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Reconsolidation

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https://www.readbyqxmd.com/read/29752843/propofol-anesthesia-exposure-and-nonaversive-memory-retrieval-and-the-expression-of-molecules-involved-in-memory-process-in-the-dorsal-hippocampus-in-peripubertal-rats
#1
Željko Pavković, Desanka Milanović, Sabera Ruždijić, Selma Kanazir, Vesna Pešić
BACKGROUND: The effects of anesthetic drugs on postoperative cognitive function in children are not well defined and have not been experimentally addressed. AIMS: The present study aimed to examine the influence of propofol anesthesia exposure on nonaversive hippocampus-dependent learning and biochemical changes involved in memory process in the dorsal hippocampus, in peripubertal rats as the rodent model of periadolescence. METHODS: The intersession spatial habituation and the novel object recognition tasks were used to assess spatial and nonspatial, nonaversive hippocampus-dependent learning...
May 12, 2018: Paediatric Anaesthesia
https://www.readbyqxmd.com/read/29747244/nucleus-reuniens-of-the-thalamus-controls-fear-memory-intensity-specificity-and-long-term-maintenance-during-consolidation
#2
Fernanda Troyner, Maira A Bicca, Leandro J Bertoglio
The thalamic nucleus reuniens (NR) has been shown to support bidirectional medial prefrontal cortex-hippocampus communication and synchronization relevant for cognitive processing. Using non-selective or prolonged inactivation of the NR, previous studies reported its activity positively modulates aversive memory consolidation. Here we examined the NR's role in consolidating contextual fear memories with varied strength, at both recent and more remote time points, using muscimol-induced temporary inactivation in rats...
May 10, 2018: Hippocampus
https://www.readbyqxmd.com/read/29744783/behavioral-interventions-to-eliminate-fear-responses
#3
REVIEW
Jingli Yue, Le Shi, Xiao Lin, Muhammad Zahid Khan, Jie Shi, Lin Lu
Fear memory underlies anxiety-related disorders, including posttraumatic stress disorder (PTSD). PTSD is a fear-based disorder, characterized by difficulties in extinguishing the learned fear response and maintaining extinction. Currently, the first-line treatment for PTSD is exposure therapy, which forms an extinction memory to compete with the original fear memory. However, the extinguished fear often returns under numerous circumstances, suggesting that novel methods are needed to eliminate fear memory or facilitate extinction memory...
May 7, 2018: Science China. Life Sciences
https://www.readbyqxmd.com/read/29740084/periodical-reactivation-under-the-effect-of-caffeine-attenuates-fear-memory-expression-in-rats
#4
Lizeth K Pedraza, Rodrigo O Sierra, Fernanda N Lotz, Lucas de Oliveira Alvares
In the last decade, several studies have shown that fear memories can be attenuated by interfering with reconsolidation. However, most of the pharmacological agents used in preclinical studies cannot be administered to humans. Caffeine is one of the world's most popular psychoactive drugs and its effects on cognitive and mood states are well documented. Nevertheless, the influence of caffeine administration on fear memory processing is not as clear. We employed contextual fear conditioning in rats and acute caffeine administration under a standard memory reconsolidation protocol or periodical memory reactivation...
May 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29734740/mood-regulation-focused-cbt-based-on-memory-reconsolidation-reduced-suicidal-ideation-and-depression-in-youth-in-a-randomised-controlled-study
#5
Göran Högberg, Tore Hällström
Suicide attempts and suicidal ideation in adolescence are considered to be related to suicide and psychiatric adversity later in life. Secondary prevention by improving the treatment of suicidal youth is a distinct possibility. In this study, treatment with a systematised mood-regulation focused cognitive behavioural therapy (MR-CBT) (n = 15) was compared with treatment as usual (TAU) (n = 12) in a group of depressed adolescents in a clinical setting. MR-CBT focuses on mood regulation by means of counter conditioning with memory reconsolidation being the proposed mechanism of change...
