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papillary thyroid microcarcinoma

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https://www.readbyqxmd.com/read/29770856/risk-factors-associated-with-intrathyroid-extension-of-thyroid-microcarcinomas
#1
Nikola Slijepcevic, Vladan Zivaljevic, Aleksandar Diklic, Milan Jovanovic, Branislav Oluic, Ivan Paunovic
PURPOSE: The aims of this study were to investigate the rate of intrathyroid extension of papillary thyroid microcarcinoma (PTMC) in patients operated for benign thyroid disease and to identify independent risk factors associated with it. METHODS: A retrospective study of 301 patients operated for benign thyroid diseases (hyperthyroid diseases, multinodular goitre, Hashimoto thyroiditis and benign thyroid tumours) was performed at a high-volume endocrine surgery unit of a tertiary referral academic hospital, in a 5-year period...
May 17, 2018: Langenbeck's Archives of Surgery
https://www.readbyqxmd.com/read/29770318/is-advocacy-for-active-surveillance-over-definitive-intervention-in-papillary-thyroid-microcarcinoma-applicable-to-european-patients
#2
EDITORIAL
Gianlorenzo Dionigi
No abstract text is available yet for this article.
April 2018: Gland Surgery
https://www.readbyqxmd.com/read/29762261/a-retrospective-study-of-the-clinical-features-in-papillary-thyroid-microcarcinoma-depending-on-age
#3
Xuan Wang, Jian Tan, Wei Zheng, Ning Li
The aim of this study was to evaluate the clinical features and correlation of neck lymph node involvement of papillary thyroid microcarcinoma (PTMC) according to patients' age. We divided the patients into three groups according to age: young group (<45 years, n=83), middle group (45-54 years, n=80), and old group (≥55 years, n=53). The clinical features among the different groups were analyzed retrospectively. All of the 216 patients had received radioiodine ablation at least one time. Among these, 84 patients had central lymph node metastasis (CLNM), 11 patients had lateral lymph node metastasis (LLNM), and 26 patients had both CLNM and LLNM...
May 14, 2018: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/29760568/co-existence-of-braf-v600e-and-tert-promoter-mutations-in-papillary-thyroid-carcinoma-is-associated-with-tumor-aggressiveness-but-not-with-lymph-node-metastasis
#4
Haoyu Ren, Yifan Shen, Daixing Hu, Wei He, Jing Zhou, Yijia Cao, Yu Mao, Yi Dou, Wei Xiong, Qi Xiao, Yuhong Zhang, Xinliang Su
Background: Mutations of BRAF V600E and TERT promoters are associated with thyroid cancer development. This study further investigated association of these mutations with clinicopathological characteristics from patients with papillary thyroid carcinoma (PTC). Methods: Tumor tissues from 342 PTC patients were obtained for DNA extraction and polymerase chain reaction amplification to detect the BRAF V600E mutation using amplification-refractory mutation system-polymerase chain reaction...
2018: Cancer Management and Research
https://www.readbyqxmd.com/read/29760433/diagnostic-value-of-ultrasound-features-and-sex-of-fetuses-in-female-patients-with-papillary-thyroid-microcarcinoma
#5
Chun-Jie Hou, Ran Wei, Jing-Lan Tang, Qiao-Hong Hu, Hong-Feng He, Xiao-Ming Fan
Little work has been done on the prediction of papillary thyroid microcarcinoma in female patients who have given birth to children, which may be different from other people. We performed a retrospective review of female patients who underwent thyroidectomy, aiming at identifying special predictors of papillary thyroid microcarcinoma in female patients who have given birth to children. Univariate analysis was used to identify potential covariates for the prediction of papillary thyroid microcarcinoma. Multivariable logistic regression analysis was used to identify independent predictors and construct a regression model based on a training cohort (246 patients) and then the regression model was validated using an independent cohort (80 patients)...
