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Dermal Implants

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https://www.readbyqxmd.com/read/28812172/delayed-post-mastectomy-breast-reconstructions-with-allogeneic-acellular-dermal-matrix-prepared-by-a-new-decellularizationmethod
#1
Martin Bohac, Ivan Varga, Stefan Polak, Jana Dragunova, Jozef Fedeles, Jan Koller
Acellular dermal matrix (ADM) is a tissue graft of allogeneic origin from post-mortem tissue donors prepared by an innovative decellularization process. The newly developed non-toxic and low cost decellularization process of cadaver origin dermis included ADM in breast reconstruction procedures proved to help coverage of the lower-pole of breast expanders or implants. As the results have shown, it did help to eliminate autologous dermis donor site morbidity along with shortening the operation time by avoiding elevation of additional muscle or fascia during the operation...
August 16, 2017: Cell and Tissue Banking
https://www.readbyqxmd.com/read/28810287/seeding-density-is-a-crucial-determinant-for-the-in-vivo-vascularisation-capacity-of-adipose-tissue-derived-microvascular-fragments
#2
T Später, C Körbel, F S Frueh, R M Nickels, M D Menger, M W Laschke
Adipose tissue-derived microvascular fragments (ad-MVF) represent effective vascularisation units for the seeding of dermal substitutes. However, particularly in case of extensive skin defects, the required amounts of donor fat tissue for the harvesting of ad-MVF may not always be available. Therefore, we herein determined the lowest ad-MVF density needed to induce a sufficient vascularisation and incorporation of seeded implants. Collagen-glycosaminoglycan matrices (Integra®; diameter: 4 mm) were seeded with 15,000 (HD), 10,000 (MD) and 5,000 (LD) ad-MVF and implanted into full-thickness skin defects within mouse dorsal skinfold chambers, to analyse their in vivo vascularisation and incorporation...
August 15, 2017: European Cells & Materials
https://www.readbyqxmd.com/read/28806288/acellular-dermal-matrix-in-immediate-expander-implant-breast-reconstruction-a-multicenter-assessment-of-risks-and-benefits
#3
Michael Sorkin, Ji Qi, Hyungjin M Kim, Jennifer B Hamill, Jeffrey H Kozlow, Andrea L Pusic, Edwin G Wilkins
INTRODUCTION: Acellular dermal matrix (ADM) has gained widespread acceptance in immediate expander/implant reconstruction due to perceived benefits, including improved expansion dynamics and superior aesthetic results. Although previous investigators have evaluated its risks, few studies have assessed the impact of ADM on other outcomes, including patient-reported measures. METHODS: The Mastectomy Reconstruction Outcomes Consortium (MROC) Study used a prospective cohort design to evaluate patients undergoing post-mastectomy reconstruction from 10 centers and 58 participating surgeons between 2012 and 2015...
August 3, 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28799557/the-application-of-an-acellular-dermal-allograft-alloderm-for-patients-with-insufficient-conjunctiva-during-evisceration-and-implantation-surgery
#4
S J Park, Y Kim, S Y Jang
PurposeTo describe the use of an acellular dermal allograft (AlloDerm) for patients with insufficient conjunctiva during evisceration and implantation surgery.Patients and methodsThe medical records of six patients with insufficient conjunctiva during evisceration surgery were reviewed. It was not possible to close the Tenon's capsule and conjunctiva without wound tension in these patients, so AlloDerm was placed over the sclera, and the edges were sutured with adjacent conjunctiva without tension. The size of the bare AlloDerm graft was measured in all patients...
August 11, 2017: Eye
https://www.readbyqxmd.com/read/28780465/investigating-the-race-for-the-surface-and-skin-integration-in-clinically-retrieved-abutments-with-two-photon-microscopy
#5
D Kapsokalyvas, M van Hoof, S Wigren, T Chimhanda, H J Kuijpers, F C S Ramaekers, R J Stokroos, M A M J van Zandvoort
Bone conduction hearing implants can rehabilitate some types of hearing loss. A hydroxyapatite (HA)-coated skin-penetrating abutment was developed to allow for soft tissue preservation and increased skin-abutment adherence. Inflammation is thought to relate to bacterial infection of pockets around the abutment. Upon integration, the host's ability to cover the abutment surface ("race for the surface"), and thus control and prevent competitive bacteria from colonizing it, is improved. However, the attachment mechanisms behind it are not clear...
