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myocardial steatosis

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https://www.readbyqxmd.com/read/28606026/subclinical-myocardial-disease-by-cardiac-magnetic-resonance-imaging-and-spectroscopy-in-healthy-hiv-hepatitis-c-virus-coinfected-persons
#1
Kara W Chew, Chia-Ying Liu, Bharath Ambale-Venkatesh, Diana Liao, Tamara B Horwich, João A C Lima, David A Bluemke, J Paul Finn, Adeel A Butt, Judith S Currier
Objective The contribution of hepatitis C virus (HCV) infection to the risk of heart failure in human immunodeficiency virus (HIV)-coinfected persons is unknown. The objective was to characterize cardiac function and morphology in HIV-treated coinfected persons. Methods In a cross-sectional study, HIV-infected patients virologically suppressed on antiretroviral therapy without known cardiovascular disease or diabetes mellitus underwent cardiac magnetic resonance imaging and spectroscopy for measures of cardiac function, myocardial fibrosis, and steatosis...
January 1, 2017: Journal of International Medical Research
https://www.readbyqxmd.com/read/28578226/cocaine-use-may-modify-hiv-art-associated-myocardial-steatosis-and-hepatic-steatosis
#2
Shenghan Lai, Gary Gerstenblith, Richard D Moore, David D Celentano, David A Bluemke, Glenn Treisman, Chia-Ying Liu, Ji Li, Shaoguang Chen, Thomas Kickler, Hong Lai
BACKGROUND: It has been recognized that myocardial and hepatic steatosis may be more prevalent in HIV-infected individuals on antiretroviral therapy (ART); however, factors associated with these conditions have not been thoroughly investigated. The goals of this study were (1) to identify the risk factors for myocardial and hepatic steatosis in HIV-infected African Americans (AAs) and explore whether ART use is independently associated with myocardial and hepatic steatosis, and (2) to examine whether and how cocaine use influences any associations of ART use with myocardial and hepatic steatosis...
May 26, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28449094/hepatic-tm6sf2-overexpression-affects-cellular-apob-trafficking-plasma-lipid-levels-hepatic-steatosis-and-atherosclerosis
#3
Nicole Ehrhardt, Michael E Doche, Shuang Chen, Hui Z Mao, Meghan T Walsh, Candy Bedoya, Maha Guindi, Weidong Xiong, Joseph Ignatius Irudayam, Jahangir Iqbal, Sebastien Fuchs, Samuel W French, M Mahmood Hussain, Moshe Arditi, Vaithilingaraja Arumugaswami, Miklós Péterfy
The human TM6SF2 gene has been implicated in plasma lipoprotein metabolism, alcoholic and non-alcoholic fatty liver disease and myocardial infarction in multiple genome-wide association studies. To investigate the role of Tm6sf2 in metabolic homeostasis, we generated mice with elevated expression using adeno-associated virus (AAV)-mediated gene delivery. Hepatic overexpression of mouse Tm6sf2 resulted in phenotypes previously observed in Tm6sf2-deficient mice including reduced plasma lipid levels, diminished hepatic TG secretion and increased hepatosteatosis...
April 25, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/28439258/diabetic-cardiomyopathy-an-immunometabolic-perspective
#4
REVIEW
Paras K Mishra, Wei Ying, Shyam Sundar Nandi, Gautam K Bandyopadhyay, Kaushik K Patel, Sushil K Mahata
The heart possesses a remarkable inherent capability to adapt itself to a wide array of genetic and extrinsic factors to maintain contractile function. Failure to sustain its compensatory responses results in cardiac dysfunction, leading to cardiomyopathy. Diabetic cardiomyopathy (DCM) is characterized by left ventricular hypertrophy and reduced diastolic function, with or without concurrent systolic dysfunction in the absence of hypertension and coronary artery disease. Changes in substrate metabolism, oxidative stress, endoplasmic reticulum stress, formation of extracellular matrix proteins, and advanced glycation end products constitute the early stage in DCM...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/28414112/binding-of-erucic-acid-with-human-serum-albumin-using-a-spectroscopic-and-molecular-docking-study
#5
Gulam Rabbani, Mohammad Hassan Baig, Arif Tasleem Jan, Eun Ju Lee, Mohsin Vahid Khan, Masihuz Zaman, Abd-ElAziem Farouk Gad, Rizwan Hasan Khan, Inho Choi
Erucic acid (EA) is one of the key fatty acids usually found in canola oil, mustard oil and rapeseed oil. Consumption of EA in primates was found to cause myocardial lipidosis and cardiac steatosis. To have an insight of the effect of EA in humans, we performed in vitro interaction studies of EA with the primary plasma protein, human serum albumin (HSA). Spectroscopic (UV-vis and fluorescence) analysis of the EA-HSA interaction revealed a static mode of quenching, with binding constant Kb ∼10(4) reflecting high affinity of EA for HSA...
