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Sox 11 lymphoma

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https://www.readbyqxmd.com/read/27720733/reproducibility-of-sox-11-detection-in-decalcified-bone-marrow-tissue-in-mantle-cell-lymphoma-patients
#1
Simona Righi, Stefano Pileri, Claudio Agostinelli, Francesco Bacci, Sebastiano Spagnolo, Elena Sabattini
Mantle cell lymphoma (MCL) usually harbor the t(11;14)(q13;q32) with overexpression of CCND1 mRNA and transcription of the cyclin D1 nuclear protein. Regardless CCND1 status, most MCLs also express the SOX11 nuclear protein, which is thus helpful in the diagnosis of the rare CCND1 negative MCLs. Recently, SOX11 has been reported to be often negative in MCLs clinically resembling marginal zone lymphoma and recently defined as "leukemic non-nodal" MCL in the incoming revision of the WHO Classification of lymphoid tumors, for which the bone marrow biopsy is commonly the first diagnostic approach...
October 5, 2016: Human Pathology
https://www.readbyqxmd.com/read/27539965/cutaneous-mantle-cell-lymphoma-a-clinicopathologic-review-of-10-cases
#2
Alejandro A Gru, M Yadira Hurley, Andrea L Salavaggione, Lindsey Brodell, David Sheinbein, Milan Anadkat, Pierluigi Porcu, John L Frater
Cutaneous mantle cell lymphoma (MCL) is exceedingly rare, almost always occurring as a dissemination of systemic MCL. To date, only 32 cases have been described. We report a series of 10 cases of MCL in the skin, and provide a comprehensive clinicopathologic review with clinical follow-up. Our cases occurred in older individuals (mean age = 70) and were more frequently in men (90%). Half of them presented in the head and neck region as a mass/nodule, and the remainder in the trunk and extremities as nodules...
December 2016: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/26103436/mantle-cell-lymphoma-2015-update-on-diagnosis-risk-stratification-and-clinical-management
#3
REVIEW
Julie M Vose
DISEASE OVERVIEW: Mantle cell lymphoma (MCL) is a non-Hodgkin lymphoma characterized by involvement of the lymph nodes, spleen, blood and bone marrow with a short remission duration to standard therapies and a median overall survival (OS) of 4-5 years. DIAGNOSIS: Diagnosis is based on lymph node, bone marrow, or tissue morphology of centrocytic lymphocytes, small cell type, or blastoid variant cells. A chromosomal translocation t (11:14) is the molecular hallmark of MCL, resulting in the overexpression of cyclin D1...
August 2015: American Journal of Hematology
https://www.readbyqxmd.com/read/24857884/do-mantle-cell-lymphomas-have-an-achilles-heel
#4
REVIEW
Nakhle Saba, Adrian Wiestner
PURPOSE OF REVIEW: Mantle cell lymphoma (MCL) is a mature B-cell malignancy that continues to have a high mortality rate. In this article, we discuss key pathogenic pathways in MCL biology and their possible therapeutic targeting. RECENT FINDINGS: In addition to cyclin-D1, the transcription factor SOX-11 emerged as a common characteristic of MCL. Genomic studies have identified a number of recurrently mutated genes; in order of descending frequency these include ATM, CCND1, UBR5, TP53, BIRC3, NOTCH1/2 and TRAF2...
July 2014: Current Opinion in Hematology
https://www.readbyqxmd.com/read/24273091/mantle-cell-lymphoma-2013-update-on-diagnosis-risk-stratification-and-clinical-management
#5
REVIEW
Julie M Vose
DISEASE OVERVIEW: Mantle cell lymphoma (MCL) is a non-Hodgkin lymphoma characterized by involvement of the lymph nodes, spleen, blood, and bone marrow with a short remission duration to standard therapies and a median overall survival of 4-5 years. DIAGNOSIS: Diagnosis is based on lymph node, bone marrow, or tissue morphology of centrocytic lymphocytes, small cell type, or blastoid variant cells. A chromosomal translocation t(11:14) is the molecular hallmark of MCL, resulting in the overexpression of cyclin D1...
December 2013: American Journal of Hematology
https://www.readbyqxmd.com/read/22615102/mantle-cell-lymphoma-2012-update-on-diagnosis-risk-stratification-and-clinical-management
#6
REVIEW
Julie M Vose
DISEASE OVERVIEW: Mantle cell lymphoma (MCL) is a non-Hodgkin lymphoma characterized by involvement of the lymph nodes, spleen, blood, and bone marrow with a short remission duration to standard therapies and a median overall survival of 4-5 years. DIAGNOSIS: Diagnosis is based on lymph node, bone marrow, or tissue morphology of centrocytic lymphocytes, small cell type, or blastoid variant cells. A chromosomal translocation t(11:14) is the molecular hallmark of MCL, resulting in the overexpression of cyclin D1...
June 2012: American Journal of Hematology
https://www.readbyqxmd.com/read/21124928/gene-expression-profiling-and-chromatin-immunoprecipitation-identify-dbn1-setmar-and-hig2-as-direct-targets-of-sox11-in-mantle-cell-lymphoma
#7
Xiao Wang, Stefan Björklund, Agata M Wasik, Alf Grandien, Patrik Andersson, Eva Kimby, Karin Dahlman-Wright, Chunyan Zhao, Birger Christensson, Birgitta Sander
The SRY (sex determining region Y)-box 11 (SOX11) gene, located on chromosome 2p25, encodes for a transcription factor that is involved in tissue remodeling during embryogenesis and is crucial for neurogenesis. The role for SOX11 in hematopoiesis has not yet been defined. Two genes under direct control of SOX11 are the class- III β-tubulin gene (TUBB3) in neural cells and the transcription factor TEA domain family member 2 (TEAD2) in neural and mesenchymal progenitor cells. Normal, mature lymphocytes lack SOX11 but express SOX4, another member of the same group of SOX transcription factors...
2010: PloS One
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