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Settimio Pacelli, Francisca Acosta, Aparna R Chakravarti, Saheli G Samanta, Jonathan Whitlow, Saman Modaresi, Rafeeq P H Ahmed, Johnson Rajasingh, Arghya Paul
Nanodiamonds (NDs) represent an emerging class of carbon nanomaterials that possess favorable physical and chemical properties to be used as multifunctional carriers for a variety of bioactive molecules. Here we report the synthesis and characterization of a new injectable ND-based nanocomposite hydrogel which facilitates a controlled release of therapeutic molecules for regenerative applications. In particular, we have formulated a thermosensitive hydrogel using gelatin, chitosan and NDs that provides a sustained release of exogenous human vascular endothelial growth factor (VEGF) for wound healing applications...
May 19, 2017: Acta Biomaterialia
Gufei Zhang, Tomas Samuely, Zheng Xu, Johanna K Jochum, Alexander Volodin, Shengqiang Zhou, Paul W May, Oleksandr Onufriienko, Jozef Kačmarčík, Julian A Steele, Jun Li, Johan Vanacken, Jiri Vacík, Pavol Szabó, Haifeng Yuan, Maarten B J Roeffaers, Dorin Cerbu, Peter Samuely, Johan Hofkens, Victor V Moshchalkov
Superconductivity and ferromagnetism are two mutually antagonistic states in condensed matter. Research on the interplay between these two competing orderings sheds light not only on the cause of various quantum phenomena in strongly correlated systems but also on the general mechanism of superconductivity. Here we report on the observation of the electronic entanglement between superconducting and ferromagnetic states in hydrogenated boron-doped nanodiamond films, which have a superconducting transition temperature Tc ~ 3 K and a Curie temperature TCurie > 400 K...
May 16, 2017: ACS Nano
Xingjie Hu, Xiaojiao Li, Min Yin, Ping Li, Ping Huang, Lihua Wang, Yiguo Jiang, Hui Wang, Nan Chen, Chunhai Fan, Haiyun Song
Introduction of exogenous biomacromolecules into living systems is of great interest in genome editing, cancer immunotherapy, and stem cell reprogramming. Whereas current strategies generally depend on nucleic acids transfection, direct delivery of functional proteins that provides enhanced specificity, increased safety, and fast and temporal regulation is highly desirable. Nevertheless, intracellular delivery of intact and bioactive proteins, especially in vivo, remains poorly explored. In this study, we developed a nanodiamonds (NDs)-based protein delivery system in cultured cells and in Drosophila that showed high adsorption, high efficiency, and effective cytosolic release of fully functional proteins...
May 23, 2017: ACS Applied Materials & Interfaces
Sebastian K H Andersen, Shailesh Kumar, Sergey I Bozhevolnyi
We demonstrate an exceptionally bright photon source based on a single nitrogen-vacancy center (NV center) in a nanodiamond (ND) placed in the nanoscale gap between two monocrystalline silver cubes in a dimer configuration. The system is operated near saturation at a stable photon rate of 850 kcps, while we further achieve strongly polarized emission and high single photon purity, evident by the measured autocorrelation with a g((2))(0) value of 0.08. These photon source features are key parameters for quantum technological applications, such as secure communication based on quantum key distribution...
May 8, 2017: Nano Letters
Vanish Kumar, Rashmi Mahajan, Inderpreet Kaur, Ki-Hyun Kim
In an effort to develop a simple and mediator-free sensing media for urea, a polyaniline (PANI) and graphitized nanodiamond (GND) nanocomposite was prepared at room temperature via an in situ interfacial polymerization approach. The interaction of ions produced during the hydrolysis of urea with nanomaterial was utilized for the amperometric sensing of urea. The performance of this composite (GND/PANI) was evaluated for the detection of urea referenced to PANI. Accordingly, both platforms exhibited good linearity across a varying concentration of 0...
May 10, 2017: ACS Applied Materials & Interfaces
Yangming Lin, Zhenbao Feng, Linhui Yu, Qinging Gu, Shuchang Wu, Dang Sheng Su
Ultra-dispersed nanodiamond and its derivatives (UNDDs), including bucky nanodiamond and onion-like carbon, offer superior catalytic behavior relative to other nanocarbons. However, a systematic study of their unique properties has been rarely achieved. Their surface chemistry and electronic properties are therefore studied to reveal the essential differences of UNDDs compared to other nanocarbons for catalysis.
