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https://www.readbyqxmd.com/read/29728447/investigating-the-association-of-alerts-from-a-national-mortality-surveillance-system-with-subsequent-hospital-mortality-in-england-an-interrupted-time-series-analysis
#1
Elizabeth Cecil, Alex Bottle, Aneez Esmail, Samantha Wilkinson, Charles Vincent, Paul P Aylin
OBJECTIVE: To investigate the association between alerts from a national hospital mortality surveillance system and subsequent trends in relative risk of mortality. BACKGROUND: There is increasing interest in performance monitoring in the NHS. Since 2007, Imperial College London has generated monthly mortality alerts, based on statistical process control charts and using routinely collected hospital administrative data, for all English acute NHS hospital trusts...
May 4, 2018: BMJ Quality & Safety
https://www.readbyqxmd.com/read/29723428/dulcie-coleman-a-pioneer-of-cytology-in-the-uk-and-europe
#2
EDITORIAL
Amanda Herbert
We sadly announce the death earlier this year of Professor Dulcie V Coleman, the driving force behind the publication of Cytopathology in 1990 and pioneer of cytology in the UK and throughout Europe (Figure 1). She died peacefully in Naples, Florida on Sunday 4th February 2018 surrounded by her family including her husband of 60 years (Jack Poznansky), their four children and two of their 13 grandchildren several of whom contributed to her academic work and publications. She had moved to Florida to be nearer much of her family but returned regularly to continue her work at Imperial College...
May 3, 2018: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://www.readbyqxmd.com/read/29605206/the-100-most-influential-publications-in-asthma-from-1960-to-2017-a-bibliometric-analysis
#3
REVIEW
Yulan Qu, Chen Zhang, Zhenli Hu, Sha Li, Chen Kong, Yunye Ning, Yan Shang, Chong Bai
BACKGROUND: The area of asthma medicine has produced a large volume of important clinical and scientific papers that can be found in those most influential journals. The purpose of our study was to identify the 100 most cited papers in asthma research and to analyze their characteristics. METHODS: We used the Institute for Scientific Information Web of Knowledge Database to identify the most frequently cited articles published from 1960 to December 2017. Original articles and reviews were included in the study...
April 2018: Respiratory Medicine
https://www.readbyqxmd.com/read/29569969/implementation-of-team-based-learning-on-a-large-scale-three-factors-to-keep-in-mind
#4
Preman Rajalingam, Jerome I Rotgans, Nabil Zary, Michael Alan Ferenczi, Paul Gagnon, Naomi Low-Beer
Team-based learning (TBL) is a structured form of small group learning that can be scaled up for delivery in large classes. The principles of successful TBL implementation are well established. TBL has become widely practiced in medical schools, but its use is typically limited to certain courses or parts of courses. Implementing TBL on a large scale, across different courses and disciplines, is the next logical step. The Lee Kong Chian School of Medicine (LKCMedicine), a partnership between Nanyang Technological University, Singapore and Imperial College London, admitted its first students in 2013...
March 23, 2018: Medical Teacher
https://www.readbyqxmd.com/read/29568516/development-of-a-patient-centred-intervention-to-improve-knowledge-and-understanding-of-antibiotic-therapy-in-secondary-care
#5
Timothy M Rawson, Luke S P Moore, Enrique Castro-Sanchez, Esmita Charani, Bernard Hernandez, Vivian Alividza, Fran Husson, Christofer Toumazou, Raheelah Ahmad, Pantelis Georgiou, Alison H Holmes
Background: We developed a personalised antimicrobial information module co-designed with patients. This study aimed to evaluate the potential impact of this patient-centred intervention on short-term knowledge and understanding of antimicrobial therapy in secondary care. Methods: Thirty previous patients who had received antibiotics in hospital within 12 months were recruited to co-design an intervention to promote patient engagement with infection management...
