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https://www.readbyqxmd.com/read/29778017/the-preconception-care-experiences-of-women-with-epilepsy-on-sodium-valproate
#1
Lorna Lawther, Helen Dolk, Marlene Sinclair, Jim Morrow
PURPOSE: To understand the preconception experiences of women with epilepsy who have been taking the teratogenic drug valproate. METHODS: Seven women were recruited, three from a preconception clinic and four from an antenatal clinic in a region of the UK. All had taken valproate preconceptionally. Three preconception clinic encounters were observed and audio-recorded. Interviews with all women were analysed using Interpretative Phenomenological Analysis (IPA). RESULTS: Women experienced a "trajectory of balance"...
May 16, 2018: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29758362/the-anti-epileptic-drugs-valproate-carbamazepine-and-levetiracetam-cause-bone-loss-and-modulate-wnt-inhibitors-in-normal-and-ovariectomised-rats
#2
Bushra Parveen, Ambrish Kumar Tiwari, Moon Jain, Subhashis Pal, Naibedya Chattopadhyay, Manjari Tripathi, Divya Vohora
Secondary osteoporosis is the major concern associated with long term intake of antiepileptic drugs (AEDs). Women are the vulnerable targets owing to post-menopausal bone loss. In the present work, we evaluated the effect of 10 weeks of treatment with AED therapy (carbamazepine, CBZ, 75 mg/kg; sodium valproate, SVP, 300 mg/kg; levetiracetam, LTM, 150 mg/kg) on bone mineral density and microarchitecture at femoral epiphysis, lumbar vertebrae and proximal tibia of normal and ovariectomised Wistar rats...
May 11, 2018: Bone
https://www.readbyqxmd.com/read/29753923/prevalence-of-valproate-syndrome-in-europe-from-2005-to-2014-a-registry-based-multi-centre-study
#3
Joan K Morris, Ester Garne, Maria Loane, Marie-Claude Addor, Ingeborg Barisic, Fabrizio Bianchi, Miriam Gatt, Monica Lanzoni, Catherine Lynch, Olatz Mokoroa, Vera Nelen, Amanda Neville, Mary T O'Mahony, Hanitra Randrianaivo-Ranjatoelina, Anke Rissmann, David Tucker, H E K de Walle, Nataliia Zymak-Zakutnia, Judith Ankin
Women with epilepsy need to continue to take anticonvulsants during their pregnancies to prevent seizures from occurring. Since the 1980's, it has been known that the use of valproate (an anticonvulsant) in the first trimester of pregnancy is associated with an increased risk of spina bifida. Recent studies have also demonstrated increased risks of other congenital anomalies as well as a risk of cognitive impairment. Doctors in the EU are now advised not to prescribe valproate in pregnant women, in women who can become pregnant or in girls unless other treatments are ineffective or not tolerated...
May 10, 2018: European Journal of Medical Genetics
https://www.readbyqxmd.com/read/29730500/changes-in-antiepileptic-drug-prescribing-patterns-in-pregnant-women-with-epilepsy
#4
Kimford J Meador, Page B Pennell, Ryan C May, Elizabeth Gerard, Laura Kalayjian, Naymee Velez-Ruiz, Patricia Penovich, Jennifer Cavitt, Jaqueline French, Sean Hwang, Alison M Pack, Maria Sam, Eugene Moore, Dominic M Ippolito
OBJECTIVE: We analyzed current prescribing patterns for antiepileptic drugs (AEDs) in pregnant women with epilepsy (PWWE) at 20 USA tertiary epilepsy centers. METHODS: The Maternal Outcomes and Neurodevelopmental Effects of Antiepileptic Drugs (MONEAD) study is an NIH-funded, prospective, observational, multicenter investigation of pregnancy outcomes for both mother and child, which enrolled women from December 2012 to January 2016. Inclusion criteria for PWWE included ages 14-45 years and up to 20 weeks gestational age...
May 3, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29719929/the-effect-of-parity-on-risk-of-complications-in-pregnant-women-with-epilepsy-a-population-based-cohort-study
#5
Kim C Danielsson, Ingrid Borthen, Nils E Gilhus, Nils H Morken
INTRODUCTION: Women with epilepsy have increased risk of complications in pregnancy with consequences for the mother and child. There are no studies on the influence of parity on complications in women with epilepsy. MATERIAL AND METHODS: This was a population-based cohort study of all first and second births in the Medical Birth Registry of Norway 1999-2013. Risks were estimated and complication rates were compared in distinct women with epilepsy treatment categories...
May 2, 2018: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/29706306/psychiatric-comedication-in-patients-with-epilepsy
#6
Magdalena Bosak, Katarzyna Cyranka, Dominika Dudek, Monika Kowalik, Patrycja Mołek, Agnieszka Słowik
Psychiatric disorders are more common in patients with epilepsy than in the general population. The aims of the study were to assess the frequency and type of psychotropic drug usage in patients with epilepsy, to assess the risk factors for their use, and to assess their proconvulsive potential and the risk of interactions with antiepileptic drugs. This 20-month prospective study included patients treated at the university hospital outpatient clinic. Psychotropic drugs have been classified according to the Anatomical Therapeutic Chemical Classification System...
