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Dermal Implants

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https://www.readbyqxmd.com/read/29666911/dual-coverage-of-the-inferior-pole-with-conjoined-fascial-flap-and-acellular-dermal-matrix-for-immediate-one-stage-breast-reconstruction-with-a-prosthetic-implant
#1
Seo H Lee, Yong S Chun, Heung K Park, Yang W Kim, Young W Cheon
BACKGROUND: Elevation of a conjoined fascial flap composed of the pectoralis major, serratus anterior, and external oblique fascia is a type of surgical technique using autologous tissue to cover the lower pole after immediate one-stage direct-to-implant (DTI) breast reconstruction. However, volumetric breast implants hinder use of this technique alone. For better structural stability and more aesthetically favorable breast contour in large breasts, we have devised a technique involving dual coverage of the lower pole by a conjoined fascial flap and acellular dermal matrix (ADM)...
April 17, 2018: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/29663320/predictors-of-complications-after-direct-to-implant-breast-reconstruction-with-an-acellular-dermal-matrix-from-a-multicentre-randomized-clinical-trial
#2
V L Negenborn, R E G Dikmans, M B Bouman, H A H Winters, J W R Twisk, P Q Ruhé, M A M Mureau, J M Smit, S Tuinder, J Hommes, Y Eltahir, N A S Posch, J M van Steveninck-Barends, M A Meesters-Caberg, R R W J van der Hulst, M J P F Ritt, M G Mullender
BACKGROUND: In the multicentre randomized trial BRIOS (Breast Reconstruction In One Stage), direct-to-implant (DTI) breast reconstruction with an acellular dermal matrix (ADM) was associated with a markedly higher postoperative complication rate compared with two-stage tissue expander/implant breast reconstruction. This study aimed to identify factors that contribute to the occurrence of complications after DTI ADM-assisted breast reconstruction. METHODS: Data were obtained from the BRIOS study, including all patients treated with DTI ADM-assisted breast reconstruction...
April 16, 2018: British Journal of Surgery
https://www.readbyqxmd.com/read/29659450/aseptic-freeze-dried-vs-sterile-wet-packaged-human-cadaveric-acellular-dermal-matrix-adm-in-immediate-tissue-expander-breast-reconstruction-a-propensity-score-analysis-study
#3
Summer E Hanson, Jesse D Meaike, Jesse C Selber, Jun Liu, Liang Li, Victor J Hassid, Donald P Baumann, Charles E Butler, Patrick B Garvey
BACKGROUND: Although multiple acellular dermal matrix (ADM) sources exist, it is unclear how ADM processing impacts complication rates. We compared complications between two preparations of human cadaveric ADM (freeze dried [hADM-FD] and ready to use [hADM-RTU]) in immediate tissue expander (TE) breast reconstruction to analyze the effect of processing on complications. HADM-FD is aseptic while hADM-RTU is sterilized and wet-packaged. METHODS: We retrospectively reviewed all TE breast reconstructions with hADM-FD or hADM-RTU at a single center between 2006 and 2016...
January 20, 2018: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29616167/patient-reported-outcomes-after-adm-assisted-implant-based-breast-reconstruction-a-cross-sectional-study
#4
Vera L Negenborn, Rieky E G Dikmans, Mark-Bram Bouman, Janneke A Wilschut, Margriet G Mullender, C Andrew Salzberg
Background: Although the use of acellular dermal matrices (ADMs) in implant-based reconstruction increases, there is a lack of studies evaluating patient-reported outcome measures after this reconstruction method. We aim to evaluate the patient satisfaction after ADM-assisted implant-based breast reconstruction (IBBR) in 1 of the largest series of patients undergoing ADM-assisted IBBR. Methods: Patients with ADM-assisted IBBR were invited to fill out the BREAST-Q, a validated and standardized questionnaire to measure patient satisfaction after a breast reconstruction...
