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Dermal Implants

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https://www.readbyqxmd.com/read/29450975/tropoelastin-implants-that-accelerate-wound-repair
#1
Suzanne M Mithieux, Behnaz Aghaei-Ghareh-Bolagh, Leping Yan, Kekini V Kuppan, Yiwei Wang, Francia Garces-Suarez, Zhe Li, Peter K Maitz, Elizabeth A Carter, Christina Limantoro, Wojciech Chrzanowski, David Cookson, Alan Riboldi-Tunnicliffe, Clair Baldock, Kosuke Ohgo, Kristin K Kumashiro, Glenn Edwards, Anthony S Weiss
A novel, pure, synthetic material is presented that promotes the repair of full-thickness skin wounds. The active component is tropoelastin and leverages its ability to promote new blood vessel formation and its cell recruiting properties to accelerate wound repair. Key to the technology is the use of a novel heat-based, stabilized form of human tropoelastin which allows for tunable resorption. This implantable material contributes a tailored insert that can be shaped to the wound bed, where it hydrates to form a conformable protein hydrogel...
February 16, 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29449959/sulfobetaine-methacrylate-hydrogel-coated-anti-fouling-surfaces-for-implantable-biomedical-devices
#2
Se Yeong Lee, Yunki Lee, Phuong Le Thi, Dong Hwan Oh, Ki Dong Park
Background: Zwitterionic molecules have been widely studied as coating materials for preparing anti-fouling surfaces because they possess strong hydration properties that can resist non-specific protein adsorption. Numerous studies on surface modification using zwitterionic molecules have been investigated, such as electrochemically mediated and photoinitiated radical polymerization. However, these methods have some limitations, including multi-step process, difficulties in producing thick and dense layers as well as the requirement of extra facilities...
2018: Biomaterials Research
https://www.readbyqxmd.com/read/29434662/novel-devices-for-implant-based-breast-reconstruction-is-the-use-of-meshes-to-support-the-lower-pole-justified-in-terms-of-benefits-a-review-of-the-evidence
#3
REVIEW
Lorna Jane Cook, Tibor Kovacs
The use of novel devices such as acellular dermal matrices (ADMs) to support the lower pole in implant-based breast reconstructions (IBBRs) has been described as one of the most important advances in breast reconstructive surgery following mastectomy. However, the majority of outcomes studies focus primarily on providing evidence for the rates of short-term complications associated with their use, as opposed to their reported benefits. Given the high costs associated with using ADMs, together with an increasing number of alternative, cheaper synthetic products entering the market, it is important to clarify whether their use is actually justified and whether the alternative products offer equivalent or superior outcomes...
2018: Ecancermedicalscience
https://www.readbyqxmd.com/read/29428676/controlled-release-of-collagen-binding-sdf-1%C3%AE-from-the-collagen-scaffold-promoted-tendon-regeneration-in-a-rat-achilles-tendon-defect-model
#4
Jie Sun, Chenchen Mou, Qin Shi, Bing Chen, Xianglin Hou, Wen Zhang, Xiaoran Li, Yan Zhuang, Jiajia Shi, Yanyan Chen, Jianwu Dai
It had been demonstrated that stromal cell-derived factor-1α (SDF-1α) could promote in situ tendon regeneration by recruiting endogenous cells. However, native SDF-1α diffuses too fast in vivo, reducing its local concentration and efficacy. In this study, we prepared a recombinant SDF-1α containing a collagen-binding domain (CBD-SDF-1α) and developed a functional collagen scaffold by tethering CBD-SDF-1α on the collagen scaffold for in situ tendon regeneration. CBD-SDF-1α could induce the migration of mesenchymal stem cells, dermal fibroblasts and Achilles tendon fibroblasts in vitro, and achieve controlled release from the collagen scaffold...
February 4, 2018: Biomaterials
https://www.readbyqxmd.com/read/29397895/the-evolving-role-of-pre-pectoral-adm-assisted-implant-based-immediate-breast-reconstruction-following-skin-sparing-mastectomy
#5
Umar Wazir, Kefah Mokbel
INTRODUCTION: The increasing use of acellular dermal matrix (ADM) and fat transfer in the context of breast reconstruction, following skin sparing mastectomy (SSM) for therapeutic and risk reducing purposes, combined with the need to eliminate animation deformities, reduce post-operative dysfunctional pain and the risk of capsular contracture, has prompted surgeons to investigate the possibility of placing the mammary implant over the pectoralis major muscle with complete coverage with ADM thus reviving the pre-pectoral approach which was previously abandoned due to high complications rates and poor aesthetics in the pre-ADM era...