April 27, 2017: Chemical Communications: Chem Comm
David E J Waddington, Mathieu Sarracanie, Huiliang Zhang, Najat Salameh, David R Glenn, Ewa Rej, Torsten Gaebel, Thomas Boele, Ronald L Walsworth, David J Reilly, Matthew S Rosen
Nanodiamonds are of interest as nontoxic substrates for targeted drug delivery and as highly biostable fluorescent markers for cellular tracking. Beyond optical techniques, however, options for noninvasive imaging of nanodiamonds in vivo are severely limited. Here, we demonstrate that the Overhauser effect, a proton-electron polarization transfer technique, can enable high-contrast magnetic resonance imaging (MRI) of nanodiamonds in water at room temperature and ultra-low magnetic field. The technique transfers spin polarization from paramagnetic impurities at nanodiamond surfaces to (1)H spins in the surrounding water solution, creating MRI contrast on-demand...
April 26, 2017: Nature Communications
Zahra Delavar, Akbar Shojaei
Polymer composite films based on chitosan (CS) and nanodimaond (ND) were prepared using solution casting method. ND with variable contents of carboxylic functional group was prepared using thermal oxidation at temperature of 420°C under air atmosphere at various durations of 1.5 and 4.5h. The interfacial interaction between NDs and CS and morphological evolution of CS in presence of NDs were investigated by Fourier transform infrared (FTIR), differential scanning calorimeter (DSC) and X-ray diffraction (XRD) analyses...
July 1, 2017: Carbohydrate Polymers
Zhenpeng Ge, Yi Wang
Molecular dynamics simulations of nanoparticles (NPs) are increasingly used to study their interactions with various biological macromolecules. Such simulations generally require detailed knowledge of the surface composition of the NP under investigation. Even for some well-characterized nanoparticles, however, this knowledge is not always available. An example is nanodiamond, a nanoscale diamond particle with surface dominated by oxygen-containing functional groups. In this work, we explore using the harmonic restraint method developed by Venable et al...
April 20, 2017: Journal of Physical Chemistry. B
Huiliang Zhang, David R Glenn, Richard Schalek, Jeff W Lichtman, Ronald L Walsworth
Correlated electron microscopy and cathodoluminescence (CL) imaging using functionalized nanoparticles is a promising nanoscale probe of biological structure and function. Nanodiamonds (NDs) that contain CL-emitting color centers are particularly well suited for such applications. The intensity of CL emission from NDs is determined by a combination of factors, including particle size, density of color centers, efficiency of energy deposition by electrons passing through the particle, and conversion efficiency from deposited energy to CL emission...
April 18, 2017: Small
Xiaoguang Duan, Hongqi Sun, Shaobin Wang
No abstract text is available yet for this article.
April 14, 2017: Environmental Science & Technology
Hongshin Lee, Changha Lee, Jae-Hong Kim
No abstract text is available yet for this article.
April 14, 2017: Environmental Science & Technology
Bokai Zhang, Xi Feng, Hang Yin, Zhenpeng Ge, Yanhuan Wang, Zhiqin Chu, Helena Raabova, Jan Vavra, Petr Cigler, Renbao Liu, Yi Wang, Quan Li
Nanoparticle-cell interactions begin with the cellular uptake of the nanoparticles, a process that eventually determines their cellular fate. In the present work, we show that the morphological features of nanodiamonds (NDs) affect both the anchoring and internalization stages of their endocytosis. While a prickly ND (with sharp edges/corners) has no trouble of anchoring onto the plasma membrane, it suffers from difficult internalization afterwards. In comparison, the internalization of a round ND (obtained by selective etching of the prickly ND) is not limited by its lower anchoring amount and presents a much higher endocytosis amount...
April 13, 2017: Scientific Reports
Shine Augustine, Jay Singh, Manish Srivastava, Monica Sharma, Asmita Das, Bansi D Malhotra
One of the major challenges in our contemporary society is to facilitate healthy life for all human beings. In this context, cancer has become one of the most deadly diseases around the world, and despite many advances in theranostics techniques the treatment of cancer still remains an important problem. With recent advances made in the field of nano-biotechnology, carbon-based nanostructured materials have drawn special attention because of their unique physicochemical properties, giving rise to great potential for the diagnosis and therapy of cancer...
