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Dermal Implants

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https://www.readbyqxmd.com/read/27911032/a-dermal-equivalent-engineered-with-tgf-%C3%AE-3-expressing-bone-marrow-stromal-cells-and-amniotic-membrane-cosmetic-healing-of-full-thickness-skin-wounds-in-rats
#1
Ali Samadikuchaksaraei, Ahmad Mehdipour, Mehryar Habibi Roudkenar, Javad Verdi, Mohammad Taghi Joghataei, Kamran As'adi, Fatemeh Amiri, Mozhgan Dehghan Harati, Mazaher Gholipourmalekabadi, Nushin Karkuki Osguei
Transforming growth factor beta-3 (TGF-β3) has been shown to decrease scar formation after scheduled topical applications to the cutaneous wounds. This study aimed to continuously deliver TGF-β3, during the early phase of wound healing, by engineering a dermal equivalent (DE) using TGF-β3 expressing bone marrow stromal cells (BM-SCs) and human dehydrated amniotic membrane (hDAM). To engineer a DE, rat BM-SCs were seeded on the hDAM and TGF-β3 was transiently transfected into the BM-SCs using a plasmid vector...
December 2016: Artificial Organs
https://www.readbyqxmd.com/read/27904691/implantation-of-placenta-derived-mesenchymal-stem-cells-accelerates-murine-dermal-wound-closure-through-immunomodulation
#2
Haifeng Wang, Lianyu Chen, Yang Liu, Bangzhen Luo, Nanzi Xie, Tao Tan, Lige Song, Pei Erli, Ming Luo
BACKGROUND: Diabetic foot ulcer (DFU) is a major complication of diabetes mellitus. Although previous studies have established that inflammation, ischemia and neuropathy contribute to the development of DFU, it is still an unmet medical need due to lack knowledge of cellular and molecular mechanisms associated with DFU. In the present study, we tested our hypothesis that subcutaneous application of human placental mesenchymal stem cells (PMSCs) can accelerate diabetic dermal wound healing by modulating immunoresponse...
2016: American Journal of Translational Research
https://www.readbyqxmd.com/read/27896182/the-effect-of-sterile-acellular-dermal-matrix-use-on-complication-rates-in-implant-based-immediate-breast-reconstructions
#3
Jun Ho Lee, Youngsoo Park, Kyoung Wook Choi, Kyu-Jin Chung, Tae Gon Kim, Yong-Ha Kim
BACKGROUND: The use of acellular dermal matrix (ADM) in implant-based immediate breast reconstruction has been increasing. The current ADMs available for breast reconstruction are offered as aseptic or sterile. No published studies have compared aseptic and sterile ADM in implant-based immediate breast reconstruction. The authors performed a retrospective study to evaluate the outcomes of aseptic versus sterile ADM in implant-based immediate breast reconstruction. METHODS: Implant-based immediate breast reconstructions with ADM conducted between April 2013 and January 2016 were included...
November 2016: Archives of Plastic Surgery
https://www.readbyqxmd.com/read/27878067/ultrasonography-findings-of-alloderm-%C3%A2-used-in-postmastectomy-alloplastic-breast-reconstruction-a-case-report-and-literature-review
#4
Young Seon Kim
AlloDerm(®) (LifeCell Corp.; Brancburg, NJ) is an acellular dermal matrix (ADM) that serves as an immunologically inert scaffold in plastic surgery. In breast reconstruction, it is used as a filler for lumpectomy defects and can be used to create the inferolateral portion of the tissue expander pocket or implant pocket in postmastectomy patients. However, there are limited reports of the radiologic findings of AlloDerm(®) in patients who have undergone postmastectomy reconstruction. Familiarity with the imaging features of AlloDerm(®) is essential for correct diagnosis...
July 2016: Iranian Journal of Radiology: a Quarterly Journal Published By the Iranian Radiological Society
https://www.readbyqxmd.com/read/27869543/direct-bonding-of-chitosan-biomaterials-to-tissues-using-transglutaminase-for-surgical-repair-or-device-implantation
#5
Javier Fernandez, Suneil Seetharam, Christopher Ding, Edward Doherty, Donald Ingber
Natural biomaterials, such as chitosan and collagen, are useful for biomedical applications because they are biocompatible, mechanically robust and biodegradable, but it is difficult to rapidly and tightly bond them to living tissues. Here, we demonstrate that the microbial enzyme transglutaminase (mTG) can be used to rapidly (< 5 min) bond chitosan and collagen biomaterials to the surfaces of hepatic, cardiac and dermal tissues, as well as to functionalized polydimethylsiloxane (PDMS) materials that are used in medical products...