February 2, 2018: American Journal of Surgery
https://www.readbyqxmd.com/read/29389701/evaluation-of-modifications-to-tissue-expander-breast-reconstruction-a-quality-improvement-assessment-within-a-private-practice
#6
Henry Wilson, Adam Varnadore
BACKGROUND: As technology advances, surgical practice evolves over time. The author assesses a new approach to implant-based breast reconstruction and the impact of two changes implemented over several years. METHODS: A series of tissue-expander reconstructions performed early in the author's experience were retrospectively compared with a similar number of cases prospectively performed. Demographics, perioperative characteristics, and postoperative outcomes were assessed...
January 31, 2018: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29379910/nanocomposite-injectable-gels-capable-of-self-replenishing-regenerative-extracellular-microenvironments-for-in-vivo-tissue-engineering
#7
Koji Nagahama, Naho Oyama, Kimika Ono, Atsushi Hotta, Keiko Kawauchi, Takahito Nishikata
Injectable hydrogels are biomaterials that have the potential to provide scaffolds to cells for in situ tissue regeneration with a minimally invasive implantation procedure. The success of in vivo tissue engineering utilizing injectable gels depends on providing cells with appropriate scaffolds that present an instructive extracellular microenvironment, which strongly influences the survival, proliferation, organization, and function of cells encapsulated within gels. One of the most important abilities of injectable gels to achieve this function is to adsorb and retain a wide variety of requisite bioactive molecules including nutrients, extracellular matrices, and growth/differentiation factors within gels...
January 30, 2018: Biomaterials Science
https://www.readbyqxmd.com/read/29369979/the-comparison-of-strattice-and-surgimend-in-acellular-dermal-matrix-assisted-implant-based-immediate-breast-reconstruction
#8
Fayyaz A K Mazari, Ghulam M Wattoo, Nazar H Kazzazi, Kadappa M Kolar, Olumuyiwa O Olubowale, Clare E Rogers, Iman A Azmy
BACKGROUND: Strattice (porcine derivative) and SurgiMend (bovine derivative) are the two most common acellular dermal matrices used in breast reconstruction in the United Kingdom. This retrospective study compared clinical outcomes in immediate implant-based breast reconstruction patients. METHODS: The study, conducted across three hospitals, included all patients who underwent immediate implant-based breast reconstruction using Strattice and SurgiMend. The primary outcome measure was implant loss rate...
February 2018: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29369110/moffitt-cancer-center-experience-of-tissue-expander-breast-reconstruction-does-acellular-dermal-matrix-increase-return-to-the-operating-room
#9
Brielle Weinstein, Ambuj Kumar, Paul Smith, Deniz Dayicioglu
BACKGROUND: Tissue expander and implant remains the most common technique for breast reconstruction. A controversial topic within this method is routine use of acellular dermal matrix (ADM). Acellular dermal matrices have increased risks of infection, seroma, hematoma, skin flap necrosis, and total complications. METHODS: After an institutional review board approval, a retrospective chart review was conducted of 756 tissue expander with implant cases from November 2010 to November 2016 at Moffitt Cancer Center with 2 breast reconstruction surgeons...
January 24, 2018: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29368031/efficacy-of-partial-versus-full-sling-acellular-dermal-matrix-use-in-implant-based-breast-reconstruction-a-head-to-head-comparison
#10
Kyeong-Tae Lee, Yeseul Eom, Goo-Hyun Mun, Sa Ik Bang, Byung-Joon Jeon, Jai-Kyong Pyon
BACKGROUND: Acellular dermal matrix (ADM), popularly used in tissue expander-based breast reconstruction, is applied either as a partial or full sling, but without any consensus regarding which method of application produces better outcomes. We aimed to compare the outcomes between two patient groups who underwent tissue expander-based breast reconstruction using these techniques. METHODS: A retrospective review was conducted for consecutive patients who underwent immediate two-stage implant-based breast reconstruction using ADM between January 2013 and June 2016...