May 5, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29731446/anticholinergic-drug-atropine-diminishes-newly-formed-fear-memory-in-male-rats
#6
Sahar Rafiq, Saara Ahmad, Fatima Ahmed, Zehra Batool, Saad Bilal Ahmed, Sadia Saleem, Fizza Naqvi, Laraib Liaquat, Asia Afzal, Saida Haider
Post-traumatic stress disorder (PTSD) is a condition which is triggered shortly after experiencing traumatic events. PTSD is complicated by the fact that people with PTSD often develop additional disorders such as phobias, addiction, depression, panic disorder and obsessive-compulsive disorder. Beta-adrenergic and cholinergic system both are involved in memory formation as well as in emotional response associated with memory. It is reported that the administration of beta-adrenergic and cholinergic antagonist results in the impairment in memory formation...
May 2018: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29717980/5-ht2a-receptor-in-mpfc-influences-context-guided-reconsolidation-of-object-memory-in-perirhinal-cortex
#7
Juan Facundo Morici, Magdalena Miranda, Francisco Tomás Gallo, Belén Zanoni, Pedro Bekinschtein, Noelia V Weisstaub
Context-dependent memories may guide adaptive behavior relaying in previous experience while updating stored information through reconsolidation. Retrieval can be triggered by partial and shared cues. When the cue is presented, the most relevant memory should be updated. In a contextual version of the object recognition task, we examined the effect of medial PFC (mPFC) serotonin 2a receptor (5-HT2aR) blockade during retrieval in reconsolidation of competing objects memories. We found that mPFC 5-HT2aR controls retrieval and reconsolidation of object memories in the perirhinal cortex (PRH), but not in the dorsal hippocampus in rats...
May 2, 2018: ELife
https://www.readbyqxmd.com/read/29704430/calcium-calmodulin-dependent-kinase-ii-and-memory-destabilization-a-new-role-in-memorymaintenance
#8
REVIEW
Fabio Antonio Vigil, Karl Peter Giese
In this review, we discuss the poorly explored role of calcium/calmodulin-dependent protein kinase II (CaMKII) in memory maintenance, and its influence on memory destabilization. After a brief review on CaMKII and memory destabilization, we present critical pieces of evidence suggesting that CaMKII activity increases retrieval-induced memory destabilization. We then proceed to propose two potential molecular pathways to explain the association between CaMKII activation and increased memory destabilization. This review will pinpoint gaps in our knowledge and discuss some "controversial" observations, establishing the basis for new experiments on the role of CaMKII in memory reconsolidation...
April 28, 2018: Journal of Neurochemistry
https://www.readbyqxmd.com/read/29680772/%C3%AE-adrenergic-signaling-is-required-for-the-induction-of-a-labile-state-during-memory-reconsolidation
#9
Chae-Seok Lim, Jae-Ick Kim, Chuljung Kwak, Jaehyun Lee, Eun Hae Jang, Jihae Oh, Bong-Kiun Kaang
Memory reconsolidation is the process by which previously consolidated memories reenter a labile state through reactivation of the memory trace and are actively consolidated through de novo protein synthesis. Although extensive studies have shown that β-adrenergic signaling plays a critical role in the restabilization of reactivated memory, its role in the destabilization of long-term memory is not well-studied. In this study, we found that membrane excitability increased in hippocampal CA1 neurons immediately after the retrieval of contextual fear memory...
April 20, 2018: Brain Research Bulletin
https://www.readbyqxmd.com/read/29674970/hypothesis-the-psychedelic-ayahuasca-heals-traumatic-memories-via-a-sigma-1-receptor-mediated-epigenetic-mnemonic-process
#10
Antonio Inserra
Ayahuasca ingestion modulates brain activity, neurotransmission, gene expression and epigenetic regulation. N,N -Dimethyltryptamine (DMT, one of the alkaloids in Ayahuasca) activates sigma 1 receptor (SIGMAR1) and others. SIGMAR1 is a multi-faceted stress-responsive receptor which promotes cell survival, neuroprotection, neuroplasticity, and neuroimmunomodulation. Simultaneously, monoamine oxidase inhibitors (MAOIs) also present in Ayahuasca prevent the degradation of DMT. One peculiarity of SIGMAR1 activation and MAOI activity is the reversal of mnemonic deficits in pre-clinical models...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29672107/combined-administration-of-mk-801-and-cycloheximide-produces-a-delayed-potentiation-of-fear-discrimination-memory-extinction
#11
Daniel E Kochli, Tiffany L Campbell, Ethan W Hollingsworth, Rain S Lab, Abagail F Postle, Megan M Perry, Victoria M Mordzinski, Jennifer J Quinn
Mixed evidence exists regarding the role of N-methyl-D-aspartate (NMDA) receptors in memory reconsolidation. We provide no evidence that NMDA receptors are involved with memory reconsolidation, but instead demonstrate that prereactivation systemic MK-801 injection, combined with postreactivation intrabasolateral amygdala (BLA) cycloheximide infusion, produces a delayed potentiation of extinction learning. These data suggest that an interaction between NMDA antagonism and protein synthesis inhibition may enhance extinction by exerting effects outside of the intended reconsolidation manipulation window...
