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papillary thyroid microcarcinoma

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https://www.readbyqxmd.com/read/28717869/transoral-endoscopic-thyroidectomy-vestibular-approach-toetva-indications-techniques-and-results
#1
Angkoon Anuwong, Thanyawat Sasanakietkul, Pornpeera Jitpratoom, Khwannara Ketwong, Hoon Yub Kim, Gianlorenzo Dionigi, Jeremy D Richmon
INTRODUCTION: The Transoral Neck Surgery (TONS) Study Group was established at the 1st International Thyroid NOTES Conference in February 2016 with the intention of standardizing and refining thyroid NOTES techniques, including both transoral endoscopic and robotic thyroidectomy approaches. Herein, the authors report the modification of indications, preparation, and step-by-step explanations for operative techniques, as well as results and postoperative care for transoral endoscopic thyroidectomy vestibular approach (TOETVA)...
July 17, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28716127/influence-of-tumor-extent-on-central-lymph-node-metastasis-in-solitary-papillary-thyroid-microcarcinomas-a-retrospective-study-of-1092-patients
#2
Xingjie Yin, Chunping Liu, Yawen Guo, Xiaoyu Li, Na Shen, Xiangwang Zhao, Pan Yu, Shan Wang, Zeming Liu
BACKGROUND: The morbidity of papillary thyroid microcarcinomas is increasing worldwide. Surgery is the main treatment for papillary thyroid microcarcinomas, and the choice of surgical method partly depends on the T stage of the tumor. However, according to the American Joint Commission on Cancer staging system (7th edition), the T stage of papillary thyroid microcarcinomas with different tumor extent is unclear. We aimed to study the effect of tumor extent and other factors on central lymph node metastasis to explore the relationship between tumor extent and T stage and to identify the risk factors predicting central lymph node metastasis in papillary thyroid microcarcinomas...
July 17, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28713699/transoral-thyroidectomy-why-is-it-needed
#3
REVIEW
Gianlorenzo Dionigi, Matteo Lavazza, Chei-Wei Wu, Hui Sun, Xiaoli Liu, Ralph P Tufano, Hoon Yub Kim, Jeremy D Richmon, Angkoon Anuwong
Transoral thyroidectomy (TOT) represents reasonably the desirable minimally invasive approach to the gland due to the scarless non-visible incisions, the limited distance between the gland and the access that minimize tissue dissection and respect of the surgical anatomical planes. Patients are routinely selected according to an extensive inclusion criteria: (I) ultrasonographically (US) estimated thyroid diameter not larger than 10 cm; (II) US gland volume ≤45 mL; (III) nodule size ≤50 mm; (IV) a benign tumor, such as a thyroid cyst, single-nodular goiter, or multinodular goiter; (V) follicular neoplasm; (VI) papillary microcarcinoma without lymph node metastasis...
June 2017: Gland Surgery
https://www.readbyqxmd.com/read/28710706/synchronous-and-metastatic-papillary-and-follicular-thyroid-carcinomas-with-unique-molecular-signatures
#4
Vincent Cracolici, Ibro Mujacic, Sabah Kadri, Mir Alikhan, Nifang Niu, Jeremy P Segal, Lauren E Rosen, David H Sarne, Adam Morgan, Samy Desouky, Nicole A Cipriani
Despite the relatively high prevalence of thyroid cancer, the occurrence of multiple synchronous, distinct subtypes of primary thyroid carcinoma is uncommon. The incidental finding of papillary thyroid microcarcinoma in a gland with a biologically relevant follicular or medullary carcinoma is more frequent than the synchronous occurrence of multiple clinically significant carcinomas. We report a case of synchronous papillary and follicular thyroid carcinomas metastatic to lymph node and bone, respectively. Next generation sequencing showed BRAF V600E mutation in the primary papillary carcinoma and NRAS Q61R mutation in the primary follicular carcinoma and bony metastasis...
July 14, 2017: Endocrine Pathology
https://www.readbyqxmd.com/read/28703115/incidental-diagnosis-of-the-tall-cell-variant-of-the-papillary-microcarcinoma-of-the-thyroid-gland-requires-completion-lymphadenectomy-case-report
#5
I Bartella, F Meyer, K Frauenschläger, K Reschke, Th Wallbaum, B Buth, C Bruns, C Chiapponi
Papillary thyroid carcinoma is the most common neoplasm of the thyroid gland which is usually associated with a very good prognosis. The aim of this case report is to present the disease course of a rare tumor of the thyroid gland, which is worthwhile due to its extraordinary appearance and specific management. A 46-year-old patient presented with a pronounced right-sided, but bilateral, multinodular goiter, with a volume of approximately 80 mL, as assessed on ultrasonography. Surgical removal was indicated as scintigraphy showed a 4-cm cold nodule that almost completely took up the right thyroid lobe...
