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Reconsolidation

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https://www.readbyqxmd.com/read/27919830/newly-acquired-and-reactivated-contextual-fear-memories-are-more-intense-and-prone-to-generalize-after-activation-of-prelimbic-cortex-nmda-receptors
#1
Ana C Vanvossen, Marina A M Portes, Rafael Scoz-Silva, Hugo B Reichmann, Cristina A J Stern, Leandro J Bertoglio
Activity in the rodent prelimbic (PL) cortex contributes to consolidation, retrieval and reconsolidation of learned fear. The PL cortex is considered homologous to the primate dorsal anterior cingulate cortex (dACC). In patients with post-traumatic stress disorder (PTSD), the dACC is often reported to be hyperactive after acquisition and/or around the retrieval of the traumatic memory. It is still unknown, however, whether there is a relationship between altered dACC functioning at these time points and PTSD-associated behavioral outcomes, such as fear overgeneralization...
December 2, 2016: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/27918276/repeated-recall-and-pkm%C3%AE-maintain-fear-memories-in-juvenile-rats
#2
Chicora F Oliver, Patricia Kabitzke, Peter Serrano, Laura J Egan, Gordon A Barr, Harry N Shair, Christoph Wiedenmayer
We examined the neural substrates of fear memory formation and maintenance when repeated recall was used to prevent forgetting in young animals. In contrast to adult rats, juveniles failed to show contextual fear responses at 4 d post-fear conditioning. Reconsolidation sessions 3 and 6 d after conditioning restored contextual fear responses in juveniles 7 d after initial training. In juveniles that received reconsolidation sessions, protein kinase M zeta (PKMζ) increased in the amygdala, but not in the hippocampus...
December 2016: Learning & Memory
https://www.readbyqxmd.com/read/27885549/memory-reconsolidation
#3
Josue Haubrich, Karim Nader
Scientific advances in the last decades uncovered that memory is not a stable, fixed entity. Apparently stable memories may become transiently labile and susceptible to modifications when retrieved due to the process of reconsolidation. Here, we review the initial evidence and the logic on which reconsolidation theory is based, the wide range of conditions in which it has been reported and recent findings further revealing the fascinating nature of this process. Special focus is given to conceptual issues of when and why reconsolidation happen and its possible outcomes...
November 25, 2016: Current Topics in Behavioral Neurosciences
https://www.readbyqxmd.com/read/27871996/the-role-of-glucocorticoids-in-emotional-memory-reconsolidation-review
#4
REVIEW
Shira Meir Drexler, Oliver T Wolf
Glucocorticoids are secreted following exposure to stressful events. Their modulating role on memory reconsolidation, a post-retrieval process of re-stabilization, has been investigated only recently, at times with conflicting results. The goal of this review is twofold. First, to establish the modulating role of glucocorticoids on memory reconsolidation. Second, to point the potential factors and confounds that might explain the seemingly paradoxical findings. Here we review recent pharmacological studies, conducted in rodents and humans, which suggest a critical role of glucocorticoids in this post-retrieval process...
November 18, 2016: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/27869801/direct-dorsal-hippocampal-prelimbic-cortex-connections-strengthen-fear-memories
#5
Xiaojing Ye, Dana Kapeller-Libermann, Alessio Travaglia, M Carmen Inda, Cristina M Alberini
The ability to regulate the consolidation and strengthening of memories for threatening experiences is critical for mental health, and its dysregulation may lead to psychopathologies. Re-exposure to the context in which the threat was experienced can either increase or decrease fear response through distinct processes known, respectively, as reconsolidation or extinction. Using a context retrieval-dependent memory-enhancement model in rats, we report that memory strengthens through activation of direct projections from dorsal hippocampus to prelimbic (PL) cortex and activation of critical PL molecular mechanisms that are not required for extinction...
