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https://www.readbyqxmd.com/read/29150926/viral-short-orfs-and-their-possible-functions
#1
REVIEW
Yaara Finkel, Noam Stern-Ginossar, Michal Schwartz
Definition of functional genomic elements is one of the greater challenges of the genomic era. Traditionally, putative short Open Reading Frames (sORFs) coding for less than 100 amino acids were disregarded due to computational and experimental limitations, however it has become clear over the past several years that translation of sORFs is pervasive and serves diverse functions. The development of ribosome profiling, allowing identification of translated sequences genome-wide, revealed wide-spread, previously unidentified translation events...
November 18, 2017: Proteomics
https://www.readbyqxmd.com/read/29150540/increased-florbetapir-binding-in-the-temporal-neocortex-from-age-20-to-60-years
#2
Julie Gonneaud, Eider M Arenaza-Urquijo, Florence Mézenge, Brigitte Landeau, Malo Gaubert, Alexandre Bejanin, Robin de Flores, Miranka Wirth, Clémence Tomadesso, Géraldine Poisnel, Ahmed Abbas, Béatrice Desgranges, Gaël Chételat
OBJECTIVE: To improve our understanding of early β-amyloid (Aβ) accumulation processes using florbetapir-PET scan in 20- to 60-year-old individuals. METHODS: Seventy-six cognitively normal individuals aged 20 to 60 years, 57 cognitively normal older individuals (61-84 years old), and 70 patients with mild cognitive impairment or probable Alzheimer disease (AD) underwent a florbetapir-PET scan. Images were spatially normalized and scaled using the whole cerebellum...
November 17, 2017: Neurology
https://www.readbyqxmd.com/read/29150536/availability-sales-and-affordability-of-tobacco-cessation-medicines-in-kerala-india
#3
Smitha Sarma, Sivadasanpillai Harikrishnan, Abigail S Baldridge, Raji Devarajan, Aashna Mehta, Sakhtivel Selvaraj, Mohammed K Ali, Padinhare P Mohanan, Dorairaj Prabhakaran, Mark D Huffman
BACKGROUND: India is the world's second largest consumer of tobacco, but tobacco cessation remains uncommon due, at least in part, to underutilization of cessation pharmacotherapy. We evaluated the availability, sales, and affordability of nicotine replacement therapy, bupropion, and varenicline in the South Indian state of Kerala to understand potential reasons for underutilization. METHODS AND RESULTS: From November 2016 to April 2017, we collected data on availability, inventory, and pricing of cessation medication through a cross-sectional survey of 199 public, semiprivate (Karunya), and private pharmacies across 5 districts in Kerala using World Health Organization/Health Action International methodology...
November 2017: Circulation. Cardiovascular Quality and Outcomes
https://www.readbyqxmd.com/read/29150326/concomitant-mitral-valve-procedures-in-patients-undergoing-implantation-of-continuous-flow-left-ventricular-assist-devices-an-intermacs-database-analysis
#4
Jason O Robertson, David C Naftel, Susan L Myers, Ryan J Tedford, Susan M Joseph, James K Kirklin, Scott C Silvestry
BACKGROUND: Management of existing mitral valve (MV) disease in patients undergoing left ventricular assist device (LVAD) implantation remains controversial. METHODS: Among continuous-flow LVAD patients with moderate to severe mitral regurgitation entered into the Interagency Registry for Mechanically Assisted Circulatory Support (INTERMACS) database between April 2008 and March 2014 (n = 4,930), outcomes were compared between patients who underwent MV repair (MVr, n = 252), MV replacement (MVR, n = 11) and no MV procedure (no MVP, n = 4,667)...
