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papillary thyroid microcarcinoma

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https://www.readbyqxmd.com/read/27904709/braf-and-epithelial-mesenchymal-transition-in-papillary-thyroid-carcinoma-challenging-the-roles-of-snail-and-e-cadherin
#1
Brendon Mitchell, Dominick Leone, Shi Yang, Ashraf Khan, Meera Mahalingam, Jagdish Dhingra
OBJECTIVE: In papillary thyroid carcinoma (PTC), while the role of BRAF is well established, the contribution of BRAF to epithelial-mesenchymal transition is not. STUDY DESIGN/SETTING: To elucidate the relationship between BRAF, surrogates of epithelial-mesenchymal transition (Snail, E-cadherin) and established histopathologic prognosticators in papillary thyroid carcinoma. SUBJECTS/METHODS: In this IRB approved cross-sectional study, 50 cases of archived annotated PTC samples were retrieved and immunohistochemically stained for Snail and E-cadherin protein...
2016: American Journal of Translational Research
https://www.readbyqxmd.com/read/27885512/clinicopathological-features-of-thyroid-cancer-in-the-elderly-compared-to-younger-counterparts-single-center-experience
#2
F D Dellal, D Özdemir, A A Tam, H Baser, H Tatli Dogan, O Parlak, R Ersoy, B Cakir
PURPOSE: The incidence of thyroid cancer is increased in elderly patients. It tends to be larger and have more aggressive characteristics in these patients. Our aim was to compare features of thyroid carcinoma in geriatric and non-geriatric patients. METHODS: In total, 933 patients with thyroid cancer were retrospectively reviewed. Thyroid functions, ultrasonography features of malignant nodules, cytological and histopathological findings and the rates of recurrence and persistence were compared in patients ≥65 and <65 years old...
November 24, 2016: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/27881018/a-different-prognostic-value-of-brafv600e-mutation-positivity-in-different-age-groups-of-patients-with-papillary-thyroid-cancer
#3
E Takacsova, R Kralik, I Waczulikova, K Zavodna, J Kausitz
The aim of retrospective single-center study was to assess the prognostic value of BRAFV600E mutation positivity (BRAFV600E+) on disease persistence/recurrence in patients with papillary thyroid cancer (PTC). A total of 199 patients having had initial surgery with neck dissection in our hospital between 6/2009-6/2012 were included in the cohort. Excluded were patients with unifocal microcarcinoma ≤1cm. BRAFV600E mutation was tested from formalin-fixed paraffin-embedded surgicaly removed tumors. All included patients were postoperatively treated with radioiodine...
November 24, 2016: Neoplasma
https://www.readbyqxmd.com/read/27853812/ultrasound-guided-percutaneous-laser-ablation-of-unifocal-t1n0m0-papillary-thyroid-microcarcinoma-preliminary-results
#4
Wei Zhou, Shan Jiang, Weiwei Zhan, Jianqiao Zhou, Shangyan Xu, Lu Zhang
OBJECTIVES: To evaluate the efficacy and safety of percutaneous laser ablation (PLA) for unifocal T1N0M0 papillary thyroid microcarcinoma(PTMC). METHODS: A retrospective study was conducted in 30 patients with single PTMC which was diagnosed by fine-needle aspiration biopsy (FNAB). PLA was performed for proper time to achieve adequate ablation zones. The extent of ablation was assessed by contrast-enhanced ultrasound (CEUS) immediately and 7 days after PLA. Complications were recorded...
November 16, 2016: European Radiology
https://www.readbyqxmd.com/read/27843808/therapeutic-strategies-and-clinical-outcome-in-papillary-thyroid-microcarcinoma-a-multicenter-observational-study
#5
F Cecoli, E M Ceresola, V Altrinetti, M Cabria, M Cappagli, A Montepagani, C M Cuttica, U Filippi, D Saverino, M Raffa, M Caputo, F Minuto, M Giusti, M Bagnasco
PURPOSE: Papillary thyroid microcarcinoma (MPTC) has an excellent prognosis. We aimed to evaluate the evolution of therapeutic strategies over time and the clinical outcome of MPTC. METHODS: In this retrospective multicenter observational study in a northwest Italian region, patients with intrathyroidal, unifocal tumor ≤1 cm in size, incidentally found at histology or preoperative cytology diagnosis, were included. Exclusion criteria were a previous head-and-neck irradiation and/or node metastases...
