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Franca Castiglione, Ameriga Lazzarini, Lucia Carrano, Emiliana Corti, Ismaela Ciciliato, Luciano Gastaldo, Paolo Candiani, Daniele Losi, Flavia Marinelli, Enrico Selva, Francesco Parenti
Antibiotics blocking bacterial cell wall assembly (beta-lactams and glycopeptides) are facing a challenge from the progressive spread of resistant pathogens. Lantibiotics are promising candidates to alleviate this problem. Microbisporicin, the most potent antibacterial among known comparable lantibiotics, was discovered during a screening applied to uncommon actinomycetes. It is produced by Microbispora sp. as two similarly active and structurally related polypeptides (A1, 2246-Da and A2, 2230-Da) of 24 amino acids linked by 5 intramolecular thioether bridges...
January 2008: Chemistry & Biology
Anton Kebis, Marián Kukan, Peter Grancic, Ján Jakubovský
BACKGROUND/AIM: Currently, the liver is cold-preserved at 0 approximately 4 degrees C for experimental and clinical purposes. Here, we investigated whether milder hypothermia during the initial phase of the preservation period was beneficial for liver viability upon reperfusion. METHODS: In the first set of experiments, rat livers were preserved either conventionally in clinically used histidine-trypthopan-ketoglutarate (HTK) solution (Group A: 45 min and Group B: 24 h) or by slow cooling HTK solution (from 13 degrees C to 3 degrees C) during the initial 45 min of preservation (Group C: 24 h)...
May 2007: Journal of Zhejiang University. Science. B
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