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https://www.readbyqxmd.com/read/28432532/a-portable-battery-powered-microfluidic-impedance-cytometer-with-smartphone-readout-towards-personal-health-monitoring
#1
Niloy Talukder, Abbas Furniturewalla, Tuan Le, Matthew Chan, Shreyas Hirday, Xinnan Cao, Pengfei Xie, Zhongtian Lin, Azam Gholizadeh, Steve Orbine, Mehdi Javanmard
We present a portable system for personalized blood cell counting consisting of a microfluidic impedance cytometer and portable analog readout electronics, feeding into an analog-to-digital converter (ADC), and being transmitted via Bluetooth to a user-accessible mobile application. We fabricated a microfluidic impedance cytometer with a novel portable analog readout. The novel design of the analog readout, which consists of a lock-in-amplifier followed by a high-pass filter stage for subtraction of drift and DC offset, and a post-subtraction high gain stage, enables detection of particles and cells as small as 1 μm in diameter, despite using a low-end 8-bit ADC...
June 2017: Biomedical Microdevices
https://www.readbyqxmd.com/read/28431025/1h-magnetic-resonance-spectroscopy-of-live-human-sperm
#2
S Reynolds, S J Calvert, M N Paley, A A Pacey
STUDY QUESTION: Can 1H Magnetic Resonance Spectroscopy (MRS) be used to obtain information about the molecules and metabolites in live human spermatozoa? SUMMARY ANSWER: Percoll-based density gradient centrifugation (DGC) followed by a further two washing steps, yielded enough sperm with minimal contamination (<0.01%) from seminal fluid to permit effective MRS which detected significant differences (p < 0.05) in the choline/glycerophosphocholine, lipid and lactate regions of the 1H MRS spectrum between sperm in the pellet and those from the 40/80% interface...
April 18, 2017: Molecular Human Reproduction
https://www.readbyqxmd.com/read/28430715/computed-tomography-of-the-head-and-neck-region-for-tumor-staging-comparison-of-dual-source-dual-energy-and-low-kilovolt-single-energy-acquisitions
#3
Matthias Stefan May, Joscha Bruegel, Michael Brand, Marco Wiesmueller, Bernhard Krauss, Thomas Allmendinger, Michael Uder, Wolfgang Wuest
PURPOSE: The aim of this study was to intra-individually compare the image quality obtained by dual-source, dual-energy (DSDE) computed tomography (CT) examinations and different virtual monoenergetic reconstructions to a low single-energy (SE) scan. MATERIALS AND METHODS: Third-generation DSDE-CT was performed in 49 patients with histologically proven malignant disease of the head and neck region. Weighted average images (WAIs) and virtual monoenergetic images (VMIs) for low (40 and 60 keV) and high (120 and 190 keV) energies were reconstructed...
April 20, 2017: Investigative Radiology
https://www.readbyqxmd.com/read/28430560/database-centric-method-for-automated-high-throughput-deconvolution-and-analysis-of-kinetic-antibody-screening-data
#4
R Paul Nobrega, Michael Brown, Cody Williams, Chris Sumner, Patricia Estep, Isabelle Caffry, Yao Yu, Heather Lynaugh, Irina Burnina, Asparouh Lilov, Jordan Desroches, John Bukowski, Tingwan Sun, Jonathan P Belk, Kirt Johnson, Yingda Xu
The state-of-the-art industrial drug discovery approach is the empirical interrogation of a library of drug candidates against a target molecule. The advantage of high-throughput kinetic measurements over equilibrium assessments is the ability to measure each of the kinetic components of binding affinity. Although high-throughput capabilities have improved with advances in instrument hardware, three bottlenecks in data processing remain: (1) intrinsic molecular properties that lead to poor biophysical quality in vitro are not accounted for in commercially available analysis models, (2) processing data through a user interface is time-consuming and not amenable to parallelized data collection, and (3) a commercial solution that includes historical kinetic data in the analysis of kinetic competition data does not exist...