April 13, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28315199/hiv-infection-and-risk-of-cardiovascular-diseases-beyond-coronary-artery-disease
#6
REVIEW
Revery P Barnes, John Charles A Lacson, Hossein Bahrami
PURPOSE OF REVIEW: Cardiovascular disease (CVD) increasingly afflicts people living with HIV (PLWH) in the contemporary era of antiretroviral therapy (ART). Coronary artery disease (CAD) is the most widely studied cardiovascular problem in PLWH; however, less is known about other clinically relevant subtypes of CVD such as heart failure (HF), cerebrovascular disease, sudden cardiac death, pericardial diseases, and pulmonary hypertension. This paper reviews evidence of other subtypes of CVD as emerging issues in the post-ART era...
May 2017: Current Atherosclerosis Reports
https://www.readbyqxmd.com/read/28246388/serum-microrna-1-and-microrna-133a-levels-reflect-myocardial-steatosis-in-uncomplicated-type-2-diabetes
#7
D de Gonzalo-Calvo, R W van der Meer, L J Rijzewijk, J W A Smit, E Revuelta-Lopez, L Nasarre, J C Escola-Gil, H J Lamb, V Llorente-Cortes
Using in vitro, in vivo and patient-based approaches, we investigated the potential of circulating microRNAs (miRNAs) as surrogate biomarkers of myocardial steatosis, a hallmark of diabetic cardiomyopathy. We analysed the cardiomyocyte-enriched miRNA signature in serum from patients with well-controlled type 2 diabetes and with verified absence of structural heart disease or inducible ischemia, and control volunteers of the same age range and BMI (N = 86), in serum from a high-fat diet-fed murine model, and in exosomes from lipid-loaded HL-1 cardiomyocytes...
December 2017: Scientific Reports
https://www.readbyqxmd.com/read/27956794/galectin-3-and-il-33-st2-axis-roles-and-interplay-in-diet-induced-steatohepatitis
#8
REVIEW
Nada Pejnovic, Ilija Jeftic, Nemanja Jovicic, Nebojsa Arsenijevic, Miodrag L Lukic
Immune reactivity and chronic low-grade inflammation (metaflammation) play an important role in the pathogenesis of obesity-associated metabolic disorders, including type 2 diabetes and nonalcoholic fatty liver disease (NAFLD), a spectrum of diseases that include liver steatosis, nonalcoholic steatohepatitis (NASH), fibrosis, and cirrhosis. Increased adiposity and insulin resistance contribute to the progression from hepatic steatosis to NASH and fibrosis through the development of proinflammatory and profibrotic processes in the liver, including increased hepatic infiltration of innate and adaptive immune cells, altered balance of cytokines and chemokines, increased reactive oxygen species generation and hepatocellular death...
November 28, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27774066/rhizoma-coptidis-a-potential-cardiovascular-protective-agent
#9
Hui-Li Tan, Kok-Gan Chan, Priyia Pusparajah, Acharaporn Duangjai, Surasak Saokaew, Tahir Mehmood Khan, Learn-Han Lee, Bey-Hing Goh
Cardiovascular diseases (CVDs) are among the leading causes of morbidity and mortality in both the developed and developing world. Rhizoma coptidis (RC), known as Huang Lian in China, is the dried rhizome of medicinal plants from the family Ranunculaceae, such as Coptis chinensis Franch, C. deltoidea C.Y. Cheng et Hsiao, and C. teeta Wall which has been used by Chinese medicinal physicians for more than 2000 years. In China, RC is a common component in traditional medicines used to treat CVD associated problems including obesity, diabetes mellitus, hyperlipidemia, hyperglycemia and disorders of lipid metabolism...
2016: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/27595755/metabolic-and-cardiovascular-complications-in-hiv-hcv-co-infected-patients
#10
Roger Bedimo, Oladapo Abodunde
PURPOSE OF REVIEW: Fifteen to thirty percent of HIV-infected persons in North America and Europe are co-infected with chronic hepatitis C (HCV). The latter is associated with a significant number of extra-hepatic metabolic complications that could compound HIV-associated increased cardiovascular risk. This article reviews the basic science and epidemiologic and clinical evidence for increased cardio-metabolic risk among HIV/HCV-co-infected patients and discusses potential underlying mechanisms...