July 27, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28780249/dermal-fat-graft-for-anophthalmic-socket-in-children-enucleated-for-retinoblastoma
#6
V Bosch-Canto, C Cruz, J C Ordaz-Favila
Retinoblastoma is the most frequent intraocular tumour in childhood. The definitive treatment is enucleation. The management of the anophthalmic socket consists in the use of a plastic implant. The problem is that they are expensive and they usually extrude. The use of dermal-fat grafts minimises the hemi-facial hypoplasia. They usually grow with the face, and help to expand the orbital bones, thus avoiding the psychological and physical consequences. OBJECTIVE: To determine if there is hemi-facial hypoplasia, using MRI images after the use of a dermal-fat implant in patients enucleated for RB...
August 2, 2017: Archivos de la Sociedad Española de Oftalmología
https://www.readbyqxmd.com/read/28765784/tissue-expansion-for-breast-reconstruction-methods-and-techniques
#7
REVIEW
Nicolò Bertozzi, Marianna Pesce, PierLuigi Santi, Edoardo Raposio
OBJECTIVE: In this work, the authors review recent data on the different methods and techniques of TE/implant-based reconstruction to determine the complication profiles and the advantages and disadvantages of the different techniques. This information will be valuable for surgeons performing breast reconstructions. MATERIALS AND METHODS: A thorough literature review was conducted by the authors concerning the current strategy of tissue expander (TE)/implant-based breast reconstruction following breast cancer surgery...
September 2017: Annals of Medicine and Surgery
https://www.readbyqxmd.com/read/28752668/comparison-of-two-decellularized-dermal-equivalents
#8
Shiuhyang Kuo, Hyungjin Myra Kim, Zhifa Wang, Eve L Bingham, Atsuko Miyazawa, Cynthia L Marcelo, Stephen E Feinberg
Immunologically inert allogeneic acellular dermal scaffolds provide a matrix with molecular architecture close to native tissues, which synthetic scaffolds cannot. Not all nature-derived scaffolds possess the same biological and physical properties. The different properties of scaffolds supporting cellular growth used for manufacturing tissue engineered grafts could lead to different implantation results. The scaffold properties should be carefully considered in order to meet the expected outcomes of tissue engineered grafts...
July 28, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/28740788/acellular-dermal-matrix-versus-inferior-deepithelialized-flap-breast-reconstruction-equivalent-outcomes-with-increased-cost
#9
Heidi H Hon, Ronnie N Mubang, Brian D Wernick, Samuel F Freedman, Jill C Stoltzfus, Lino F Miele, Stanislaw P Stawicki, W Michael Morrissey
BACKGROUND: Approximately 250,000 new cases of breast cancer are diagnosed yearly in the U.S. resulting in more postmastectomy breast reconstructions (PMBRs). The acellular dermal matrix (ADM) expander-implant method became popular in the mid-2000s, but newer techniques such as the inferior deepithelialized flap (IDF) has more recently been described. We hypothesize that ADMs and IDFs provide comparable aesthetic outcomes, with no difference in complication rates and operative characteristics...
June 2017: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/28736191/clinical-histological-and-ultrasound-follow-up-of-breast-reconstruction-with-one-stage-muscle-sparing-wrap-technique-a-single-center-experience
#10
Maria Giuseppina Onesti, Michele Maruccia, Giuseppe Di Taranto, Antonio Albano, Giuseppe Soda, Laura Ballesio, Nicolò Scuderi
BACKGROUND: Prepectoral implant placement and complete coverage with porcine acellular matrix after mastectomy is a new concept in breast surgery presented in few cases in the literature. This paper aimed to present our single-center experience in one-stage breast reconstruction muscle-sparing "wrap" technique by evaluating clinical and aesthetic outcomes, ultrasound and histological examination, and patient quality of life. METHODS: From January 2014 to January 2017, 52 patients (40 unilateral, 12 bilateral) underwent one-stage muscle-sparing breast reconstructions with Braxon(®) acellular dermal matrix and implant...