February 2018: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/29579025/a-novel-small-animal-model-of-irradiated-implant-based-breast-reconstruction
#5
Kasandra R Dassoulas, Jessica S Wang, Madeline M Stovall, Serena S Lei, Jenna M Thuman, Lisa S Salopek, Patrick S Cottler, Angela Pineros-Fernandez, Taeho Kim, CheukKai B Hui, Anthony Archual, Kant Y Lin
PURPOSE: There is currently a need for a clinically relevant small animal model for irradiated, implant based breast reconstruction. Present models are inadequate in terms of suboptimal location of expander placement and mode of radiation delivery, correlating poorly with the human clinical scenario. We hypothesized that by delivering fractionated radiation and placing an expander under the scalp of the animal, we would achieve histologically analogous soft tissue changes seen in human irradiated, implant based breast reconstruction...
March 19, 2018: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29569868/what-happens-to-an-acellular-dermal-matrix-after-implantation-in-the-human-body-a-histological-and-electron-microscopic-study
#6
Martin Boháč, Ľuboš Danišovič, Ján Koller, Jana Dragúňová, Ivan Varga
Acellular matrices are used for various purposes and they have been studied extensively for their potential roles in regenerating tissues or organs. The acellular matrix generates physiological cues that mimic the native tissue microenvironment. Acellular dermal matrix (ADM) is a soft connective tissue graft generated by a decellularization process that preserves the intact extracellular skin matrix. Upon implantation, this structure serves as a scaffold for donor-side cells to facilitate subsequent incorporation and revascularization...
January 22, 2018: European Journal of Histochemistry: EJH
https://www.readbyqxmd.com/read/29554482/transcutaneous-implantation-of-valproic-acid-encapsulated-dissolving-microneedles-induces-hair-regrowth
#7
Shayan Fakhraei Lahiji, Seol Hwa Seo, Suyong Kim, Manita Dangol, Jiyong Shim, Cheng Guo Li, Yonghao Ma, Chisong Lee, Geonwoo Kang, Huisuk Yang, Kang-Yell Choi, Hyungil Jung
The interest in alternative material systems and delivery methods for treatment of androgenetic alopecia has been increasing in the recent decades. Topical application of valproic acid (VPA), an FDA-approved anticonvulsant drug, has been shown to effectively stimulate hair follicle (HF) regrowth by upregulating Wnt/β-catenin, a key pathway involved in initiation of HF development. Moreover, a majority of studies have suggested that cutaneous wound re-epithelialization is capable of inducing HF through Wnt/β-catenin pathway...
June 2018: Biomaterials
https://www.readbyqxmd.com/read/29546437/rippling-following-breast-augmentation-or-reconstruction-aetiology-emerging-treatment-options-and-a-novel-classification-of-severity
#8
REVIEW
Nicholas M Pantelides, Jeyaram R Srinivasan
BACKGROUND: Implant rippling is a frequent complication following breast augmentation or implant-based reconstruction and results in significant patient dissatisfaction. Traditionally, the treatment has been to replace the implant, often placing it in a subpectoral pocket to reduce the risk of recurrence. Other techniques, such as increasing the implant size or tightening the capsule, can also be used. Recently, however, there has been much interest in alternative treatments, including fat grafting or insertion of an acellular dermal matrix...
March 15, 2018: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/29505164/enoxaparin-does-not-affect-network-formation-of-adipose-tissue-derived-microvascular-fragments
#9
Thomas Später, Florian S Frueh, Philipp Karschnia, Michael D Menger, Matthias W Laschke
Dermal substitutes are frequently used for the initial coverage of extensive skin defects. The seeding of these implants with adipose tissue-derived microvascular fragments (ad-MVF) has recently been shown to accelerate their vascularization and incorporation. In the present study we analyzed whether these processes are affected by a thromboprophylactic therapy with the low molecular weight heparin (LMWH) enoxaparin (enox). Green fluorescent protein (GFP)+ ad-MVF were isolated from enox- (8 mg/kg s.c.) and vehicle-treated (0...
