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papillary thyroid microcarcinoma

Xuemei Gao, Xiao Zhang, Yajing Zhang, Wenjuan Hua, Yusufu Maimaiti, Zairong Gao
The increasing detection of papillary thyroid microcarcinoma (PTMC) has created management dilemmas. To clarify the clinical significance of postsurgery stimulated thyroglobulin (ps-Tg) in PTMC who undergo thyroidectomy and radioactive iodine (RAI), we retrospectively reviewed the 358 PTMC patients who were treated with RAI and followed up in our hospital. Those with an excessive anti-Tg antibody, ultrasound-detected residual were excluded, thereby resulting in the inclusion of 280 cases. Their clinical and histopathological information and clinical outcomes were collected and summarized...
October 2016: Medicine (Baltimore)
Marianna Grigerová, Martin Griger, Emília Mojtová, Ján Podoba
Low risk differentiated thyroid microcarcinoma therapy is a controversial area of thyroid tumor management. Major international medical societies and reputable institutes consider lobectomy to be sufficient therapeutic intervention for the pT1a cN0cM0 stage of papillary thyroid microcarcinoma. However different views and therapeutic strategies exist and result in unnecessary overtreatment and worsening of patients quality of life. We researched the course of the differentiated thyroid microcarcinoma in patients using different therapeutic strategies: lobectomy, total thyroidectomy, total thyroidectomy with central compartment prophylactic lymphadenectomy and total thyroidectomy followed by radioactive iodine treatment...
2016: Vnitr̆ní Lékar̆ství
Ibtissem Oueslati, Karima Khiari, Emna Elfeleh, Néjib Ben Abdallah
No abstract text is available yet for this article.
September 2016: Indian Journal of Endocrinology and Metabolism
Ka Hee Yi
Increased detection of thyroid nodules using high-resolution ultrasonography has resulted in a world-wide increase in the incidence of differentiated thyroid cancer (DTC). Despite the steep increase in its incidence, the age-standardized mortality rate of thyroid cancer has remained stable, which leads toward a trend of more conservative treatment. The latest American Thyroid Association (ATA) guidelines for thyroid nodules and thyroid cancer revised in 2015 suggested that fine needle aspiration biopsy should be performed for thyroid nodules larger than 1 cm and lobectomy might be sufficient for 1 to 4 cm intrathyroidal DTC...
September 2016: Endocrinology and Metabolism
Lester D R Thompson, Hannah B Herrera, Sean K Lau
Carcinomas arising from thyroglossal duct remnant cysts (TGDCs) are rare, without well-defined management and staging criteria. All TGDCs (n = 685) diagnosed between 2005 and 2015 were retrospectively reviewed, with 22 carcinomas identified (3.2 % incidence). Twenty-two patients (17 females, 5 males), aged 12-64 years (mean 39.9 years; median 39 years) were identified. An anterior, superior midline neck mass was the presenting symptom in all patients. A cancer diagnosis [all papillary thyroid carcinoma (PTC)] was made after the Sistrunk procedure (SP), with a Bethesda Category V or VI classification preoperatively by fine needle aspiration in 5 of 12 cases tested...
October 4, 2016: Head and Neck Pathology
Bo Li, Yaqiong Zhang, Ping Yin, Jian Zhou, Tian'an Jiang
The present study aimed to investigate the value of ultrasonography in the diagnosis of papillary thyroid microcarcinoma (PTMC) coexisting with a thyroid abnormality, and to improve the accuracy of PTMC diagnosis. The ultrasonic features of 38 PTMC nodules coexisting with a thyroid abnormality and 56 thyroid benign nodules, obtained by surgical resection and confirmed by pathological analysis, were retrospectively analyzed. All masses were ≤ 1.0 cm in diameter. Ultrasonic features that were analyzed included the shape, aspect ratio, boundary, margin, echo, uniformity, presence or absence of microcalcification and enlargement of the lymph nodes, as well as the blood flow of the nodules...
October 2016: Oncology Letters
C R McHenry, H Shi
No abstract text is available yet for this article.
