal of Dermatology
https://www.readbyqxmd.com/read/27979025/atopy-patch-test-in-children-with-atopic-dermatitis
#4
Nualanong Visitsunthorn, Sunsanee Chatpornvorarux, Punchama Pacharn, Orathai Jirapongsananuruk
BACKGROUND: Atopic dermatitis is frequently associated with food and/or aeroallergen allergy. OBJECTIVE: To evaluate atopy patch tests (APTs) and skin prick tests (SPTs) in children with atopic dermatitis, using allergen extracts from locally lyophilized foods (cow's milk, egg white, egg yolk, wheat, soy, and shrimp), Dermatophagoides pteronyssinus, Dermatophagoides farinae, and American cockroach. METHODS: This study was a prospective, self-controlled study in children with atopic dermatitis...
December 2016: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/27907019/the-effects-of-transdermally-delivered-oleanolic-acid-on-malaria-parasites-and-blood-glucose-homeostasis-in-p-berghei-infected-male-sprague-dawley-rats
#5
Happiness P Sibiya, Musa V Mabandla, Cephas T Musabayane
The present study investigated the effects of transdermally delivered oleanolic acid (OA) monotherapy and in combination with chloroquine (CHQ) on malaria parasites and glucose homeostasis of P. berghei-infected male Sprague-Dawley rats. Oral glucose test (OGT) responses to OA-pectin patch and CHQ-OA combination matrix patch were monitored in non-infected and infected rats. To evaluate the short-term effects of treatment, percentage parasitaemia, blood glucose, glycogen and plasma insulin were monitored in separate groups of animals treated with either OA-patch monotherapy or CHQ-OA combination pectin patch over a 21-days period...
2016: PloS One
https://www.readbyqxmd.com/read/27866687/glibenclamide-nanocrystals-in-a-biodegradable-chitosan-patch-for-transdermal-delivery-engineering-formulation-and-evaluation
#6
Hany S M Ali, Ahmed F Hanafy
Glibenclamide (GBD) nanocrystals (D50 = 429 nm) were engineered by applying combined precipitation and homogenization procedures. GBD crystallinity was maintained during the nanonization process as revealed by differential scanning calorimetry and X-ray analyses. Nanonized and micronized GBD were incorporated into chitosan solutions to fabricate transdermal delivery systems (TDDSs), nano- and micro-GBD, respectively. The fabricated TDDSs displayed satisfactory physicochemical characteristics without substantial aggregation of GBD nanocrystals during the casting and drying procedures...
January 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27828643/fixed-drug-eruption-by-etoricoxib-confirmed-by-patch-test
#7
Aline Soares de Sousa, José Carlos Cardoso, Miguel Pinto Gouveia, Ana Rita Gameiro, Vera Barreto Teixeira, Maria Gonçalo
Non-steroidal, anti-inflammatory drugs, followed by antibiotics, are the main causes of fixed drug eruption. They provoke one or several round erythematous or bullous lesions that recur in the same place after taking the causative medication. A positive patch test on residual, lesional skin can replace satisfactorily oral reintroduction. We describe the case of a 74-year-old woman with numerous, rounded, erythematous lesions on the trunk and recurrent blistering on the fifth right-hand finger, which developed a few hours after taking etoricoxib...
September 2016: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/27789914/glycerin-borax-treatment-of-exfoliative-cheilitis-induced-by-sodium-lauryl-sulfate-a-case-report
#8
Kobkan Thongprasom
This paper reports on the results of a case study of a 19-year-old female who presented to the Oral Medicine clinic with a chief complaint of scaly and peeling lips. The lesions had persisted on her lips for more than 7 years and were refractory to previous treatment. Her physician's diagnosis was contact dermatitis. We diagnosed this patient as having exfoliative cheilitis (EC). A patch test using the toothpaste containing sodium lauryl sulfate (SLS) was positive and the patient discontinued using it. Instead, she started using a toothpaste not containing SLS...
June 2016: Acta Stomatologica Croatica
https://www.readbyqxmd.com/read/27766282/induction-of-gut-regulatory-cd39-t-cells-by-teriflunomide-protects-against-eae
#9
Javier Ochoa-Repáraz, Sara L Colpitts, Christopher Kircher, Eli J Kasper, Kiel M Telesford, Sakhina Begum-Haque, Anudeep Pant, Lloyd H Kasper
OBJECTIVE: To determine whether as an orally delivered treatment, teriflunomide, an inhibitor of the mitochondrial enzyme dihydroorotate dehydrogenase approved to treat relapsing forms of multiple sclerosis, could affect gut-associated lymphoid tissue (GALT) immune responses functionally. METHODS: C57BL/6 mice were treated orally with teriflunomide and flow cytometric analysis of immune GALT cells performed ex vivo, and adoptive transfer experiments were used to test the protective effects of GALT regulatory T (Treg) cells...
