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https://www.readbyqxmd.com/read/29303143/cno-evil-considerations-for-the-use-of-dreadds-in-behavioral-neuroscience
#1
Stephen V Mahler, Gary Aston-Jones
Neuropsychopharmacology accepted article preview online, 05 January 2018. doi:10.1038/npp.2017.299.
January 5, 2018: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29296027/metabolic-mapping-of-downstream-network-activity-following-cno-induced-activation-of-hm3dq-in-bnst-vgat-neurons
#2
C M Mazzone, D Pati, M Michaelides, J DiBerto, J H Fox, G Tipton, C Anderson, K Duffy, J M McKlveen, J A Hardaway, S T Magness, W A Falls, S E Hammack, Z A McElligott, Y L Hurd, T L Kash
No abstract text is available yet for this article.
January 2018: Molecular Psychiatry
https://www.readbyqxmd.com/read/29287595/dealing-with-chronic-non-bacterial-osteomyelitis-a-practical-approach
#3
REVIEW
Andrea Taddio, Giovanna Ferrara, Antonella Insalaco, Manuela Pardeo, Massimo Gregori, Martina Finetti, Serena Pastore, Alberto Tommasini, Alessandro Ventura, Marco Gattorno
BACKGROUND: Chronic Non-Bacterial Osteomyelitis (CNO) is an inflammatory disorder that primarily affects children. Although underestimated, its incidence is rare. For these reasons, no diagnostic and no therapeutic guidelines exist. The manuscript wants to give some suggestions on how to deal with these patients in the every-day clinical practice. MAIN BODY: CNO is characterized by insidious onset of bone pain with local swelling. Systemic symptoms such as fever, skin involvement and arthritis may be sometimes present...
December 29, 2017: Pediatric Rheumatology Online Journal
https://www.readbyqxmd.com/read/29286739/direct-measurement-of-the-key-e_-c-m-456%C3%A2-%C3%A2-kev-resonance-in-the-astrophysical-19-ne-p-%C3%AE-20-na-reaction-and-its-relevance-for-explosive-binary-systems
#4
R Wilkinson, G Lotay, A Lennarz, C Ruiz, G Christian, C Akers, W N Catford, A A Chen, D Connolly, B Davids, D A Hutcheon, D Jedrejcic, A M Laird, L Martin, E McNeice, J Riley, M Williams
We have performed a direct measurement of the ^{19}Ne(p,γ)^{20}Na reaction in inverse kinematics using a beam of radioactive ^{19}Ne. The key astrophysical resonance in the ^{19}Ne+p system has been definitely measured for the first time at E_{c.m.}=456_{-2}^{+5}  keV with an associated strength of 17_{-5}^{+7}  meV. The present results are in agreement with resonance strength upper limits set by previous direct measurements, as well as resonance energies inferred from precision (^{3}He, t) charge exchange reactions...
December 15, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/29285895/hydrothermally-induced-o-doping-and-porous-structure-of-graphitic-carbon-nitride-with-highly-ordered-architecture-and-dramatically-enhanced-photocatalytic-property
#5
Chao Wang, Huiqing Fan, Xiaohu Ren, Jiangwei Ma, Jiawen Fang, Weijia Wang
As an amorphous or semi-crystalline material, graphitic carbon nitride (g-C3N4) displays poor photocatalytic activity due to the rapid recombination of photo generated charge carriers, which is mainly caused by the high density of defects in the graphitic structure. In this work, a porous O-doped g-C3N4 nanosheet (P-CNO) with highly ordered architecture is fabricated by introducing a novel hydrothermal treatment to the precursor before the final thermal condensation. The photocatalytic hydrogen evolution rate (HER) and HER per surface area of P-CNO are 13...
December 29, 2017: ChemSusChem
https://www.readbyqxmd.com/read/29282260/chronic-non-bacterial-osteitis-from-the-patient-perspective-a-health-services-research-through-data-collected-from-patient-conferences
#6
Colen Cooper Gore Silier, Justina Greschik, Susanne Gesell, Veit Grote, Annette F Jansson
OBJECTIVE: Although chronic non-bacterial osteitis (CNO) is an ever-increasingly recognised illness in the paediatric community and the adult healthcare community, a study to assess diagnosing, treatment and the psychosocial aspect of CNO from a large population pool was not available. We aimed to investigate CNO from the patient perspective. DESIGN: Health services research, patient survey. SETTING: Ludwig-Maximilians-University (LMU) Pediatric Rheumatology Department CNO Conferences held in June 2013 and June 2015...
