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Myocardial infraction

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https://www.readbyqxmd.com/read/28065766/changes-in-one-year-mortality-in-elderly-patients-admitted-with-acute-myocardial-infarction-in-relation-with-early-management
#1
Etienne Puymirat, Nadia Aissaoui, Guillaume Cayla, Alexandre Lafont, Elisabeth Riant, Marco Mennuni, Olivier Saint-Jean, Didier Blanchard, Patrick Jourdain, Meyer Elbaz, Patrick Henry, Vincent Bataille, Elodie Drouet, Geneviève Mulak, François Schiele, Jean Ferrières, Tabassome Simon, Nicolas Danchin
BACKGROUND: Elderly patients are underrepresented in acute myocardial infarction trials. Our aim was to determine whether, in elderly patients, changes in management in the past 15 years is associated with improved one-year mortality after hospital admission for myocardial infarction. METHODS: We used data from 4 one-month French registries, conducted 5 years apart from 1995 to 2010, including 3,389 elderly patients (≥75 years). RESULTS: From 1995 to 2010, mean age remained stable (82...
January 5, 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/27971828/measuring-the-relationship-between-hospital-costs-and-quality-of-care-an-example-of-acute-myocardial-infraction-in-edmonton-alberta-canada
#2
F Chu, A Ohinmaa, P Kaul
No abstract text is available yet for this article.
November 2016: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/27968888/health-insurance-and-quality-and-efficiency-of-medical-care-for-patients-with-acute-myocardial-infraction-in-tertiary-hospitals-in-shanxi-china-a-retrospective-study
#3
Xiao Jun Lin, Hong Bing Tao, Miao Cai, Zhao Hui Cheng, Man Li Wang, Chang Xu, Hai Feng Lin, Li Jin
BACKGROUND: Previous studies have shown that health insurance type affects patient outcomes, but empirical research on the effect of health insurance on quality and efficiency of care in China is scarce. This study aimed to determine whether there are health insurance-related differences in hospital care for acute myocardial infraction. METHODS: Patients with a principal diagnosis of acute myocardial infraction were identified from inpatient discharge records of 27 tertiary hospitals in Shanxi, China from September 1, 2013, to October 31, 2014...
October 2016: Lancet
https://www.readbyqxmd.com/read/27956911/association-between-latest-activated-sites-in-the-left-ventricle-and-akinetic-segments-in-patients-with-ischemic-cardiomyopathy
#4
Hakimeh Sadeghian, Aliasghar Kousari, Shahla Majidi, Mehrnaz Rezvanfard, Ali Kazemisaeid, Seyed Ali Moezzi, Ali Vasheghani Farahani, Morteza Abdar Esfahani, Mohammad Sahebjam, Arezoo Zoroufian, Afsaneh Sadeghian
Background: It is not clear whether the latest activation sites in the left ventricle (LV) are matched with infracted regions in patients with ischemic cardiomyopathy (ICM). We aimed to investigate whether the latest activation sites in the LV are in agreement with the region of akinesia in patients with ICM. Methods: Data were analyzed in 106 patients (age = 60.5 ± 12.1 y, male = 88.7%) with ICM (ejection fraction ≤ 35%) who were refractory to pharmacological therapy and were referred to the echocardiography department for an evaluation of the feasibility of cardiac resynchronization therapy...
July 6, 2016: Journal of Tehran Heart Center
https://www.readbyqxmd.com/read/27940923/prognostic-value-of-an-increase-in-post-exercise-ankle-brachial-index
#5
Tarek A Hammad, William R Hiatt, Heather L Gornik, Mehdi H Shishehbor
Prior studies have assessed the prognostic value of a decrease, not an increase, of the post-exercise ankle-brachial index (ABI) among patients with normal resting results. Thus, we sought to evaluate the prognostic significance of an increase in post-exercise ABI among these patients. From a single center vascular laboratory database between September 2005 and January 2010, we retrospectively identified 1437 consecutive patients with a normal resting ABI (1.00-1.40) and available post-exercise results. We classified them into group 1 (normal subjects; post-exercise ABI drop ⩽ 20%, 58%) and group 2 (post-exercise ABI increase, 42%) after excluding those with an ABI drop > 20% (peripheral artery disease) as they had known disease (n=192)...
