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https://www.readbyqxmd.com/read/28795398/robust-fluorescent-labelling-of-micropipettes-for-use-in-fluorescence-microscopy-application-to-the-observation-of-a-mosquito-borne-parasite-infection
#1
Amanda E Balaban, Keir Neuman, Photini Sinnis, Robert S Balaban
The ability to monitor micropipette injections with a high-resolution fluorescent microscope has utility for a variety of applications. Herein, different approaches were tested for creating broad-band fluorescently labelled glass micropipettes including: UV cured glass glues, baked glass enamel containing fluorescent dyes as well as nanodiamonds attached during pipette formation in the microforge. The most robust and simplest approach was to use labelled baked enamel on the exterior of the pipette. This approach was tested using pipettes designed to mimic a mosquito proboscis for the injection of the malaria parasite, Plasmodium spp...
August 10, 2017: Journal of Microscopy
https://www.readbyqxmd.com/read/28793776/water-adsorption-property-of-hierarchically-nanoporous-detonation-nanodiamonds
#2
Elda-Zoraida Pina-Salazar, Koki Urita, Takuya Hayashi, Ryusuke Futamura, Fernando Vallejos-Burgos, Jerzy Włoch, Piotr Kowalczyk, Marek Wiśniewski, Toshio Sakai, Isamu Moriguchi, Artur Piotr Terzyk, Eiji Osawa, Katsumi Kaneko
The detonation nanodiamonds form the aggregate having interparticle voids, giving a marked hygroscopic property. As the relationship between pore structure and water adsorption of aggregated nanodiamonds is not well understood yet, adsorption isotherms of N2 at 77 K and of water vapor at 298 K of the well-characterized aggregated nanodiamonds were measured. HR-TEM and X-ray diffraction showed that the nanodiamonds were highly crystalline and their average crystallite size was 4.5 nm. The presence of the graphitic layers on the nanodiamond particle surface was confirmed by the EELS examination...
August 9, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28772710/haemocompatibility-of-modified-nanodiamonds
#3
Michał Wąsowicz, Mateusz Ficek, Maciej S Wróbel, Ruchira Chakraborty, Dror Fixler, Paweł Wierzba, Małgorzata Jędrzejewska-Szczerska
This study reports the interactions of modified nanodiamond particles in vitro with human blood. Modifications performed on the nanodiamond particles include oxygenation with a chemical method and hydrogenation upon chemical vapor deposition (CVD) plasma treatment. Such nanodiamonds were later incubated in whole human blood for different time intervals, ranging from 5 min to 5 h. The morphology of red blood cells was assessed along with spectral measurements and determination of haemolysis. The results showed that no more than 3% of cells were affected by the nanodiamonds...
March 28, 2017: Materials
https://www.readbyqxmd.com/read/28765598/synthesis-and-multi-scale-tribological-behavior-of-wc-co-nanodiamond-nanocomposites
#4
Andy Nieto, Lin Jiang, Jaekang Kim, Dae-Eun Kim, Julie M Schoenung
Nanodiamonds (ND) present a unique combination of desirable mechanical, functional, and chemical characteristics that are ideally suited for reinforcing and enhancing the wear resistance of carbide based materials. Tungsten carbide cobalt (WC-Co) matrix nanocomposites reinforced with varying amounts of ND (2 - 10 vol.%) were synthesized here by spark plasma sintering. The rapid thermal consolidation route enabled attainment of dense samples with a significant retention of the metastable diamond phase. NDs affected the microstructural evolution, chemistry, and mechanical properties of WC-Co...
August 1, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28762520/nanomaterials-as-stationary-phases-and-supports-in-liquid-chromatography
#5
REVIEW
Sandya R Beeram, Elliott Rodriguez, Suresh Doddavenkatanna, Zhao Li, Allegra Pekarek, Darin Peev, Kathryn Goerl, Gianfranco Trovato, Tino Hofmann, David S Hage
The development of various nanomaterials over the last few decades has led to many applications for these materials in liquid chromatography (LC). This review will look at the types of nanomaterials that have been incorporated into LC systems and the applications that have been explored for such systems. A number of carbon-based nanomaterials and inorganic nanomaterials have been considered for use in LC, ranging from carbon nanotubes, fullerenes and nanodiamonds to metal nanoparticles and nanostructures based on silica, alumina, zirconia and titanium dioxide...
