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papillary thyroid microcarcinoma

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https://www.readbyqxmd.com/read/29344271/clinical-pathological-characteristics-and-prognostic-factors-for-papillary-thyroid-microcarcinoma-in-the-elderly
#1
Jing Tang, Hans B Liu, Lujiao Yu, Xin Meng, Sean X Leng, Haiyan Zhang
Background: The incidence of papillary thyroid microcarcinoma (PTMC) has increased dramatically over the past three decades worldwide. The annual rate of increase in the elderly (≥65) PTMC patients is 1.4 times higher than that in the adult (<65) PTMC patients. The aim of the present study is to identify the clinical-pathological characteristics and prognostic factors in the elderly PTMC patients. Methods: The source population is PTMC patients whose information is available in the Surveillance, Epidemiology and End Results (SEER) database (2004-2013)...
2018: Journal of Cancer
https://www.readbyqxmd.com/read/29340156/hepatotoxicity-in-hyperthyroid-patient-after-consecutive-methimazole-and-propylthiouracil-therapies
#2
Fernando Gomez-Peralta, Pablo Velasco-Martínez, Cristina Abreu, María Cepeda, Marta Fernández-Puente
Methimazole (MMI) and propylthiouracil (PTU) are widely used antithyroid drugs (ATD) that have been approved for the treatment of hyperthyroidism. Hepatotoxicity may be induced by these drugs, though they exert dissimilar incidence rates of hepatotoxicity and, possibly, with different underlying pathogenic mechanisms. We report the case of a 55-year-old woman with no relevant medical history diagnosed with hyperthyroidism due to Graves' disease, who developed two episodes of acute hepatitis concurrent with the consecutive administration of two different ATDs, first MMI and then PTU...
2018: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/29324353/dietary-habits-during-the-2-months-following-the-chernobyl-accident-and-differentiated-thyroid-cancer-risk-in-a-population-based-case-control-study
#3
Constance Xhaard, Carole Rubino, Vincent Souchard, Stéphane Maillard, Yan Ren, Françoise Borson-Chazot, Geneviève Sassolas, Claire Schvartz, Marc Colonna, Brigitte Lacour, Anne Sophie Woronoff, Michel Velten, Emilie Marrer, Laurent Bailly, Eugènia Mariné Barjoan, Martin Schlumberger, Vladimir Drozdovitch, Andre Bouville, Jacques Orgiazzi, Elisabeth Adjadj, Florent de Vathaire
BACKGROUND: The Chernobyl nuclear power plant accident occurred in Ukraine on April 26th 1986. In France, the radioactive fallout and thyroid radiation doses were much lower than in highly contaminated areas. However, a number of risk projections have suggested that a small excess in differentiated thyroid cancer (DTC) might occur in eastern France due to this low-level fallout. In order to investigate this potential impact, a case-control study on DTC risk factors was started in 2005, focusing on cases who were less than 15 years old at the time of the Chernobyl accident...
January 8, 2018: Cancer Epidemiology
https://www.readbyqxmd.com/read/29322881/radiofrequency-ablation-of-primary-thyroid-carcinoma-efficacy-according-to-the-types-of-thyroid-carcinoma
#4
So Yeong Jeong, Jung Hwan Baek, Young Jun Choi, Sae Rom Chung, Tae Yon Sung, Won Gu Kim, Tae Yong Kim, Jeong Hyun Lee
OBJECTIVE: To evaluate the efficacy of ultrasound (US)-guided radiofrequency ablation (RFA) according to the types of thyroid carcinoma, particularly in patients with a high surgical risk. MATERIALS AND METHODS: Eight patients with nine tumors of pathologically proven papillary and anaplastic carcinoma were treated by US-guided RFA. Patients with primary thyroid carcinoma were divided into three groups; group 1: Anaplastic carcinoma, group 2: papillary macrocarcinoma, and group 3: papillary microcarcinoma...
January 11, 2018: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/29313264/positivity-for-gata3-and-ttf-1-spt24-and-negativity-for-monoclonal-pax8-expand-the-biomarker-profile-of-the-solid-cell-nests-of-the-thyroid-gland
#5
Hasan Gucer, Ozgur Mete
Solid cell nests (SCNs) are usually distinguished on conventional H&E-stained sections; however, the morphological heterogeneity in SCNs and hyperplasia of these ultimobranchial body remnants can mimic other diagnostic entities including but not limited to papillary microcarcinoma. In order to confirm the thyroid follicular epithelial origin and exclude the possibility of SCNs, most diagnosticians use immunohistochemical biomarkers of thyroid follicular epithelial cells and/or those of SCNs. While the expression profile of monoclonal PAX8 has not been reported previously in SCNs, the status of TTF-1 expression using the 8G7G3/1 clone has been inconsistent among several studies...
