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papillary thyroid microcarcinoma

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https://www.readbyqxmd.com/read/29137384/mir-324-5p-assists-ultrasonography-in-predicting-lymph-node-metastasis-of-unifocal-papillary-thyroid-microcarcinoma-without-extracapsular-spread
#1
Yanhua Yang, Shujun Xia, Xiaofeng Ni, Zhongxin Ni, Lu Zhang, Wenhan Wang, Yanjun Kong, Yan Wang, Lei Ye, Weiwei Zhan
Ultrasonography is the first choice of lymph node metastasis (LNM) detection which is crucial for therapeutic options of papillary thyroid cancer (PTC). However, the sensitivity of ultrasonography in detecting LNM of PTC is relatively low; especially in central LNM. MiR-324-5p has been reported to play important roles in the metastasis of various cancers. To explore the relationship between miR-324-5p and LNM in PTC, quantitative real-time polymerase chain reaction was performed in PTC tissue and fine needle aspiration (FNA) washout successively...
October 13, 2017: Oncotarget
https://www.readbyqxmd.com/read/29120119/cyclin-d1-ret-and-p27-expression-in-papillary-thyroid-microcarcinoma
#2
Ana Barić, Vinko Marković, Davor Eterović, Vladimir Bedeković, Mirko Kontić, Ljubica Juretić Kuščić, Valdi Pešutić Pisac, Ante Punda
Th e aim of the study was to determine the influence of RET, p27 and cyclin D1 on regional lymph node metastases in papillary microcarcinoma. The analysis included 70 patients with papillary thyroid microcarcinoma that underwent surgery at Split University Hospital Center between 1999 and 2001. Immunohistochemistry was performed on formalin-fixed, paraffin-embedded tissue by the RET, p27 and cyclin D1 antibodies. Quantification was based on the intensity and distribution of nuclear staining, dividing tumors into those that showed expression (expressors) and those that showed no expression (non-expressors)...
March 2017: Acta Clinica Croatica
https://www.readbyqxmd.com/read/29106792/novel-insights-in-ultrasound-evaluation-of-thyroid-gland-in-children-with-papillary-thyroid-carcinoma
#3
(no author information available yet)
BACKGROUND: The coincidence of autoimmune thyroiditis (AIT) in patients with papillary thyroid carcinoma (PTC) is ranging between 10 and 58% in the general population. MATERIAL AND METHODS: In the present study retrospective ultrasound, clinical and autoimmune assessment of 24 patients diagnosed with papillary thyroid carcinoma between 2000-2016 was performed. RESULTS: The coexistence of PTC and AIT was found in 50% of patients with PTC. Patients were divided into two groups...
October 6, 2017: Neuro Endocrinology Letters
https://www.readbyqxmd.com/read/29103582/estimation-of-the-lifetime-probability-of-disease-progression-of-papillary-microcarcinoma-of-the-thyroid-during-active-surveillance
#4
Akira Miyauchi, Takumi Kudo, Yasuhiro Ito, Hitomi Oda, Hisanori Sasai, Takuya Higashiyama, Mitsuhiro Fukushima, Hiroo Masuoka, Minoru Kihara, Akihiro Miya
BACKGROUND: We reported that a minority of patients with low-risk papillary microcarcinoma of the thyroid showed disease progression during active surveillance and that older patients had significantly lower disease progression rates than younger patients. Here, we estimated lifetime (≤85 years old) probabilities of disease progression during active surveillance according to the age at presentation based on age decade-specific disease progression rates. METHODS: From 1993-2013, 1,211 low-risk papillary microcarcinoma patients aged 20-79 years underwent active surveillance at Kuma Hospital...
November 2, 2017: Surgery
https://www.readbyqxmd.com/read/29099711/braf-antibody-expression-in-different-types-of-thyroid-nodular-lesions
#5
E Barabadze, V Munjishvili, G Burkadze
Major problems haunt the physicians who need to delineate the best management strategy for their patients with thyroid nodule is the identification of the most aggressive cases, especially among papillary thyroid cancers, which would benefit from more aggressive therapy and follow up. Beyond its strong correlation with PTC, the BRAF mutation is well described to associate with poor prognosis. The aim of our study was to identify BRAF antibody expression in different hystotypes of the thyroid nodules and assessment of it expression according to the tumor aggressiveness...