October 10, 2017: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/29150156/the-efficacy-of-danshen-injection-as-adjunctive-therapy-in-treating-angina-pectoris-a-systematic-review-and-meta-analysis
#5
REVIEW
Huikai Shao, Mengsi Li, Fuchao Chen, Lianghua Chen, Zhengjin Jiang, Lingguo Zhao
BACKGROUND: During the last 40 years, Danshen injection has been widely used as an adjunctive therapy for angina pectoris in China, but its efficacy is not yet well defined. The objective of this study was to verify the efficacy of Danshen injection as adjunctive therapy in treating angina pectoris. METHODS: The major databases including PubMed, Cochrane Library, Sino-Med, Medline, Embase, Google Scholar, China National Knowledge Infrastructure, Wanfang Databases, Chinese Scientific Journal Database, Chinese Biomedical Literature Database and the Chinese Science Citation Database were systematically searched for the published randomised controlled trials (RCTs) on Danshen injection until April 2016...
November 6, 2017: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/29150145/neuroimaging-biomarkers-as-predictors-of-treatment-outcome-in-major-depressive-disorder
#6
REVIEW
Trehani M Fonseka, Glenda M MacQueen, Sidney H Kennedy
BACKGROUND: Current practice for selecting pharmacological and non-pharmacological antidepressant treatments has yielded low response and remission rates in Major Depressive Disorder (MDD). Neuroimaging biomarkers of brain structure and function may be useful in guiding treatment selection by predicting response vs. non-response outcomes. METHODS: In this review, we summarize data from studies examining predictors of treatment response using structural and functional neuroimaging modalities, as they pertain to pharmacotherapy, psychotherapy, and stimulation treatment strategies...
October 31, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29149881/how-effective-are-interventions-to-improve-social-outcomes-among-offenders-with-personality-disorder-a-systematic-review
#7
Catriona Connell, Vivek Furtado, Elizabeth A McKay, Swaran P Singh
BACKGROUND: Offenders with personality disorder are supported by health, criminal justice, social care and third sector services. These services are tasked with reducing risk, improving health and improving social outcomes. Research has been conducted into interventions that reduce risk or improve health. However, interventions to improve social outcomes are less clearly defined. METHODS: To review the effectiveness of interventions to improve social outcomes we conducted a systematic review using Cochrane methodology, expanded to include non-randomised trials...
November 17, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/29149797/findings-from-a-strength-based-moderate-intensity-exercise-interventions-for-individuals-with-dementia-innovative-practice
#8
Nicole Dawson, Hayden Gerhart, Katherine S Judge
Limited evidence exists regarding exercise interventions with individuals with dementia, which is often due to heterogeneity of methodology and outcomes being assessed. This led to the development and evaluation of a moderate-intensity home-based functional exercise program guided by theories from exercise science and the Strength-Based Approach. Data indicated excellent treatment adherence (99.04%) along with high levels of acceptability and feasibility in this sample (age 76.63 years (9.84); Mini Mental State Exam 18...
January 1, 2017: Dementia
https://www.readbyqxmd.com/read/29149507/registered-nurse-and-midwife-experiences-of-using-videoconferencing-in-practice-a-systematic-review-of-qualitative-studies
#9
REVIEW
Robyn A Penny, Natalie K Bradford, Danette Langbecker
AIM: To synthesise evidence of registered nurses' and midwives' experiences with videoconferencing and identify perceptions of the appropriateness, meaningfulness and feasibility of this technology in professional and clinical practice. BACKGROUND: Videoconferencing is a form of telehealth that can facilitate access to high quality care to improve health outcomes for patients and enable clinicians working in isolation to access education, clinical supervision, peer support and case review...
November 17, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/29148963/clinical-stroke-research-in-resource-limited-settings-tips-and-hints
#10
Jeyaraj D Pandian, Hueiming Liu, Dorcas Bc Gandhi, Richard I Lindley
Background Most stroke research is conducted in high income countries, yet most stroke occurs in low- and middle-income countries. There is an urgent need to build stroke research capacity in low- and middle-income countries. Aims To review the global health literature on how to improve research capacity in low- and middle-income countries, provide additional data from the recently completed ATTEND Trial and provide examples from our own experience. Summary of review The main themes from our literature review were: manpower and workload, research training, research question and methodology and research funding...