November 21, 2016: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/27862914/in-vivo-biocompatibility-vascularization-and-incorporation-of-integra-%C3%A2-dermal-regenerative-template-and-flowable-wound-matrix
#6
Thomas Später, Florian S Frueh, Wolfgang Metzger, Michael D Menger, Matthias W Laschke
Integra(®) matrix wound dressing (MWD) is used for the reconstruction of full-thickness skin defects. For the treatment of complex wounds, this dermal substitute is available as a flowable wound matrix (FWM) of identical composition. To clarify whether variations in sample preparation and consistency affect the biocompatibility and tissue incorporation, we herein compared MWD and FWM. The matrices were characterized using scanning electron microscopy and histology. Moreover, they were implanted in mouse dorsal skinfold chambers to analyze their in vivo performance over 2 weeks...
November 14, 2016: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/27836404/randomized-controlled-trial-of-octyl-cyanoacrylate-skin-adhesive-versus-subcuticular-suture-for-skin-closure-after-implantable-venous-port-placement
#7
Jonathan G Martin, Scott T Hollenbeck, Gemini Janas, Ryan A Makar, Waleska M Pabon-Ramos, Paul V Suhocki, Michael J Miller, David R Sopko, Tony P Smith, Charles Y Kim
PURPOSE: To compare early outcomes of skin closure with octyl cyanoacrylate skin adhesive versus subcuticular suture closure. MATERIALS AND METHODS: Over a 7-month period, 109 subjects (28 men and 81 women; mean age, 58.6 y) scheduled to undergo single-lumen implantable venous port insertion for chemotherapy were randomly assigned to skin closure with either octyl cyanoacrylate skin adhesive or absorbable subcuticular suture after suturing the deep dermal layer...
November 8, 2016: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/27834419/limitations-and-options-using-resorbable-versus-nonresorbable-membranes-for-successful-guided-bone-regeneration
#8
Nikolaos K Soldatos, Popi Stylianou, Vasiliki P Koidou, Nikola Angelov, Raymond Yukna, Georgios E Romanos
OBJECTIVE: Deficient bony ridges often complicate the implant treatment plan. Several treatment modalities are used to regenerate bone, including guided bone regeneration (GBR). The purpose of this study was to summarize the knowledge on different types of membranes available and currently used in GBR procedures in a staged approach or with simultaneous implant placement. The primary role of the membranes is to exclude epithelial and connective tissue cells from the wound area to be regenerated, and to create and maintain the space into which pluripotential and osteogenic cells are free to migrate...
November 10, 2016: Quintessence International
https://www.readbyqxmd.com/read/27830734/vegf-released-by-deferoxamine-preconditioned-mesenchymal-stem-cells-seeded-on-collagen-gag-substrates-enhances-neovascularization
#9
Elizabeth A Wahl, Thilo L Schenck, Hans-Günther Machens, Elizabeth R Balmayor
Hypoxia preconditioning of mesenchymal stem cells (MSCs) has been shown to promote wound healing through HIF-1α stabilization. Preconditioned MSCs can be applied to three-dimensional biomaterials to further enhance the regenerative properties. While environmentally induced hypoxia has proven difficult in clinical settings, this study compares the wound healing capabilities of adipose derived (Ad) MSCs seeded on a collagen-glycosaminoglycan (GAG) dermal substrate exposed to either environmental hypoxia or FDA approved deferoxamine mesylate (DFO) to stabilize HIF-1α for wound healing...
November 10, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27825422/use-of-acellular-dermal-matrices-in-one-stage-implant-based-breast-reconstruction
#10
Jian-Yu Dong, Yan Yan, Min-Feng Liu, Zhao-Ze Guo, Jing-Yun Guo, Chang-Sheng Ye
Implant-based breast reconstruction is the most common choice in breast cancer patients. Recently,the acellular dermal matrix (ADM) technique has been widely used in implant-based breast reconstruction in the western countries. This article briefly reviews the biological characteristics,history,types,surgical techniques,and postoperative complications of ADM.