May 14, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29740219/a-favorable-tumor-size-to-define-papillary-thyroid-microcarcinoma-an-analysis-of-1176-consecutive-cases
#6
Yanping Gong, Genpeng Li, Jianyong Lei, Jiaying You, Ke Jiang, Zhihui Li, Rixiang Gong, Jingqiang Zhu
Background: The optimal treatment strategy for papillary thyroid microcarcinoma (PTMC) has remained controversial. The purpose of this study was to provide a new reference value for PTMC to aid the selection of optimal management for minute lesions. Patients and methods: A pool of 1176 consecutive patients who met the inclusion criteria were ultimately enrolled in this study. The correlation of papillary thyroid carcinoma (PTC) tumor size and lymph node metastasis was analyzed...
2018: Cancer Management and Research
https://www.readbyqxmd.com/read/29694628/papillary-thyroid-microcarcinoma-characteristics-at-presentation-and-evaluation-of-clinical-and-histological-features-associated-with-a-worse-prognosis-in-a-latin-american-cohort
#7
José M Domínguez, Flavia Nilo, María T Martínez, José M Massardo, Sueli Muñoz, Tania Contreras, Rocío Carmona, Joaquín Jerez, Hernán González, Nicolás Droppelmann, Augusto León
Objective We aimed to describe the presentation of papillary microcarcinoma (PTMC) and identify the clinical and histological features associated with persistence/recurrence in a Latin American cohort. Subjects and methods Retrospective study of PTMC patients who underwent total thyroidectomy, with or without radioactive iodine (RAI), and who were followed for at least 2 years. Risk of recurrence was estimated with ATA 2009 and 2015 classifications, and risk of mortality with 7th and 8th AJCC/TNM systems. Clinical data obtained during follow-up were used to detect structural and biochemical persistence/recurrence...
February 2018: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29608416/trends-in-the-implementation-of-active-surveillance-for-low-risk-papillary-thyroid-microcarcinomas-at-kuma-hospital-gradual-increase-and-heterogeneity-in-the-acceptance-of-this-new-management-option
#8
Yasuhiro Ito, Akira Miyauchi, Takumi Kudo, Hitomi Oda, Masatoshi Yamamoto, Hisanori Sasai, Hiroo Masuoka, Mitsuhiro Fukushima, Takuya Higashiyama, Minoru Kihara, Akihiro Miya
BACKGROUND: Active surveillance (AS) of low-risk papillary thyroid microcarcinoma (PMC) was adopted as a management modality in both the Japanese guidelines in 2011 and the American Thyroid Association guidelines in 2015. AS was initiated at Kuma Hospital in 1993 but was not immediately accepted by all physicians. This study investigated the history of acceptance of AS at Kuma Hospital over time. The results should assist in the implementation of AS at other hospitals in Japan and other countries...
April 2, 2018: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29552130/interstitial-fibrosis-in-papillary-thyroid-microcarcinoma-and-its-association-with-biological-behavior
#9
Xun Liu, Shuai Zhang, Qinwei Gang, Shikai Shen, Jian Zhang, Yu Lun, Dongdong Xu, Zhiquan Duan, Shijie Xin
Previous studies have revealed that fibrosis may affect the biological behavior of tumors, however associated research on papillary thyroid microcarcinoma (PTMC) is rare. The aim of the present study was to explore the association between interstitial fibrosis (IF) and the biological behavior of PTMC. In the present study, a total of 511 consecutive cases of PTMC were evaluated for the presence of IF and its association with clinical parameters and pathologic biomarkers. IF was identified in 340 of the 511 consecutive cases and it was significantly associated with the age (P=0...
April 2018: Oncology Letters
https://www.readbyqxmd.com/read/29544469/thyroid-cancer-trends-in-incidence-mortality-and-clinical-pathological-patterns-in-zhejiang-province-southeast-china
#10
Lingbin Du, Youqing Wang, Xiaohui Sun, Huizhang Li, Xinwei Geng, Minghua Ge, Yimin Zhu
BACKGROUND: Thyroid cancer is the most common malignant disease of the endocrine system. Previous studies indicate a rapid increase in the incidence of thyroid cancer in recent decades, and this increase has aroused the great public concern. The aim of this study was to analyze the trends in incidence, mortality and clinical-pathological patterns of thyroid cancer in Zhejiang province. METHODS: Population-based incidence and mortality rates of thyroid cancer were collected from eight cancer registries in Zhejiang from 2000 to 2012...
