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https://www.readbyqxmd.com/read/27936427/an-observed-rise-in-%C3%AE-hydroxybutyrate-associated-deaths-in-london-evidence-to-suggest-a-possible-link-with-concomitant-rise-in-chemsex
#1
Joanna Hockenhull, Kevin G Murphy, Sue Paterson
BACKGROUND: Gamma-hydroxybutyrate (GHB) is the drug most linked to acute harm out of those used in chemsex, the incidence of which is reported to be increasing. However, there have been few systematic studies of the harms associated with GHB use. We investigated GHB-associated deaths from London coroners' jurisdictions between 2011 and 2015. METHODS: Blood and urine samples were collected by pathologists and submitted for toxicological analysis at the request of coroners...
December 2, 2016: Forensic Science International
https://www.readbyqxmd.com/read/27925557/-don-t-be-afraid-of-failure
#2
(no author information available yet)
Venetia Wynter-Blyth has worked in oncology for 15 years. She spent 12 years as an upper gastrointestinal (GI) clinical nurse specialist before taking up her current post as Macmillan nurse consultant in upper GI cancers at Imperial College Healthcare NHS Trust in London. She was named RCN Nurse of the Year 2016 for creating PREPARE, a holistic 'prehabilitation' self-management programme for people with cancer who require surgery.
December 7, 2016: Nursing Standard
https://www.readbyqxmd.com/read/27923309/-make-your-opportunities
#3
Layla Haidrani
What is your job? I am a clinical research nurse for neurosurgery, emergency and trauma at Imperial College Healthcare NHS Trust, London. My role involves supporting research in neurosurgery, emergency and trauma care. I offer guidance at all stages of the research process, from project conception to output.
December 7, 2016: Emergency Nurse: the Journal of the RCN Accident and Emergency Nursing Association
https://www.readbyqxmd.com/read/27861025/vaccines-in-pregnancy-matimms
#4
(no author information available yet)
This app was developed by researchers and clinicians at Imperial College London and Imperial College Healthcare NHS Trust after concern about the low uptake of vaccines among pregnant women.
November 2, 2016: Nursing Standard
https://www.readbyqxmd.com/read/27805046/natural-resistance-to-meningococcal-disease-related-to-cfh-loci-meta-analysis-of-genome-wide-association-studies
#5
Federico Martinón-Torres, Eileen Png, Chiea Chuen Khor, Sonia Davila, Victoria J Wright, Kar Seng Sim, Ana Vega, Laura Fachal, David Inwald, Simon Nadel, Enitan D Carrol, Nazareth Martinón-Torres, Sonia Marcos Alonso, Angel Carracedo, Elvira Morteruel, Julio López-Bayón, Andrés Concha Torre, Cristina Calvo Monge, Pilar Azcón González de Aguilar, Elisabeth Esteban Torné, María Del Carmen Martínez-Padilla, José María Martinón-Sánchez, Michael Levin, Martin L Hibberd, Antonio Salas
Meningococcal disease (MD) remains an important infectious cause of life threatening infection in both industrialized and resource poor countries. Genetic factors influence both occurrence and severity of presentation, but the genes responsible are largely unknown. We performed a genome-wide association study (GWAS) examining 5,440,063 SNPs in 422 Spanish MD patients and 910 controls. We then performed a meta-analysis of the Spanish GWAS with GWAS data from the United Kingdom (combined cohorts: 897 cases and 5,613 controls; 4,898,259 SNPs)...
November 2, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27776147/astrocytic-%C3%AE-2-adrenergic-receptor-gene-deletion-affects-memory-in-aged-mice
#6
Cathy Joanna Jensen, Frauke Demol, Romy Bauwens, Ron Kooijman, Ann Massie, Agnès Villers, Laurence Ris, Jacques De Keyser
In vitro and in vivo studies suggest that the astrocytic adrenergic signalling enhances glycogenolysis which provides energy to be transported to nearby cells and in the form of lactate. This energy source is important for motor and cognitive functioning. While it is suspected that the β2-adrenergic receptor on astrocytes might contribute to this energy balance, it has not yet been shown conclusively in vivo. Inducible astrocyte specific β2-adrenergic receptor knock-out mice were generated by crossing homozygous β2-adrenergic receptor floxed mice (Adrb2flox) and mice with heterozygous tamoxifen-inducible Cre recombinase-expression driven by the astrocyte specific L-glutamate/L-aspartate transporter promoter (GLAST-CreERT2)...
2016: PloS One
https://www.readbyqxmd.com/read/27703670/opportunities-and-considerations-for-visualising-neuroimaging-data-on-very-large-displays
#7
Matthew B Wall, David Birch, May Y Yong
Neuroimaging experiments can generate impressive volumes of data and many images of the results. This is particularly true of multi-modal imaging studies that use more than one imaging technique, or when imaging is combined with other assessments. A challenge for these studies is appropriate visualisation of results in order to drive insights and guide accurate interpretations. Next-generation visualisation technology therefore has much to offer the neuroimaging community. One example is the Imperial College London Data Observatory; a high-resolution (132 megapixel) arrangement of 64 monitors, arranged in a 313 degree arc, with a 6 metre diameter, powered by 32 rendering nodes...
