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https://www.readbyqxmd.com/read/29454295/synthetic-and-genetically-encoded-fluorescent-neural-activity-indicators
#1
REVIEW
Claire Deo, Luke D Lavis
The ultimate goal of neuroscience is to relate the complex activity of cells and cell-networks to behavior and cognition. This requires tools and techniques to visualize neuronal activity. Fluorescence microscopy is an ideal tool to measure activity of cells in the brain due to the high sensitivity of the technique and the growing portfolio of optical hardware and fluorescent sensors. Here, we give a chemist's perspective on the recent progress of fluorescent activity indicators that enable the measurement of cellular events in the living brain...
February 14, 2018: Current Opinion in Neurobiology
https://www.readbyqxmd.com/read/29454121/complications-of-impulse-generator-exchange-surgery-for-deep-brain-stimulation-a-single-centre-retrospective-study
#2
Ann-Kristin Helmers, Isabel Lübbing, Falk Birkenfeld, Karsten Witt, Michael Synowitz, Hubertus Maximilian Mehdorn, Daniela Falk
OBJECTIVE: Non-rechargeable deep brain stimulation (DBS) impulse generators (IG) with a low or empty battery status require surgical IG exchange several years after initial implantation. Complication rates in patients undergoing DBS surgery range from 7.6% to 25.3%. The aim of this study was to investigate the complication rates after IG exchange surgery and to identify risk factors for complications. METHODS: We retrospectively analysed complications following IG exchange surgery from 2008 to 2015 in a single-centre university hospital setting...
February 14, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29451499/characterising-the-frequency-response-of-impedance-changes-during-evoked-physiological-activity-in-the-rat-brain
#3
Mayo Faulkner, Sana Hannan, Kirill Y Aristovich, James Avery, David S Holder
<i>Objective</i>. Electrical Impedance Tomography (EIT) can image impedance changes associated with evoked physiological activity in the cerebral cortex using an array of epicortical electrodes. An impedance change is observed as the externally applied current, normally confined to the extracellular space is admitted into the conducting intracellular space during neuronal depolarisation. The response is largest at DC and decreases at higher frequencies due to capacitative transfer of current across the membrane...
February 16, 2018: Physiological Measurement
https://www.readbyqxmd.com/read/29449761/active-localization-and-tracking-of-needle-and-target-in-robotic-image-guided-intervention-systems
#4
Mark Renfrew, Mark Griswold, M Cenk Çavuşoğlu
This paper describes a framework of algorithms for the active localization and tracking of flexible needles and targets during image-guided percutaneous interventions. The needle and target configurations are tracked by Bayesian filters employing models of the needle and target motions and measurements of the current system state obtained from an intra-operative imaging system which is controlled by an entropy-minimizing active localization algorithm. Versions of the system were built using particle and unscented Kalman filters and their performance was measured using both simulations and hardware experiments with real magnetic resonance imaging data of needle insertions into gel phantoms...
January 2018: Autonomous Robots
https://www.readbyqxmd.com/read/29446113/use-of-a-simple-inexpensive-dual-modality-phantom-as-a-learning-tool-for-magnetic-resonance-imaging-ultrasound-fusion-techniques
#5
William R Walter, Christopher J Burke, Mamadou Diallo, Ronald S Adler
We describe an easily constructed, customizable phantom for magnetic resonance imaging-ultrasound fusion imaging and demonstrate its role as a learning tool to initiate clinical use of this emerging modality. Magnetic resonance imaging-ultrasound fusion can prove unwieldy to integrate into routine practice. We demonstrate real-time fusion with single-sequence magnetic resonance imaging uploaded to the ultrasound console. Phantom training sessions allow radiologists and sonographers to practice fiducial marker selection and improve efficiency with the fusion hardware and software interfaces...
February 15, 2018: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/29443962/a-programmable-two-qubit-quantum-processor-in-silicon
#6
T F Watson, S G J Philips, E Kawakami, D R Ward, P Scarlino, M Veldhorst, D E Savage, M G Lagally, Mark Friesen, S N Coppersmith, M A Eriksson, L M K Vandersypen
Now that it is possible to achieve measurement and control fidelities for individual quantum bits (qubits) above the threshold for fault tolerance, attention is moving towards the difficult task of scaling up the number of physical qubits to the large numbers that are needed for fault-tolerant quantum computing. In this context, quantum-dot-based spin qubits could have substantial advantages over other types of qubit owing to their potential for all-electrical operation and ability to be integrated at high density onto an industrial platform...
February 14, 2018: Nature
https://www.readbyqxmd.com/read/29443893/a-modular-iot-platform-for-real-time-indoor-air-quality-monitoring
#7
Mohieddine Benammar, Abderrazak Abdaoui, Sabbir H M Ahmad, Farid Touati, Abdullah Kadri
The impact of air quality on health and on life comfort is well established. In many societies, vulnerable elderly and young populations spend most of their time indoors. Therefore, indoor air quality monitoring (IAQM) is of great importance to human health. Engineers and researchers are increasingly focusing their efforts on the design of real-time IAQM systems using wireless sensor networks. This paper presents an end-to-end IAQM system enabling measurement of CO₂, CO, SO₂, NO₂, O₃, Cl₂, ambient temperature, and relative humidity...