December 9, 2016: Vascular Medicine
https://www.readbyqxmd.com/read/27893992/prediction-of-myocardial-infarction-by-assessing-regional-cardiac-wall-in-cmr-images-through-active-mesh-modeling
#6
Hossein Yousefi-Banaem, Saeed Kermani, Sasan Asiaei, Hamid Sanei
Myocardial infarction is a leading cause of morbidity and mortality. In this study, using Cine MRI images, the infarct region was precisely determined by examining the local migration path length of critical points on myocardium borders and the fractional thickening effects. First, MRI Cine images of Epi/Endocardium were processed in 3D for all slices, and then incorporated in all frames to build a dynamic model. Epi/Endocardium images were segmented using Heiberg algorithm, and then by a robust restricted block matching algorithm, the sparse points were tracked...
November 14, 2016: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/27796760/downregulation-of-nad-dependent-deacetylase-sirt2-protects-mouse-brain-against-ischemic-stroke
#7
Xiao Qiang Xie, Pei Zhang, Bo Tian, Xiao Qian Chen
Sirtuin 2 (SIRT2) is a member of NAD(+)-dependent protein deacetylases involved in a wide range of pathophysiological processes including myocardial injury, Parkinson's disease, and Huntington's disease. However, the direct implication of SIRT2 in ischemic stroke is still unclear. In the present study, we observed that SIRT2 protein was mainly expressed in the cytoplasm of neurons, but not in astrocyte and microglia. SIRT2 was upregulated in ischemic neurons in the oxygen-glucose deprivation cell model and in the transient middle cerebral artery occlusion (tMCAo) mouse model...
October 29, 2016: Molecular Neurobiology
https://www.readbyqxmd.com/read/27793583/assessment-of-human-tribbles-homolog-3-genetic-variation-rs2295490-effects-on-type-2-diabetes-patients-with-glucose-control-and-blood-pressure-lowering-treatment
#8
Fazhong He, Mouze Liu, Zhangren Chen, Guojing Liu, Zhenmin Wang, Rong Liu, Jianquan Luo, Jie Tang, Xingyu Wang, Xin Liu, Honghao Zhou, Xiaoping Chen, Zhaoqian Liu, Wei Zhang
Effects of human tribbles homolog 3 (TRIB3) genetic variation (c.251 A>G, Gln84Arg, rs2295490) on the clinical outcomes of vascular events has not been evaluated in patients with type 2 diabetes after blood pressure lowering and glucose controlling treatment. We did an analysis of a 2×2 factorial (glucose control axis and blood pressure lowering axis) randomized controlled clinical trial at 61 centers in China, with a follow-up period of 5years. The major vascular endpoints were the composites of death from cardio-cerebral vascular diseases, non-fatal stroke and myocardial infraction, new or worsening renal and diabetic eye disease...
November 2016: EBioMedicine
https://www.readbyqxmd.com/read/27777191/-effect-of-implantation-of-cardiosphere-derived-cells-combined-with-rat-heart-tissue-derived-extracellular-matrix-on-acute-myocardial-infarction-in-rats
#9
Da-Qing Jiang, Tian-Xiang Gu, Zhao-Fa Xu, Shuang Liu, Xue-Yuan Li
OBJECTIVE: To investigate whether heart tissue-derived extracellular matrix (ECM) promotes the differentiation of cardiosphere-derived cells (CDCs) implanted in rat infracted myocardium to improve the cardiac structure and function. METHODS: Rat CDCs were cultured by cardiac explant methods, and ECM was prepared by decelluariztion method. In a Wistar rat model of acute myocardial infarction established by ligating the left anterior descending branch, IMDM solution, ECM suspension, 10(6) CDCs in IMDM solution, or 10(6) CDCs in ECM suspension were injected into the infracted rat myocardium (6 rats in each group)...
October 20, 2016: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/27681306/recording-duration-and-short-term-reproducibility-of-heart-rate-and-qt-interval-variability-in-patients-with-myocardial-infarction
#10
Safa Yaghini Bonabi, Fatima El-Hamad, Alexander Müller, Michael Dommasch, Alexander Steger, Georg Schmidt, Mathias Baumert
Beat-to-beat variability of the QT interval (QTV) measured on surface ECG has emerged as a potential marker for ventricular repolarization instability and has been used along with heart rate variability (HRV) to predict arrhythmic risk. Since measurement modalities of QTV have not been standardized, the objective of this study was to investigate the effect of ECG recording duration on QTV as well as HRV. Using a database of 30 min ECG recorded from 500 patients with acute myocardial infraction during rest, we extracted RR and QT interval time series and estimated different HRV and QTV metrics over windows of varying length...