October 2017: Georgian Medical News
https://www.readbyqxmd.com/read/29070029/skip-metastasis-in-papillary-thyroid-carcinoma-is-difficult-to-predict-in-clinical-practice
#6
Xilin Nie, Zhou Tan, Minghua Ge
BACKGROUND: Cervical lymph node metastases are very common in papillary thyroid cancer (PTC), and typically spread in a predictable stepwise fashion in clinical practice. However, lateral lymph node metastasis (LLNM) without central lymph node metastasis (CLNM) as skip metastasis is not rare in PTC. The aim of this study was to investigate the incidence, risk factors and pattern of skip metastasis in PTC. METHODS: A total of 271 patients with PTC and suspicious LLN diagnosed by pre-operation examinations who underwent total thyroidectomy and central lymph node dissection plus lateral lymph node dissection between January 2008 and December 2011 were enrolled in this study...
October 25, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29061158/correction-to-influence-of-tumor-extent-on-central-lymph-node-metastasis-in-solitary-papillary-thyroid-microcarcinomas-a-retrospective-study-of-1092-patients
#7
Xingjie Yin, Chunping Liu, Yawen Guo, Xiaoyu Li, Na Shen, Xiangwang Zhao, Pan Yu, Shan Wang, Zeming Liu
No abstract text is available yet for this article.
October 17, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29039144/transoral-endoscopic-thyroidectomy-via-a-vestibular-approach-why-and-how
#8
Gianlorenzo Dionigi, Young Jun Chai, Ralph P Tufano, Angkoon Anuwong, Hoon Yub Kim
The transoral endoscopic thyroidectomy vestibular approach (TOETVA) is a novel, scar-free surgical procedure that does not require visible incisions. Indications for TOETVA are as follows: predicted gland width on diagnostic imaging ≤10 cm; a thyroid volume outline of <45 mL or dominant nodule dimension of ≤50 mm; three or four Bethesda lesions; a primary papillary microcarcinoma without local or distant metastasis; and patient request for optimal esthetic results. Contraindications are as follows: patients unfit for general anesthesia; precedent radiation in the head, neck, upper mediastinum; antecedent neck surgery; recurrent goiter; a gland volume of >45 mL or main nodule diameter of >50 mm; and documentation of lymph node or distant metastases, tracheal/esophageal infiltration, preoperative laryngeal nerve palsy, hyperthyroidism, mediastinal goiter, or an oral abscess...
October 16, 2017: Endocrine
https://www.readbyqxmd.com/read/29029476/contrastive-study-of-two-screening-criteria-for-active-surveillance-in-patients-with-low-risk-papillary-thyroid-microcarcinoma-a-retrospective-analysis-of-1001-patients
#9
Kai Qian, Kai Guo, Xiaoke Zheng, Tuanqi Sun, Duanshu Li, Yi Wu, Qinghai Ji, Zhuoying Wang
Screening out patients who do not require immediate surgery is a growing trend in the field of thyroid research. In this study, we retrospectively compared the application of two surveillance selection criteria in 1001 patients who had undergone surgical treatment of papillary thyroid microcarcinoma (PTMC): low-risk PTMC characteristics defined by Kuma Hospital and CATO consensus on PTMC management of active surveillance. Treatment outcomes were compared between groups. We then analyzed the prognostic indicators of patients who could be managed by surveillance...
September 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/28985856/papillary-thyroid-microcarcinoma-decision-making-extent-of-surgery-and-outcomes
#10
Amanda K Price, Reese W Randle, David F Schneider, Rebecca S Sippel, Susan C Pitt
BACKGROUND: The optimal extent of surgery for patients with papillary thyroid microcarcinoma (PTMC), tumors ≤1 cm, is controversial because survival is excellent regardless of approach. The objective of this study was to investigate patient and surgeon decision-making about the extent of surgery for PTMC. MATERIALS AND METHODS: We conducted a retrospective review of thyroid cancer patients operated on at a single institution from 2008-2016. To examine decision-making about the extent of surgery, we performed a discourse analysis on all available documentation looking for patient or surgeon reasons...
