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Filariasis , diagnosis

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https://www.readbyqxmd.com/read/29908250/immunochromatographic-test-for-rapid-serological-diagnosis-of-human-angiostrongyliasis
#1
Praphathip Eamsobhana, Anchalee Tungtrongchitr, Darawan Wanachiwanawin, Hoi-Sen Yong
OBJECTIVES: The serological diagnosis of human infection with Angiostrongylus cantonensis remains problematic because there are no commercially available validated tests. Most laboratories use domestically prepared tests such as the enzyme-linked immunosorbent assay (ELISA) or immunoblotting. Since laboratory facilities are not always available in endemic areas, we developed and assessed a rapid lateral flow immunochromatographic assay (AcQuickDx Test) to detect anti-A. cantonensis antibodies in human serum...
June 13, 2018: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/29900901/acute-scrotum-hansen-s-disease-versus-filariasis
#2
Deepak Vashisht, Bhavni Oberoi, Ruby Venugopal, Sukriti Baveja
Hansen's disease is caused by Mycobacterium leprae. The disease is known to involve the visceral organs including the testis apart from the skin and nerves in the lepromatous pole of leprosy due to widespread hematogenous dissemination of lepra bacilli. Furthermore, there can be testicular pain during the type 2 reaction in Hansen's disease. Filariasis is a disease caused by the parasitic nematode, Wuchereria bancrofti. This infection most commonly results in lymphedema and secondary vaginal hydrocele with an associated epididymo-orchitis...
April 2018: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/29895474/microfilaria-in-kidney-biopsy-a-report-of-two-cases
#3
Swasti Shubham, Arvind Ahuja, Minakshi Bhardwaj
Filariasis is traditionally diagnosed on finding microfilaria in peripheral blood smear and in cases of occult filariasis by immunological tests. Clinically, it presents with a wide range of symptoms and signs. We present two cases of filariasis presenting with renal symptoms warranting kidney biopsy. Histopathology of both revealed microfilaria in the glomerular capillary loop. First case was a 23-year-old male who presented with complaints of passage of milky urine. Second case was a 36-year-old female patient who presented with complaints of gross hematuria...
June 9, 2018: Journal of Infection and Public Health
https://www.readbyqxmd.com/read/29848402/cervical-lymphatic-filariasis-in-a-pediatric-patient-case-report-and-database-analysis-of-lymphatic-filariasis-in-the-united-states
#4
Jonathan C Simmonds, Michael K Mansour, Walid I Dagher
Lymphatic filariasis is a mosquito-borne parasitic infection caused by Wuchereria bancrofti and Brugia spp. Commonly seen in tropical developing countries, lymphatic filariasis occurs when adult worms deposit in and obstruct lymphatics. Although not endemic to the United States, a few cases of lymphatic filariasis caused by zoonotic Brugia spp. have been reported. Here we present a case of an 11-year-old female with no travel history who was seen in our clinic for a 1-year history of painless left cervical lymphadenopathy secondary to lymphatic filariasis...
May 29, 2018: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29773516/lymphoedema-management-to-prevent-acute-dermatolymphangioadenitis-in-podoconiosis-in-northern-ethiopia-golbet-a-pragmatic-randomised-controlled-trial
#5
Henok Negussie, Meseret Molla, Moses Ngari, James A Berkley, Esther Kivaya, Patricia Njuguna, Greg Fegan, Abreham Tamiru, Abebe Kelemework, Trudie Lang, Melanie J Newport, Andy McKay, Fikre Enquoselassie, Gail Davey
BACKGROUND: Podoconiosis (also known as endemic, non-filarial elephantiasis) affects about 4 million subsistence farmers in tropical Africa. Poor awareness of the condition and inadequate evidence for the efficacy of treatment mean that no government in an endemic country yet offers lymphoedema management for patients with podoconiosis. Among patients with filarial lymphoedema, trials suggest that limb care is effective in reducing the most disabling sequelae: episodes of acute dermatolymphangioadenitis...