October 10, 2016: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
https://www.readbyqxmd.com/read/27822035/biofunctionalization-of-silicone-rubber-with-microgroove-patterned-surface-and-carbon-ion-implantation-to-enhance-biocompatibility-and-reduce-capsule-formation
#11
Ze-Yuan Lei, Ting Liu, Wei-Juan Li, Xiao-Hua Shi, Dong-Li Fan
PURPOSE: Silicone rubber implants have been widely used to repair soft tissue defects and deformities. However, poor biocompatibility can elicit capsule formation, usually resulting in prosthesis contracture and displacement in long-term usage. To overcome this problem, this study investigated the properties of silicone rubber materials with or without a microgroove-patterned surface and with or without carbon (C)-ion implantation. MATERIALS AND METHODS: Atomic force microscopy, X-ray photoelectron spectroscopy, and a water contact angle test were used to characterize surface morphology and physicochemical properties...
2016: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/27811481/dose-and-time-dependent-cellular-effects-of-cold-atmospheric-pressure-plasma-evaluated-in-3d-skin-models
#12
Cornelia Wiegand, Sarah Fink, Oliver Beier, Kerstin Horn, Andreas Pfuch, Arnd Schimanski, Bernd Grünler, Uta-Christina Hipler, Peter Elsner
BACKGROUND: Application of cold atmospheric pressure plasmas (CAPs) in or on the human body was termed 'plasma medicine'. So far, plasmas were utilized for sterilization of implants, other heat-sensitive products, or employed for chemical surface modifications. By now, CAPs are further used effectively for wound treatment. The present study analyses the effect of a plasma jet with air or nitrogen as process gas, previously evaluated for antimicrobial efficacy, on human cells using a 3D skin model...
November 4, 2016: Skin Pharmacology and Physiology
https://www.readbyqxmd.com/read/27800186/modified-lower-pole-autologous-dermal-sling-for-implant-reconstruction-in-women-undergoing-immediate-breast-reconstruction-after-mastectomy
#13
Pankaj G Roy
Background. Autologous dermal sling with wise pattern skin reducing mastectomy allows one-stage implant reconstruction in women with large and ptotic breasts needing mastectomy for cancer or risk reduction. However, this technique is not suitable for women who lack ptosis and also carries risk of T-junction breakdown. Method. We have performed one-stage nipple sparing mastectomies with implant reconstruction in 5 women (8 breasts) by modifying the autologous dermal sling approach. All these women had small to moderate breasts with no ptosis or pseudoptosis...
2016: International Journal of Breast Cancer
https://www.readbyqxmd.com/read/27787951/the-superiority-of-the-autografts-inactivated-by-high-hydrostatic-pressure-to-decellularized-allografts-in-a-porcine-model
#14
Naoki Morimoto, Atsushi Mahara, Chizuru Jinno, Mami Ogawa, Natsuko Kakudo, Shigehiko Suzuki, Toshia Fujisato, Kenji Kusumoto, Tetsuji Yamaoka
We are developing a novel skin regeneration therapy in which the inactivation of nevus tissue via high hydrostatic pressure (HHP) is used in the reconstruction of the dermis in combination with a cultured epidermal autograft. In this study, we used a porcine skin graft model to explore whether autologous skin including cellular debris inactivated by HHP or allogeneic skin decellularized by HHP is better for dermal reconstruction. Grafts (n = 6) were prepared for five groups each: autologous skin without pressurization group (control group), autologous skin inactivated by 200 MPa group, autologous skin inactivated by 1000 MPa group, allogeneic skin decellularized by 200 MPa group, and allogeneic skin decellularized by 1000 MPa group...
October 27, 2016: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/27782996/comparison-of-antibiotic-coated-versus-uncoated-porcine-dermal-matrix
#15
Leslie E Cohen, Thomas A Imahiyerobo, Jeffrey R Scott, Jason A Spector
BACKGROUND: The objective of this study was to evaluate the antimicrobial performance of a rifampin/minocycline-coated, non-cross-linked, acellular porcine dermal matrix (XenMatrix AB) compared to an uncoated, non-cross-linked, acellular porcine dermal matrix (Strattice) after implantation/inoculation with methicillin-resistant Staphylococcus aureus or Escherichia coli in a dorsal rabbit model. METHODS: Forty male New Zealand White rabbits were bilaterally implanted with XenMatrix AB or Strattice grafts and inoculated with clinically isolated methicillin-resistant S...
