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Psoriasis and adipokines

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https://www.readbyqxmd.com/read/29235656/nonalcoholic-fatty-liver-disease-in-patients-with-psoriasis-a-consequence-of-systemic-inflammatory-burden
#1
REVIEW
R B Prussick, L Miele
Patients with psoriasis are at an increased risk for nonalcoholic fatty liver disease (NAFLD) compared to the general population. However, the pathophysiology underlying this comorbidity and elucidation of effective treatment strategies are unclear. This review provides insights into the possible role of chronic, low-grade inflammation in the pathogenesis of NAFLD in patients with psoriasis. Both conditions are associated with increased levels of pro-inflammatory adipokines (such as tumor necrosis factor-α and interleukin-6), and hepatokines, and decreased levels of adiponectin, an anti-inflammatory adipokine...
December 13, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/29232663/serum-leptin-resistin-and-adiponectin-concentrations-in-psoriasis-a-meta-analysis-of-observational-studies
#2
Aikaterini Kyriakou, Aikaterini Patsatsi, Dimitrios Sotiriadis, Dimitrios G Goulis
BACKGROUND: Psoriasis is an immune-mediated, inflammatory disease. Adipokines contribute to the regulation of immune-mediated processes and inflammation. OBJECTIVE: The aim of our study was to systematically review the literature for studies that have evaluated the circulating concentrations of adipokines in patients with psoriasis and controls and to meta-analyze the best evidence available. METHODS: Eligible were studies that have assessed leptin, resistin, or adiponectin concentrations in psoriatic patients and a reference group...
December 13, 2017: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/29065479/psoriasis-and-cardiovascular-comorbidities-focusing-on-severe-vascular-events-cardiovascular-risk-factors-and-implications-for-treatment
#3
REVIEW
Stephen Chu-Sung Hu, Cheng-Che E Lan
Psoriasis is a common and chronic inflammatory disease of the skin. It may impair the physical and psychosocial function of patients and lead to decreased quality of life. Traditionally, psoriasis has been regarded as a disease affecting only the skin and joints. More recently, studies have shown that psoriasis is a systemic inflammatory disorder which can be associated with various comorbidities. In particular, psoriasis is associated with an increased risk of developing severe vascular events such as myocardial infarction and stroke...
October 21, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28947858/psoriasis-and-cardiovascular-risk-do-promising-new-biomarkers-have-clinical-impact
#4
REVIEW
Sirje Kaur, Külli Kingo, Mihkel Zilmer
Epidemiological studies suggest an increased prevalence of cardiovascular disease (CVD) in patients with psoriasis (PS). Therefore, emphasis has lately been laid on the necessity for clinical evaluation of the risk of CVD in these patients. The systemic inflammatory markers C-reactive protein (CRP) and interleukin- (IL-) 6, which have long been used to predict future CVD in the general population, are increased manyfold in patients with PS. Lipid abnormalities characterized by elevated triglycerides, low HDL cholesterol, and higher concentrations of LDL cholesterol and its oxidized form are also prevalent in patients...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/28933132/effects-of-secukinumab-on-serum-adipocytokines-preliminary-data
#5
A Fassio, D Gatti, P Gisondi, G Girolomoni, O Viapiana, A Giollo, M Zamboni, M Rossini, L Idolazzi
Psoriatic arthritis (PsA) is a chronic inflammatory disease that affects joints, connective tissues and the axial skeleton. Metabolic syndrome is an independent risk factor for psoriasis (Pso) development and is associated with more severe forms of Pso. Adipocytokines are secreted by white adipose tissue and are thought to link obesity with the development of metabolic and cardiovascular diseases. Secukinumab is a new monoclonal antibody with a different mechanism of action. This antibody selectively binds to and neutralizes interleukin-17 (IL-17) and it has shown efficacy in the treatment of PsA...
September 21, 2017: Reumatismo
https://www.readbyqxmd.com/read/28894050/compounds-of-psoriasis-with-obesity-and-overweight
#6
Agnieszka Owczarczyk-Saczonek, Waldemar Placek
Many epidemiological studies have confirmed the relationship of obesity and psoriasis, and it is believed that obesity is an independent risk factor for its development and is associated with a worse prognosis. Furthermore, the reduction of body weight, using low-calorie diet combined with exercise, reduces the severity of psoriasis.Visceral adipose tissue is the largest endocrine organ, producing proinflammatory cytokines (TNF-α, IL-6, IL-17) and adipokines (adiponectin, omentin, chemerin). They participate in the development of dyslipidemia, insulin resistance, diabetes, and consequently of the cardiovascular diseases...