November 21, 2016: Nature Neuroscience
https://www.readbyqxmd.com/read/27827903/no-effect-of-cathodal-transcranial-direct-current-stimulation-on-fear-memory-in-healthy-human-subjects
#6
Aditya Mungee, Max Burger, Malek Bajbouj
BACKGROUND: Studies have demonstrated that fear memories can be modified using non-invasive methods. Recently, we demonstrated that anodal transcranial direct current stimulation (tDCS) of the right dorsolateral prefrontal cortex is capable of enhancing fear memories. Here, we examined the effects of cathodal tDCS of the right dorsolateral prefrontal cortex during fear reconsolidation in humans. METHODS: Seventeen young, healthy subjects were randomly assigned to two groups, which underwent fear conditioning with mild electric stimuli paired with a visual stimulus...
November 4, 2016: Brain Sciences
https://www.readbyqxmd.com/read/27815213/different-dimensions-of-the-prediction-error-as-a-decisive-factor-for-the-triggering-of-the-reconsolidation-process
#7
M Agustina López, M Jimena Santos, Santiago Cortasa, Rodrigo S Fernández, Martin Carbó Tano, María E Pedreira
The reconsolidation process is the mechanism by which strength and/or content of consolidated memories are updated. Prediction error (PE) is the difference between the prediction made and current events. It is proposed as a necessary condition to trigger the reconsolidation process. Here we analyzed deeply the role of the PE in the associative memory reconsolidation in the crab Neohelice granulata. An incongruence between the learned temporal relationship between conditioned and unconditioned stimuli (CS-US) was enough to trigger the reconsolidation process...
December 2016: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/27733615/memory-retrieval-has-a-dynamic-influence-on-the-maintenance-mechanisms-that-are-sensitive-to-%C3%AE-inhibitory-peptide-zip
#8
David Levitan, Yaihara Fortis-Santiago, Joshua A Figueroa, Emily E Reid, Takashi Yoshida, Nicholas C Barry, Abigail Russo, Donald B Katz
: In neuroscientists' attempts to understand the long-term storage of memory, topics of particular importance and interest are the cellular and system mechanisms of maintenance (e.g., those sensitive to ζ-inhibitory peptide, ZIP) and those induced by memory retrieval (i.e., reconsolidation). Much is known about each of these processes in isolation, but less is known concerning how they interact. It is known that ZIP sensitivity and memory retrieval share at least some molecular targets (e...
October 12, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27728875/different-contribution-of-glucocorticoids-in-the-basolateral-amygdala-to-the-formation-and-expression-of-opiate-withdrawal-associated-memories
#9
Daniel García-Pérez, Szilamer Ferenczi, Krisztina J Kovács, M Luisa Laorden, M Victoria Milanés, Cristina Núñez
Drug-withdrawal aversive memories generate a motivational state leading to compulsive drug taking, with plasticity changes in the basolateral amygdala (BLA) being essential in aversive motivational learning. The conditioned-place aversion (CPA) paradigm allows for measuring the negative affective component of drug withdrawal. First, CPA triggers association between negative affective consequences of withdrawal with context (memory consolidation). Afterwards, when the animals are re-exposed to the paired environment, they avoid it due to the association between the context and aversive memories (memory retrieval)...
September 28, 2016: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/27728795/neuroscience-this-is-not-a-spider
#10
Philipp Homan, Daniela Schiller
Long-term memories of fear have been notoriously difficult to alter. A new study finds access through the window of reconsolidation.
October 10, 2016: Current Biology: CB
https://www.readbyqxmd.com/read/27727241/modulation-of-fear-extinction-processes-using-transcranial-electrical-stimulation
#11
R Abend, I Jalon, G Gurevitch, R Sar-El, T Shechner, D S Pine, T Hendler, Y Bar-Haim
Research associates processes of fear conditioning and extinction with treatment of anxiety and stress-related disorders. Manipulation of these processes may therefore be beneficial for such treatment. The current study examines the effects of electrical brain stimulation on fear extinction processes in healthy humans in order to assess its potential relevance for treatment enhancement. Forty-five participants underwent a 3-day fear conditioning and extinction paradigm. Electrical stimulation targeting the medial prefrontal cortex was applied during the extinction-learning phase (Day 2)...