August 1, 2017: Electrophoresis
https://www.readbyqxmd.com/read/28756321/enhanced-nucleation-of-diamond-on-three-dimensional-tools-via-stabilized-colloidal-nanodiamond-in-electrostatic-self-assembly-seeding-process
#6
Tao Wang, Stephan Handschuh-Wang, Songquan Zhang, Xuechang Zhou, Yongbing Tang
Nanocrystalline diamond particles are promising candidates for copious applications in materials science, biology and electronics. In this work, diamond nucleation density was unprecedentedly enhanced via a non-invasive electrostatic self-assembly seeding approach. By addition of glutamic acid to the nanodiamond seeding solution, the positively charged amino-group of glutamic acid, which is adsorbed on nanodiamond particles, enhances the adsorption on negative charged cemented carbide substrate. The highest nucleation density (1...
July 11, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28754039/nanodiamond-chymotrypsin-and-nanodiamond-papain-conjugates-their-synthesis-and-activity-and-visualization-of-their-interaction-with-cells-using-optical-and-electron-microscopy
#7
Sergey A Golyshev, Anna K Berkovich, Ruslan Yu Yakovlev, Dmitry M Bystrov, Nikita M Ivanov, Galina N Balandina, Galina N Rudenskaya
Two novel conjugates of detonation nanodiamonds (dNDs) with the proteolytic enzymes chymotrypsin and papain were synthesized. The synthesis was performed via functionalization of the dNDs' surface with acidic/alkali treatment followed by carbodiimide-mediated protein binding. Covalent binding of the enzymes was confirmed by Fourier transform infrared spectrographic analysis and high-performance liquid chromatography (HPLC) amino acid analysis. HPLC also proved the preservation of the enzymes' composition during synthesis...
July 28, 2017: Biointerphases
https://www.readbyqxmd.com/read/28747768/controlling-adult-stem-cell-behavior-using-nanodiamond-reinforced-hydrogel-implication-in-bone-regeneration-therapy
#8
Settimio Pacelli, Ryan Maloney, Aparna R Chakravarti, Jonathan Whitlow, Sayantani Basu, Saman Modaresi, Stevin Gehrke, Arghya Paul
Nanodiamonds (NDs) have attracted considerable attention as drug delivery nanocarriers due to their low cytotoxicity and facile surface functionalization. Given these features, NDs have been recently investigated for the fabrication of nanocomposite hydrogels for tissue engineering. Here we report the synthesis of a hydrogel using photocrosslinkable gelatin methacrylamide (GelMA) and NDs as a three-dimensional scaffold for drug delivery and stem cell-guided bone regeneration. We investigated the effect of different concentration of NDs on the physical and mechanical properties of the GelMA hydrogel network...
July 26, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28741141/detonation-nanodiamonds-are-promising-nontoxic-delivery-system-for-urothelial-cells
#9
Daša Zupančič, Mateja Erdani Kreft, Maja Grdadolnik, Dimitar Mitev, Aleš Iglič, Peter Veranič
Detonation nanodiamonds (DNDs) are carbon-based nanomaterials that are among the most promising nanoparticles available for biomedical applications so far. This is due to their biocompatibility, which could be contributed to their inert core and conformable surface nature. However, DNDs cytotoxicity for urothelial cells and the routes of their internalization remains an open question in the aspect of nanodiamond surface. We therefore analyzed four types of DNDs for cytotoxicity and internalization with normal urothelial cells and two types of cancer urothelial cell lines in vitro...
July 24, 2017: Protoplasma
https://www.readbyqxmd.com/read/28724919/generally-applicable-transformation-protocols-for-fluorescent-nanodiamond-internalization-into-cells
#10
Simon R Hemelaar, Kiran J van der Laan, Sophie R Hinterding, Manon V Koot, Else Ellermann, Felipe P Perona-Martinez, David Roig, Severin Hommelet, Daniele Novarina, Hiroki Takahashi, Michael Chang, Romana Schirhagl
Fluorescent nanodiamonds (FNDs) are promising nanoprobes, owing to their stable and magnetosensitive fluorescence. Therefore they can probe properties as magnetic resonances, pressure, temperature or strain. The unprecedented sensitivity of diamond defects can detect the faint magnetic resonance of a single electron or even a few nuclear spins. However, these sensitivities are only achieved if the diamond probe is close to the molecules that need to be detected. In order to utilize its full potential for biological applications, the diamond particle has to enter the cell...
