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https://www.readbyqxmd.com/read/29325446/reduction-of-ptsd-symptoms-with-pre-reactivation-propranolol-therapy-a-randomized-controlled-trial
#1
Alain Brunet, Daniel Saumier, Aihua Liu, David L Streiner, Jacques Tremblay, Roger K Pitman
OBJECTIVE: The authors assessed the efficacy of trauma memory reactivation performed under the influence of propranolol, a noradrenergic beta-receptor blocker, as a putative reconsolidation blocker, in reducing symptoms of posttraumatic stress disorder (PTSD). METHOD: This was a 6-week, double-blind, placebo-controlled, randomized clinical trial in 60 adults diagnosed with long-standing PTSD. Propranolol or placebo was administered 90 minutes before a brief memory reactivation session, once a week for 6 consecutive weeks...
January 12, 2018: American Journal of Psychiatry
https://www.readbyqxmd.com/read/29318708/cocaine-conditioned-place-preference-unexpected-suppression-of-preference-due-to-testing-combined-with-strong-conditioning
#2
Lucile Marion-Poll, Antoine Besnard, Sophie Longueville, Emmanuel Valjent, Olivia Engmann, Jocelyne Caboche, Denis Hervé, Jean-Antoine Girault
Conditioned place preference (CPP) is widely used for evaluating the rewarding effects of drugs. Like other memories, CPP is proposed to undergo reconsolidation during which it is unstable and sensitive to pharmacological inhibition. Previous studies have shown that cocaine CPP can be apparently erased by extracellular signal-regulated kinase (ERK) pathway inhibition during cocaine reconditioning (re-exposure to the drug-paired environment in the presence of the drug). Here, we show that blockade of D1 receptors during reconditioning prevented ERK activation and induced a loss of CPP...
January 10, 2018: Addiction Biology
https://www.readbyqxmd.com/read/29287782/naringenin-induced-enhanced-antioxidant-defence-system-meliorates-cholinergic-neurotransmission-and-consolidates-memory-in-male-rats
#3
Laraib Liaquat, Zehra Batool, Sadia Sadir, Sahar Rafiq, SidrahShahzad, Tahira Perveen, Saida Haider
AIMS: Free radical mediated neurotoxicity is a leading cause of neurodegenerative disorders. Neurodegeneration due to oxidative stress can produce cognitive dysfunctions. Flavonoids and curcuminoids are naturally occurring polyphenolic compounds that display a variety of therapeutic importance against oxidative stress. MAIN METHODS: This study was designed to assess potential role of polyphenolic compounds in neurocognitive functions and prevention against oxidative stress...
December 26, 2017: Life Sciences
https://www.readbyqxmd.com/read/29259554/strengthening-of-existing-episodic-memories-through-non-invasive-stimulation-of-prefrontal-cortex-in-older-adults-with-subjective-memory-complaints
#4
Rosa Manenti, Marco Sandrini, Elena Gobbi, Chiara Cobelli, Michela Brambilla, Giuliano Binetti, Maria Cotelli
Episodic memory is critical to daily life functioning. This type of declarative memory declines with age and is the earliest cognitive function to be compromised in Alzheimer's disease (AD). Subjective memory complaints are commonly reported by older adults and have been considered a risk factor for developing AD. The possibilities for prevention of memory disorders in older adults have increased substantially in recent years. Previous studies have shown that anodal transcranial Direct Current Stimulation (tDCS) applied over the left lateral prefrontal cortex (PFC) after a contextual reminder strengthened existing verbal episodic memories, conceivably through reconsolidation, in elderly people...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/29258546/hippocampal-calpain-is-required-for-the-consolidation-and-reconsolidation-but-not-extinction-of-contextual-fear-memory
#5
Taikai Nagayoshi, Kiichiro Isoda, Nori Mamiya, Satoshi Kida
Memory consolidation, reconsolidation, and extinction have been shown to share similar molecular signatures, including new gene expression. Calpain is a Ca2+-dependent protease that exerts its effects through the proteolytic cleavage of target proteins. Neuron-specific conditional deletions of calpain 1 and 2 impair long-term potentiation in the hippocampus and spatial learning. Moreover, recent studies have suggested distinct roles of calpain 1 and 2 in synaptic plasticity. However, the role of hippocampal calpain in memory processes, especially memory consolidation, reconsolidation, and extinction, is still unclear...