September 30, 2016: World Journal of Surgery
Seok Woo Yang, Seong-Ho Kang, Kyung Rae Kim, In Hong Choi, Hang Seok Chang, Young Lyun Oh, Soon Won Hong
BACKGROUND: Papillary thyroid carcinoma (PTC) is frequently accompanied by lymphocytic thyroiditis (LT). Some reports claim that Hashimoto's thyroiditis (the clinical form of LT) enhances the likelihood of PTC; however, others suggest that LT has antitumor activity. This study was aimed to find out the relationship between the patterns of helper T cell (Th) cytokines in thyroid tissue of PTC with or without LT and the clinicopathological manifestation of PTC. METHODS: Fresh surgical samples of PTC with (13 cases) or without (10 cases) LT were used...
September 2016: Journal of Pathology and Translational Medicine
Hitomi Oda, Akira Miyauchi, Yasuhiro Ito, Hisanori Sasai, Hiroo Masuoka, Tomonori Yabuta, Mitsuhiro Fukushima, Takuya Higashiyama, Minoru Kihara, Kaoru Kobayashi, Akihiro Miya
The incidence of thyroid cancer is increasing rapidly in many countries, resulting in rising societal costs of the care of thyroid cancer. We reported that the active surveillance of low-risk papillary microcarcinoma had less unfavorable events than immediate surgery, while the oncological outcomes of these managements were similarly excellent. Here we calculated the medical costs of these two managements. We created a model of the flow of these managements, based on our previous study. The flow and costs include the step of diagnosis, surgery, prescription of medicine, recurrence, salvage surgery for recurrence, and care for 10 years after the diagnosis...
September 22, 2016: Endocrine Journal
Liang-Sen Liu, Jia Liang, Jun-Hong Li, Xue Liu, Li Jiang, Jian-Xiong Long, Yue-Ming Jiang, Zhi-Xiao Wei
Although there have been many studies identifying clinical and pathologic factors that may predict central lymph node metastases (CLNM) in papillary thyroid microcarcinoma (PTMC) patients without clinically cervical lymph node metastasis (cN0), the results were inconsistent. And whether prophylactic central lymph node dissection (pCLND) should be performed in cN0 PTMC remains controversial. The EMBASE, PubMed, MEDLINE and the Cochrane Library were searched until Oct 2015 to identify relevant studies. Primary outcomes were clinical and pathologic factors for CLNM...
September 19, 2016: European Archives of Oto-rhino-laryngology
Miaoyun Long, Dingyuan Luo, Feiyu Diao, Mingqing Huang, Kai Huang, Xinzhi Peng, Shaojian Lin, Honghao Li
The study assessed the role of an activated carbon nanoparticle lymphatic tracer in reducing unintentional damage to the parathyroid glands during thyroidectomy for papillary thyroid non-microcarcinoma diagnosed intraoperatively by cryosections. A total of 103 patients with papillary thyroid non-microcarcinomas diagnosed by intraoperative cryosection were randomly assigned to receive routine radical thyroidectomy or radical thyroidectomy following administration of activated carbon nanoparticle lymphatic tracer to the contralateral thyroid, at the department of Thyroid Surgery, Sun Yat-sen Memorial Hospital (Guangzhou, China), between January 2012 and May 2013...
September 15, 2016: Surgical Innovation
Krzysztof Kaliszewski, Agnieszka Zubkiewicz-Kucharska, Beata Wojtczak, Marta Strutyńska-Karpińska
BACKGROUND: Thyroid microcarcinoma (TMC) often occurs as two or more separate foci, therefore a completion of primary surgery might be necessary. OBJECTIVES: To evaluate and compare the incidence, diagnostic accuracy, clinicopathological characteristics and surgical treatment of unifocal and multifocal thyroid microcarcinoma (UTMC vs. MTMC). MATERIAL AND METHODS: We retrospectively analyzed 3,218 medical records of patients consecutively admitted and surgically treated in one center due to thyroid pathology...
May 2016: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
Qing-Qing He, Jian Zhu, Da-Yong Zhuang, Zi-Yi Fan, Lu-Ming Zheng, Peng Zhou, Lei Hou, Fang Yu, Yan-Ning Li, Lei Xiao, Xue-Feng Dong, Gao-Feng Ni
BACKGROUND: A large proportion of the patients with papillary thyroid microcarcinoma are young women. Therefore, minimally invasive endoscopic thyroidectomy with central neck dissection (CND) emerged and showed well-accepted results with improved cosmetic outcome, accelerated healing, and comforting the patients. This study aimed to evaluate the safety and effectiveness of robotic total thyroidectomy with CND via bilateral axillo-breast approach (BABA), compared with conventional open procedure in papillary thyroid microcarcinoma...