March 15, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29543059/rising-incidence-of-thyroid-cancer-in-singapore-not-solely-due-to-micropapillary-subtype
#11
COMPARATIVE STUDY
J H Shulin, J Aizhen, S M Kuo, W B Tan, K Y Ngiam, R Parameswaran
Introduction The annual incidence of thyroid cancer is known to vary with geographic area, age and gender. The increasing incidence of thyroid cancer has been attributed to increase in detection of micropapillary subtype, among other factors. The aim of the study was to investigate time trends in the incidence of thyroid cancer in Singapore, an iodine-sufficient area. Materials and methods Data retrieved from the Singapore National Cancer Registry on all thyroid cancers that were diagnosed from 1974 to 2013 were reviewed...
April 2018: Annals of the Royal College of Surgeons of England
https://www.readbyqxmd.com/read/29538759/corrigendum-for-high-serum-tsh-level-is-associated-with-progression-of-papillary-thyroid-microcarcinoma-during-active-surveillance
#12
(no author information available yet)
No abstract text is available yet for this article.
May 1, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29517693/the-anteroposterior-diameter-of-nodules-in-the-risk-assessment-of-papillary-thyroid-microcarcinoma
#13
Kun Huang, Ningning Gao, Qixi Zhai, Donglin Bian, Difei Wang, Xuemei Wang
This study investigates the application of ultrasound, especially the anteroposterior diameter of nodules in the malignancy and metastasis risk assessment of papillary thyroid microcarcinoma through a retrospective analysis of 500 cases of thyroid nodule ultrasonography.We selected 500 patients with thyroid nodules (maximum nodule diameter ≤2.0 cm) that had been diagnosed clinically and graded TI-RADS 4c by ultrasonography and surgically treated. Among these, there were 258 cases of pathologically diagnosed papillary thyroid microcarcinoma, 72 cases of nodular goiter or adenoma, 137 cases of papillary thyroid carcinoma, 28 cases of acinar cell carcinoma, and 5 cases of undifferentiated carcinoma...
March 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29499654/patients-experiences-of-diagnosis-and-management-of-papillary-thyroid-microcarcinoma-a-qualitative-study
#14
Brooke Nickel, Juan P Brito, Ray Moynihan, Alexandra Barratt, Susan Jordan, Kirsten McCaffery
BACKGROUND: In recent years management practices in relation to low-risk papillary microcarcinoma (PMC) have been evolving with increased awareness of the potential overdiagnosis and overtreatment of PMCs, and guidelines recommendations for non-surgical management options such as active surveillance. This study aimed to develop an in-depth understanding of patients' experiences of the communication of their PMC diagnosis, their treatment preferences and decision making. METHODS: Semi-structured qualitative interviews with 25 patients diagnosed pre-operatively with PMC < 1 year since their diagnosis and treatment...
March 2, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29496990/the-role-of-diagnostic-131-i-spect-tc-in-patients-with-papillary-thyroid-microcarcinoma-in-long-term-follow-up
#15
Angela Spanu, Susanna Nuvoli, Ilaria Gelo, Luciana Mele, Bastiana Piras, Giuseppe Madeddu
Papillary thyroid microcarcinoma (PTMC) usually presents favourable prognosis, but it can also be aggressive with neck and distant metastases. We evaluated the diagnostic role of 131 I-single photon emission computed tomography/computed tomography (SPECT/CT) in detecting metastases in PTMC patients in long-term follow-up and whether the procedure may be included in the current diagnostic protocol. Methods: We retrospectively studied 351 consecutive PTMC patients already submitted to thyroidectomy and radioiodine therapy; 21/351 patients were at high risk (H), 94 at low risk (L) and 236 at very low risk (VL)...