October 11, 2016: Translational Psychiatry
https://www.readbyqxmd.com/read/27720856/sleep-s-role-in-the-reconsolidation-of-declarative-memories
#12
Jens G Klinzing, Björn Rasch, Jan Born, Susanne Diekelmann
Sleep is known to support the consolidation of newly encoded and initially labile memories. Once consolidated, remote memories can return to a labile state upon reactivation and need to become reconsolidated in order to persist. Here we asked whether sleep also benefits the reconsolidation of remote memories after their reactivation and how reconsolidation during sleep compares to sleep-dependent consolidation processes. In three groups, participants were trained on a visuo-spatial learning task in the presence of a contextual odor...
December 2016: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/27670620/qualitatively-different-memory-states-in-lymnaea-as-shown-by-differential-responses-to-propranolol
#13
Emily Hughes, Tamila Shymansky, Hiroshi Sunada, Ken Lukowiak
Mixed results with the synthetic β-adrenergic receptor blocker, propranolol, have been reported in human populations with regards to its therapeutic efficacy for PTSD treatments targeting the memory reconsolidation process. Stress alters the ability to form and maintain memory, but whether the causal neuronal mechanisms underling memory formation in PTSD are similar to normal memory is not clear. Here, we use Lymnaea to study the effects of combinations of stressors on the quality of the formed memory state...
December 2016: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/27669409/hippocampal-neurogenesis-enhancers-promote-forgetting-of-remote-fear-memory-after-hippocampal-reactivation-by-retrieval
#14
Rie Ishikawa, Hotaka Fukushima, Paul W Frankland, Satoshi Kida
Forgetting of recent fear memory is promoted by treatment with memantine (MEM), which increases hippocampal neurogenesis. The approaches for treatment of post-traumatic stress disorder (PTSD) using rodent models have focused on the extinction and reconsolidation of recent, but not remote, memories. Here we show that, following prolonged re-exposure to the conditioning context, enhancers of hippocampal neurogenesis, including MEM, promote forgetting of remote contextual fear memory. However, these interventions are ineffective following shorter re-exposures...
2016: ELife
https://www.readbyqxmd.com/read/27660077/mechanisms-underlying-long-term-fear-memory-formation-from-a-metaplastic-neuronal-state
#15
Ryan G Parsons, David L Walker, Michael Davis
We previously showed that a single weak fear conditioning trial, that does not produce a long-term fear memory (LTM), appeared to prime memory formation such that when a second trial followed within a circumscribed time window a robust and long-lasting fear memory was formed. We also showed that this priming effect could be blocked if we interfered with protein kinase A (PKA) signaling in the amygdala during the first conditioning trial. The goals of the current study were to determine if LTM formation after the second trial depends on PKA signaling in the amygdala and to characterize the underlying memory processes engaged during the second trial that allows for LTM formation...
December 2016: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/27605622/increasing-the-glun2a-glun2b-ratio-in-neurons-of-the-mouse-basal-and-lateral-amygdala-inhibits-the-modification-of-an-existing-fear-memory-trace
#16
Roopashri Holehonnur, Aarron J Phensy, Lily J Kim, Milica Milivojevic, Dat Vuong, Delvin K Daison, Saira Alex, Michael Tiner, Lauren E Jones, Sven Kroener, Jonathan E Ploski
UNLABELLED: Reconsolidation updating is a form of memory modification in which an existing memory can become destabilized upon retrieval and subsequently be modified via protein-synthesis-dependent reconsolidation. However, not all memories appear to destabilize upon retrieval and thus are not modifiable via reconsolidation updating approaches and the neurobiological basis for this remains poorly understood. Here, we report that auditory fear memories created with 10 tone-shock pairings are resistant to retrieval-dependent memory destabilization and are associated with an increase in the synaptic GluN2A/GluN2B ratio in neurons of the basal and lateral amygdala (BLA) compared with weaker fear memories created via one or three tone-shock pairings...