July 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28665485/efficient-and-highly-selective-solvent-free-oxidation-of-primary-alcohols-to-aldehydes-using-bucky-nanodiamond
#11
Yangming Lin, Kuang-Hsu Tim Wu, Linhui Yu, Saskia Heumann, Dangsheng Su
Selective oxidation of alcohols to aldehydes is widely applicable to the synthesis of various green chemicals. The poor chemo-selectivity for complicated primary aldehydes over state-of-the-art metal-free or metal-based catalysts represents a major obstacle for industrial application. Here we report on bucky nanodiamond as a potential green catalyst which exhibits excellent chemo-selectivity and cycle stability in the selective oxidation of primary alcohols in diverse structures (22 examples, including aromatic, substituted aromatic, unsaturated, heterocycle and linear chain alcohols) to their corresponding aldehydes; the results are even comparable to the reported transition metal catalysts and conventional Pt/C and Ru/C catalysts for certain substrates under solvent-free conditions...
June 30, 2017: ChemSusChem
https://www.readbyqxmd.com/read/28646193/fabrication-of-nitrogen-doped-nano-onions-and-their-electrocatalytic-activity-toward-the-oxygen-reduction-reaction
#12
E Y Choi, C K Kim
Nitrogen-doped nano-onions (NNO) were prepared as electrocatalytic materials for the oxygen reduction reaction (ORR). The nano-onions (NO), spherical graphitic material particles, were prepared by pyrolysis of nanodiamonds (ND). Oxidized NO (ONO) was prepared from NO by a modified Hummers' method, and this was mixed with urea, followed by pyrolysis, resulting in the formation of NNO. The nitrogen content and molar ratio of nitrogen-containing groups in the NNOs were varied by controlling the oxygen content of ONO to explore the effect of nitrogen content on the ORR activity...
June 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28636640/targeted-nanodiamonds-for-identification-of-subcellular-protein-assemblies-in-mammalian-cells
#13
Michael P Lake, Louis-S Bouchard
Transmission electron microscopy (TEM) can be used to successfully determine the structures of proteins. However, such studies are typically done ex situ after extraction of the protein from the cellular environment. Here we describe an application for nanodiamonds as targeted intensity contrast labels in biological TEM, using the nuclear pore complex (NPC) as a model macroassembly. We demonstrate that delivery of antibody-conjugated nanodiamonds to live mammalian cells using maltotriose-conjugated polypropylenimine dendrimers results in efficient localization of nanodiamonds to the intended cellular target...
2017: PloS One
https://www.readbyqxmd.com/read/28635183/cetuximab-conjugated-nanodiamonds-drug-delivery-system-for-enhanced-targeting-therapy-and-3d-raman-imaging
#14
Dandan Li, Xin Chen, Hong Wang, Jie Liu, Meiling Zheng, Yang Fu, Yuan Yu, Jinfang Zhi
In this study, a multicomponent nanodiamonds (NDs)-based targeting drug delivery system, cetuximab-NDs-cisplatin bioconjugate, combining both specific targeting and enhanced therapeutic efficacy capabilities, is developed and characterized. The specific targeting ability of cetuximab-NDs-cisplatin system on human liver hepatocellular carcinoma (HepG2) cells is evaluated through epidermal growth factor receptor (EGFR) blocking experiments, since EGFR is over-expressed on HepG2 cell membrane. Besides, cytotoxic evaluation confirms that cetuximab-NDs-cisplatin system could significantly inhibit the growth of HepG2 cells, and the therapeutic activity of this system is proven to be better than that of both nonspecific NDs-cisplatin conjugate and specific EGF-NDs-cisplatin conjugate...