December 19, 2017: Molecular Brain
https://www.readbyqxmd.com/read/29249946/moderate-partially-reduplicated-conditioned-stimuli-as-retrieval-cue-can-increase-effect-on-preventing-relapse-of-fear-to-compound-stimuli
#6
Junjiao Li, Wei Chen, Jingwen Caoyang, Wenli Wu, Jing Jie, Liang Xu, Xifu Zheng
The theory of memory reconsolidation argues that consolidated memory is not unchangeable. Once a memory is reactivated it may go back into an unstable state and need new protein synthesis to be consolidated again, which is called "memory reconsolidation". Boundary studies have shown that interfering with reconsolidation through pharmacologic or behavioral intervention can lead to the updating of the initial memory, for example, erasing undesired memories. Behavioral procedures based on memory reconsolidation interference have been shown to be an effective way to inhibit fear memory relapse after extinction...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/29248756/changes-in-the-element-concentration-of-the-dorsal-hippocampus-ca1-region-during-memory-consolidation-and-reconsolidation
#7
Paulo Fernandes Costa Jobim, Carla Eliete Iochims Dos Santos, Luka Jeromel, Primoz Pellicon, Livio Amaral, Johnny Ferraz Dias
The concentration and distribution of Mg, P, Cl, K, Cu and Zn in the dorsal hippocampus CA1 region of rat brains were studied during memory consolidation and reconsolidation processes stimulated with inhibitory avoidance (IA) tests. Experimental rats were divided into four groups: i) group not submitted to inhibitory avoidance task (IA-N); ii) group submitted to inhibitory avoidance training session (IA-Y); iii) group submitted to inhibitory avoidance reactivation session but did not step down from the platform (IAR-N); and iv) group submitted to avoidance reactivation session and stepped down from the platform (IAR-Y)...
December 14, 2017: Journal of Chemical Neuroanatomy
https://www.readbyqxmd.com/read/29241423/reconsolidation-of-traumatic-memories-for-ptsd-a-randomized-controlled-trial-of-74-male-veterans
#8
Richard Gray, Denise Budden-Potts, Frank Bourke
DESIGN: A randomized waitlist-controlled design (n = 74) examined the efficacy of Reconsolidation of Traumatic Memories (RTM) among male veterans with current-month flashbacks and nightmares. Volunteers were randomly assigned to immediate treatment (three 120-minute sessions of RTM), or to a 3-week waiting condition before receiving the RTM treatment. Blinded psychometricians evaluated the symptoms at intake, 2 weeks, and 6 weeks post. Wait-listed participants were re-evaluated and then treated...
December 14, 2017: Psychotherapy Research: Journal of the Society for Psychotherapy Research
https://www.readbyqxmd.com/read/29225045/post-reexposure-administration-of-riluzole-attenuates-the-reconsolidation-of-conditioned-fear-memory-in-rats
#9
Kie Akagi, Misa Yamada, Akiyoshi Saitoh, Jun-Ichiro Oka, Mitsuhiko Yamada
Recently, we demonstrated that riluzole, which has been shown to block the glutamatergic system, facilitates fear extinction in rats. Here, we undertook experiments on contextual fear conditioning to clarify the actions of riluzole on the reconsolidation of fear memory in rats. We used the fast-acting benzodiazepine midazolam as a reconsolidation-inhibiting control drug. We demonstrated that riluzole (3 mg/kg) and midazolam (1 mg/kg) impaired the reconsolidation of contextual fear memory. Results from spontaneous recovery experiments also suggested that riluzole attenuated reconsolidation...