September 5, 2016: Current HIV/AIDS Reports
https://www.readbyqxmd.com/read/27404689/echocardiography-and-nafld-non-alcoholic-fatty-liver-disease
#11
Francesca M Trovato, Giuseppe F Martines, Daniela Catalano, Giuseppe Musumeci, Clara Pirri, Guglielmo M Trovato
UNLABELLED: Non-alcoholic-fatty-liver-disease (NAFLD) is associated with atherosclerosis, increased cardiovascular risks and mortality. We investigated if, independently of insulin resistance, diet, physical activity and obesity, fatty liver involvement has any relationship with echocardiographic measurements in NAFLD. PATIENTS AND METHODS: 660 NAFLD and 791 non-NAFLD subjects, referred to the same out-patients medical unit for lifestyle-nutritional prescription, were studied...
October 15, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27364051/ectopic-and-visceral-fat-deposition-in%C3%A2-lean-and-obese-patients-with-type%C3%A2-2%C3%A2-diabetes
#12
Eylem Levelt, Michael Pavlides, Rajarshi Banerjee, Masliza Mahmod, Catherine Kelly, Joanna Sellwood, Rina Ariga, Sheena Thomas, Jane Francis, Christopher Rodgers, William Clarke, Nikant Sabharwal, Charalambos Antoniades, Jurgen Schneider, Matthew Robson, Kieran Clarke, Theodoros Karamitsos, Oliver Rider, Stefan Neubauer
BACKGROUND: Type 2 diabetes (T2D) and obesity are associated with nonalcoholic fatty liver disease, cardiomyopathy, and cardiovascular mortality. Both show stronger links between ectopic and visceral fat deposition, and an increased cardiometabolic risk compared with subcutaneous fat. OBJECTIVES: This study investigated whether lean patients (Ln) with T2D exhibit increased ectopic and visceral fat deposition and whether these are linked to cardiac and hepatic changes...
July 5, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27333924/effects-of-activation-of-endocannabinoid-system-on-myocardial-metabolism
#13
Agnieszka Polak, Ewa Harasim, Adrian Chabowski
Endocannabinoids exert their effect on the regulation of energy homeostasis via activation of specific receptors. They control food intake, secretion of insulin, lipids and glucose metabolism, lipid storage. Long chain fatty acids are the main myocardial energy substrate. However, the heart exerts enormous metabolic flexibility emphasized by its ability to utilzation not only fatty acids, but also glucose, lactate and ketone bodies. Endocannabinoids can directly act on the cardiomyocytes through the CB1 and CB2 receptors present in cardiomyocytes...
May 21, 2016: Postȩpy Higieny i Medycyny Doświadczalnej
https://www.readbyqxmd.com/read/27120622/a-heterozygous-zmpste24-mutation-associated-with-severe-metabolic-syndrome-ectopic-fat-accumulation-and-dilated-cardiomyopathy
#14
Damien Galant, Bénédicte Gaborit, Camille Desgrouas, Ines Abdesselam, Monique Bernard, Nicolas Levy, Françoise Merono, Catherine Coirault, Patrice Roll, Arnaud Lagarde, Nathalie Bonello-Palot, Patrice Bourgeois, Anne Dutour, Catherine Badens
ZMPSTE24 encodes the only metalloprotease, which transforms prelamin into mature lamin A. Up to now, mutations in ZMPSTE24 have been linked to Restrictive Dermopathy (RD), Progeria or Mandibulo-Acral Dysplasia (MAD). We report here the phenotype of a patient referred for severe metabolic syndrome and cardiomyopathy, carrying a mutation in ZMPSTE24. The patient presented with a partial lipodystrophic syndrome associating hypertriglyceridemia, early onset type 2 diabetes, and android obesity with truncal and abdominal fat accumulation but without subcutaneous lipoatrophy...
2016: Cells
https://www.readbyqxmd.com/read/27113292/the-innovative-bio-oil-spread-prevents-metabolic-disorders-and-mediates-preconditioning-like-cardioprotection-in-rats
#15
A M Quintieri, E Filice, D Amelio, T Pasqua, F R Lupi, F Scavello, P Cantafio, C Rocca, A Lauria, C Penna, B De Cindio, M C Cerra, T Angelone
BACKGROUND AND AIMS: Obesity is often associated with an increased cardiovascular risk. The food industry and the associated research activities focus on formulating products that are a perfect mix between an adequate fat content and health. We evaluated whether a diet enriched with Bio-Oil Spread (SD), an olive oil-based innovative food, is cardioprotective in the presence of high-fat diet (HFD)-dependent obesity. METHODS AND RESULTS: Rats were fed for 16 weeks with normolipidic diet (ND; fat: 6...
