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Psoriasis and adipokines

Mariagrazia Granata, Evangelia Skarmoutsou, Chiara Trovato, Giulio A Rossi, Maria Clorinda Mazzarino, Fabio D'Amico
Obesity, type 1 diabetes, and psoriasis are wide-ranging health problems. Genetics, epigenetics, and environmental factors together with immune disturbances are involved in these diseases. The white adipose tissue is an active endocrine organ, secreting a wide variety of soluble mediators called adipokines that have a central role in the relationship between adipose tissue and immune system. Inflammatory cytokines, including the IL-23/IL-17 and IL-18 axes, and microRNAs are involved in many processes, including immunity and inflammation, thus having a major role in the onset of these three diseases...
September 17, 2016: Pathobiology: Journal of Immunopathology, Molecular and Cellular Biology
Kerstin Wolk, Robert Sabat
Psoriasis is a chronic inflammatory skin disease most common in Europe, North America, and Australia. The etiology and pathomechanisms underlying the evolution and persistence of the skin alterations are increasingly being understood and have led to the development of effective anti-psoriatic therapies. Apart from the skin manifestations, psoriasis is associated with the metabolic syndrome (MetS), known to increase the risk of type 2 diabetes mellitus and cardiovascular disorders. Research of the last years demonstrated a dysregulated adipokine balance as an important link between inflammation, MetS, and consequential disorders...
August 23, 2016: Reviews in Endocrine & Metabolic Disorders
Andrea Chiricozzi, Annunziata Raimondo, Serena Lembo, Francesca Fausti, Valentina Dini, Antonio Costanzo, Giuseppe Monfrecola, Nicola Balato, Fabio Ayala, Marco Romanelli, Anna Balato
INTRODUCTION: Psoriasis is a chronic skin disorder associated with several comorbid conditions. In psoriasis pathogenesis, the role of some cytokines, including TNF-α and IL-17, has been elucidated. Beside their pro-inflammatory activity, they may also affect glucose and lipid metabolism, possibly promoting insulin resistance and obesity. On the other hand, adipose tissue, secreting adipokines such as chemerin, visfatin, leptin, and adiponectin, not only regulates glucose and lipid metabolism, and endothelial cell function regulation, but it may contribute to inflammation...
June 20, 2016: Expert Review of Clinical Immunology
José L Hernández, Raquel López-Mejías, Ricardo Blanco, Trinitario Pina, Sheila Ruiz, Isabel Sierra, Begoña Ubilla, Verónica Mijares, Marcos A González-López, Susana Armesto, Alfonso Corrales, Enar Pons, Patricia Fuentevilla, Carmen González-Vela, Miguel Á González-Gay
Studies on trabecular bone score (TBS) in psoriasis are lacking. We aim to assess the association between TBS and inflammation, metabolic syndrome features, and serum adipokines in 29 nondiabetic patients with psoriasis without arthritis, before and after 6-month adalimumab therapy. For that purpose, adjusted partial correlations and stepwise multivariable linear regression analysis were performed. No correlation was found between TBS and disease severity. TBS was negatively associated with weight, BMI, waist perimeter, fat percentage, and systolic and diastolic blood pressure before and after adalimumab...
2016: Journal of Osteoporosis
S Coimbra, C Catarino, A Santos-Silva
Psoriasis is a chronic inflammatory skin disease, often associated with overweight/obesity. The adipose tissue is a complex organ that secretes several adipokines, involved in the regulation of some metabolic processes, such as lipid metabolism, glucose homeostasis, angiogenesis, blood pressure and inflammation. In obesity, the distribution and function of adipose tissue, and the adipokine profile are altered. The unbalanced production of pro- and anti-inflammatory adipokines in obesity, contributes to the development of a chronic low-grade inflammation state, which seems to favour worsening of psoriasis lesion and a poorer response to treatment...
May 27, 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
Melis Coban, Levent Tasli, Sebahat Turgut, Seyma Özkan, Melek Tunç Ata, Fulya Akın
BACKGROUND: Systemic inflammation in psoriasis causes insulin resistance and cardiovascular diseases. Adipokines are adipose-tissue-derived factors that are involved in metabolic processes. It is thought that these adipokines are associated with the development of psoriasis. OBJECTIVE: The purpose of this study was to determine the changes in adipokine levels, insulin resistance, hypertension, and dyslipidemia over a 12-week period. METHODS: The study comprised 35 psoriasis patients and 50 controls...
February 2016: Annals of Dermatology
Anja Saalbach, Jenny Tremel, Diana Herbert, Katharina Schwede, Elke Wandel, Christine Schirmer, Ulf Anderegg, Annette G Beck-Sickinger, John T Heiker, Stephan Schultz, Thomas Magin, Jan C Simon
Impaired cross talk between keratinocytes (KCs) and immune cells is believed to contribute to the pathogenesis of chronic inflammatory skin diseases, such as psoriasis. We have previously identified KCs as a rich source of the serpin protease inhibitor vaspin (serpinA12), originally described as an adipokine in adipose tissue. Herein, we studied whether dysregulated vaspin expression in KCs contributes to the pathogenesis of psoriasis. We found vaspin expression to be closely associated to epidermal differentiation, with low levels in proliferating KCs and high levels in differentiated cells...
