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papillary thyroid microcarcinoma

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https://www.readbyqxmd.com/read/28900207/reevaluating-the-prognostic-significance-of-male-gender-for-papillary-thyroid-carcinoma-and-microcarcinoma-a-seer-database-analysis
#1
Chunping Liu, Tianwen Chen, Wen Zeng, Shuntao Wang, Yiquan Xiong, Zeming Liu, Tao Huang
The prognostic significance of gender remains controversial for papillary thyroid carcinoma (PTC). In this study, we investigated the associations between gender and prognosis in a large cohort of patients with PTC or PTMC that was diagnosed in 2010-2013 and recorded in the Surveillance, Epidemiology, and End Results cancer registry. The mean ± standard deviation duration of survival for all patients with PTC during the study period was 21.47 ± 14.04 months. In Kaplan-Meier analyses of the entire cohort of PTC patients, survival curves for all-cause death and cancer-specific death declined more sharply for men than for women...
September 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28884301/clinical-and-pathologic-predictors-of-central-lymph-node-metastasis-in-papillary-thyroid-microcarcinoma-a-retrospective-cohort-study
#2
C Y Gui, S L Qiu, Z H Peng, M Wang
OBJECTIVE: To identify the clinical and pathological predictors of central lymph node metastasis (CLNM) in patients with clinically lymph node-negative papillary thyroid microcarcinoma (PTMC). MATERIALS AND METHODS: Data pertaining to 541 clinically lymph node-negative PTMC patients who underwent thyroid surgery at the Shanghai General Hospital between January 2010 and December 2013 were retrospectively analyzed. According to histopathological evidence of central lymph node involvement, patients were divided into central lymph node metastasis (CLNM)-positive and CLNM-negative groups; risk factors for CLNM were identified statistically...
September 7, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/28859207/hashimoto-s-thyroiditis-is-an-important-risk-factor-of-papillary-thyroid-microcarcinoma-in-younger-adults
#3
Yujuan Liu, Chengqian Li, Wenjuan Zhao, Yangang Wang
The association between autoimmune thyroid disease and thyroid cancer remains unclear. We performed a matched case-control study to assess the association between Hashimoto's thyroiditis and papillary thyroid microcarcinoma (PTMC). A total of 927 PTMC cases and 927 age- and gender- matched controls selected from the same population were recruited. Odds ratio (OR) with 95% confidence interval (95% CI) was used to assess the strength of the association between Hashimoto's thyroiditis and PTMC. Conditional logistic regression analysis was carried out, and stratified analyses by age, gender and types of thyroid antibodies were also performed...
August 31, 2017: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/28858848/neutrophil-lymphocyte-ratio-nlr-and-platelet-lymphocyte-ratio-plr-may-be-superior-to-c-reactive-protein-crp-for-predicting-the-occurrence-of-differentiated-thyroid-cancer
#4
S Ozmen, O Timur, I Calik, K Altinkaynak, E Simsek, H Gozcu, A Arslan, A Carlioglu
OBJECTIVES: NLR (neutrophil-lymphocyte ratio) and PLR (platelet-lymphocyte ratio) are prognostic markers of differentiated thyroid cancers. In our study, we evaluated NLR, PLR and C-reactive protein (CRP) for predicting the occurence of differentiated thyroid cancer. This is the first study that compares NLR and PLR to C-reactive protein indifferantiated thyroid cancer not only papillary cancer but also folliculer cancer. METHODS: This study includes 51 papillary carcinoma, 42 papillary microcarcinoma and 31 folliculer carcinoma patients attending to our outpatient Endocrinology Clinic at Erzurum Region Training and Research Hospital between 2009 and 2014...
July 1, 2017: Endocrine Regulations
https://www.readbyqxmd.com/read/28835882/transoral-endoscopic-thyroidectomy-for-papillary-thyroid-microcarcinoma-initial-experience-of-a-single-surgeon
#5
Young Jun Chai, Jung Kee Chung, Angkoon Anuwong, Gianlorenzo Dionigi, Hoon Yub Kim, Ki-Tae Hwang, Seung Chul Heo, Ka Hee Yi, Kyu Eun Lee
PURPOSE: Recently, transoral endoscopic thyroidectomy (TOET) is receiving attention because it is regarded as a true minimally invasive surgery in that it does not leave scars on any part of the body and the area of flap dissection is similar to that of open surgery. In this study, we present the surgical procedures and initial outcomes of TOET in the treatment of papillary thyroid microcarcinoma (PTMC) patients. METHODS: The medical records of patients who underwent TOET for PTMC between July 2016 and February 2017 were retrospectively reviewed...