2018: Antimicrobial Resistance and Infection Control
https://www.readbyqxmd.com/read/29431856/cerebral-embolization-silent-cerebral-infarction-and-neurocognitive-decline-after-thoracic-endovascular-aortic-repair
#6
A H Perera, N Rudarakanchana, L Monzon, C D Bicknell, B Modarai, O Kirmi, T Athanasiou, M Hamady, R G Gibbs
BACKGROUND: Silent cerebral infarction is brain injury detected incidentally on imaging; it can be associated with cognitive decline and future stroke. This study investigated cerebral embolization, silent cerebral infarction and neurocognitive decline following thoracic endovascular aortic repair (TEVAR). METHODS: Patients undergoing elective or emergency TEVAR at Imperial College Healthcare NHS Trust and Guy's and St Thomas' NHS Foundation Trust between January 2012 and April 2015 were recruited...
March 2018: British Journal of Surgery
https://www.readbyqxmd.com/read/29360625/meeting-report-shining-light-on-septins
#7
REVIEW
Fabrice Caudron, Smita Yadav
Septins are enigmatic proteins; they bind GTP and assemble together like molecular Lego blocks to form intracellular structures of varied shapes such as filaments, rings and gauzes. To shine light on the biological mysteries of septin proteins, leading experts in the field came together for the European Molecular Biology Organization (EMBO) workshop held from 8-11 October 2017 in Berlin. Organized by Helge Ewers (Freie Universität, Berlin, Germany) and Serge Mostowy (Imperial College, London, UK), the workshop convened at the Harnack-Haus, a historic hub of scientific discourse run by the Max Planck Society...
January 8, 2018: Journal of Cell Science
https://www.readbyqxmd.com/read/29311660/defining-phenotypes-in-diabetic-nephropathy-a-novel-approach-using-a-cross-sectional-analysis-of-a-single-centre-cohort
#8
Rosa M Montero, Athula Herath, Ashfaq Qureshi, Ehsanollah Esfandiari, Charles D Pusey, Andrew H Frankel, Frederick W K Tam
The global increase in Diabetes Mellitus (DM) has led to an increase in DM-Chronic Kidney Disease (DM-CKD). In this cross-sectional observational study we aimed to define phenotypes for patients with DM-CKD that in future may be used to individualise treatment We report 4 DM-CKD phenotypes in 220 patients recruited from Imperial College NHS Trust clinics from 2004-2012. A robust principal component analysis (PCA) was used to statistically determine clusters with phenotypically different patients. 163 patients with complete data sets were analysed: 77 with CKD and 86 with DM-CKD...
January 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29299227/strategies-and-performances-of-functional-electrical-stimulation-cycling-using-the-berkelbike-with-spinal-cord-injury-in-a-competition-context-cybathlon
#9
Rik Berkelmans, Billy Woods
The functional electrical stimulation (FES) bicycle race was an event at the Cybathlon, held in Zurich October 2016. BerkelBike BV (The Netherlands) in collaboration with Imperial College London entered a spinal cord injury pilot who had tetraplegia to compete in this event. The BerkelBike Pro is a commercially available FES capable recumbent which is normally driven by the arm- and leg power. The arm cranking part was disabled. Now the tricycle must be driven using the pilots own lower limb muscles through stimulation in accordance with race rules...
December 5, 2017: European Journal of Translational Myology
https://www.readbyqxmd.com/read/29237894/j-b-s-haldane-s-passage-to-india-reconfiguring-science
#10
Gordon Mcouat
In 1957, John Burdon Sanderson (JBS) Haldane (1892-1964), the world's leading population geneticist, committed political radical and one of the three 'founders' of neo-Darwinian 'Modern Synthesis' of twentieth century biology (Sarkar 1995; Haldane 1932; Cain 2009; Smocovitis 1996), ostentatiously renounced both his British citizenship and his prestigious chair at University College London. In a decisively and very public anti-imperial gesture, ostensibly played out as a reaction to the Suez crisis (although his discontent was simmering for quite some time), Haldane, and his partner, geneticistHelen Spurway (1917-1977), turned their backs on Britain and set off to India to offer their considerable scientific prestige, their inexhaustible organisational abilities, along with their leading Journal of Genetics, behind the efforts to build a 'modern', democratic India emerging out of the ashes of colonial rule...