June 21, 2017: Journal of Biophotonics
https://www.readbyqxmd.com/read/28605070/nanodiamonds-that-swim
#15
Ji Tae Kim, Udit Choudhury, Hyeon-Ho Jeong, Peer Fischer
Nanodiamonds are emerging as nanoscale quantum probes for bio-sensing and imaging. This necessitates the development of new methods to accurately manipulate their position and orientation in aqueous solutions. The realization of an "active" nanodiamond (ND) swimmer in fluids, composed of a ND crystal containing nitrogen vacancy centers and a light-driven self-thermophoretic micromotor, is reported. The swimmer is propelled by a local temperature gradient created by laser illumination on its metal-coated side...
August 2017: Advanced Materials
https://www.readbyqxmd.com/read/28602087/nanodiamonds-as-nucleating-agents-for-protein-crystallization
#16
Yen-Wei Chen, Chien-Hsun Lee, Yung-Lin Wang, Tsung-Lin Li, Huan-Cheng Chang
Nanodiamond (ND) is a carbon-based nanomaterial with potential for a wide range of biological applications. One of such applications is to facilitate the nucleation of protein crystals in aqueous solution. Here, we show that NDs (nominal diameters of 30 and 100 nm) after surface oxidation in air and subsequent treatment in strong acids are useful as heterogeneous nucleating agents for protein crystallization. Tested with lysozyme, ribonuclease A, proteinase K, and catalase, the nanomaterials in either aggregate or film form are found to be able to increase the crystallization efficiency of all proteins...
June 21, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28601788/carbon-nanostructures-as-immobilization-platform-for-dna-a-review-on-current-progress-in-electrochemical-dna-sensors
#17
REVIEW
P Abdul Rasheed, N Sandhyarani
Development of a sensitive, specific and cost-effective DNA detection method is motivated by increasing demand for the early stage diagnosis of genetic diseases. Recent developments in the design and fabrication of efficient sensor platforms based on nanostructures make the highly sensitive sensors which could indicate very low detection limit to the level of few molecules, a realistic possibility. Electrochemical detection methods are widely used in DNA diagnostics as it provide simple, accurate and inexpensive platform for DNA detection...
June 8, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28596105/multifunctional-nanodiamonds-in-regenerative-medicine-recent-advances-and-future-directions
#18
REVIEW
Jonathan Whitlow, Settimio Pacelli, Arghya Paul
With recent advances in the field of nanomedicine, many new strategies have emerged for diagnosing and treating diseases. At the forefront of this multidisciplinary research, carbon nanomaterials have demonstrated unprecedented potential for a variety of regenerative medicine applications including novel drug delivery platforms that facilitate the localized and sustained release of therapeutics. Nanodiamonds (NDs) are a unique class of carbon nanoparticles that are gaining increasing attention for their biocompatibility, highly functional surfaces, optical properties, and robust physical properties...
September 10, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28553109/bitistatin-functionalized-fluorescent-nanodiamond-particles-specifically-bind-to-purified-human-platelet-integrin-receptor-%C3%AE-iib%C3%AE-3-and-activated-platelets
#19
Cezary Marcinkiewicz, Jonathan A Gerstenhaber, Mark Sternberg, Peter I Lelkes, Giora Feuerstein
Thromboembolic events (TEE) underwrite key causes of death in developed countries. While advanced imaging technologies such as computed tomography scans serve to diagnose blood clots during acute cardiovascular events, no such technology is available in routine primary care for TEE risk assessment. Here, we describe an imaging platform technology based on bioengineered fluorescent nanodiamond particles (F-NDPs) functionalized with bitistatin (Bit), a disintegrin that specifically binds to the αIIbβ3 integrin, platelet fibrinogen receptor (PFR) on activated platelets...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28548489/glycosaminoglycans-specific-cell-targeting-and-imaging-using-fluorescent-nanodiamonds-coated-with-viral-envelope-proteins
#20
Minh D Pham, Chandra Prakash Epperla, Chia-Lung Hsieh, Wen Chang, Huan-Cheng Chang
Understanding virus-host interactions is crucial for vaccine development. This study investigates such interactions using fluorescent nanodiamonds (FNDs) coated with vaccinia envelope proteins as the model system. To achieve this goal, we noncovalently conjugated 100 nm FNDs with rA27(aa 21-84), a recombinant envelope protein of vaccinia virus, for glycosaminoglycans (GAGs)-specific targeting and imaging of living cells. Another recombinant protein rDA27(aa 33-84) that removes the GAGs-binding sequences was also used for comparison...
June 8, 2017: Analytical Chemistry
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