February 14, 2018: Sensors
https://www.readbyqxmd.com/read/29443818/resection-of-a-giant-cell-tumor-of-the-proximal-aspect-of-the-radius-with-osteoarticular-allograft-reconstruction-a-case-report
#8
Suresh K Nayar, Eric J Dein, Andrea M Spiker, Johnathan A Bernard, Bashir A Zikria, Kristy L Weber
CASE: Giant-cell tumors are locally aggressive osteolytic benign tumors that are characterized by multinucleated giant cells. Recurrence rates are ≤30% after curettage and <5% after resection, but reconstruction can be difficult. We describe an osteoarticular allograft reconstruction of the proximal aspect of the radius in a 23-year-old man after resection of a giant-cell tumor. CONCLUSION: Five months after surgery, the patient had satisfactory joint articulation, range of motion, and strength, with no signs of hardware or graft failure...
February 14, 2018: JBJS Case Connector
https://www.readbyqxmd.com/read/29443021/measurement-analysis-of-the-temporal-discrimination-threshold-applied-to-cervical-dystonia
#9
Rebecca B Beck, Eavan M McGovern, John S Butler, Dorina Birsanu, Brendan Quinlivan, Ines Beiser, Shruti Narasimham, Sean O'Riordan, Michael Hutchinson, Richard B Reilly
The temporal discrimination threshold (TDT) is the shortest time interval at which an observer can discriminate two sequential stimuli as being asynchronous (typically 30-50 ms). It has been shown to be abnormal (prolonged) in neurological disorders, including cervical dystonia, a phenotype of adult onset idiopathic isolated focal dystonia. The TDT is a quantitative measure of the ability to perceive rapid changes in the environment and is considered indicative of the behavior of the visual neurons in the superior colliculus, a key node in covert attentional orienting...
January 27, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29440763/rhythm-an-open-source-imaging-toolkit-for-cardiac-panoramic-optical-mapping
#10
Christopher Gloschat, Kedar Aras, Shubham Gupta, N Rokhaya Faye, Hanyu Zhang, Roman A Syunyaev, Roman A Pryamonosov, Jack Rogers, Matthew W Kay, Igor R Efimov
Fluorescence optical imaging techniques have revolutionized the field of cardiac electrophysiology and advanced our understanding of complex electrical activities such as arrhythmias. However, traditional monocular optical mapping systems, despite having high spatial resolution, are restricted to a two-dimensional (2D) field of view. Consequently, tracking complex three-dimensional (3D) electrical waves such as during ventricular fibrillation is challenging as the waves rapidly move in and out of the field of view...
February 13, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29439424/a-cots-based-portable-system-to-conduct-accurate-substance-concentration-measurements
#11
Juan Aznar-Poveda, Jose Antonio Lopez-Pastor, Antonio-Javier Garcia-Sanchez, Joan Garcia-Haro, Toribio Fernández Otero
Traditionally, electrochemical procedures aimed at determining substance concentrations have required a costly and cumbersome laboratory environment. Specialized equipment and personnel obtain precise results under complex and time-consuming settings. Innovative electrochemical-based sensors are emerging to alleviate this difficulty. However, they are generally scarce, proprietary hardware and/or software, and focused only on measuring a restricted range of substances. In this paper, we propose a portable, flexible, low-cost system, built from commercial off-the-shelf components and easily controlled, using open-source software...
February 10, 2018: Sensors
https://www.readbyqxmd.com/read/29438263/validity-and-acceptance-of-color-vision-testing-on-smartphones
#12
Omar K Ozgur, Trisha S Emborgo, Mark B Vieyra, Rebecca F Huselid, Rudrani Banik
BACKGROUND: Ishihara color plates (ICP) are the most commonly used color vision test (CVT) worldwide. With the advent of new technologies, attempts have been made to streamline the process of CVT. As hardware and software evolve, smartphone-based testing modalities may aid ophthalmologists in performing more efficient ophthalmic examinations. We assess the validity of smartphone color vision testing (CVT) by comparing results using the Eye Handbook (EHB) CVT application with standard Ishihara color plates (ICP)...
March 2018: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
https://www.readbyqxmd.com/read/29438206/surgical-outcome-after-less-rigid-fixation-in-open-cranial-vault-remodeling-for-craniosynostosis
#13
Khai Luen Koh, Ali Zain
: Open cranial vault remodeling techniques require rigid fixation with hardware such as plates and screws; however, complications can occur. The purpose of this study was to assess the surgical outcome after open reconstruction for craniosynostosis with less rigid fixation using nonabsorbable suture. METHODS: Retrospective review of patients who underwent open craniofacial reconstruction for craniosynostosis at the Hospital Kuala Lumpur between January 2011 and December 2016 were performed...
