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myocardial steatosis

Roger Bedimo, Oladapo Abodunde
PURPOSE OF REVIEW: Fifteen to thirty percent of HIV-infected persons in North America and Europe are co-infected with chronic hepatitis C (HCV). The latter is associated with a significant number of extra-hepatic metabolic complications that could compound HIV-associated increased cardiovascular risk. This article reviews the basic science and epidemiologic and clinical evidence for increased cardio-metabolic risk among HIV/HCV-co-infected patients and discusses potential underlying mechanisms...
September 5, 2016: Current HIV/AIDS Reports
Francesca M Trovato, Giuseppe F Martines, Daniela Catalano, Giuseppe Musumeci, Clara Pirri, Guglielmo M Trovato
UNLABELLED: Non-alcoholic-fatty-liver-disease (NAFLD) is associated with atherosclerosis, increased cardiovascular risks and mortality. We investigated if, independently of insulin resistance, diet, physical activity and obesity, fatty liver involvement has any relationship with echocardiographic measurements in NAFLD. PATIENTS AND METHODS: 660 NAFLD and 791 non-NAFLD subjects, referred to the same out-patients medical unit for lifestyle-nutritional prescription, were studied...
October 15, 2016: International Journal of Cardiology
Eylem Levelt, Michael Pavlides, Rajarshi Banerjee, Masliza Mahmod, Catherine Kelly, Joanna Sellwood, Rina Ariga, Sheena Thomas, Jane Francis, Christopher Rodgers, William Clarke, Nikant Sabharwal, Charalambos Antoniades, Jurgen Schneider, Matthew Robson, Kieran Clarke, Theodoros Karamitsos, Oliver Rider, Stefan Neubauer
BACKGROUND: Type 2 diabetes (T2D) and obesity are associated with nonalcoholic fatty liver disease, cardiomyopathy, and cardiovascular mortality. Both show stronger links between ectopic and visceral fat deposition, and an increased cardiometabolic risk compared with subcutaneous fat. OBJECTIVES: This study investigated whether lean patients (Ln) with T2D exhibit increased ectopic and visceral fat deposition and whether these are linked to cardiac and hepatic changes...
July 5, 2016: Journal of the American College of Cardiology
Agnieszka Polak, Ewa Harasim, Adrian Chabowski
Endocannabinoids exert their effect on the regulation of energy homeostasis via activation of specific receptors. They control food intake, secretion of insulin, lipids and glucose metabolism, lipid storage. Long chain fatty acids are the main myocardial energy substrate. However, the heart exerts enormous metabolic flexibility emphasized by its ability to utilzation not only fatty acids, but also glucose, lactate and ketone bodies. Endocannabinoids can directly act on the cardiomyocytes through the CB1 and CB2 receptors present in cardiomyocytes...
2016: Postȩpy Higieny i Medycyny Doświadczalnej
Damien Galant, Bénédicte Gaborit, Camille Desgrouas, Ines Abdesselam, Monique Bernard, Nicolas Levy, Françoise Merono, Catherine Coirault, Patrice Roll, Arnaud Lagarde, Nathalie Bonello-Palot, Patrice Bourgeois, Anne Dutour, Catherine Badens
ZMPSTE24 encodes the only metalloprotease, which transforms prelamin into mature lamin A. Up to now, mutations in ZMPSTE24 have been linked to Restrictive Dermopathy (RD), Progeria or Mandibulo-Acral Dysplasia (MAD). We report here the phenotype of a patient referred for severe metabolic syndrome and cardiomyopathy, carrying a mutation in ZMPSTE24. The patient presented with a partial lipodystrophic syndrome associating hypertriglyceridemia, early onset type 2 diabetes, and android obesity with truncal and abdominal fat accumulation but without subcutaneous lipoatrophy...
2016: Cells
A M Quintieri, E Filice, D Amelio, T Pasqua, F R Lupi, F Scavello, P Cantafio, C Rocca, A Lauria, C Penna, B De Cindio, M C Cerra, T Angelone
BACKGROUND AND AIMS: Obesity is often associated with an increased cardiovascular risk. The food industry and the associated research activities focus on formulating products that are a perfect mix between an adequate fat content and health. We evaluated whether a diet enriched with Bio-Oil Spread (SD), an olive oil-based innovative food, is cardioprotective in the presence of high-fat diet (HFD)-dependent obesity. METHODS AND RESULTS: Rats were fed for 16 weeks with normolipidic diet (ND; fat: 6...