March 2016: American Journal of Pathology
Dóra Kovács, Marianna Lovászi, Szilárd Póliska, Attila Oláh, Tamás Bíró, Imre Veres, Christos C Zouboulis, Mona Ståhle, Ralph Rühl, Éva Remenyik, Dániel Törőcsik
In addition to producing sebum, sebocytes link lipid metabolism with inflammation at a cellular level and hence, greatly resemble adipocytes. However, so far no analysis was performed to identify and characterize the adipocyte-associated inflammatory proteins, the members of the adipokine family in sebocytes. Therefore, we determined the expression profile of adipokines [adiponectin, interleukin (IL) 6, resistin, leptin, serpin E1, visfatin, apelin, chemerin, retinol-binding protein 4 (RBP4) and monocyte chemoattractant protein 1 (MCP1)] in sebaceous glands of healthy and various disease-affected (acne, rosacea, melanoma and psoriasis) skin samples...
March 2016: Experimental Dermatology
A Baran, M Swiderska, I Flisiak
OBJECTIVE: Psoriasis has been considered as chronic systemic disease. Retinol-binding protein-4 (RBP-4) might play a role in psoriasis and its comorbidities. The aim of this study was to investigate the associations between serum RBP-4 levels and disease severity, indicators of inflammation or metabolic syndrome and changes after topical treatment in psoriatic patients. METHODS: Thirty-seven patients with relapse of plaque-type psoriasis and 16 healthy volunteers were examined...
2016: Journal of Dermatological Treatment
David J Ferland, Stephanie W Watts
When chemerin was discovered in 1997, it was relegated to being a protein associated with the normal skin function contrasting the setting of psoriasis. However, with the discovery of multiple receptors for the chemerin protein and a vast collection of associations with various pathologies, chemerin has global influence capable of regulating chemotactic, adipokine, autocrine/paracrine, adipogenic, angiogenic, and reproductive functions. These individual abilities of chemerin are important for understanding its basic pharmacology and physiology, but application of these principles to human pathology relies on the ability of scientists and physicians to view this protein from a much wider, all-encompassing angle...
September 2015: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
Katerina Kondelkova, Lenka Borska, Ctirad Andrys, Jan Krejsek, Kvetoslava Hamakova, Simona Rendarova, Vit Rehacek, Jan Kremlacek, Zdenek Fiala
Psoriasis is associated with metabolic activity of adipose tissue which produces pro- and anti-inflammatory adipokines. Goeckerman therapy (GT) represents an effective treatment of psoriasis. This study evaluated variation of selected inflammatory and metabolic markers during GT and the relationships between the markers, severity of the disease (PASI score), body mass, and the basic characteristics of the therapy. The study was conducted on a group of patients (n = 32) and on a control group (n = 24). Before GT, we found significantly elevated levels of proinflammatory CRP (p < 0...
2015: Mediators of Inflammation
Tiago Torres, Nuno Bettencourt, Joana Ferreira, Cláudia Carvalho, Denisa Mendonça, Carlos Vasconcelos, Manuela Selores, Berta Silva
CONTEXT: Identifying psoriasis patients who present a higher risk of developing cardiovascular co-morbidities is of upmost importance. Two key adipokines, leptin and adiponectin, may play a role connecting psoriasis and its major co-morbidities. OBJECTIVE: To evaluate the potential contribution of LEPrs2167270(19 G/A), LEPRrs1137100(326 A/G) and ADIPOQrs1501299(276 G/T) gene polymorphisms in psoriasis susceptibility and their influence in epicardial adipose tissue and abdominal visceral fat volume and subclinical atherosclerosis in severe psoriasis patients...
2015: Archives of Physiology and Biochemistry
Anna Baran, Iwona Flisiak, Jerzy Jaroszewicz, Magdalena Świderska
INTRODUCTION: Psoriasis is an inflammatory and chronic skin disease associated with obesity, cardiovascular diseases, diabetes and metabolic syndrome. Adipokines, as bioactive substances secreted from adipose tissue, are involved in various metabolic diseases. AIM: To investigate the association between psoriasis severity and serum adiponectin and leptin levels in patients with psoriasis. MATERIAL AND METHODS: Serum fasting adiponectin and leptin levels were examined by an enzyme-linked immunosorbent assay in 49 patients with relapse of plaque-type psoriasis and 16 healthy controls...
April 2015: Postȩpy Dermatologii i Alergologii
Huiyun Huang, Erdong Shen, Shiqing Tang, Xingyou Tan, Xiuli Guo, Qiang Wang, Hongwei Ding
BACKGROUND: Recent studies implicate adipokines in the pathogenesis of inflammatory diseases, including psoriasis. In this study we evaluated the significance of serum resistin levels in psoriasis patients using a meta-analysis approach.223 METHODS: Relevant articles were retrieved by searching the following English and Chinese databases: Cochrane Library, PubMed, Springer Link, Chinese Biomedical Database (CBM) and Chinese National Knowledge Infrastructure (CNKI). The retrieved studies were subjected to a thorough screening procedure to identify case-control studies that contained the required data...