November 2017: Journal of Genetics
https://www.readbyqxmd.com/read/29206944/the-direct-and-indirect-effects-of-kisspeptin-54-on-granulosa-lutein-cell-function
#11
L A Owens, A Abbara, A Lerner, S O'floinn, G Christopoulos, S Khanjani, R Islam, K Hardy, A C Hanyaloglu, S A Lavery, W S Dhillo, S Franks
STUDY QUESTION: What are the in vivo and in vitro actions of kisspeptin-54 on the expression of genes involved in ovarian reproductive function, steroidogenesis and ovarian hyperstimulation syndrome (OHSS) in granulosa lutein (GL) cells when compared with traditional triggers of oocyte maturation? SUMMARY ANSWER: The use of kisspeptin-54 as an oocyte maturation trigger augmented expression of genes involved in ovarian steroidogenesis in human GL cells including, FSH receptor (FSHR), LH/hCG receptor (LHCGR), steroid acute regulatory protein (STAR), aromatase, estrogen receptors alpha and beta (ESR1, ESR2), 3-beta-hydroxysteroid dehydrogenase type 2 (3BHSD2) and inhibin A (INHBA), when compared to traditional maturation triggers, but did not alter markers of OHSS...
February 1, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29103656/percutaneous-coronary-intervention-in-stable-angina-orbita-a-double-blind-randomised-controlled-trial
#12
RANDOMIZED CONTROLLED TRIAL
Rasha Al-Lamee, David Thompson, Hakim-Moulay Dehbi, Sayan Sen, Kare Tang, John Davies, Thomas Keeble, Michael Mielewczik, Raffi Kaprielian, Iqbal S Malik, Sukhjinder S Nijjer, Ricardo Petraco, Christopher Cook, Yousif Ahmad, James Howard, Christopher Baker, Andrew Sharp, Robert Gerber, Suneel Talwar, Ravi Assomull, Jamil Mayet, Roland Wensel, David Collier, Matthew Shun-Shin, Simon A Thom, Justin E Davies, Darrel P Francis
BACKGROUND: Symptomatic relief is the primary goal of percutaneous coronary intervention (PCI) in stable angina and is commonly observed clinically. However, there is no evidence from blinded, placebo-controlled randomised trials to show its efficacy. METHODS: ORBITA is a blinded, multicentre randomised trial of PCI versus a placebo procedure for angina relief that was done at five study sites in the UK. We enrolled patients with severe (≥70%) single-vessel stenoses...
January 6, 2018: Lancet
https://www.readbyqxmd.com/read/29071491/correction-to-iris-study-a-phase-ii-study-of-the-steroid-sulfatase-inhibitor-irosustat-when-added-to-an-aromatase-inhibitor-in-er-positive-breast-cancer-patients
#13
Carlo Palmieri, Rob C Stein, Xinxue Liu, Emma Hudson, Hanna Nicholas, Hironobu Sasano, Fouzia Guestini, Chris Holcombe, Sophie Barrett, Laura Kenny, Sadie Reed, Adrian Lim, Larry Hayward, Sacha Howell, R Charles Coombes
In the original publication of the article, a part of acknowledgement section was missed out. The omitted acknowledgement is given below: 'The study was coordinated by the Imperial Clinical Trials Unit-Cancer, Imperial College London and Sponsored by Imperial College London. The Imperial Clinical Trials Unit receives funding from the National Institute for Health (NIHR) Biomedical Research Centre based at Imperial College Healthcare NHS Trust and Imperial College London. The views expressed are those of the author(s) and not necessarily those of the NHS, the NIHR or the Department of Health...
January 2018: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29048498/the-nhli-at-imperial-college-london
#14
Sian Harding, Dorian Haskard, Kim Fox
No abstract text is available yet for this article.
October 14, 2017: European Heart Journal
https://www.readbyqxmd.com/read/29042393/effects-of-polyethylene-glycol-2-l-alone-or-with-ascorbic-acid-compared-with-polyethylene-glycol-4-l-alone-for-bowel-preparation-before-colonoscopy-protocol-for-a-systematic-review-and-network-meta-analysis
#15
Xu Tian, Wei-Qing Chen, Jie-Li Huang, Lan-Ying He, Bang-Lun Liu, Xi Liu, Hang Zhou, Bing-Rong Liu
INTRODUCTION: Colonoscopy has been regarded as a standard method of detecting and removing gastrointestinal lesions early, while adequate bowel preparation is the prerequisite of determining the diagnostic accuracy and treatment safety of this process. Polyethylene glycol (PEG) based bowel preparation regimens remain the first recommendation, but the optimal option is still uncertain. The aim of this systematic review and network meta-analysis of randomised controlled trials (RCTs) is to determine the optimal PEG based bowel preparation regimen before colonoscopy...