December 26, 2017: BMJ Open
https://www.readbyqxmd.com/read/29250517/serum-interleukin-6-and-ccl11-eotaxin-may-be-suitable-biomarkers-for-the-diagnosis-of-chronic-nonbacterial-osteomyelitis
#7
Sigrun Ruth Hofmann, Fanny Böttger, Ursula Range, Christian Lück, Henner Morbach, Hermann Joseph Girschick, Meinolf Suttorp, Christian Michael Hedrich
Objectives: Chronic recurrent multifocal osteomyelitis (CRMO), the most severe form of chronic nonbacterial osteomyelitis (CNO), is an autoinflammatory bone disorder. In the absence of diagnostic criteria or biomarkers, CNO/CRMO remains a diagnosis of exclusion. The aim of this study was to identify biomarkers for diagnosing multifocal disease (CRMO). Study design: Sera from 71 pediatric CRMO patients, 11 patients with osteoarticular infections, 62 patients with juvenile idiopathic arthritis (JIA), 7 patients with para-infectious or reactive arthritis, and 43 patients with acute leukemia or lymphoma, as well as 59 healthy individuals were collected...
2017: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/29218003/eye-drops-for-activation-of-dreadds
#8
William T Keenan, Diego C Fernandez, Lukas J Shumway, Haiqing Zhao, Samer Hattar
Designer Receptors Exclusively Activated by Designer Drugs (DREADDs) are an important tool for modulating and understanding neural circuits. Depending on the DREADD system used, DREADD-targeted neurons can be activated or repressed in vivo following a dose of the DREADD agonist clozapine-N-oxide (CNO). Because DREADD experiments often involve behavioral assays, the method of CNO delivery is important. Currently, the most common delivery method is intraperitoneal (IP) injection. IP injection is both a fast and reliable technique, but it is painful and stressful particularly when many injections are required...
2017: Frontiers in Neural Circuits
https://www.readbyqxmd.com/read/29215950/preparation-and-characterization-of-alkaline-phosphatase-horseradish-peroxidase-and-glucose-oxidase-conjugates-with-carboxylated-carbon-nano-onions
#9
Vibol Sok, Alex Fragoso
Carbon nanomaterials have emerged as suitable supports for enzyme immobilization and stabilization due to their inherently large surface area, high electrical conductivity, chemical stability and mechanical strength. In this paper, carbon nano-onions (CNOs) were used as supports to immobilize alkaline phosphatase, horseradish peroxidase and glucose oxidase. CNOs were first functionalized by oxidation to generate carboxylic groups on the surface followed by the covalent linking of the using a soluble carbodiimide as coupling agent...
December 7, 2017: Preparative Biochemistry & Biotechnology
https://www.readbyqxmd.com/read/29194335/the-cno-and-leading-innovation-competencies-for-the-future
#10
Barbara Weatherford, Kathleen A Bower, Joan Vitello-Cicciu
Although innovation is critical to success in today's tumultuous environment, health care is slow to embrace it, and there is significant variability in strategic adoption of innovation across organizations. Nurse leaders do not need to be innovators themselves but must engage in, and have the ability to create, an organizational culture of innovation. Twenty-six leadership behaviors specific to innovation leadership were identified through a Delphi study to develop competencies as well as the knowledge, skills, and attitudes that support nurse leaders in acquiring or expanding the capability of nurse leaders to create a culture of innovation...
January 2018: Nursing Administration Quarterly
https://www.readbyqxmd.com/read/29180723/neuromodulation-of-orexin-neurons-reduces-diet-induced-adiposity
#11
A N Zink, P E Bunney, A A Holm, C J Billington, C M Kotz
BACKGROUND/OBJECTIVES: Low levels of orexin are associated with obesity and reduced physical activity in humans and animals. SUBJECTS/METHODS: Designer Receptors Exclusively Activated by Designer Drugs (DREADDs) selectively activated orexin neurons in mouse lateral hypothalamus (LH) to measure effects on spontaneous physical activity (SPA). DREADD targeting was achieved by stereotaxic injection of AAV vectors into caudal lateral LH of heterozygous orexin Cre or C57/B6J mice...