December 2016: Neurology® Neuroimmunology & Neuroinflammation
https://www.readbyqxmd.com/read/27757206/efficacy-of-alum-for-treatment-of-recurrent-aphthous-stomatitis
#10
Nasrin Rafieian, Hamidreza Abdolsamadi, Aliakbar Moghadamnia, Mina Jazayeri, Mohammadali Seif-Rabiee, Mina Salmanzadeh, Shahrbanoo Radi
BACKGROUND: Recurrent aphthous stomatitis (RAS) is the most common painful ulcers of oral mucosal which can cause many sufferings. Treatment of RAS often includes administration of corticosteroids, analgesics and regulators of the immune system. However, considering the side effects of these medications, even their topical application must be done with caution. Alum is used in traditional medicine for treatment of oral ulcers without significant side effect. This study sought to assess the effect of topical application of alum on aphthous ulcers...
2016: Caspian Journal of Internal Medicine
https://www.readbyqxmd.com/read/27753687/old-dog-begging-for-new-tricks-current-practices-and-future-directions-in-the-diagnosis-of-delayed-antimicrobial-hypersensitivity
#11
Katherine C Konvinse, Elizabeth J Phillips, Katie D White, Jason A Trubiano
PURPOSE OF REVIEW: Antimicrobials are a leading cause of severe T cell-mediated adverse drug reactions (ADRs). The purpose of this review is to address the current understanding of antimicrobial cross-reactivity and the ready availability of and evidence for in-vitro, in-vivo, and ex-vivo diagnostics for T cell-mediated ADRs. RECENT FINDINGS: Recent literature has evaluated the efficacy of traditional antibiotic allergy management, including patch testing, skin prick testing, intradermal testing, and oral challenge...
December 2016: Current Opinion in Infectious Diseases
https://www.readbyqxmd.com/read/27739370/systemic-allergy-to-corticosteroids-clinical-features-and-cross-reactivity
#12
Annick Barbaud, Julie Waton
Systemic hypersensitivity (HS) to corticosteroids (CS) is paradoxical but does exist. Some patients with a previous contact allergy to topical CS may develop a systemic contact dermatitis (SCD) while receiving CS orally or intravenously. However, a previous contact sensitization is not mandatory for developing a systemic HS to CS. Acute or delayed urticaria can occur in immediate HS. Immediate HS can be due to excipients, mainly carboxymethylcellulose or to CS themselves. Delayed reactions, mainly maculopapular rash and acute generalized exanthematous pustulosis can occur...
October 12, 2016: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/27665986/oral-leukoplakia-associated-with-amalgam-restorations
#13
Zeynep B Gönen, Canay Yılmaz Asan, Osman Etöz, Alper Alkan
The World Health Organization has defined oral leukoplakia (OL) as "a white patch or plaque of the oral mucosa that cannot be characterized clinically or pathologically as any other disease". A 21-year-old male with OL presented with a bilateral burning sensation in the buccal mucosa. The patient had amalgam restorations, and an epicutaneous patch test indicated a positive response to amalgam. The amalgam restorations were therefore removed and the cavities were refilled with a composite resin restorative material...
2016: Journal of Oral Science
https://www.readbyqxmd.com/read/27658557/allergic-contact-dermatitis-from-topical-acyclovir-case-series
#14
Anca Chiriac, Anca E Chiriac, Tudor Pinteala, Cosmin Moldovan, Simona Stolnicu
BACKGROUND: Despite the widespread use of oral or topical acyclovir, allergic contact dermatitis caused by it has been rarely reported, with fewer than 20 case studies published in the English literature to date. CASE REPORTS: A diagnosis of allergic contact dermatitis from acyclovir cream was established in a 62-year-old female patient who had been continuously using acyclovir cream for 3 weeks after systemic therapy for herpes zoster with acyclovir, and in a 35-year-old female patient, who had undergone liver transplantation in 2008 and subsequently developed a severe form of herpes zoster treated orally with 4 g/day acyclovir and prolonged topical administration of acyclovir cream...
September 19, 2016: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/27648197/pattern-and-outcome-of-acute-disseminated-encephalomyelitis-adem-in-children-experience-in-a-tertiary-center-upper-egypt
#15
Abdelrahim Abdrabou Sadek, Mostafa Ashry Mohamed, Ashraf Abou-Taleb, Marwa Ibrahim Mohammed
INTRODUCTION: Acute disseminated encephalomyelitis (ADEM) is an immune mediated disease of the brain. Although it occurs in all ages, most reported cases are in children and adolescents. The aims of this study were to study the clinical pattern and outcome of ADEM in children in a tertiary center in Upper Egypt and to determine the effect of combined use of steroids and IVIg on outcome. METHODS: This observational study was carried out from January 2014 through December 2014 in the Pediatric Department of Sohag University Hospital (Egypt)...