August 24, 2017: Postȩpy Higieny i Medycyny Doświadczalnej
https://www.readbyqxmd.com/read/28762474/adipokines-psoriasis-systemic-inflammation-and-endothelial-dysfunction
#7
REVIEW
Maeve Lynch, Tomas Ahern, Cheryl M Sweeney, Anna Malara, Anne-Marie Tobin, Donal O'Shea, Brian Kirby
Adipokines are secreted by white adipose tissue, an active endocrine organ, and play a role in the regulation of metabolic functions such as lipid metabolism, inflammation, and vascular homeostasis. Adipokines are secreted in excess in obesity and contribute to the development of associated comorbidities such as metabolic syndrome and atherosclerosis. Psoriasis, a chronic immune-mediated skin disease, is associated with obesity and increased cardiovascular risk. Understanding the role of adipokines in psoriasis may in part explain the association between psoriasis and cardiovascular disease...
November 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/27786588/serum-irisin-levels-in-patients-with-psoriasis
#8
Anna Baran, Hanna Myśliwiec, Paulina Kiluk, Magdalena Świderska, Iwona Flisiak
BACKGROUND: Irisin has been proposed to regulate metabolic diseases such as obesity, diabetes or metabolic syndrome which are common comorbidities in psoriasis. OBJECTIVES: The aim of this study was to evaluate the serum irisin level in psoriasis and elucidate possible associations with disease activity, inflammatory or metabolic parameters and topical treatment. METHODS: Thirty-seven individuals with active plaque-type psoriasis and 15 healthy controls were enrolled...
June 2017: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/27639922/obesity-type-1-diabetes-and-psoriasis-an-autoimmune-triple-flip
#9
REVIEW
Mariagrazia Granata, Evangelia Skarmoutsou, Chiara Trovato, Giulio A Rossi, Maria Clorinda Mazzarino, Fabio D'Amico
Obesity, type 1 diabetes, and psoriasis are wide-ranging health problems. Genetics, epigenetics, and environmental factors together with immune disturbances are involved in these diseases. The white adipose tissue is an active endocrine organ, secreting a wide variety of soluble mediators called adipokines that have a central role in the relationship between adipose tissue and immune system. Inflammatory cytokines, including the IL-23/IL-17 and IL-18 axes, and microRNAs are involved in many processes, including immunity and inflammation, thus having a major role in the onset of these three diseases...
2017: Pathobiology: Journal of Immunopathology, Molecular and Cellular Biology
https://www.readbyqxmd.com/read/27554109/adipokines-in-psoriasis-an-important-link-between-skin-inflammation-and-metabolic-alterations
#10
REVIEW
Kerstin Wolk, Robert Sabat
Psoriasis is a chronic inflammatory skin disease most common in Europe, North America, and Australia. The etiology and pathomechanisms underlying the evolution and persistence of the skin alterations are increasingly being understood and have led to the development of effective anti-psoriatic therapies. Apart from the skin manifestations, psoriasis is associated with the metabolic syndrome (MetS), known to increase the risk of type 2 diabetes mellitus and cardiovascular disorders. Research of the last years demonstrated a dysregulated adipokine balance as an important link between inflammation, MetS, and consequential disorders...
September 2016: Reviews in Endocrine & Metabolic Disorders
https://www.readbyqxmd.com/read/27322922/crosstalk-between-skin-inflammation-and-adipose-tissue-derived-products-pathogenic-evidence-linking-psoriasis-to-increased-adiposity
#11
REVIEW
Andrea Chiricozzi, Annunziata Raimondo, Serena Lembo, Francesca Fausti, Valentina Dini, Antonio Costanzo, Giuseppe Monfrecola, Nicola Balato, Fabio Ayala, Marco Romanelli, Anna Balato
Psoriasis is a chronic skin disorder associated with several comorbid conditions. In psoriasis pathogenesis, the role of some cytokines, including TNF-α and IL-17, has been elucidated. Beside their pro-inflammatory activity, they may also affect glucose and lipid metabolism, possibly promoting insulin resistance and obesity. On the other hand, adipose tissue, secreting adipokines such as chemerin, visfatin, leptin, and adiponectin, not only regulates glucose and lipid metabolism, and endothelial cell function regulation, but it may contribute to inflammation...