October 16, 2017: BMJ Open
https://www.readbyqxmd.com/read/29019456/introduction-paving-the-old-new-way-from-qing-to-china
#16
Ori Sela
The funeral procession of Sheng Xuanhuai (, 1844-1916) - the renowned Qing scholar-official, financier, and "father of Chinese industrialism" - meandered through the streets of Shanghai on 18 November 1917. The funeral was a grand event, one that was purportedly documented in film, later to be distributed as the first "news short-film" () in China. The North China Herald reported on the event in some detail, at times in rather florid language, and suggested that "the cortege was splendid and impressive, bringing back the days of the Manchu emperors...
September 2017: Science in Context
https://www.readbyqxmd.com/read/29018153/prednisolone-has-the-same-cardiovascular-risk-profile-as-hydrocortisone-in-glucocorticoid-replacement
#17
David J F Smith, Hemanth Prabhudev, Sirazum Choudhury, Karim Meeran
INTRODUCTION: Patients who need glucocorticoid replacement in both primary and secondary adrenal insufficiency (AI) have the choice of either once-daily prednisolone or thrice-daily hydrocortisone. A recent European study found no difference between prednisolone and hydrocortisone users in several markers including glucose, weight, body mass index, systolic and diastolic blood pressure and waist circumference, although an increase in cholesterol and low-density lipoprotein (LDL) was suggested in a subgroup of these patients...
November 2017: Endocrine Connections
https://www.readbyqxmd.com/read/28962567/holistic-feedback-approach-with-video-and-peer-discussion-under-teacher-supervision
#18
Agra Dilshani Hunukumbure, Susan F Smith, Saroj Das
BACKGROUND: High quality feedback is vital to learning in medical education but many students and teachers have expressed dissatisfaction on current feedback practices. Lack of teachers' insight into students' feedback requirements may be a key, which might be addressed by giving control to the students with student led feedback practices. The conceptual framework was built on three dimensions of learning theory by Illeris and Vygotsky's zone of proximal development and scaffolding. We introduced a feedback session with self-reflection and peer feedback in the form of open discussion on video-recorded student performances under teacher's guidance...
September 29, 2017: BMC Medical Education
https://www.readbyqxmd.com/read/28962548/validation-of-the-imperial-college-surgical-assessment-device-for-spinal-anesthesia
#19
Marcia A Corvetto, Carlos Fuentes, Andrea Araneda, Pablo Achurra, Pablo Miranda, Paola Viviani, Fernando R Altermatt
BACKGROUND: Traditionally, technical proficiency for spinal anesthesia has been assessed using observational scales such as global rating scales or task specific checklists. However more objective metrics are required in order to improve novice's training programs. The aim of this study is to validate the hand motion analysis of the Imperial College Surgical Assessment Device (ICSAD) in a simulated model of spinal anesthesia. METHODS: Three groups of physicians with different levels of experience were video recorded performing a spinal anesthesia in a simulated lumbar puncture torso...
September 29, 2017: BMC Anesthesiology
https://www.readbyqxmd.com/read/28948193/imperial-college-near-infrared-spectroscopy-neuroimaging-analysis-framework
#20
Felipe Orihuela-Espina, Daniel R Leff, David R C James, Ara W Darzi, Guang-Zhong Yang
This paper describes the Imperial College near infrared spectroscopy neuroimaging analysis (ICNNA) software tool for functional near infrared spectroscopy neuroimaging data. ICNNA is a MATLAB-based object-oriented framework encompassing an application programming interface and a graphical user interface. ICNNA incorporates reconstruction based on the modified Beer-Lambert law and basic processing and data validation capabilities. Emphasis is placed on the full experiment rather than individual neuroimages as the central element of analysis...
January 2018: Neurophotonics
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