Lei Fan, Xiangzhu Zhu, Shan Sun, Chang Yu, Xiang Huang, Reid Ness, Laura L Dugan, Lihua Shu, Douglas L Seidner, Harvey J Murff, Anthony A Fodor, M Andrea Azcarate-Peril, Martha J Shrubsole, Qi Dai
BACKGROUND & AIMS: Ketogenic medium-chain fatty acids (MCFAs) with profound health benefits are commonly found in dairy products, palm kernel oil and coconut oil. We hypothesize that magnesium (Mg) supplementation leads to enhanced gut microbial production of MCFAs and, in turn, increased circulating MCFAs levels. METHODS: We tested this hypothesis in the Personalized Prevention of Colorectal Cancer Trial (PPCCT) (NCT01105169), a double-blind 2 × 2 factorial randomized controlled trial enrolling 240 participants...
November 2022: Clinical Nutrition