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Dermal Implants

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https://www.readbyqxmd.com/read/29124378/usefulness-of-cross-linked-human-acellular-dermal-matrix-as-an-implant-for-dorsal-augmentation-in-rhinoplasty
#1
Chae Eun Yang, Soo Jung Kim, Ji Hee Kim, Ju Hee Lee, Tai Suk Roh, Won Jai Lee
BACKGROUND: Asian noses are relatively small and flat compared to Caucasians; therefore, rhinoplasty procedures often focus on dorsal augmentation and tip projection rather than reduction in the nasal framework. Various autologous and alloplastic implant materials have been used for dorsal augmentation. Recently, human acellular dermal matrices have been introduced as an implant material for dorsal augmentation, camouflaging autologous implants without an additional donor site. Here, we introduce a cross-linked human acellular dermal matrix as an implant material in augmentation rhinoplasty and share the clinical experiences...
November 9, 2017: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/29109028/enhancing-immunogenicity-of-antigens-through-sustained-intradermal-delivery-using-chitosan-microneedles-with-a-patch-dissolvable-design
#2
Mei-Chin Chen, Kuan-Ying Lai, Ming-Hung Ling, Chun-Wei Lin
Reducing the dosage required for vaccination is highly desirable, particularly in cases of epidemic emergencies. This study evaluated the potential of a chitosan microneedle (MN) system with a patch-dissolvable design for low-dose immunization. This system comprises antigen-loaded chitosan MNs and a hydrophilic polyvinyl alcohol/polyvinyl pyrrolidone supporting array patch, which provides extra strength to achieve complete MN insertion and then quickly dissolves in the skin to reduce patch-induced skin irritation...
November 3, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/29101440/usefulness-of-crosslinked-human-acellular-dermal-matrix-as-an-implant-for-dorsal-augmentation-and-rhinoplasty
#3
Darryl J Hodgkinson
No abstract text is available yet for this article.
November 3, 2017: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/29098159/one-stage-immediate-breast-reconstruction-a-concise-review
#4
REVIEW
Nicolò Bertozzi, Marianna Pesce, Pierluigi Santi, Edoardo Raposio
Background: One-stage direct-to-implant immediate breast reconstruction (IBR) is performed simultaneously with breast cancer resection. We explored indications, techniques, and outcomes of IBR to determine its feasibility, safety, and effectiveness. Material and Methods: We reviewed the available literature on one-stage direct-to-implant IBR, with or without acellular dermal matrix (ADM), synthetic mesh, or autologous fat grafting. We analyzed the indications, preoperative work-up, surgical technique, postoperative care, outcomes, and complications...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29090119/a-review-on-the-toxicology-and-dietetic-role-of-bacterial-cellulose
#5
REVIEW
Fernando Dourado, Miguel Gama, Ana Cristina Rodrigues
Bacterial cellulose (BC) is a biopolymer synthesized by certain acetic acid bacteria strains. The safety of BC regarding its potential use in food applications is here reviewed. The acute, sub-acute and subchronic oral toxicity assays showed that consumption of BC had no adverse effects in rats. Several studies demonstrated that BC is not genotoxic, did not induce chromosomal aberrations in CHO cells under both non-activating and metabolic activating conditions, is inactive in the in vitro Rat Primary Hepatocyte Unscheduled DNA Synthesis Assay, had no reproductive toxicity in mice and exerted no embryotoxicity and teratogenicity effects in rats...
2017: Toxicology Reports
https://www.readbyqxmd.com/read/29080661/the-use-of-tigr-matrix-in-breast-aesthetic-and-reconstructive-surgery-is-a-resorbable-synthetic-mesh-a-viable-alternative-to-acellular-dermal-matrices
#6
REVIEW
Stefano Pompei, Dora Evangelidou, Floriana Arelli, Gianluigi Ferrante
The authors document their experience in the use of synthetic 100% bioresorbable surgical mesh (TIGR Matrix, Novus Scientific, Uppsala, Sweden) in breast reconstruction as well as in breast aesthetic surgery. They performed a retrospective review on patients who underwent implant-based breast reconstruction as well as patients who underwent breast reduction mammoplasty procedures with the use of TIGR Matrix Surgical Mesh. When compared with other synthetic but nonresorbable meshes, it appears to show a potentially lower seroma and infection rates, but most importantly, a lower rate of revisional and mesh explantation surgeries...
January 2018: Clinics in Plastic Surgery
https://www.readbyqxmd.com/read/29080660/indications-and-controversies-for-implant-based-breast-reconstruction-utilizing-biological-meshes
#7
REVIEW
Michael R Zenn
The advent of acellular dermal matrices (ADMs) has changed the way implant reconstruction is performed and has opened the door to muscle-sparing techniques that can be performed as an NSM (nipple-sparing mastectomy) with DTI (direct to implant) with excellent cosmesis and less patient morbidity. The article discusses differences in types of ADMs and outlines some current strategies and controversies with ADM use.