June 30, 2017: Polski Przeglad Chirurgiczny
https://www.readbyqxmd.com/read/28680105/braf-and-nras-mutations-in-papillary-thyroid-carcinoma-and-concordance-in-braf-mutations-between-primary-and-corresponding-lymph-node-metastases
#6
Najla Fakhruddin, Mark Jabbour, Michael Novy, Hani Tamim, Hisham Bahmad, Fadi Farhat, Ghazi Zaatari, Tarek Aridi, Gernot Kriegshauser, Christian Oberkanins, Rami Mahfouz
Concordance between mutations in the primary papillary thyroid carcinoma (PTC) and the paired x lymph node metastasis may elucidate the potential role of molecular targeted therapy in advanced stages. BRAF and NRAS mutations in primary PTC (n = 253) with corresponding metastatic lymph node (n = 46) were analyzed utilizing StripAssays (ViennaLab Diagnostics). Statistical analysis was performed using (SPSS, Inc.), version 24.0 with a p-value of <0.05, and concordance via kappa agreement. BRAF mutation frequency in conventional PTC (cPTC): 56...
July 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28661604/-is-it-necessary-to-perform-a-central-lymphodissection-in-highly-differentiated-iviicrocarcinoiva-of-thyroid-gland
#7
S N Zavgorodniy, M B Danilyuk, A I Rylov, O S Dolya
The rate of the highly differentiated thyroid microcarcinoma methastasizing in central (6th) group of cervical lymph nodes was studied. In the clinic in 2013 - 2015 yrs 62 patients were operated for primary thyroid microcarcinoma. In accordance to TNM (UICC, AJCC, 2009) classification, papillary cancer in stage TlaNOMO was diagnosed in 35 (56.5%) patients, T1aN1MO - in 22 (35.5%); follicular cancer stage T1aNOMO - in 2 (3.2%); papillary cancer, follicular variant in stage T1aN1 MO - in 2 (3.2%); follicu- lar cancer, papillary variant in stage T1aNOMO - in 1 (1...
August 2016: Klinichna Khirurhiia
https://www.readbyqxmd.com/read/28659720/the-genetics-of-papillary-microcarcinomas-of-the-thyroid-diagnostic-and-prognostic-implications
#8
REVIEW
Ana Cunha Rodrigues, Gustavo Penna, Elisabete Rodrigues, Patrícia Castro, Manuel Sobrinho-Simões, Paula Soares
Papillary microcarcinoma of the thyroid (mPTC) is defined by the WHO as a papillary thy-roid cancer measuring 10mm or less in diameter and it is nowadays a topic of intense debate among the members of the medical community due to its apparent "epidemic" rise. Although these tumors follow almost always an indolent clinical course and carry an excellent prognosis, it is known that a small sub-set may display a potentially aggressive behavior. Nevertheless, we still lack an accurate way of predict-ing those which will cause significant disease...
June 2017: Current Genomics
https://www.readbyqxmd.com/read/28642790/therapeutic-outcomes-of-patients-with-multifocal-papillary-thyroid-microcarcinomas-and-larger-tumors
#9
Soh-Ching Ng, Sheng-Fong Kuo, Szu-Tah Chen, Chuen Hsueh, Bie-Yu Huang, Jen-Der Lin
A retrospective review of 626 patients with multifocal papillary thyroid carcinoma (PTC) including 147 patients (23.5%) with multifocal papillary thyroid microcarcinoma (PTMC) from a total of 2,536 patients with PTC who visited the Chang Gung Medical Center in Linkou, Taiwan, was performed. A comparison of the clinical features between 626 multifocal and 1,910 solitary PTC cases showed that patients in the multifocal PTC group were older and had a smaller mean tumor size, a more advanced tumor-node-metastasis (TNM) stage, and a higher percentage of nonremission status compared to patients in the solitary PTC group...
2017: International Journal of Endocrinology
https://www.readbyqxmd.com/read/28636673/evaluation-of-molecular-diagnostic-approaches-for-the-detection-of-braf-p-v600e-mutations-in-papillary-thyroid-cancer-clinical-implications
#10
Artur Kowalik, Aldona Kowalska, Agnieszka Walczyk, Renata Chodurska, Janusz Kopczyński, Magdalena Chrapek, Elżbieta Wypiórkiewicz, Małgorzata Chłopek, Liliana Pięciak, Danuta Gąsior-Perczak, Iwona Pałyga, Krzysztof Gruszczyński, Ewelina Nowak, Stanisław Góźdź
Differentiated papillary thyroid cancer (PTC) is the most common cancer of the endocrine system. PTC has a very good prognosis and a high 5 year survival rate; however, some patients are unresponsive to treatment, and their diagnosis eventually results in death. Recent efforts have focused on searching for prognostic and predictive factors that may enable treatment personalization and monitoring across the course of the disease. The presence of the BRAF mutation is considered to contribute to the risk of poor clinical course, according to American Thyroid Association (ATA) recommendations...