March 1, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29488064/percutaneous-laser-ablation-of-unifocal-papillary-thyroid-microcarcinoma-utility-of-conventional-ultrasound-and-contrast-enhanced-ultrasound-in-assessing-local-therapeutic-response
#16
Lu Zhang, Wei Zhou, Weiwei Zhan, Yan Peng, Shan Jiang, Shangyan Xu
PURPOSE: To investigate the use of conventional ultrasound and contrast-enhanced ultrasound (CEUS) in assessing local therapeutic response of percutaneous laser ablation (PLA) for papillary thyroid microcarcinoma (PTMC). METHODS: Sixty-four patients with 64 PTMCs who were referred to our hospital from November 2013 to July 2016 were treated with PLA. The extent of ablation was assessed by CEUS at 10-20 min and 7 days after PLA. The size and volume of the ablation zone were evaluated on conventional ultrasound at 1 h, 1, 3, 6 and 12 months, and every half-year thereafter, and recurrences were also recorded...
February 27, 2018: World Journal of Surgery
https://www.readbyqxmd.com/read/29445865/risk-of-recurrence-in-a-homogeneously-managed-pt3-differentiated-thyroid-carcinoma-population
#17
Nathalie Chereau, Etienne Dauzier, Gaëlle Godiris-Petit, Séverine Noullet, Isabelle Brocheriou, Laurence Leenhardt, Camille Buffet, Fabrice Menegaux
BACKGROUND: International guidelines for the management of differentiated thyroid cancers are based on the 7th TNM classification: pT3 tumors are defined as differentiated thyroid cancers (DTCs) measuring more than 4 cm in their greatest dimension that are limited to the thyroid or any tumor with minimal extrathyroidal extension (ETE; sternothyroid muscle or perithyroid soft tissues). Differences in clinicohistological features and prognosis among patients with pT3 tumors remain controversial, and studies regarding pT3 subgroups are lacking...
February 14, 2018: Langenbeck's Archives of Surgery
https://www.readbyqxmd.com/read/29430119/a-rare-case-of-synchronous-papillary-microcarcinoma-and-metastatic-neuroendocrine-tumor-of-unknown-primary
#18
Shambo Guha Roy, Sarthak Tripathy, Girish Kumar Parida, Shipra Agarwal, Chandrasekhar Bal
Thyroid papillary microcarcinomas (PMCs) usually follow a very benign clinical course and are rarely metastatic. Any case of PMC presenting with distant metastases without any rising thyroglobulin level should be suspected to have any other primary apart from the thyroid and a meticulous clinical and diagnostic approach should be considered to identify the second primary. We hereby present a case of 52-year-old female treated as PMC with metastatic liver lesion, which was initially thought to be of thyroidal origin...
January 2018: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
https://www.readbyqxmd.com/read/29429179/-evaluation-of-central-lymph-node-dissection-for-papillary-thyroid-carcinoma-in-cn0-t1-t2
#19
S Y Zhao, Y H Ma, Z Yin, X X Zhan, R C Cheng, J Qian
Objective: To evaluate the application of the central lymph node dissection (CLND) for papillary thyroid carcinoma (PTC) in cN0 T1/T2. Methods: Retrospective analysis of 532 cases with PTC in cN0 T1/T2 who underwent CLND between October 2014 and September 2016 in the Department of Thyroid Surgery, the First Affiliated Hospital of the Kunming Medical University. The incidence of central lymph node (CLN) metastasis and risk factors were analyzed. Results: CLN metastasis rates: 41.2% (42/102) in males vs 34.9% (150/430) in females, P =0...
February 7, 2018: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
https://www.readbyqxmd.com/read/29428046/the-bethesda-classification-for-thyroid-fine-needle-aspiration-a-predictor-or-an-alarmist
#20
COMPARATIVE STUDY
John D Galbraith, Noah Swann, Brian Cox, Nobel LeTendre, James Recabaren
Thyroid malignancies comprise only 2 per cent of all cancers. Yet the incidence of thyroid cancers has been increasing faster than other malignancies, likely due to increased screening and surveillance of thyroid nodules. The Bethesda system represents the preferred method of evaluating thyroid nodules for malignancy using fine needle aspiration (FNA). Many thyroidectomies are performed for small, asymptomatic nodules found on ultrasound. These small papillary cancers (<0.5 cm) are termed microcarcinomas and represent a more indolent natural history causing some to name them "occult papillary tumors...
January 1, 2018: American Surgeon
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