July 2016: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/27106272/exenatide-decreases-liver-fat-content-and-epicardial-adipose-tissue-in-patients-with-obesity-and-type-2-diabetes-a-prospective-randomized-clinical-trial-using-magnetic-resonance-imaging-and-spectroscopy
#16
A Dutour, I Abdesselam, P Ancel, F Kober, G Mrad, P Darmon, O Ronsin, V Pradel, N Lesavre, J C Martin, A Jacquier, Y Lefur, M Bernard, B Gaborit
AIM: To conduct a prospective randomized trial to investigate the effect of glucagon-like peptide-1 (GLP-1) analogues on ectopic fat stores. METHODS: A total of 44 obese subjects with type 2 diabetes uncontrolled on oral antidiabetic drugs were randomly assigned to receive exenatide or reference treatment according to French guidelines. Epicardial adipose tissue (EAT), myocardial triglyceride content (MTGC), hepatic triglyceride content (HTGC) and pancreatic triglyceride content (PTGC) were assessed 45 min after a standardized meal with 3T magnetic resonance imaging and proton magnetic resonance spectroscopy before and after 26 weeks of treatment...
September 2016: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/27106042/chronic-plus-binge-ethanol-feeding-induces-myocardial-oxidative-stress-mitochondrial-and-cardiovascular-dysfunction-and-steatosis
#17
Csaba Matyas, Zoltan V Varga, Partha Mukhopadhyay, Janos Paloczi, Tamas Lajtos, Katalin Erdelyi, Balazs T Nemeth, Mintong Nan, Gyorgy Hasko, Bin Gao, Pal Pacher
Alcoholic cardiomyopathy in humans develops in response to chronic excessive alcohol consumption; however, good models of alcohol-induced cardiomyopathy in mice are lacking. Herein we describe mouse models of alcoholic cardiomyopathies induced by chronic and binge ethanol (EtOH) feeding and characterize detailed hemodynamic alterations, mitochondrial function, and redox signaling in these models. Mice were fed a liquid diet containing 5% EtOH for 10, 20, and 40 days (d) combined with single or multiple EtOH binges (5 g/kg body wt)...
June 1, 2016: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/27006481/fatty-acid-metabolic-defects-and-right-ventricular-lipotoxicity-in-human-pulmonary-arterial-hypertension
#18
Evan L Brittain, Megha Talati, Joshua P Fessel, He Zhu, Niki Penner, M Wade Calcutt, James D West, Mitch Funke, Gregory D Lewis, Robert E Gerszten, Rizwan Hamid, Meredith E Pugh, Eric D Austin, John H Newman, Anna R Hemnes
BACKGROUND: The mechanisms of right ventricular (RV) failure in pulmonary arterial hypertension (PAH) are poorly understood. Abnormalities in fatty acid (FA) metabolism have been described in experimental models of PAH, but systemic and myocardial FA metabolism has not been studied in human PAH. METHODS AND RESULTS: We used human blood, RV tissue, and noninvasive imaging to characterize multiple steps in the FA metabolic pathway in PAH subjects and controls. Circulating free FAs and long-chain acylcarnitines were elevated in PAH patients versus controls...
May 17, 2016: Circulation
https://www.readbyqxmd.com/read/26803593/biomarkers-and-prediction-of-myocardial-triglyceride-content-in-non-diabetic-men
#19
M Granér, S Gustavsson, K Nyman, R Siren, M O Pentikäinen, J Lundbom, A Hakkarainen, K Lauerma, N Lundbom, J Borén, M S Nieminen, M-R Taskinen
BACKGROUND AND AIMS: Lipid oversupply to cardiomyocytes or decreased utilization of lipids leads to cardiac steatosis. We aimed to examine the role of different circulating metabolic biomarkers as predictors of myocardial triglyceride (TG) content in non-diabetic men. METHODS AND RESULTS: Myocardial and hepatic TG contents were measured with 1.5 T magnetic resonance (MR) spectroscopy, and LV function, visceral adipose tissue (VAT), abdominal subcutaneous tissue (SAT), epicardial and pericardial fat by MR imaging in 76 non-diabetic men...
February 2016: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/26795240/comparative-proteomics-reveals-abnormal-binding-of-atgl-and-dysferlin-on-lipid-droplets-from-pressure-overload-induced-dysfunctional-rat-hearts
#20
COMPARATIVE STUDY
Linghai Li, Huina Zhang, Weiyi Wang, Yun Hong, Jifeng Wang, Shuyan Zhang, Shimeng Xu, Qingbo Shu, Juanfen Li, Fuquan Yang, Min Zheng, Zongjie Qian, Pingsheng Liu
Excessive retention of neutral lipids in cardiac lipid droplets (LDs) is a common observation in cardiomyopathy. Thus, the systematic investigation of the cardiac LD proteome will help to dissect the underlying mechanisms linking cardiac steatosis and myocardial dysfunction. Here, after isolation of LDs from normal and dysfunctional Sprague-Dawley rat hearts, we identified 752 heart-associated LD proteins using iTRAQ quantitative proteomic method, including 451 proteins previously unreported on LDs. The most noteworthy finding was the identification of the membrane resealing protein, dysferlin...
January 22, 2016: Scientific Reports
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