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https://www.readbyqxmd.com/read/28422273/a-survey-of-women-s-awareness-of-and-reasons-for-lack-of-postfracture-osteoporotic-care
#1
Denise M Boudreau, Onchee Yu, Akhila Balasubramanian, Heidi Wirtz, Andreas Grauer, Daria B Crittenden, Delia Scholes
OBJECTIVES: To identify women's beliefs and other factors associated with lack of osteoporosis (OP) pharmacotherapy (OP-RX) during the 6 months after a fragility fracture, including the woman's perspective on fracture risk, OP, and treatment. DESIGN: Cross-sectional. SETTING: Group Health Cooperative, a mixed-model delivery system. PARTICIPANTS: Female Group Health Cooperative enrollees aged 55 and older with an OP-related fracture according to diagnostic and procedure codes from January 1, 2013, to March 30, 2014 (N = 985)...
April 19, 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/28407408/fmr1-genotype-interacts-with-parenting-stress-to-shape-health-and-functional-abilities-in-older-age
#2
Marsha Mailick, Jinkuk Hong, Jan Greenberg, Leann Smith Dawalt, Mei Wang Baker, Paul J Rathouz
This study investigated the association of genotype (CGG repeats in FMR1) and the health and well-being of 5,628 aging adults (mean age = 71) in a population-based study. Two groups were contrasted: aging parents who had adult children with developmental or mental health disabilities (n = 785; the high-stress parenting group) and aging parents of healthy children who did not have disabilities (n = 4843; the low-stress parenting group). There were significant curvilinear interaction effects between parenting stress group and CGG repeats for body mass index and indicators of health and functional limitations, and the results were suggestive of interactions for limitations in cognitive functioning...
April 13, 2017: American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics
https://www.readbyqxmd.com/read/28406943/defective-enamel-and-bone-development-in-sodium-dependent-citrate-transporter-nact-slc13a5-deficient-mice
#3
Armando R Irizarry, Guirui Yan, Qingqiang Zeng, Jonathan Lucchesi, Matthew J Hamang, Yanfei L Ma, James Xiaojun Rong
There has been growing recognition of the essential roles of citrate in biomechanical properties of mineralized tissues, including teeth and bone. However, the sources of citrate in these tissues have not been well defined, and the contribution of citrate to the regulation of odontogenesis and osteogenesis has not been examined. Here, tooth and bone phenotypes were examined in sodium-dependent citrate transporter (NaCT) Slc13a5 deficient C57BL/6 mice at 13 and 32 weeks of age. Slc13a5 deficiency led to defective tooth development, characterized by absence of mature enamel, formation of aberrant enamel matrix, and dysplasia and hyperplasia of the enamel organ epithelium that progressed with age...
2017: PloS One
https://www.readbyqxmd.com/read/28394961/-frailty-criteria-among-older-people-living-in-the-community-an-update
#4
Evelyn Iriarte, Alejandra-Ximena Araya
Frailty is an important concept in aging research and care. Awareness of frailty signs allows healthcare workers to identify older adults at risk and design interventions to prevent their functional decline, therefore preventing adverse health outcomes. This literature review allows to identify predictors of frailty considering its physical, psychological and social domains. From the evidence found, it is possible to formulate a profile of fragile older people. Finally, future research should focus on the description of psychological and social fragility profiles, on the detection of persons likely to be fragile and finally to define precise instruments to detect fragile people, which should become the gold standards in future research...
November 2016: Revista Médica de Chile
https://www.readbyqxmd.com/read/28391068/abnormal-trajectories-in-cerebellum-and-brainstem-volumes-in-carriers-of-the-fragile-x-premutation
#5
Jun Yi Wang, David Hessl, Randi J Hagerman, Tony J Simon, Flora Tassone, Emilio Ferrer, Susan M Rivera
Fragile X-associated tremor/ataxia syndrome (FXTAS) is a late-onset neurodegenerative disorder typically affecting male premutation carriers with 55-200 CGG trinucleotide repeat expansions in the FMR1 gene after age 50. The aim of this study was to examine whether cerebellar and brainstem changes emerge during development or aging in late life. We retrospectively analyzed magnetic resonance imaging scans from 322 males (age 8-81 years). Volume changes in the cerebellum and brainstem were contrasted with those in the ventricles and whole brain...