2015: Lipids in Health and Disease
T Pina, F Genre, R Lopez-Mejias, S Armesto, B Ubilla, V Mijares, T Dierssen-Sotos, M A Gonzalez-Lopez, M C Gonzalez-Vela, R Blanco, J L Hernández, J Llorca, M A Gonzalez-Gay
BACKGROUND: Altered secretion patterns of proinflammatory adipokines may influence the increased risk of cardiovascular mortality observed in patients with chronic inflammatory diseases. OBJECTIVE: To determine whether two adipokines, leptin and resistin, correlate with metabolic syndrome features and disease severity in psoriatic patients who underwent anti-TNF-α therapy. METHODS: Prospective study of consecutive non-diabetic patients with moderate-to-severe psoriasis who completed 6 months of therapy with anti-TNF-α- adalimumab...
October 2015: Journal of the European Academy of Dermatology and Venereology: JEADV
C Zhang, K J Zhu, J L Liu, G X Xu, W Liu, F X Jiang, H F Zheng, C Quan
Previous studies have suggested that psoriasis is associated with individuals who are overweight or obese. Omentin is a recently discovered adipokine that is involved in chronic inflammatory processes. This study evaluated the relationship between omentin and psoriasis, focusing on omentin-1 serum levels, skin expression of omentin-1, and omentin-1 gene polymorphism (rs2274907; Val109Asp). Levels of omentin-1 in serum samples from 44 patients with psoriasis and 38 healthy controls were analyzed by enzyme-linked immunosorbent assay...
July 2015: Archives of Dermatological Research
Magdalena Banas, Aneta Zegar, Mateusz Kwitniewski, Katarzyna Zabieglo, Joanna Marczynska, Monika Kapinska-Mrowiecka, Melissa LaJevic, Brian A Zabel, Joanna Cichy
Chemerin is a protein ligand for the G protein-coupled receptor CMKLR1 and also binds to two atypical heptahelical receptors, CCRL2 and GPR1. Chemerin is a leukocyte attractant, adipokine, and antimicrobial protein. Although chemerin was initially identified as a highly expressed gene in healthy skin keratinocytes that was downregulated during psoriasis, the regulation of chemerin and its receptors in the skin by specific cytokines and microbial factors remains unexplored. Here we show that chemerin, CMKLR1, CCRL2 and GPR1 are expressed in human and mouse epidermis, suggesting that this tissue may be both a source and target for chemerin mediated effects...
2015: PloS One
T Pina, F Genre, R Lopez-Mejias, S Armesto, B Ubilla, V Mijares, T Dierssen-Sotos, A Corrales, M A Gonzalez-Lopez, M C Gonzalez-Vela, R Blanco, J Llorca, M A Gonzalez-Gay
BACKGROUND: Retinol-binding protein-4 (RBP4), an adipokine considered as an emerging cardiometabolic risk factor, is increased in patients with moderate-to-severe psoriasis. OBJECTIVE: In this study, we aimed to establish the effect of anti-TNF-α therapy on RBP4 levels in patients with moderate-to-severe psoriasis. We also assessed if RBP4 levels correlate with metabolic syndrome features and disease severity in these patients. METHODS: Prospective study on a series of consecutive non-diabetic patients with moderate-to-severe psoriasis who completed 6 months of therapy with adalimumab...
January 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
Francesco Mariani, Luca Roncucci
Chemerin is an adipokine secreted by adipocytes and associated with obesity, insulin resistance and metabolic syndrome. Different chemerin fragments with pro- or anti-inflammatory action can be produced, depending on the class of proteases predominating in the microenvironment. Chemerin binds to three receptors, especially to chemR23, expressed on various cells, as dendritic cells, macrophages and natural killer cells, regulating chemotaxis towards the site of inflammation and activation status. Recently, the chemerin/chemR23 axis has attracted particular attention for the multiple roles related to the control of inflammation, metabolism and cancerogenesis in different organs and systems as lung (allergy and cancer), skin (psoriasis, lupus, cancer, wound repair), cardiovascular system (lipid profile and atherosclerosis), reproductive apparatus (polycystic ovary syndrome, follicular homoeostasis), and digestive tract (inflammatory bowel diseases and cancer)...
February 2015: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
Caitriona Ryan, Brian Kirby
There is evidence that patients with moderate to severe psoriasis have an increased risk of conditions such as cardiovascular disease, obesity, diabetes mellitus, and metabolic syndrome. The precise mechanisms underlying the observed increase in cardiovascular disease in psoriasis remain to be defined but inflammatory pathways mutual to both conditions are probably involved. Suppression of systemic inflammation in psoriasis could help reduce cardiovascular inflammation but robust evidence is still lacking evidence is lacking...
January 2015: Dermatologic Clinics
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