October 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/28977162/serum-ghrelin-levels-in-papillary-thyroid-carcinoma
#11
Bekir Ucan, Mustafa Sahin, Muhammed Kizilgul, Mustafa Ozbek, Seyda Ozdemir, Mustafa Calıskan, Erman Cakal
OBJECTIVE: Ghrelin plays a role in several processes of cancer progression, and numerous cancer types express ghrelin and its receptor. We aimed to investigate serum levels of ghrelin in patients with papillary thyroid carcinoma (PTC) and its association with the prognostic factors in PTC. MATERIALS AND METHODS: We enrolled 54 patients with thyroid cancer (7 male, 47 female) and 24 healthy controls (6 male, 18 female) in the study. We compared demographic, anthropometric, and biochemical data, and serum ghrelin levels between the groups...
September 18, 2017: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28975988/risk-factors-for-predicting-central-lymph-node-metastasis-in-papillary-thyroid-microcarcinoma-cn0-a-study-of-273-resections
#12
M Li, X-Y Zhu, J Lv, K Lu, M-P Shen, Z-L Xu, Z-S Wu
OBJECTIVE: The role of routine central lymph node dissection (CLND) for clinically central lymph node negative (CN0) papillary thyroid microcarcinoma (PTMC) remains uncertain. We aim to determine the predictive factors for central lymph node metastasis (CLNM) in papillary thyroid microcarcinoma. PATIENTS AND METHODS: A total of 273 patients diagnosed with clinically central lymph node negative PTMC from 2014 to 2016 were included. The predictive risk factors for CLNM were analyzed with respect to age, sex, tumor size, tumor multifocal, lymphadenectasis of lateral neck, capsular invasion, extra capsular spread (ECS), coexistence of chronic lymphocytic thyroiditis (Hashimoto thyroiditis, HT) and nodular goiter (NG), BRAFV600E mutation and subtype of papillary thyroid carcinoma (PTC)...
October 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28964693/hashimoto-s-thyroiditis-an-independent-risk-factor-for-papillary-carcinoma
#13
Barbora Uhliarova, Andrej Hajtman
INTRODUCTION: The link between Hashimoto's thyroiditis (HT) and thyroid carcinoma (TC) has long been a topic of controversy. OBJECTIVE: The aim of our study was to determine the prevalence of TC and HT coexistence in histopathologic material of thyroidectomized patients. METHODS: In a retrospective study, the clinicohistopathologic data of 2117 patients (1738 females/379 males), who underwent total or partial thyroidectomy for thyroid gland disorder at a single institution from the 1st of January 2005 to the 31st of December 2014 were analyzed...
September 14, 2017: Brazilian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/28948061/2016-chinese-expert-consensus-and-guidelines-for-the-diagnosis-and-treatment-of-papillary-thyroid-microcarcinoma
#14
Ming Gao, Minghua Ge, Qinghai Ji, Ruochuan Cheng, Hankui Lu, Haixia Guan, Li Gao, Zhuming Guo, Tao Huang, Xiaoming Huang, Xiaoming Li, Yansong Lin, Qinjiang Liu, Xin Ni, Yi Pan, Jianwu Qin, Zhongyan Shan, Hui Sun, Xudong Wang, Zhengang Xu, Yang Yu, Daiwei Zhao, Naisong Zhang, Sheng Zhang, Ying Zheng, Jingqiang Zhu, Dapeng Li, Xiangqian Zheng, Chinese Association Of Thyroid Oncology Cato Chinese Anti-Cancer Association
No abstract text is available yet for this article.
August 2017: Cancer Biology & Medicine
https://www.readbyqxmd.com/read/28924477/a-new-paradigm-in-low-risk-papillary-microcarcinoma-active-surveillance
#15
Alex González Bóssolo, Michelle Mangual Garcia, Paula Jeffs González, Miosotis Garcia, Guillermo Villarmarzo, Jose Hernán Martinez
Classical papillary thyroid microcarcinoma (PTMC) is a variant of papillary thyroid carcinoma (PTC) known to have excellent prognosis. It has a mortality of 0.3%, even in the presence of distance metastasis. The latest American Thyroid Association guidelines state that although lobectomy is acceptable, active surveillance can be considered in the appropriate setting. We present the case of a 37-year-old female with a history of PTMC who underwent surgical management consisting of a total thyroidectomy. Although she has remained disease-free, her quality of life has been greatly affected by the sequelae of this procedure...