May 14, 2018: Lancet Global Health
https://www.readbyqxmd.com/read/29709778/electrochemical-immunosensor-for-differential-diagnostic-of-wuchereria-bancrofti-using-a-synthetic-peptide
#6
Isis C Prado, Verônica G Mendes, André L A Souza, Rosa F Dutra, Salvatore G De-Simone
Lymphatic filariasis (LF) is a neglected tropical disease transmitted by mosquitoes and the second cause of permanent disability leading to a significant morbidity and mortality rate. Previously, we have identified epitopes of the filarial abundant larval transcript-2 (ALT-2) protein using a microarray mapping. In this study, one of the epitopes (Wb/ALT2-A5) was used to construct an electrochemical immunosensor. Electrochemical technique of cyclic voltammetry was performed for detecting the signal generated by the interaction between the (Wb/ALT2-A5) peptide and circulating antibodies of serum human samples...
April 22, 2018: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29661231/surveillance-for-lymphatic-filariasis-after-stopping-mass-drug-administration-in-endemic-districts-of-togo-2010-2015
#7
Monique Ameyo Dorkenoo, Rachel Bronzan, Degninou Yehadji, Mawèke Tchalim, Kossi Yakpa, Santrao Etassoli, Poukpessi Adjeloh, Issaka Maman, Yao Sodahlon
BACKGROUND: Togo is a country previously endemic for lymphatic filariasis (LF). In 2010, following nine years of mass drug administration (MDA) for LF, the country established a post-treatment surveillance (PTS) system. We present here the results of these PTS activities, carried out from 2010 to 2015, as well as the findings of follow-up investigations in 2016 to confirm the absence of infection in previously infected individuals. METHODS: The routine surveillance established in 2010 consisted of a network of 47 laboratories, which searched for Wuchereria bancrofti microfilaria on nocturnal blood smears collected for malaria diagnosis and an additional network of 20 peripheral health facilities, which collected dried blood spots and tested them for Og4C3 antigen...
April 16, 2018: Parasites & Vectors
https://www.readbyqxmd.com/read/29630086/isolated-epitrochlear-filarial-lymphadenopathy-cytomorphological-diagnosis-of-an-unusual-presentation
#8
Priya Sahu, Prajwala Gupta, Minakshi Bhardwaj, C K Durga
Filariasis is a major public health problem in tropical countries like India. Despite the large number of people at risk, detection of eggs with or without larva (microfilaria) on fine-needle aspiration cytology is very unusual, especially in an uncommon site or incidentally detected in clinically unsuspected cases of filariasis with the absence of microfilariae in the peripheral blood. A 19-year-old male presented with swelling over medial aspect of left arm (just above the elbow), with no other specific signs and symptoms...
April 9, 2018: Türk Patoloji Dergisi
https://www.readbyqxmd.com/read/29590236/evaluation-of-the-recombinant-antigens-wb14-and-wbt-for-the-capture-antibody-diagnosis-of-lymphatic-filariasis
#9
COMPARATIVE STUDY
André Filipe Pastor, Abraham Rocha, Klécia de Melo Cassemiro, Marli Tenório, Paula Melo, Maria Rosângela Grilis, Maressa Rhuama, Antonio Mauro Rezende, Osvaldo Pompilio de Melo Neto, Ernesto Marques, Rafael Dhalia
BACKGROUND: Lymphatic filariasis (LF) is a parasitic disease caused mainly by the Wuchereria bancrofti worm and that affects up to 120 million people worldwide. LF is the second cause of chronic global deformity, responsible for 15 million people with lymphedema (elephantiasis) and 25 million men with scrotal hydrocele. Its diagnosis is still associated with numerous difficulties, such as the sample collection periods (microfilaria nocturnal periodicity) and limited diagnostic kits. OBJECTIVES: The aim of this work was to evaluate two recombinant antigens (Wb14 and WbT) as part of an enzyme-linked immunosorbent assay (ELISA) based antibody capture tests for LF...
March 26, 2018: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/29289559/geographical-distribution-and-species-identification-of-human-filariasis-and-onchocerciasis-in-bioko-island-equatorial-guinea
#10
Thuy-Huong Ta, Laura Moya, Justino Nguema, Pilar Aparicio, María Miguel-Oteo, Gema Cenzual, Isabel Canorea, Marta Lanza, Agustín Benito, James Lee Crainey, José Miguel Rubio
Human filariae are vector-borne parasites and the causative agents of various diseases, including human onchocerciasis and lymphatic filariasis. Onchocerciasis causes a spectrum of cutaneous and ophthalmologic manifestations (including blindness) and has long been a major public health problem in Bioko Island (Equatorial Guinea). Bioko Island has been included in the WHO's Onchocerciasis Control Program since 1987. In Bioko Island, the specificity and sensitivity of clinical Onchocerca volvulus diagnosis is key...