March 18, 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/28373068/stereotactic-body-radiotherapy-for-early-stage-non-small-cell-lung-cancer-in-patients-80-years-and-older-a-multi-center-analysis
#6
Richard J Cassidy, Pretesh R Patel, Xinyan Zhang, Robert H Press, Jeffrey M Switchenko, Rathi N Pillai, Taofeek K Owonikoko, Suresh S Ramalingam, Felix G Fernandez, Seth D Force, Walter J Curran, Kristin A Higgins
BACKGROUND: Stereotactic body radiotherapy (SBRT) is the standard of care for medically inoperable early-stage non-small-cell lung cancer. Despite the limited number of octogenarians and nonagenarians on trials of SBRT, its use is increasingly being offered in these patients, given the aging cancer population, medical fragility, or patient preference. Our purpose was to investigate the efficacy, safety, and survival of patients ≥ 80 years old treated with definitive lung SBRT. METHODS: Patients who underwent SBRT were reviewed from 2009 to 2015 at 4 academic centers...
March 16, 2017: Clinical Lung Cancer
https://www.readbyqxmd.com/read/28369069/the-empowerment-of-elderly-patients-with-chronic-obstructive-pulmonary-disease-managing-life-with-the-disease
#7
Zahra Fotokian, Farahnaz Mohammadi Shahboulaghi, Masoud Fallahi-Khoshknab, Ali Pourhabib
Chronic obstructive pulmonary disease (COPD) is a serious health problem that has significant effects on the life status of elderly persons. Use of the empowerment approach is necessary for health promotion in older people with COPD, but little attention has so far been paid to all the dimensions of empowerment in the management of COPD, which would provide useful knowledge regarding elders with COPD. This article reports on a study exploring people's experiences of the empowerment of older people with COPD...
2017: PloS One
https://www.readbyqxmd.com/read/28364146/bundled-payments-in-total-joint-arthroplasty-and-spine-surgery
#8
REVIEW
Rashad Sullivan, Landry D Jarvis, Tadhg O'Gara, Maxwell Langfitt, Cynthia Emory
PURPOSE OF REVIEW: The goal of this manuscript is to provide an overview and analysis of bundled payment models for joint replacement and select spine procedures. Advantages and disadvantages of bundled payment models will be discussed. RECENT FINDINGS: In select populations, bundled payment models have been shown to reduce costs while maintaining satisfactory outcomes. These models have not been tested with complex patient cohorts, such as older adults with fragility hip fractures, and limited data exist with bundled payment analysis in spine procedures...
March 31, 2017: Current Reviews in Musculoskeletal Medicine
https://www.readbyqxmd.com/read/28340130/falling-down-on-the-job-evaluation-and-treatment-of-fall-risk-among-older-adults-with-upper-extremity-fragility-fractures
#9
Christine M McDonough, Carrie H Colla, Donald Carmichael, Anna N A Tosteson, Tor D Tosteson, John-Erik Bell, Robert V Cantu, Jonathan D Lurie, Julie P W Bynum
Background: Clinical practice guidelines recommend fall risk assessment and intervention for older adults who sustain a fall-related injury to prevent future injury and mobility decline. Objective: The aim of this study was to describe how often Medicare beneficiaries with upper extremity fracture receive evaluation and treatment for fall risk. Design: Observational cohort. Methods: Participants were fee-for-service beneficiaries age 66 to 99 treated as outpatients for proximal humerus or distal radius/ulna ("wrist") fragility fractures...
March 1, 2017: Physical Therapy
https://www.readbyqxmd.com/read/28302060/heart-failure-labelled-patients-with-missing-ejection-fraction-in-primary-care-prognosis-and-determinants
#10
Miguel-Angel Muñoz, Xavier Mundet-Tuduri, Jordi Real, José-Luis Del Val, Mar Domingo, Ernest Vinyoles, Ester Calero, Caterina Checa, Nuria Soldevila-Bacardit, José-María Verdú-Rotellar
BACKGROUND: It is common to find a high variability in the accuracy of heart failure (HF) diagnosis in electronic primary care medical records (EMR). Our aims were to ascertain (i) whether the prognosis of HF labelled patients whose ejection fraction (EF) was missing in their EMR differed from those that had it registered, and (ii) the causes contributing to the differences in the availability of EF in EMR. METHODS: Retrospective cohort analyses based on clinical records of HF and attended at 52 primary healthcare centres of Barcelona (Spain)...
