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https://www.readbyqxmd.com/read/28930331/ils-through-the-looking-glass-electrostatics-and-structure-probed-using-charge-inverted-ionic-liquid-pairs
#1
Tiago F C Cruz, Karina Shimizu, José M S S Esperança, Luís Paulo N Rebelo, Pedro T Gomes, José N Canongia Lopes
Ionic liquids combining potassium cations with 1-alkyl-3-methylcyclopentadienyl anions, K[CnC1Cp] (n = 4, 6) have been synthesized. Differential scanning calorimetry measurements have shown that K[C4C1Cp] and K[C6C1Cp] melt without decomposition at around 90 °C. These two ionic liquids are the charge-inverted counterparts of [C4C1Im]Cl and [C6C1Im]Cl, two common ionic liquids. The concept of charge-inverted ionic pairs is used to explore the nature of the interactions and structure in different ionic compounds, from simple alkali halide salts to ionic liquids based on complex molecular ions...
September 20, 2017: Faraday Discussions
https://www.readbyqxmd.com/read/28929973/vermont-a-multi-perspective-visual-interactive-platform-for-mutational-analysis
#2
Alexandre V Fassio, Pedro M Martins, Samuel da S Guimarães, Sócrates S A Junior, Vagner S Ribeiro, Raquel C de Melo-Minardi, Sabrina de A Silveira
BACKGROUND: A huge amount of data about genomes and sequence variation is available and continues to grow on a large scale, which makes experimentally characterizing these mutations infeasible regarding disease association and effects on protein structure and function. Therefore, reliable computational approaches are needed to support the understanding of mutations and their impacts. Here, we present VERMONT 2.0, a visual interactive platform that combines sequence and structural parameters with interactive visualizations to make the impact of protein point mutations more understandable...
September 13, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/28929614/plantar-keratoderma-climatericum-successful-improvement-with-a-topical-estriol-cream
#3
Pedro Mendes-Bastos
Keratoderma climatericum affects menopausal women, and the diagnosis relies on typical clinical findings and exclusion of other potential causes of acquired keratoderma. Although its pathophysiology is still unknown, there has been speculation about its relation to hormonal dysregulation (possibly a local estrogen deficiency) since the 1930s. A female patient with long-lasting keratoderma climatericum was initially prescribed a topical 50% urea ointment and clobetasol propionate 0.05% ointment, with just a slight improvement after 2 months of daily use...
September 19, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/28929535/extracellular-acidosis-selectively-inhibits-pharmacomechanical-coupling-induced-by-carbachol-in-strips-of-rat-gastric-fundus
#4
Daniel Maia Nogueira de Oliveira, Francisco José Batista-Lima, Emanuella Carvalho Feitosa, Alexandre Havt, Moisés Tolentino Bento da Silva, Armênio Aguiar Dos Santos, Pedro Jorge Caldas Magalhães
Acute acidosis that results from short-term exercise delays gastric emptying in rats and decreases the responsiveness to carbachol in gastric fundus strips. The regulation of cytosolic Ca(2+) levels appears to be a mechanism of action of acidosis. The present study investigated the way in which acidosis interferes with gastric smooth muscle contractions. Rat gastric fundus isolated strips at pH 6.0 presented a lower magnitude of carbachol-induced contractions compared with preparations at pH 7.4. This lower magnitude was absent in carbachol-stimulated duodenum and KCl-stimulated gastric fundus strips...
September 19, 2017: Experimental Physiology
https://www.readbyqxmd.com/read/28929253/positive-rheotaxis-extended-drop-a-one-step-procedure-to-select-and-recover-sperm-with-mature-chromatin-for-intracytoplasmic-sperm-injection
#5
Hamilton De Martin, Marcello S Cocuzza, Bruno C Tiseo, Guilherme J A Wood, Eduardo P Miranda, Pedro A A Monteleone, José Maria Soares, Paulo C Serafini, Miguel Srougi, Edmund C Baracat
PURPOSE: The purpose of this study was to develop a novel one-step ICSI approach to select sperm with better chromatin maturity than the conventional method. METHODS: This was a pilot diagnostic study, which prospectively recruited men during a 6-month period in a University-affiliated infertility centre. Forty consecutive semen samples were provided for analysis. The positive rheotaxis extended drop (PRED) was set up creating a pressure and viscosity gradient. Each semen sample was divided into four aliquots: one aliquot for density gradient centrifugation (DGC), two aliquots for PRED (fresh semen (PRED-FS) and processed semen (PRED-DGC)), and one aliquot as the control (FS)...