2017: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/28900207/reevaluating-the-prognostic-significance-of-male-gender-for-papillary-thyroid-carcinoma-and-microcarcinoma-a-seer-database-analysis
#16
Chunping Liu, Tianwen Chen, Wen Zeng, Shuntao Wang, Yiquan Xiong, Zeming Liu, Tao Huang
The prognostic significance of gender remains controversial for papillary thyroid carcinoma (PTC). In this study, we investigated the associations between gender and prognosis in a large cohort of patients with PTC or PTMC that was diagnosed in 2010-2013 and recorded in the Surveillance, Epidemiology, and End Results cancer registry. The mean ± standard deviation duration of survival for all patients with PTC during the study period was 21.47 ± 14.04 months. In Kaplan-Meier analyses of the entire cohort of PTC patients, survival curves for all-cause death and cancer-specific death declined more sharply for men than for women...
September 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28884301/clinical-and-pathologic-predictors-of-central-lymph-node-metastasis-in-papillary-thyroid-microcarcinoma-a-retrospective-cohort-study
#17
C Y Gui, S L Qiu, Z H Peng, M Wang
OBJECTIVE: To identify the clinical and pathological predictors of central lymph node metastasis (CLNM) in patients with clinically lymph node-negative papillary thyroid microcarcinoma (PTMC). MATERIALS AND METHODS: Data pertaining to 541 clinically lymph node-negative PTMC patients who underwent thyroid surgery at the Shanghai General Hospital between January 2010 and December 2013 were retrospectively analyzed. According to histopathological evidence of central lymph node involvement, patients were divided into central lymph node metastasis (CLNM)-positive and CLNM-negative groups; risk factors for CLNM were identified statistically...
September 7, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/28859207/hashimoto-s-thyroiditis-is-an-important-risk-factor-of-papillary-thyroid-microcarcinoma-in-younger-adults
#18
Yujuan Liu, Chengqian Li, Wenjuan Zhao, Yangang Wang
The association between autoimmune thyroid disease and thyroid cancer remains unclear. We performed a matched case-control study to assess the association between Hashimoto's thyroiditis and papillary thyroid microcarcinoma (PTMC). A total of 927 PTMC cases and 927 age- and gender- matched controls selected from the same population were recruited. Odds ratio (OR) with 95% confidence interval (95% CI) was used to assess the strength of the association between Hashimoto's thyroiditis and PTMC. Conditional logistic regression analysis was carried out, and stratified analyses by age, gender and types of thyroid antibodies were also performed...
October 2017: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/28858848/neutrophil-lymphocyte-ratio-nlr-and-platelet-lymphocyte-ratio-plr-may-be-superior-to-c-reactive-protein-crp-for-predicting-the-occurrence-of-differentiated-thyroid-cancer
#19
S Ozmen, O Timur, I Calik, K Altinkaynak, E Simsek, H Gozcu, A Arslan, A Carlioglu
OBJECTIVES: NLR (neutrophil-lymphocyte ratio) and PLR (platelet-lymphocyte ratio) are prognostic markers of differentiated thyroid cancers. In our study, we evaluated NLR, PLR and C-reactive protein (CRP) for predicting the occurence of differentiated thyroid cancer. This is the first study that compares NLR and PLR to C-reactive protein indifferantiated thyroid cancer not only papillary cancer but also folliculer cancer. METHODS: This study includes 51 papillary carcinoma, 42 papillary microcarcinoma and 31 folliculer carcinoma patients attending to our outpatient Endocrinology Clinic at Erzurum Region Training and Research Hospital between 2009 and 2014...
July 1, 2017: Endocrine Regulations
https://www.readbyqxmd.com/read/28835882/transoral-endoscopic-thyroidectomy-for-papillary-thyroid-microcarcinoma-initial-experience-of-a-single-surgeon
#20
Young Jun Chai, Jung Kee Chung, Angkoon Anuwong, Gianlorenzo Dionigi, Hoon Yub Kim, Ki-Tae Hwang, Seung Chul Heo, Ka Hee Yi, Kyu Eun Lee
PURPOSE: Recently, transoral endoscopic thyroidectomy (TOET) is receiving attention because it is regarded as a true minimally invasive surgery in that it does not leave scars on any part of the body and the area of flap dissection is similar to that of open surgery. In this study, we present the surgical procedures and initial outcomes of TOET in the treatment of papillary thyroid microcarcinoma (PTMC) patients. METHODS: The medical records of patients who underwent TOET for PTMC between July 2016 and February 2017 were retrospectively reviewed...
August 2017: Annals of Surgical Treatment and Research
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