July 2016: Electronic Physician
https://www.readbyqxmd.com/read/27639640/absolute-bioavailability-and-safety-of-a-novel-rivastigmine-nasal-spray-in-healthy-elderly-individuals
#16
Timothy M Morgan, Bob Soh
AIMS: To test the feasibility of a novel rivastigmine nasal spray as prospective treatment for dementia. METHODS: A single dose, crossover absolute bioavailability and safety study was conducted with rivastigmine intravenous solution (1 mg) and nasal spray (3.126 mg) in eight healthy elderly individuals, aged 58-75 years. RESULTS: Absolute bioavailability (F) of the nasal spray was significant at 0.62 (0.15) for F > 0 (P < 0.001, n = 8)...
September 18, 2016: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/27634007/-clinical-characteristics-and-management-of-infants-less-than-1-year-old-suspected-with-allergy-to-cow-s-milk-protein
#17
Germán Errázuriz, Yalda Lucero, Sergio Ceresa, Mónica Gonzalez, Maureen Rossel, Andrés Vives
INTRODUCTION: Cow's milk protein allergy (CMPA) is highly prevalent in infants (2-5%). It has a wide clinical spectrum, and confirmation through an oral food challenge (OFC) is relevant for its differential diagnosis. Information on this topic is scarce in Chile. OBJECTIVE: To describe the demographic and clinical features of infants with suspected CMPA. PATIENTS AND METHOD: A retrospective study of patients<1 year-old, treated for suspected CMPA between 2009 and 2011...
November 2016: Revista Chilena de Pediatría
https://www.readbyqxmd.com/read/27587983/unmet-diagnostic-needs-in-contact-oral-mucosal-allergies
#18
REVIEW
Paola Lucia Minciullo, Giovanni Paolino, Maddalena Vacca, Sebastiano Gangemi, Eustachio Nettis
The oral mucosa including the lips is constantly exposed to several noxious stimuli, irritants and allergens. However, oral contact pathologies are not frequently seen because of the relative resistance of the oral mucosa to irritant agents and allergens due to anatomical and physiological factors. The spectrum of signs and symptoms of oral contact allergies (OCA) is broad and a large number of condition can be the clinical expression of OCA such as allergic contact stomatitis, allergic contact cheilitis, geographic tongue, oral lichenoid reactions, burning mouth syndrome...
2016: Clinical and Molecular Allergy: CMA
https://www.readbyqxmd.com/read/27587069/the-citirivad-study-citicoline-plus-rivastigmine-in-elderly-patients-affected-with-dementia-study
#19
Alberto Castagna, Antonino Maria Cotroneo, Giovanni Ruotolo, Pietro Gareri
BACKGROUND: Acetylcholinesterase inhibitors (AchEIs), such as rivastigmine, coadministered with cholinergic precursors, such as citicoline, could be effective in Alzheimer's disease (AD) and in mixed dementia (MD), because they are able to increase the intrasynaptic levels of acetylcholine more than the single drugs given alone. OBJECTIVE: The aim of the present study was to show the effectiveness of oral citicoline plus rivastigmine in patients with AD and MD. METHODS: The CITIRIVAD study was a retrospective case-control study on 174 consecutive outpatients aged ≥65 years, affected with AD or MD, mean age 81...
December 2016: Clinical Drug Investigation
https://www.readbyqxmd.com/read/27537762/clonidine-does-not-reduce-pain-or-opioid-consumption-after-noncardiac-surgery
#20
Alparslan Turan, Rovnat Babazade, Andrea Kurz, Phillip J Devereaux, Nicole M Zimmerman, Matthew T Hutcherson, Amanda J Naylor, Wael Ali Sakr Esa, Joel Parlow, Ian Gilron, Hooman Honar, Vafi Salmasi, Daniel I Sessler
BACKGROUND: Clonidine is an α2-adrenoceptor agonist, which has analgesic properties. However, the analgesic efficacy of perioperative clonidine remains unclear. We, therefore, tested the hypothesis that clonidine reduces both pain scores and cumulative opioid consumption during the initial 72 hours after noncardiac surgery. METHODS: Six hundred twenty-four patients undergoing elective noncardiac surgery under general and spinal anesthesia were included in this substudy of the PeriOperative ISchemia Evaluation-2 trial...
September 2016: Anesthesia and Analgesia
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