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Paroxysmal atrial fibrillation

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https://www.readbyqxmd.com/read/28340073/left-atrial-appendage-isolation-in-addition-to-pulmonary-vein-isolation-in-persistent-atrial-fibrillation-one-year-clinical-outcome-after-cryoballoon-based-ablation
#1
Hikmet Yorgun, Ugur Canpolat, Duygu Kocyigit, Cem Çöteli, Banu Evranos, Kudret Aytemir
Aims: In this study, we sought to evaluate the safety and efficacy of cryoballoon (CB) based empirical left atrial appendage (LAA) isolation as an adjunct to pulmonary vein isolation (PVI) compared to the PVI-only strategy in patients with persistent AF. Objectives: Clinical outcomes of catheter ablation were less beneficial for persistent atrial fibrillation (AF) than paroxysmal AF. Methods and results: A total of 100 consecutive patients with persistent AF underwent both PVI and additional LAA isolation using CB (Group II)...
March 9, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28340057/long-term-outcome-of-pulmonary-vein-isolation-in-patients-with-paroxysmal-atrial-fibrillation-and-brugada-syndrome
#2
Giacomo Mugnai, Burak Hünük, Erwin Ströker, Diego Ruggiero, Hugo Enrique Coutino-Moreno, Ken Takarada, Valentina De Regibus, Rajin Choudhury, Juan Pablo Abugattas de Torres, Darragh Moran, Saverio Iacopino, Pasquale Filannino, Giulio Conte, Juan Sieira, Jan Poelaert, Stefan Beckers, Pedro Brugada, Carlo de Asmundis, Gian-Battista Chierchia
Aims: The therapeutical management of atrial fibrillation (AF) in the setting of Brugada syndrome (BS) might be challenging as many antiarrhythmic drugs (AADs) with sodium channel blocking properties might lead to to the development of ventricular arrhythmias. This study sought to evaluate the clinical outcome in a consecutive series of patients with BS having undergone pulmonary vein (PV) isolation by means of radiofrequency (RF) or cryoballoon (CB) ablation and the efficacy of catheter ablation for preventing inappropriate interventions delivered by implantable cardioverter defibrillators (ICD) on a 3-year follow up...
March 9, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28340043/very-long-term-outcome-following-transcatheter-ablation-of-atrial-fibrillation-are-results-maintained-after-10-years-of-follow-up
#3
Fiorenzo Gaita, Marco Scaglione, Alberto Battaglia, Mario Matta, Cristina Gallo, Michela Galatà, Domenico Caponi, Paolo Di Donna, Matteo Anselmino
Aims: Atrial fibrillation (AF) transcatheter ablation is a safe and effective procedure. However, outcome over 10 years of follow-up has never been reported. The aim of this study is to assess outcome, describe predictors of recurrences, and report on quality of life (QoL) the decade after an AF ablation. Methods and results: Patients referred for AF ablation in a single high volume centre from June 2004 to June 2006 were enrolled and followed in a prospective fashion by yearly clinical assessment and Holter monitoring...
February 28, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28339804/intra-cardiac-and-peripheral-levels-of-biochemical-markers-of-fibrosis-in-patients-undergoing-catheter-ablation-for-atrial-fibrillation
#4
Gordon A Begg, Rashed Karim, Tobias Oesterlein, Lee N Graham, Andrew J Hogarth, Stephen P Page, Christopher B Pepper, Kawal Rhode, Gregory Y H Lip, Arun V Holden, Sven Plein, Muzahir H Tayebjee
Aims: Measurement of circulating biomarkers of fibrosis may have a role in selecting patients and treatment strategy for catheter ablation. Pro-collagen type III N-terminal pro-peptide (PIIINP), C-telopeptide of type I collagen (ICTP), fibroblast growth factor 23 (FGF-23), and galectin 3 (gal-3) have all been suggested as possible biomarkers for this indication, but studies assessing whether peripheral levels reflect intra-cardiac levels are scarce. Methods and results: We studied 93 patients undergoing ablation for paroxysmal atrial fibrillation (AF) (n = 63) or non-paroxysmal AF (n = 30)...
February 27, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28339601/characterization-and-consistency-of-interactions-of-triggers-and-substrate-at-the-onset-of-paroxysmal-atrial-fibrillation
#5
David G Jones, Vias Markides, Anthony W C Chow, Richard J Schilling, Prapa Kanagaratnam, Tom Wong, D Wyn Davies, Nicholas S Peters
Aims: Initiating mechanisms of atrial fibrillation (AF) remain poorly understood, involving complex interaction between triggers and the atrial substrate. This study sought to classify the transitional phenomena, hypothesizing that there is consistency within and between patients in trigger-substrate interaction during transition to AF. Methods and results: Non-contact left atrial (LA) mapping was performed in 17 patients undergoing ablation for paroxysmal AF. All had spontaneous ectopy...
