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papillary thyroid microcarcinoma

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https://www.readbyqxmd.com/read/28224278/the-need-of-prophylactic-central-lymph-node-dissection-is-controversial-in-terms-of-postoperative-thyroglobulin-follow-up-of-patients-with-cn0-papillary-thyroid-cancer
#1
Mehmet Hakan Korkmaz, Bülent Öcal, Güleser Saylam, Erman Çakal, Ömer Bayır, Esra Tutal, Emel Çadallı Tatar
PURPOSE: The objective of this study was to investigate whether prophylactic central lymph node dissection (pCLND) facilitates postoperative thyroglobulin (Tg) follow-up in the patients with papillary thyroid carcinoma (PTC). We also questioned whether radioactive iodine (RAI) remnant ablation provides any further advantage in this regard. METHODS: The records of patients with low-intermediate risk PTC who underwent either only total thyroidectomy (TT) or TT in conjunction with pCLND were reviewed...
February 21, 2017: Langenbeck's Archives of Surgery
https://www.readbyqxmd.com/read/28217964/is-fine-needle-aspiration-really-not-necessary-in-patients-with-thyroid-nodules%C3%A2-%C3%A2-%C3%A2-1-cm-with-highly-suspicious-features-on-ultrasonography-and-candidates-for-active-surveillance
#2
Pedro Weslley Rosario, Alexandre Lemos Silva, Maria Regina Calsolari
BACKGROUND: The low rate of progression associated with the potential complications of thyroidectomy makes active surveillance an increasingly recommended management in low-risk papillary microcarcinomas of the thyroid (PMT). The objective of this study was to report the results of fine needle aspiration (FNA) of nodules ≤ 1 cm with highly suspicious appearance on ultrasonography (US) in patients who are potential candidates for active surveillance. METHODS: We revised thyroid nodules ≤ 1 cm with highly suspicious appearance on US in patients without known distant metastases, suspicion of extrathyroid extension, or suspicious lymph nodes on US...
February 20, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28209140/papillary-thyroid-microcarcinoma-the-significance-of-high-risk-features
#3
Nori L Bradley, Sam M Wiseman
BACKGROUND: Papillary carcinomas that measure 1.0cm or less are diagnosed as papillary thyroid microcarcinomas (PTMs). The clinical significance and recommendations for management of these PTMs is still evolving. The objective of the study was to compare the characteristics of small (<5mm) to large (≥ 5mm) papillary thyroid microcarcinomas. METHODS: Amongst 1459 sequential patients undergoing thyroid surgery at a single center, 132 (9%) cases were diagnosed with PTM...
February 16, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28202579/occupational-exposure-to-pesticides-and-other-biocides-and-risk-of-thyroid-cancer
#4
Fanhua Zeng, Catherine Lerro, Jérôme Lavoué, Huang Huang, Jack Siemiatycki, Nan Zhao, Shuangge Ma, Nicole C Deziel, Melissa C Friesen, Robert Udelsman, Yawei Zhang
OBJECTIVES: To assess the associations between occupational exposure to biocides and pesticides and risk of thyroid cancer. METHODS: Using data from a population-based case-control study involving 462 incident thyroid cancer cases and 498 controls in Connecticut collected in 2010-2011, we examined the association with occupational exposure to biocides and pesticides through a job-exposure matrix. We used unconditional logistic regression models to estimate OR and 95% CI, adjusting for potential confounders...
February 15, 2017: Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28194993/preoperative-prediction-of-papillary-thyroid-microcarcinoma-via-multiparameter-ultrasound
#5
Hui Juan Ma, Jing Chun Yang, Zhen Peng Leng, Ying Chang, Hua Kang, Liang Hong Teng
Background Accurate diagnosis of papillary thyroid microcarcinoma (PTMC) is important for further management. Ultrasound (US) is the most frequently used imaging modality for PTMC. Purpose To evaluate the diagnostic value of conventional US, contrast-enhanced ultrasound (CEUS) and real-time elastography (RTE) for patients with PTMC. Material and Methods In total, 135 patients with subcentimeter thyroid nodules who underwent conventional US, CEUS, and RTE before surgery were enrolled. A multivariate logistic regression analysis was performed to assess the independent predictors of PTMC...