January 1, 2017: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/29148629/carbohydrate-mouth-rinse-improves-cycling-performance-carried-out-until-the-volitional-exhaustion
#11
Bruno Bavaresco Gambassi, Ylana Gomes de Santana Barros Leal, Edson R Pinheiro Dos Anjos, Bruna A Antonelli, Daniela C Gomes Gonçalves E Silva, Iracema H Pires de Mélo Montenegro, Rita di Cássia de Oliveira Angelo, Isis S Correia Moura, Paulo A Schwingel
BACKGROUND: Carbohydrates (CHO) are among the most investigated nutritional ergogenic aids, and may be consumed in different forms, e.g., mouth rinse with carbohydrate solution (MRCS). In this sense, the aim of this study was to evaluate the impact of MRCS on the performance of physically active individuals undergoing a physical exercise session carried out until the volitional exhaustion. METHODS: This is a counter-balanced randomized study, with a double-blind design...
November 17, 2017: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/29148566/factors-that-influence-the-provision-of-intrapartum-and-postnatal-care-by-skilled-birth-attendants-in-low-and-middle-income-countries-a-qualitative-evidence-synthesis
#12
REVIEW
Susan Munabi-Babigumira, Claire Glenton, Simon Lewin, Atle Fretheim, Harriet Nabudere
BACKGROUND: In many low- and middle-income countries women are encouraged to give birth in clinics and hospitals so that they can receive care from skilled birth attendants. A skilled birth attendant (SBA) is a health worker such as a midwife, doctor, or nurse who is trained to manage normal pregnancy and childbirth. (S)he is also trained to identify, manage, and refer any health problems that arise for mother and baby. The skills, attitudes and behaviour of SBAs, and the extent to which they work in an enabling working environment, impact on the quality of care provided...
November 17, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29148259/vasovagal-reactions-in-blood-donors-risks-prevention-and-management
#13
REVIEW
A Thijsen, B Masser
This narrative review examines current research on risk factors, prevention methods and management strategies for vasovagal reactions (VVRs) that occur during or as a result of blood donation. VVRs are important to blood collection agencies (BCAs) as they negatively impact the number of completed collections, perceptions of the safety of blood donation and rates of donor return. There has been significant progress in understanding and preventing VVRs in blood donation in recent years, with a multitude of risk factors identified...
November 16, 2017: Transfusion Medicine
https://www.readbyqxmd.com/read/29148106/epidemiology-of-donors-and-recipients-lessons-from-the-scandat-database
#14
REVIEW
G Edgren, H Hjalgrim
With the development of several 'vein-to-vein' databases, which capture data on the entire donor-recipient continuum and link this data to health outcomes, there has been an increasing number of studies investigating the health effects of all aspects of the practice of transfusion medicine. The Scandinavian Donations and Transfusions (SCANDAT) database is one of several such databases, which includes all electronically available data on blood donors, donations and transfusions since the late 1960s in Sweden and the early 1980s in Denmark...
November 16, 2017: Transfusion Medicine
https://www.readbyqxmd.com/read/29147982/opportunity-mapping-of-natural-flood-management-measures-a-case-study-from-the-headwaters-of-the-warwickshire-avon
#15
Tom Lavers, Susanne Charlesworth
The use of natural flood management (NFM) measures to address severe flooding received considerable public attention during December 2015-January 2016 storms. Within the Warwickshire-Avon Catchment, UK, high arable and improved grassland land cover with small, isolated communities at risk, lead to the exploration of novel techniques that use farmland high up in flood-prone catchments to hold water and reduce outflow discharge. This paper will discuss the methodology used to identify areas in the Warwickshire-Avon, which could be used to install NFM measures to attenuate the storm peak and provide wider ecosystem services, principally addressing total phosphate and sediment entering the receiving watercourse...