December 2016: Expert Review of Clinical Immunology
https://www.readbyqxmd.com/read/27293954/association-of-trabecular-bone-score-with-inflammation-and-adiposity-in-patients-with-psoriasis-effect-of-adalimumab-therapy
#12
José L Hernández, Raquel López-Mejías, Ricardo Blanco, Trinitario Pina, Sheila Ruiz, Isabel Sierra, Begoña Ubilla, Verónica Mijares, Marcos A González-López, Susana Armesto, Alfonso Corrales, Enar Pons, Patricia Fuentevilla, Carmen González-Vela, Miguel Á González-Gay
Studies on trabecular bone score (TBS) in psoriasis are lacking. We aim to assess the association between TBS and inflammation, metabolic syndrome features, and serum adipokines in 29 nondiabetic patients with psoriasis without arthritis, before and after 6-month adalimumab therapy. For that purpose, adjusted partial correlations and stepwise multivariable linear regression analysis were performed. No correlation was found between TBS and disease severity. TBS was negatively associated with weight, BMI, waist perimeter, fat percentage, and systolic and diastolic blood pressure before and after adalimumab...
2016: Journal of Osteoporosis
https://www.readbyqxmd.com/read/27230733/the-triad-psoriasis-obesity-adipokine-profile
#13
REVIEW
S Coimbra, C Catarino, A Santos-Silva
Psoriasis is a chronic inflammatory skin disease, often associated with overweight/obesity. The adipose tissue is a complex organ that secretes several adipokines, involved in the regulation of some metabolic processes, such as lipid metabolism, glucose homeostasis, angiogenesis, blood pressure and inflammation. In obesity, the distribution and function of adipose tissue, and the adipokine profile are altered. The unbalanced production of pro- and anti-inflammatory adipokines in obesity, contributes to the development of a chronic low-grade inflammation state, which seems to favour worsening of psoriasis lesion and a poorer response to treatment...
November 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/26848221/association-of-adipokines-insulin-resistance-hypertension-and-dyslipidemia-in-patients-with-psoriasis-vulgaris
#14
Melis Coban, Levent Tasli, Sebahat Turgut, Seyma Özkan, Melek Tunç Ata, Fulya Akın
BACKGROUND: Systemic inflammation in psoriasis causes insulin resistance and cardiovascular diseases. Adipokines are adipose-tissue-derived factors that are involved in metabolic processes. It is thought that these adipokines are associated with the development of psoriasis. OBJECTIVE: The purpose of this study was to determine the changes in adipokine levels, insulin resistance, hypertension, and dyslipidemia over a 12-week period. METHODS: The study comprised 35 psoriasis patients and 50 controls...
February 2016: Annals of Dermatology
https://www.readbyqxmd.com/read/26783881/anti-inflammatory-action-of-keratinocyte-derived-vaspin-relevance-for-the-pathogenesis-of-psoriasis
#15
Anja Saalbach, Jenny Tremel, Diana Herbert, Katharina Schwede, Elke Wandel, Christine Schirmer, Ulf Anderegg, Annette G Beck-Sickinger, John T Heiker, Stephan Schultz, Thomas Magin, Jan C Simon
Impaired cross talk between keratinocytes (KCs) and immune cells is believed to contribute to the pathogenesis of chronic inflammatory skin diseases, such as psoriasis. We have previously identified KCs as a rich source of the serpin protease inhibitor vaspin (serpinA12), originally described as an adipokine in adipose tissue. Herein, we studied whether dysregulated vaspin expression in KCs contributes to the pathogenesis of psoriasis. We found vaspin expression to be closely associated to epidermal differentiation, with low levels in proliferating KCs and high levels in differentiated cells...
