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https://www.readbyqxmd.com/read/28445814/comprehensive-profiling-and-characterization-of-coumarins-from-roots-stems-leaves-branches-and-seeds-of-chimonanthus-nitensoliv-using-ultra-performance-liquid-chromatography-quadrupole-time-of-flight-mass-spectrometry-combined-with-modified-mass-defect-filter
#1
Ting Tan, Yun Luo, Chen-Cong Zhong, Xu Xu, Yulin Feng
Chimonanthus nitensOliv. (CNO), having been studied and developed as the tea beverages, tea raw materials and preparations, an unique species in China, have been extensively used for treating colds and influenza for centuries. In the present study, a method based on the modified mass defect filter (MDF) was firstly developed and validated for comprehensive profiling of coumarins in the different parts of CNO via ultra-performance liquid chromatography tandem quadrupole time-of-flight mass spectrometry (UPLC-QTOF/MS)...
April 17, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28410669/curcumin-and-linseed-oil-co-delivered-in-phospholipid-nanoemulsions-enhances-the-levels-of-docosahexaenoic-acid-in-serum-and-tissue-lipids-of-rats
#2
D Sugasini, B R Lokesh
Docosahexaenoic acid (DHA) is an important long chain omega-3 polyunsaturated fatty acid (PUFA) primarily found in marine fishes. The diets of vegetarian population do not contain preformed DHA, but they can derive it from shorter chain α-linolenic acid (ALA) found in plant oils. However, the conversion efficiency of ALA to DHA is minimal in human adults. This may cause insufficiency of DHA in the vegetarian population. Curcumin, diferuloyl methane found in the spice turmeric, has the potential to increase the formation of DHA from ALA by activating the enzymes FADS2 and elongase 2...
April 2017: Prostaglandins, Leukotrienes, and Essential Fatty Acids
https://www.readbyqxmd.com/read/28401420/an-update-on-the-pathogenesis-and-treatment-of-chronic-recurrent-multifocal-osteomyelitis-in-children
#3
Andrea Taddio, Floriana Zennaro, Serena Pastore, Rolando Cimaz
Chronic recurrent multifocal osteomyelitis (CRMO), also known as chronic non-bacterial osteomyelitis (CNO), is a rare inflammatory disorder that primarily affects children. It is characterized by pain, local bone expansion, and radiological findings suggestive of osteomyelitis, usually at multiple sites. CRMO predominantly affects the metaphyses of long bones, but involvement of the clavicle or mandible are suggestive of the diagnosis. CRMO is a diagnosis of exclusion, and its pathogenesis remains unknown. Differential diagnosis includes infection, malignancies, benign bone tumors, metabolic disorders, and other autoinflammatory disorders...
April 11, 2017: Paediatric Drugs
https://www.readbyqxmd.com/read/28386207/activation-of-the-ventral-tegmental-area-increased-wakefulness-in-mice
#4
Huan-Xin Sun, Dian-Ru Wang, Chen-Bo Ye, Zhen-Zhen Hu, Chen-Yao Wang, Zhi-Li Huang, Su-Rong Yang
The ventral tegmental area (VTA) is crucial for brain functions, such as voluntary movement and cognition; however, the role of VTA in sleep-wake regulation when directly activated or inhibited remains unknown. In this study, we investigated the effects of activation or inhibition of VTA neurons on sleep-wake behavior using the pharmacogenetic "designer receptors exclusively activated by designer drugs (DREADD)" approach. Immunohistochemistry staining was performed to confirm the microinjection sites, and combined with electrophysiological experiments, to determine whether the VTA neurons were activated or inhibited...