January 1, 2017: Acta Radiologica
https://www.readbyqxmd.com/read/28182829/transoral-endoscopic-thyroidectomy-vestibular-approach-toetva-from-a-to-z
#6
Gianlorenzo Dionigi, Matteo Lavazza, Alessandro Bacuzzi, Davide Inversini, Vincenzo Pappalardo, Ralph P Tufano, Hoon Yub Kim, Angkoon Anuwong
We depict the transoral endoscopic thyroidectomy vestibular approach (TOETVA). Patient selection criteria are (1) ultrasonographically (US) estimated thyroid diameter no larger than 10cm, (2) US estimated gland volume ≥45mL, (3) nodule size ≥5mm, (4) a benign tumor, such as a thyroid cyst, single-nodular goiter, or multinodular goiter, (5) follicular neoplasm, and (6) papillary microcarcinoma without evidence of metastasis. TOETVA is carried out through a three-port technique placed at the oral vestibule, one 10mm port for 30° endoscope and two additional 5mm ports for dissecting and coagulating instruments...
February 7, 2017: Surgical Technology International
https://www.readbyqxmd.com/read/28165567/surgical-safety-analysis-of-retaining-the-glands-in-papillary-thyroid-microcarcinoma
#7
B Ding, J-F Yu, W Sun, N-F Ma
OBJECTIVE: The objective of the present study was to analyze the surgical safety of retaining the glands in papillary thyroid microcarcinoma (mPTC). PATIENTS AND METHODS: 156 cases of mPTC were retrospectively reviewed and divided into four groups according to the treatment: group A (conservative follow-up group, 30 cases), group B (total resection of unilateral gland combined with isthmic resection, 48 cases), group C (total resection of unilateral gland combined with subtotal resection of contralateral gland, 47 cases), and group D (total resection of bilateral glands, 31 cases)...
January 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28156153/should-multifocal-papillary-thyroid-carcinomas-classified-as-t1a-having-the-sum-of-tumor-diameters-1-2-centimeter-be-reclassified-as-t1b
#8
Abbas Ali Tam, Didem Ozdemir, Berna Evranos Ogmen, Sevgul Fakı, Ersin Gurkan Dumlu, Aylin Kılıc Yazgan, Reyhan Ersoy, Bekir Cakır
OBJECTIVE: Considering the diameter of the largest tumor while determining T stage in multifocal papillary thyroid microcarcinomas (PTMC) might cause underestimation of tumoral stage. We aimed to investigate the effect of total tumor diameter (TTD) on TNM classification in multifocal T1a PTMCs. METHODS: T1 tumors were grouped as T1a and T1b according to 7th TNM edition. For patients with multifocal T1a, TTD (the sum of the maximal diameter of each foci) was calculated and these patients were further subgrouped as TTD ≤1 cm and TTD 1-2 cm...
February 3, 2017: Endocrine Practice
https://www.readbyqxmd.com/read/28154351/natural-history-of-thyroid-cancer-review
#9
Toru Takano
Thyroid cancers have long been considered to arise in middle age and, after their repeated proliferation, resulting in further damage to the genome, they progress to more aggressive and lethal cancers. However, in 2014, some studies were reported that might lead to a marked change in our understanding of the natural history of thyroid cancer. A high prevalence of papillary carcinoma in the young suggested that the first initiation of thyroid cancer is likely to occur in the infantile period. Such a conclusion was also supported by a very slow growth rate of papillary microcarcinomas (PMCs) in an observation trial...
February 2, 2017: Endocrine Journal
https://www.readbyqxmd.com/read/28149809/transoral-endoscopic-thyroidectomy-via-vestibular-approach-operative-steps-and-video
#10
Gianlorenzo Dionigi, Alessandro Bacuzzi, Matteo Lavazza, Davide Inversini, Vincenzo Pappalardo, Luigi Boni, Stefano Rausei, Marcin Barczynski, Ralph P Tufano, Hoon Yub Kim, Angkoon Anuwong
In this video we describe transoral endoscopic thyroidectomy vestibular approach (TOETVA). Inclusion criteria are (I) patients who had a ultrasonographically (US) estimated thyroid diameter not larger than 10 cm; (II) US estimated gland volume ≤45 mL; (III) nodule size ≤50 mm; (IV) a benign tumor, such as a thyroid cyst, single-nodular goiter, or multinodular goiter; (V) follicular neoplasm; (VI) papillary microcarcinoma without evidence of metastasis. The procedure is carried out through three-port technique placed at the oral vestibule, one 10-mm port for 30° endoscope and two additional 5-mm ports for dissecting and coagulating instruments...