March 5, 2018: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/29498444/innovations-and-advancements-with-prosthetic-breast-reconstruction
#10
Maurice Y Nahabedian
Prosthetic breast reconstruction has evolved over the years to provide results that now mimic that of a natural breast. This is due to a variety of innovations and advancements related to mastectomy techniques, acellular dermal matrices, autologous fat grafting, and improved breast implants. The evolution of prosthetic breast reconstruction has gone full-circle and included prepectoral placement in the 1970s and 80s, partial or total subpectoral placement from 1985 to 2015, and now gradually trending back to prepectoral...
March 2, 2018: Breast Journal
https://www.readbyqxmd.com/read/29493250/preservation-of-natural-gingival-pigmentation-when-treating-multiple-gingival-recession-defects
#11
Douglas H Mahn
Proper surgical techniques can permit treatment of multiple gingival recession defects without altering the visible gingival pigmentation. In this case report, a patient presented with multiple adjacent sites displaying gingival recession. Natural pigmentation was present in the interdental papillae and in the zone of keratinized gingiva. This patient wanted his natural pigmentation to be preserved. A modified tunnel technique was used to avoid traumatizing the pigmented tissues and allow placement of a large graft...
March 2018: Compendium of Continuing Education in Dentistry
https://www.readbyqxmd.com/read/29489547/complications-after-two-stage-expander-implant-breast-reconstruction-requiring-reoperation-a-critical-analysis-of-outcomes
#12
Gloria R Sue, Beatrice J Sun, Gordon K Lee
BACKGROUND: Two-stage expander implant breast reconstruction is commonly performed after mastectomy. Salvage and long-term outcomes after development of complications have not been well described. We examined a single surgeon's experience to study the rate of reoperation secondary to complications after first-stage expander placement and to evaluate their outcomes. Better understanding of salvage techniques may help guide future management. METHODS: We performed a retrospective analysis of consecutive patients who underwent placement of a tissue expander (TE) for breast reconstruction between December 2006 and August 2015 with the senior author...
May 2018: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29481482/evaluation-of-contralateral-and-bilateral-prophylactic-mastectomy-and-reconstruction-outcomes-comparing-alloplastic-and-autologous-reconstruction
#13
Patrick Bletsis, Alexandra Bucknor, Anmol Chattha, Parisa Kamali, Austin Chen, Renata Flecha-Hirsch, Berend van der Lei, Bernard T Lee, Samuel J Lin
BACKGROUND: Over the last decade, there has been a 12% increase in prophylactic mastectomy (PM) per year. The aim of the study was to analyze complication rates and associated risk factors in patients undergoing PM and reconstruction. METHODS: We reviewed patients undergoing PM (contralateral and bilateral) from 2010 to 2015 at a single academic institution. Data on patient characteristics and postoperative outcomes were obtained. Postoperative complications were categorized into minor and major groups...
February 23, 2018: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29481386/evaluation-of-acellular-dermal-matrix-efficacy-in-prosthesis-based-breast-reconstruction
#14
Nikhil Sobti, Emily Ji, Rebecca L Brown, Curtis L Cetrulo, Amy S Colwell, Jonathan M Winograd, William G Austen, Eric C Liao
BACKGROUND: Although many studies have examined the safety of acellular dermal matrix in immediate prosthetic breast reconstruction, few studies have evaluated efficacy. This study examined initial tissue expander fill volume as a marker of efficacy, comparing patients after staged prosthetic breast reconstruction assisted with acellular dermal matrix versus breast reconstruction not assisted with acellular dermal matrix. Number of fill visits and time interval to implant exchange were examined as secondary endpoints...
March 2018: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29473493/current-limitations-in-the-treatment-parkinson-s-and-alzheimer-s-diseases-state-of-the-art-and-future-perspective-of-polymeric-carriers
#15
Chiara Tonda-Turo, Nicola Origlia, Clara Mattu, Alice Accorroni, Valeria Chiono
Alzheimer's and Parkinson's disease are the most common neurodegenerative diseases worldwide and their incidence is increasing due to the aging population. At the moment, the available therapies are not disease modifying and have several limitations, some of which are discussed in this review. One of the main limitations of these treatments is the low concentration that drugs reach in the central nervous system after systemic administration. Indeed, the presence of biological barriers, particularly the blood brain barrier (BBB), hinders the effective drug delivery to the brain, reducing the potential benefit coming from the administration of the medication...