December 7, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/29216351/1-adrenoceptor-in-the-central-amygdala-is-required-for-unconditioned-stimulus-induced-drug-memory-reconsolidation
#10
Huiwen Zhu, Yiming Zhou, Zhiyuan Liu, Xi Chen, Yanqing Li, Xing Liu, Lan Ma
Background: Drug memories become labile and reconsolidated after retrieval by presentation of environmental cues (conditioned stimulus, CS) or drugs (unconditioned stimulus, US). Whether CS- and US-retrieval trigger different memory reconsolidation processes is not clear. Methods: Protein synthesis inhibitor or β-AR antagonist was systemically administrated or intra-central amygdala (CeA) infused immediately after cocaine re-exposure in cocaine-conditioned place preference (CPP) or self-administration (SA) mice models...
December 5, 2017: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29191578/gastrin-releasing-peptide-attenuates-fear-memory-reconsolidation
#11
A Murkar, P Kent, C Cayer, J James, Z Merali
BACKGROUND: Gastrin Releasing Peptide (GRP) may play a role in fear learning. The GRP Receptor is expressed in the basolateral amygdala and hippocampus, and central administration of GRP mediates fear learning. The effects of GRP on reconsolidation, however, have been minimally explored. Reconsolidation, the process by which formed memories are rendered labile following recall, provides a window of opportunity for pharmacological intervention. Although evidence suggests the window of opportunity to alter reactivated consolidation memory can be as long as 6h, shorter intervals have not been extensively investigated...
November 27, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/29181814/a-high-working-memory-load-prior-to-memory-retrieval-reduces-craving-in-non-treatment-seeking-problem-drinkers
#12
Anne Marije Kaag, Anna E Goudriaan, Taco J De Vries, Tommy Pattij, Reinout W Wiers
BACKGROUND: Reconsolidation-based interventions have been suggested to be a promising treatment strategy for substance use disorders. In this study, we aimed to investigate the effectiveness of a working memory intervention to interfere with the reconsolidation of alcohol-related memories in a sample of non-treatment seeking heavy drinkers. METHODS: Participants were randomized to one of the two conditions that underwent a 3-day intervention: in the experimental condition, a 30-min working memory training was performed immediately after a 15-min memory retrieval session (i...
November 27, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/29178010/psychedelics-and-reconsolidation-of-traumatic-and-appetitive-maladaptive-memories-focus-on-cannabinoids-and-ketamine
#13
REVIEW
Liana Fattore, Alessandro Piva, Mary Tresa Zanda, Guido Fumagalli, Cristiano Chiamulera
RATIONALE: Clinical data with 3,4-methylenedioxymethamphetamine (MDMA) in post-traumatic stress disorder (PTSD) patients recently stimulated interest on the potential therapeutic use of psychedelics in disorders characterized by maladaptive memories, including substance use disorders (SUD). The rationale for the use of MDMA in PTSD and SUD is being extended to a broader beneficial "psychedelic effect," which is supporting further clinical investigations, in spite of the lack of mechanistic hypothesis...
November 25, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/29163309/eye-movement-desensitization-and-reprocessing-and-slow-wave-sleep-a-putative-mechanism-of-action
#14
Marco Pagani, Benedikt L Amann, Ramon Landin-Romero, Sara Carletto
Eye Movement Desensitization and Reprocessing (EMDR) is considered highly efficacious for the treatment of Post-traumatic Stress Disorder and has proved to be a valid treatment approach with a wide range of applications. However, EMDR's mechanisms of action is not yet fully understood. This is an active area of clinical and neurophysiological research, and several different hypotheses have been proposed. This paper discusses a conjecture which focuses on the similarity between the delta waves recorded by electroencephalography during Slow Wave Sleep (SWS) and those registered upon typical EMDR bilateral stimulation (eye movements or alternate tapping) during recurrent distressing memories of an emotionally traumatic event...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/29152159/tetris-and-word-games-lead-to-fewer-intrusive-memories-when-applied-several-days-after-analogue-trauma
#15
Muriel A Hagenaars, Emily A Holmes, Fayette Klaassen, Bernet Elzinga
Background: Intrusive trauma memories are a key symptom of posttraumatic stress disorder (PTSD), so disrupting their recurrence is highly important. Intrusion development was hindered by visuospatial interventions administered up to 24 hours after analogue trauma. It is unknown whether interventions can be applied later, and whether modality or working-memory load are crucial factors. Objectives: This study tested: (1) whether a visuospatial task would lead to fewer intrusions compared to a reactivation-only group when applied after memory reactivation four days after analogue trauma exposure (extended replication), (2) whether both tasks (i...