November 16, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29147758/a-systematic-review-assessing-non-pharmacological-conservative-treatment-studies-for-people-with-non-inflammatory-multi-joint-pain-clinical-outcomes-and-research-design-considerations
#16
REVIEW
C Comer, T O Smith, B Drew, R Raja, S R Kingsbury, Philip G Conaghan
To systematically review the evidence to determine the clinical outcomes and the important methodological quality features of interventional studies on adults with non-inflammatory multi-joint pain (MJP). Systematic search of published and unpublished literature using the databases: AMED, CINAHL, MEDLINE, EMBASE, psycINFO, SPORTDiscus, PEDro, OpenGrey, the EU Clinical Trials Register, World Health Organization International Clinical Trial Registry Platform, ClinicalTrials.gov and the ISRCTN registry (search: inception to 19th October 2017)...
November 16, 2017: Rheumatology International
https://www.readbyqxmd.com/read/29147026/leveraging-genome-characteristics-to-improve-gene-discovery-for-putamen-subcortical-brain-structure
#17
Chi-Hua Chen, Yunpeng Wang, Min-Tzu Lo, Andrew Schork, Chun-Chieh Fan, Dominic Holland, Karolina Kauppi, Olav B Smeland, Srdjan Djurovic, Nilotpal Sanyal, Derrek P Hibar, Paul M Thompson, Wesley K Thompson, Ole A Andreassen, Anders M Dale
Discovering genetic variants associated with human brain structures is an on-going effort. The ENIGMA consortium conducted genome-wide association studies (GWAS) with standard multi-study analytical methodology and identified several significant single nucleotide polymorphisms (SNPs). Here we employ a novel analytical approach that incorporates functional genome annotations (e.g., exon or 5'UTR), total linkage disequilibrium (LD) scores and heterozygosity to construct enrichment scores for improved identification of relevant SNPs...
November 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29146397/temporal-evolution-of-the-environmental-performance-of-implementing-selective-collection-in-municipal-waste-management-systems-in-developing-countries-a-brazilian-case-study
#18
Valeria Ibáñez-Forés, María D Bovea, Claudia Coutinho-Nóbrega, Hozana R de Medeiros-García, Raissa Barreto-Lins
The aim of this study is to analyse the evolution of the municipal solid waste management system of João Pessoa (Brazil), which was one of the Brazilian pioneers cities in implementing door-to-door selective collection programmes, in order to analyse the effect of policy decisions adopted in last decade with regard to selective collection. To do it, this study focuses on analysing the evolution, from 2005 to 2015, of the environmental performance of the municipal solid waste management (MSWM) system implemented in different sorting units with selective collection programmes by applying the Life Cycle Assessment (LCA) methodology and using as a starting point data collected directly from the different stakeholders involved in the MSWM system...
November 13, 2017: Waste Management
https://www.readbyqxmd.com/read/29145806/computer-and-telephone-delivered-interventions-to-support-caregivers-of-people-with-dementia-a-systematic-review-of-research-output-and-quality
#19
Amy Waller, Sophie Dilworth, Elise Mansfield, Rob Sanson-Fisher
BACKGROUND: To assess the scope, volume and quality of research on the acceptability, utilisation and effectiveness of telephone- and computer-delivered interventions for caregivers of people living with dementia. METHODS: Medline, EMBASE, CINAHL and Cochrane databases were searched (Jan 1990 - Dec 2016). Eligible papers were classified as data-based descriptive, measurement or intervention studies. Intervention studies were first categorised according to mode of delivery (e...
November 16, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/29145529/volumetric-bone-measurement-around-dental-implants-using-3d-image-superimposition-a-methodological-and-clinical-pilot-study
#20
Eduardo Aydos Villarinho, André Correia, Alvaro Vigo, Nuno Viriato Ramos, Mário Augusto Pires Vaz, Rosemary Sadami Arai Shinkai
PURPOSE: This study describes the development of a methodology for using three-dimensional (3D) image superimposition to measure volumetric changes in bone level around dental implants in comparison with linear measures. MATERIALS AND METHODS: The sample was comprised of 46 dental implants of 6-mm length and 4.1-mm diameter placed in the posterior maxilla and posterior mandible in 20 patients. All implants received screw-retained single crowns. Radiographic images were taken using cone beam computed tomography (CBCT) and digital periapical radiography after implantation and after 12 and 24 months of functional loading (after crown installation)...
November 16, 2017: International Journal of Prosthodontics
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