September 2016: European Thyroid Journal
https://www.readbyqxmd.com/read/27835583/non-invasive-diagnosis-of-papillary-thyroid-microcarcinoma-a-nmr-based-metabolomics-approach
#6
Jinghui Lu, Sanyuan Hu, Paolo Miccoli, Qingdong Zeng, Shaozhuang Liu, Lin Ran, Chunxiao Hu
Papillary thyroid microcarcinoma (PTMC) is a subtype of papillary thyroid carcinoma (PTC). Because its diameter is less than 10 mm, diagnosing it accurately is difficult with traditional methods such as image examinations and FNA (Fine Needle Aspiration). Investigating the metabolic changes induced by PTMC may enhance the understanding of its pathogenesis and provide important information for a new diagnosis method and treatment plan. In this study, high resolution magic angle spin (HRMAS) spectroscopy and 1H-nuclear magnetic resonance (1H-NMR) spectroscopy were used to screen metabolic changes in thyroid tissues and plasma from PTMC patients respectively...
November 7, 2016: Oncotarget
https://www.readbyqxmd.com/read/27834461/clinicopathological-significance-of-loss-of-p27kip1-expression-in-papillary-thyroid-carcinoma
#7
Nae Yu Kim, Jin Hwa Kim, Jung-Soo Pyo, Won Jin Cho
INTRODUCTION: A meta-analysis was done to investigate the clinicopathological significance of the loss of p27kip1 expression in papillary thyroid carcinoma (PTC). METHODS: The meta-analysis involving 17 studies included 1,652 PTC and 328 benign cases. The rate of p27kip1 expression loss in PTC and benign lesions, and the correlations between p27kip1 expression loss and clinicopathological characteristics of PTC were determined. RESULTS: The estimated rate of p27kip1 expression loss was 0...
November 5, 2016: International Journal of Biological Markers
https://www.readbyqxmd.com/read/27806783/-clinicopathological-features-of-thyroid-papillary-microcarcinoma-of-which-the-maximum-diameter-is-less-than-5-mm-a-series-of-487-cases
#8
C Chen, H Z Chen, C H Lyu, S Xue, N K Yu, X Chen
Objective: To analyze the clinical and pathological features of papillary thyroid microcarcinoma(PTMC) of which the maximum diameter is less than 5 mm. Methods: Clinical data of 487 PTMC (≤5 mm) patients who underwent primary surgery by the same team of doctors between March 2013 to March 2016 at Department of Surgery, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University were analyzed retrospectively. Female patients accounted for 77.4%(377/487). The age ranged from 22 to 80 years, with an average of (46±11) years...
November 1, 2016: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/27794131/clinicopathologic-factors-and-thyroid-nodule-sonographic-features-for-predicting-central-lymph-node-metastasis-in-papillary-thyroid-microcarcinoma-a-retrospective-study-of-1204-patients
#9
Wen-Han Wang, Shang-Yan Xu, Wei-Wei Zhan
OBJECTIVES: Preoperative prediction of lymph node metastasis is of clinical importance for the surgical treatment of thyroid tumor. The purpose of this study was to evaluate clinicopathologic factors and thyroid nodule sonographic features predictive of central lymph node metastasis in papillary thyroid microcarcinoma. METHODS: Clinicopathologic factors and thyroid nodule sonographic features of 1204 patients with papillary thyroid microcarcinoma were retrospectively reviewed from January 2014 to June 2015...
November 2016: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/27756889/a-meta-analysis-on-the-effect-of-operation-modes-on-the-recurrence-of-papillary-thyroid-microcarcinoma
#10
Dandan Yi, Peng Song, Tao Huang, Xiaoqiao Tang, Jianfeng Sang
Whether total thyroidectomy reduces the recurrence rate in patients with papillary thyroid microcarcinoma (PTMC) is currently controversy. Conclusions of sporadic, inconsistent, and mono-institutional studies need a meta-analysis to evaluate. 525 relevant studies were obtained from initial search on PubMed, 511 studies were excluded by inclusion and exclusion criteria. Eligible data were extracted from each included study. The Odds ratios (ORs) and 95% confidence interval (CI) were used to assess the difference in the recurrence rates between PTMC patients treated with total thyroidectomy and non-total thyroidectomy...