July 2016: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
A Dutour, I Abdesselam, P Ancel, F Kober, G Mrad, P Darmon, O Ronsin, V Pradel, N Lesavre, J C Martin, A Jacquier, Y Lefur, M Bernard, B Gaborit
AIM: To conduct a prospective randomized trial to investigate the effect of glucagon-like peptide-1 (GLP-1) analogues on ectopic fat stores. METHODS: A total of 44 obese subjects with type 2 diabetes uncontrolled on oral antidiabetic drugs were randomly assigned to receive exenatide or reference treatment according to French guidelines. Epicardial adipose tissue (EAT), myocardial triglyceride content (MTGC), hepatic triglyceride content (HTGC) and pancreatic triglyceride content (PTGC) were assessed 45 min after a standardized meal with 3T magnetic resonance imaging and proton magnetic resonance spectroscopy before and after 26 weeks of treatment...
September 2016: Diabetes, Obesity & Metabolism
Csaba Matyas, Zoltan V Varga, Partha Mukhopadhyay, Janos Paloczi, Tamas Lajtos, Katalin Erdelyi, Balazs T Nemeth, Mintong Nan, Gyorgy Hasko, Bin Gao, Pal Pacher
Alcoholic cardiomyopathy in humans develops in response to chronic excessive alcohol consumption; however, good models of alcohol-induced cardiomyopathy in mice are lacking. Herein we describe mouse models of alcoholic cardiomyopathies induced by chronic and binge ethanol (EtOH) feeding and characterize detailed hemodynamic alterations, mitochondrial function, and redox signaling in these models. Mice were fed a liquid diet containing 5% EtOH for 10, 20, and 40 days (d) combined with single or multiple EtOH binges (5 g/kg body wt)...
June 1, 2016: American Journal of Physiology. Heart and Circulatory Physiology
Evan L Brittain, Megha Talati, Joshua P Fessel, He Zhu, Niki Penner, M Wade Calcutt, James D West, Mitch Funke, Gregory D Lewis, Robert E Gerszten, Rizwan Hamid, Meredith E Pugh, Eric D Austin, John H Newman, Anna R Hemnes
BACKGROUND: The mechanisms of right ventricular (RV) failure in pulmonary arterial hypertension (PAH) are poorly understood. Abnormalities in fatty acid (FA) metabolism have been described in experimental models of PAH, but systemic and myocardial FA metabolism has not been studied in human PAH. METHODS AND RESULTS: We used human blood, RV tissue, and noninvasive imaging to characterize multiple steps in the FA metabolic pathway in PAH subjects and controls. Circulating free FAs and long-chain acylcarnitines were elevated in PAH patients versus controls...
May 17, 2016: Circulation
M Granér, S Gustavsson, K Nyman, R Siren, M O Pentikäinen, J Lundbom, A Hakkarainen, K Lauerma, N Lundbom, J Borén, M S Nieminen, M-R Taskinen
BACKGROUND AND AIMS: Lipid oversupply to cardiomyocytes or decreased utilization of lipids leads to cardiac steatosis. We aimed to examine the role of different circulating metabolic biomarkers as predictors of myocardial triglyceride (TG) content in non-diabetic men. METHODS AND RESULTS: Myocardial and hepatic TG contents were measured with 1.5 T magnetic resonance (MR) spectroscopy, and LV function, visceral adipose tissue (VAT), abdominal subcutaneous tissue (SAT), epicardial and pericardial fat by MR imaging in 76 non-diabetic men...