December 2016: Gland Surgery
https://www.readbyqxmd.com/read/28130621/is-male-gender-a-prognostic-factor-for-papillary-thyroid-microcarcinoma
#11
Yi Ho Lee, Yu Mi Lee, Tae Yon Sung, Jong Ho Yoon, Dong Eun Song, Tae Yong Kim, Jung Hwan Baek, Jin Suk Ryu, Ki Wook Chung, Suck Joon Hong
BACKGROUND: Male gender is a prognostic factor of poor outcome in papillary thyroid carcinoma (PTC). We investigated the prognostic role of male gender in papillary thyroid microcarcinoma (PTMC). METHODS: We included 2930 patients who underwent surgery at Asan Medical Center for PTC. Clinicopathologic characteristics from the patients' medical records were compared for male and female PTC patients. Independent prognostic factors for recurrence in PTC and PTMC were evaluated after propensity score matching analysis...
January 27, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28125992/diagnostic-accuracy-of-ultrasonographic-features-for-lymph-node-metastasis-in-papillary-thyroid-microcarcinoma-a-single-center-retrospective-study
#12
Zeming Liu, Wen Zeng, Chunping Liu, Shuntao Wang, Yiquan Xiong, Yawen Guo, Xiaoyu Li, Shiran Sun, Tianwen Chen, Yusufu Maimaiti, Pan Yu, Tao Huang
BACKGROUND: Whether sonography is an appropriate imaging modality for cervical lymph nodes in patients with papillary thyroid microcarcinoma (PTMC) remains unclear. Hence, this study aimed to evaluate the diagnostic value of ultrasonography (US) features for lymph node metastasis in PTMC. METHODS: Seven hundred twelve patients with PTMC who underwent conventional ultrasonography examinations of the cervical lymph nodes were included. All included cases underwent total thyroidectomy plus prophylactic central lymph node dissection...
January 26, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28124394/treatment-decision-making-in-early-stage-papillary-thyroid-cancer
#13
Thomas A D'Agostino, Elyse Shuk, Erin K Maloney, Rebecca Zeuren, R Michael Tuttle, Carma L Bylund
OBJECTIVE: The purpose of this study was to develop an in-depth understanding of papillary microcarcinoma (PMC) patients' decision-making process when offered options of surgery and active surveillance. METHODS: 15 PMC patients and six caregivers participated in either a focus group or individual interview. Focus groups were segmented by patients' treatment choice. Primary themes were identified in transcripts using thematic text analysis. RESULTS: Four themes emerged from the surgery subsample: (1) Decision to undergo thyroidectomy quickly and with a sense of urgency; (2) Perception of PMC as a potentially life-threatening disease; (3) Fear of disease progression and unremitting uncertainty with active surveillance; and (4) Surgery as a means of control and potential cure...
January 26, 2017: Psycho-oncology
https://www.readbyqxmd.com/read/28123728/clinicopathological-features-for-predicting-central-and-lateral-lymph-node-metastasis-in-papillary-thyroid-microcarcinoma-analysis-of-66-cases-that-underwent-central-and-lateral-lymph-node-dissection
#14
Yang Tao, Chongjie Wang, Liye Li, Haijun Xing, Yun Bai, Bing Han, Zhiyan Liu, Xiangshan Yang, Shourong Zhu
Currently the surgical approach for papillary thyroid microcarcinoma (PTMC), particularly the range of lymph node dissection, remains controversial. The present study aims to evaluate the risk factors for central and lateral lymph node metastasis (CLNM and LLNM) for appropriate clinical decision of neck lymph node dissection in PTMC. A total of 66 cases of PTMC that underwent unilateral or bilateral lobectomy plus prophylactic cervical lymph node dissection were collected for clinicopathological evaluation, including age, gender, tumor size, subtypes, extrathyroidal invasion, multifocality, calcifications, loss of cellular polarity/cohesiveness (LOP/C) in the invasive front, CLNM and LLNM, and retrospectively analysis...
January 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28109462/can-ratio-of-the-biggest-tumor-diameter-to-total-tumor-diameter-be-a-new-parameter-in-the-differential-diagnosis-of-agressive-and-favorable-multifocal-papillary-thyroid-microcarcinoma
#15
Abbas Ali Tam, Didem Özdemir, Neslihan Çuhacı, Hüsniye Başer, Ahmet Dirikoç, Cevdet Aydın, Aylin Kılıç Yazgan, Reyhan Ersoy, Bekir Çakır
OBJECTIVES: In this study, we aimed to evaluate the usefulness of a new parameter -ratio of the biggest tumor diameter to total tumor diameter- for the differentiation of agressive and favorable papillary thyroid microcarcinomas (PTMC). MATERIALS AND METHODS: The diameter of the biggest tumor focus was taken as the primary tumor diameter. Total tumor diameter was calculated as the sum of the maximal diameter of each lesion. Ratio of primary tumor diameter to total tumor diameter was defined as tumor diameter ratio (TDR)...
