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Yan-Kai Tzeng, Jingyuan Linda Zhang, Haiyu Lu, Hitoshi Ishiwata, Jeremy Dahl, Robert M K Carlson, Hao Yan, Peter R Schreiner, Jelena Vuckovic, Zhi-Xun Shen, Nicholas A Melosh, Steven Chu
Color center-containing nanodiamonds have many applications in quantum technologies and biology. Diamondoids, molecular-sized diamonds have been used as seeds in Chemical Vapor Deposition (CVD) growth. However, optimizing growth conditions to produce high crystal quality nanodiamonds with color centers requires varying growth conditions that often leads to ad-hoc and time-consuming, one-at-a-time testing of reaction conditions. In order to rapidly explore parameter space, we developed a microwave plasma CVD technique using a vertical, rather than horizontally oriented stage-substrate geometry...
February 9, 2017: Nano Letters
ChienHsu Chen, I C Cho, Hui-Shan Jian, H Niu
Here we present a simple physical method to prepare magnetic nanodiamonds (NDs) using high dose Fe ion-implantation. The Fe atoms are embedded into NDs through Fe ion-implantation and the crystal structure of NDs are recovered by thermal annealing. The results of TEM and Raman examinations indicated the crystal structure of the Fe implanted NDs is recovered completely. The SQUID-VSM measurement shows the Fe-NDs possess room temperature ferromagnetism. That means the Fe atoms are distributed inside the NDs without affecting NDs crystal structure, so the NDs can preserve the original physical and chemical properties of the NDs...
February 9, 2017: Scientific Reports
H Moche, V Paget, D Chevalier, E Lorge, N Claude, H A Girard, J C Arnault, S Chevillard, F Nesslany
Nanodiamonds (NDs) are promising nanomaterials for biomedical applications. However, a few studies highlighted an in vitro genotoxic activity for detonation NDs, which was not evidenced in one of our previous work quantifying γ-H2Ax after 20 and 100 nm high-pressure high-temperature ND exposures of several cell lines. To confirm these results, in the present work, we investigated the genotoxicity of the same 20 and 100 nm NDs and added intermediate-sized NDs of 50 nm. Conventional in vitro genotoxicity tests were used, i...
February 6, 2017: Journal of Applied Toxicology: JAT
Martin Falk
No abstract text is available yet for this article.
January 2017: Annals of Translational Medicine
Pei-Chang Tsai, Chandra P Epperla, Jo-Shan Huang, Oliver Y Chen, Chih-Che Wu, Huan-Cheng Chang
Much of the current understanding of thermal effects in biological systems is based on macroscopic measurements. There is little knowledge about the local thermostability or heat tolerance of subcellular components at the nanoscale. Herein, we show that gold nanorod-fluorescent nanodiamond (GNR-FND) hybrids are useful as a combined nanoheater/nanothermometer in living cells. With the use of a 594 nm laser for both heating and probing, we measure the temperature changes by recording the spectral shifts of the zero-phonon lines of negatively charged nitrogen-vacancy centers in FNDs...
January 31, 2017: Angewandte Chemie
Mohammed A Yassin, Kamal Mustafa, Zhe Xing, Yang Sun, Kristine Eldevik Fasmer, Thilo Waag, Anke Krueger, Doris Steinmüller-Nethl, Anna Finne-Wistrand, Knut N Leknes
Functionalizing polymer scaffolds with nanodiamond particles (nDPs) has pronounced effect on the surface properties, such as improved wettability, an increased active area and binding sites for cellular attachment and adhesion, and increased ability to immobilize biomolecules by physical adsorption. This study aims to evaluate the effect of poly(l-lactide-co-ε-caprolactone) (poly(LLA-co-CL)) scaffolds, functionalized with nDPs, on bone regeneration in a rat calvarial critical size defect. Poly(LLA-co-CL) scaffolds functionalized with nDPs are also compared with pristine scaffolds with reference to albumin adsorption and seeding efficiency of bone marrow stromal cells (BMSCs)...
January 24, 2017: Macromolecular Bioscience
S Y Ong, M Chipaux, A Nagl, R Schirhagl
Nanodiamonds with dimensions down to a few tens of nanometers containing nitrogen-vacancy (NV) color centers have revealed their potential as powerful and versatile quantum sensors with a unique combination of spatial resolution and sensitivity. The NV centers allow transducing physical properties, such as strain, temperature, and electric or magnetic field, to an optical transition that can be detected in the single photon range. For example, this makes it possible to sense a single electron spin or a few nuclear spins by detecting their magnetic resonance...
