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Myocardial infraction

Hossein Yousefi-Banaem, Saeed Kermani, Sasan Asiaei, Hamid Sanei
Myocardial infarction is a leading cause of morbidity and mortality. In this study, using Cine MRI images, the infarct region was precisely determined by examining the local migration path length of critical points on myocardium borders and the fractional thickening effects. First, MRI Cine images of Epi/Endocardium were processed in 3D for all slices, and then incorporated in all frames to build a dynamic model. Epi/Endocardium images were segmented using Heiberg algorithm, and then by a robust restricted block matching algorithm, the sparse points were tracked...
November 14, 2016: Computers in Biology and Medicine
Xiao Qiang Xie, Pei Zhang, Bo Tian, Xiao Qian Chen
Sirtuin 2 (SIRT2) is a member of NAD(+)-dependent protein deacetylases involved in a wide range of pathophysiological processes including myocardial injury, Parkinson's disease, and Huntington's disease. However, the direct implication of SIRT2 in ischemic stroke is still unclear. In the present study, we observed that SIRT2 protein was mainly expressed in the cytoplasm of neurons, but not in astrocyte and microglia. SIRT2 was upregulated in ischemic neurons in the oxygen-glucose deprivation cell model and in the transient middle cerebral artery occlusion (tMCAo) mouse model...
October 29, 2016: Molecular Neurobiology
Fazhong He, Mouze Liu, Zhangren Chen, Guojing Liu, Zhenmin Wang, Rong Liu, Jianquan Luo, Jie Tang, Xingyu Wang, Xin Liu, Honghao Zhou, Xiaoping Chen, Zhaoqian Liu, Wei Zhang
Effects of human tribbles homolog 3 (TRIB3) genetic variation (c.251 A>G, Gln84Arg, rs2295490) on the clinical outcomes of vascular events has not been evaluated in patients with type 2 diabetes after blood pressure lowering and glucose controlling treatment. We did an analysis of a 2×2 factorial (glucose control axis and blood pressure lowering axis) randomized controlled clinical trial at 61 centers in China, with a follow-up period of 5years. The major vascular endpoints were the composites of death from cardio-cerebral vascular diseases, non-fatal stroke and myocardial infraction, new or worsening renal and diabetic eye disease...
October 20, 2016: EBioMedicine
Da-Qing Jiang, Tian-Xiang Gu, Zhao-Fa Xu, Shuang Liu, Xue-Yuan Li
OBJECTIVE: To investigate whether heart tissue-derived extracellular matrix (ECM) promotes the differentiation of cardiosphere-derived cells (CDCs) implanted in rat infracted myocardium to improve the cardiac structure and function. METHODS: Rat CDCs were cultured by cardiac explant methods, and ECM was prepared by decelluariztion method. In a Wistar rat model of acute myocardial infarction established by ligating the left anterior descending branch, IMDM solution, ECM suspension, 10(6) CDCs in IMDM solution, or 10(6) CDCs in ECM suspension were injected into the infracted rat myocardium (6 rats in each group)...
October 20, 2016: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
Safa Yaghini Bonabi, Fatima El-Hamad, Alexander Müller, Michael Dommasch, Alexander Steger, Georg Schmidt, Mathias Baumert
Beat-to-beat variability of the QT interval (QTV) measured on surface ECG has emerged as a potential marker for ventricular repolarization instability and has been used along with heart rate variability (HRV) to predict arrhythmic risk. Since measurement modalities of QTV have not been standardized, the objective of this study was to investigate the effect of ECG recording duration on QTV as well as HRV. Using a database of 30 min ECG recorded from 500 patients with acute myocardial infraction during rest, we extracted RR and QT interval time series and estimated different HRV and QTV metrics over windows of varying length...
September 28, 2016: Physiological Measurement
Soraya Taleb
Atherosclerosis is an inflammatory disease within the arterial wall that is responsible for several important adverse vascular events, including coronary artery disease, myocardial infraction, stroke and peripheral artery disease. Both innate and adaptive immunity play important roles in the development of atherosclerosis. In particular, monocytes/macrophages, which are the surrogate cells of innate immunity, have important proatherogenic effects. In addition, adaptive immune responses effected by T cells play important roles in atherosclerosis...
August 29, 2016: Archives of Cardiovascular Diseases
Wojciech Wanha, Damian Kawecki, Tomasz Roleder, Aleksandra Pluta, Kamil Marcinkiewicz, Beata Morawiec, Mariusz Kret, Tomasz Pawlowski, Grzegorz Smolka, Andrzej Ochala, Wojciech Wojakowski
BACKGROUND: The aim of this study was to evaluate gender differences in the long-term clinical outcomes and safety of patients treated with first- and second-generation DES. METHODS: The Katowice-Zabrze Registry included 1916 consecutive patients treated with either first or second-generation DES. We evaluated major adverse cardiac and cerebral events (MACCE) [composite of death, myocardial infarction (MI), stroke and target vessel revascularization (TVR)] at 12-month follow-up...
