P Funchain, Y Ni, B Heald, B Bungo, M Arbesman, T R Behera, S McCormick, J M Song, L B Kennedy, S M Nielsen, E D Esplin, E Nizialek, J Ko, C M Diaz-Montero, B Gastman, A J Stratigos, M Artomov, H Tsao, J Arbesman
BACKGROUND: Prior studies have estimated a small number of individuals with melanoma (2-2.5%) have germline cancer predisposition, yet a recent twin study suggested melanoma has the highest hereditability among cancers. OBJECTIVE: To determine the incidence of hereditary melanoma and characterize the spectrum of cancer predisposition genes that may increase the risk of melanoma. METHODS: 400 individuals with melanoma and personal or family history of cancers underwent germline testing of >80 cancer predisposition genes...
March 19, 2024: Journal of the American Academy of Dermatology