April 26, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29695479/mhra-bans-valproate-prescribing-for-women-not-in-pregnancy-prevention-programme
#7
Gareth Iacobucci
No abstract text is available yet for this article.
April 25, 2018: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29691249/hypertensive-pregnancy-complications-in-women-with-epilepsy-and-antiepileptic-drugs-a-population-based-cohort-study-of-first-pregnancies-in-norway
#8
Kim Christian Danielsson, Ingrid Borthen, Nils-Halvdan Morken, Nils Erik Gilhus
OBJECTIVES: To estimate the risk of hypertensive pregnancy complications in women with epilepsy, with and without antiepileptic drugs, and assess the risk associated with the four most common antiepileptic drugs. DESIGN: A population-based cohort study using linked data from the Medical Birth Registry of Norway and the Norwegian Prescription Database. Women with epilepsy with and without antiepileptic drugs were compared with women without epilepsy. SETTING: Norway, 2004-2012...
April 24, 2018: BMJ Open
https://www.readbyqxmd.com/read/29686037/women-and-valproate-what-should-neurologists-do
#9
John J Craig
No abstract text is available yet for this article.
April 23, 2018: Practical Neurology
https://www.readbyqxmd.com/read/29686036/valproate-and-epilepsy-for-women-as-well-as-men
#10
Charlotte Lawthom
Sodium valproate remains the best drug for idiopathic generalised epilepsy. For men with the latter diagnosis, this is the drug of choice. Sodium valproate has an unacceptably high level of major fetal malformation and also causes learning disabilities in many children exposed to the drug in utero. Women of reproductive age should not normally be offered this drug. There are many women with refractory epilepsy who would benefit from this drug and who are not planning pregnancy. Individualised epilepsy care is the gold standard, not blanket bans on drug choice based on gender...
April 23, 2018: Practical Neurology
https://www.readbyqxmd.com/read/29680205/comparative-risk-of-major-congenital-malformations-with-eight-different-antiepileptic-drugs-a-prospective-cohort-study-of-the-eurap-registry
#11
Torbjörn Tomson, Dina Battino, Erminio Bonizzoni, John Craig, Dick Lindhout, Emilio Perucca, Anne Sabers, Sanjeev V Thomas, Frank Vajda
BACKGROUND: Evidence for the comparative teratogenic risk of antiepileptic drugs is insufficient, particularly in relation to the dosage used. Therefore, we aimed to compare the occurrence of major congenital malformations following prenatal exposure to the eight most commonly used antiepileptic drugs in monotherapy. METHODS: We did a longitudinal, prospective cohort study based on the EURAP international registry. We included data from pregnancies in women who were exposed to antiepileptic drug monotherapy at conception, prospectively identified from 42 countries contributing to EURAP...
April 18, 2018: Lancet Neurology
https://www.readbyqxmd.com/read/29669717/weighing-the-risks-of-valproate-in-women-who-could-become-pregnant
#12
Heather Angus-Leppan, Rebecca S N Liu
No abstract text is available yet for this article.
April 18, 2018: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29661925/changing-antiepilepsy-drug-prescribing-trends-in-women-with-epilepsy-in-the-uk-and-ireland-and-the-impact-on-major-congenital-malformations
#13
Michael O Kinney, James Morrow, Chris C Patterson, Ellen Campbell, Aline Russell, Henry W Smithson, Linda Parsons, Patrick J Morrison, Rebecca Bromley, Brenda Liggan, Norman Delanty, Beth Irwin, Stephen J Hunt, John J Craig
OBJECTIVES: After 20 years of data collection, pregnancy registers have informed prescribing practice. Various populations show trends for a reduction in valproate prescribing, which is associated with an increased risk of anatomical teratogenesis and neurodevelopmental effects in those exposed in utero. Our aim was to determine if any shifts in prescribing trends have occurred in the UK and Ireland Epilepsy and Pregnancy Register cohort and to assess if there had been any change in the overall major congenital malformation (MCM) rate over time...
April 16, 2018: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/29601407/effect-of-valproate-and-antidepressant-drugs-on-clozapine-metabolism-in-patients-with-psychotic-mood-disorders
#14
Donatella Marazziti, Lionella Palego, Laura Betti, Gino Giannaccini, Enrico Massimetti, Stefano Baroni, Antonio Ciapparelli, Antonio Lucacchini, Federico Mucci, Liliana Dell'Osso
BACKGROUND: The aim of the present study was to appraise retrospectively the influence of valproate (VPA) and antidepressants (ADs) on the steady-state plasma concentrations of clozapine (CLZ), the prototype of various second-generation antipsychotics (SGAs), norclozapine (NCLZ, its main metabolite), and their ratio (NCLZ/CLZ). METHODS: Sixty-seven psychotic patients with a prevalent diagnosis of bipolar disorder (BD) were studied. We then analyzed data altogether and subdivided them into four groups, according to pharmacological treatments: #1 CLZ (n=21), #2 CLZ plus antidepressants (ADs) (n=13), #3 CLZ plus VPA (n=16), and #4 CLZ plus ADs plus VPA (n=17)...