February 2017: Oral Oncology
https://www.readbyqxmd.com/read/28089996/a-comparison-of-lobectomy-and-total-thyroidectomy-in-patients-with-papillary-thyroid-microcarcinoma-a-retrospective-individual-risk-factor-matched-cohort-study
#16
COMPARATIVE STUDY
Hyemi Kwon, Min Ji Jeon, Won Gu Kim, Suyeon Park, Mijin Kim, Dong Eun Song, Tae-Yon Sung, Jong Ho Yoon, Suck Joon Hong, Tae Yong Kim, Young Kee Shong, Won Bae Kim
OBJECTIVE: Papillary thyroid microcarcinoma (PTMC) accounts for most of the increase in thyroid cancer in recent decades. We compared clinical outcomes and surgical complications of lobectomy and total thyroidectomy (TT) in PTMC patients. DESIGN AND METHODS: In this retrospective individual risk factor-matched cohort study, 2031 patients with PTMC were initially included. Patients who underwent lobectomy or TT were one-to-one matched according to individual risk factors, including age, sex, primary tumor size, extrathyroidal extension, multifocality and cervical lymph node (LN) metastasis...
April 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28087101/current-management-of-low-risk-differentiated-thyroid-cancer-and-papillary-microcarcinoma
#17
V D Tarasova, R M Tuttle
Each year, the proportion of thyroid cancer patients presenting with low risk disease is increasing. Moreover, the definition of low risk thyroid cancer is expanding and several histological subtypes beyond papillary microcarcinomas are now classified as low risk disease. This shift in the landscape of thyroid cancer presentation is forcing clinicians to critically re-evaluate whether or not traditional management paradigms that were effective in treating intermediate and high risk disease are applicable to these low risk patients...
January 10, 2017: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/28077340/clinicopathological-characteristics-of-papillary-thyroid-cancer-in-children-with-emphasis-on-the-pubertal-status-and-association-with-brafv600e-mutation
#18
Şükran Poyrazoğlu, Rüveyde Bundak, Firdevs Baş, Gülçin Yeğen, Yasemin Şanlı, Feyza Darendeliler
OBJECTIVE: Papillary thyroid cancer (PTC) could behave differently in prepubertal than in pubertal children and between children and adults. BRAF gene activating mutations may associate with PTC by creating aberrant activation. We aimed to evaluate clinicopathological characteristics of PTC patients with emphasis on the pubertal status and investigate the association of BRAFV600E mutation with disease characteristics. METHODS: Medical records of 75 patients with PTC were reviewed retrospectively...
January 12, 2017: Journal of Clinical Research in Pediatric Endocrinology
https://www.readbyqxmd.com/read/28054188/predictive-factors-for-active-surveillance-of-subcentimeter-thyroid-nodules-with-highly-suspicious-us-features
#19
Hye Mi Gweon, Eun Ju Son, Jeong-Ah Kim, Ji Hyun Youk
PURPOSE: This study was designed to assess the outcomes of subcentimeter thyroid nodules with highly suspicious ultrasonography (US) features and to investigate the predictive factors associated with malignancy and aggressive biological behavior to determine appropriate candidate factors for active surveillance. METHODS: Between June 2011 and December 2013, 1866 subcentimeter thyroid nodules with highly suspicious US features that were subjected to US-guided fine needle aspiration and subsequent surgery or US follow-up of at least 2 years were evaluated...
January 4, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28017809/prevalence-of-contralateral-tumors-in-patients-with-follicular-variant-of-papillary-thyroid-cancer
#20
Michael C Sullivan, Paul H Graham, Erik K Alexander, Daniel T Ruan, Matthew A Nehs, Atul A Gawande, Francis D Moore, Brooke E Howitt, Kyle C Strickland, Jeffrey F Krane, Justine A Barletta, Nancy L Cho
BACKGROUND: Thyroid lobectomy alone is being performed increasingly for patients with encapsulated follicular variant of papillary thyroid carcinoma (fvPTC). However, the prevalence of contralateral disease in these patients is unknown. We investigated the presence of synchronous disease in fvPTC to improve decision making about the extent of surgical resection and need for surveillance. STUDY DESIGN: We performed a retrospective review of patients who underwent thyroid surgery from October 2009 to February 2013 with a diagnosis of fvPTC as their primary lesion...
December 23, 2016: Journal of the American College of Surgeons
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