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AdCC diet

Takanori Maruyama, Kousaku Mimura, Shinichiro Izawa, Shugo Shiba, Mitsuaki Watanabe, Yoshihiko Kawaguchi, Hideki Fujii, Koji Kono
OBJECTIVE: Although randomized clinical trials have shown that immunonutrition results in the improvement of postoperative complications, the detailed mechanisms of its immunomodulation are still unclear. In the present study, we investigated if such immunonutrition could affect T-cell and natural killer (NK) cell functions, with particular focus on type 17 helper T (Th17) cells and NK cell-activating markers, in patients with esophageal and gastric cancer and in healthy volunteers. METHODS: Patients (n = 22) and healthy volunteers (n = 10) were orally administered an immunonutritional diet (Impact, 750 mL/d) in addition to a conventional diet for 5 d...
February 2011: Nutrition
Wardhana, E A Datau
Recurrent Aphthous Stomatitis (RAS) is one of the most common oral lesions which occur either in single or multiple forms in oral mucosa. The mouth is subjected to a wide spectrum of antigenic agents, including foodstuff, and allergic reactions to such antigens may manifest in a number of diverse ways. Food allergy, however, has not been widely investigated as the cause of RAS. The main complaint of RAS typically is pain, and the main therapy is still corticosteroids, besides avoiding allergenic foodstuff. In RAS, there is often a genetic basis...
October 2010: Acta Medica Indonesiana
M De la Fuente, M D Ferrández, M Del Rio, M Sol Burgos, J Miquel
Previous research has shown that supplementation of the diet with thioproline (thiazolidine-4-carboxylic acid), an intracellular sulfhydryl antioxidant and free radical scavenger, increases mouse life span and stimulates the immune system. In the present study aged Swiss mice (20 month old) fed thioproline (0.07%,w/w) for 5 weeks were used. Twelve month and 20 month old mice fed standard diet were used as controls. The lymphoproliferative response to the mitogen Concanavalin A (Con A) and the mobility of lymphocytes, both spontaneous and directed to a chemoattractant gradient (chemotaxis), as well as antibody-dependent cellular cytotoxicity (ADCC) and natural killer (NK) activity of leukocytes, were measured in cells from spleen and thymus...
September 1, 1998: Mechanisms of Ageing and Development
T S Lim, N Putt, D Safranski, C Chung, R R Watson
A high vitamin E diet altered cell-mediated immune responses of maturing BALB/c mice. Serum corticosterone concentrations in these animals were also determined because of the pharmacological effect the glucocorticoid hormone has on immune systems. Mice receiving high vitamin E diet (twenty times higher than the vitamin E concentration in control diet) showed significant increase in antibody-dependent cellular cytotoxicity (ADCC) activity within a week after initiation of the diet. Adult levels of spleen and intestinal ADCC activities were reached at a much younger age in these high vitamin E-treated animals...
October 1981: Immunology
R K Chandra, B Au
The thymus of rats provided zinc-deficient diet weighed less than the thymus of animals fed zinc-containing control diet. The antibody-forming cell response in the spleen was reduced. Cytotoxic response of spleen cells of zinc-deficient mice immunized in vivo was decreased whereas after sensitization in vitro the response was comparable to that seen in zinc-replete animals. Natural killer cell activity and antibody-dependent cell-mediated cytotoxicity were increased, particularly the former. These observations suggest that dietary zinc intake is an important factor modulating cell-mediated immune responses...
April 1980: American Journal of Clinical Nutrition
T S Lim, N Messiha, R R Watson
The studies were designed to investigate the effect of ageing and low protein (4%) diet on antibody-dependent cell-mediated cytotoxicity (ADCC) and IgA concentration in the intestine. Both ADCC activity and IgA concentration were shown to reach mature levels at 17 weeks old. The effect of ageing was greater on ADCC activity which showed a drastic drop in activity at 75 weeks old than IgA which had only a slight decline in concentration at this age. The low protein diet has a greater suppressive effect on IgA concentration than on ADCC activity...