April 1, 2017: SLAS Technology
https://www.readbyqxmd.com/read/28430266/machine-learning-approach-to-oam-beam-demultiplexing-via-convolutional-neural-networks
#5
Timothy Doster, Abbie T Watnik
Orbital angular momentum (OAM) beams allow for increased channel capacity in free-space optical communication. Conventionally, these OAM beams are multiplexed together at a transmitter and then propagated through the atmosphere to a receiver where, due to their orthogonality properties, they are demultiplexed. We propose a technique to demultiplex these OAM-carrying beams by capturing an image of the unique multiplexing intensity pattern and training a convolutional neural network (CNN) as a classifier. This CNN-based demultiplexing method allows for simplicity of operation as alignment is unnecessary, orthogonality constraints are loosened, and costly optical hardware is not required...
April 20, 2017: Applied Optics
https://www.readbyqxmd.com/read/28430109/acquisition-of-electrocardiogram-signals-during-magnetic-resonance-imaging
#6
Julien Oster, Gari Clifford
The recording of the electrocardiogram (ECG) during Magnetic Resonance Imaging (MRI) acquisition is of great interest and importance. Firstly, MRI acquisition is a relatively slow process, which therefore complicates the imaging of moving organs. Cardiac MRI requires the development of strategies for acquiring high quality images, which is mainly achieved by synchronising the image acquisition with a specific time during the cardiac cycle. The ECG is used to monitor the heart's activity, and the detection of the largest and steepest peak in the cardiac cycle (the QRS complex) triggers the acquisition of slices of the k-space...
April 21, 2017: Physiological Measurement
https://www.readbyqxmd.com/read/28428919/tibial-bone-grafting-for-wrist-reconstruction
#7
Schneider K Rancy, Stephanie D Malliaris, Scott W Wolfe
Background Iliac crest bone graft harvesting is routinely performed for upper extremity orthopedic procedures despite high complication rates associated with sensory nerve injury, hematoma, chronic pain, and fracture. Description of Technique Cancellous bone graft is harvested from the proximal tibia using a medial approach, minimizing donor site morbidity. Patients and Methods A retrospective review was undertaken of 14 patients who underwent cancellous proximal tibia bone graft harvesting to augment healing of wrist reconstruction, with 2 months minimum follow-up...
May 2017: Journal of Wrist Surgery
https://www.readbyqxmd.com/read/28428916/extensor-carpi-ulnaris-instability-following-ulnar-shortening-osteotomy
#8
Mohamed Noureldin, Sanjeev Kakar
Background Ulnar shortening osteotomy (USO) is a well-established procedure for the treatment of ulnar impaction syndrome. Although uncommon, the procedure can be associated with complications including nonunion, malunion, and hardware irritation. Case Description We present a 56-year-old woman who developed extensor carpi ulnaris (ECU) tendon instability following an USO. Literature Review The etiology of such a complication can be multifactorial. Clinical Relevance The recurrence of ulnar pain following an USO should raise the suspicion of possible ECU instability within the differential diagnosis...
May 2017: Journal of Wrist Surgery
https://www.readbyqxmd.com/read/28428213/clinically-feasible-microstructural-mri-to-quantify-cervical-spinal-cord-tissue-injury-using-dti-mt-and-t2-weighted-imaging-assessment-of-normative-data-and-reliability
#9
A R Martin, B De Leener, J Cohen-Adad, D W Cadotte, S Kalsi-Ryan, S F Lange, L Tetreault, A Nouri, A Crawley, D J Mikulis, H Ginsberg, M G Fehlings
BACKGROUND AND PURPOSE: DTI, magnetization transfer, T2*-weighted imaging, and cross-sectional area can quantify aspects of spinal cord microstructure. However, clinical adoption remains elusive due to complex acquisitions, cumbersome analysis, limited reliability, and wide ranges of normal values. We propose a simple multiparametric protocol with automated analysis and report normative data, analysis of confounding variables, and reliability. MATERIALS AND METHODS: Forty healthy subjects underwent T2WI, DTI, magnetization transfer, and T2*WI at 3T in <35 minutes using standard hardware and pulse sequences...