2017: PloS One
https://www.readbyqxmd.com/read/28635215/-retrospective-comparison-of-screening-criteria-for-active-surveillance-for-papillary-thyroid-microcarcinoma
#11
K Qian, T Q Sun, K Guo, X K Zheng, D S Li, W W Wei, Y Wu, Q H Ji, Z Y Wang
Objective: To investigate the rationality of management of active surveillance for papillary thyroid microcarcinoma (PTMC) and the main indications for active surveillance for PTMC. Methods: In this study, two criteria were used to evaluate patients with PTMC: low-risk PTMC conditions defined by Kuma hospital and Chinese Association of Thyroid Oncology (CATO) consensus on PTMC management of active surveillance. The patients had received surgical treatment. Clinicopathological characteristics and prognosis of the patients in different groups were compared...
June 7, 2017: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
https://www.readbyqxmd.com/read/28635214/-clinicopathological-characteristics-of-papillary-thyroid-microcarcinoma-and-risk-factors-for-central-lymph-node-metastasis
#12
Y L Wu, J M Sun, J J Zhang, Q X Cui, W H Zheng, X R Li
Objective: To analyze the clinicopathological characteristics of papillary thyroid microcarcinoma (PTMC) and risk factors for central lymph node metastasis(CLNM) in PTMC. Methods: The data of 900 patients with PTMC initially treated in our hospital from January 2004 to December 2015 were retrospectively analyzed. Chi-square test and Logistic regression analysis were performed to determine the risk factors for CLNM. Results: CLNM affected 162 (22.9%) of 707 patients treated with central lymph node dissection...
June 7, 2017: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
https://www.readbyqxmd.com/read/28629253/insights-into-the-management-of-papillary-microcarcinoma-of-the-thyroid
#13
Akira Miyauchi, Yasuhiro Ito, Hitomi Oda
BACKGROUND: Rapid increases in the incidence of thyroid carcinoma with stable mortality rates from thyroid carcinoma have been reported from many countries, and these increases are thought to be due mostly to the increased detection of small papillary thyroid carcinomas (PTCs), including papillary microcarcinomas (PMCs, i.e., PTCs ≤10 mm). Some researchers suggested small PTCs have been overdiagnosed and overtreated. In Japan, the active surveillance of patients with low-risk PMCs was initiated by Kuma Hospital (1993) and Tokyo's Cancer Institute Hospital (1995) based on the extremely higher incidences of both latent thyroid carcinomas in autopsy studies and small PTCs detected in mass screening studies using ultrasound examinations compared to the prevalence of clinical thyroid carcinoma...
June 19, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28621699/diagnostic-value-of-single-source-dual-energy-spectral-computed-tomography-for-papillary-thyroid-microcarcinomas
#14
Lin Li, Yong Wang, De-Hong Luo, Yan-Feng Zhao, Meng Lin, Wei Guo, Lei Hu, Chun-Wu Zhou, Xin-Ming Zhao
BACKGROUND: Ultrasound (US) and computed tomography (CT) are common diagnostic imaging methods for detecting and diagnosing papillary thyroid microcarcinoma (PTMC). However, single-source dual-energy spectral computed tomography (spectral CT) reduces beam hardening artefacts and optimizes contrast, which may add value in detecting PTMC. OBJECTIVE: To investigate values of applying single-source dual-energy spectral CT for diagnosing PTMCs, in comparison with high frequency ultrasound and conventional polychromatic images...
June 10, 2017: Journal of X-ray Science and Technology
https://www.readbyqxmd.com/read/28615984/papillary-thyroid-microcarcinoma-arising-within-a-mature-ovarian-teratoma-case-report-and-review-of-the-literature
#15
Maria M Pineyro, Jimena Pereda, Pamela Schou, Karina de Los Santos, Soledad de la Peña, Benedicta Caserta, Raul Pisabarro
Mature cystic teratoma is the most common kind of ovarian germ cell tumor. Malignant transformation is uncommon, with thyroid cancer rarely found. Papillary thyroid microcarcinoma has rarely been described as associated with ovarian teratomas. We report a case of a 34-year-old woman who presented with abdominal pain and an ovarian mass. After surgery, the patient was diagnosed with a follicular variant papillary thyroid microcarcinoma that arose within a mature cystic ovarian teratoma. Based on the small size of the primary lesion and patient preferences, no further treatment was performed...