November 2016: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/27782982/surgeon-controlled-study-and-meta-analysis-comparing-flexhd-and-alloderm-in-immediate-breast-reconstruction-outcomes
#16
Nikhil Sobti, Eric C Liao
BACKGROUND: The use of acellular dermal matrix has facilitated immediate prosthesis-based breast reconstruction. However, few studies directly compare surgical outcomes following acellular dermal matrix-based reconstruction with two of the most commonly available materials, AlloDerm and FlexHD. Those studies that are available often do not adequately control for the surgeon as a variable. The authors hypothesize that complication rates will not differ significantly between AlloDerm and FlexHD when practice and surgeon variables are properly controlled...
November 2016: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/27770576/improved-pocket-control-in-immediate-microsurgical-breast-reconstruction-with-simultaneous-implant-placement-through-the-use-of-mesh
#17
Arash Momeni, Suhail K Kanchwala
BACKGROUND: Autologous breast reconstruction is associated with long-term patient satisfaction that is superior to implant-based approaches. Occasionally, however, patients who desire autologous reconstruction present with inadequate donor-site volume. A hybrid approach, combining free flap reconstruction with simultaneous implant placement, is a solution. We present our experience with the use of mesh for improved pocket control using this reconstructive modality. METHODS: A retrospective analysis of a prospectively maintained database of patients undergoing autologous breast reconstruction was performed...
October 22, 2016: Microsurgery
https://www.readbyqxmd.com/read/27763970/evaluation-of-the-biocompatibility-of-new-fiber-reinforced-composite-materials-for-craniofacial-bone-reconstruction
#18
Mădălina-Anca Lazar, Horaţiu Rotaru, Ioana Bâldea, Adina B Boşca, Cristian P Berce, Cristina Prejmerean, Doina Prodan, Radu S Câmpian
This study aims to assess the biocompatibility of new advanced fiber-reinforced composites (FRC) to be used for custom-made cranial implants. Four new formulations of FRC were obtained using polymeric matrices (combinations of monomers bisphenol A glycidylmethacrylate [bis-GMA], urethane dimethacrylate [UDMA], triethylene glycol dimethacrylate [TEGDMA], hydroxyethyl methacrylate [HEMA]) and E-glass fibers (300 g/mp). Every FRC contains 65% E-glass and 35% polymeric matrix. Composition of polymeric matrices are: bis-GMA (21%), TEGDMA (14%) for FRC1; bis-GMA (21%), HEMA (14%) for FRC2; bis-GMA (3...
October 2016: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/27755446/augmentation-rhinoplasty-with-silicone-implant-covered-with-acellular-dermal-matrix
#19
Man Koon Suh, Kyo Ho Lee, Aram Harijan, Hyung-Gu Kim, Euicheol C Jeong
BACKGROUND: Alloplastic materials are a mainstay in Asian rhinoplasty. However, the outline of alloplastic implants can become conspicuous over time in rhinoplasty patients, which is a significant cause for revision. In revision rhinoplasty, alloplastic materials can remain a viable and affordable option in Asian patients. The acellular dermal matrices (ADM) are often used to interface between the silicone material and the skin envelope. This study assesses histologic changes following implantation of ADM-covered silicone material in rats...
October 14, 2016: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/27744069/model-polymer-system-for-investigating-the-generation-of-hydrogen-peroxide-and-its-biological-responses-during-the-crosslinking-of-mussel-adhesive-moiety
#20
Hao Meng, Yuan Liu, Bruce P Lee
: Mussel adhesive moiety, catechol, has been utilized to design a wide variety of biomaterials. However, the biocompatibility and biological responses associated with the byproducts generated during the curing process of catechol has never been characterized. An in situ curable polymer model system, 4-armed polyethylene glycol polymer end-capped with dopamine (PEG-D4), was used to characterize the production of hydrogen peroxide (H2O2) during the oxidative crosslinking of catechol. Although PEG-D4 cured rapidly (under 30s), catechol continues to polymerize over several hours to form a more densely crosslinked network over time...
October 12, 2016: Acta Biomaterialia
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