June 29, 2017: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/28727237/pre-hydrated-sterile-acellular-dermal-matrix-allograft-in-breast-reconstruction-review-of-a-single-unit-s-experience
#11
Justin James, Brigid Corrigan, Christobel Saunders
BACKGROUND: The acellular dermal matrix (Flex HD) (FHD) became available for use in Western Australia in 2014 to aid prosthetic breast reconstruction and this descriptive study aims to review and discuss a single institution's experience since its introduction. METHODS: By retrospective case note, review data were collected for all patients who underwent prosthetic breast reconstruction with the aid of FHD between January 2014 and August 2015 in our institution...
July 20, 2017: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/28710505/application-of-human-acellular-breast-dermal-matrix-abdm-in-implant-based-breast-reconstruction-an-experimental-study
#12
Nahid Nafisi, Mohammad Esmaeil Akbari, Fatemeh Mahjoub, Mohammad Javad Mohseni, Shabnam Sabetkish, Reza Khorramirouz, Mona Tehrani, Abdol-Mohammad Kajbafzadeh
BACKGROUND: The use of acellular dermal matrices (ABDM) has become more common for breast reconstruction to improve postoperative outcomes. We evaluated the efficacy of breast reconstruction by the application of human ABDM in a sheep model. METHODS: The sheep in group I (GI) (N = 4) underwent the following procedures on the right side: (1) breast reconstruction using human ABDM after total mastectomy, (2) human ABDM under the skin, near the breast area and on the left side, (3) fat injection and human ABDM after partial mastectomy, and (4) replacement of ABDM in the abdominal wall far from the breast...
July 14, 2017: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/28709788/making-sense-of-metal-allergy-and-hypersensitivity-to-metallic-implants-in-relation-to-hand-surgery
#13
REVIEW
Thomas J Christensen, Shefali A Samant, Alexander Y Shin
All metals implanted into a biological system undergo some degree of corrosion depending upon its composition. The electrochemical process of corrosion produces free metal ions, which may activate the host's immune system through a variety of mechanisms. Whereas dermal metal hypersensitivity is common, affecting 10% to 15% of the population, the immune reaction from implanted metals is much less common (< 0.1%), but has been associated with metal allergy and hypersensitivity producing a multitude of patient symptoms...
July 11, 2017: Journal of Hand Surgery
https://www.readbyqxmd.com/read/28706796/arthroscopic-removal-of-a-loose-polyethylene-glenoid-component-with-bone-grafting-and-patch-augmentation-for-glenoid-osseous-defect
#14
Jeffrey T Abildgaard, Jared C Bentley, Richard J Hawkins, John M Tokish
Glenoid component loosening is a common cause of failed total shoulder arthroplasty. Many different treatment options exist for the management of a symptomatic loose polyethylene glenoid component, ranging from component removal to revision arthroplasty. Arthroscopic removal and conversion to hemiarthroplasty provides a minimally invasive management option that avoids takedown of the subscapularis and allows for humeral prosthesis retention. Frequently, however, osteolysis is encountered concomitantly leading to cavitary glenoid bone deficits at the time of glenoid implant removal, limiting both immediate and future treatment options...
June 2017: Arthroscopy Techniques
https://www.readbyqxmd.com/read/28692604/determining-the-differential-effects-of-stretch-and-growth-in-tissue-expanded-skin-combining-isogeometric-analysis-and-continuum-mechanics-in-a-porcine-model
#15
Chad A Purnell, Michael S Gart, Adrián Buganza-Tepole, Joanna P Tomaszewski, Jolanta M Topczewska, Ellen Kuhl, Arun K Gosain
BACKGROUND: The relative effects of skin growth and stretch during tissue expansion have not been studied. The authors use novel analytic techniques that allow calculation of these factors at any point of a skin patch. OBJECTIVE: The authors sought to determine how stretch and growth change with different expansion rates and to correlate these values with histologic and cellular changes in skin. MATERIALS AND METHODS: Two minipigs were implanted with a total of 5 tissue expanders under tattooed skin grids...
July 6, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28689433/experimental-and-early-investigational-drugs-for-androgenetic-alopecia
#16
REVIEW
Hongwei Guo, Wendi Victor Gao, Hiromi Endo, Kevin John McElwee
Treatments for androgenetic alopecia constitute a multi-billion-dollar industry, however, currently available therapeutic options have variable efficacy. Consequently, in recent years small biotechnology companies and academic research laboratories have begun to investigate new or improved treatment methods. Research and development approaches include improved formulations and modes of application for current drugs, new drug development, development of cell-based treatments, and medical devices for modulation of hair growth...