March 2016: American Journal of Pathology
https://www.readbyqxmd.com/read/26476096/sebocytes-differentially-express-and-secrete-adipokines
#16
Dóra Kovács, Marianna Lovászi, Szilárd Póliska, Attila Oláh, Tamás Bíró, Imre Veres, Christos C Zouboulis, Mona Ståhle, Ralph Rühl, Éva Remenyik, Dániel Törőcsik
In addition to producing sebum, sebocytes link lipid metabolism with inflammation at a cellular level and hence, greatly resemble adipocytes. However, so far no analysis was performed to identify and characterize the adipocyte-associated inflammatory proteins, the members of the adipokine family in sebocytes. Therefore, we determined the expression profile of adipokines [adiponectin, interleukin (IL) 6, resistin, leptin, serpin E1, visfatin, apelin, chemerin, retinol-binding protein 4 (RBP4) and monocyte chemoattractant protein 1 (MCP1)] in sebaceous glands of healthy and various disease-affected (acne, rosacea, melanoma and psoriasis) skin samples...
March 2016: Experimental Dermatology
https://www.readbyqxmd.com/read/26293108/the-effect-of-topical-treatment-and-psoriasis-severity-on-serum-retinol-binding-protein-4-levels
#17
A Baran, M Swiderska, I Flisiak
OBJECTIVE: Psoriasis has been considered as chronic systemic disease. Retinol-binding protein-4 (RBP-4) might play a role in psoriasis and its comorbidities. The aim of this study was to investigate the associations between serum RBP-4 levels and disease severity, indicators of inflammation or metabolic syndrome and changes after topical treatment in psoriatic patients. METHODS: Thirty-seven patients with relapse of plaque-type psoriasis and 16 healthy volunteers were examined...
2016: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/26211950/chemerin-a-comprehensive-review-elucidating-the-need-for-cardiovascular-research
#18
REVIEW
David J Ferland, Stephanie W Watts
When chemerin was discovered in 1997, it was relegated to being a protein associated with the normal skin function contrasting the setting of psoriasis. However, with the discovery of multiple receptors for the chemerin protein and a vast collection of associations with various pathologies, chemerin has global influence capable of regulating chemotactic, adipokine, autocrine/paracrine, adipogenic, angiogenic, and reproductive functions. These individual abilities of chemerin are important for understanding its basic pharmacology and physiology, but application of these principles to human pathology relies on the ability of scientists and physicians to view this protein from a much wider, all-encompassing angle...
September 2015: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/26166954/selected-inflammatory-and-metabolic-markers-in-psoriatic-patients-treated-with-goeckerman-therapy
#19
Katerina Kondelkova, Lenka Borska, Ctirad Andrys, Jan Krejsek, Kvetoslava Hamakova, Simona Rendarova, Vit Rehacek, Jan Kremlacek, Zdenek Fiala
Psoriasis is associated with metabolic activity of adipose tissue which produces pro- and anti-inflammatory adipokines. Goeckerman therapy (GT) represents an effective treatment of psoriasis. This study evaluated variation of selected inflammatory and metabolic markers during GT and the relationships between the markers, severity of the disease (PASI score), body mass, and the basic characteristics of the therapy. The study was conducted on a group of patients (n = 32) and on a control group (n = 24). Before GT, we found significantly elevated levels of proinflammatory CRP (p < 0...
2015: Mediators of Inflammation
https://www.readbyqxmd.com/read/26123401/lack-of-association-between-leptin-leptin-receptor-adiponectin-gene-polymorphisms-and-epicardial-adipose-tissue-abdominal-visceral-fat-volume-and-atherosclerotic-burden-in-psoriasis-patients
#20
Tiago Torres, Nuno Bettencourt, Joana Ferreira, Cláudia Carvalho, Denisa Mendonça, Carlos Vasconcelos, Manuela Selores, Berta Silva
CONTEXT: Identifying psoriasis patients who present a higher risk of developing cardiovascular co-morbidities is of upmost importance. Two key adipokines, leptin and adiponectin, may play a role connecting psoriasis and its major co-morbidities. OBJECTIVE: To evaluate the potential contribution of LEPrs2167270(19 G/A), LEPRrs1137100(326 A/G) and ADIPOQrs1501299(276 G/T) gene polymorphisms in psoriasis susceptibility and their influence in epicardial adipose tissue and abdominal visceral fat volume and subclinical atherosclerosis in severe psoriasis patients...
2015: Archives of Physiology and Biochemistry
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