April 2018: Behavioral Neuroscience
https://www.readbyqxmd.com/read/29667304/inhibition-of-alpha7-nicotinic-receptors-in-the-ventral-hippocampus-selectively-attenuates-reinstatement-of-morphine-conditioned-place-preference-and-associated-changes-in-ampa-receptor-binding
#12
Victoria L Wright, Polymnia Georgiou, Alexis Bailey, David J Heal, Christopher P Bailey, Susan Wonnacott
Recurrent relapse is a major problem in treating opiate addiction. Pavlovian conditioning plays a role in recurrent relapse whereby exposure to cues learned during drug intake can precipitate relapse to drug taking. α7 nicotinic acetylcholine receptors (nAChRs) have been implicated in attentional aspects of cognition and mechanisms of learning and memory. In this study we have investigated the role of α7 nAChRs in morphine-conditioned place preference (morphine-CPP). CPP provides a model of associative learning that is pertinent to associative aspects of drug dependence...
April 17, 2018: Addiction Biology
https://www.readbyqxmd.com/read/29649583/noradrenergic-%C3%AE-receptor-antagonism-in-the-basolateral-amygdala-impairs-reconsolidation-but-not-extinction-of-alcohol-self-administration-intra-bla-propranolol-impairs-reconsolidation-of-alcohol-self-administration
#13
Rose Chesworth, Laura H Corbit
A critical barrier to recovery from alcohol addiction is relapse propensity. Alcohol cues can trigger relapse, and pharmacologically facilitating processes such as extinction, which decreases cue associations, may help prevent relapse. The noradrenergic system mediates extinction learning for alcohol; however, the neural locus of this effect is unknown. This study sought to determine whether the basolateral amygdala (BLA), a region critical for fear extinction, also mediates extinction of alcohol seeking. Hooded Wistar rats (N = 12-15 per experiment) were implanted with bilateral cannula targeting the BLA and trained to lever press for 10% ethanol during auditory or visual cues...
April 9, 2018: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/29615619/pharmacologically-induced-amnesia-for-learned-fear-is-time-and-sleep-dependent
#14
Merel Kindt, Marieke Soeter
The discovery in animal research that fear memories may change upon retrieval has sparked a wave of interest into whether this phenomenon of reconsolidation also occurs in humans. The critical conditions under which memory reconsolidation can be observed and targeted in humans, however, remain elusive. Here we report that blocking beta-adrenergic receptors in the brain, either before or after reactivation, effectively neutralizes the expression of fear memory. We show a specific time-window during which beta-adrenergic receptors are involved in the reconsolidation of fear memory...
April 3, 2018: Nature Communications
https://www.readbyqxmd.com/read/29609080/behavioral-tagging-and-capture-long-term-memory-decline-in-middle-aged-rats
#15
Alexandra Gros, Szu-Han Wang
Decline in cognitive functions, including hippocampus-dependent spatial memory, is commonly observed at a later stage of aging (e.g., >20 months old in rodents) and typically studied after a discrete learning event. How normal aging, particularly at an early stage, affects the modulatory aspect of memory persistence is underinvestigated. Previous studies in young animals show that weak, fading memories can last longer if a modulating event, such as spatial novelty, is introduced around memory encoding. This is known as behavioral tagging and capture (BTC)...