April 20, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/28428047/diffusion-mri-of-the-human-brain-at-ultra-high-field-uhf-a-review
#10
Daniel Gallichan
The continued drive towards MRI scanners operating at increasingly higher main magnetic fields is primarily motivated by the maxim that more teslas mean more signal and lead to better images. This promise of increased signal, which cannot easily be achieved in other ways, encourages efforts to overcome the inextricable technical challenges which accompany this endeavor. Unlike for many applications, however, diffusion imaging is not currently able to directly reap these potential signal gains - at the time of writing it seems fair to say that, for matched gradient and RF hardware, the majority of diffusion images acquired at 7T, while comparable in quality to those achievable at 3T, do not demonstrate a clear advantage over what can be obtained at lower field...
April 17, 2017: NeuroImage
https://www.readbyqxmd.com/read/28425043/innovative-development-path-of-ethnomedicines-a-case-study
#11
Zhaoyun Zhu, Yali Gui, Li Wang, Ting Wang, Yang Yang, Yunzhuang Niu, Dehuan Fu, Jingkun Wang, Tao Cui
Innovative development extends the vitality of ethnomedicines. Developing ethnomedicines is not only beneficial to the public but also to the related industry and transforms economic growth, driving local social and economic development further. Its economic benefit can be used to optimize and promote the hardware and software of the platform, as well as support the sustainable development of ethnomedicines. Apart from research and discussion on the innovative development of ethnomedicines on the basis of theory and regulations, this series of articles also summarizes cases that are conducive to the overall understanding of the necessity and feasibility of the innovative development...
April 19, 2017: Frontiers of Medicine
https://www.readbyqxmd.com/read/28423945/on-line-soft-sensing-in-upstream-bioprocessing
#12
Judit Randek, Carl-Fredrik Mandenius
This review provides an overview and a critical discussion of novel possibilities of applying soft sensors for on-line monitoring and control of industrial bioprocesses. Focus is on bio-product formation in the upstream process but also the integration with other parts of the process is addressed. The term soft sensor is used for the combination of analytical hardware data (from sensors, analytical devices, instruments and actuators) with mathematical models that create new real-time information about the process...
April 20, 2017: Critical Reviews in Biotechnology
https://www.readbyqxmd.com/read/28421179/synergy-based-bilateral-port-a-universal-control-module-for-tele-manipulation-frameworks-using-asymmetric-master-slave-systems
#13
Anais Brygo, Ioannis Sarakoglou, Giorgio Grioli, Nikos Tsagarakis
Endowing tele-manipulation frameworks with the capability to accommodate a variety of robotic hands is key to achieving high performances through permitting to flexibly interchange the end-effector according to the task considered. This requires the development of control policies that not only cope with asymmetric master-slave systems but also whose high-level components are designed in a unified space in abstraction from the devices specifics. To address this dual challenge, a novel synergy port is developed that resolves the kinematic, sensing, and actuation asymmetries of the considered system through generating motion and force feedback references in the hardware-independent hand postural synergy space...
2017: Frontiers in Bioengineering and Biotechnology
https://www.readbyqxmd.com/read/28420977/development-and-training-of-a-neural-controller-for-hind-leg-walking-in-a-dog-robot
#14
Alexander Hunt, Nicholas Szczecinski, Roger Quinn
Animals dynamically adapt to varying terrain and small perturbations with remarkable ease. These adaptations arise from complex interactions between the environment and biomechanical and neural components of the animal's body and nervous system. Research into mammalian locomotion has resulted in several neural and neuro-mechanical models, some of which have been tested in simulation, but few "synthetic nervous systems" have been implemented in physical hardware models of animal systems. One reason is that the implementation into a physical system is not straightforward...
2017: Frontiers in Neurorobotics
https://www.readbyqxmd.com/read/28420197/a-novel-auto-sorting-system-for-chinese-cabbage-seeds
#15
Kuo-Yi Huang, Jian-Feng Cheng
This paper presents a novel machine vision-based auto-sorting system for Chinese cabbage seeds. The system comprises an inlet-outlet mechanism, machine vision hardware and software, and control system for sorting seed quality. The proposed method can estimate the shape, color, and textural features of seeds that are provided as input neurons of neural networks in order to classify seeds as "good" and "not good" (NG). The results show the accuracies of classification to be 91.53% and 88.95% for good and NG seeds, respectively...