May 2, 2017: Biomaterials Science
Taira Tasaki, Yifei Guo, Qi Meng, Muhammad Abdullah Al Mamun, Yusuke Kasahara, Shuichi Akasaka, Atsuhiro Fujimori
The formation behavior of organized organo-modified nanodiamond films and polymer nanocomposites has been investigated using nanodiamonds of several different particle sizes and outermost-surface compositions. The nanodiamond particle sizes used in this study were 3 and 5 nm, and the outermost surface contained -OH and/or -COOH groups. The nanodiamond was organo-modified to prepare -OH2(+) cations and -COO(-) anions on the outermost surface by carboxylic anion of fatty acid and long-chain phosphonium cation, respectively...
April 17, 2017: ACS Applied Materials & Interfaces
S R Hemelaar, P de Boer, M Chipaux, W Zuidema, T Hamoh, F Perona Martinez, A Nagl, J P Hoogenboom, B N G Giepmans, R Schirhagl
Nanodiamonds containing fluorescent nitrogen-vacancy centers are increasingly attracting interest for use as a probe in biological microscopy. This interest stems from (i) strong resistance to photobleaching allowing prolonged fluorescence observation times; (ii) the possibility to excite fluorescence using a focused electron beam (cathodoluminescence; CL) for high-resolution localization; and (iii) the potential use for nanoscale sensing. For all these schemes, the development of versatile molecular labeling using relatively small diamonds is essential...
April 7, 2017: Scientific Reports
Kostiantyn Turcheniuk, Vadym Mochalin
The interest to applications of nanodiamond in biology and medicine is on the rise over the recent years. This is due to the unique combination of properties that nanodiamond provides. Small size (~ 5 nm), low cost, scalable production, negligible toxicity, chemical inertness of diamond core and rich chemistry of nanodiamond surface, as well as bright and robust fluorescence resistant to photobleaching are the distinct parameters that render nanodiamond superior to any other nanomaterial when it comes to biomedical applications...
April 3, 2017: Nanotechnology
Tao Wang, Stephan Handschuh-Wang, Panpan Qin, Yang Yang, Xuechang Zhou, Yongbing Tang
Colloidal stability of nanoparticles with particle sizes smaller than 100nm is a critical issue for various research areas, including material science, electronics and biomedicine. We propose a facile, fast and cost-efficient method to increase the colloidal stability by simply adding organic molecules as ligands, which adsorb to the nanoparticle surface subsequently. Citric acid, oxalic acid, glutamic acid and propylamine were found to stabilize the nanodiamond (ND) particles with a mean diameter of approx...
March 25, 2017: Journal of Colloid and Interface Science
Long-Jyun Su, Meng-Shiue Wu, Yuen Yung Hui, Be-Ming Chang, Lei Pan, Pei-Chen Hsu, Yit-Tsong Chen, Hong-Nerng Ho, Yen-Hua Huang, Thai-Yen Ling, Hsao-Hsun Hsu, Huan-Cheng Chang
Cell therapy is a promising strategy for the treatment of human diseases. While the first use of cells for therapeutic purposes can be traced to the 19th century, there has been a lack of general and reliable methods to study the biodistribution and associated pharmacokinetics of transplanted cells in various animal models for preclinical evaluation. Here, we present a new platform using albumin-conjugated fluorescent nanodiamonds (FNDs) as biocompatible and photostable labels for quantitative tracking of human placenta choriodecidual membrane-derived mesenchymal stem cells (pcMSCs) in miniature pigs by magnetic modulation...
March 30, 2017: Scientific Reports
Shiyan Fu, Shu Wang, Xiaodi Zhang, Anhui Qi, Zhirong Liu, Xin Yu, Chuanfang Chen, Linlin Li
Ferromagnetic nanoparticles (Fe3O4 NPs) have been proven to have the intrinsic peroxidase-like activity. This property has been used for analyte detection, tumor tissue visualization, and cancer therapy, etc. However, the effect of particle structure and morphology on its peroxidase-like activity has been rarely reported. In this work, we fabricated Fe3O4 nanoparticles with different structures (nanoclusters, nanoflowers, and nanodiamonds) by facilely tuning the pH values in the hydrothermal reaction. Their in vitro peroxidase-like activity was evaluated via chromogenic reaction of 3,3',5,5'-tetramethylbenzidine (TMB) by the reduction of H2O2 to H2O...
June 1, 2017: Colloids and Surfaces. B, Biointerfaces
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