keyword
https://read.qxmd.com/read/37821776/impact-of-risk-minimisation-measures-on-valproate-use-among-women-of-reproductive-age-in-latvia-between-2013-and-2020-a-7-year-nationwide-prescription-database-study
#21
JOURNAL ARTICLE
Ieva Rutkovska, Andis Seilis, Zane Neikena, Elita Poplavska
BACKGROUND: A relevant safety concern for the use of valproate (VPA) in women of reproductive age is its teratogenicity. In 2014 European Medicines Agency (EMA) introduced risk minimisation measures (RMMs) to reduce the VPA use by women of reproductive age, where the impact on VPA use was not as large as expected. In 2018, the EMA introduced additional RMMs, and it is essential to assess impact of these interventions. OBJECTIVE: The objective of this study was to evaluate the impact of the EMA-published RMMs in 2014 and 2018 on the prevalence of VPA use and to describe trends in the prevalence rate and incidence proportion of VPA use in epilepsy, bipolar disorder and off-label indications in Latvia...
October 12, 2023: Drugs—Real World Outcomes
https://read.qxmd.com/read/37782485/levetiracetam-vs-lamotrigine-as-first-line-antiseizure-medication-in-female-patients-with-idiopathic-generalized-epilepsy
#22
MULTICENTER STUDY
Emanuele Cerulli Irelli, Enrico Cocchi, Alessandra Morano, Joanna Gesche, Roberto H Caraballo, Simona Lattanzi, Gionata Strigaro, Cecilia Catania, Edoardo Ferlazzo, Angelo Pascarella, Sara Casciato, Pierpaolo Quarato, Chiara Pizzanelli, Patrizia Pulitano, Loretta Giuliano, Veronica Viola, Barbara Mostacci, Francesco Fortunato, Carla Marini, Giancarlo Di Gennaro, Antonio Gambardella, Angelo Labate, Francesca F Operto, Anna T Giallonardo, Betul Baykan, Christoph P Beier, Carlo Di Bonaventura
IMPORTANCE: After the recent limitations to prescribing valproate, many studies have highlighted the challenging management of female patients of reproductive age with idiopathic generalized epilepsy (IGE). However, no study, to the authors' knowledge, has addressed the comparative effectiveness of alternative antiseizure medications (ASMs) in these patients. OBJECTIVE: To compare the effectiveness and safety of levetiracetam and lamotrigine as initial monotherapy in female patients of childbearing age with IGE...
November 1, 2023: JAMA Neurology
https://read.qxmd.com/read/37684052/management-of-epilepsy-during-pregnancy-and-lactation
#23
REVIEW
Omotola A Hope, Katherine Mj Harris
Epilepsy is a group of neurological diseases characterized by susceptibility to recurrent seizures. Antiseizure medications (ASMs) are the mainstay of treatment, but many antiseizure medications with variable safety profiles have been approved for use. For women with epilepsy in their childbearing years, the safety profile is important for them and their unborn children, because treatment is often required to protect them from seizures during pregnancy and lactation. Since no large randomized controlled trials have investigated safety in this subgroup of people with epilepsy, pregnancy registries, cohort and case-control studies from population registries, and a few large prospective cohort studies have played an important role...
September 8, 2023: BMJ: British Medical Journal
https://read.qxmd.com/read/37647086/monotherapy-treatment-of-epilepsy-in-pregnancy-congenital-malformation-outcomes-in-the-child
#24
REVIEW
Rebecca Bromley, Naghme Adab, Matt Bluett-Duncan, Jill Clayton-Smith, Jakob Christensen, Katherine Edwards, Janette Greenhalgh, Ruaraidh A Hill, Cerian F Jackson, Sonia Khanom, Ronan N McGinty, Catrin Tudur Smith, Jennifer Pulman, Anthony G Marson
BACKGROUND: Prenatal exposure to certain anti-seizure medications (ASMs) is associated with an increased risk of major congenital malformations (MCM). The majority of women with epilepsy continue taking ASMs throughout pregnancy and, therefore, information on the potential risks associated with ASM treatment is required. OBJECTIVES: To assess the effects of prenatal exposure to ASMs on the prevalence of MCM in the child. SEARCH METHODS: For the latest update of this review, we searched the following databases on 17 February 2022: Cochrane Register of Studies (CRS Web), MEDLINE (Ovid, 1946 to February 16, 2022), SCOPUS (1823 onwards), and ClinicalTrials...