November 28, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29146932/activation-of-endogenous-arginine-vasopressin-neurons-inhibit-food-intake-by-using-a-novel-transgenic-rat-line-with-dreadds-system
#12
Mitsuhiro Yoshimura, Kazuaki Nishimura, Haruki Nishimura, Satomi Sonoda, Hiromichi Ueno, Yasuhito Motojima, Reiko Saito, Takashi Maruyama, Yuki Nonaka, Yoichi Ueta
Various studies contributed to discover novel mechanisms of central arginine vasopressin (AVP) system responsible for the behaviour albeit endogenous vasopressin activation. We established a novel transgenic rat line which expresses both human muscarinic acetylcholine receptors (hM3Dq), of which ligand is clozapine-N-oxide (CNO), and mCherry fluorescence specifically in AVP neurons. The mCherry neurons that indicate the expression of the hM3Dq gene were observed in the suprachiasmatic (SCN), supraoptic (SON), and paraventricular nuclei (PVN)...
November 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29143845/pulse-laser-induced-fragmentation-of-carbon-quantum-dots-a-structural-analysis
#13
Han-Wei Chu, Ju-Yi Mao, Chia-Wen Lien, Pang-Hung Hsu, Yu-Jia Li, Jui-Yang Lai, Tai-Chia Chiu, Chih-Ching Huang
Carbon quantum dots (CQDs) have attracted enormous interest in recent years owing to their low cytotoxicity, excellent biocompatibility and strong fluorescence. They have been successfully employed in sensor, bio-imaging, and drug carrier applications. A complete understanding of their core-surface structure is essential for tuning their physical and chemical properties for various applications. Conventional characterizations of CQDs are conducted with electron microscopy or spectroscopy, such as transmission electron microscopy, X-ray photoelectron spectroscopy, Fourier transform infrared spectroscopy and Raman spectroscopy...
November 16, 2017: Nanoscale
https://www.readbyqxmd.com/read/29112802/consensus-treatment-plans-for-chronic-nonbacterial-osteomyelitis-refractory-to-nonsteroidal-anti-inflammatory-drugs-and-or-with-active-spinal-lesions
#14
Yongdong Zhao, Eveline Y Wu, Melissa S Oliver, Ashley M Cooper, Matthew L Basiaga, Sheetal S Vora, Tzielan C Lee, Emily Fox, Gil Amarilyo, Sara M Stern, Jeffrey A Dvergsten, Kathleen A Haines, Kelly A Rouster-Stevens, Karen B Onel, Julie Cherian, Jonathan S Hausmann, Paivi Miettunen, Tania Cellucci, Farzana Nuruzzaman, Angela Taneja, Karyl S Barron, Matthew C Hollander, Sivia K Lapidus, Suzanne C Li, Seza Ozen, Hermann Girschick, Ronald M Laxer, Fatma Dedeoglu, Christian M Hedrich, Polly J Ferguson
OBJECTIVE: To develop standardized treatment regimens for chronic nonbacterial osteomyelitis (CNO), also known as chronic recurrent multifocal osteomyelitis (CRMO) to enable comparative effectiveness treatment studies. METHODS: Virtual and face-to-face discussions and meetings were held within the CNO subgroup of the Childhood Arthritis and Rheumatology Research Alliance (CARRA). A literature search was conducted, and CARRA membership was surveyed to evaluate available treatment data and identify current treatment practices...