September 28, 2016: Physiological Measurement
https://www.readbyqxmd.com/read/27595467/inflammation-in-atherosclerosis
#11
REVIEW
Soraya Taleb
Atherosclerosis is an inflammatory disease within the arterial wall that is responsible for several important adverse vascular events, including coronary artery disease, myocardial infraction, stroke and peripheral artery disease. Both innate and adaptive immunity play important roles in the development of atherosclerosis. In particular, monocytes/macrophages, which are the surrogate cells of innate immunity, have important proatherogenic effects. In addition, adaptive immune responses effected by T cells play important roles in atherosclerosis...
December 2016: Archives of Cardiovascular Diseases
https://www.readbyqxmd.com/read/27471987/gender-differences-and-bleeding-complications-after-pci-on-first-and-second-generation-des
#12
Wojciech Wanha, Damian Kawecki, Tomasz Roleder, Aleksandra Pluta, Kamil Marcinkiewicz, Beata Morawiec, Mariusz Kret, Tomasz Pawlowski, Grzegorz Smolka, Andrzej Ochala, Wojciech Wojakowski
BACKGROUND: The aim of this study was to evaluate gender differences in the long-term clinical outcomes and safety of patients treated with first- and second generation DES. METHODS: The Katowice-Zabrze Registry included 1916 consecutive patients treated with either first or second generation DES. We evaluated major adverse cardiac and cerebrovascular events (MACCE) [composite of death, myocardial infarction (MI), stroke and target vessel revascularization (TVR)] at 12-month follow-up...
February 2017: Scandinavian Cardiovascular Journal: SCJ
https://www.readbyqxmd.com/read/27445223/-health-status-quality-of-life-and-use-of-healthcare-resources-by-patients-with-diabetes-mellitus-in-spain
#13
F J García-Soidán, R Villoro, M Merino, Á Hidalgo-Vega, T Hernando-Martín, B González-Martín-Moro
INTRODUCTION: This study analyses the health status of patients diagnosed with diabetes mellitus (DM), their health related quality of life (HRQoL) and their use of healthcare resources in Spain. MATERIALS AND METHODS: A descriptive analysis was conducted using the Spanish Health National Survey (ENSE, 2012), gathering data on those patients aged 15 and over diagnosed with DM. Their health status, their HRQoL, and their use of healthcare resources were systematically compared with those of patients diagnosed with other chronic conditions (OCC), as well as a population without DM (non-DM)...
July 18, 2016: Semergen
https://www.readbyqxmd.com/read/27426082/recent-stem-cell-advances-cord-blood-and-induced-pluripotent-stem-cell-for-cardiac-regeneration-a-review
#14
REVIEW
Sheetal Kashinath Medhekar, Vikas Suresh Shende, Anjali Baburao Chincholkar
Stem cells are primitive self renewing undifferentiated cell that can be differentiated into various types of specialized cells like nerve cell, skin cells, muscle cells, intestinal tissue, and blood cells. Stem cells live in bone marrow where they divide to make new blood cells and produces peripheral stem cells in circulation. Under proper environment and in presence of signaling molecules stem cells begin to develop into specialized tissues and organs. These unique characteristics make them very promising entities for regeneration of damaged tissue...
May 30, 2016: International Journal of Stem Cells
https://www.readbyqxmd.com/read/27413044/pigment-epithelium-derived-factor-pedf-improves-ischemic-cardiac-functional-reserve-through-decreasing-hypoxic-cardiomyocyte-contractility-through-pedf-receptor-pedf-r
#15
Peng Lu, Yi-Qian Zhang, Hao Zhang, Yu-Feng Li, Xiao-Yu Wang, Hao Xu, Zhi-Wei Liu, Lei Li, Hong-Yan Dong, Zhong-Ming Zhang
BACKGROUND: Pigment epithelium-derived factor (PEDF), which belongs to the noninhibitory serpin family, has shown the ability to stimulate several physiological processes, such as antiangiogenesis, anti-inflammation, and antioxidation. In the present study, the effects of PEDF on contractility and calcium handling of rat ventricular myocytes were investigated. METHODS AND RESULTS: Adult Sprague-Dawley rat models of acute myocardial infarction (AMI) were surgically established...