April 2018: Acta Tropica
https://www.readbyqxmd.com/read/29259652/cytomorphological-spectrum-of-epididymal-nodules-an-institution-s-experience
#11
Jyotsna Naresh Bharti, Biswajit Dey, Jenna Bhattacharya, Shyama Jain
Background: Epididymal lesions are uncommon in clinical practice. Few case series has been described in the literature documenting the role of cytology in the evaluation of epididymal nodules. This study was undertaken to analyze the cytomorphology of epididymal nodules and to evaluate role of fine-needle aspiration biopsy (FNAB) in early definitive diagnosis of epididymal nodules. Materials and Methods: A total of seventy cases of epididymal nodules were aspirated over a period of 6 years in the Department of Pathology...
2017: CytoJournal
https://www.readbyqxmd.com/read/29184008/bilateral-breast-filariasis-mimicking-inflammatory-breast-carcinoma
#12
Simi Das, Hira Lal, Mousam Dey, Namita Mohindra
Breast is an uncommon site to be affected in filariasis. However, such cases may be encountered in endemic areas. Here, we report a case of filariasis of breast in a 55-year-old woman who was clinically mistaken for inflammatory carcinoma of the breast. Sonomammography revealed classic signs pointing towards the diagnosis of filariasis of breast, which was confirmed with microscopic examination of fine-needle aspirate. Thus, imaging played a pivotal role in correctly diagnosing and further altering the line of management...
November 28, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28978592/filiarial-chyluria-with-nephrotic-range-proteinuria-and-associated-hypoalbuminaemia-and-hypogammaglobulinaemia-secondary-to-bilateral-lymphorenal-fistulae
#13
Joseph Faraj, Julian Mander, John R Burnett, David Prentice
A 55-year-old man of Indian descent, presented to the emergency department with a 2-year history of passing 'milky' white urine, associated with dysuria, urinary retention, bilateral flank pain and 15 kg weight loss. He had migrated to Australia from India at the age of 16, with no overseas travel since, and denied having any fevers, rigours or chills. He was found to have chyluria and nephrotic-range proteinuria with marked hypoalbuminaemia and hypogammaglobulinaemia. Due to his ethnic origin and by diagnostic exclusion, a presumptive diagnosis of filariasis was made...
October 4, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28833498/generation-and-selection-of-na%C3%A3-ve-fab-library-for-parasitic-antigen-anti-bmsxp-antibodies-for-lymphatic-filariasis
#14
Noorsharmimi Omar, Nurul Hamizah Hamidon, Muhammad Hafiznur Yunus, Rahmah Noordin, Yee Siew Choong, Theam Soon Lim
Phage display has been applied successfully as a tool for the generation of monoclonal antibodies (mAbs). Naive antibody libraries are unique as they are able to overcome several limitations associated with conventional mAb generation methods like the hybridoma technology. Here, we performed an in vitro selection and generation of Fab antibodies against Brugia malayi SXP protein (BmSXP), a recombinant antigen for the detection of lymphatic filariasis. We developed a naïve multi ethnic Fab antibody library with an estimated diversity of 2...
August 21, 2017: Biotechnology and Applied Biochemistry
https://www.readbyqxmd.com/read/28819487/an-evaluation-of-wb123-antibody-elisa-in-individuals-treated-with-ivermectin-and-albendazole-and-implementation-challenges-in-africa
#15
Dziedzom Komi de Souza, Irene Offei Owusu, Joseph Otchere, Michelle Adimazoya, Kwadwo Frempong, Collins Stephen Ahorlu, Daniel Adjei Boakye, Michael David Wilson
The development of antibody testing for the diagnosis of lymphatic filariasis (LF) is intended to enhance the monitoring and evaluation activities of the Global Program for the Elimination of LF. This is due to the fact that antibody tests are expected to be the most sensitive at detecting exposure to LF compared to antigen that takes longer to develop. To this end a new antibody-based enzyme linked immunosorbent assay (ELISA) to Wuchereria bancrofti antigen Wb123 has been developed and further designed into a point of care rapid diagnostic test, under evaluation...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28818649/sequence-analysis-of-mtdna-coi-barcode-region-revealed-three-haplotypes-within-culex-pipiens-assemblage
#16
Mona Koosha, Mohammad Ali Oshaghi, Mohammad Mehdi Sedaghat, Hassan Vatandoost, Shahyad Azari-Hamidian, Mohammad Reza Abai, Ahmad Ali Hanafi-Bojd, Fatemeh Mohtarami
Members of the Culex (Culex) pipiens assemblage are known vectors of deadly encephalitides, periodic filariasis, and West Nile virus throughout the world. However, members of this assemblage are morphologically indistinguishable or hard to distinguish and play distinct roles in transmission of the diseases. The current study aimed to provide further evidence on utility of the two most popular nuclear (ITS2-rDNA) and mitochondrial (COI barcode region) genetic markers to identify members of the assemblage. Culex pipiens assemblage specimens from different climate zones of Iran were collected and identified to species level based on morphological characteristics...