January 2018: Clinics in Plastic Surgery
https://www.readbyqxmd.com/read/29076632/a-novel-model-of-humanised-keloid-scarring-in-mice
#8
Tao Shang, Bin Yao, Dongyun Gao, Jiangfan Xie, Xiaobing Fu, Sha Huang
Treatments for keloid scarring are a major challenge to scientists and physicians for their unknown aetiology. Although several models, including monolayer cell culture to tissue-engineered models, were developed, further research on keloid has more or less been hindered by the lack of appropriate animal models. Because these aberrant scars are specific to humans, we obtained human normal and keloid skin tissues and isolated dermal fibroblasts from them. Cell morphology, growth and immunohistochemical staining of myofibroblastmarker α-SMA were examined, and the cell medium of 2-hour culture and 24-hour culture was implanted on the back of nude mice...
October 27, 2017: International Wound Journal
https://www.readbyqxmd.com/read/29076316/salvage-of-infected-breast-implants
#9
Joon Ho Song, Young Seok Kim, Bok Ki Jung, Dong Won Lee, Seung Yong Song, Tai Suk Roh, Dae Hyun Lew
Background: Implant-based breast reconstruction is being performed more frequently, and implants are associated with an increased risk of infection. We reviewed the clinical features of cases of implant infection and investigated the risk factors for breast device salvage failure. Methods: We retrospectively analyzed 771 patients who underwent implant-based breast reconstruction between January 2010 and December 2016. Age, body mass index, chemotherapy history, radiation exposure, and smoking history were assessed as potential risk factors for postoperative infection...
October 27, 2017: Archives of Plastic Surgery
https://www.readbyqxmd.com/read/29075819/augmentation-mastopexy-with-a-dermal-encapsulated-round-or-anatomic-autoprosthesis
#10
Safvet Ors
INTRODUCTION: Several factors, such as aging, pregnancy, and weight loss, reduce the elasticity of the breast tissue, and ptosis occurs. Due to aging and gravity, it is not possible to completely prevent breast ptosis. The goal is to delay the recurrence of ptosis as much as possible. PATIENTS AND METHODS: This study included 20 female patients aged 25-55 years. The patients who underwent surgery had different levels of ptosis. Although the patients wanted their breasts to be lifted and an increase in projection, they did not want implants to be used...
October 26, 2017: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/29070989/muscle-sparing-adm-assisted-breast-reconstruction-technique-using-complete-breast-implant-coverage-a-dual-institute-uk-based-experience
#11
Raghavan Vidya, Simon J Cawthorn
BACKGROUND: We report our early experience of a novel muscle-sparing breast (prepectoral) reconstruction technique using a pre-shaped Braxon® mesh (acellular dermal matrix) which completely wraps around the breast implant. METHODS: All patients who underwent prepectoral implant-based breast reconstruction between April 2014 and September 2015 were included in the analysis. The dermal matrix Braxon® used is a pre-shaped matrix which forms a complete implant mesh wrap...
September 2017: Breast Care
https://www.readbyqxmd.com/read/29068929/effect-of-compound-21-a-selective-angiotensin-ii-type-2-receptor-agonist-in-a-murine-xenograft-model-of-dupuytren-disease
#12
Jessica Chisholm, Alison J Gareau, Stephanie Byun, Justin L Paletz, David Tang, Jason Williams, Terry LeVatte, Michael Bezuhly
BACKGROUND: Although surgical excision and intralesional collagenase injection are mainstays in Dupuytren disease treatment, no effective medical therapy exists for recurrent disease. Compound 21, a selective agonist of the angiotensin II type 2 receptor, has been shown to protect against fibrosis in models of myocardial infarction and stroke. The authors investigated the potential use of compound 21 in the treatment of Dupuytren disease. METHODS: Human dermal fibroblasts were treated in vitro with compound 21 and assessed for viability using a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, migration by means of scratch assay, and profibrotic gene transcription by means of quantitative reverse transcription polymerase chain reaction...
November 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29067472/a-novel-and-more-aesthetic-injection-pattern-for-malar-cheek-volume-restoration
#13
Ava Shamban, Mike D Clague, Erika von Grote, Alessandra Nogueira
The loss of superior midface contour and projection can be corrected with the use of injectable hyaluronic acid (HA) dermal fillers, however, the most frequently used injection pattern employs a technique which was originally designed for malar implant surgery. Here we describe a novel injection pattern for restoring facial contours with a HA dermal filler inspired by traditional make-up artistry, which includes greater superolateral positioning of injection sites. Importantly, this technique helps injectors avoid creating an excess of volume in the anterior portion of the malar complex...