July 2016: Journal of the American Heart Association
https://www.readbyqxmd.com/read/27365060/-ventricular-septal-perforation-after-inferior-myocardial-infarction
#16
Hisashi Sato, Yoshihiro Nakayama, Hideya Tanaka, Baku Takahashi
We report a rare case of ventricular septal perforation (VSP) after inferior myocardial infarction. Surgical repair of VSP after inferior infarction is technically difficult because of its anatomical location. An 81-year-old female presented with dyspnea on the 8th day after percutaneous coronary intervention for acute inferior myocardial infarction. Echocardiography revealed a ventricular septal perforation. Urgent operation was performed. There was a VSP around the base of the ventricular septum. The myocardial infarction extended to the adjacent muscle of the mitral valve annulus...
July 2016: Kyobu Geka. the Japanese Journal of Thoracic Surgery
https://www.readbyqxmd.com/read/27349014/development-and-evaluation-of-a-new-creatine-kinase-mb-mass-determination-assay-using-a-latex-agglutination-turbidimetric-immunoassay-with-an-automated-analyzer
#17
Tadashi Hoshino, Kazuma Hanai, Kazuhito Tanimoto, Tomohiro Nakayama
BACKGROUND: The diagnosis of myocardial infraction (MI) in patients presenting to the emergency department represents a clinical challenge. It is known that creatine kinase-MB isoenzyme (CK-MB) is present in soluble cell fractions of cardiac muscle, and injury to those cells results in an increase of CK-MB in the blood. Therefore, CK-MB is a suitable clinical biomarker of myocardial infraction. METHODS: To measure CK-MB mass rapidly and easily, we developed the new reagent 'L-type Wako CK-MB mass' (L-CK-MB mass) for the latex agglutination turbidimetric immunoassay method...
2016: Clinical Laboratory
https://www.readbyqxmd.com/read/27347313/cardio-protecteffect-of-qiliqiangxin-capsule-on-left-ventricular-remodeling-dysfunction-and-apoptosis-in-heart-failure-rats-after-chronic-myocardial-infarction
#18
Tuo Liang, Yuhui Zhang, Shijie Yin, Tianyi Gan, Tao An, Rongcheng Zhang, Yunhong Wang, Yan Huang, Qiong Zhou, Jian Zhang
BACKGROUND: Qiliqiangxin (QL) capsule is a traditional Chinese medicine which has been approved for the treatment of chronic heart failure. Evidences proved that QL capsules further reduced the NT-proBNP levels and improved left ventricular ejection fraction in CHF patients but the evidence supporting its underlying mechanism is still unclear. METHODS AND RESULTS: Myocardial infarction (MI) -Heart failure (HF) Sprague-Dawley ratsmodel and neonatal rat cardiac myocytes (NRCMs) were used...
2016: American Journal of Translational Research
https://www.readbyqxmd.com/read/27313825/the-role-of-oxidative-stress-in-myocardial-ischemia-and-reperfusion-injury-and-remodeling-revisited
#19
REVIEW
Gino A Kurian, Rashmi Rajagopal, Srinivasan Vedantham, Mohanraj Rajesh
Oxidative and reductive stress are dual dynamic phases experienced by the cells undergoing adaptation towards endogenous or exogenous noxious stimulus. The former arises due to the imbalance between the reactive oxygen species production and antioxidant defenses, while the latter is due to the aberrant increase in the reducing equivalents. Mitochondrial malfunction is the common denominator arising from the aberrant functioning of the rheostat that maintains the homeostasis between oxidative and reductive stress...
2016: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/27280090/conus-artery-occlusion-causing-isolated-right-ventricular-outflow-tract-infarction-novel-application-of-cardiac-magnetic-resonance-in-anterior-stemi
#20
Melissa Lyle, Ryan C Van Woerkom, Marysia Tweet, Phillip M Young, Patricia J M Best
Acute ST elevation in the anterior precordial leads typically suggests an anteroseptal infarction due to left anterior descending coronary artery obstruction, but the differential can be broad. Conus branch artery occlusion is a potentially overlooked cause of anteroseptal ST elevation myocardial infraction. Cardiac magnetic resonance (CMR) imaging is an emerging technology which can differentiate the etiology of anterior ST elevation in patients with no apparent coronary abnormalities on coronary angiography and normal echocardiography...
June 2016: Cardiovascular Diagnosis and Therapy
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