January 23, 2017: Physical Chemistry Chemical Physics: PCCP
Li Zhou, Huayang Zhang, Xiaochen Guo, Hongqi Sun, Shaomin Liu, Moses O Tade, Shaobin Wang
Graphitic carbon nitride (g-C3N4) has been considered as a metal-free, cost-effective, eco-friendly and efficient catalyst for various photoelectrochemical applications. However, compared to conventional metal-based photocatalysts, its photocatalytic activity is still low because of the low mobility of carriers restricted by the polymer nature. Herein, a series of hybrids of g-C3N4 (GCN) and nanodiamonds (NDs) were synthesized using a solvothermal method. The photoelectrochemical performance and photocatalytic efficiency of the GCN/NDs were investigated by means of the generation of photocurrent and photodegradation of methylene blue (MB) solutions under UV-visible light irradiations...
January 12, 2017: Journal of Colloid and Interface Science
K-J Huang, C-Y Lee, Y-C Lin, C-Y Lin, E Perevedentseva, S-F Hung, C-L Cheng
The applications of nanodiamond as drug delivery and bio-imaging can require the relinquishing ND-drug conjugate via blood flow, where interaction with immune cells may occur. In this work, we investigated the ND penetration in macrophage and the immune response using the tissue-resident murine macrophages (RAW 264.7). Confocal fluorescence imaging, immunofluorescence analysis of nuclear translocation of interferon regulatory factor IRF-3 and transcriptional factor NF-κΒ, analysis of pro-inflammatory cytokines production IL-1β, IL-6 IL-10 with a reverse transcription-polymerase chain reaction technique were applied...
January 9, 2017: Journal of Biophotonics
Magdalena Kurzyp, Hugues A Girard, Yannis Cheref, Emilie Brun, Cecile Sicard-Roselli, Samuel Saada, Jean-Charles Arnault
For the first time, overproduction of hydroxyl radicals (HO˙) induced by plasma hydrogenated detonation nanodiamonds (H-NDs) under X-ray irradiation is reported. Using coumarin (COU) as a fluorescent probe, we reveal a significant increase of 40% of the HO˙ production in the presence of H-NDs (6-100 μg ml(-1)) compared with water alone. This effect is related to the negative electron affinity of the hydrogenated nanodiamonds and illustrates the ability of H-NDs to produce reactive oxygen species probably via electron emission in water under X-ray irradiation...
January 19, 2017: Chemical Communications: Chem Comm
Xiongwei Deng, Zhaoxia Yin, Jianqing Lu, Yang Xia, Leihou Shao, Qin Hu, Zhixiang Zhou, Fang Zhang, Shaomei Zhou, Yan Wu, Wang Sheng, Yi Zeng
Theranostic nanoparticles with combined imaging and therapy functions show great promise in cancer precision medicine. In this study, we constructed near-infrared (NIR) "OFF-ON" fluorescent nanohybrids (F-PNDs) for synchronous tumor imaging and microRNA (miRNA) modulation therapy against esophageal cancer. Nanodiamond clusters (NDs) were first functionalized for protamine sulfate immobilization (PNDs) on their surfaces via a noncovalent self-assembling approach and simultaneous encapsulation of NIR emitting fluorescence dye cyanine 5 (Cy-5) (F-PNDs)...
February 1, 2017: ACS Applied Materials & Interfaces
Ewa Rej, Torsten Gaebel, David E J Waddington, David J Reilly
The widespread use of nanodiamond as a biomedical platform for drug-delivery, imaging, and subcellular tracking applications stems from its nontoxicity and unique quantum mechanical properties. Here, we extend this functionality to the domain of magnetic resonance, by demonstrating that the intrinsic electron spins on the nanodiamond surface can be used to hyperpolarize adsorbed liquid compounds at low fields and room temperature. By combining relaxation measurements with hyperpolarization, spins on the surface of the nanodiamond can be distinguished from those in the bulk liquid...
December 23, 2016: Journal of the American Chemical Society
Anna Lichota, Anita Krokosz
Malignant tumors are one of the main causes of death in Poland. One of the objectives of contemporary biomedical research is to maximize the effects of therapeutic strategies. The actions undertaken to improve therapeutic agents are aimed at reducing the side effects of cancer treatments. Another direction of investigations is the search for protective substances that reduce the toxicity of the drug to normal cells. Carbon-based nanomaterials (fullerenes and their derivatives, graphene, carbon nanotubes, nanodiamonds) are a broad class of nanoparticles that have potential biomedical applications in both therapy and diagnostics...
December 22, 2016: Medycyna Pracy
Weixin Hou, Tan Boon Toh, Lissa Nurrul Abdullah, Tay Wei Zheng Yvonne, Kuan J Lee, Ilonka Guenther, Edward Kai-Hua Chow
Contrast agent-enhanced magnetic resonance (MR) imaging is critical for the diagnosis and monitoring of a number of diseases, including cancer. Certain clinical applications, including the detection of liver tumors, rely on both T1 and T2-weighted images even though contrast agent-enhanced MR imaging is not always reliable. Thus, there is a need for improved dual mode contrast agents with enhanced sensitivity. We report the development of a nanodiamond-manganese dual mode contrast agent that enhanced both T1 and T2-weighted MR imaging...
