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Margaret E Robinson, James D Ng, Huilong Zhang, Joseph T Buchman, Olga A Shenderova, Christy L Haynes, Zhenqiang Ma, Randall H Goldsmith, Robert J Hamers
While there is great interest in understanding the fate and transport of nanomaterials in the environment and in biological systems, the detection of nanomaterials in complex matrices by fluorescence methods is complicated by photodegradation, blinking, and by the presence of natural organic material and other fluorescent background signals that hamper detection of fluorescent nanomaterials of interest. Optically detected magnetic resonance (ODMR) of nitrogen-vacancy (NV) centers in diamond nanoparticles provides a pathway toward background-free fluorescence measurements, as the application of a resonant microwave field can selectively modulate the intensity from NV centers in the diamond in nanodiamonds of various diameters in complex materials systems using on-resonance and off-resonance microwave fields...
November 13, 2017: Analytical Chemistry
Na Song, Siqi Cui, Xingshuang Hou, Peng Ding, Liyi Shi
High thermal conductive nanofibrillated cellulose (NFC) hybrid films based on nanodiamond (ND) were fabricated by a facile vacuum filtration technique. In this issue, the thermal conductivity (TC) on the in-plane direction of the NFC/ND hybrid film had a significant enhancement of 775.2% at a comparatively low ND content (0.5 wt %). The NFC not only helps ND to disperse in the aqueous medium stably but also plays a positive role in the formation of the hierarchical structure. ND could form a thermal conductive pathway in the hierarchical structures under the intermolecular hydrogen bonds...
November 10, 2017: ACS Applied Materials & Interfaces
Sanju Gupta, Brendan Evans, Alex Henson, Sara B Carrizosa
Nanodiamond particles form agglomerates in the dry powder state and this poses limitation to the accessibility of their diamond-like core thus dramatically impacting their technological advancement. In this work, we report de-agglomeration of nanodiamond (ND) by using a facile technique namely, salt-assisted ultrasonic de-agglomeration (SAUD). Utilizing ultrasound energy and ionic salts (sodium chloride and sodium acetate), SAUD is expected to break apart thermally treated nanodiamond aggregates (~50-100 nm) and produce an aqueous slurry of de-aggregated stable colloidal nanodiamond dispersions by virtue of ionic interactions and electrostatic stabilization...
November 10, 2017: Materials
Gufei Zhang, Tomas Samuely, Hongchu Du, Zheng Xu, Liwang Liu, Oleksandr Onufriienko, Paul W May, Johan Vanacken, Pavol Szabó, Jozef Kačmarčík, Haifeng Yuan, Peter Samuely, Rafal E Dunin-Borkowski, Johan Hofkens, Victor V Moshchalkov
In the presence of disorder, superconductivity exhibits short-range characteristics linked to localized Cooper pairs which are responsible for anomalous phase transitions and the emergence of quantum states such as the bosonic insulating state. Complementary to well-studied homogeneously disordered superconductors, superconductor-normal hybrid arrays provide tunable realizations of the degree of granular disorder for studying anomalous quantum phase transitions. Here, we investigate the superconductor-bosonic dirty metal transition in disordered nanodiamond arrays as a function of the dispersion of intergrain spacing, which ranges from angstroms to micrometers...
November 13, 2017: ACS Nano
Tingting Zheng, Felipe P Perona Martinez, Ingeborg Maria Storm, Wolf Rombouts, Joris Sprakel, Romana Schirhagl, Renko de Vries
Fluorescent nanodiamonds are gaining increasing attention as fluorescent labels in biology in view of the fact that they are essentially non-toxic, do not bleach, and can be used as nanoscale sensors for various physical and chemical properties. To fully realize the nanosensing potential of nanodiamonds in biological applications, two problems need to be addressed: their limited colloidal stability, especially in presence of salts, and their limited ability to be taken up by cells. We show that the physical adsorption of a suitably designed recombinant polypeptide can address both the colloidal stability problem and the problem of the limited uptake of nanodiamonds by cells in a very straightforward way, while preserving both their spectroscopic properties and their excellent biocompatibility...
November 7, 2017: Analytical Chemistry
David A Simpson, Emma Morrisroe, Julia M McCoey, Alain H Lombard, Dulini C Mendis, François Treussart, Liam T Hall, Steven Petrou, Lloyd C L Hollenberg
Optical biomarkers have been used extensively for intracellular imaging with high spatial and temporal resolution. Extending the modality of these probes is a key driver in cell biology. In recent years, the nitrogen-vacancy (NV) center in nanodiamond has emerged as a promising candidate for bioimaging and biosensing with low cytotoxicity and stable photoluminescence. Here we study the electrophysiological effects of this quantum probe in primary cortical neurons. Multielectrode array recordings across five replicate studies showed no statistically significant difference in 25 network parameters when nanodiamonds are added at varying concentrations over various time periods, 12-36 h...
