Read by QxMD icon Read


Nicole M Cordina, Nima Sayyadi, Lindsay M Parker, Arun Everest-Dass, Louise J Brown, Nicolle H Packer
Bio-imaging is a key technique in tracking and monitoring important biological processes and fundamental biomolecular interactions, however the interference of background autofluorescence with targeted fluorophores is problematic for many bio-imaging applications. This study reports on two novel methods for reducing interference with cellular autofluorescence for bio-imaging. The first method uses fluorescent nanodiamonds (FNDs), containing nitrogen vacancy centers. FNDs emit at near-infrared wavelengths typically higher than most cellular autofluorescence; and when appropriately functionalized, can be used for background-free imaging of targeted biomolecules...
March 14, 2018: Scientific Reports
L Basso, F Gorrini, M Cazzanelli, N Bazzanella, A Bifone, A Miotello
Nanodiamonds (NDs) containing negatively charged Nitrogen-Vacancy (NV) centers are promising materials for applications in photonics, quantum computing, and sensing of environmental parameters like temperature, strain and magnetic fields. However, the production of fluorescent NDs remains a technological challenge, requiring a complex multi-step process involving controlled introduction of substitutional nitrogen into the diamond lattice, annealing and fragmentation from macrocrystals to nanocrystals. Here, we report on a single-step, all-optical process for the production of nanometric-sized fluorescent diamonds based on laser ablation of a carbon substrate at low temperature (100 °C) under a nitrogen atmosphere...
March 14, 2018: Nanoscale
Huanan Li, Deping Zeng, Zhenyu Wang, Liaoqiong Fang, Faqi Li, Zhibiao Wang
AIM: To build up a combined therapy strategy to address limitations of the enhanced permeability and retention (EPR) effect and improve the efficiency of tumor therapy. MATERIALS & METHODS: A pH-sensitive nanocomplex for co-delivery of doxorubicin (DOX) and all-trans retinoic acid (ATRA) was developed based on nanodiamonds (DOX/ATRA-NDs) to enhance intracellular retention of drugs. Meanwhile, ultrasound was employed to enhance tumor vascular penetration of DOX-ATRA-NDs...
March 14, 2018: Nanomedicine
Ren-Mian Chin, Shinn-Jen Chang, Chia-Chen Li, Cha-Wen Chang, Ruo-Han Yu
HYPOTHESIS: Finding an efficient dispersant for obtaining a good dispersion of 5-nm detonation nanodiamond (DND) is always a challenge. Two newly designed diblock copolymers, both poly(ammonium methacrylate)-block-poly(2-phenoxyethyl acrylate) (PMA-b-PBEA) but with different molar ratios of PMA to PBEA, were proposed to be efficient dispersants in stabilizing the concentrated aqueous suspensions of DND. EXPERIMENTS: The dispersion efficiency of dispersants for DND in aqueous suspensions was studied by the measurements of particle size, sedimentation property, and rheological behavior...
March 7, 2018: Journal of Colloid and Interface Science
Yun Zeng, Wenyan Liu, Zheyu Wang, Srikanth Singamaneni, Risheng Wang
Surface functionalization of nanodiamonds (NDs), which is of great interest in advanced material and therapeutic applications, requires the immobilization of functional species, such as nucleic acids, bioprobes, drugs, and metal nanoparticles onto NDs' surfaces to form stable nanoconjugates. However, it is still challenging to modify the surface of NDs due to the complexity of their surface chemistry and the low density of each functional group on the surfaces of NDs. In this work, we demonstrate a general applicable surface functionalization approach for the preparation of ND-based core-shell nanoconjugates using dopamine polymerization...
March 12, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
Tyler Bowman, Alec Walter, Olga Shenderova, Nicholas Nunn, Gary McGuire, Magda El-Shenawee
THz imaging is effective in distinguishing between cancerous, healthy, and fatty tissues in breast tumors, but a challenge remains in the contrast between cancerous and fibroglandular (healthy) tissues. This work investigates carbon-based nanoparticles as potential contrast agents for terahertz imaging of breast cancer. Microdiamonds, nanodiamonds, and nanometer-scale onion-like carbon are characterized with terahertz transmission spectroscopy in low-absorption backgrounds of polydimethylsiloxane or polyethylene...
October 2017: Biomedical Physics & Engineering Express
Kai-Chih Chang, Chin-Yi Chung, Chen-Hsing Yeh, Kuo-Hsiu Hsu, Ya-Ching Chin, Sin-Siang Huang, Bo-Rong Liu, Hsi-An Chen, Anren Hu, Po-Chi Soo, Wen-Ping Peng
The appearance and spread of carbapenem-resistant Acinetobacter baumannii (CRAB) pose a challenge for optimization of antibiotic therapies and outbreak preventions. The carbapenemase production can be detected through culture-based methods (e.g. Modified Hodge Test-MHT) and DNA based methods (e.g. Polymerase Chain Reaction-PCR). The culture-based methods are time-consuming, whereas those of PCR assays need only a few hours but due to its specificity, can only detect known genetic targets encoding carbapenem-resistance genes...