February 21, 2018: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/29464161/complications-following-nipple-sparing-mastectomy-and-immediate-acellular-dermal-matrix-implant-based-breast-reconstruction-a-systematic-review-and-meta-analysis
#16
Lene Nyhøj Heidemann, Gudjon L Gunnarsson, C Andrew Salzberg, Jens Ahm Sørensen, Jørn Bo Thomsen
Background: Acellular dermal matrix was introduced in breast reconstruction in 2001 and is gradually becoming a standard component for immediate breast reconstruction and nipple-sparing mastectomy. The reconstructive technique allows for improved aesthetic outcomes. However, there seems to be uncertainty regarding complication rates. The aim of this review was to systematically evaluate complication rates related to this method. Methods: This systematic review was conducted according to the recommendations outlined in the Cochrane Handbook for reviews and reported in line with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement...
January 2018: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/29464155/single-stage-breast-reconstruction-using-an-all-in-one-adjustable-expander-implant
#17
Alain J Azzi, Dino Zammit, Lucie Lessard
Background: When tissue expansion is necessary in breast reconstruction, a single-stage approach is possible using adjustable expander/implants, with or without the use of acellular dermal matrix. We aimed to present the senior author's single-stage experience over a period of 12 years using combined expander/implants in breast reconstruction. Methods: This is a Single-institution, retrospective review of breast reconstruction with combined expander/implants from 2002 to 2014...
January 2018: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/29450975/tropoelastin-implants-that-accelerate-wound-repair
#18
Suzanne M Mithieux, Behnaz Aghaei-Ghareh-Bolagh, Leping Yan, Kekini V Kuppan, Yiwei Wang, Francia Garces-Suarez, Zhe Li, Peter K Maitz, Elizabeth A Carter, Christina Limantoro, Wojciech Chrzanowski, David Cookson, Alan Riboldi-Tunnicliffe, Clair Baldock, Kosuke Ohgo, Kristin K Kumashiro, Glenn Edwards, Anthony S Weiss
A novel, pure, synthetic material is presented that promotes the repair of full-thickness skin wounds. The active component is tropoelastin and leverages its ability to promote new blood vessel formation and its cell recruiting properties to accelerate wound repair. Key to the technology is the use of a novel heat-based, stabilized form of human tropoelastin which allows for tunable resorption. This implantable material contributes a tailored insert that can be shaped to the wound bed, where it hydrates to form a conformable protein hydrogel...
February 16, 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29449959/sulfobetaine-methacrylate-hydrogel-coated-anti-fouling-surfaces-for-implantable-biomedical-devices
#19
Se Yeong Lee, Yunki Lee, Phuong Le Thi, Dong Hwan Oh, Ki Dong Park
Background: Zwitterionic molecules have been widely studied as coating materials for preparing anti-fouling surfaces because they possess strong hydration properties that can resist non-specific protein adsorption. Numerous studies on surface modification using zwitterionic molecules have been investigated, such as electrochemically mediated and photoinitiated radical polymerization. However, these methods have some limitations, including multi-step process, difficulties in producing thick and dense layers as well as the requirement of extra facilities...
2018: Biomaterials Research
https://www.readbyqxmd.com/read/29434662/novel-devices-for-implant-based-breast-reconstruction-is-the-use-of-meshes-to-support-the-lower-pole-justified-in-terms-of-benefits-a-review-of-the-evidence
#20
REVIEW
Lorna Jane Cook, Tibor Kovacs
The use of novel devices such as acellular dermal matrices (ADMs) to support the lower pole in implant-based breast reconstructions (IBBRs) has been described as one of the most important advances in breast reconstructive surgery following mastectomy. However, the majority of outcomes studies focus primarily on providing evidence for the rates of short-term complications associated with their use, as opposed to their reported benefits. Given the high costs associated with using ADMs, together with an increasing number of alternative, cheaper synthetic products entering the market, it is important to clarify whether their use is actually justified and whether the alternative products offer equivalent or superior outcomes...
2018: Ecancermedicalscience
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