January 25, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28339554/efficacy-and-safety-of-antazoline-in-the-rapid-cardioversion-of-paroxysmal-atrial-fibrillation-the-anpaf-study
#6
Aleksander Maciag, Michal M Farkowski, Tomasz Chwyczko, Maciej Beckowski, Pawel Syska, Ilona Kowalik, Mariusz Pytkowski, Jacek Wozniak, Rafal Dabrowski, Hanna Szwed
Aims: The aim of the study was to assess the clinical efficacy of antazoline, a first-generation anti-histaminic agent, in the rapid conversion of paroxysmal non-valvular atrial fibrillation (AF) to sinus rhythm in patients without heart failure. Methods and results: This study was a single center, randomized, double blind, placebo-controlled, superiority clinical trial. We enrolled patients with an AF episode lasting less than 43 h, in stable cardiopulmonary condition...
December 22, 2016: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28339545/left-atrial-anatomy-atrial-fibrillation-burden-and-p-wave-duration-relationships-and-predictors-for-single-procedure-success-after-pulmonary-vein-isolation
#7
Sven Knecht, Maurice Pradella, Tobias Reichlin, Aline Mühl, Matthias Bossard, Bram Stieltjes, David Conen, Jens Bremerich, Stefan Osswald, Michael Kühne, Christian Sticherling
Aims: Atrial fibrillation (AF) is associated with changes in left atrial (LA) volume, but the relationship between LA size, AF burden, and electrical conduction behaviour is still uncertain. The aim of this study was to quantify the association and impact of these parameters on the single-procedure outcome after circumferential antral ablation for pulmonary vein isolation. Methods and results: Left atrial assessment was performed in 129 consecutive patients using pre-procedural imaging in three dimensions (sphericity, indexed volume), two dimensions (diameters), and from echocardiography in one dimension (long axis)...
December 22, 2016: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28332202/calcium-signalling-silencing-in-atrial-fibrillation
#8
Maura Greiser
Sub-cellular calcium signalling silencing is a novel and distinct cellular and molecular adaptive response to rapid cardiac activation. Calcium signalling silencing develops during short-term sustained rapid atrial activation as seen clinically during paroxysmal atrial fibrillation (AF). It is the first 'anti-arrhythmic' adaptive response in the setting of AF and appears to counteract the maladaptive changes that lead to intracellular Ca(2+) signalling instability and Ca(2+) based arrhythmogenicity. Calcium signalling silencing results in a failed propagation of the [Ca(2+) ]i signal to the myocyte centre in both patients with AF and in a rabbit model...
March 22, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28321025/one-year-success-rate-of-pulmonary-vein-isolation-using-a-novel-irrigated-multipolar-mapping-and-ablation-catheter-with-reduced-power-settings
#9
Dong-In Shin, Jan-Erik Guelker, Christian Blockhaus, Jan Schmidt, Muhammed Kurt, Lukas Clasen, Patrick Mueller, Lars Bansemir, Christoph Brinkmeyer, Alexander Bufe, Malte Kelm, Hisaki Makimoto
The use of a novel irrigated multipolar ablation and mapping catheter for pulmonary vein isolation in patients with atrial fibrillation (AF) has demonstrated reasonable acute success rates and short procedure times, however, long-term outcome data are limited. The aim of this study was to analyze the long-term efficacy of this novel ablation system utilizing a reduced power setting for safety purposes.A total of 89 patients with paroxysmal (63 of 89 patients; 71%) or persistent AF underwent PVI with a reduced power setting of maximum 20 Watts (W) unipolar radiofrequency energy and 30 seconds in duration...
March 17, 2017: International Heart Journal
https://www.readbyqxmd.com/read/28320990/comorbidities-and-complications-in-nonagenarians-undergoing-coronary-angiography-and-intervention
#10
Mohamed Gayed, Nour Yadak, Waad Qamhia, Yunis Daralammouri, Marc-Alexander Ohlow
Elderly people represent the fastest growing portion of cardiovascular patients. We aimed to analyze the clinical presentation, risk factors, co-morbidities, complications, and mortality in patients 90 years or more who underwent coronary angiography and intervention.We retrospectively studied 108 (0.25% of 43,385) consecutive patients ≥ 90 years undergoing cardiac catheterization and/or intervention in a tertiary specialist hospital between 2003 and 2014.Most patients (68.5%) were introduced on an emergency basis, especially with acute coronary syndrome (ACS) (63...