August 2017: Annals of Surgical Treatment and Research
https://www.readbyqxmd.com/read/28816539/non-operative-management-of-differentiated-thyroid-cancer-in-california-a-population-level-analysis-of-29-978-patients
#6
Eric J Kuo, James X Wu, Ning Li, Kyle A Zanocco, Michael W Yeh, Masha J Livhits
OBJECTIVE: There has been increasing interest in active surveillance of papillary thyroid microcarcinoma (mPTC). The objective of this study was to characterize the incidence and outcomes of non-operatively managed differentiated thyroid cancers (DTCs) in California. METHODS: Biopsy-proven DTCs from the California Cancer Registry (CCR) were linked to data from the California Office of Statewide Health Planning and Development (2004-2012). Low-risk tumors were defined as localized disease measuring < 4 cm without extrathyroidal extension, nodal involvement, or distant metastasis...
August 17, 2017: Endocrine Practice
https://www.readbyqxmd.com/read/28794343/comparative-histopathological-analysis-of-sporadic-pediatric-papillary-thyroid-carcinoma-from-japan-and-ukraine
#7
Tetiana I Bogdanova, Vladimir A Saenko, Mitsuyoshi Hirokawa, Masahiro Ito, Liudmyla Yu Zurnadzhy, Toshitetsu Hayashi, Tatiana I Rogounovitch, Akira Miyauchi, Mykola D Tronko, Shunichi Yamashita
This study set out to compare structural and invasive characteristics of sporadic papillary thyroid carcinoma (PTC) in age-matched groups of children and adolescents of Japan and Ukraine to provide detailed histopathological analysis of tumors from different geographical areas with different iodine intake. A total of 348 (160 Japanese and 188 Ukrainian) PTCs from patients without radiation history were analyzed initially as a combined pediatric group and then subdivided into childhood (aged ≤14 years) and adolescent (aged from 15 to ≤18 years) age series...
August 10, 2017: Endocrine Journal
https://www.readbyqxmd.com/read/28791920/detection-of-malignancy-among-suspicious-thyroid-nodules-less-than-1-cm-on-ultrasound-with-various-thyroid-image-reporting-and-data-systems
#8
Su Min Ha, Jung Hwan Baek, Jae Kyun Kim
<b>Background:</b> In patients undergoing active surveillance of papillary thyroid microcarcinoma (PTMC), definitive therapy-usually preceded by a definitive diagnostic procedure-is not recommended until evidence of disease progression is obtained, as stated in the American Thyroid Association (ATA) guidelines. This is because the deferring of definitive diagnosis and therapy until disease progression has no impact on the disease-specific survival. Here, we evaluated the malignancy rate and probability of thyroid nodules, which was further stratified based on the size cut-off value of 1 cm, with suspicious findings on ultrasonography (US), by using various malignant stratification systems...
August 9, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28760234/thyroid-cancer-ultrasound-imaging-and-fine-needle-aspiration-biopsy
#9
REVIEW
Michelle Melany, Sardius Chen
Ultrasound is critical in detection, diagnosis, and management of thyroid nodules. Ultrasound detection of regional nodal metastatic disease is based on abnormal nodal morphology rather than size and is critical to initial surgical and long-term management of thyroid cancer. Fine-needle aspiration biopsy is the gold standard for malignancy diagnosis in thyroid cancer. Thyroglobulin assay of nodal aspirates improves accuracy in diagnosis of metastases. Reporting lexicons assign risk levels to thyroid nodules with the goal of improving and standardizing patient management...
September 2017: Endocrinology and Metabolism Clinics of North America
https://www.readbyqxmd.com/read/28744725/impact-of-major-different-variants-of-papillary-thyroid-microcarcinoma-on-the-clinicopathological-characteristics-the-study-of-1041-cases
#10
Jingtai Zhi, Jingzhu Zhao, Ming Gao, Yi Pan, Jianghua Wu, Yigong Li, Dapeng Li, Yang Yu, Xiangqian Zheng
BACKGROUND: The incidence of papillary thyroid microcarcinoma (PTMC) has been increasing globally in the past few decades. PTMC does not have a distinctive morphology that results in differences in biological behavior. The aim of this study was to classify PTMCs according to the morphological features and explore the relationship with clinicopathological characteristics. Additionally, we sought to evaluate whether different variants of PTMC can be an independent predictor for lymph mode metastasis when considering other risk factors...