February 12, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29437061/mid-term-follow-up-of-patients-with-hindfoot-arthrodesis-with-retrograde-compression-intramedullary-nail-in-charcot-neuroarthropathy-of-the-hindfoot
#14
M Chraim, S Krenn, H M Alrabai, H-J Trnka, P Bock
AIMS: Hindfoot arthrodesis with retrograde intramedullary nailing has been described as a surgical strategy to reconstruct deformities of the ankle and hindfoot in patients with Charcot arthropathy. This study presents case series of Charcot arthropathy patients treated with two different retrograde intramedullary straight compression nails in order to reconstruct the hindfoot and assess the results over a mid-term follow-up. PATIENTS AND METHODS: We performed a retrospective analysis of 18 consecutive patients and 19 operated feet with Charcot arthropathy who underwent a hindfoot arthrodesis using a retrograde intramedullary compression nail...
February 2018: Bone & Joint Journal
https://www.readbyqxmd.com/read/29436552/real-time-multiplexed-pcr-using-surface-enhanced-raman-spectroscopy-in-a-thermoplastic-chip
#15
S M Restaino, I M White
Surface enhanced Raman spectroscopy (SERS) has the potential to enable point-of-care sensing across the spectrum of chemical and biological analytes. In diagnostic assays, SERS has been demonstrated to increase the multiplexing density while reducing the burden of fluorescence hardware. One particular application of interest is the use of SERS to provide a multiplexed optical read-out following polymerase chain reaction (PCR). To date, however, the reported PCR-SERS assays require endpoint mixing with a plasmonic nanoparticle solution for detection, thus adding manual steps and preventing real-time, quantitative PCR...
February 13, 2018: Lab on a Chip
https://www.readbyqxmd.com/read/29435655/intra-abdominal-and-intra-pelvic-complications-following-operations-around-the-hip-causes-and-management-a-review-of-the-literature
#16
REVIEW
Panagiotis P Anastasopoulos, Panagiotis Lepetsos, Andreas O Leonidou, Anastasios Gketsos, Eleftherios Tsiridis, George A Macheras
Although successful and well-established procedures, hip operations whether elective or trauma are coupled with a variety of complications. Among the most uncommon complications are injuries to intra-abdominal or intra-pelvic organs which could prove potentially life-threatening. While there are various reports of such injuries in the literature, we aimed to perform a systematic review in order to examine the causes and relationships between intra-abdominal and intra-pelvic complications and the mechanism of injury, the pattern of presentation, identification, the course of management and outcomes...
February 12, 2018: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://www.readbyqxmd.com/read/29431017/touchless-computer-interfaces-in-hospitals-a-review
#17
Seán Cronin, Gavin Doherty
The widespread use of technology in hospitals and the difficulty of sterilising computer controls has increased opportunities for the spread of pathogens. This leads to an interest in touchless user interfaces for computer systems. We present a review of touchless interaction with computer equipment in the hospital environment, based on a systematic search of the literature. Sterility provides an implied theme and motivation for the field as a whole, but other advantages, such as hands-busy settings, are also proposed...
February 1, 2018: Health Informatics Journal
https://www.readbyqxmd.com/read/29430491/total-knee-arthroplasty-in-patients-with-retention-of-prior-hardware-material-what-is-the-outcome
#18
Jorge Manrique, Mohammad R Rasouli, Camilo Restrepo, Mitchell G Maltenfort, Jonathan Beri, Jeffrey Oliver, Raj Patel, Javad Parvizi
Background: There is an information gap in literature regarding postoperative outcome of total knee arthroplasty (TKA) in patients with hardware in-situ from the previous knee surgery. The present study aims to evaluate impact of retained hardware on short-term outcome of TKA patients. Methods: Perioperative radiographs of patients who had undergone TKA between 2007 and 2012 were reviewed and patients in whom partial or complete retention of hardware was evident after TKA were included...
January 2018: Archives of Bone and Joint Surgery
https://www.readbyqxmd.com/read/29429610/automated-ultrafast-kilovoltage-megavoltage-cone-beam-ct-for-image-guided-radiotherapy-of-lung-cancer-system-description-and-real-time-results
#19
Manuel Blessing, Anna Arns, Hansjoerg Wertz, Dzmitry Stsepankou, Judit Boda-Heggemann, Juergen Hesser, Frederik Wenz, Frank Lohr
PURPOSE: To establish a fully automated kV-MV CBCT imaging method on a clinical linear accelerator that allows image acquisition of thoracic targets for patient positioning within one breath-hold (∼15s) under realistic clinical conditions. METHODS AND MATERIALS: Our previously developed FPGA-based hardware unit which allows synchronized kV-MV CBCT projection acquisition is connected to a clinical linear accelerator system via a multi-pin switch; i.e. either kV-MV imaging or conventional clinical mode can be selected...
February 8, 2018: Zeitschrift Für Medizinische Physik
https://www.readbyqxmd.com/read/29428162/trends-in-active-and-assisted-living-open-hardware-architecture-human-data-interpretation-intervention-and-assistance
#20
EDITORIAL
Marcin Grzegorzek, Arkadiusz Gertych, Georg Aumayr, Ewa Piętka
No abstract text is available yet for this article.
February 2, 2018: Computers in Biology and Medicine
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