January 24, 2018: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/29365064/prepectoral-revision-breast-reconstruction-for-treatment-of-implant-associated-animation-deformity-a-review-of-102-reconstructions
#11
Allen Gabriel, Steven Sigalove, Noemi M Sigalove, Toni L Storm-Dickerson, Jami Rice, Nicole Pope, G Patrick Maxwell
Background: Animation deformity is a direct consequence of subpectoral implant placement for breast reconstruction following mastectomy. Current treatment options ameliorate but do not address the source of the problem. Moving the implant from subpectoral to prepectoral has the potential to eliminate animation deformity. Objectives: Describe the technique and outcomes of prepectoral revision reconstruction in over 100 cases and discuss patient selection criteria for a successful outcome...
January 20, 2018: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/29335394/landscape-of-oncoplastic-breast-surgery-across-poland
#12
Agnieszka Kolacinska, Diana Hodorowicz-Zaniewska, Artur Bocian, Dariusz Michalik, Rafal Matkowski, Andrzej Kurylcio, Pawel Pyka, Michal Charytonowicz, Maciej Berkan
Oncoplastic and reconstructive techniques are essential tools in the armamentarium of contemporary breast surgeons. The aim of the study was to identify oncoplastic reconstructive patterns in breast cancer centers across Poland. A questionnaire of 18 questions was sent by email to the members of the Polish Society of Surgical Oncology and the Polish Society of Plastic, Reconstructive and Esthetic Surgery via their dedicated websites. The numbers of breast cancer patients operated on in each center ranged from 120 to 904 per year...
December 30, 2017: Polski Przeglad Chirurgiczny
https://www.readbyqxmd.com/read/29320921/benefits-and-risks-with-acellular-dermal-matrix-adm-and-mesh-support-in-immediate-breast-reconstruction-a-systematic-review-and-meta-analysis
#13
Håkan Hallberg, Svanheidur Rafnsdottir, Gennaro Selvaggi, Annika Strandell, Ola Samuelsson, Ida Stadig, Therese Svanberg, Emma Hansson, Richard Lewin
In modern implant-based immediate breast reconstruction, it has become common to use biological acellular dermal and synthetic matrices in combination with a tissue expander or an implant. The aim of this systematic review was to examine differences in recurrence of cancer, impact on oncological treatment, health related quality of life, complications and aesthetic outcome between matrix and no matrix in immediate breast reconstruction. Systematic searches, data extraction and assessment of methodological quality were performed according to predetermined criteria...
January 10, 2018: Journal of Plastic Surgery and Hand Surgery
https://www.readbyqxmd.com/read/29302735/a-new-human-derived-acellular-dermal-matrix-for-breast-reconstruction-available-for-the-european-market-preliminary-results
#14
Secondo Folli, Annalisa Curcio, Davide Melandri, Elena Bondioli, Nicola Rocco, Giuseppe Catanuto, Fabio Falcini, Valeria Purpura, Matteo Mingozzi, Federico Buggi, Francesco Marongiu
INTRODUCTION: The introduction of acellular dermal matrices (ADMs) contributed to the growing diffusion of direct-to-implant breast reconstruction (DTI-BR) following mastectomy for breast cancer. According to specific legislations, European specialists could not benefit from the use of human-derived ADMs, even though most evidence in the literature are available for this kind of device, showed optimal outcomes in breast reconstruction. The Skin Bank of the Bufalini Hospital (Cesena, Italy) obtained in 2009 the approval for the production and distribution of a new human cadaver-donor-derived ADM (named with the Italian acronym, MODA, for matrice omologa dermica acellulata) from the Italian National Transplant Center and National Health Institute...
January 4, 2018: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/29302486/early-multicentre-experience-of-pre-pectoral-implant-based-immediate-breast-reconstruction-using-braxon-%C3%A2
#15
Sadaf Jafferbhoy, Mihir Chandarana, Maria Houlihan, Rishikesh Parmeshwar, Sankaran Narayanan, Soni Soumian, Simon Harries, Lucie Jones, Dayalan Clarke
Background: The last two decades have seen significant changes in surgical management of breast cancer. The offer of immediate breast reconstruction (IBR) following mastectomy is currently standard practice. Skin sparing and nipple sparing mastectomy with implant-based IBR have emerged as oncologically safe treatment options. Prepectoral implant placement and complete coverage of implant with acellular dermal matrix (ADM) eliminates the need to detach the muscle from underlying chest wall in contrast to the subpectoral technique...