September 19, 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/28929118/natriuretic-peptide-system-activation-in-acute-heart-failure-patients-with-diabetes
#6
Filipe M Cunha, Joana Pereira, Pedro Marques, Helena Moreira, Pedro Rodrigues, Maria João Pinto, Patrícia Lourenço, Paulo Bettencourt
BACKGROUND: Elevated B-type natriuretic peptide (BNP) is a hallmark in heart failure (HF). Diabetic patients with chronic HF seem to have higher BNP than nondiabetics. We studied, in acute HF, if BNP levels are different between diabetics and nondiabetics. METHODS: From a prospectively recruited population of acute HF patients, we selected a convenience sample. In pair-matched analysis, each diabetic patient was matched with a nondiabetic of the same age (±1 year), gender, and according to left ventricular systolic dysfunction...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/28928992/dental-implant-in-the-canalis-sinuosus-a-case-report-and-review-of-the-literature
#7
José Alcides Arruda, Pedro Silva, Luciano Silva, Pâmella Álvares, Leni Silva, Ricardo Zavanelli, Cleomar Rodrigues, Marleny Gerbi, Ana Paula Sobral, Marcia Silveira
The canalis sinuosus is a neurovascular canal, a branch of nerve of infraorbital canal, through which the anterior superior alveolar nerve passes and then leans medially in course between the nasal cavity and the maxillary sinus, reaching the premaxilla in the canine and incisor region. The purpose of this article is to report a case with the presence of canalis sinuosus, in order to alert and guide professionals and discuss the morphology of this anatomical variation avoiding trans- and postsurgical disorders in dental implants...
2017: Case Reports in Dentistry
https://www.readbyqxmd.com/read/28928938/the-elixir-excelerate-train-the-trainer-pilot-programme-empower-researchers-to-deliver-high-quality-training
#8
Sarah L Morgan, Patricia M Palagi, Pedro L Fernandes, Eija Koperlainen, Jure Dimec, Diana Marek, Lee Larcombe, Gabriella Rustici, Teresa K Attwood, Allegra Via
One of the main goals of the ELIXIR-EXCELERATE project from the European Union's Horizon 2020 programme is to support a pan-European training programme to increase bioinformatics capacity and competency across ELIXIR Nodes. To this end, a Train-the-Trainer (TtT) programme has been developed by the TtT subtask of EXCELERATE's Training Platform, to try to expose bioinformatics instructors to aspects of pedagogy and evidence-based learning principles, to help them better design, develop and deliver high-quality training in future...
2017: F1000Research
https://www.readbyqxmd.com/read/28928410/ang-1-7-is-an-endogenous-%C3%AE-arrestin-biased-agonist-of-the-at1-receptor-with-protective-action-in-cardiac-hypertrophy
#9
Larissa B Teixeira, Lucas T Parreiras-E-Silva, Thiago Bruder-Nascimento, Diego A Duarte, Sarah C Simões, Rafael M Costa, Deisy Y Rodríguez, Pedro A B Ferreira, Carlos A A Silva, Emiliana P Abrao, Eduardo B Oliveira, Michel Bouvier, Rita C Tostes, Claudio M Costa-Neto
The renin-angiotensin system (RAS) plays a key role in the control of vasoconstriction as well as sodium and fluid retention mediated mainly by angiotensin (Ang) II acting at the AT1 receptor (AT1R). Ang-(1-7) is another RAS peptide, identified as the endogenous ligand of the Mas receptor and known to counterbalance many of the deleterious effects of AngII. AT1R signaling triggered by β-arrestin-biased agonists has been associated to cardioprotection. Because position 8 in AngII is important for G protein activation, we hypothesized that Ang-(1-7) could be an endogenous β-arrestin-biased agonist of the AT1R...
September 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28927882/treatment-of-hand-macrodactyly-with-resection-and-toe-transfers
#10
Pedro C Cavadas, Alessandro Thione
Macrodactyly is an uncommon congenital hand condition that can be difficult to treat and that can have a profound negative impact on patients and their families. Although many treatments have been described, results tend to be inconsistent. The authors report a case in which a combination of ray resection, partial finger resection, and toe transfer resulted in a 4-digit hand with acceptable function and cosmesis.
