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https://www.readbyqxmd.com/read/29137106/trabecular-bone-score-as-a-supplementary-tool-for-the-discrimination-of-osteoporotic-fractures-in-postmenopausal-women-with-rheumatoid-arthritis
#1
Yong Jun Choi, Yoon-Sok Chung, Chang-Hee Suh, Ju-Yang Jung, Hyoun-Ah Kim
Rheumatoid arthritis (RA) is a risk factor for bone fragility, and its effect on fracture risk is independent of bone mineral density (BMD). The trabecular bone score (TBS) is a new indirect parameter of bone quality. In this study, BMD and the TBS were compared between female postmenopausal RA patients with and those without vertebral fractures (VFs).This study had a cross-sectional design. Two hundred seventy-nine postmenopausal women with RA aged 50 years or older were included in this study. TBS measurements were performed on the same vertebrae as those for the BMD measurements...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29106548/comprehensive-geriatric-assessment-for-identifying-older-people-at-risk-of-hip-fracture-cross-sectional-study-with-comparative-group
#2
Raquel Ramírez-Martín, María Victoria Castell Alcalá, Teresa Alarcón, Rocío Queipo, Peggy Paola Ríos Germán, Ángel Otero Puime, Juan Ignacio González-Montalvo
Background: Hip fracture (HF) is by far the most common serious fragility fracture. Its care is a major challenge to all healthcare systems. Aim: To determine whether there are characteristics of older people identified via comprehensive geriatric assessment (CGA) that help identify those with an increased risk of HF. Methods: The demographic, functional, cognitive and nutritional data of a cohort of patients admitted for acute HF were compared with those of a population cohort representing community-dwelling older people in the same urban district without HF...
July 4, 2017: Family Practice
https://www.readbyqxmd.com/read/29084183/dietary-magnesium-may-be-protective-for-aging-of-bone-and-skeletal-muscle-in-middle-and-younger-older-age-men-and-women-cross-sectional-findings-from-the-uk-biobank-cohort
#3
Ailsa A Welch, Jane Skinner, Mary Hickson
Although fragility fractures, osteoporosis, sarcopenia, and frailty are becoming more prevalent in our aging society the treatment options are limited and preventative strategies are needed. Despite magnesium being integral to bone and muscle physiology, the relationship between dietary magnesium and skeletal muscle and bone health has not been investigated concurrently to date. We analysed cross-sectional associations between dietary magnesium and skeletal muscle mass (as fat free mass-FFM), grip strength, and bone density (BMD) in 156,575 men and women aged 39-72 years from the UK Biobank cohort...
October 30, 2017: Nutrients
https://www.readbyqxmd.com/read/29075333/the-impact-of-type-2-diabetes-on-bone-metabolism
#4
REVIEW
Claudia Pinheiro Sanches, Andre Gustavo Daher Vianna, Fellype de Carvalho Barreto
Diabetes complications and osteoporotic fractures are two of the most important causes of morbidity and mortality in older patients and share many features including genetic susceptibility, molecular mechanisms, and environmental factors. Type 2 diabetes mellitus (T2DM) compromises bone microarchitecture by inducing abnormal bone cell function and matrix structure, with increased osteoblast apoptosis, diminished osteoblast differentiation, and enhanced osteoclast-mediated bone resorption. The linkage between these two chronic diseases creates a possibility that certain antidiabetic therapies may affect bone quality...
2017: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/29052793/comparison-of-fracture-risk-assessment-tools-in-older-men-without-prior-hip-or-spine-fracture-the-mros-study
#5
Margaret L Gourlay, Victor S Ritter, Jason P Fine, Robert A Overman, John T Schousboe, Peggy M Cawthon, Eric S Orwoll, Tuan V Nguyen, Nancy E Lane, Steven R Cummings, Deborah M Kado, Jodi A Lapidus, Susan J Diem, Kristine E Ensrud
Femoral neck bone mineral density (BMD), age plus femoral neck BMD T score, and three externally generated fracture risk tools had similar accuracy to identify older men who developed osteoporotic fractures. Risk tools with femoral neck BMD performed better than those without BMD. The externally developed risk tools were poorly calibrated. INTRODUCTION: We compared the performance of fracture risk assessment tools in older men, accounting for competing risks including mortality. METHODS: A comparative ROC curve analysis assessed the ability of the QFracture, FRAX® and Garvan fracture risk tools, and femoral neck bone mineral density (BMD) T score with or without age to identify incident fracture in community-dwelling men aged 65 years or older (N = 4994) without hip or clinical vertebral fracture or antifracture treatment at baseline...