March 17, 2017: BMC Family Practice
https://www.readbyqxmd.com/read/28293453/an-overview-and-management-of-osteoporosis
#11
REVIEW
Tümay Sözen, Lale Özışık, Nursel Çalık Başaran
Osteoporosis -related to various factors including menopause and aging- is the most common chronic metabolic bone disease, which is characterized by increased bone fragility. Although it is seen in all age groups, gender, and races, it is more common in Caucasians (white race), older people, and women. With an aging population and longer life span, osteoporosis is increasingly becoming a global epidemic. Currently, it has been estimated that more than 200 million people are suffering from osteoporosis. According to recent statistics from the International Osteoporosis Foundation, worldwide, 1 in 3 women over the age of 50 years and 1 in 5 men will experience osteoporotic fractures in their lifetime...
March 2017: European Journal of Rheumatology
https://www.readbyqxmd.com/read/28286986/age-related-prevalence-of-osteoporosis-and-fragility-fractures-real-world-data-from-an-austrian-menopause-and-osteoporosis-clinic
#12
E P Boschitsch, E Durchschlag, H P Dimai
OBJECTIVES: Age and bone mineral density (BMD) are the most relevant determinants for public health authorities to govern the management of osteoporosis. The objectives of this study were to determine the age-related prevalence of osteopenia and osteoporosis according to WHO criteria and fragility fractures in middle-aged and older women. METHODS: Women ≥40 years, who were referred to a menopause and osteoporosis outpatient clinic for BMD measurements, were assessed for patient characteristics, BMD and previous fragility fractures of the hip, the distal forearm and the vertebrae...
April 2017: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/28285742/peripheral-quantitative-computed-tomography-pqct-measures-contribute-to-the-understanding-of-bone-fragility-in-older-patients-with-low-trauma-fracture
#13
Hongyuan Jiang, Christopher J Yates, Alexandra Gorelik, Ashwini Kale, Qichun Song, John D Wark
Dual-energy X-ray absorptiometry (DXA) as currently used has limitations in identifying patients with osteoporosis and predicting occurrence of fracture. We aimed to express peripheral quantitative computed tomography (pQCT) variables of patients with low-trauma fracture as T-scores by using T-score scales obtained from healthy young women, and to evaluate the potential clinical utility of pQCT for the assessment of bone fragility. Fracture patients were recruited from a fracture liaison service at the Royal Melbourne Hospital...
March 9, 2017: Journal of Clinical Densitometry
https://www.readbyqxmd.com/read/28275838/economic-evaluation-of-a-population-based-osteoporosis-intervention-for-outpatients-with-non-traumatic-non-hip-fractures-the-catch-a-break-1i-type-c-fls
#14
S R Majumdar, D A Lier, D A Hanley, A G Juby, L A Beaupre
Fracture liaison services (FLS) are advocated to improve osteoporosis treatment after fragility fracture, but there are few economic analyses of different models. A population-based 1i [=type C] FLS for non-hip fractures was implemented and it costs $44 per patient and it was very cost-effective ($9200 per QALY gained). Small operational changes would convert it from cost-effective to cost-saving. INTRODUCTION: After fragility fracture, <20% of patients receive osteoporosis treatment...
March 9, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28270664/proton-pump-inhibitors-and-fragility-fractures-in-vulnerable-older-patients
#15
Jan Zirk-Sadowski, Jane A Masoli, W David Strain, Joao Delgado, William Henley, Willy Hamilton, David Melzer, Alessandro Ble
No abstract text is available yet for this article.