August 29, 2023: Cochrane Database of Systematic Reviews
https://read.qxmd.com/read/37638195/pregnancy-characteristics-and-adverse-outcomes-in-offspring-of-women-with-epilepsy-a-prospective-registry-study-from-mainland-china
#25
JOURNAL ARTICLE
Rui Li, Qian Chen, Xing Cao, Hua Yan, Pei Wang, Qun Huang, Xiaoyi Li, Fang Chen, Yangchao Li, Qingxia Kong, Chonglun Guo, Qi Zhang, Qiulei Hong, Yong Liu, Xiaoli Xiong, Yanbing Han, Xiaohua Xiao, Kuiyun Wang, Xunyi Wu, Xi Zhu, Qing Zhang, Lei Chen
OBJECTIVE: This study aimed to explore the influencing factors of adverse outcomes in the offspring of women with epilepsy (WWE) and to analyze the changes brought about by the epilepsy knowledge popularization campaign in China (EKPCIC). METHODS: This nested case-control study focused on WWE and their offspring from a female epilepsy cohort in mainland China. From January 2009 to August 2022, WWE was prospectively enrolled in 32 study centers. This study aimed to observe the health outcomes of their offspring within 1 year of age...
2023: Frontiers in Neurology
https://read.qxmd.com/read/37634500/valproate-prescribed-to-reproductive-age-women-in-ambulatory-care-analysis-of-2018-2019-national-ambulatory-health-care-data
#26
JOURNAL ARTICLE
Abid Rizvi, Faisal Shaan, Mohammad Reyazuddin
No abstract text is available yet for this article.
August 22, 2023: Primary Care Companion to CNS Disorders
https://read.qxmd.com/read/37632171/prescription-of-sodium-valproate-to-women-of-childbearing-potential-in-southern-district-mental-health-services-in-new-zealand
#27
JOURNAL ARTICLE
Julia Corfe-Tan, Linda McLay, Charlie Mentzel
OBJECTIVE: This study aimed to assess the adherence to guidelines in the prescription of sodium valproate (SV) to women of childbearing potential (WOCP) in Southern District Mental Health Services (SMHS) in New Zealand (NZ). METHODS: Electronic records of women aged 18-54 who were newly prescribed SV by SMHS between the 1st of January 2018 and the 31st of December 2019, were retrospectively reviewed. Documentation of the following criteria was examined: pre-commencement pregnancy test, education education on the teratogenic potential of SV and/or the importance of avoiding unplanned pregnancy, information on contraception, and the rationale for prescribing SV over alternative treatments...
August 25, 2023: Australasian Psychiatry: Bulletin of Royal Australian and New Zealand College of Psychiatrists
https://read.qxmd.com/read/37575009/antiseizure-medications-as-migraine-preventatives-a-call-for-action-for-a-teratogenic-and-neurodevelopmental-risk-removal
#28
JOURNAL ARTICLE
William Wells-Gatnik, Paolo Martelletti
INTRODUCTION: A recent study has demonstrated an increased risk of neurodevelopmental disorders, including autism spectrum disorder, in individuals exposed to either valproate or topiramate monotherapy. Regulatory bodies have initiated a review to reassess the safety of topiramate exposure during pregnancy. These novel findings raise concerns regarding the recommendation of antiseizure medications in women of childbearing potential. This manuscript highlights current research defining concerns specific to the use of valproate and topiramate in women of childbearing potential...
August 14, 2023: Expert Opinion on Drug Safety
https://read.qxmd.com/read/37513857/a-5-year-study-of-antiseizure-medications-asms-monitoring-in-patients-with-neuropsychiatric-disorders-in-an-italian-clinical-center
#29
JOURNAL ARTICLE
Letizia Biso, Marco Carli, Shivakumar Kolachalam, Giorgio Monticelli, Pasquale Fabio Calabrò, Antonello di Paolo, Filippo Sean Giorgi, Guido Bocci, Marco Scarselli
Despite receiving appropriate antiseizure medications (ASMs), a relevant percentage of neuropsychiatric patients do not benefit from this approach, and one reason is subtherapeutic ASMs plasma concentration (C(p)) due to improper drug adherence, interindividual pharmacokinetic differences, or metabolic interactions among different drugs. For these reasons, therapeutic drug monitoring (TDM) by measuring ASMs C(p) is an effective tool that improves pharmacological therapies in clinical practice. Based on these premises, in the present real-world study, we analyzed the C(p) of the most used ASMs in diverse medical conditions, which were assayed during the years 2018-2022 at the University Hospital of Pisa, including about 24,000 samples...