March 29, 2018: Therapeutic Drug Monitoring
https://www.readbyqxmd.com/read/29588327/educational-attainment-of-children-born-to-mothers-with-epilepsy
#15
Arron S Lacey, William Owen Pickrell, Rhys H Thomas, Mike P Kerr, Cathy P White, Mark I Rees
OBJECTIVE: Small prospective studies have identified that children exposed to valproate in utero have poorer scores on cognitive testing. We wanted to identify whether children exposed to antiepileptic drugs (AEDs) in utero have poorer school performance. METHODS: We used anonymised, linked, routinely collected healthcare records to identify children born to mothers with epilepsy. We linked these children to their national attainment Key Stage 1 (KS1) tests in mathematics, language and science at the age of 7 and compared them with matched children born to mothers without epilepsy, and with the national KS1 results...
March 27, 2018: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/29526424/-specific-aspects-of-the-management-of-women-with-epilepsy
#16
REVIEW
Sophie Dupont
Catamenial epilepsy, defined as the exacerbation of the frequency of seizures in a given phase of the menstrual cycle, affects 35% of women. In women with catamenial epilepsy with perimenstrual seizures, progesterone therapy may be effective. In case of enzyme inducer AEDs, hormonal contraception is deprecated (estroprogestative or progestative pill, progestative implant, patches or hormonal rings). Because of its high malformative teratogenic potential, its possible depressive cognitive effects and the autistic risk, sodium valproate is not indicated during pregnancy...
March 2018: La Presse Médicale
https://www.readbyqxmd.com/read/29509301/declining-trend-in-valproate-use-in-finland-among-females-of-childbearing-age-in-2012-2016-a-nationwide-registry-based-outpatient-study
#17
L J Virta, R Kälviäinen, K Villikka, T Keränen
BACKGROUND AND PURPOSE: Documented teratogenic effects of valproate (VPA) prompted restrictions of its use in females of childbearing age in 2014. We investigated possible annual changes in the outpatient use of VPA in Finland during 2008-2016 with a special focus on women. METHODS: We identified all outpatients with VPA purchases between 2008 and 2016 categorizing users due to epilepsy, bipolar disorder or miscellaneous indications. Temporal trends in the annual prevalence rates of VPA use were estimated using Poisson regression analyses...
June 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29504704/a-cross-sectional-study-to-assess-the-modulation-of-wnt-inhibitors-following-anti-epileptic-drug-therapy-and-their-correlation-with-vitamin-d-and-receptor-activator-of-nuclear-factor-%C3%AE%C2%BA-b-ligand-in-indian-women-with-epilepsy
#18
Bushra Parveen, Manjari Tripathi, Divya Vohora
Long-term anti-epileptic drug (AED) therapy compromises bone health. Although vitamin D deficiency is proposed to be involved, it alone is not held responsible. This accounts for investigating other mechanisms in bone accrual. Recent studies have shown modulation of inhibitors of wnt pathway, sclerostin and dickkopf-1 (DKK-1), in glucocorticoids-induced osteoporosis. We investigated whether AED monotherapy modulates wnt inhibitors in Indian women with epilepsy. Women of age > 20-40 years with the diagnosis of epilepsy and receiving AEDs (carbamazepine, valproate and levetiracetam) for at least a year were enrolled...
March 5, 2018: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/29487964/-use-of-antiepileptic-drugs-during-breastfeeding-what-do-we-tell-the-mother
#19
M Crettenand, A O Rossetti, T Buclin, U Winterfeld
BACKGROUND: Knowledge about the passage of various antiepileptic drugs into breast milk and its consequences for the infant is limited. Faced with this uncertainty, breastfeeding is often discouraged for these patients. The aim of this study was to comprehensively review the available data regarding antiepileptic drugs during breastfeeding, to compare these data with information provided by the summary of product characteristics (SmPCs), and to provide recommendations for the use of these drugs in breastfeeding women...
February 27, 2018: Der Nervenarzt
https://www.readbyqxmd.com/read/29471258/outcomes-of-pregnancies-in-women-taking-antiepileptic-drugs-for-non-epilepsy-indications
#20
Dana Jazayeri, Janet Graham, Alison Hitchcock, Terence J O'Brien, Frank J E Vajda
PURPOSE: Antiepileptic drugs (AEDs), particularly valproate (VPA), are known to be teratogens when taken by women with epilepsy (WWE), but the risk in women who take these drugs for indications other than epilepsy have been little studied. This study aims to investigate the incidence of birth defects in children born to mothers taking AEDs for non-epilepsy indications. METHODS: The Australian Pregnancy Register (APR), established in 1998, is a prospective observational study operating with ethical approval and informed written consent for participation...
March 2018: Seizure: the Journal of the British Epilepsy Association
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