March 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/28256011/population-wide-impact-of-non-hip-non-vertebral-fractures-on-mortality
#16
Thach Tran, Dana Bliuc, Tineke van Geel, Jonathan D Adachi, Claudie Berger, Joop van den Bergh, John A Eisman, Piet Geusens, David Goltzman, David A Hanley, Robert G Josse, Stephanie M Kaiser, Christopher S Kovacs, Lisa Langsetmo, Jerilynn C Prior, Tuan V Nguyen, Jacqueline R Center
Data on long-term consequences of non-hip non-vertebral (NHNV) fractures, accounting for approximately two thirds of all fragility fractures are scanty. Our study aimed to quantify the population-wide impact of NHNV fractures on mortality. The national population-based prospective cohort study (Canadian Multicentre Osteoporosis Study) included 5526 community dwelling women and 2163 men aged 50 years or older followed up from July 1995 to September 2013. Population impact number was used to quantify the average number of people for whom one death would be attributable to fracture and case impact number to quantify the number of deaths out of which one would be attributable to a fracture...
March 3, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/28247259/vertebral-fracture-assessment-in-patients-presenting-with-a-non-hip-non-vertebral-fragility-fracture-experience-of-a-uk-fracture-liaison-service
#17
Aina Capdevila Reniu, Terence Ong, Syed Ajmal, Opinder Sahota
Twenty-five percent of patients with a non-hip non-vertebral fragility fracture have an undiagnosed vertebral fracture detected by vertebral fracture assessment during bone densitometric assessment. The prevalence of an undiagnosed vertebral fracture is higher in older people, and they are more likely to have multiple vertebral fractures. PURPOSE: Most vertebral fragility fractures (VFF) have no history of trauma. Vertebral fracture assessment (VFA) during dual energy x-ray absorptiometry (DXA) can be used to detect these VFFs...
December 2017: Archives of Osteoporosis
https://www.readbyqxmd.com/read/28175979/mind-the-treatment-gap-a-global-perspective-on-current-and-future-strategies-for-prevention-of-fragility-fractures
#18
REVIEW
N C W Harvey, E V McCloskey, P J Mitchell, B Dawson-Hughes, D D Pierroz, J-Y Reginster, R Rizzoli, C Cooper, J A Kanis
This narrative review considers the key challenges facing healthcare professionals and policymakers responsible for providing care to populations in relation to bone health. These challenges broadly fall into four distinct themes: (1) case finding and management of individuals at high risk of fracture, (2) public awareness of osteoporosis and fragility fractures, (3) reimbursement and health system policy and (4) epidemiology of fracture in the developing world. Findings from cohort studies, randomised controlled trials, systematic reviews and meta-analyses, in addition to current clinical guidelines, position papers and national and international audits, are summarised, with the intention of providing a prioritised approach to delivery of optimal bone health for all...
May 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28110293/increased-use-of-oral-anticoagulants-in-patients-with-atrial-fibrillation-temporal-trends-from-2005-to-2015-in-denmark
#19
Kasper Gadsbøll, Laila Staerk, Emil Loldrup Fosbøl, Caroline Sindet-Pedersen, Anna Gundlund, Gregory Y H Lip, Gunnar Hilmar Gislason, Jonas Bjerring Olesen
AIM: The aim of this study is to examine temporal trends in the use oral anticoagulants (OAC) as stroke prophylaxis in patients with atrial fibrillation (AF) and to examine factors associated with OAC initiation. METHODS AND RESULTS: From Danish nationwide registries, we identified patients diagnosed with AF at Danish hospitals and outpatient clinics between January 2005 and June 2015. OAC initiation was assessed from prescription fills ±180 days from date of AF diagnosis...
January 21, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28108441/child-with-multiple-fractures-a-rare-presentation-of-a-common-disease
#20
Filipa Dias Costa, Carla Maia, Susana Almeida, Ricardo Ferreira
Bone fractures are not uncommon in paediatric age. However, when recurrent, an underlying clinical condition must not be excluded. We describe the case of a boy aged 7 years, referred for investigation of recurrent bone fractures. Personal and family histories were unremarkable. Physical examination was normal. Almost all primary bone disorders were excluded. Additional laboratory investigations ruled out the majority of secondary causes of bone fragility. Coeliac disease (CD) serologies, however, were positive, and duodenal biopsies confirmed this diagnosis (Marsh III B)...
January 20, 2017: BMJ Case Reports
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