March 21, 2017: International Heart Journal
https://www.readbyqxmd.com/read/28317415/uninterrupted-dabigatran-versus-warfarin-for-ablation-in-atrial-fibrillation
#11
Hugh Calkins, Stephan Willems, Edward P Gerstenfeld, Atul Verma, Richard Schilling, Stefan H Hohnloser, Ken Okumura, Harvey Serota, Matias Nordaby, Kelly Guiver, Branislav Biss, Marc A Brouwer, Massimo Grimaldi
Background Catheter ablation of atrial fibrillation is typically performed with uninterrupted anticoagulation with warfarin or interrupted non-vitamin K antagonist oral anticoagulant therapy. Uninterrupted anticoagulation with a non-vitamin K antagonist oral anticoagulant, such as dabigatran, may be safer; however, controlled data are lacking. We investigated the safety of uninterrupted dabigatran versus warfarin in patients undergoing ablation of atrial fibrillation. Methods In this randomized, open-label, multicenter, controlled trial with blinded adjudicated end-point assessments, we randomly assigned patients scheduled for catheter ablation of paroxysmal or persistent atrial fibrillation to receive either dabigatran (150 mg twice daily) or warfarin (target international normalized ratio, 2...
March 19, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28315135/repeat-procedures-using-the-second-generation-cryoballoon-for-recurrence-of-atrial-fibrillation-after-initial-ablation-with-conventional-radiofrequency
#12
Valentina De Regibus, Saverio Iacopino, Juan-Pablo Abugattas, Giacomo Mugnai, Darragh Moran, Erwin Ströker, Hugo-Enrique Coutino, Ken Takarada, Rajin Choudhury, Gaetano Paparella, Vincent Umbrain, Pedro Brugada, Carlo de Asmundis, Gian-Battista Chierchia
PURPOSE: Pulmonary vein isolation is now widely accepted for the treatment of symptomatic atrial fibrillation refractory to antiarrhythmic drugs. However, multiple procedures are often required to significantly reduce atrial fibrillation (AF) recurrence. In the present study, we analyzed the acute results and the midterm clinical outcome of a second-generation cryoballoon ablation (CB-A) performed during repeat procedures for recurrence of AF after an initial procedure performed with conventional radiofrequency (RF)...
March 17, 2017: Journal of Interventional Cardiac Electrophysiology: An International Journal of Arrhythmias and Pacing
https://www.readbyqxmd.com/read/28302997/platelets-cellular-and-functional-characteristics-in-patients-with-atrial-fibrillation-a-comprehensive-meta-analysis-and-systematic-review
#13
Alexander Weymann, Sadeq Ali-Hasan-Al-Saegh, Anton Sabashnikov, Aron-Frederik Popov, Seyed Jalil Mirhosseini, Luis Nombela-Franco, Luca Testa, Mohammadreza Lotfaliani, Mohamed Zeriouh, Tong Liu, Hamidreza Dehghan, Senol Yavuz, Michel Pompeu Barros de Oliveira Sá, William L Baker, Jae-Sik Jang, Mengqi Gong, Umberto Benedetto, Pascal M Dohmen, Fabrizio D'Ascenzo, Abhishek J Deshmukh, Giuseppe Biondi-Zoccai, Hugh Calkins, Gregg W Stone, Integrated Meta-Analysis Of Cardiac Surgery And Cardiology-Group Imcsc-Group
BACKGROUND This systematic review with meta-analysis aimed to determine the strength of evidence for evaluating the association of platelet cellular and functional characteristics including platelet count (PC), MPV, platelet distribution width (PDW), platelet factor 4, beta thromboglobulin (BTG), and p-selectin with the occurrence of atrial fibrillation (AF) and consequent stroke. MATERIAL AND METHODS We conducted a meta-analysis of observational studies evaluating platelet characteristics in patients with paroxysmal, persistent and permanent atrial fibrillations...
March 17, 2017: Medical Science Monitor Basic Research
https://www.readbyqxmd.com/read/28301685/conventional-versus-3d-echocardiography-to-predict-arrhythmia-recurrence-after-atrial-fibrillation-ablation
#14
Matthias Bossard, Sven Knecht, Stefanie Aeschbacher, Ronny R Buechel, Thomas Hochgruber, Andreas J Zimmermann, Arnheid Kessel-Schaefer, Frank-Peter Stephan, Gian Völlmin, Maurice Pradella, Christian Sticherling, Stefan Osswald, Beat A Kaufmann, David Conen, Michael Kühne
BACKGROUND: Arrhythmia recurrence after atrial fibrillation (AF) ablation remains high and requires repeat interventions in a substantial number of patients. We assessed the value of conventional and 3D-echocardiography to predict AF recurrence. METHODS AND RESULTS: Consecutive patients undergoing AF ablation by means of pulmonary vein isolation were included in a prospective registry. Echocardiograms were obtained prior to the ablation procedure, and analyzed offline in a standardized manner, including 3D-left atrial (LA) volumetry and determination of LA function and sphericity...