September 16, 2017: Journal of Hand Surgery
https://www.readbyqxmd.com/read/28927856/migration-flow-and-its-impact-on-tuberculosis-notification-in-portugal
#11
Ana Dias, Rita Gaio, Pedro Sousa, Marta Gomes, Olena Oliveira, Raquel Duarte
INTRODUCTION: Tuberculosis notification in Portugal has decreased in the last few years. As a consequence of the economic crisis, emigration has increased and immigration has decreased. Immigrants are a risk group for tuberculosis. Most emigrants are 20-44 years old and belong to the age group most affected by tuberculosis. OBJECTIVE: To describe the decrease in tuberculosis notification in Portugal over the last years from a demographical point of view. METHODS: Mathematical analysis was performed to quantify the effect of the migration movements (separately and simultaneously) on tuberculosis notification in Portugal from 2008 to 2014...
September 16, 2017: Archivos de Bronconeumología
https://www.readbyqxmd.com/read/28927671/quality-language-subdiscipline-and-promotion-were-associated-with-article-accesses-on-physiotherapy-evidence-database-pedro
#12
Tiê P Yamato, Mohit Arora, Matthew L Stevens, Mark R Elkins, Anne M Moseley
OBJECTIVE: To quantify the relationship between the number of times articles are accessed on the Physiotherapy Evidence Database (PEDro) and the article characteristics. A secondary aim was to examine the relationship between accesses and the number of citations of articles. METHOD: The study was conducted to derive prediction models for the number of accesses of articles indexed on PEDro from factors that may influence an article's accesses. All articles available on PEDro from August 2014 to January 2015 were included...
August 12, 2017: Physiotherapy
https://www.readbyqxmd.com/read/28926981/antibiofilm-activity-and-mechanism-of-action-of-the-disinfectant-chloramine-t-on-candida-spp-and-its-toxicity-against-human-cells
#13
Gabriela Lacet Silva Ferreira, Pedro Luiz Rosalen, Larissa Rangel Peixoto, Ana Luiza Alves de Lima Pérez, Fabíola Galbiatti de Carvalho Carlo, Lúcio Roberto Cançado Castellano, Jefferson Muniz de Lima, Irlan Almeida Freires, Edeltrudes de Oliveira Lima, Ricardo Dias de Castro
We evaluated the antifungal and anti-biofilm activity, mechanism of action and cytotoxicity of chloramine T trihydrate (CAT) against Candida spp. The Minimum Inhibitory and Fungicidal Concentrations (MIC/MFC) of CAT were determined. Changes in CAT-treated C. albicans growth kinetics and micromorphology were evaluated, as well as the mechanism of action, and its effects on biofilm. Cytotoxicity was assessed by the hemolysis method. The data were analyzed by inferential statistics (p ≤ 0.05). CAT showed antifungal activity against all strains, with MIC values ranging between 1...
September 17, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28926515/is-the-age-at-menopause-a-cause-of-sexual-dysfunction-a-brazilian-population-based-study
#14
Caio Lett, Ana L R Valadares, Luiz F Baccaro, Adriana O Pedro, Jeffrey L Filho, Marcelo Lima, Lucia Costa-Paiva
OBJECTIVES: The aim of the study was to evaluate the association between age at menopause and sexual dysfunction and the components of sexual function in postmenopausal women. METHODS: In this cross-sectional population-based study, data of 540 women aged 45 to 60 years regarding the age they were when they achieved menopause and its association with sexual dysfunction (evaluated using the Short Personal Experiences Questionnaire) were obtained through interviews...
September 18, 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/28926336/extensive-atypical-hsv-2-ulceration-of-the-finger
#15
Nélia Cunha, Pedro Simões, Vasco Serrão
No abstract text is available yet for this article.