February 2016: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
Linghai Li, Huina Zhang, Weiyi Wang, Yun Hong, Jifeng Wang, Shuyan Zhang, Shimeng Xu, Qingbo Shu, Juanfen Li, Fuquan Yang, Min Zheng, Zongjie Qian, Pingsheng Liu
Excessive retention of neutral lipids in cardiac lipid droplets (LDs) is a common observation in cardiomyopathy. Thus, the systematic investigation of the cardiac LD proteome will help to dissect the underlying mechanisms linking cardiac steatosis and myocardial dysfunction. Here, after isolation of LDs from normal and dysfunctional Sprague-Dawley rat hearts, we identified 752 heart-associated LD proteins using iTRAQ quantitative proteomic method, including 451 proteins previously unreported on LDs. The most noteworthy finding was the identification of the membrane resealing protein, dysferlin...
2016: Scientific Reports
Louisa C Howard, Chia-Ying Liu, Julia B Purdy, Peter Walter, David A Bluemke, Colleen Hadigan
CONTEXT: Individuals with HIV have an elevated risk for developing cardiovascular disease compared to controls, particularly in relationship to abnormal deposition of lipid within various body compartments. Dysregulation of lipolysis may contribute to abnormal deposition of lipid in non-adipose tissues such as the heart, leading to untoward health consequences. OBJECTIVE: To evaluate potential relationships between rates of whole-body lipolysis and intramyocardial lipid content in HIV-infected subjects compared to healthy controls...
January 2016: Journal of Clinical Endocrinology and Metabolism
Inès Abdesselam, Pauline Pepino, Thomas Troalen, Michael Macia, Patricia Ancel, Brice Masi, Natacha Fourny, Bénédicte Gaborit, Benoît Giannesini, Frank Kober, Anne Dutour, Monique Bernard
BACKGROUND: Cardiovascular complications of obesity and diabetes are major health problems. Assessing their development, their link with ectopic fat deposition and their flexibility with therapeutic intervention is essential. The aim of this study was to longitudinally investigate cardiac alterations and ectopic fat accumulation associated with diet-induced obesity using multimodal cardiovascular magnetic resonance (CMR) in mice. The second objective was to monitor cardiac response to exendin-4 (GLP-1 receptor agonist)...
2015: Journal of Cardiovascular Magnetic Resonance
Jinfeng Ti, Lu Zhang, Zhijie Li, Dandan Zhao, Ying Zhang, Fang Li, Youxiang Diao
Duck Tembusu virus (TMUV) is an emerging flavivirus that has caused variable levels of outbreaks in poultry in recent years. In order to study the effect of age and inoculation routes on the TMUV infection, one hundred healthy domestic 5-day-old and 20-day-old goslings were equally divided into five groups and four experimental groups of goslings were infected with the TMUV-SDSG strain by intravenous and intranasal routes, respectively. Severe clinical signs were observed in goslings infected at 5 days of age, including listlessness, growth retardation, severe neurological dysfunction and even death...
December 31, 2015: Veterinary Microbiology
Eylem Levelt, Masliza Mahmod, Stefan K Piechnik, Rina Ariga, Jane M Francis, Christopher T Rodgers, William T Clarke, Nikant Sabharwal, Jurgen E Schneider, Theodoros D Karamitsos, Kieran Clarke, Oliver J Rider, Stefan Neubauer
Concentric left ventricular (LV) remodeling is associated with adverse cardiovascular events and is frequently observed in patients with type 2 diabetes mellitus (T2DM). Despite this, the cause of concentric remodeling in diabetes per se is unclear, but it may be related to cardiac steatosis and impaired myocardial energetics. Thus, we investigated the relationship between myocardial metabolic changes and LV remodeling in T2DM. Forty-six nonhypertensive patients with T2DM and 20 matched control subjects underwent cardiovascular magnetic resonance to assess LV remodeling (LV mass-to-LV end diastolic volume ratio), function, tissue characterization before and after contrast using T1 mapping, and (1)H and (31)P magnetic resonance spectroscopy for myocardial triglyceride content (MTG) and phosphocreatine-to-ATP ratio, respectively...
