Guido Claessen, Ruben De Bosscher, Kristel Janssens, Paul Young, Christophe Dausin, Mathias Claeys, Piet Claus, Kaatje Goetschalckx, Jan Bogaert, Amy M Mitchell, Michael D Flannery, Adrian D Elliott, Chenglong Yu, Olivier Ghekiere, Tomas Robyns, Caroline M Van De Heyning, Prashanthan Sanders, Jonathan M Kalman, Monique Ohanian, Magdalena Soka, Emma Rath, Eleni Giannoulatou, Renee Johnson, Paul Lacaze, Lieven Herbots, Rik Willems, Diane Fatkin, Hein Heidbuchel, André La Gerche
BACKGROUND: Exercise-induced cardiac remodeling can be profound, resulting in clinical overlap with dilated cardiomyopathy, yet the significance of reduced ejection fraction (EF) in athletes is unclear. The aim is to assess the prevalence, clinical consequences, and genetic predisposition of reduced EF in athletes. METHODS: Young endurance athletes were recruited from elite training programs and underwent cardiac phenotyping, genetic analyses and clinical events were recorded over a mean of 4...
December 18, 2023: Circulation