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Dermal Implants

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https://www.readbyqxmd.com/read/28939521/afm-analysis-of-collagen-fibrils-in-expanded-scalp-tissue-after-anisotropic-tissue-expansion
#1
Jazli Aziz, Muhamad Fadhil Ahmad, Mohammad Tariqur Rahman, Noor Azlin Yahya, Jan Czernuszka, Zamri Radzi
Successful use of tissue expanders depends on the quality of expanded tissue. This study evaluates the impact of anisotropic self-inflating tissue expander (SITE) on the biomechanics of skin. Two different SITE were implanted subcutaneously on sheep scalps; SITE that requires 30days for maximum expansion (Group A; n=5), and SITE that requires 21days for maximum expansion (Group B; n=5). Control animals (n=5) were maintained without SITE implantation. Young's Modulus, D-periodicity, overlap and gap region length, diameter, and height difference between overlap and gap regions on collagen fibrils were analyzed using atomic force microscopy...
September 19, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28935005/sequelae-of-occult-aggression-disqualifying-young-socially-housed-female-new-zealand-white-rabbits-oryctolagus-cuniculus-from-participation-in-dermal-toxicology-studies
#2
Jeffrey D Wyatt, Diane M Moorman-White, Donnalee Ventura, Brett W Schneider, Thomas W Bittner
International animal welfare organizations and federal, regional, and institutional oversight bodies encourage social housing of gregarious species, such as New Zealand white rabbits (Oryctolagus cuniculus), to promote animal wellbeing in research, teaching, testing and farming settings. At our institution, 2 groups of female New Zealand white rabbits (approximate age, 11 wk; mean weight, 2.35 kg), compatibly paired at the vendor for 5 wk, were paired in caging or group-housed in a floor pen. The rabbits appeared compatible, demonstrating primarily affiliative behaviors throughout 6 wk of daily observations...
October 1, 2017: Comparative Medicine
https://www.readbyqxmd.com/read/28932941/single-center-ventral-hernia-repair-with-porcine-dermis-collagen-implant
#3
M Boules, A T Strong, R Corcelles, I N Haskins, R Ilie, C Wathen, D Froylich, G Sharma, J Rodriguez, S Rosenblatt, K El-Hayek, M Kroh
INTRODUCTION: This study aims to evaluate the outcomes and utilization of porcine acellular dermal collagen implant (PADCI) during VHR at a large tertiary referral center. METHODS: Records of 5485 patients who underwent VIHR from June 1995 to August 2014 were retrospectively reviewed to identify patients >18 years of age who had VIHR with PADCI reinforcement. Use of multiple mesh reinforcement products, inguinal hernias, and hiatal hernias were exclusion criteria...
September 20, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28917935/trends-in-post-mastectomy-breast-reconstruction-types-at-a-breast-cancer-tertiary-referral-centre-before-and-after-introduction-of-acellular-dermal-matrices
#4
Hadyn K N Kankam, George J M Hourston, Laura J Fopp, John R Benson, Sarah L Benyon, Michael S Irwin, Amit Agrawal, Parto Forouhi, Charles M Malata
BACKGROUND: Reconstructive breast surgery has continued to evolve over the last decade with a key change being the adoption of acellular dermal matrices (ADMs) as an adjunct for implant-based procedures. This retrospective observational study assesses the effect of ADMs on post-mastectomy reconstructive practice performed in a single institution. METHODS: We conducted a review of all patients undergoing breast reconstruction at a University Teaching Hospital for an 18-month period before and after adopting ADMs...