April 18, 2017: Sensors
https://www.readbyqxmd.com/read/28420086/blockwise-ppg-enhancement-based-on-time-variant-zero-phase-harmonic-notch-filtering
#16
Chanki Park, Hyunsoon Shin, Boreom Lee
So far, many approaches have been developed for motion artifact (MA) reduction from photoplethysmogram (PPG). Specifically, single-input MA reduction methods are useful to apply wearable and mobile healthcare systems because of their low hardware costs and simplicity. However, most of them are insufficiently developed to be used in real-world situations, and they suffer from a phase distortion problem. In this study, we propose a novel single-input MA reduction algorithm based on time-variant forward-backward harmonic notch filtering...
April 14, 2017: Sensors
https://www.readbyqxmd.com/read/28419484/variations-in-the-functional-visual-field-for-detection-of-lung-nodules-on-chest-computed-tomography-impact-of-nodule-size-distance-and-local-lung-complexity
#17
Lukas Ebner, Martin Tall, Kingshuk Roy Choudhury, Donald L Ly, Justus E Roos, Sandy Napel, Geoffrey D Rubin
PURPOSE: To explore the characteristics that impact lung nodule detection by peripheral vision when searching for lung nodules on chest CT-scans. METHODS: This study was approved by the local IRB and HIPAA compliant. A simulated primary (1°) target mass (2 x 2 x 5 cm) was embedded into 5-cm thick sub-volumes (SV) extracted from three unenhanced lung MDCT-scans (64-row, 1.25 mm thickness, 0.7 mm increment). One of 30 solid, secondary nodules with either 3-4 mm and 5-8 mm diameters were embedded into 192 of 207 SVs...
April 17, 2017: Medical Physics
https://www.readbyqxmd.com/read/28418257/investigating-acquisition-performance-on-the-orbitrap-fusion-when-using-tandem-ms-ms-ms-scanning-with-isobaric-tags
#18
Christopher S Hughes, Victor Spicer, Oleg V Krokhin, Gregg B Morin
Methods for isobaric-tagged peptide analysis (e.g., TMT, iTRAQ), such as the synchronous precursor selection (SPS) tandem MS/MS/MS (MS(3)) approach, enable maintenance of reporter ion accuracy and precision by reducing the ratio compression caused by coisolated precursor ions. However, the decreased throughput of the MS(3) approach necessitates careful optimization of acquisition strategies and methods to ensure maximal proteome coverage. We present a systematic analysis of acquisition parameters used to analyze isobaric-tagged peptide samples on current generation Orbitrap mass spectrometer (MS) hardware...
April 20, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/28418254/evaluating-the-characteristics-of-reporter-ion-signal-acquired-in-the-orbitrap-analyzer-for-isobaric-mass-tag-proteome-quantification-experiments
#19
Christopher S Hughes, Chenchen Zhu, Victor Spicer, Oleg V Krokhin, Gregg B Morin
Multiplexed quantification with isobaric chemical tags (e.g., TMT, iTRAQ) provides a robust and efficient means to comparatively examine proteome dynamics between several biological states using a mass spectrometer (MS). The quantitative nature of isobaric tags necessitates strict validation of the observed ion signals in the chosen MS detector before differential patterns are extracted between biological states. We present an in-depth analysis of isobaric tag data acquired on current generation Orbitrap MS hardware to illustrate pitfalls in acquisition settings that can negatively impact results...
April 20, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/28416851/-one-of-the-pitfalls-in-the-surgical-treatment-of-maisonneuve-fractures-a-case-report
#20
H Q Ji, F Zhou, Y Tian, Z S Zhang, Y Guo, Y Lv, Z W Yang, G J Hou
There exist controversies in the surgical treatment of maisonneuve injury with regard to reduction and fixation of syndesmosis and management of proximal fibular fracture. It is very important for the orthopaedic surgeons to learn more techniques and avoid pitfalls from clinical practice. We summarized the clinical data of 1 failed case, a 20-year-old girl with big body weight who underwent a primary surgery for the treatment of maisonneuve fracture with minimally invasive reduction and fixation of ankle syndesmosis and posterior malleolus and open reduction and internal fixation of medial malleolus, then a revision surgery for the treatment of iatrogenic syndesmotic malreduction with open reduction and re-stabilization of ankle syndesmosis supplemented with open reduction and internal fixation of proximal fibular facture...
April 18, 2017: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
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