November 13, 2017: ACS Nano
Dong-Keun Lee, Theodore Kee, Zhangrui Liang, Desiree Hsiou, Darron Miya, Brian Wu, Eiji Osawa, Edward Kai-Hua Chow, Eric C Sung, Mo K Kang, Dean Ho
Detonation nanodiamonds (NDs) are promising drug delivery and imaging agents due to their uniquely faceted surfaces with diverse chemical groups, electrostatic properties, and biocompatibility. Based on the potential to harness ND properties to clinically address a broad range of disease indications, this work reports the in-human administration of NDs through the development of ND-embedded gutta percha (NDGP), a thermoplastic biomaterial that addresses reinfection and bone loss following root canal therapy (RCT)...
October 23, 2017: Proceedings of the National Academy of Sciences of the United States of America
V Pichot, O Muller, A Seve, A Yvon, L Merlat, D Spitzer
Detonation nanodiamonds exhibit strong nonlinear optical properties depending on their electronic properties. In the present paper, the nanodiamond functional groups are chemically modified to obtain nanodiamonds with primary amines on their surface. The optical properties of such nanodiamonds placed in water suspensions are studied and compared with the one of classical detonation nanodiamonds. Transmission, scattering and Z-scan experiments are performed for two different wavelengths (532 nm and 1064 nm)...
October 26, 2017: Scientific Reports
Tong-Fei Li, Ke Li, Chao Wang, Xin Liu, Yu Wen, Yong-Hong Xu, Quan Zhang, Qiu-Ya Zhao, Ming Shao, Yan-Ze Li, Min Han, Naoki Komatsu, Li Zhao, Xiao Chen
Glioblastoma (GBM) is the most frequent and malignant brain tumor with a high mortality rate. The presence of a large population of macrophages (Mφ) in the tumor microenvironment is a prominent feature of GBM and these so-called tumor-associated Mφ (TAM) closely interact with the GBM cells to promote the survival, progression and therapy resistance of the GBM. Various therapeutic strategies have been devised either targeting the GBM cells or the TAM but few have addressed the cross-talks between the two cell populations...
October 16, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
Linda-Lucila Landeros-Martinez, Daniel Glossman-Mitnik, Erasmo Orrantia-Borunda, Norma Flores-Holguín
The use of nanodiamonds as anticancer drug delivery vehicles has received much attention in recent years. In this theoretical paper, we propose using different esterification methods for nanodiamonds. The monomers proposed are 2-hydroxypropanal, polyethylene glycol, and polyglicolic acid. Specifically, the hydrogen bonds, infrared (IR) spectra, molecular polar surface area, and reactivity parameters are analyzed. The monomers proposed for use in esterification follow Lipinski's rule of five, meaning permeability is good, they have good permeation, and their bioactivity is high...
October 19, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Najmeh Sadat Hosseini Motlagh, Parviz Parvin, Mitra Refahizadeh, Ali Bavali
The effect of graphene oxide (GO) and nanodiamond (ND) is investigated on the spectral properties of doxorubicin (DOX) fluorescence emissions in the form of (DOX+GO) and (DOX+ND) biomaterials. It is shown that carbon nanostructure additives lead to sensible blueshifts, due to their optical properties and surface functionality. The quenching coefficient KND is obtained to be KND=0.043  (μg/ml)(-1) and KGO=0.342  (μg/ml)(-1) in DOX solutions. In general, Stern-Volmer attests that excited (DOX+GO) strongly quenches with respect to that of (DOX+ND) regarding its privileged bonding affinity...
September 10, 2017: Applied Optics
Colin K Curtis, Antonin Marek, Alex I Smirnov, Jacqueline Krim
This article reports a comparative study of the nanoscale and macroscale tribological attributes of alumina and stainless steel surfaces immersed in aqueous suspensions of positively (hydroxylated) or negatively (carboxylated) charged nanodiamonds (ND). Immersion in -ND suspensions resulted in a decrease in the macroscopic friction coefficients to values in the range 0.05-0.1 for both stainless steel and alumina, while +ND suspensions yielded an increase in friction for stainless steel contacts but little to no increase for alumina contacts...
2017: Beilstein Journal of Nanotechnology
Pardeep Kumar, M Bhattacharya
We analyze magnetometry using an optically levitated nanodiamond. We consider a configuration where a magnetic field gradient couples the mechanical oscillation of the diamond with its spin degree of freedom provided by a nitrogen vacancy center. First, we investigate the measurement of the position spectrum of the mechanical oscillator. We find that conditions of ultrahigh vacuum and feedback cooling allow a magnetic field gradient sensitivity of 1μTm(-1)/Hz. At high pressure and room temperature, this sensitivity degrades and can attain a value of the order of 100mTm(-1)/Hz...
August 7, 2017: Optics Express
Yongqian Zhang, Charles G Fry, Joel A Pedersen, Robert J Hamers
Nanoparticles are frequently modified with polymer layers to control their physical and chemical properties, but little is understood about the morphology and dynamics of these polymer layers. We report here an NMR-based investigation of a model polymer-modified nanoparticle, using multiple NMR techniques including (1)H NMR, diffusion-ordered spectroscopy (DOSY), total correlation spectroscopy (TOCSY), and T2 relaxometry to characterize the dynamics of the nanoparticle-polymer interface. Using 5 nm detonation nanodiamond covalently linked to poly(allylamine) hydrochloride as a model system, we demonstrate the use of NMR to distinguish between free and bound polymer and to characterize the degree to which the segments of the nanoparticle-wrapping polymer are mobile (loops and tails) versus immobile (trains)...