August 31, 2017: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/28917909/development-of-poly-1-8-octanediol-citrate-chitosan-blend-films-for-tissue-engineering-applications
#5
Ehsan Zeimaran, Sara Pourshahrestani, Belinda Pingguan-Murphy, Daniel Kong, Sangeetha Vasudevaraj Naveen, Tunku Kamarul, Nahrizul Adib Kadri
Blends of poly (1, 8-octanediol citrate) (POC) and chitosan (CS) were prepared through solution casting technique. Films with different component fractions (POC/CS: 100/0, 90/10, 80/20, 70/30, 60/40, and 0/100) were successfully prepared and characterized for their mechanical, thermal, structural and morphological properties as well as biocompatibility. The incorporation of CS to POC significantly increased tensile strength and elastic modulus and presented limited influences on pH variation which is important to the biocompatibility of biomaterial implants...
November 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28916881/a-3d-mammometric-comparison-of-implant-based-breast-reconstruction-with-and-without-acellular-dermal-matrix-adm
#6
Cynthia Tsay, Victor Zhu, Tracy Sturrock, Ajul Shah, Stephanie Kwei
This retrospective study utilizes 3D imaging and mammometrics to compare implant-based breast reconstruction with and without the use of ADM. Previous studies have suggested improved aesthetic outcomes with the use of ADM, but none have been able to quantify this difference. Images were obtained at early and late time points following the expander-implant exchange procedure. Measurements included the point of maximum projection, the superior, inferior, medial and lateral volumetric distribution, and the distance from the point of maximum projection to the inframammary fold along the breast meridian...
September 15, 2017: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/28916851/commentary-application-of-human-acellular-breast-dermal-matrix-abdm-in-implant-based-breast-reconstruction-an-experimental-study
#7
Chad M Bailey, Lee L Q Pu
No abstract text is available yet for this article.
September 15, 2017: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/28915955/implications-of-bisphosphonate-calcium-ion-depletion-interfering-with-desmosome-epithelial-seal-in-osseointegrated-implants-and-pressure-ulcers
#8
Louis Z G Touyz, Kelvin I Afrashtehfar
Osteoporosis (OP) is a global bone disease prevalent in aging in humans, especially in older women. Bisphosphonates (BPs) are commonly used as therapy for OP as it influences hard and soft tissues calcium metabolism. Mucosal and dermal ulceration with exposure of underlying bone arises from incomplete epithelial recovery due to reduced desmosome formation deriving from lack of available calcium. Pathological situations such as bisphosphonate-related osteonecrosis of the jaw have been described. This hypothesis states other situations which demand intact functional desmosomes such as healing skin over chronic pressure points leading to pressure ulcers (as well-known as bedsores, pressure sores, pressure injuries, decubitus ulcers), and hemidesmosomes such as epithelial seals in contact with titanium surfaces will have a higher prevalence of breakdown among patients being treated with BPs...
September 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/28915281/precision-in-dermal-filling-a-comparison-between-needle-and-cannula-when-using-soft-tissue-fillers
#9
Tatjana Pavicic, Konstantin Frank, Katharina Erlbacher, Romy Neuner, Stefan Targosinski, Thilo Schenck, Robert H Gotkin, Sebastian Cotofana
BACKGROUND: Precise implantation of soft tissue fillers to treat the signs of aging is crucial for patient safety and the best aesthetic outcome. Injections are performed commonly with either needles or cannulas, but quantitative comparative data on precise implantation are still elusive. METHODS: Ten fresh-frozen cephalic foreheads (9 male, 1 female) were injected with radiopaque material using both needles and cannulas. Needle injection relied on a perpendicular transcutaneous approach, whereas cannulas were moved in the supra-periosteal plane until reaching the same location as the needle...
September 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28905805/a-novel-model-of-acellular-dermal-matrix-plug-for-anal-fistula-treatment-report-of-a-case-and-surgical-consideration-based-on-first-utility-in-poland
#10
Adam Bobkiewicz, Łukasz Krokowicz, Maciej Borejsza-Wysocki, Tomasz Banasiewicz
Anal fistula (AF) is a pathological connection between anus and skin in its surroundings. The main reason for the formation of anal fistula is a bacterial infection of the glands within the anal crypts. One of the modern techniques for the treatment of fistulas that do not interfere with the sphincters consists in implantation of a plug made from collagen material. We are presenting the first Polish experience with a new model of biomaterial plug for the treatment of anal fistula. We also point out key elements of the procedure (both preoperative and intraoperative) associated with this method...