March 10, 2018: Neurobiology of Aging
https://www.readbyqxmd.com/read/29578033/propranolol-produces-short-term-facilitation-of-extinction-in-a-rabbit-model-of-post-traumatic-stress-disorder
#16
Lauren B Burhans, Carrie A Smith-Bell, Bernard G Schreurs
Post-traumatic stress disorder (PTSD) is a learning-based anxiety disorder with significant public health challenges due to difficulties in treating the complex, multiple symptomology. We have developed an animal model of PTSD, based on Pavlovian eyeblink conditioning in rabbits, that addresses two key features: conditioned responses (CRs) to cues associated with an aversive event and a form of conditioned hyperarousal referred to as conditioning-specific reflex modification (CRM). We have found previously that unpaired extinction is ideal for reducing both CRs and CRM simultaneously and shows sensitivity to systemic serotonergic and glutamatergic manipulations...
March 22, 2018: Neuropharmacology
https://www.readbyqxmd.com/read/29563072/d-serine-is-a-potential-biomarker-for-clinical-response-in-treatment-of-post-traumatic-stress-disorder-using-r-s-ketamine-infusion-and-timber-psychotherapy-a-pilot-study
#17
Basant Pradhan, Ludmil Mitrev, Ruin Moaddell, Irving W Wainer
Post-traumatic stress disorder (PTSD) is a chronic and debilitating condition that is often refractory to standard frontline antidepressant therapy. A promising new approach to PTSD therapy is administration of a single sub-anesthetic dose of (R,S)-ketamine (Ket). The treatment produces rapid and significant therapeutic response, which lasts for only 4-7 days. In one of our studies, the mean duration of response was increased to 33 days when Ket administration was combined with a mindfulness-based cognitive therapy, Trauma Interventions using Mindfulness Based Extinction and Reconsolidation (TIMBER)...
March 18, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29555855/autophagy-enhances-memory-erasure-through-synaptic-destabilization
#18
Mohammad Shehata, Kareem Abdou, Kiriko Choko, Mina Matsuo, Hirofumi Nishizono, Kaoru Inokuchi
There is substantial interest in memory reconsolidation as a target for the treatment of anxiety disorders such as post-traumatic stress disorder (PTSD). However, its applicability is restricted by reconsolidation-resistant boundary conditions that constrain the initial memory destabilization. In this study, we investigated whether the induction of synaptic protein degradation through autophagy modulation, a major protein degradation pathway, can enhance memory destabilization upon retrieval and whether it can be utilized to overcome these conditions...
March 19, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29553773/behavioral-disruption-of-memory-reconsolidation-from-bench-to-bedside-and-back-again
#19
Shira Meir Drexler, Oliver T Wolf
During the postretrieval reconsolidation "window", memories can be disrupted, strengthened, or updated using various pharmacological and behavioral manipulations. Behavioral manipulations are more ecologically valid, thus allowing better understating of memory modification under natural conditions, but they can also be less potent compared to pharmacological interventions. In this review we present the current human and animal literature, aiming to understand the modulatory factors (i.e., task relevance, complexity, intensity) that promote reconsolidation disruption in purely behavioral means...
February 2018: Behavioral Neuroscience
https://www.readbyqxmd.com/read/29531288/global-delay-in-nascent-strand-dna-methylation
#20
Jocelyn Charlton, Timothy L Downing, Zachary D Smith, Hongcang Gu, Kendell Clement, Ramona Pop, Veronika Akopian, Sven Klages, David P Santos, Alexander M Tsankov, Bernd Timmermann, Michael J Ziller, Evangelos Kiskinis, Andreas Gnirke, Alexander Meissner
Cytosine methylation is widespread among organisms and essential for mammalian development. In line with early postulations of an epigenetic role in gene regulation, symmetric CpG methylation can be mitotically propagated over many generations with extraordinarily high fidelity. Here, we combine BrdU labeling and immunoprecipitation with genome-wide bisulfite sequencing to explore the inheritance of cytosine methylation onto newly replicated DNA in human cells. Globally, we observe a pronounced lag between the copying of genetic and epigenetic information in embryonic stem cells that is reconsolidated within hours to accomplish faithful mitotic transmission...
April 2018: Nature Structural & Molecular Biology
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