2017: Clinical Medicine Insights. Endocrinology and Diabetes
https://www.readbyqxmd.com/read/28614984/tert-promoter-mutations-were-not-found-in-papillary-thyroid-microcarcinomas-that-showed-disease-progression-on-active-surveillance
#16
Tomonori Yabuta, Michiko Matsuse, Mitsuyoshi Hirokawa, Shunichi Yamashita, Norisato Mitsutake, Akira Miyauchi
No abstract text is available yet for this article.
July 11, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28611946/patients-with-multifocal-macroscopic-papillary-thyroid-carcinoma-have-a-low-risk-of-recurrence-at-early-follow-up-after-total-thyroidectomy-and-radioactive-iodine-treatment
#17
Amanda La Greca, Bin Xu, Ronald Ghossein, R Michael Tuttle, Mona M Sabra
BACKGROUND: Multifocal thyroid cancer involvement is a common presentation in papillary thyroid cancer. The risk of recurrence of intrathyroidal multifocal papillary microcarcinoma (<1 cm) is documented to be low. However, the risk of recurrence of multifocal macroscopic thyroid cancer is not known. Prior studies have suggested that both the number of foci and the presence of nodal involvement at diagnosis are important predictors of recurrence in multifocal papillary thyroid carcinoma (PTC)...
February 2017: European Thyroid Journal
https://www.readbyqxmd.com/read/28604340/increased-incidence-of-thyroid-cancer-in-navarra-spain-evolution-and-clinical-characteristics-1986-2010
#18
Jorge Rojo Álvaro, Begoña Bermejo Fraile, Edelmiro Menéndez Torre, Eva Ardanaz, Marcela Guevara, Emma Anda Apiñániz
INTRODUCTION: The latest published studies show an increased incidence of thyroid cancer worldwide. The aim of this study was to analyze the changes in the incidence of thyroid cancer in Navarra and its clinical presentation regarding sex, histological subtype and size over the last 25 years. METHODS: Thyroid cancer incidence rates were calculated on the basis of data from the Cancer Registry of Navarra during 1986-2010. Clinical data were obtained from the historical cohort of the Hospital Registry of Cancer of Navarra, which includes all the new cases of differentiated thyroid carcinoma diagnosed and treated in the public health network of this Community in that period...
June 2017: Endocrinología, diabetes y nutrición
https://www.readbyqxmd.com/read/28600731/lack-of-efficacy-of-radioiodine-remnant-ablation-for-papillary-thyroid-microcarcinoma-verification-using-inverse-probability-of-treatment-weighting
#19
Hyemi Kwon, Min Ji Jeon, Won Gu Kim, Suyeon Park, Mijin Kim, Tae Yong Kim, Minkyu Han, Dong Eun Song, Tae-Yon Sung, Jong Ho Yoon, Suck Joon Hong, Jin-Sook Ryu, Young Kee Shong, Won Bae Kim
BACKGROUND: Most of the increase in thyroid cancer in recent decades has been due to papillary thyroid microcarcinoma (PTMC). We evaluated the efficacy of radioiodine remnant ablation (RRA) in patients with PTMC. METHODS: This historical cohort study included 1932 PTMC patients without lateral cervical lymph node (LN) or distant metastasis who underwent total thyroidectomy (TT) during the median 8.3 years of follow-up. The clinical outcomes of patients with or without RRA were compared using weighted logistic regression models with the inverse probability of treatment weighting (IPTW) method and considering risk factors, including age, sex, primary tumor size, extrathyroidal extension, multifocality, and central cervical LN metastasis...
June 9, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28582521/the-prognostic-value-of-tumor-multifocality-in-clinical-outcomes-of-papillary-thyroid-cancer
#20
Fei Wang, Xiaolong Yu, Xiaopei Shen, Guangwu Zhu, Yueye Huang, Rengyun Liu, David Viola, Rossella Elisei, Efisio Puxeddu, Laura Fugazzola, Carla Colombo, Barbara Jarzab, Agnieszka Czarniecka, Alfred K Lam, Caterina Mian, Federica Vianello, Linwah Yip, Garcilaso Riesco-Eizaguirre, Pilar Santisteban, Christine J O'Neill, Mark S Sywak, Roderick Clifton-Bligh, Bela Bendlova, Vlasta Sýkorová, Yangang Wang, Shiguo Liu, Jiajun Zhao, Shihua Zhao, Mingzhao Xing
Context: Multifocality is often treated as a risk factor for papillary thyroid cancer (PTC), prompting aggressive treatments, but its prognostic value remains unestablished. Objective: To investigate the role of tumor multifocality in clinical outcomes of PTC. Methods: Multicenter study of the relationship between multifocality and clinical outcomes of PTC in 2638 patients (623 men and 2015 women) with median (interquartile range [IQR]) age of 46 (35-58) years and median (IQR) follow-up time of 58 (26-107) months at 11 medical centers in 6 countries...
June 5, 2017: Journal of Clinical Endocrinology and Metabolism
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