June 29, 2023: Pharmaceuticals
https://read.qxmd.com/read/37510861/psychiatric-treatment-in-pregnancy-a-narrative-review
#30
REVIEW
Iga Gruszczyńska-Sińczak, Katarzyna Wachowska, Katarzyna Bliźniewska-Kowalska, Piotr Gałecki
Pregnancy, childbirth and the puerperium are a series of transformations and huge changes in a woman's life, which may also be accompanied by various mental problems. Very often, women experiencing mental disorders during this period and their doctors face a decision on safety of treatment. The purpose of the following review was to assess the safety of treatment during pregnancy. Internet scientific database PubMed was searched. There are groups of psychiatric medications contraindicated during pregnancy such as valproates as well as relatively safe ones such as selective serotonin reuptake inhibitors (SSRIs) or antipsychotics...
July 18, 2023: Journal of Clinical Medicine
https://read.qxmd.com/read/37501242/dental-and-oro-facial-features-of-foetal-anticonvulsant-syndrome
#31
JOURNAL ARTICLE
Hetal Shukla, Alison Meldrum, Dorothy Boyd
AIM: Emerging evidence suggests dental/oro-facial anomalies are features of Foetal Anticonvulsant Syndrome (FACS) and have an impact on quality of life. Currently there is limited research on these, and no Aotearoa New Zealand data on FACS overall. This study aimed to collect national data on the dental and oro-facial features of FACS. METHODS: A participatory model was utilised; a questionnaire was developed and distributed to FACS-affected families via the Foetal Anticonvulsant Syndrome New Zealand (FACS NZ) organisation...
July 21, 2023: New Zealand Medical Journal
https://read.qxmd.com/read/37485793/prescribing-of-valproate-and-oral-antiepileptics-for-women-of-childbearing-age-and-during-pregnancy-in-germany-between-2010-and-2020
#32
JOURNAL ARTICLE
Katrin Scholz, Ingrid Köster, Ingo Meyer, Gisbert W Selke, Ingrid Schubert
PURPOSE: To examine prescriptions of valproate and oral antiepileptic drugs (OAED) in Germany irrespective of the indication in women in general and particularly in women of childbearing age (13-49 years) and during pregnancy between 2010 and 2020, that is, before, during and after the implementation of the EU risk minimization measures (RMMs). METHODS: Analysis of claims data. STUDY POPULATION: all women continuously insured with the AOK health insurance fund in the respective observation year (2010-2020) and the previous year...
July 23, 2023: Pharmacoepidemiology and Drug Safety
https://read.qxmd.com/read/37483432/valproate-pregnancy-prevention-scheme-what-are-the-barriers-to-enrolling-patients-and-how-do-we-meet-them
#33
JOURNAL ARTICLE
Musa Mamman Watila, Alistair James, Karen Milne, Graham Mackay
BACKGROUND: The UK Medicines Health products Regulation Agency instructs that valproate prescriptions should be restricted in women of childbearing age to those consenting to the Pregnancy Prevention Programme (PPP). We assessed the compliance and barriers to the valproate PPP. METHODS: We retrospectively audited NHS Grampian's compliance with PPP guidelines among women of childbearing potential prescribed valproate between October 2017 and March 2018. Additionally, we prospectively reviewed new valproate prescriptions from February 2019 to March 2022 and compared this with our retrospective data to assess the effectiveness of our identification process using descriptive statistics...
2023: BMJ neurology open
https://read.qxmd.com/read/37416806/retracted-analysis-of-the-clinical-effects-of-sodium-valproate-and-levetiracetam-in-the-treatment-of-women-with-epilepsy-during-pregnancy
#34
Evidence-Based Complementary And Alternative Medicine
[This retracts the article DOI: 10.1155/2021/5962200.].
2023: Evidence-based Complementary and Alternative Medicine: ECAM
https://read.qxmd.com/read/37407266/utilization-of-antiseizure-medications-in-women-of-childbearing-age-with-epilepsy-and-nonepilepsy-indications-a-retrospective-cohort-study
#35
JOURNAL ARTICLE
Oluwadolapo D Lawal, Kimford J Meador, Anne L Hume, Xuerong Wen
BACKGROUND AND OBJECTIVES: Antiseizure medications (ASMs) are among the most commonly prescribed teratogenic drugs in women of childbearing age. Limited data exist on utilization patterns across different indications for therapy and for the newer-generation ASMs in this population. Thus, we assessed the pattern of ASM use in women of childbearing age with epilepsy and nonepilepsy indications (pain and psychiatric disorders). METHODS: We conducted a retrospective analysis of deidentified administrative data submitted to the Optum Clinformatics database...