December 2017: Gland Surgery
https://www.readbyqxmd.com/read/29280856/bovine-acellular-dermal-matrix-in-immediate-breast-reconstruction-a-retrospective-observational-study-with-surgimend
#16
Michael Scheflan, Helena Grinberg-Rashi, Keren Hod
BACKGROUND: Acellular dermal matrices can be combined with implant-based breast reconstruction to help optimize outcomes. SurgiMend PRS is a fetal bovine dermis-derived acellular dermal matrix composed of type I collagen and approximately 30 percent type III collagen, sharing many of the properties of human cadaveric acellular dermal matrix. METHODS: This was a retrospective, single-center analysis of 111 adult patients (147 breasts) undergoing one-stage (83.7 percent) or two-stage (16...
January 2018: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29275104/one-step-prepectoral-breast-reconstruction-with-dermal-matrix-covered-implant-compared-to-submuscular-implantation-functional-and-cost-evaluation
#17
Leonardo Cattelani, Susanna Polotto, Maria Francesca Arcuri, Giuseppe Pedrazzi, Chiara Linguadoca, Elena Bonati
BACKGROUND: The breast reconstructive subpectoral technique commonly leads to functional consequences. Recently, a new conservative prepectoral breast reconstruction (PPBR) technique was proposed and its surgical safety and aesthetic effectiveness proved. The aim of this prospective nonrandomized study was to compare the functional and economical outcomes of the PPBR procedure versus the subpectoral one. PATIENTS AND METHODS: From February 2015 to September 2016, 86 patients underwent mastectomy with immediate implant-based reconstruction...
December 2, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/29244224/osteochondral-repair-using-an-acellular-dermal-matrix-pilot-in-vivo-study-in-a-rabbit-osteochondral-defect-model
#18
Ken Ye, Kathy Traianedes, Shalley A Robins, Peter F M Choong, Damian E Myers
The aim of this pilot project was to introduce a novel use of acellular dermal matrix (ADM) in combination with infrapatellar fat pad mesenchymal stromal cells (IPFP-MSCs) to effect repair in a rabbit osteochondral defect model. ADM, in a range of surgical procedures, has been shown to promote remodelling of tissue at the site of implantation. Rabbit-derived ADM (rabADM) was prepared from the skin of donor rabbits. Autologous IPFP-MSCs were obtained at the time of knee surgery. Osteochondral defects (4mm cartilage outer/2mm central bone defect) were drilled into distal femoral condyles of 12 New Zealand White rabbits...
December 15, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29240203/scar-tissue-formation-following-alveolar-ridge-preservation-a-case-control-study
#19
Stefan Fickl, Frederic Kauffmann, Christian F Stappert, Anke Kauffmann, Ulrich Schlagenhauf
The aim of this retrospective case control study was to compare a porcine collagen matrix (Mucograft Seal, Geistlich) with a free gingival punch graft with respect to size, invagination, and color of resulting soft tissue scar formation. Following definition of inclusion and exclusion criteria, 22 patients were retrospectively included in this study. The patients were divided into two groups. In group A, the extraction socket was filled with bovine bone mineral (Bio-Oss, Geistlich) and covered with a free gingival punch graft...
January 2018: International Journal of Periodontics & Restorative Dentistry
https://www.readbyqxmd.com/read/29233522/subcutaneous-implant-based-breast-reconstruction-a-modern-challenge-in-postmastectomy-radiation-planning
#20
Melissa P Mitchell, Jamie Wagner, James Butterworth
PURPOSE: A growing trend in breast reconstruction has been placement of tissue expanders in the pre pectoral space. This is a change from the practice of placement under the pectoralis major with or without an acellular dermal matrix (ADM) sling. The move toward pre pectoral placement with an ADM wrap has the intent of decreasing post-operative pain and decreasing animation deformities. The cosmesis of pre pectoral reconstructions in the setting of post mastectomy radiation has also appeared improved in our early experience, when compared to submuscular reconstructions...
September 8, 2017: Practical Radiation Oncology
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