November 7, 2017: Analytical Chemistry
Stepan Stehlik, Marian Varga, Pavla Stenclova, Lukas Ondic, Martin Ledinsky, Jiri Pangrac, Ondrej Vanek, Jan Lipov, Alexander Kromka, Bohuslav Rezek
Color centers in diamonds have shown excellent potential for applications in quantum information processing, photonics, and biology. Here we report chemical vapor deposition (CVD) growth of nanocrystalline diamond (NCD) films as thin as 5-6 nm with photoluminescence (PL) from silicon-vacancy (SiV) centers at 739 nm. Instead of conventional 4-6 nm detonation nanodiamonds (DNDs), we prepared and employed hydrogenated 2 nm DNDs (zeta potential = +36 mV) to form extremely dense (∼1.3 × 10(13) cm(-2)), thin (2 ± 1 nm), and smooth (RMS roughness < 0...
November 8, 2017: ACS Applied Materials & Interfaces
Xin Wang, Mengjie Gu, Tan Boon Toh, Nurrul Lissa Binti Abdullah, Edward Kai-Hua Chow
Metastasis is often critical to cancer progression and linked to poor survival and drug resistance. Early detection of metastasis, as well as identification of metastatic tumor sites, can improve cancer patient survival. Thus, developing technology to improve the detection of cancer metastasis biomarkers can improve both diagnosis and treatment. In this study, we investigated the use of nanodiamonds to develop a stimuli-responsive metastasis detection complex that utilizes matrix metalloproteinase 9 (MMP9) as a metastasis biomarker, as MMP9 increased expression has been shown to be indicative of metastasis...
October 1, 2017: SLAS Technology
Mikhail Popov, Valentin Churkin, Alexey Kirichenko, Viktor Denisov, Danila Ovsyannikov, Boris Kulnitskiy, Igor Perezhogin, Viktor Aksenenkov, Vladimir Blank
Nanodiamond in a 2-5-nm size interval (which is typical for an appearance of quantum confinement effect) show Raman spectra composed of 3 bands at 1325, 1600, and 1500 cm(-1) (at the 458-nm laser excitation) which shifts to 1630 cm(-1) at the 257-nm laser excitation. Contrary to sp(2)-bonded carbon, relative intensities of the bands do not depend on the 458- and 257-nm excitation wavelengths, and a halfwidth and the intensity of the 1600 cm(-1) band does not change visibly under pressure at least up to 50 GPa...
October 10, 2017: Nanoscale Research Letters
T M Chen, X M Tian, L Huang, J Xiao, G W Yang
Nanodiamonds (NDs) have recently become a focus of interest from the viewpoints of both science and technology. Their intriguing properties make them suitable as biologically active substrates, in biosensor applications as well as diagnostic and therapeutic biomedical imaging probes. Here, we demonstrate that NDs, as oxidation and reduction catalysts, possess intrinsic enzyme mimetic properties of oxidase, peroxidase and catalase, and these behaviors can be switched by modulating the pH value. NDs not only catalyze the reduction of oxygen (O2) and hydrogen peroxide (H2O2) at acidic pH, but also catalyze the dismutation decomposition of H2O2 to produce O2 at alkaline pH...
October 19, 2017: Nanoscale
Ngoc Bich Pham, Thuong Thi Ho, Giang Thu Nguyen, Thuy Thi Le, Ngoc Thu Le, Huan-Cheng Chang, Minh Dinh Pham, Udo Conrad, Ha Hoang Chu
BACKGROUND: The continuing spread of the newly emerged H7N9 virus among poultry in China, as well as the possibility of human-to-human transmission, has attracted numerous efforts to develop an effective vaccine against H7N9. The use of nanoparticles in vaccinology is inspired by the fact that most pathogens have a dimension within the nano-size range and therefore can be processed efficiently by the immune system, which leads to a potent immune response. Herein, we report a facile approach to increase antigen size to achieve not only fast but also effective responses against the recombinant HA/H7N9 protein via a simple conjugation of the protein onto the surface of nanodiamond particles...
October 5, 2017: Journal of Nanobiotechnology
Qingxia Zhao, Qiming Mao, Yaoyu Zhou, Jianhong Wei, Xiaocheng Liu, Junying Yang, Lin Luo, Jiachao Zhang, Hong Chen, Hongbo Chen, Lin Tang
In recent years, advanced oxidation processes (AOPs), especially sulfate radical based AOPs have been widely used in various fields of wastewater treatment due to their capability and adaptability in decontamination. Recently, metal-free carbon materials catalysts in sulfate radical production has been more and more concerned because these materials have been demonstrated to be promising alternatives to conventional metal-based catalysts, but the review of metal-free catalysts is rare. The present review outlines the current state of knowledge on the generation of sulfate radical using metal-free catalysts including carbon nanotubes, graphene, mesoporous carbon, activated carbon, activated carbon fiber, nanodiamond...
September 13, 2017: Chemosphere
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