February 27, 2018: Journal of Microbiological Methods
Jaroslav Jira, Bohuslav Rezek, Vitezslav Kriha, Anna Artemenko, Iva Matolínová, Viera Skakalova, Pavla Stenclova, Alexander Kromka
Nanodiamonds (NDs) and graphene oxide (GO) are modern carbon-based nanomaterials with promising features for the inhibition of microorganism growth ability. Here we compare the effects of nanodiamond and graphene oxide in both annealed (oxidized) and reduced (hydrogenated) forms in two types of cultivation media-Luria-Bertani (LB) and Mueller-Hinton (MH) broths. The comparison shows that the number of colony forming unit (CFU) of Escherichia coli is significantly lowered (45%) by all the nanomaterials in LB medium for at least 24 h against control...
March 1, 2018: Nanomaterials
Xiaoguang Duan, Hongqi Sun, Shaobin Wang
Catalytic processes have remarkably boosted the rapid industrializations in chemical production, energy conversion, and environmental remediation. As one of the emerging applications of carbocatalysis, metal-free nanocarbons have demonstrated promise as catalysts for green remediation technologies to overcome the poor stability and undesirable metal leaching in metal-based advanced oxidation processes (AOPs). Since our reports of heterogeneous activation of persulfates with low-dimensional nanocarbons, the novel oxidative system has raised tremendous interest for degradation of organic contaminants in wastewater without secondary contamination...
March 1, 2018: Accounts of Chemical Research
Ming Liu, Rong Xiang, Yaerim Lee, Keigo Otsuka, Ya-Lun Ho, Taiki Inoue, Shohei Chiashi, Jean-Jacques Delaunay, Shigeo Maruyama
We present a systematic study on the fabrication, characterization and high temperature surface enhanced Raman spectroscopy (SERS) performance of SiO2 coated silver nanoparticles (Ag@SiO2 ) on a flat substrate, aiming to obtain a thermally robust SERS substrate for monitoring high temperature reactions. We confirm that a 10-15 nm SiO2 coating provides a structure stability up to 900 °C without significantly sacrificing the enhancement factor, while the uncoated particle cannot retain the SERS effect above 500 °C...
March 1, 2018: Nanoscale
Sumin Choi, Victor Leong, Valery A Davydov, Viatcheslav N Agafonov, Marcus W O Cheong, Dmitry A Kalashnikov, Leonid A Krivitsky
Nanodidamonds containing colour centres open up many applications in quantum information processing, metrology, and quantum sensing. However, controlling the synthesis of nanodiamonds containing silicon vacancy (SiV) centres is still not well understood. Here we study nanodiamonds produced by a high-pressure high-temperature method without catalyst metals, focusing on two samples with clear SiV signatures. Different growth temperatures and relative content of silicon in the initial compound between the samples altered their nanodiamond size distributions and abundance of SiV centres...
February 28, 2018: Scientific Reports
Matthew D Ward, Haw-Tyng Huang, Li Zhu, Arani Biswas, Dmitry Popov, John V Badding, Timothy A Strobel
The 1 : 1 acetylene-benzene cocrystal, C2 H2 ·C6 H6 , was synthesized under pressure in a diamond anvil cell (DAC) and its evolution under pressure was studied with single-crystal X-ray diffraction and Raman spectroscopy. C2 H2 ·C6 H6 is stable up to 30 GPa, nearly 10× the observed polymerization pressure for molecular acetylene to polyacetylene. Upon mild heating at 30 GPa, the cocrystal was observed to undergo an irreversible transition to a mixture of amorphous hydrocarbon and a crystalline phase with similar diffraction to i-carbon, a nanodiamond polymorph currently lacking a definitive structure...
February 27, 2018: Physical Chemistry Chemical Physics: PCCP
Jingyi Zhao, Yuqing Cheng, Hongming Shen, Yuen Yung Hui, Te Wen, Huan-Cheng Chang, Qihuang Gong, Guowei Lu
In the surface-enhanced fluorescence (SEF) process, it is well known that the plasmonic nanostructure can enhance the light emission of fluorescent emitters. With the help of atomic force microscopy, a hybrid system consisting of a fluorescent nanodiamond and a gold nanoparticle was assembled step-by-step for in situ optical measurements. We demonstrate that fluorescent emitters can also enhance the light emission from gold nanoparticles which is judged through the intrinsic anti-Stokes emission owing to the nanostructures...