October 24, 2017: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/29064921/nipple-sparing-mastectomy-and-direct-to-implant-breast-reconstruction
#14
REVIEW
Amy S Colwell, Joani M Christensen
Breast reconstruction following mastectomy has evolved to preserve the native skin and nipple of the breast and create a natural-appearing reconstruction in 1 or 2 surgeries. Nipple-sparing procedures appear to be oncologically safe with low risks of cancer recurrence. In our series of 2,182 nipple-sparing mastectomies, there was no development or recurrence of cancer in the nipple. Direct-to-implant single-stage surgery offers the patient a complete reconstruction at the time of mastectomy. Patient selection centers on preoperative breast anatomy combined with postoperative goals for size and uplift of the breast...
November 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29064920/what-s-new-in-acellular-dermal-matrix-and-soft-tissue-support-for-prosthetic-breast-reconstruction
#15
REVIEW
John Y S Kim, Alexei S Mlodinow
Of the nearly 90,000 implant-based breast reconstructions performed in the United States, the majority use internal soft-tissue support. Aesthetically, these constructs may allow for better positioning of prosthesis, improve lower pole expansion, and increase projection. They may have particular utility in direct-to-implant, nipple-sparing mastectomies, and prepectoral reconstructions. In recent years, new permutations of acellular dermal matrices have evolved with diverse shapes, sizes, form-factor innovations, and processing characteristics...
November 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29062655/prepectoral-implant-based-breast-reconstruction
#16
Lyndsey Highton, Richard Johnson, Cliona Kirwan, John Murphy
BACKGROUND: The development of acellular dermal matrices (ADMs) has facilitated single-stage implant breast reconstruction (IBR) following skin-sparing mastectomy. The conventional approach of postpectoral implant placement with lower pole ADM confers a good cosmetic result by improving lower pole projection and control, while minimizing issues of implant visibility, palpability, and rippling. This is balanced with potential disadvantages including pain, disruption of pectoral muscle function, and animation...
September 2017: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/29062631/immediate-nipple-areolar-complex-reconstruction-for-patients-undergoing-implant-based-reconstruction-or-therapeutic-mammoplasty
#17
Lyndsey R Highton, John A Murphy
BACKGROUND: We report a technique of immediate nipple-areolar complex (NAC) reconstruction for patients undergoing skin-sparing mastectomy and implant-based breast reconstruction or therapeutic mammoplasty with central excision. METHODS: Immediate nipple reconstruction is performed using a modified C-V flap planned along the edge of the incision. The areola is reconstructed using a full-thickness skin graft taken from skin usually discarded during the procedure...
September 2017: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/29059143/polyalkylimide-a-nonstable-filler-over-time
#18
Leonie W Schelke, Peter J Velthuis, Marijke R van Dijk
BACKGROUND: Polyalkylimide hydrogel is supposed to be a permanent, biocompatible implant. However, years after subcutaneous implantation clinical complications are seen. OBJECTIVE: To increase the understanding of the changes that occur over time in this subdermal implanted filler. MATERIALS AND METHODS: The extruded filler material of 34 patients was evaluated by histologic examination. RESULTS: In most patients who had cosmetic disturbances but no complaints, histology showed no immune cells in or around the filler material...
October 20, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/29037204/thoracodorsal-artery-perforator-flap-as-an-autologous-alternative-to-acellular-dermal-matrix
#19
Tarek Hashem, Ahmed Farahat
BACKGROUND: Thoracodorsal artery perforator (TDAP) flap is one of the relatively new techniques in breast reconstruction. This pedicled flap retains the benefits of perforator flaps as regards minimal donor site morbidity without the need for microvascular anastomosis. Its role in partial breast reconstruction has been well documented. However, there are few reports about the role of this flap in total breast reconstruction. METHODS: This study included 47 cases who presented to the breast unit of the National Cancer Institute of Cairo University from 2013 to 2015...
October 16, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29032112/dermal-pharmacokinetics-of-pyrazinamide-determined-by-microdialysis-sampling-in-rats
#20
Nivea M F Voelkner, Alexander Voelkner, Juliana Costa, Sherwin K B Sy, Juliane Hermes, Johanna Weitzel, Sebastian Morales, Hartmut Derendorf
Studies have demonstrated pyrazinamide's efficacy against stages of the parasite which causes cutaneous leishmaniasis. Although pyrazinamide is widely distributed to most fluids and tissues, the drug distribution that reaches the skin is unknown. The aim of this study was to investigate pyrazinamide pharmacokinetics in rat dermal tissue by dermal microdialysis. Skin pharmacokinetics were assessed by implanting a linear microdialysis probe in the dermis of ten rats. Additionally, blood samples were collected for assessing plasma pharmacokinetics...
October 12, 2017: International Journal of Antimicrobial Agents
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