January 8, 2018: Endocrine Pathology
https://www.readbyqxmd.com/read/29306230/prediction-of-central-lymph-node-metastasis-in-patientswith-thyroid-papillary-microcarcinoma
#6
Şafak Akın, Duygu Yazgan Aksoy, Serkan Akın, Mehmet Kılıç, Fahri Yetişir, Miyase Bayraktar
Background/aim: The purpose of this study was to analyze the clinicopathological characteristics of patients with papillary thyroid carcinoma (PTC) and papillary thyroid microcarcinoma (PTMC) and predictive factors for central lymph node metastasis (CLNM).Materials and methods: Patients diagnosed as having PTC and PTMC were evaluated. Clinical and laboratory parameters were recorded.Results: The mean age at diagnosis was 47.3 +- 11.9 years. Of all 223 patients, 91 (40.8%) had lymph nodes removed, 29 of whom had lymph node metastasis and 24 of whom had only CLNM...
December 19, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29305632/-surgery-of-papillary-thyroid-microcarcinoma
#7
REVIEW
T Weber, S Peth, R Hummel
BACKGROUND: Different countries are currently reporting a substantial increase in the incidence rates of papillary thyroid microcarcinoma (PTMC). OBJECTIVE: Presentation of diagnosis and surgical therapy of PTMC and discussion of a more conservative approach, such as active surveillance. MATERIAL AND METHODS: Overview of the current guidelines from different countries and analysis of recent publications reporting the results of active surveillance of PTMC from Japan, Korea and the USA...
January 5, 2018: Der Chirurg; Zeitschrift Für Alle Gebiete der Operativen Medizen
https://www.readbyqxmd.com/read/29302495/modified-transoral-endoscopic-thyroid-surgery-for-treatment-of-thyroid-cancer-operative-steps-and-video
#8
Xiao-Wei Peng, Hui Li, Zan Li, Xiao Zhou, Da-Jiang Song, Bo Zhou, Chun-Liu Lv, Wen Peng
In this video we describe a kind of modified transoral endoscopic thyroid surgery involving meticulous dissection of mental nerve. Inclusion criteria are: the diameter of benign tumors such as thyroid cyst, nodular goiter were limited less than 50 mm; the malignant thyroid tumors including follicular and papillary microcarcinoma were defined as a papillary carcinoma <2 cm in diameter and endoscopic surgery required for the patient. A 6 cm arc-shaped incision was designed at oral vestibule. The branches of mental nerves at both sides were identified and exposed carefully...
December 2017: Gland Surgery
https://www.readbyqxmd.com/read/29273943/thyroid-disease-in-children-and-adolescents-with-pten-hamartoma-tumor-syndrome-phts
#9
Michaela Plamper, Felix Schreiner, Bettina Gohlke, Janina Kionke, Eckard Korsch, James Kirkpatrick, Mark Born, Stefan Aretz, Joachim Woelfle
Patients with PTEN hamartoma tumor syndrome (PHTS) are at increased risk of developing benign and malignant tumors, including thyroid carcinoma. Benign thyroid lesions and single cases of thyroid carcinoma have been reported in children with PHTS. We conducted a retrospective, single-centered study including children and adolescents with a molecularly proven diagnosis of PTEN. Our cohort consists of 16 patients, with a mean age at diagnosis PHTS of 5.7 years. Twelve of 16 cases exhibited thyroid abnormalities (75%)...
December 22, 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/29229118/clinical-predictors-of-lymph-node-metastasis-and-survival-rate-in-papillary-thyroid-microcarcinoma-analysis-of-3607-patients-at-a-single-institution
#10
Yanan Xu, Le Xu, Jiadong Wang
BACKGROUND: The treatment of papillary thyroid microcarcinoma (PTMC) patients is controversial, as PTMC is often found incidentally and its prognosis is quite good. Because lymph node metastasis (LNM) is one of the main predictors of recurrence and impacts the survival rate of PTMC patients, this study aims to retrospectively identify the clinical factors that increase the risk of LNM and/or recurrence and can then be used to separate clinically unfavorable PTMCs from the rest and to help guide their treatment accordingly...