July 1981: Immunology
H C Meeker, M L Eskew, W Scheuchenzuber, R W Scholz, A Zarkower
Experiments were performed to determine the effects of dietary selenium and/or vitamin E deficiency on cell-mediated cytotoxicity in the mouse. Natural killer cell-mediated cytotoxicity (NKCC) was depressed after 8 wk on diets deficient in selenium and/or vitamin E. In contrast, antibody-dependent cell-mediated cytotoxicity (ADCC) was not affected by 8 wk of dietary deficiency of selenium and/or vitamin E. T-lymphocyte-mediated cytotoxicity (TCMC) was found to be depressed by combined selenium-vitamin E deficiency after 7 weeks on diets...
October 1985: Journal of Leukocyte Biology
M L Eskew, W J Scheuchenzuber, R W Scholz, C C Reddy, A Zarkower
Deficiencies in vitamin E (E) or Se result in immune alterations, possibly due to reduction of antioxidant activity. Such reductions might greatly compromise the ability of the immune system to deal with additional oxidant stress, as encountered during exposure to air pollutants such as ozone (O3). To study possible interactions of these oxidative stresses on immune function, male Long-Evans hooded rats were maintained 5 weeks on torula yeast-based diets, with or without the addition of E or Se. Each dietary group was subdivided into O3-exposed and nonexposed groups...
August 1986: Environmental Research
M Lessard, W C Yang, G S Elliott, A H Rebar, J F Van Vleet, N Deslauriers, G J Brisson, R D Schultz
The effects of dietary restriction of vitamin E (Vit E) and selenium (Se) on lymphocyte proliferation, natural killer (NK) cell activity, antibody-dependent cell-mediated cytotoxicity (ADCC), and on burst respiratory response of stimulated granulocytes as measured by chemiluminescence (CL) were studied in pigs. Six male weanling pigs were maintained for 25 d on a torula yeast-based diet containing no measurable amount of alpha-tocopherol and less than .02 mg of Se per kilogram of feed. Six others received the same basal diet supplemented with 33 IU of DL-alpha-tocopheryl acetate and ...
April 1991: Journal of Animal Science
T P Foley
There is evidence to suggest that elevated levels of iodide in the diet are associated with autoimmune thyroid disease (ATD) in susceptible individuals, and that autoimmune thyroiditis (Hashimoto's disease) is less common in susceptible individuals who live in regions with dietary iodine deficiency. There are epidemiologic studies in endemic goiter areas that report an increase in ATD, particularly thyroiditis, after the therapeutic administration of iodized salt, bread and oil. Lymphocytic infiltration of the thyroid is rarely found in patients from severe endemic goiter regions, yet there is a reversal of this observation after dietary iodine supplementation...
1992: Endokrynologia Polska
K L Fritsche, N A Cassity
The overall goal of the present study was to determine whether the incorporation of n-3 fatty acids into poultry rations would alter the immune response of broiler chickens. Female broiler chicks were fed a corn and soybean meal-based diet to which one of four dietary fats were added: lard (LA), corn oil (CO), flaxseed oil (SO), or menhaden fish oil (FO). The latter two fat sources are rich in n-3 polyunsaturated fatty acids (PUFA). Enriching the diet with n-3 PUFA did not alter the primary or secondary antibody response of broiler chickens to sheep red blood cells...
October 1992: Poultry Science
M Sabol, E Paulíková
The present study was designed to evaluate the effect of short ethanol intake on ADCC activity in blood and spleen mononuclear cells. Wistar rats were fed a standard diet and drank 0.1 M ethanol solution for three days. Glucose and water controls were used in this experiment. Increased ADCC activity was found in ethanol consuming rats in the blood and spleen as compared to both controls. Our findings support the assumption that ADCC may play an important role in liver disease of alcoholics.
1992: Physiological Research
G Fernandes, M Nair, K Onoe, T Tanaka, R Floyd, R A Good
Several immunologic features were analyzed in mice on a zinc-deficient diet [Zn(-)], in mice pair-fed a diet containing zinc [Zn(+)], in mice fed a Zn(+) diet ad lib, and in mice fed laboratory chow ad lib. When placed on a Zn(-) diet, 6- to 8-week-old A/Jax, C57BL/Ks, and CBA/H mice showed loss of body weight, low lymphoid tissue weight, and profound involution of the thymus within 4-8 weeks after initiation of the regimen. Approximately 50% of the mice on the Zn(-) diet developed severe acrodermatitis enteropathica (lesions on tail and paws) and diarrhea...
January 1979: Proceedings of the National Academy of Sciences of the United States of America
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