October 20, 2017: Archives of Osteoporosis
https://www.readbyqxmd.com/read/29049519/association-of-bone-mineral-density-with-the-risk-of-intracranial-aneurysm
#6
Yong-Won Shin, Kyung-Il Park, Jangsup Moon, Soon-Tae Lee, Kon Chu, Sang Kun Lee, Jae-Kyu Roh, Keun-Hwa Jung
Importance: Disruption of extracellular matrix integrity is critically involved in both intracranial aneurysm and bone fragility. Furthermore, both intracranial aneurysm and osteoporosis have a female predominance, and sex hormones are considered to affect this discrepancy. Objective: To evaluate the association between bone mineral density and intracranial aneurysm. Design, Setting, and Participants: A cross-sectional study conducted with 14 328 patients who underwent brain magnetic resonance angiography and bone mineral densitometry as a part of a health examination at a specialized center for comprehensive health examination in Seoul, the largest metropolitan area in the Republic of Korea, between December 2004 and November 2015...
October 16, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/29023743/oral-health-for-an-ageing-population-the-importance-of-a-natural-dentition-in-older-adults
#7
Frauke Müller, Yoshihiro Shimazaki, Febronia Kahabuka, Martin Schimmel
Despite progress in dentistry, tooth loss in old age is still a reality, even more so in long-term-care residents. However, recent trends indicate that natural teeth are lost later in life. Functional decline and age-related pathologies have to be considered in oral health care for this vulnerable population. Retaining and restoring teeth and oral function in elders is important. Tooth loss significantly impairs masticatory performance, which cannot be fully restored by prosthodontic means. Hence an unconscious change in food intake occurs, often involving malnutrition and withdrawal from common meals...
September 2017: International Dental Journal
https://www.readbyqxmd.com/read/29021637/physical-frailty-and-fitness-of-older-driver
#8
Maria Helena Lenardt, Clovis Cechinel, Maria Angelica Binotto, Nathalia Hammerschmidt Kolb Carneiro, Tânia Maria Lourenço
AIM: to analyze the association between physical frailty and the results of fitness capacity exams for driving vehicles among elder Brazilians. METHODS: this is a cross sectional study, performed in traffic medicine clinics of the city of Curitiba (Brazil). The data was collected through the physical frailty tests, the use of a structured questionnaire, and searches on the records of the Brazilian National Register of Qualified Drivers.To analyze the information, the authors used descriptive statistics and non-parametrical tests...
June 30, 2017: Colombia Médica: CM
https://www.readbyqxmd.com/read/28986305/high-throughput-biosorter-quantification-of-relative-mitochondrial-content-and-membrane-potential-in-living-caenorhabditis-elegans
#9
Young Joon Kwon, Sujay Guha, Florin Tuluc, Marni J Falk
Mitochondrial respiratory chain disease is caused by a wide range of individually rare genetic disorders that impair cellular energy metabolism. While fluorescence microscopy analysis of nematodes fed MitoTracker Green (MTG) and tetramethylrhodamine ethyl ester (TMRE) can reliably quantify relative mitochondrial density and membrane potential, respectively, in C. elegans, it is a tedious process with limitations in the number and age of animals that can be studied. A novel, large particle, flow cytometry-based method reported here accelerates and automates the relative quantitation of mitochondrial physiology in nematode populations...
October 3, 2017: Mitochondrion
https://www.readbyqxmd.com/read/28974557/utility-of-dxa-screening-for-diagnosis-of-osteoporosis-in-us-veterans-aged-70-years-and-older
#10
Joanna Khatib, Kim Stote, Aidar R Gosmanov
Dual energy X-ray absorptiometry (DXA) is recommended for osteoporosis screening in men aged 70 years and older but supportive data is limited. The aim of this study was to determine the efficacy of DXA for the diagnosis of increased fragility in this group of subjects. We retrospectively identified men aged 70 years and older without prior history of fracture and/or conditions predisposing to low bone mineral density (BMD) who attended the VA endocrinology clinic and performed DXA for osteoporosis screening...