September 5, 2023: Neurology
https://read.qxmd.com/read/37361715/variation-in-prognosis-and-treatment-outcome-in-juvenile-myoclonic-epilepsy-a-biology-of-juvenile-myoclonic-epilepsy-consortium-proposal-for-a-practical-definition-and-stratified-medicine-classifications
#36
REVIEW
Guido Rubboli, Christoph P Beier, Kaja K Selmer, Marte Syvertsen, Amy Shakeshaft, Amber Collingwood, Anna Hall, Danielle M Andrade, Choong Yi Fong, Joanna Gesche, David A Greenberg, Khalid Hamandi, Kheng Seang Lim, Ching Ching Ng, Alessandro Orsini, Pasquale Striano, Rhys H Thomas, Jana Zarubova, Mark P Richardson, Lisa J Strug, Deb K Pal
Reliable definitions, classifications and prognostic models are the cornerstones of stratified medicine, but none of the current classifications systems in epilepsy address prognostic or outcome issues. Although heterogeneity is widely acknowledged within epilepsy syndromes, the significance of variation in electroclinical features, comorbidities and treatment response, as they relate to diagnostic and prognostic purposes, has not been explored. In this paper, we aim to provide an evidence-based definition of juvenile myoclonic epilepsy showing that with a predefined and limited set of mandatory features, variation in juvenile myoclonic epilepsy phenotype can be exploited for prognostic purposes...
2023: Brain communications
https://read.qxmd.com/read/37353789/youtube-as-a-source-of-information-on-preventing-the-use-of-valproic-acid-in-women-during-pregnancy
#37
JOURNAL ARTICLE
Boyang Qu, Binbin Kang, Xingyang Chen, Yanrong Ao, Liping Wang, Weiwei Cui
BACKGROUND: YouTube™ ( https://www.youtube.com ), as a very popular video site worldwide, is increasingly being used as a platform to disseminate health information. The purposes of this review were to assess the overall usefulness of the information on the prevention of valproic acid use in women during pregnancy on YouTube™ for patients. METHODS: The YouTube™ website was systematically using 8 keywords. One hundred and fifty four videos meet the selection criteria...
June 23, 2023: BMC Public Health
https://read.qxmd.com/read/37325172/a-case-report-and-a-brief-literature-review-of-belly-dancer-s-dyskinesia-in-a-pregnant-patient
#38
Abenet Tafesse Mengesha, Surafel Tilahun Maru, Mohammadjavad Ashrafi Mahabadi, Matyas Adugna Abebe, Berhanu Moges Abera, Ehsan Derafsh
Belly dancer's dyskinesia is a rare movement disorder that can be classified under hyperkinetic movement disorders. It is characterized by rhythmic or semi-rhythmic contractions of the diaphragm and other abdominal muscles that are brief and involuntary that cannot be voluntarily suppressed but could be influenced by respiratory maneuvers. Belly dancer's dyskinesia in pregnancy even rarer, there have only been five reported cases. Here, we reported 19-year-old Ethiopian pregnant women who presented with oscillating movements of the abdomen that occurred at her ninth month of pregnancy...
2023: SAGE Open Medical Case Reports
https://read.qxmd.com/read/37283266/prescribing-trends-of%C3%A2-antiseizure-drugs-in%C3%A2-women-veterans-with-epilepsy
#39
JOURNAL ARTICLE
Maria Raquel Lopez, Anne C VanCott, Megan E Amuan, Samin Panahi, Amy Henion, Mary Jo Pugh
OBJECTIVE: Antiseizure medications (ASMs) are frequently used for other indications, such as migraine, pain syndromes, and psychiatric disorders. Possible teratogenic effects are therefore of wide concern and the risks imposed by the medications must be weighed against the risk with the disorder treated. It is our objective to update family practitioners on the implications of starting ASM for women with epilepsy during childbearing age. We hypothesized that clinicians would prescribe ASM based on avoiding teratogenesis and treating associated comorbidities simultaneously...
June 6, 2023: Military Medicine
https://read.qxmd.com/read/37229383/comparison-of-the-probability-of-four-anticonvulsant-mood-stabilizers-to-facilitate-polycystic-ovary-syndrome-in-women-with-epilepsies-or-bipolar-disorder-a-systematic-review-and-meta-analysis
#40
Jing Guo, Yan Liu, Lingling Kong, Yaoyao Sun, Zhe Lu, Tianlan Lu, Haiying Qu, Weihua Yue
BACKGROUND: Patients treated with anticonvulsant mood stabilizers have a higher incidence of polycystic ovary syndrome (PCOS). However, there is no comparison between different anticonvulsant mood stabilizers. The purpose of this study was to systematically evaluate the prevalence of PCOS in women taking anticonvulsant mood stabilizers and compare the probability of PCOS caused by different anticonvulsant mood stabilizers. METHODS: Five databases, namely PubMed, Embase, Web of Science, Cochrane Library, and Clinical Trials, were searched for literature on anticonvulsant mood stabilizers and PCOS published up to October 28, 2022...
2023: Frontiers in Psychiatry
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