2017: European Journal of Psychotraumatology
https://www.readbyqxmd.com/read/29124534/anterograde-amnesia-induced-by-disruption-of-consolidation-or-reconsolidation-of-long-term-memory
#16
V P Nikitin, S V Solntseva, S A Kozyrev
Mechanisms of amnesia caused by impairment of consolidation or reconsolidation of conditioned food aversion memory with protein synthesis inhibitor cycloheximide were studied in Helix lucorum. Cycloheximide injection during training or memory reconsolidation in trained snails produced amnesia. In both cases, repeated training 10 days after amnesia induction led to short-term memory formation, while long-term memory was not formed, despite the fact that the number of conditioned and reinforcing stimuli combinations was higher than during initial training...
November 9, 2017: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/29110816/forgetting-to-be-addicted-reconsolidation-and-the-disconnection-of-things-past
#17
Alec Solway, Xiaosi Gu, P Read Montague
No abstract text is available yet for this article.
December 1, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/29106571/retrieval-induced-upregulation-of-tet3-in-pyramidal-neurons-of-the-dorsal-hippocampus-mediates-cocaine-associated-memory-reconsolidation
#18
Cao Liu, Xue Sun, Zhilin Wang, Qiumin Le, Peipei Liu, Changyou Jiang, Feifei Wang, Lan Ma
Background: Memory retrieval refers to re-exposure to information previously encoded and stored in the brain. Following retrieval, a once-consolidated memory destabilizes and undergoes reconsolidation, during which gene expression changes to restabilize memory. Investigating epigenetic regulation during reconsolidation could provide insights into normal memory formation and pathological memory associated with psychiatric disorders. Methods: We used cocaine-induced conditioned place preference (CPP) to assess the cocaine-associated memory of mice and used chemogenetic methods to manipulate the activity of the pyramidal neurons in the dHC...
November 2, 2017: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29054430/nmda-receptor-dependent-changes-in-c-fos-and-p-creb-signaling-following-extinction-and-reinstatement-of-morphine-place-preference
#19
Ali Siahposht-Khachaki, Somayeh Ezzatpanah, Yasaman Razavi, Abbas Haghparast
Neural circuitry comprising the ventral tegmental area, nucleus accumbens (NAc), prefrontal cortex (PFC) and hippocampus (HIP) has a main role in reward phenomena. Previous behavioral studies indicated that intracerebroventricular administration of AP5 (NMDA glutamate receptor antagonist) and CNQX (AMPA/kainate glutamate receptor antagonist) during the extinction and before reinstatement of morphine-induced conditioned place preference (CPP) reduced the extinction period and reinstatement of morphine-CPP. Therefore, in the present study, we tried to evaluate the effect of antagonism of NMDA glutamate receptors on the p-CREB/CREB ratio and c-fos expression in the NAc, PFC and HIP during these two phases of morphine-CPP in male adult albino Wistar rats...
October 17, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/29042315/il-1%C3%AE-reduces-glua1-phosphorylation-and-its-surface-expression-during-memory-reconsolidation-and-%C3%AE-melanocyte-stimulating-hormone-can-modulate-these-effects
#20
Ivana Machado, Helgi B Schiöth, Mercedes Lasaga, Teresa Scimonelli
Pro-inflammatory cytokines can affect cognitive processes such as learning and memory. Particularly, interleukin-1β (IL-1β) influences hippocampus-dependent memories. We previously reported that administration of IL-1β in dorsal hippocampus impaired contextual fear memory reconsolidation. This effect was reversed by the melanocortin alpha-melanocyte-stimulating hormone (α-MSH). Our results also demonstrated that IL-1β produced a significant decrease in glutamate release from dorsal hippocampus synaptosomes after reactivation of the fear memory...
October 14, 2017: Neuropharmacology
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