2017: Sleep and Biological Rhythms
https://www.readbyqxmd.com/read/28383527/activation-of-the-hypoglossal-to-tongue-musculature-motor-pathway-by-remote-control
#5
Garret A Horton, Jimmy J Fraigne, Zoltan A Torontali, Matthew B Snow, Jennifer L Lapierre, Hattie Liu, Gaspard Montandon, John H Peever, Richard L Horner
Reduced tongue muscle tone precipitates obstructive sleep apnea (OSA), and activation of the tongue musculature can lessen OSA. The hypoglossal motor nucleus (HMN) innervates the tongue muscles but there is no pharmacological agent currently able to selectively manipulate a channel (e.g., Kir2.4) that is highly restricted in its expression to cranial motor pools such as the HMN. To model the effect of manipulating such a restricted target, we introduced a "designer" receptor into the HMN and selectively modulated it with a "designer" drug...
April 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28378309/recycling-of-palm-oil-industrial-wastes-using-vermicomposting-technology-its-kinetics-study-and-environmental-application
#6
Parveen Fatemeh Rupani, Asha Embrandiri, Mahamad Hakimi Ibrahim, Mohammad Shahadat, Sune Balle Hansen, Sultan Ahmed Ismail, Mohd Omar Ab Kadir
The present paper reports management of palm oil mill effluent (POME) mixed with palm-pressed fibre (PPF) POME-PPF mixture using eco-friendly, cost-effective vermicomposting technology. Vermicomposting of POME-PPF was performed to examine the optimal POME-PPF ratio with respect to the criteria of earthworm biomass and to evaluate the decomposition of carbon and nitrogen in different percentages of POME-PPF mixtures. Chemical parameters such as TOC, N, P and K contents were determined to achieve optimal decomposition of POME-PPF...
April 4, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28370646/worst-pattern-of-invasion-and-occult-cervical-metastases-for-oral-squamous-carcinoma
#7
Claudia Velosa, Qiuying Shi, Todd M Stevens, Simion I Chiosea, Bibiana Purgina, William Carroll, Eben Rosenthal, Anthony Morlandt, Thom Loree, Margaret S Brandwein-Weber
BACKGROUND: The Risk Model is a validated prognostic schema for patients with oral cavity squamous carcinoma. Here, we examine the relationship between Worst Pattern of Invasion-type 5 (WPOI-5) and occult cervical metastases, and also present an interim observational analysis of the impact of adjuvant radiotherapy on patients with low-stage oral cancer classified as either high risk or WPOI-5 alone. METHODS: There were 323 patients with T1 T2 cNo oral cavity squamous carcinoma treated by primary resection, 152 of whom also underwent elective neck dissection (END)...
March 28, 2017: Head & Neck
https://www.readbyqxmd.com/read/28363838/orexin-activation-counteracts-decreases-in-nonexercise-activity-thermogenesis-neat-caused-by-high-fat-diet
#8
P E Bunney, A N Zink, A A Holm, C J Billington, C M Kotz
Overweight and obesity result from an imbalance between caloric intake and energy expenditure, including expenditure from spontaneous physical activity (SPA). Changes in SPA and resulting changes in non-exercise activity thermogenesis (NEAT) likely interact with diet to influence risk for obesity. However, previous research on the relationship between diet, physical activity, and energy expenditure has been mixed. The neuropeptide orexin is a driver of SPA, and orexin neuron activity can be manipulated using DREADDs (Designer Receptors Exclusively Activated by Designer Drugs)...
March 28, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/28357959/let-s-work-together-to-spread-good-practice
#9
(no author information available yet)
Hundreds of the country's most senior nurses and midwives met in Birmingham last month at the annual summit of England's chief nursing officer (CNO). It proved to be a great opportunity to hear some of the most influential thinkers and speakers in healthcare, including the chief nurse herself, Jane Cummings.
March 30, 2017: Nursing Management (Harrow)
https://www.readbyqxmd.com/read/28357954/eu-nurses-need-our-support-says-cno
#10
(no author information available yet)
Nurses from the European Union (EU) face an 'uncertain future' and need our support, Jane Cummings said, as she opened her fifth chief nursing officer (CNO) for England's summit in Birmingham.