2016: F1000Research
https://www.readbyqxmd.com/read/27664209/novel-circulating-placental-markers-prokineticin-1-soluble-fms-like-tyrosine-kinase-1-soluble-endoglin-and-placental-growth-factor-and-association-with-late-miscarriage
#8
C N Jayasena, A Abbara, A N Comninos, S Narayanaswamy, J Gonzalez Maffe, C Izzi-Engbeaya, J Oldham, T T M Lee, Z Sarang, Z Malik, M K Dhanjal, C Williamson, L Regan, S R Bloom, W S Dhillo
STUDY QUESTION: Are novel circulating placental markers prokineticin-1 (PK-1), soluble fms-like tyrosine kinase-1 (sFlt-1), soluble endoglin (sEng) and placental growth factor (PlGF) associated with late miscarriage in asymptomatic first trimester pregnant women? SUMMARY ANSWER: Increased serum sFlt-1 or PlGF, but not sEng or PK-1, were significantly associated with reduced miscarriage risk after adjustment for age, BMI, gestational age, smoking and blood pressure...
September 22, 2016: Human Reproduction
https://www.readbyqxmd.com/read/27488944/an-evaluation-of-the-effect-of-an-angiotensin-converting-enzyme-inhibitor-on-the-growth-rate-of-small-abdominal-aortic-aneurysms-a-randomised-placebo-controlled-trial-aardvark
#9
Gaia Kiru, Colin Bicknell, Emanuela Falaschetti, Janet Powell, Neil Poulter
BACKGROUND: Although data are inconsistent, angiotensin-converting enzyme inhibitors (ACE-Is) have been associated with a reduced incidence of abdominal aortic aneurysm (AAA) rupture in analysis of administrative databases. OBJECTIVES: (1) To investigate whether or not the ACE-I perindopril (Coversyl arginine, Servier) reduces small AAA growth rate and (2) to evaluate blood pressure (BP)-independent effects of perindopril on small AAA growth and to compare the repeatability of measurement of internal and external aneurysm diameters...
July 2016: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/27485937/paediatric-eye-services-how-much-of-the-workload-is-amblyopia-related
#10
Catherine E Stewart, Shaheen Shah, Siobhan Wren, Clare J Roberts
AIMS: The proportion of patients seen by the paediatric eye service that attend for reasons related to amblyopia has not been quantified. The purpose of this study was to quantify the proportion of patients seen in the paediatric eye service attending for reasons related to amblyopia. METHODS: Records of all eye appointments of children attending the Hillingdon Hospitals NHS Foundation Trust and St Mary's Hospital Imperial College Healthcare NHS Trust over one month in 2009 were examined to determine the diagnosis and reason for attendance...
September 2016: Strabismus
https://www.readbyqxmd.com/read/27484970/new-patient-reported-experience-measure-for-children-with-allergic-disease-development-validation-and-results-from-integrated-care
#11
C Gore, R Griffin, T Rothenberg, A Tallett, B Hopwood, S Sizmur, C O'Keeffe, J O Warner
OBJECTIVES: To develop and validate a new allergy-specific patient-reported experience measure (PREM) for children and their parents, and to collect feedback in an integrated care setting. DESIGN: Two allergy-specific PREMs were produced using focus groups, cognitive testing, two prospective validation studies (collaboration: Royal College of Paediatrics and Child Health, Picker Institute Europe, Imperial College/London): 'Your Allergy Care', for children aged 8-16 years; 'Your Child's Allergy Care', for parents of children aged 0-7 years...
October 2016: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/27468335/impact-of-clinical-and-procedural-factors-upon-c-reactive-protein-dynamics-following-transcatheter-aortic-valve-implantation
#12
Neil Ruparelia, Vasileios F Panoulas, Angela Frame, Ben Ariff, Nilesh Sutaria, Michael Fertleman, Jonathan Cousins, Jon Anderson, Colin Bicknell, Andrew Chukwuemeka, Sayan Sen, Iqbal S Malik, Antonio Colombo, Ghada W Mikhail
AIM: To determine the effect of procedural and clinical factors upon C reactive protein (CRP) dynamics following transcatheter aortic valve implantation (TAVI). METHODS: Two hundred and eight consecutive patients that underwent transfemoral TAVI at two hospitals (Imperial, College Healthcare NHS Trust, Hammersmith Hospital, London, United Kingdom and San Raffaele Scientific Institute, Milan, Italy) were included. Daily venous plasma CRP levels were measured for up to 7 d following the procedure (or up to discharge)...