July 25, 2017: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28741452/young-age-and-male-sex-are-predictors-of-large-volume-central-neck-lymph-node-metastasis-in-clinical-n0-papillary-thyroid-microcarcinomas
#11
Hye-Seon Oh, Suyeon Park, Mijin Kim, Hyemi Kwon, Eyun Song, Tae-Yon Sung, Yu-Mi Lee, Won Gu Kim, Tae Yong Kim, Young Kee Shong, Won Bae Kim, Min Ji Jeon
BACKGROUND: Large-volume lymph node metastasis (LNM) is associated with poor clinical outcomes in papillary thyroid microcarcinoma (PTMC) patients. However, sensitivity in the detection of central neck LNM on preoperative neck ultrasonography (US) is believed to be low. The aim of this study is to investigate the preoperative clinical factors associated with large-volume LNM in clinical N0 PTMC patients. METHODS: In all, 2329 clinical N0 PTMC patients who underwent total thyroidectomy with prophylactic central lymph node (LN) dissection were evaluated...
August 17, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28741199/radioactive-iodine-ablation-decrease-recurrences-in-papillary-thyroid-microcarcinoma-with-lateral-lymph-node-metastasis-in-chinese-patients
#12
Shuai Xue, Peisong Wang, Jia Liu, Guang Chen
INTRODUCTION: We aimed to carry out a retrospective study from a single institution to determine whether radioactive iodine (RAI) ablation decreases the risk of recurrence of papillary thyroid microcarcinoma (PTMC) patients that presented with lateral lymph node metastasis (LLNM). METHODS: We retrospectively analyzed a total of 6361 consecutive PTMC patients who initially underwent surgery for the treatment of thyroid carcinoma at the First Hospital of Jilin University, between January 2005 and February 2015...
July 24, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28717869/transoral-endoscopic-thyroidectomy-vestibular-approach-toetva-indications-techniques-and-results
#13
Angkoon Anuwong, Thanyawat Sasanakietkul, Pornpeera Jitpratoom, Khwannara Ketwong, Hoon Yub Kim, Gianlorenzo Dionigi, Jeremy D Richmon
INTRODUCTION: The Transoral Neck Surgery (TONS) Study Group was established at the 1st International Thyroid NOTES Conference in February 2016 with the intention of standardizing and refining thyroid NOTES techniques, including both transoral endoscopic and robotic thyroidectomy approaches. Herein, the authors report the modification of indications, preparation, and step-by-step explanations for operative techniques, as well as results and postoperative care for transoral endoscopic thyroidectomy vestibular approach (TOETVA)...
July 17, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28716127/influence-of-tumor-extent-on-central-lymph-node-metastasis-in-solitary-papillary-thyroid-microcarcinomas-a-retrospective-study-of-1092-patients
#14
Xingjie Yin, Chunping Liu, Yawen Guo, Xiaoyu Li, Na Shen, Xiangwang Zhao, Pan Yu, Shan Wang, Zeming Liu
BACKGROUND: The morbidity of papillary thyroid microcarcinomas is increasing worldwide. Surgery is the main treatment for papillary thyroid microcarcinomas, and the choice of surgical method partly depends on the T stage of the tumor. However, according to the American Joint Commission on Cancer staging system (7th edition), the T stage of papillary thyroid microcarcinomas with different tumor extent is unclear. We aimed to study the effect of tumor extent and other factors on central lymph node metastasis to explore the relationship between tumor extent and T stage and to identify the risk factors predicting central lymph node metastasis in papillary thyroid microcarcinomas...
July 17, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28713699/transoral-thyroidectomy-why-is-it-needed
#15
REVIEW
Gianlorenzo Dionigi, Matteo Lavazza, Chei-Wei Wu, Hui Sun, Xiaoli Liu, Ralph P Tufano, Hoon Yub Kim, Jeremy D Richmon, Angkoon Anuwong
Transoral thyroidectomy (TOT) represents reasonably the desirable minimally invasive approach to the gland due to the scarless non-visible incisions, the limited distance between the gland and the access that minimize tissue dissection and respect of the surgical anatomical planes. Patients are routinely selected according to an extensive inclusion criteria: (I) ultrasonographically (US) estimated thyroid diameter not larger than 10 cm; (II) US gland volume ≤45 mL; (III) nodule size ≤50 mm; (IV) a benign tumor, such as a thyroid cyst, single-nodular goiter, or multinodular goiter; (V) follicular neoplasm; (VI) papillary microcarcinoma without lymph node metastasis...