August 2017: Expert Opinion on Investigational Drugs
https://www.readbyqxmd.com/read/28684336/coculture-of-mesenchymal-stem-cells-and-endothelial-cells-enhances-host-tissue-integration-and-epidermis-maturation-through-akt-activation-in-gelatin-methacryloyl-hydrogel-based-skin-model
#17
Xiaofei Zhang, Jun Li, Pengxiang Ye, Guifang Gao, Karen Hubbell, Xiaofeng Cui
A major challenge for clinical use of skin substitutes is insufficient host tissue integration leading to loosening and partial necrosis of the implant. In this present study, a three-dimensional (3D) coculture system constructed using human umbilical cord mesenchymal stem cells (uc-MSCs) and umbilical vein endothelial cells (HUVECs) encapsulated in gelatin methacryloyl (GelMA) hydrogels was evaluated to determine the outcomes of cell-cell interactions in vitro and in vivo. The results revealed that GelMA hydrogels displayed minor cytotoxicity on both cell types...
September 1, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28669866/procedures-and-applications-of-long-term-intravital-microscopy
#18
REVIEW
Chloé Prunier, Na Chen, Laila Ritsma, Nienke Vrisekoop
Intravital microscopy (IVM) is increasingly used in biomedical research to study dynamic processes at cellular and subcellular resolution in their natural environment. Long-term IVM especially can be applied to visualize migration and proliferation over days to months within the same animal without recurrent surgeries. Skin can be repetitively imaged without surgery. To intermittently visualize cells in other organs, such as liver, mammary gland and brain, different imaging windows including the abdominal imaging window (AIW), dermal imaging window (DIW) and cranial imaging window (CIW) have been developed...
June 29, 2017: Methods: a Companion to Methods in Enzymology
https://www.readbyqxmd.com/read/28658716/sustained-secretion-of-anti-tnf-alpha-monoclonal-antibody-from-ex-vivo-genetically-engineered-dermal-tissue-demonstrates-therapeutic-activity-in-mouse-model-of-rheumatoid-arthritis
#19
Inbal Zafir-Lavie, Reem Miari, Shay Sherbo, Simi Krispel, Osnat Tal, Atar Liran, Tamar Shatil, Felix Badinter, Haim Goltsman, Nir Shapir, Itai Benhar, Garry A Neil, Amos Panet
BACKGROUND: Rheumatoid arthritis is a symmetric inflammatory polyarthritis associated with high concentrations of pro-inflammatory cytokines including TNF-α. Adalimumab is a monoclonal antibody (mAb) that binds TNF-α, and is widely used to treat rheumatoid arthritis. Despite its proven clinical efficacy, adalimumab and other therapeutic mAbs have disadvantages including the requirement for repeated bolus injections and the appearance of treatment limiting anti-drug antibodies. To address these issues, we have developed an innovative ex-vivo gene therapy approach, Transduced Autologous Restorative Gene Therapy (TARGT), to produce and secrete adalimumab for the treatment of RA...
June 28, 2017: Journal of Gene Medicine
https://www.readbyqxmd.com/read/28655891/a-gelatin-sulfonated-silk-composite-scaffold-based-on-3d-printing-technology-enhances-skin-regeneration-by-stimulating-epidermal-growth-and-dermal-neovascularization
#20
Si Xiong, Xianzhu Zhang, Ping Lu, Yan Wu, Quan Wang, Heng Sun, Boon Chin Heng, Varitsara Bunpetch, Shufang Zhang, Hongwei Ouyang
One of the key problems hindering skin repair is the deficiency of dermal vascularization and difficulty of epidermis regeneration, which makes it challenging to fabricate scaffolds that can biologically fulfill the requirements for skin regeneration. To overcome this problem, three-dimensional printing was used to fabricate a gelatin-sulfonated silk composite scaffold that was incorporated with basic fibroblast growth factor 2 (FGF-2) through binding with a sulfonic acid group (SO3) (3DG-SF-SO3-FGF). The efficacy and mechanism by which the 3DG-SF-SO3-FGF scaffolds promote skin regeneration were investigated both within in vitro cell culture and in vivo with a full-thickness skin defect model...
June 27, 2017: Scientific Reports
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