2016: Chinese Medical Journal
Dao-Zhe Lin, Ning Qu, Rong-Liang Shi, Zhong-Wu Lu, Qing-Hai Ji, Wei-Li Wu
The surgical management of papillary thyroid microcarcinoma (PTMC), especially regarding the necessity of central/lateral lymph node dissection, remains controversial. This study investigated the clinicopathologic factors predictive of lymph node metastasis (LNM) in patients diagnosed with PTMC. Multivariate logistic regression analysis was used for PTMC patients identified from the Surveillance, Epidemiology, and End Results database who were treated by surgery between 2002 and 2012, to determine the association of clinicopathologic factors with LNM...
2016: OncoTargets and Therapy
Seo Ki Kim, Inhye Park, Jung-Woo Woo, Jun Ho Lee, Jun-Ho Choe, Jung-Han Kim, Jee Soo Kim
BACKGROUND: Because there is a controversy regarding the management of papillary thyroid microcarcinoma, the purpose of this study was to compare lobectomy with total thyroidectomy as a primary operative treatment for papillary thyroid microcarcinoma. Loco-regional recurrence in the contralateral remnant lobe can be managed safely by completion thyroidectomy via the previous scar. However, reoperation for operation bed (thyroidectomy site) or regional lymph node (central or lateral) recurrence generally is associated with morbidity...
September 1, 2016: Surgery
Nassim Essabah Haraj, Hayat Ahandar, Siham El Aziz, Asma Chadli
The presence of hyperthyroidism is no longer an insurance against the occurrence of thyroid cancer. The combination of the two is common. This is a retrospective study of 355 files of patients followed for differentiated thyroid cancer in the endocrinology department at CHU IBN ROCHD from 1986 to 2014. 12 of those patients were followed for hyperthyroidism, and a fortuitous association with differentiated thyroid cancer was found during the anatomopathological exam, giving us a 3.38% prevalence. The average age of discovery is 44...
2016: Pan African Medical Journal
Liborio Torregrossa, David Viola, Elisa Sensi, Mirella Giordano, Paolo Piaggi, Cristina Romei, Gabriele Materazzi, Paolo Miccoli, Rossella Elisei, Fulvio Basolo
CONTEXT: Approximately 40% of papillary thyroid carcinomas (PTC) harbor the BRAF V600E mutation, which is significantly associated with the advanced clinico-pathological features of PTC at diagnosis, higher recurrence rate and disease-related mortality. BRAF alterations other than V600E are less common in PTC, and their clinical significance remains to be established. OBJECTIVE: The aim of the study was to describe a large cohort of rare exon 15 BRAF alterations (r-BRAF), the clinico-pathological features of PTC harboring these alterations and to clarify their clinical significance...
August 29, 2016: Journal of Clinical Endocrinology and Metabolism
Saul Levy-Blitchtein, Stefany Plasencia-Rebata, Domingo Morales Luna, Juana Del Valle Mendoza
Papillary thyroid cancer (PTC) represents 80-85% of thyroid cancer and its prevalence has been rising in the last decades. Primary thyroid lymphoma (PTL) accounts for 3% of extranodal lymphomas and about 5% of thyroid malignancies, having a prevalence of one or two cases per million people. Mucosa-Associated Lymphoid Tissue lymphoma represents approximately 30% of PTL. Both entities have an indolent course and a very good prognosis. Diagnosis is made by ultrasound and fine needle aspiration (FNA) or surgery specimen pathology...
August 2016: Asian Pacific Journal of Tropical Medicine
Sophie Leboulleux, R Michael Tuttle, Furio Pacini, Martin Schlumberger
The incidence of differentiated thyroid cancer is increasing greatly in high-income countries. Roughly 50% of this increase is attributable to the identification of intrathyroidal papillary thyroid microcarcinomas. Since mortality associated with these tumours remains low and stable, the increasing diagnosis has led to concerns about overdiagnosis and overtreatment. Management of papillary thyroid microcarcinomas should take into account the reported absence of mortality when diagnosed in the absence of lymph node metastases and distant metastases, as shown even in recent studies promoting active surveillance; a low recurrence rate of 1-5%; and the risk of permanent complications from surgery that cannot be decreased to less than 1-3%, even in high-volume tertiary care centres with experienced surgeons...
August 20, 2016: Lancet Diabetes & Endocrinology
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