January 2016: Diabetes
Christoph Heier, Franz P W Radner, Tarek Moustafa, Renate Schreiber, Susanne Grond, Thomas O Eichmann, Martina Schweiger, Albrecht Schmidt, Ines K Cerk, Monika Oberer, H-Christian Theussl, Jacek Wojciechowski, Josef M Penninger, Robert Zimmermann, Rudolf Zechner
The anabolism and catabolism of myocardial triacylglycerol (TAG) stores are important processes for normal cardiac function. TAG synthesis detoxifies and stockpiles fatty acids to prevent lipotoxicity, whereas TAG hydrolysis (lipolysis) remobilizes fatty acids from endogenous storage pools as energy substrates, signaling molecules, or precursors for complex lipids. This study focused on the role of G0/G1 switch 2 (G0S2) protein, which was previously shown to inhibit the principal TAG hydrolase adipose triglyceride lipase (ATGL), in the regulation of cardiac lipolysis...
October 23, 2015: Journal of Biological Chemistry
Laura Serres, Philippe Vasseur, David Tougeron, Elise Gand, Carine Chagneau-Derrode, Florian Charier, Sophie Rochd, Christine Silvain
BACKGROUND AND AIMS: Chronic hepatitis C is also a metabolic disease that may increase cardiovascular events. FibroScan is a diagnostic tool for fibrosis and a prognostic tool for cirrhosis complications and mortality. The aim of our study was to investigate the prognostic value of liver stiffness evolution and initial stiffness in cardiovascular events occurring in patients with chronic hepatitis C. PATIENTS AND METHODS: Between 2006 and 2013, chronic hepatitis C patients followed in a reference center with two valid liver stiffness measurements by FibroScan were included...
November 2015: European Journal of Gastroenterology & Hepatology
Vaibhav B Patel, Jun Mori, Brent A McLean, Ratnadeep Basu, Subhash K Das, Tharmarajan Ramprasath, Nirmal Parajuli, Josef M Penninger, Maria B Grant, Gary D Lopaschuk, Gavin Y Oudit
Obesity is increasing in prevalence and is strongly associated with metabolic and cardiovascular disorders. The renin-angiotensin system (RAS) has emerged as a key pathogenic mechanism for these disorders; angiotensin (Ang)-converting enzyme 2 (ACE2) negatively regulates RAS by metabolizing Ang II into Ang 1-7. We studied the role of ACE2 in obesity-mediated cardiac dysfunction. ACE2 null (ACE2KO) and wild-type (WT) mice were fed a high-fat diet (HFD) or a control diet and studied at 6 months of age. Loss of ACE2 resulted in decreased weight gain but increased glucose intolerance, epicardial adipose tissue (EAT) inflammation, and polarization of macrophages into a proinflammatory phenotype in response to HFD...
January 2016: Diabetes
Gloria Mazzali, Francesco Fantin, Elena Zoico, Anna Sepe, Clara Bambace, Silvia Faccioli, Martina Pedrotti, Francesca Corzato, Vanni Rizzatti, Giuseppe Faggian, Rocco Micciolo, Saverio Cinti, Francesco Santini, Mauro Zamboni
CONTEXT: Fat may accumulate around the heart in epicardial adipose tissue or inside the heart as lipid droplets (LDs). OBJECTIVE: To compare myocardial steatosis between subjects with and without coronary artery disease (CAD and non-CAD) and to identify which cells contain LDs. DESIGN: Body mass index, waist circumference, glucose, insulin, homeostasis model assessment index, leptin, adiponectin, and high-sensitivity C-reactive protein were evaluated in CAD and non-CAD subjects...
September 2015: Journal of Clinical Endocrinology and Metabolism
Raquel Dilguerian de Oliveira Conceição, Antonio Gabriele Laurinavicius, Nea Miwa Kashiwagi, José Antonio Maluf de Carvalho, Carlos Alberto Garcia Oliva, Raul Dias Santos Filho
OBJECTIVE: To evaluate the impact of traditional check-up appointment on the progression of the cardiovascular risk throughout time. METHODS: This retrospective cohort study included 11,126 medical records of asymptomatic executives who were evaluated between January, 2005 and October, 2008. Variables included participants' demographics characteristics, smoking habit, history of cardiovascular diseases, diabetes, dyslipidemia, total cholesterol, HDL, triglycerides, glucose, c-reactive protein, waist circumference, hepatic steatosis, Framingham score, metabolic syndrome, level of physical activity, stress, alcohol consumption, and body mass index...
April 2015: Einstein
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