January 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29211863/high-serum-tsh-level-is-associated-with-progression-of-papillary-thyroid-microcarcinoma-during-active-surveillance
#11
Hye In Kim, Hye Won Jang, Hyeon Seon Ahn, Soohyun Ahn, So Young Park, Young Lyun Oh, Soo Yeon Hahn, Jung Hee Shin, Jung-Han Kim, Jee Soo Kim, Jae Hoon Chung, Tae Hyuk Kim, Sun Wook Kim
Objective: Thyroid-stimulating hormone (TSH) is a growth factor affecting initiation or progression of papillary thyroid cancer (PTC), which supports TSH suppressive therapy in PTC patients. In patients with papillary thyroid microcarcinoma (PTMC) during active surveillance, however, the association between serum TSH level and growth of PTMC has not been demonstrated. Patients: We analyzed 127 PTMCs in 126 patients under active surveillance with serial serum TSH measurement and ultrasonography...
December 1, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29204912/should-subcentimeter-non-invasive-encapsulated-follicular-variant-of-papillary-thyroid-carcinoma-be-included-in-the-noninvasive-follicular-thyroid-neoplasm-with-papillary-like-nuclear-features-category
#12
Bin Xu, Nada Farhat, Justine A Barletta, Yin P Hung, Dario de Biase, Gian Piero Casadei, Ayse Mine Onenerk, R Michael Tuttle, Benjamin R Roman, Nora Katabi, Vania Nosé, Peter Sadow, Giovanni Tallini, William C Faquin, Ronald Ghossein
OBJECTIVE: In 2016, non-invasive, well-circumscribed and encapsulated, follicular variant of papillary thyroid carcinoma (NI-EFV PTC) was reclassified as noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) in order to reduce overtreatment of this indolent tumor. However, the study cohort did not include subcentimeter tumors, i.e., papillary thyroid microcarcinoma (mPTC) with NI-EFV morphology, and such lesions are still regarded and staged by most pathologists as microcarcinomas...
December 4, 2017: Endocrine
https://www.readbyqxmd.com/read/29165886/pre-operative-features-of-non-invasive-follicular-thyroid-neoplasms-with-papillary-like-nuclear-features-an-analysis-of-their-cytological-gene-expression-classifier-and-sonographic-findings
#13
S J Song, V A LiVolsi, K Montone, Z Baloch
OBJECTIVE: To investigate the corresponding cytological diagnoses, Gene Expression Classifier (GEC) results and ultrasound features of thyroid nodules diagnosed as non-invasive follicular thyroid neoplasms with papillary-like nuclear features (NIFTP), as well as any coexisting pathology. METHODS: We performed a retrospective review of thyroid nodules histologically diagnosed as NIFTP at our institution between 1st April 2016 and 1st April 2017. The following data points were collected: demographics, nodule size, ultrasound features, cytological diagnosis, GEC results, origin of sample (in-house vs outside hospital) and any additional pathology identified in the resection specimen...
December 2017: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://www.readbyqxmd.com/read/29164514/high-urinary-iodine-thyroid-autoantibodies-and-thyroid-stimulating-hormone-for-papillary-thyroid-cancer-risk
#14
Hengqiang Zhao, Hehe Li, Tao Huang
Thyroid nodules have become a common clinical problem, and the clinical importance of thyroid nodules lies in the determination of thyroid cancer. This study aims to evaluate the risk factors for papillary thyroid cancer (PTC) with regard to urinary iodine concentration (UIC), thyroid-stimulating hormone (TSH), thyroid peroxidase antibody (TPOAb), and thyroglobulin antibody (TGAb) in comparison to thyroid nodular goiter (NG). Among the 2041 patients, 43.8% of which showed more than adequate (UIC 200-299 μg/L) and excessive iodine (UIC ≥ 300...
November 21, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/29137384/mir-324-5p-assists-ultrasonography-in-predicting-lymph-node-metastasis-of-unifocal-papillary-thyroid-microcarcinoma-without-extracapsular-spread
#15
Yanhua Yang, Shujun Xia, Xiaofeng Ni, Zhongxin Ni, Lu Zhang, Wenhan Wang, Yanjun Kong, Yan Wang, Lei Ye, Weiwei Zhan
Ultrasonography is the first choice of lymph node metastasis (LNM) detection which is crucial for therapeutic options of papillary thyroid cancer (PTC). However, the sensitivity of ultrasonography in detecting LNM of PTC is relatively low; especially in central LNM. MiR-324-5p has been reported to play important roles in the metastasis of various cancers. To explore the relationship between miR-324-5p and LNM in PTC, quantitative real-time polymerase chain reaction was performed in PTC tissue and fine needle aspiration (FNA) washout successively...