November 7, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/29080202/chronic-recurrent-multifocal-osteomyelitis-crmo-presentation-pathogenesis-and-treatment
#15
REVIEW
Sigrun R Hofmann, Franz Kapplusch, Hermann J Girschick, Henner Morbach, Jessica Pablik, Polly J Ferguson, Christian M Hedrich
PURPOSE OF REVIEW: Chronic non-bacterial osteomyelitis (CNO) with its most severe form chronic recurrent multifocal osteomyelitis (CRMO) is an autoinflammatory bone disorder. We summarize the clinical presentation, diagnostic approaches, most recent advances in understanding the pathophysiology, and available treatment options and outcomes in CNO/CRMO. RECENT FINDINGS: Though the exact molecular pathophysiology of CNO/CRMO remains somewhat elusive, it appears likely that variable defects in the TLR4/MAPK/inflammasome signaling cascade result in an imbalance between pro- and anti-inflammatory cytokine expressions in monocytes from CNO/CRMO patients...
October 27, 2017: Current Osteoporosis Reports
https://www.readbyqxmd.com/read/29077837/selective-pharmacogenetic-activation-of-catecholamine-subgroups-in-the-ventrolateral-medulla-elicits-key-glucoregulatory-responses
#16
Ai-Jun Li, Qing Wang, Sue Ritter
Catecholamine (CA) neurons in the ventrolateral medulla (VLM) contribute importantly to glucoregulation during glucose deficit. However, it is not known which CA neurons elicit different glucoregulatory responses or whether selective activation of CA neurons is sufficient to elicit these responses. Therefore, to selectively activate CA subpopulations, we injected male or female Th-Cre+ transgenic rats with the Cre-dependent DREADD construct, AAV2-DIO-hSyn-hM3D(Gq)-mCherry, at one of 4 rostrocaudal levels of the VLM: rostral C1 (C1r), middle C1 (C1m), the area of A1 and C1 overlap (A1/C1) or A1...
October 24, 2017: Endocrinology
https://www.readbyqxmd.com/read/29074870/nonlinear-magnetoelectric-effect-in-paraelectric-state-of-co4nb2o9-single-crystal
#17
Yiming Cao, Guochu Deng, Přemysl Beran, Zhenjie Feng, Baojuan Kang, Jincang Zhang, Nicolas Guiblin, Brahim Dkhil, Wei Ren, Shixun Cao
We report the structural, magnetoelectric (ME), magnetic and electric control of magnetic properties in Co4Nb2O9 (CNO) single crystal. A detailed ME measurement reveals a nonlinear ME effect instead of a linear ME effect in CNO single crystal. By fitting the magnetization-electric field (M-E) curve, it can be found that the linear ([Formula: see text]) and quadratic (γ) coefficients equal to ~8.27 ps/m and ~-6.46 ps/MV for upper branch, as well as ~8.38 ps/m and ~6.75 ps/MV for the lower branch. More importantly, a pronounced response was observed under a small cooling magnetic field, which cannot even cause the spin flop...
October 26, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28956409/panorama-of-the-nursing-models-used-by-chief-nursing-officers-in-bilingual-and-french-speaking-belgian-hospitals
#18
Dan Lecocq, Hélène Lefebvre, Lucie Bachelet, Ouassinia Berrabah, David Dyikpanu, Daniel Martin, Damien Siddu, Yves Mengal, Magali Pirson
The use of a Nursing Model (NM) for nursing administration offers direct and indirect benefits for patients as for nurses. Depending the chosen NM, the concepts of person, health, nursing and environment are very different. Each NM has its special vision of the practice of nursing. The study investigated whether the Chief Nursing Officers (CNO) of the bilingual and French speaking Belgian hospitals integrate Nursing Models in the politics of their department. A quantitative descriptive and correlational survey was conducted...
August 17, 2017: Recherche en Soins Infirmiers
https://www.readbyqxmd.com/read/28944635/-unknown-title
#19
(no author information available yet)
The use of a Nursing Model (NM) for nursing administration offers direct and indirect benefits for patients as for nurses. Depending the chosen NM, the concepts of person, health, nursing and environment are very different. Each NM has its special vision of the practice of nursing. The study investigated whether the Chief Nursing Officers (CNO) of the bilingual and French speaking Belgian hospitals integrate Nursing Models in the politics of their department. A quantitative descriptive and correlational survey was conducted...
August 17, 2017: Recherche en Soins Infirmiers
https://www.readbyqxmd.com/read/28926549/chemical-methods-dreadds-see-no-cno
#20
Mirella Bucci
No abstract text is available yet for this article.
September 19, 2017: Nature Chemical Biology
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