June 2017: Gland Surgery
https://www.readbyqxmd.com/read/28710706/synchronous-and-metastatic-papillary-and-follicular-thyroid-carcinomas-with-unique-molecular-signatures
#16
Vincent Cracolici, Ibro Mujacic, Sabah Kadri, Mir Alikhan, Nifang Niu, Jeremy P Segal, Lauren E Rosen, David H Sarne, Adam Morgan, Samy Desouky, Nicole A Cipriani
Despite the relatively high prevalence of thyroid cancer, the occurrence of multiple synchronous, distinct subtypes of primary thyroid carcinoma is uncommon. The incidental finding of papillary thyroid microcarcinoma in a gland with a biologically relevant follicular or medullary carcinoma is more frequent than the synchronous occurrence of multiple clinically significant carcinomas. We report a case of synchronous papillary and follicular thyroid carcinomas metastatic to lymph node and bone, respectively. Next generation sequencing showed BRAF V600E mutation in the primary papillary carcinoma and NRAS Q61R mutation in the primary follicular carcinoma and bony metastasis...
July 14, 2017: Endocrine Pathology
https://www.readbyqxmd.com/read/28703115/incidental-diagnosis-of-the-tall-cell-variant-of-the-papillary-microcarcinoma-of-the-thyroid-gland-requires-completion-lymphadenectomy-case-report
#17
I Bartella, F Meyer, K Frauenschläger, K Reschke, Th Wallbaum, B Buth, C Bruns, C Chiapponi
Papillary thyroid carcinoma is the most common neoplasm of the thyroid gland which is usually associated with a very good prognosis. The aim of this case report is to present the disease course of a rare tumor of the thyroid gland, which is worthwhile due to its extraordinary appearance and specific management. A 46-year-old patient presented with a pronounced right-sided, but bilateral, multinodular goiter, with a volume of approximately 80 mL, as assessed on ultrasonography. Surgical removal was indicated as scintigraphy showed a 4-cm cold nodule that almost completely took up the right thyroid lobe...
June 30, 2017: Polski Przeglad Chirurgiczny
https://www.readbyqxmd.com/read/28680105/braf-and-nras-mutations-in-papillary-thyroid-carcinoma-and-concordance-in-braf-mutations-between-primary-and-corresponding-lymph-node-metastases
#18
Najla Fakhruddin, Mark Jabbour, Michael Novy, Hani Tamim, Hisham Bahmad, Fadi Farhat, Ghazi Zaatari, Tarek Aridi, Gernot Kriegshauser, Christian Oberkanins, Rami Mahfouz
Concordance between mutations in the primary papillary thyroid carcinoma (PTC) and the paired x lymph node metastasis may elucidate the potential role of molecular targeted therapy in advanced stages. BRAF and NRAS mutations in primary PTC (n = 253) with corresponding metastatic lymph node (n = 46) were analyzed utilizing StripAssays (ViennaLab Diagnostics). Statistical analysis was performed using (SPSS, Inc.), version 24.0 with a p-value of <0.05, and concordance via kappa agreement. BRAF mutation frequency in conventional PTC (cPTC): 56...
July 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28661604/-is-it-necessary-to-perform-a-central-lymphodissection-in-highly-differentiated-iviicrocarcinoiva-of-thyroid-gland
#19
S N Zavgorodniy, M B Danilyuk, A I Rylov, O S Dolya
The rate of the highly differentiated thyroid microcarcinoma methastasizing in central (6th) group of cervical lymph nodes was studied. In the clinic in 2013 - 2015 yrs 62 patients were operated for primary thyroid microcarcinoma. In accordance to TNM (UICC, AJCC, 2009) classification, papillary cancer in stage TlaNOMO was diagnosed in 35 (56.5%) patients, T1aN1MO - in 22 (35.5%); follicular cancer stage T1aNOMO - in 2 (3.2%); papillary cancer, follicular variant in stage T1aN1 MO - in 2 (3.2%); follicu- lar cancer, papillary variant in stage T1aNOMO - in 1 (1...
August 2016: Klinichna Khirurhiia
https://www.readbyqxmd.com/read/28659720/the-genetics-of-papillary-microcarcinomas-of-the-thyroid-diagnostic-and-prognostic-implications
#20
REVIEW
Ana Cunha Rodrigues, Gustavo Penna, Elisabete Rodrigues, Patrícia Castro, Manuel Sobrinho-Simões, Paula Soares
Papillary microcarcinoma of the thyroid (mPTC) is defined by the WHO as a papillary thy-roid cancer measuring 10mm or less in diameter and it is nowadays a topic of intense debate among the members of the medical community due to its apparent "epidemic" rise. Although these tumors follow almost always an indolent clinical course and carry an excellent prognosis, it is known that a small sub-set may display a potentially aggressive behavior. Nevertheless, we still lack an accurate way of predict-ing those which will cause significant disease...
June 2017: Current Genomics
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