March 30, 2017: Nursing Management (Harrow)
https://www.readbyqxmd.com/read/28339126/boron-doped-polygonal-carbon-nano-onions-synthesis-and-applications-in-electrochemical-energy-storage
#11
Marta Eliza Plonska-Brzezinska, Olena Mykhailiv, Krzysztof Brzezinski, Bogdan Sulikowski, Zbigniew Olejniczak, Malgorzata Gras, Grzegorz Lota, Agustin Molina-Ontoria, Michal Jakubczyk, Luis Echegoyen
Doping of carbon nanostructures with heteroatoms, such as boron or nitrogen, is one of the most effective ways to change their properties to make them suitable for various applications. Carbon nano-onions (CNOs) doped with boron (B-CNOs) have been prepared by annealing (1650°C) nanodiamond particles (NDs) under an inert He atmosphere in the presence of B. Their physicochemical properties were measured using transmission (TEM) and scanning (SEM) electron microscopy, X-ray photoelectron spectroscopy (XPS), 10B and 11B solid-state MAS NMR spectroscopy, X-ray powder diffractions (XRD), Raman spectroscopy, porosimetry, and differential-thermogravimetric analyses (TGA-DTG)...
March 24, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28325790/dopamine-terminals-from-the-ventral-tegmental-area-gate-intrinsic-inhibition-in-the-prefrontal-cortex
#12
William C Buchta, Stephen V Mahler, Benjamin Harlan, Gary S Aston-Jones, Arthur C Riegel
Spike frequency adaptation (SFA or accommodation) and calcium-activated potassium channels that underlie after-hyperpolarization potentials (AHP) regulate repetitive firing of neurons. Precisely how neuromodulators such as dopamine from the ventral tegmental area (VTA) regulate SFA and AHP (together referred to as intrinsic inhibition) in the prefrontal cortex (PFC) remains unclear. Using whole cell electrophysiology, we measured intrinsic inhibition in prelimbic (PL) layer 5 pyramidal cells of male adult rats...
March 2017: Physiological Reports
https://www.readbyqxmd.com/read/28324647/metabolism-and-distribution-of-clozapine-n-oxide-implications-for-nonhuman-primate-chemogenetics
#13
Jessica Raper, J Scott Daniels, Ryan D Morrison, Leonard Howell, Jocelyne Bachevalier, Thomas Wichmann, Adriana Galvan
The use of Designer Receptors Exclusively Activated by Designer Drugs (DREADDs) in neuroscience has rapidly expanded in rodent studies, but has lagged behind in nonhuman primate (NHP) experiments, slowing the development of this method for therapeutic use in humans. One reason for the slow adoption of DREADD technology in primates is that the pharmacokinetic properties and bioavailability of clozapine-n-oxide (CNO), the most commonly used ligand for human muscarinic (hM) DREADDs, are not fully described in primates...
March 21, 2017: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/28322236/the-role-of-mesolimbic-reward-neurocircuitry-in-prevention-and-rescue-of-the-activity-based-anorexia-aba-phenotype-in-rats
#14
Claire J Foldi, Laura K Milton, Brian J Oldfield
Patients suffering anorexia nervosa (AN) become anhedonic; unable or unwilling to derive normal pleasures and avoid rewarding outcomes, most profoundly in food intake. The activity-based anorexia (ABA) model recapitulates many of the characteristics of the human condition, including anhedonia, and allows investigation of the underlying neurobiology of AN. The potential for increased neuronal activity in reward/hedonic circuits to prevent and rescue weight loss is investigated in this model. The mesolimbic pathway extending from the ventral tegmental area (VTA) to the nucleus accumbens (NAc) was activated using a dual viral strategy, involving retrograde transport of Cre (CAV2-Cre) to the VTA and coincident injection of DREADD receptors (AAV-hSyn-DIO-hM3D(Gq)-mCherry)...