September 7, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27595592/parp-1-is-required-for-retrieval-of-cocaine-associated-memory-by-binding-to-the-promoter-of-a-novel-gene-encoding-a-putative-transposase-inhibitor
#17
E Lax, A Friedman, R Massart, R Barnea, L Abraham, D Cheishvili, M Zada, H Ahdoot, T Bareli, G Warhaftig, L Visochek, M Suderman, M Cohen-Armon, M Szyf, G Yadid
Reward-related memory is an important factor in cocaine seeking. One necessary signaling mechanism for long-term memory formation is the activation of poly(ADP-ribose) polymerase-1 (PARP-1), via poly(ADP-ribosyl)ation. We demonstrate herein that auto-poly(ADP-ribosyl)ation of activated PARP-1 was significantly pronounced during retrieval of cocaine-associated contextual memory, in the central amygdala (CeA) of rats expressing cocaine-conditioned place preference (CPP). Intra-CeA pharmacological and short hairpin RNA depletion of PARP-1 activity during cocaine-associated memory retrieval abolished CPP...
September 6, 2016: Molecular Psychiatry
https://www.readbyqxmd.com/read/27594599/affective-change-in-psychodynamic-psychotherapy-theoretical-models-and-clinical-approaches-to-changing-emotions
#18
Claudia Subic-Wrana, Leslie S Greenberg, Richard D Lane, Matthias Michal, Jörg Wiltink, Manfred E Beutel
OBJECTIVES: Affective change has been considered the hallmark of therapeutic change in psychoanalysis. Psychoanalytic writers have begun to incorporate theoretically the advanced understanding of emotional processing and transformation of the affective neurosciences. We ask if this theoretical advancement is reflected in treatment techniques addressing the processing of emotion. METHODS: We review psychoanalytic models and treatment recommendations of maladaptive affect processing in the light of a neuroscientifically informed model of achieving psychotherapeutic change by activation and reconsolidation of emotional memory...
September 2016: Zeitschrift Für Psychosomatische Medizin und Psychotherapie
https://www.readbyqxmd.com/read/27590828/understanding-posttraumatic-stress-disorder-through-fear-conditioning-extinction-and-reconsolidation
#19
REVIEW
Mariella Bodemeier Loayza Careaga, Carlos Eduardo Neves Girardi, Deborah Suchecki
Careaga MBL, Girardi CEN, Suchecki D. Understanding posttraumatic stress disorder through fear conditioning, extinction and reconsolidation. NEUROSCI BIOBEHAV REV -Posttraumatic stress disorder (PTSD) is a psychopathology characterized by exacerbation of fear response. A dysregulated fear response may be explained by dysfunctional learning and memory, a hypothesis that was proposed decades ago. A key component of PTSD is fear conditioning and the study of this phenomenon in laboratory has expanded the understanding of the underlying neurobiological changes in PTSD...
December 2016: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/27582698/reconsolidation-of-motor-memories-is-a-time-dependent-process
#20
Toon T de Beukelaar, Daniel G Woolley, Kaat Alaerts, Stephan P Swinnen, Nicole Wenderoth
Reconsolidation is observed when a consolidated stable memory is recalled, which renders it transiently labile and requires re-stabilization. Motor memory reconsolidation has previously been demonstrated using a three-day design: on day 1 the memory is encoded, on day 2 it is reactivated and experimentally manipulated, and on day 3 memory strength is tested. The aim of the current study is to determine specific boundary conditions in order to consistently degrade motor memory through reconsolidation paradigms...
2016: Frontiers in Human Neuroscience
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