October 13, 2017: Oncotarget
https://www.readbyqxmd.com/read/29120119/cyclin-d1-ret-and-p27-expression-in-papillary-thyroid-microcarcinoma
#16
Ana Barić, Vinko Marković, Davor Eterović, Vladimir Bedeković, Mirko Kontić, Ljubica Juretić Kuščić, Valdi Pešutić Pisac, Ante Punda
Th e aim of the study was to determine the influence of RET, p27 and cyclin D1 on regional lymph node metastases in papillary microcarcinoma. The analysis included 70 patients with papillary thyroid microcarcinoma that underwent surgery at Split University Hospital Center between 1999 and 2001. Immunohistochemistry was performed on formalin-fixed, paraffin-embedded tissue by the RET, p27 and cyclin D1 antibodies. Quantification was based on the intensity and distribution of nuclear staining, dividing tumors into those that showed expression (expressors) and those that showed no expression (non-expressors)...
March 2017: Acta Clinica Croatica
https://www.readbyqxmd.com/read/29106792/novel-insights-in-ultrasound-evaluation-of-thyroid-gland-in-children-with-papillary-thyroid-carcinoma
#17
(no author information available yet)
BACKGROUND: The coincidence of autoimmune thyroiditis (AIT) in patients with papillary thyroid carcinoma (PTC) is ranging between 10 and 58% in the general population. MATERIAL AND METHODS: In the present study retrospective ultrasound, clinical and autoimmune assessment of 24 patients diagnosed with papillary thyroid carcinoma between 2000-2016 was performed. RESULTS: The coexistence of PTC and AIT was found in 50% of patients with PTC. Patients were divided into two groups...
October 6, 2017: Neuro Endocrinology Letters
https://www.readbyqxmd.com/read/29103582/estimation-of-the-lifetime-probability-of-disease-progression-of-papillary-microcarcinoma-of-the-thyroid-during-active-surveillance
#18
Akira Miyauchi, Takumi Kudo, Yasuhiro Ito, Hitomi Oda, Hisanori Sasai, Takuya Higashiyama, Mitsuhiro Fukushima, Hiroo Masuoka, Minoru Kihara, Akihiro Miya
BACKGROUND: We reported that a minority of patients with low-risk papillary microcarcinoma of the thyroid showed disease progression during active surveillance and that older patients had significantly lower disease progression rates than younger patients. Here, we estimated lifetime (≤85 years old) probabilities of disease progression during active surveillance according to the age at presentation based on age decade-specific disease progression rates. METHODS: From 1993-2013, 1,211 low-risk papillary microcarcinoma patients aged 20-79 years underwent active surveillance at Kuma Hospital...
November 2, 2017: Surgery
https://www.readbyqxmd.com/read/29099711/braf-antibody-expression-in-different-types-of-thyroid-nodular-lesions
#19
E Barabadze, V Munjishvili, G Burkadze
Major problems haunt the physicians who need to delineate the best management strategy for their patients with thyroid nodule is the identification of the most aggressive cases, especially among papillary thyroid cancers, which would benefit from more aggressive therapy and follow up. Beyond its strong correlation with PTC, the BRAF mutation is well described to associate with poor prognosis. The aim of our study was to identify BRAF antibody expression in different hystotypes of the thyroid nodules and assessment of it expression according to the tumor aggressiveness...
October 2017: Georgian Medical News
https://www.readbyqxmd.com/read/29070029/skip-metastasis-in-papillary-thyroid-carcinoma-is-difficult-to-predict-in-clinical-practice
#20
Xilin Nie, Zhou Tan, Minghua Ge
BACKGROUND: Cervical lymph node metastases are very common in papillary thyroid cancer (PTC), and typically spread in a predictable stepwise fashion in clinical practice. However, lateral lymph node metastasis (LLNM) without central lymph node metastasis (CLNM) as skip metastasis is not rare in PTC. The aim of this study was to investigate the incidence, risk factors and pattern of skip metastasis in PTC. METHODS: A total of 271 patients with PTC and suspicious LLN diagnosed by pre-operation examinations who underwent total thyroidectomy and central lymph node dissection plus lateral lymph node dissection between January 2008 and December 2011 were enrolled in this study...
October 25, 2017: BMC Cancer
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