July 29, 2016: Scandinavian Cardiovascular Journal: SCJ
F J García-Soidán, R Villoro, M Merino, Á Hidalgo-Vega, T Hernando-Martín, B González-Martín-Moro
INTRODUCTION: This study analyses the health status of patients diagnosed with diabetes mellitus (DM), their health related quality of life (HRQoL) and their use of healthcare resources in Spain. MATERIALS AND METHODS: A descriptive analysis was conducted using the Spanish Health National Survey (ENSE, 2012), gathering data on those patients aged 15 and over diagnosed with DM. Their health status, their HRQoL, and their use of healthcare resources were systematically compared with those of patients diagnosed with other chronic conditions (OCC), as well as a population without DM (non-DM)...
July 18, 2016: Semergen
Sheetal Kashinath Medhekar, Vikas Suresh Shende, Anjali Baburao Chincholkar
Stem cells are primitive self renewing undifferentiated cell that can be differentiated into various types of specialized cells like nerve cell, skin cells, muscle cells, intestinal tissue, and blood cells. Stem cells live in bone marrow where they divide to make new blood cells and produces peripheral stem cells in circulation. Under proper environment and in presence of signaling molecules stem cells begin to develop into specialized tissues and organs. These unique characteristics make them very promising entities for regeneration of damaged tissue...
May 30, 2016: International Journal of Stem Cells
Peng Lu, Yi-Qian Zhang, Hao Zhang, Yu-Feng Li, Xiao-Yu Wang, Hao Xu, Zhi-Wei Liu, Lei Li, Hong-Yan Dong, Zhong-Ming Zhang
BACKGROUND: Pigment epithelium-derived factor (PEDF), which belongs to the noninhibitory serpin family, has shown the ability to stimulate several physiological processes, such as antiangiogenesis, anti-inflammation, and antioxidation. In the present study, the effects of PEDF on contractility and calcium handling of rat ventricular myocytes were investigated. METHODS AND RESULTS: Adult Sprague-Dawley rat models of acute myocardial infarction (AMI) were surgically established...
July 2016: Journal of the American Heart Association
Hisashi Sato, Yoshihiro Nakayama, Hideya Tanaka, Baku Takahashi
We report a rare case of ventricular septal perforation (VSP) after inferior myocardial infarction. Surgical repair of VSP after inferior infarction is technically difficult because of its anatomical location. An 81-year-old female presented with dyspnea on the 8th day after percutaneous coronary intervention for acute inferior myocardial infarction. Echocardiography revealed a ventricular septal perforation. Urgent operation was performed. There was a VSP around the base of the ventricular septum. The myocardial infarction extended to the adjacent muscle of the mitral valve annulus...
July 2016: Kyobu Geka. the Japanese Journal of Thoracic Surgery
Tadashi Hoshino, Kazuma Hanai, Kazuhito Tanimoto, Tomohiro Nakayama
BACKGROUND: The diagnosis of myocardial infraction (MI) in patients presenting to the emergency department represents a clinical challenge. It is known that creatine kinase-MB isoenzyme (CK-MB) is present in soluble cell fractions of cardiac muscle, and injury to those cells results in an increase of CK-MB in the blood. Therefore, CK-MB is a suitable clinical biomarker of myocardial infraction. METHODS: To measure CK-MB mass rapidly and easily, we developed the new reagent 'L-type Wako CK-MB mass' (L-CK-MB mass) for the latex agglutination turbidimetric immunoassay method...
2016: Clinical Laboratory
Tuo Liang, Yuhui Zhang, Shijie Yin, Tianyi Gan, Tao An, Rongcheng Zhang, Yunhong Wang, Yan Huang, Qiong Zhou, Jian Zhang
BACKGROUND: Qiliqiangxin (QL) capsule is a traditional Chinese medicine which has been approved for the treatment of chronic heart failure. Evidences proved that QL capsules further reduced the NT-proBNP levels and improved left ventricular ejection fraction in CHF patients but the evidence supporting its underlying mechanism is still unclear. METHODS AND RESULTS: Myocardial infarction (MI) -Heart failure (HF) Sprague-Dawley ratsmodel and neonatal rat cardiac myocytes (NRCMs) were used...
2016: American Journal of Translational Research
Gino A Kurian, Rashmi Rajagopal, Srinivasan Vedantham, Mohanraj Rajesh
Oxidative and reductive stress are dual dynamic phases experienced by the cells undergoing adaptation towards endogenous or exogenous noxious stimulus. The former arises due to the imbalance between the reactive oxygen species production and antioxidant defenses, while the latter is due to the aberrant increase in the reducing equivalents. Mitochondrial malfunction is the common denominator arising from the aberrant functioning of the rheostat that maintains the homeostasis between oxidative and reductive stress...