August 31, 2017: Acta Médica Portuguesa
https://www.readbyqxmd.com/read/28926331/-assessment-of-urinary-incontinence-in-pregnancy-and-postpartum-observational-study
#16
Juliana Rocha, Pedro Brandão, Anabela Melo, Silvia Torres, Lurdes Mota, Fernanda Costa
INTRODUCTION: The urinary incontinence can affect up to 50% of women at some stage of their lives, particularly during pregnancy and postpartum. This study was designed in order to identify and assess the prevalence and risk factors for urinary incontinence during the third trimester of pregnancy and three months postpartum. MATERIAL AND METHODS: Observational and cross-sectional study. The population of the study was composed of 268 women who delivered and were admitted to the Centro Hospitalar Tâmega e Sousa in the years 2013 and 2014, and who agreed to participate in this study...
August 31, 2017: Acta Médica Portuguesa
https://www.readbyqxmd.com/read/28925557/analysis-of-multiple-haloarchaeal-genomes-suggests-that-the-quinone-dependent-respiratory-nitric-oxide-reductase-is-an-important-source-of-nitrous-oxide-in-hypersaline-environments
#17
Javier Torregrosa-Crespo, Pedro González-Torres, Vanesa Bautista, Julia M Esclapez, Carmen Pire, Mónica Camacho, María José Bonete, David J Richardson, Nicholas J Watmough, Rosa María Martínez-Espinosa
Microorganisms, including Bacteria and Archaea, play a key role in denitrification, which is the major mechanism by which fixed nitrogen returns to the atmosphere from soil and water. Whilst the enzymology of denitrification is well understood in Bacteria, the details of the last two reactions in this pathway, which catalyse the reduction of nitric oxide (NO) via nitrous oxide (N2 O) to nitrogen (N2 ), are little studied in Archaea, and hardly at all in haloarchaea. This work describes an extensive interspecies analysis of both complete and draft haloarchaeal genomes aimed at identifying the genes that encode respiratory nitric oxide reductases (Nors)...
September 19, 2017: Environmental Microbiology Reports
https://www.readbyqxmd.com/read/28925554/monitoring-of-sesamia-nonagrioides-resistance-to-mon%C3%A2-810-maize-in-the-european-union-lessons-from-a-long-term-harmonized-plan
#18
Gema P Farinós, Pedro Hernández-Crespo, Félix Ortego, Pedro Castañera
BACKGROUND: MON 810 maize, which expresses the insecticidal protein Cry1Ab, is a highly effective method to control Sesamia nonagrioides (Lefèbvre), a key maize pest in Mediterranean countries. Monitoring programs to assess the potential development of resistance of target pests to Bt maize are mandatory in the European Union (EU). Here we report the results of the S. nonagrioides resistance monitoring plan implemented for MON 810 maize in the EU between 2004-2015 and reassess the different components of this long-term harmonized plan...
September 19, 2017: Pest Management Science
https://www.readbyqxmd.com/read/28925060/current-food-allergenic-risk-assessment-is-it-fit-for-novel-foods-status-quo-and-identification-of-gaps
#19
REVIEW
Gabriel Mazzucchelli, Thomas Holzhauser, Tanja Cirkovic-Velickovic, Araceli Diaz-Perales, Elena Molina, Paola Roncada, Pedro Rodrigues, Kitty Verhoeckx, Karin Hoffmann-Sommergruber
Food allergies are recognised as a global health concern. In order to protect allergic consumers from severe symptoms, allergenic risk assessment for well known foods and foods containing genetically modified ingredients was installed. However, population is steadily growing and there is a rising need to provide adequate protein-based foods, including novel sources, not yet used for human consumption. In this context safety issues such as a potential increased allergenic risk need to be assessed before marketing novel food sources...
September 19, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28924968/predictive-value-of-serum-carbohydrate-antigen-19-9-ca19-9-for-early-mortality-in-advanced-pancreatic-cancer
#20
Pedro L S Usón Junior, Donato Callegaro-Filho, Diogo D G Bugano, Fernando Moura, Fernando C Maluf
INTRODUCTION: Levels of carbohydrate antigen 19-9 (CA19-9) in metastatic pancreatic cancer are used in daily practice as a marker of response to chemotherapy. The association between CA19-9 levels and mortality remains uncertain. This study sought to determine the most accurate level of CA19-9 associated with early mortality, both at diagnosis and during the course of metastatic disease. METHODS: This research is a retrospective analysis of 64 patients with metastatic adenocarcinoma of the pancreas evaluated from January 2010 to December 2015...
September 19, 2017: Journal of Gastrointestinal Cancer
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