October 2, 2017: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://www.readbyqxmd.com/read/28956152/which-factors-are-independent-predictors-of-early-recovery-of-mobility-in-the-older-adults-population-after-hip-fracture-a-cohort-prognostic-study
#11
Mattia Morri, Cristiana Forni, Maura Marchioni, Elena Bonetti, Francesca Marseglia, Andrea Cotti
INTRODUCTION: The aim of the present study was to identify all factors that might influence the short-term recovery of mobility in older adults' patients after hip surgery. METHODS: A prospective cohort prognostic study was carried out. The study enrolled all consecutive patients aged 65 years or over admitted for hip fracture due to fragility. Patients were monitored from their admission into the emergency department of the hospital, until their discharge. The level of mobility was measured by the ILOA scale, administered during the 6th day of hospitalisation...
September 27, 2017: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/28941155/women-who-carry-a-fragile-x-premutation-are-biologically-older-than-noncarriers-as-measured-by-telomere-length
#12
Igor Albizua, Benjamin L Rambo-Martin, Emily G Allen, Weiya He, Ashima S Amin, Stephanie L Sherman
Women who carry a fragile X premutation, defined as having 55-200 unmethylated CGG repeats in the 5' UTR of the X-linked FMR1 gene, have a 20-fold increased risk for primary ovarian insufficiency (FXPOI). We tested the hypothesis that women with a premutation + FXPOI have shorter telomeres than those without FXPOI because they are "biologically older." Using linear regression, we found that women carrying a premutation (n = 172) have shorter telomeres and hence, are "biologically older" than women carrying the normal size allele (n = 81)...
November 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/28930900/retrospective-evaluation-of-the-impact-of-a-geriatric-trauma-institute-on-fragility-hip-fracture-patient-outcomes
#13
Elizabeth D Katrancha, Jami Zipf, Nancy Abrahams, Richard Schroeder
BACKGROUND: Fragility hip fractures occur in the older than 65-year population at an alarming rate. It is estimated that 260,000 hip fractures occur annually. Patient outcomes following hip fractures are devastating. One of every 5 patients dies within 1 year of injury, and 1 of 3 remains in a nursing home for years after the injury. Published literature recommends an interdisciplinary approach to caring for hip-fractured patients and expediting surgery to improve outcomes. PURPOSE: The purpose of this study was to retrospectively evaluate the impact of the Geriatric Trauma Institute (GTI) on fragility hip fracture patient outcomes...
September 2017: Orthopaedic Nursing
https://www.readbyqxmd.com/read/28929525/diabetes-and-deficits-in-cortical-bone-density-microarchitecture-and-bone-size-framingham-hr-pqct-study
#14
Elizabeth J Samelson, Serkalem Demissie, L Adrienne Cupples, Xiaochun Zhang, Hanfei Xu, Ching-Ti Liu, Steven K Boyd, Robert R McLean, Kerry E Broe, Douglas P Kiel, Mary L Bouxsein
Older adults with type 2 diabetes (T2D) tend to have normal or greater areal bone mineral density (aBMD), as measured by DXA, than those who do not have diabetes (non-T2D). Yet risk of fracture is higher in T2D, including 40% to 50% increased hip fracture risk. We used HR-pQCT to investigate structural mechanisms underlying skeletal fragility in T2D. We compared cortical and trabecular bone microarchitecture, density, bone area, and strength in T2D and non-T2D. In secondary analyses we evaluated whether associations between T2D and bone measures differed according to prior fracture, sex, and obesity...
September 20, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/28919366/prevalence-and-risk-factors-for-fragility-fracture-in-systemic-mastocytosis
#15
Yannick Degboé, Marine Eischen, Delphine Nigon, Pol-André Apoil, Claire Mailhol, Emilie Tournier, Camille Laurent, Katia Hanssens, Olivier Hermine, Carle Paul, Michel Laroche, Cristina Bulai-Livideanu
OBJECTIVES: Systemic mastocytosis (SM) is characterized by the accumulation of mast cells in tissues other than the skin. Bone involvement although frequent has not been thoroughly evaluated. Primary objective was to determine risk factors associated with fragility fractures (FF) in SM. Secondary objectives were to evaluate the ability of bone marrow tryptase (BMT) level to identify patients with FF, and to describe bone involvement in SM. METHODS: We analyzed retrospectively all consecutive patients seen in our expert center, with a diagnosis of SM according to the 2001 WHO criteria, and with complete bone assessment...