August 31, 2017: Polski Przeglad Chirurgiczny
https://www.readbyqxmd.com/read/28892228/immediate-nipple-reconstruction-in-combination-with-implant-reconstruction-using-dermal-sling
#11
George Filobbos, Nathan Hamnett, Joseph Hardwicke, Joanna Skillman
The inferior de-epithelialized dermal flap with implant is increasingly used for immediate breast reconstruction. We have adapted the technique to provide concurrent immediate nipple reconstruction by recruiting the triangle of skin above the excised nipple as a modified C-V flap. The safety and efficacy of this technique has been assessed in 15 patients, of which eight were bilateral and seven were unilateral cases. We suggest that this is a safe, reliable, and original technique for immediate nipple reconstruction in patients undergoing immediate breast reconstruction with an inferior dermal sling and implant...
September 11, 2017: Breast Journal
https://www.readbyqxmd.com/read/28874630/decellularized-human-dermal-matrix-produced-by-a-skin-bank-a-new-treatment-for-abdominal-wall-defects
#12
Martina Ghetti, Elena Bondioli, Valeria Purpura, Giovanna Cenacchi, Paolo Ruscelli, Davide Melandri
BACKGROUND: Interest is increasing for human decellularized scaffolds for their ability to favor healing and cell infiltration after transplantation, in the treatment of abdominal wall defects. The purpose of the present study is to show the clinical results obtained after the application of human decellularized dermal matrix (HDM) produced by RER Skin Bank, on patients suffering from different abdominal wall defects. METHODS: Between 2012 and 2014, 64 patients, average age 64 years, received HDM, to replace and cover the damage area during abdominal wall surgery...
July 25, 2017: Annali Italiani di Chirurgia
https://www.readbyqxmd.com/read/28874184/multipotent-stromal-cells-mesenchymal-stem-cells-and-fibroblasts-combine-to-minimize-skin-hypertrophic-scarring
#13
Cecelia C Yates, Melanie Rodrigues, Austin Nuschke, Zariel I Johnson, Diana Whaley, Donna Stolz, Joseph Newsome, Alan Wells
BACKGROUND: Transplantation of mesenchymal stem cells (MSC) has been proposed to improve wound healing. However, as these cells only transiently survive in the implantation site, the mechanisms underlying this beneficial healing response are associated with restorative paracrine effects of MSC matricellular factors on resident stromal cells. However, this requires that the recipient has a robust reservoir of viable cells. Here, we examine the influence of MSCs on the behavior of cotransplanted fibroblasts, in a manner to provide augmented cellular reserve to debilitated individuals, specifically focusing on matrix remodeling following in-vivo wounding...
September 5, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28831365/comparative-study-of-prepectoral-and-subpectoral-expander-based-breast-reconstruction-and-clavien-iiib-score-outcomes
#14
Lynne N Bettinger, Linda M Waters, Stephen W Reese, Susan E Kutner, Daniel I Jacobs
Prepectoral breast reconstruction is increasingly popular. This study compares complications between 2 subpectoral and 1 prepectoral breast reconstruction technique. METHODS: Between 2008 and 2015, 294 two-staged expander breast reconstructions in 213 patients were performed with 1 of 3 surgical techniques: (1) Prepectoral, (2) subpectoral with acellular dermal matrix (ADM) sling ("Classic"), or (3) subpectoral/subserratus expander placement without ADM ("No ADM"). Demographics, comorbidities, radiation therapy, and chemotherapy were assessed for correlation with Clavien IIIb score outcomes...