2016: Oxidative Medicine and Cellular Longevity
Melissa Lyle, Ryan C Van Woerkom, Marysia Tweet, Phillip M Young, Patricia J M Best
Acute ST elevation in the anterior precordial leads typically suggests an anteroseptal infarction due to left anterior descending coronary artery obstruction, but the differential can be broad. Conus branch artery occlusion is a potentially overlooked cause of anteroseptal ST elevation myocardial infraction. Cardiac magnetic resonance (CMR) imaging is an emerging technology which can differentiate the etiology of anterior ST elevation in patients with no apparent coronary abnormalities on coronary angiography and normal echocardiography...
June 2016: Cardiovascular Diagnosis and Therapy
Yu B Lishmanov, L N Maslov, A V Mukhomedzyanov
We studied the effects of β-adrenoceptor antagonists propranolol and nadolol and L-type Ca(2+)-channel blocker verapamil on cardiac reperfusion injury developed after 45-min coronary occlusion. The substances were injected intravenously 5 min before reperfusion. The results indicate that activation of β-adrenoceptors and opening of L-type Ca(2+)-channels promote the development of cardiac reperfusion injury, while blockage of β-adrenoceptors and/or L-type Ca(2+)-channels prevents reoxygenation-induced myocardial injury...
May 2016: Bulletin of Experimental Biology and Medicine
Jayant Shankar Raut, Sankunny Mohan Karuppayil, Maria Gazouli, Manolis Vavuranakis, Gerasimos Siasos, Theodoros Zografos, Evangelos Oikonomou, Dimitris Vrachatis, Konstantinos Kalogeras, Theodoros Papaioannou, Michail-Aggelos Kolokathis, Carmen Moldovan, Dimitrios Tousoulis
BACKGROUND: Transcatheter aortic valve implantation (TAVI) has undeniably earned a prestigious post in the quiver of interventional cardiologists against symptomatic severe aortic stenosis. Cerebrovascular events are listed within the most frequent complications. METHODS: We performed a systematic search of EMBASE, MEDLINE, and the Cochrane library from inception to March 2016 for the following search terms (transcatheter AND antiplatelet) OR (transcatheter AND antithrombotic) to retrieve studies of dual antiplatelet treatment (DAPT) and single antiplatelet treatment (SAPT) in patients after TAVI to study thrombotic, hemorrhagic and cardiovascular events at 30 days post procedure...
June 1, 2016: Current Pharmaceutical Design
Sandeep Grover, K Suchendra, Aseem Mehra, Vijay Parkash, Vikas Saini, Shiv Bagga
There is limited literature on the use of electroconvulsive therapy (ECT) in patients with recent myocardial infarction and in those with reduced cardiac output. In this report, we describe the safe use of ECT in a 70-year-male suffering from severe depressive episode with psychotic symptoms. He had a history of poor response to adequate pharmacotherapy and had suffered from myocardial infraction (MI), about 3 weeks prior to admission to the psychiatric unit. In view of severe depression associated with marked anxiety, agitation, psychotic symptoms, and poor food intake he was started on ECT after 5 weeks of MI when his cardiac output was only 30%...
July 2015: Industrial Psychiatry Journal
Jiunn-Yih Wu, Meng-Tse Gabriel Lee, Si-Huei Lee, Shih-Hao Lee, Yi-Wen Tsai, Shou-Chien Hsu, Shy-Shin Chang, Chien-Chang Lee
Numerous epidemiological data suggest that the use of angiotensin-converting enzyme inhibitors (ACEis) can improve the clinical outcomes of pneumonia. Tuberculosis (TB) is an airborne bacteria like pneumonia, and we aimed to find out whether the use of ACEis can decrease the risk of active TB.We conducted a nested case-control analysis by using a 1 million longitudinally followed cohort, from Taiwan national health insurance research database. The rate ratios (RRs) for TB were estimated by conditional logistic regression, and adjusted using a TB-specific disease risk score (DRS) with 71 TB-related covariates...
May 2016: Medicine (Baltimore)
Haidong Wang, Xi Li, Wenting Zhang, Yao Liu, Shijun Wang, Xiaoquan Liu, Hua He
1. Salvianolic acid A (SalA) was found to attenuate plasma uric acid (UA) concentration and xanthine oxidase (XO) activity in acute myocardial infraction (AMI) rats, which was characterized with developed mechanism-based pharmacokinetic-pharmacodynamic (PK-PD) model. 2. AMI was induced in rats by coronary artery ligation. Surviving AMI rats received a single intravenous dose of 5 mg/kg of SalA and normal saline. The plasma SalA concentrations were determined by HPLC-MS/MS method. The plasma UA concentrations were determined by HPLC method and plasma XO activity were measured spectrophotometrically...
May 11, 2016: Xenobiotica; the Fate of Foreign Compounds in Biological Systems
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