March 16, 2017: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/28297123/embolization-of-watchman-device-following-a-hybrid-radiofrequency-ablation-of-atrial-fibrillation-and-watchman-implantation-procedure
#15
James Gabriels, Stuart Beldner, Mohammad Khan, Jonah Zeitlin, Ram Jadonath, Apoor Patel
A 24-year-old man with a history of type 1 diabetes mellitus, an ischemic left middle cerebral artery stroke and atrial flutter with a prior ablation was found to have paroxysmal atrial fibrillation (AF) on an implantable loop recorder. He was encouraged to continue anticoagulation with apixaban (CHA2 DS2 -VASc: 3). This article is protected by copyright. All rights reserved.
March 15, 2017: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/28296811/new-onset-atrial-fibrillation-in-the-critically-ill
#16
Travis J Moss, James Forrest Calland, Kyle B Enfield, Diana C Gomez-Manjarres, Caroline Ruminski, John P DiMarco, Douglas E Lake, J Randall Moorman
OBJECTIVE: To determine the association of new-onset atrial fibrillation with outcomes, including ICU length of stay and survival. DESIGN: Retrospective cohort of ICU admissions. We found atrial fibrillation using automated detection (≥ 90s in 30 min) and classed as new-onset if there was no prior diagnosis of atrial fibrillation. We identified determinants of new-onset atrial fibrillation and, using propensity matching, characterized its impact on outcomes. SETTING: Tertiary care academic center...
March 14, 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/28296023/closure-of-patent-forman-ovale-defects-using-gore%C3%A2-cardioform-septal-occluder
#17
Stefan E Hardt, Andreas Eicken, Felix Berger, Stephan Schubert, Mario Carminati, Gianfranco Butera, Jochen Grohmann, Rene Höhn, Jens Erik Nielsen-Kudsk, David Hildick-Smith, Magnus Settergren, John D Thomson, Nicolas Geis, Lars Søndergaard
AIMS: The GORE® CARDIOFORM Septal Occluder (GSO) is a novel device designed for rapid and effective closure of patent foramen ovale (PFO) which has distinctive features making it suitable for a broad spectrum of anatomical variations. We report the procedural and 6 months follow-up results of the first prospective, multicenter study using GSO. METHODS AND RESULTS: This single-arm study included 150 subjects undergoing closure of PFO in 10 European centers. In 149 out of 150 patients implantation of a GSO device was successful...
March 15, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28295425/prophylactic-atropine-administration-prevents-vasovagal-response-induced-by-cryoballoon-ablation-in-patients-with-atrial-fibrillation
#18
Liping Sun, Jian-Zeng Dong, Xin DU, Rong Bai, Songnan Li, Mohamed Salim, Chang-Sheng Ma
BACKGROUND: Cryoballoon ablation of pulmonary vein (PV) ostia often induces a vagal response.This prospective study was designed to assess the effectiveness of prophylactic intravenous administration of atropine on hemodynamic impairment induced by cryoballoon ablation in patients with atrial fibrillation. METHODS: Twenty-five patients with paroxysmal atrial fibrillation undergoing cryoballoon ablation were prospectively enrolled and assigned to one of two groups...
March 11, 2017: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/28294873/-prognostication-of-sinus-rhythm-restoration-during-paroxysm-of-atrial-fibrillation
#19
A V Muromkina, B A Ballod, O A Nazarova, O M Drapkina
No abstract text is available yet for this article.
May 2016: Kardiologiia
https://www.readbyqxmd.com/read/28290877/-dynamics-of-biochemical-markers-of-endothelial-dysfunction-in-patients-with-arterial-hypertension
#20
V I Podzolkov, A I Tarzimanova
Arterial hypertension (AH) occupies the first place among causes of atrial fibrillation (AF) in general population. AF in patients with AH substantially elevates risk of cardiovascular complications. Endothelial dysfunction (ED) in patients with AH at appearance of AF might have great prognostic value for stratification of risk of thromboembolic complications. We studied biochemical markers of ED in patients with AH and various forms of AF. Collagen binding activity of the von Willebrand factor (vWF) in patients with permanent AF was significantly higher than in patients without heart rhythm disturbances and did not depend on degree of AH...
August 2016: Kardiologiia
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