July 26, 2016: World Journal of Cardiology
https://www.readbyqxmd.com/read/27458619/cardiopulse-leaders-in-cardiovascular-medicine-of-today-professor-david-wood-imperial-college-london
#13
Mark Nicholls
No abstract text is available yet for this article.
February 7, 2016: European Heart Journal
https://www.readbyqxmd.com/read/27412108/protocol-for-a-randomised-control-trial-of-methylnaltrexone-for-the-treatment-of-opioid-induced-constipation-and-gastrointestinal-stasis-in-intensive-care-patients-motion
#14
Parind B Patel, Stephen J Brett, David O'Callaghan, Aisha Anjum, Mary Cross, Jane Warwick, Anthony C Gordon
INTRODUCTION: Gastrointestinal dysmotility and constipation are common problems in intensive care patients. The majority of critical care patients are sedated with opioids to facilitate tolerance of endotracheal tubes and mechanical ventilation, which inhibit gastrointestinal motility and lead to adverse outcomes. Methylnaltrexone is a peripheral opioid antagonist that does not cross the blood-brain barrier and can reverse the peripheral side effects of opioids without affecting the desired central properties...
2016: BMJ Open
https://www.readbyqxmd.com/read/27342755/a-virtual-reality-training-curriculum-for-laparoscopic-colorectal-surgery
#15
Laura Beyer-Berjot, Stéphane Berdah, Daniel A Hashimoto, Ara Darzi, Rajesh Aggarwal
OBJECTIVE: Training within a competency-based curriculum (CBC) outside the operating room enhances performance during real basic surgical procedures. This study aimed to design and validate a virtual reality CBC for an advanced laparoscopic procedure: sigmoid colectomy. DESIGN: This was a multicenter randomized study. Novice (surgeons who had performed <5 laparoscopic colorectal resections as primary operator), intermediate (between 10 and 20), and experienced surgeons (>50) were enrolled...
November 2016: Journal of Surgical Education
https://www.readbyqxmd.com/read/27293773/the-impact-of-the-doh-commissioning-for-quality-and-innovation-incentive-on-the-success-of-venous-thromboembolism-risk-assessment-in-hospitalised-patients-a-single-institution-experience-in-a-quality-outcome-improvement-over-a-4-year-cycle
#16
Abdul Shlebak, Polly Sandhu, Vernisha Ali, Garth Jones, Christopher Baker
OBJECTIVES: To i) demonstrate compliance with the Commissioning for Quality and Innovation for venous thromboembolism risk assessment ii) to undertake root cause analysis of Hospital Acquired Thrombosis and to investigate its impact on quality of care. DESIGN: Prospective monitoring of all admissions. SETTING: Imperial College Healthcare Hospitals, London. PARTICIPANTS: All Hospital Provider Spells as defined on the NHS Data Model and Dictionary...
June 2016: JRSM Open
https://www.readbyqxmd.com/read/27284027/the-foundry-the-dna-synthesis-and-construction-foundry-at-imperial-college
#17
REVIEW
Stephen Chambers, Richard Kitney, Paul Freemont
The establishment of a DNA synthesis and construction foundry at Imperial College in London heralds a new chapter in the development of synthetic biology to meet new global challenges. The Foundry employs the latest technology to make the process of engineering biology easier, faster and scalable. The integration of advanced software, automation and analytics allows the rapid design, build and testing of engineered organisms.
June 15, 2016: Biochemical Society Transactions
https://www.readbyqxmd.com/read/27231741/patient-safety-the-next-15-years-part-2
#18
John Tingle
No abstract text is available yet for this article.
May 26, 2016: British Journal of Nursing: BJN
https://www.readbyqxmd.com/read/27224651/understanding-the-influence-of-genes-diet-and-occupation-on-respiratory-health
#19
André F S Amaral, Vanessa Garcia Larsen, Sara De Matteis, Cosetta Minelli
No abstract text is available yet for this article.
July 15, 2016: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/27190092/leadership-behaviours-and-healthcare-research-performance-prospective-correlational-study
#20
Vanash M Patel, Hutan Ashrafian, Chukwudi Uzoho, Nikolaos Nikiteas, Pietro Panzarasa, Nick Sevdalis, Ara Darzi, Thanos Athanasiou
OBJECTIVES: The aims of the study were to determine whether differences in leadership self-perception/behaviour in healthcare researchers may influence research performance and to evaluate whether certain leadership characteristics are associated with enhanced leadership efficiency in terms of motivation, effectiveness and satisfaction. DESIGN AND PARTICIPANTS: All Faculty of Medicine Professors at Imperial College London (n=215) were sent the Multifactor Leadership Questionnaire (MLQ) Self form as a means of evaluating self-perception of leadership behaviours...
May 16, 2016: Postgraduate Medical Journal
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