February 26, 2018: Scientific Reports
Jimmy T Trinh, Masfer H Alkahtani, Isaac Rampersaud, Arfaan Rampersaud, Marlan Scully, Ryland F Young, Philip Hemmer, Lanying Zeng
Rapid identification of specific bacterial strains within clinical, environmental, and food samples can facilitate the prevention and treatment of disease. Fluorescent nanodiamonds (FNDs) are being developed as biomarkers in biology and medicine, due to their excellent imaging properties, ability to accept surface modifications, and lack of toxicity. Bacteriophages, the viruses of bacteria, can have exquisite specificity for certain hosts. We propose to exploit the properties of FNDs and phages to develop phages conjugated with FNDs as long-lived fluorescent diagnostic reagents...
February 20, 2018: Biotechnology and Bioengineering
Abdulkareem Afandi, Ashley Howkins, Ian W Boyd, Richard B Jackman
The inclusion of boron within nanodiamonds to create semiconducting properties would create a new class of applications in the field of nanodiamond electronics. Theoretical studies have differed in their conclusions as to whether nm-scale NDs would support a stable substitutional boron state, or whether such a state would be unstable, with boron instead aggregating or attaching to edge structures. In the present study detonation-derived NDs with purposefully added boron during the detonation process have been studied with a wide range of experimental techniques...
February 19, 2018: Scientific Reports
Nikita Ronzhin, Alexey Puzyr, Vladimir Bondar
This paper demonstrates the effectiveness of using detonation nanodiamonds (DNDs) for detecting phenol in aqueous medium. The study has shown that the catalytic effect of DNDs in the oxidative azo coupling reaction (phenol-4-aminoantipyrine-hydrogen peroxide) is produced by trace amounts of iron and copper ions adsorbed on the surface of nanoparticles. The effectiveness of DNDs as a catalyst is determined by the amounts of these adsorbates and can be enhanced by a factor of two by additional adsorption of these ions onto the nanoparticles...
August 1, 2018: Journal of Nanoscience and Nanotechnology
Julie Bang, Caleb Ting, Peter Wang, Ted Kim, Kenneth Wang, Theodore Kee, Darron Miya, Dean Ho, Dong-Keun Lee
Current challenges in the field of regenerative medicine include the need to deliver sustained concentrations of growth factors and genes that are required to induce the repair of deficient tissues. Enhancement of drug delivery and uptake may result in improved growth factor efficacy. Nanodiamonds (NDs) were explored as potential growth factor delivery agents due to the many favorable properties that they possess. For example, ND's biocompatibility has been extensively validated pre-clinically. In addition, they can be scalably produced through impact events such as detonation...
February 19, 2018: Journal of Oral Implantology
Bingchao Cheng, Hao Pan, Dandan Liu, Dongyang Li, Jinyu Li, Shihui Yu, Guoxin Tan, Weisan Pan
The purpose of this work was to develop a D-α-tocopherol polyethylene glycol 1000 succinate (TPGS) decorated nanodiamond (ND) system loading water-insoluble curcumin (ND/CUR/TPGS) to improve the colloidal dispersity and oral bioavailability of the preparation. CUR was physically loaded into ND clusters, then TPGS was coated to the ND/CUR complex forming amorphous nanostructure on the interparticle nanocage of the ND substrate. The formulation of the nanocomplexes was optimized using response surface methodology, and the optimal ND/CUR/TPGS showed small particle size (196...
February 13, 2018: International Journal of Pharmaceutics
Mohamed Ibrahim, Ying Xue, Melanie Ostermann, Alexander Sauter, Doris Steinmueller-Nethl, Sarah Schweeberg, Anke Krueger, Mihaela R Cimpan, Kamal Mustafa
Scaffolds functionalized with nanodiamond particles (nDP) hold great promise with regard to bone tissue formation in animal models. Degradation of the scaffolds over time may leave nDP within the tissues, raising concerns about possible long-term unwanted effects. Human SaOS-2 osteoblast-like cells and U937 monoblastoid cells were exposed to 5 different concentrations (0.002-2 mg/L) of nDP (size range: 2.36 - 4.42 nm) for 24 h. Cell viability was assessed by impedance-based methods. The differential expression of stress and toxicity-related genes was evaluated by PCR super-array, while the expression of selected inflammatory and cell death markers was determined by qPCR...
February 16, 2018: Journal of Biomedical Materials Research. Part A
Hua Zhang, Li Zhang, Zhaodong Li, Qionghua Wu, Jianli Gao
In this study, three commercially available nanodiamonds (NDs) of similar size (about 5 nm in diameter) but with different surface chemistry (-COOH, -NH2 and -poly(ethylene glycol)) were used to study the toxicity and immune activation of Raw264.7 cells. Only ND-PEG is well dispersed in water and cell culture medium (about 10 nm in diameter), while ND-COOH and ND-NH2 only showed some aggregation, about 50 nm in water and about 100 nm in cell culture medium. The three NDs showed different zeta potentials in water but the difference disappeared in cell culture medium due to the surface adsorption of the proteins...
February 1, 2018: Journal of Nanoscience and Nanotechnology
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"