March 21, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28281681/chemogenetic-stimulation-of-the-hypoglossal-neurons-improves-upper-airway-patency
#15
Thomaz Fleury Curado, Kenneth Fishbein, Huy Pho, Michael Brennick, Olga Dergacheva, Luiz U Sennes, Luu V Pham, Ellen E Ladenheim, Richard Spencer, David Mendelowitz, Alan R Schwartz, Vsevolod Y Polotsky
Obstructive sleep apnea (OSA) is characterized by recurrent upper airway obstruction during sleep. OSA leads to high cardiovascular morbidity and mortality. The pathogenesis of OSA has been linked to a defect in neuromuscular control of the pharynx. There is no effective pharmacotherapy for OSA. The objective of this study was to determine whether upper airway patency can be improved using chemogenetic approach by deploying designer receptors exclusively activated by designer drug (DREADD) in the hypoglossal motorneurons...
March 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28279113/chief-nursing-officer-and-rcn-launch-project-to-inspire-the-next-generation
#16
(no author information available yet)
England's chief nursing officer (CNO) is to embark on a project to improve the image of nursing.
March 10, 2017: Emergency Nurse: the Journal of the RCN Accident and Emergency Nursing Association
https://www.readbyqxmd.com/read/28247821/chief-nurse-pledges-to-improve-image-of-nursing
#17
Stephanie Jones-Berry
England's chief nursing officer (CNO) is to embark on a project to improve the image of nursing. Speaking exclusively to Nursing Standard, Jane Cummings outlined early plans for a joint initiative with the RCN.
March 1, 2017: Nursing Standard
https://www.readbyqxmd.com/read/28244163/chemogenetic-enhancement-of-functional-recovery-after-a-sciatic-nerve-injury
#18
Poonam B Jaiswal, Arthur W English
Designer receptors exclusively activated by designer drugs (DREADDs) are chemogenetic tools used to modulate neuronal excitability. We hypothesized that activation of excitatory (Gq) DREADD by its designer ligand, clozapine-N-oxide (CNO), would increase the excitability of neurons whose axons have been transected following peripheral nerve injury, and that this increase will lead to an enhanced functional recovery. The lateral gastrocnemius (LG) muscle of adult female Lewis rats was injected unilaterally with AAV9- hsyn- hM3Dq-mCherry (7...
February 28, 2017: European Journal of Neuroscience
https://www.readbyqxmd.com/read/28242912/oxidative-stability-thermal-stability-and-acceptability-of-coconut-oil-flavored-with-essential-oils-from-black-pepper-and-ginger
#19
Janu Chandran, N Nayana, N Roshini, P Nisha
The present study investigates the oxidative and thermal stability of flavoured oils developed by incorporating essential oils from black pepper and ginger to coconut oil (CNO) at concentrations of 0.1 and 1.0% (CNOP-0.1, CNOP-1, CNOG-0.1, CNOG-1). The stability of oils were assessed in terms of free fatty acids, peroxide, p-anisidine, conjugated diene and triene values and compared with CNO without any additives and a positive control with synthetic antioxidant TBHQ (CNOT). It was found that the stability of CNOP-1 and CNOG-1 were comparable with CNOT at both study conditions...
January 2017: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/28235898/gabaergic-neurons-of-the-central-amygdala-promote-cataplexy
#20
Carrie E Mahoney, Lindsay J Agostinelli, Jessica N K Brooks, Bradford B Lowell, Thomas E Scammell
Narcolepsy is characterized by chronic sleepiness and cataplexy-sudden muscle paralysis triggered by strong, positive emotions. This condition is caused by a lack of orexin (hypocretin) signaling, but little is known about the neural mechanisms that mediate cataplexy. The amygdala regulates responses to rewarding stimuli and contains neurons active during cataplexy. In addition, lesions of the amygdala reduce cataplexy. Because GABAergic neurons of the central nucleus of the amygdala (CeA) target brainstem regions known to regulate muscle tone, we hypothesized that these cells promote emotion-triggered cataplexy...
April 12, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
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