October 2017: Experimental Parasitology
https://www.readbyqxmd.com/read/28722622/side-benefits-of-mass-drug-administration-for-lymphatic-filariasis-on-strongyloides-stercoralis-prevalence-on-pemba-island-tanzania
#17
Beatrice Barda, Marco Albonico, Dora Buonfrate, Shaali M Ame, Said Ali, Benjamin Speich, Jennifer Keiser
Strongyloides stercoralis, although endemic in many countries, is not included in helminth control programs. Few data are available on the prevalence and morbidity linked to this infection. We compared data from two studies conducted in 1998 and 2013 on Pemba Island, Tanzania, involving 525 and 509 schoolchildren, respectively. In 1998, the diagnostic method used was Harada Mori, whereas in 2013 diagnosis was made by both Koga agar plate and Baermann methods. The prevalence registered was 41% in 1998 and 7% in 2013...
September 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28507911/filariasis-orchitis-differential-for-acute-scrotum-pathology
#18
Karmon M Janssen, Cornelia J Willis, Mark Anderson, Mary S Gelnett, Emily L Wickersham, Timothy C Brand
Granulomatous Orchitis secondary to lymphatic filiarisis is a rare diagnosis within the United States. We report a case of a 22yo Male from Sri Lanka, with a new onset scrotal swelling and palpable right testicular mass. Ultrasound identified a 1 cm right testicular mass with signs of tunica albuginea invasion. A right inguinal radical orchiectomy was performed and pathology showed Filarial orchitis. This report describes the detailed history, physical exam, and diagnostic workup and treatment options for a rare entity for acute scrotal pathology...
July 2017: Urology Case Reports
https://www.readbyqxmd.com/read/28279364/-chyluria-with-nephrotic-syndrome-like-presentation-diagnostic-and-therapeutic-approach
#19
S Bally, A Demey, L Arrivé, C Rullier
Chyluria implies an abnormal communication between the lymphatic system and the urinary tract. It is more frequent in endemic areas of lymphatic filariasis, which constitutes the main cause. Chyluria may mimic a nephrotic syndrome. Diagnosis of chyluria is based on urinary cytological and biocheminal analysis. Localization of the fistula needs medical imaging: cystoscopy, retrograde pyelography, lymphoscintigraphy and more recently magnetic resonance lymphography. Due to frequent spontaneous remissions, traitement can require only dietary measures...
December 2016: Progrès en Urologie
https://www.readbyqxmd.com/read/28199317/colorimetric-tests-for-diagnosis-of-filarial-infection-and-vector-surveillance-using-non-instrumented-nucleic-acid-loop-mediated-isothermal-amplification-nina-lamp
#20
Catherine B Poole, Zhiru Li, Andy Alhassan, Dylan Guelig, Steven Diesburg, Nathan A Tanner, Yinhua Zhang, Thomas C Evans, Paul LaBarre, Samuel Wanji, Robert A Burton, Clotilde K S Carlow
Accurate detection of filarial parasites in humans is essential for the implementation and evaluation of mass drug administration programs to control onchocerciasis and lymphatic filariasis. Determining the infection levels in vector populations is also important for assessing transmission, deciding when drug treatments may be terminated and for monitoring recrudescence. Immunological methods to detect infection in humans are available, however, cross-reactivity issues have been reported. Nucleic acid-based molecular assays offer high levels of specificity and sensitivity, and can be used to detect infection in both humans and vectors...
2017: PloS One
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