October 15, 2016: Oncotarget
https://www.readbyqxmd.com/read/27749574/is-papillary-thyroid-microcarcinoma-an-indolent-tumor-a-retrospective-study-on-280-cases-treated-with-radioiodine
#11
Xuemei Gao, Xiao Zhang, Yajing Zhang, Wenjuan Hua, Yusufu Maimaiti, Zairong Gao
The increasing detection of papillary thyroid microcarcinoma (PTMC) has created management dilemmas. To clarify the clinical significance of postsurgery stimulated thyroglobulin (ps-Tg) in PTMC who undergo thyroidectomy and radioactive iodine (RAI), we retrospectively reviewed the 358 PTMC patients who were treated with RAI and followed up in our hospital. Those with an excessive anti-Tg antibody, ultrasound-detected residual were excluded, thereby resulting in the inclusion of 280 cases. Their clinical and histopathological information and clinical outcomes were collected and summarized...
October 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27734686/-the-course-of-differentiated-thyroid-microcarcinoma-in-patients-treated-by-different-therapeutic-strategies
#12
Marianna Grigerová, Martin Griger, Emília Mojtová, Ján Podoba
Low risk differentiated thyroid microcarcinoma therapy is a controversial area of thyroid tumor management. Major international medical societies and reputable institutes consider lobectomy to be sufficient therapeutic intervention for the pT1a cN0cM0 stage of papillary thyroid microcarcinoma. However different views and therapeutic strategies exist and result in unnecessary overtreatment and worsening of patients quality of life. We researched the course of the differentiated thyroid microcarcinoma in patients using different therapeutic strategies: lobectomy, total thyroidectomy, total thyroidectomy with central compartment prophylactic lymphadenectomy and total thyroidectomy followed by radioactive iodine treatment...
2016: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/27730092/voluminous-lateral-lymph-node-metastasis-from-papillary-thyroid-microcarcinoma
#13
Ibtissem Oueslati, Karima Khiari, Emna Elfeleh, Néjib Ben Abdallah
No abstract text is available yet for this article.
September 2016: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27704738/the-revised-2016-korean-thyroid-association-guidelines-for-thyroid-nodules-and-cancers-differences-from-the-2015-american-thyroid-association-guidelines
#14
Ka Hee Yi
Increased detection of thyroid nodules using high-resolution ultrasonography has resulted in a world-wide increase in the incidence of differentiated thyroid cancer (DTC). Despite the steep increase in its incidence, the age-standardized mortality rate of thyroid cancer has remained stable, which leads toward a trend of more conservative treatment. The latest American Thyroid Association (ATA) guidelines for thyroid nodules and thyroid cancer revised in 2015 suggested that fine needle aspiration biopsy should be performed for thyroid nodules larger than 1 cm and lobectomy might be sufficient for 1 to 4 cm intrathyroidal DTC...
September 2016: Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27704385/thyroglossal-duct-cyst-carcinomas-a-clinicopathologic-series-of-22-cases-with-staging-recommendations
#15
Lester D R Thompson, Hannah B Herrera, Sean K Lau
Carcinomas arising from thyroglossal duct remnant cysts (TGDCs) are rare, without well-defined management and staging criteria. All TGDCs (n = 685) diagnosed between 2005 and 2015 were retrospectively reviewed, with 22 carcinomas identified (3.2 % incidence). Twenty-two patients (17 females, 5 males), aged 12-64 years (mean 39.9 years; median 39 years) were identified. An anterior, superior midline neck mass was the presenting symptom in all patients. A cancer diagnosis [all papillary thyroid carcinoma (PTC)] was made after the Sistrunk procedure (SP), with a Bethesda Category V or VI classification preoperatively by fine needle aspiration in 5 of 12 cases tested...