December 18, 2016: Nanomedicine: Nanotechnology, Biology, and Medicine
Lorena P Suarez-Kelly, Amanda R Campbell, Isaac V Rampersaud, Ambika Bumb, Min S Wang, Jonathan P Butchar, Susheela Tridandapani, Lianbo Yu, Arfaan A Rampersaud, William E Carson
Fluorescent nanodiamonds (FNDs) are nontoxic, infinitely photostable, and emit fluorescence in the near infrared region. Natural killer (NK) cells and monocytes are part of the innate immune system and are crucial to the control of carcinogenesis. FND-mediated stimulation of these cells may serve as a strategy to enhance anti-tumor activity. FNDs were fabricated with a diameter of 70±28 nm. Innate immune cell FND uptake, viability, surface marker expression, and cytokine production were evaluated in vitro...
December 18, 2016: Nanomedicine: Nanotechnology, Biology, and Medicine
Mona H C Biermann, Malgorzata J Podolska, Jasmin Knopf, Christiane Reinwald, Daniela Weidner, Christian Maueröder, Jonas Hahn, Deborah Kienhöfer, Alexandre Barras, Rabah Boukherroub, Sabine Szunerits, Rostyslav Bilyy, Markus Hoffmann, Yi Zhao, Georg Schett, Martin Herrmann, Luis E Munoz
Necrosis is associated with a profound inflammatory response. The regulation of necrosis-associated inflammation, particularly the mechanisms responsible for resolution of inflammation is incompletely characterized. Nanoparticles are known to induce plasma membrane damage and necrosis followed by sterile inflammation. We observed that injection of metabolically inert nanodiamonds resulted in paw edema in WT and Ncf1** mice. However, while inflammation quickly resolved in WT mice, it persisted over several weeks in Ncf1** mice indicating failure of resolution of inflammation...
2016: Frontiers in Immunology
Nikhil Rammohan, Keith W MacRenaris, Laura K Moore, Giacomo Parigi, Daniel J Mastarone, Lisa M Manus, Laura M Lilley, Adam T Preslar, Emily A Waters, Abigail Filicko, Claudio Luchinat, Dean Ho, Thomas J Meade
The ability to track labeled cancer cells in vivo would allow researchers to study their distribution, growth, and metastatic potential within the intact organism. Magnetic resonance (MR) imaging is invaluable for tracking cancer cells in vivo as it benefits from high spatial resolution and the absence of ionizing radiation. However, many MR contrast agents (CAs) required to label cells either do not significantly accumulate in cells or are not biologically compatible for translational studies. We have developed carbon-based nanodiamond-gadolinium(III) aggregates (NDG) for MR imaging that demonstrated remarkable properties for cell tracking in vivo...
December 14, 2016: Nano Letters
P Reineck, M Capelli, D W M Lau, J Jeske, M R Field, T Ohshima, A D Greentree, B C Gibson
Bright and photostable fluorescence from nitrogen-vacancy (NV) centers is demonstrated in unprocessed detonation nanodiamond particle aggregates. The optical properties of these particles is analyzed using confocal fluorescence microscopy and spectroscopy, time resolved fluorescence decay measurements, and optically detected magnetic resonance experiments. Two particle populations with distinct optical properties are identified and compared to high-pressure high-temperature (HPHT) fluorescent nanodiamonds. We find that the brightness of one detonation nanodiamond particle population is on the same order as that of highly processed fluorescent 100 nm HPHT nanodiamonds...
December 12, 2016: Nanoscale
Min-Chul Kim, Dukhee Lee, Seong Hoon Jeong, Sang-Yup Lee, Eunah Kang
Novel nanodiamond-gold nanocomposites (NDAus) are prepared, and their oxidative catalytic activity is examined. Gold nanoparticles are deposited on carboxylated nanodiamonds (NDs) by in situ chemical reduction of gold precursor ions to produce NDAus, which exhibit catalytic activity for the oxidation of o-phenylenediamine in the presence of hydrogen peroxide similarly to a peroxidase. This remarkable catalytic activity is exhibited only by the gold nanoparticle-decorated NDs and is not observed for either Au nanoparticles or NDs separately...
December 21, 2016: ACS Applied Materials & Interfaces
Stepan Stehlik, Marian Varga, Martin Ledinsky, Daria Miliaieva, Halyna Kozak, Viera Skakalova, Clemens Mangler, Timothy J Pennycook, Jannik C Meyer, Alexander Kromka, Bohuslav Rezek
Detonation nanodiamonds (DNDs) with a typical size of 5 nm have attracted broad interest in science and technology. Further size reduction of DNDs would bring these nanoparticles to the molecular-size level and open new prospects for research and applications in various fields, ranging from quantum physics to biomedicine. Here we show a controllable size reduction of the DND mean size down to 1.4 nm without significant particle loss and with additional disintegration of DND core agglutinates by air annealing, leading to a significantly narrowed size distribution (±0...
December 2, 2016: Scientific Reports
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