September 14, 2017: Bone
https://www.readbyqxmd.com/read/28906354/the-influence-of-renal-dialysis-and-hip-fracture-sites-on-the-10-year-mortality-of-elderly-hip-fracture-patients-a-nationwide-population-based-observational-study
#16
Li-Wei Hung, Yi-Ting Hwang, Guey-Shiun Huang, Cheng-Chih Liang, Jinn Lin
Hip fractures in older people requiring dialysis are associated with high mortality. Our study primarily aimed to evaluate the specific burden of dialysis on the mortality rate following hip fracture. The secondary aim was to clarify the effect of the fracture site on mortality. A retrospective cohort study was conducted using Taiwan's National Health Insurance Research Database to analyze nationwide health data regarding dialysis and non-dialysis patients ≥65 years who sustained a first fragility-related hip fracture during the period from 2001 to 2005...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28884422/less-strict-intervention-thresholds-for-the-frax-and-tbs-adjusted-frax-predict-clinical-fractures-in-osteopenic-postmenopausal-women-with-no-prior-fractures
#17
Martin Kužma, Didier Hans, Tomáš Koller, Eva Némethová, Peter Jackuliak, Zdenko Killinger, Heinrich Resch, Juraj Payer
Little is known about the clinical relevance of treating post-menopausal women with no prior history of fragility fracture and bone mineral densities (BMD) within the osteopenic range. In recent years, in addition to BMD and FRAX fracture probability assessments, a surrogate measure of bone micro-architecture quality, called the trabecular bone score (TBS), has been proven to predict future fragility fractures independently of both BMD and the FRAX. In this retrospective analysis of a follow-up study, we compared three risk assessment instruments-the FRAX, the TBS, and a TBS-adjusted FRAX score-in their ability, to predict future fragility fractures over a minimum of five years of follow-up among post-menopausal osteopenic women with no prior fragility fractures...
September 7, 2017: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/28870623/development-of-fracture-liaison-services-what-have-we-learned
#18
Kate E Shipman, Alison Doyle, Hilary Arden, Tim Jones, Neil J Gittoes
Due to dramatic improvements in life expectancy we are seeing a rapidly growing population of older people. Increasing frailty and susceptibility to fragility fractures are becoming pressing issues for both the individuals that suffer them as well as society, through pressures on health and social care budgets. The success of fracture liaison services, co-ordinated programmes enhancing the management of the fracture, osteoporosis, frailty and falls risk, is undisputed. To achieve optimal outcomes, however, it is important to have a standardisation of design, scope and structure of the service...
September 1, 2017: Injury
https://www.readbyqxmd.com/read/28842782/optimal-post-operative-radiation-after-soft-tissue-sarcoma-resection-is-achieved-in-less-than-two-thirds-of-cases
#19
Laurent Casabianca, Sarah Kreps, Sylvie Helfre, Martin Housset, Philippe Anract, David J Biau
PURPOSE: Local control of soft tissue sarcomas frequently involves adjuvant radiation to the surgical resection. When opting for post-operative radiation, care should be taken that radiation is started within some reasonable time after the surgery. We were interested to the proportion of patients who did not recieve optimal post-operative radiation and the variables associated. METHODS: We retrospectively analyzed a series of 77 patients operated on for an extremity soft-tissue sarcoma and due for post-operative radiotherapy...
August 25, 2017: International Orthopaedics
https://www.readbyqxmd.com/read/28838299/peculiarities-of-feline-hyperadrenocorticism-update-on-diagnosis-and-treatment
#20
Lara A Boland, Vanessa R Barrs
Practical relevance: Hyperadrenocorticism (HAC) is a relatively uncommon endocrinopathy of older cats, with a mean age at diagnosis of 10 years. In addition to pituitary-dependent and adrenal-dependent hypercortisolism, clinical signs of HAC can result from adrenal sex steroid-producing tumours. Clinical challenges: While HAC in cats has many similarities to canine HAC, there are key differences in presentation, diagnosis and response to therapy. Most, but not all, cats with HAC have concurrent diabetes mellitus, which is often insulin resistant...
September 2017: Journal of Feline Medicine and Surgery
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