October 4, 2016: Head and Neck Pathology
https://www.readbyqxmd.com/read/27698812/ultrasonic-features-of-papillary-thyroid-microcarcinoma-coexisting-with-a-thyroid-abnormality
#16
Bo Li, Yaqiong Zhang, Ping Yin, Jian Zhou, Tian'an Jiang
The present study aimed to investigate the value of ultrasonography in the diagnosis of papillary thyroid microcarcinoma (PTMC) coexisting with a thyroid abnormality, and to improve the accuracy of PTMC diagnosis. The ultrasonic features of 38 PTMC nodules coexisting with a thyroid abnormality and 56 thyroid benign nodules, obtained by surgical resection and confirmed by pathological analysis, were retrospectively analyzed. All masses were ≤ 1.0 cm in diameter. Ultrasonic features that were analyzed included the shape, aspect ratio, boundary, margin, echo, uniformity, presence or absence of microcalcification and enlargement of the lymph nodes, as well as the blood flow of the nodules...
October 2016: Oncology Letters
https://www.readbyqxmd.com/read/27695929/the-extent-of-surgery-for-papillary-thyroid-microcarcinoma-the-controversy-continues
#17
C R McHenry, H Shi
No abstract text is available yet for this article.
September 30, 2016: World Journal of Surgery
https://www.readbyqxmd.com/read/27681413/do-helper-t-cell-subtypes-in-lymphocytic-thyroiditis-play-a-role-in-the-antitumor-effect
#18
Seok Woo Yang, Seong-Ho Kang, Kyung Rae Kim, In Hong Choi, Hang Seok Chang, Young Lyun Oh, Soon Won Hong
BACKGROUND: Papillary thyroid carcinoma (PTC) is frequently accompanied by lymphocytic thyroiditis (LT). Some reports claim that Hashimoto's thyroiditis (the clinical form of LT) enhances the likelihood of PTC; however, others suggest that LT has antitumor activity. This study was aimed to find out the relationship between the patterns of helper T cell (Th) cytokines in thyroid tissue of PTC with or without LT and the clinicopathological manifestation of PTC. METHODS: Fresh surgical samples of PTC with (13 cases) or without (10 cases) LT were used...
September 2016: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/27667647/comparison-of-the-costs-of-active-surveillance-and-immediate-surgery-in-the-management-of-low-risk-papillary-microcarcinoma-of-the-thyroid
#19
Hitomi Oda, Akira Miyauchi, Yasuhiro Ito, Hisanori Sasai, Hiroo Masuoka, Tomonori Yabuta, Mitsuhiro Fukushima, Takuya Higashiyama, Minoru Kihara, Kaoru Kobayashi, Akihiro Miya
The incidence of thyroid cancer is increasing rapidly in many countries, resulting in rising societal costs of the care of thyroid cancer. We reported that the active surveillance of low-risk papillary microcarcinoma had less unfavorable events than immediate surgery, while the oncological outcomes of these managements were similarly excellent. Here we calculated the medical costs of these two managements. We created a model of the flow of these managements, based on our previous study. The flow and costs include the step of diagnosis, surgery, prescription of medicine, recurrence, salvage surgery for recurrence, and care for 10 years after the diagnosis...
September 22, 2016: Endocrine Journal
https://www.readbyqxmd.com/read/27645473/the-incidence-and-risk-factors-for-central-lymph-node-metastasis-in-cn0-papillary-thyroid-microcarcinoma-a-meta-analysis
#20
Liang-Sen Liu, Jia Liang, Jun-Hong Li, Xue Liu, Li Jiang, Jian-Xiong Long, Yue-Ming Jiang, Zhi-Xiao Wei
Although there have been many studies identifying clinical and pathologic factors that may predict central lymph node metastases (CLNM) in papillary thyroid microcarcinoma (PTMC) patients without clinically cervical lymph node metastasis (cN0), the results were inconsistent. And whether prophylactic central lymph node dissection (pCLND) should be performed in cN0 PTMC remains controversial. The EMBASE, PubMed, MEDLINE and the Cochrane Library were searched until Oct 2015 to identify relevant studies. Primary outcomes were clinical and pathologic factors for CLNM...
September 19, 2016: European Archives of Oto-rhino-laryngology
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