July 2017: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/28831349/a-limited-submuscular-direct-to-implant-technique-utilizing-allomax
#15
Michal Brichacek, Kimberly Dalke, Edward Buchel, Thomas E J Hayakawa
This study evaluates a novel limited submuscular direct-to-implant technique utilizing AlloMax where only the upper few centimeters of the implant is covered by the pectoralis, whereas the majority of the implant including the middle and lower poles are covered by acellular dermal matrix. METHODS: The pectoralis muscle is released off its inferior and inferior-medial origins and allowed to retract superiorly. Two sheets of AlloMax (6 × 16 cm) are sutured together and secured to the inframammary fold, serratus fascia, and the superiorly retracted pectoralis...
July 2017: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/28831348/animation-deformity-in-postmastectomy-implant-based-reconstruction
#16
Lauren C Nigro, Nadia P Blanchet
Despite increasing interest in prepectoral implant-based reconstruction to avoid animation deformity (AD), the prevalence of this deformity and patient attitudes toward it have not been extensively studied. The purpose of this study was to report on AD in the breast reconstruction population and identify those at highest risk. METHODS: A retrospective chart review was completed for patients at least 6 months postoperative from subpectoral, implant-based breast reconstruction using acellular dermal matrix in the lower pole...
July 2017: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/28831335/subcutaneously-placed-breast-implants-after-a-skin-sparing-mastectomy-do-we-always-need-adm
#17
Apresh Singla, Animesh Singla, Eric Lai, David Caminer
Immediate breast reconstruction is an acceptable treatment option after mastectomy for prophylaxis of early breast cancer. Different options exist for implant placement, incision technique, patient suitability, and institutional experience. This article is a case series exploring the feasibility and outcomes of patients undergoing immediate breast reconstruction using skin-sparing mastectomy without mesh or acellular dermal matrix (ADM) and with a vertical inframammary incision. METHODS: A single-institution retrospective analysis was performed for all patients who underwent immediate single-stage reconstruction with subcutaneous silicon implants without ADM between 2009 and 2014 inclusive...
July 2017: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/28820815/direct-to-implant-breast-reconstruction-without-the-use-of-an-acellular-dermal-matrix-is-cost-effective-and-oncologically-safe
#18
Domenico Parisi, Francesco Ciancio, Aurelio Portincasa, Alessandro Innocenti
No abstract text is available yet for this article.
August 9, 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28812172/delayed-post-mastectomy-breast-reconstructions-with-allogeneic-acellular-dermal-matrix-prepared-by-a-new-decellularizationmethod
#19
Martin Bohac, Ivan Varga, Stefan Polak, Jana Dragunova, Jozef Fedeles, Jan Koller
Acellular dermal matrix (ADM) is a tissue graft of allogeneic origin from post-mortem tissue donors prepared by an innovative decellularization process. The newly developed non-toxic and low cost decellularization process of cadaver origin dermis included ADM in breast reconstruction procedures proved to help coverage of the lower-pole of breast expanders or implants. As the results have shown, it did help to eliminate autologous dermis donor site morbidity along with shortening the operation time by avoiding elevation of additional muscle or fascia during the operation...
August 16, 2017: Cell and Tissue Banking
https://www.readbyqxmd.com/read/28810287/seeding-density-is-a-crucial-determinant-for-the-in-vivo-vascularisation-capacity-of-adipose-tissue-derived-microvascular-fragments
#20
T Später, C Körbel, F S Frueh, R M Nickels, M D Menger, M W Laschke
Adipose tissue-derived microvascular fragments (ad-MVF) represent effective vascularisation units for the seeding of dermal substitutes. However, particularly in case of extensive skin defects, the required amounts of donor fat tissue for the harvesting of ad-MVF may not always be available. Therefore, we herein determined the lowest ad-MVF density needed to induce a sufficient vascularisation and incorporation of seeded implants. Collagen-glycosaminoglycan matrices (Integra®; diameter: 4 mm) were seeded with 15,000 (HD), 10,000 (MD) and 5,000 (LD) ad-MVF and implanted into full-thickness skin defects within mouse dorsal skinfold chambers, to analyse their in vivo vascularisation and incorporation...
August 15, 2017: European Cells & Materials
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