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https://www.readbyqxmd.com/read/29225701/cytotoxic-escherichia-coli-strains-encoding-colibactin-and-cytotoxic-necrotizing-factor-cnf-colonize-laboratory-macaques
#1
Yan Feng, Anthony Mannion, Carolyn M Madden, Alton G Swennes, Catherine Townes, Charles Byrd, Robert P Marini, James G Fox
Background: Many Escherichia coli strains are considered to be a component of the normal flora found in the human and animal intestinal tracts. While most E. coli strains are commensal, some strains encode virulence factors that enable the bacteria to cause intestinal and extra-intestinal clinically-relevant infections. Colibactin, encoded by a genomic island (pks island), and cytotoxic necrotizing factor (CNF), encoded by the cnf gene, are genotoxic and can modulate cellular differentiation, apoptosis and proliferation...
2017: Gut Pathogens
https://www.readbyqxmd.com/read/29224507/three-anastomotic-techniques-following-laparoscopic-rectal-cancer-resection-our-experience-in-155-patients
#2
Mahtab Zanguie, Abbas Abdollahi, Roham Salek, Ali Jangjoo, Mehdi Jabbari Nooghabi, Hosein Shabahang, Hamed Golmohammadzadeh
PURPOSE: This study aimed to assess the impact of 3 anastomotic techniques after laparoscopic rectal cancer resection. METHODS: In a cross-sectional study, the data of 155 patients who underwent surgery for rectal cancer were retrieved. An anastomosis was created between the left colon and anal canal with 3 different methods: coloanal anastomosis with protective ileostomy (group A), coloanal anastomosis without ostomy (group B), and delayed coloanal anastomosis (group C)...
December 1, 2017: Surgical Innovation
https://www.readbyqxmd.com/read/29224284/-clinicopathologic-features-of-lynch-syndrome-with-endometrial-carcinoma-combined-with-gastric-cancer-colon-cancer-and-rectal-cancer-report-of-a-case
#3
L Wang, H Ye, X H Zhu, W W Li
No abstract text is available yet for this article.
December 8, 2017: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/29223019/are-pathological-high-risk-features-in-locally-advanced-rectal-cancer-a-useful-selection-tool-for-adjuvant-chemotherapy
#4
Marloes Swets, Peter J K Kuppen, Erik J Blok, Hans Gelderblom, Cornelis J H van de Velde, Iris D Nagtegaal
BACKGROUND: Several histological high-risk factors are used as an indication for adjuvant therapy in stage II colon cancer. Those and other factors, including lymphatic invasion, perineural invasion (PNI), venous invasion and tumour budding are associated with decreased outcome. In this study, we evaluated the prognostic and predictive values of these biomarkers in a cohort of rectal cancer patients. MATERIALS AND METHODS: The trial-based cohort consisted of 221npTNM stage II-III rectal cancer patients, included in the PROCTOR/SCRIPT trial, a multicentre randomised phase III trial...
December 6, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/29208881/clinicopathological-assessment-of-colorectal-carcinoma-in-mymensingh-medical-college-hospital-bangladesh
#5
M M Mahamud, F Wahed, J Ferdous, M K Khan
Colorectal carcinoma (CRC) is the third most commonly diagnosed cancer and the third leading cause of cancer death in both men and women in the US. It is mainly a disease of the developed countries with a western culture, yet the disease is not uncommon in developing countries. There is substantial geographical variation in the incidence and demographic characteristics of the disease. Variations are also observed in the risk factors, mode of presentation, sub site distribution and stage of the disease at presentation...
October 2017: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/29207857/diagnosis-and-management-of-rectal-neuroendocrine-tumors
#6
REVIEW
Shreya Chablaney, Zachary A Zator, Nikhil A Kumta
The incidence of rectal neuroendocrine tumors (NETs) has increased by almost ten-fold over the past 30 years. There has been a heightened awareness of the malignant potential of rectal NETs. Fortunately, many rectal NETs are discovered at earlier stages due to colon cancer screening programs. Endoscopic ultrasound is useful in assessing both residual tumor burden after retrospective diagnosis and tumor characteristics to help guide subsequent management. Current guidelines suggest endoscopic resection of rectal NETs ≤10 mm as a safe therapeutic option given their low risk of metastasis...
November 2017: Clinical Endoscopy
https://www.readbyqxmd.com/read/29204164/comparison-of-dose-volume-parameters-evaluated-using-three-forward-planning-optimization-techniques-in-cervical-cancer-brachytherapy-involving-two-applicators
#7
Bikramjit Chakrabarti, Somapriya Basu-Roy, Sanjay Kumar Kar, Sounik Das, Annesha Lahiri
Purpose: This study is intended to compare dose-volume parameters evaluated using different forward planning- optimization techniques, involving two applicator systems in intracavitary brachytherapy for cervical cancer. It looks for the best applicator-optimization combination to fulfill recommended dose-volume objectives in different high-dose-rate (HDR) fractionation schedules. Material and methods: We used tandem-ring and Fletcher-style tandem-ovoid applicator in same patients in two fractions of brachytherapy...
October 2017: Journal of Contemporary Brachytherapy
https://www.readbyqxmd.com/read/29203993/minimally-invasive-surgery-for-rectal-cancer-current-status-and-future-perspectives
#8
REVIEW
Chinock Cheong, Nam Kyu Kim
Although laparoscopic resection for colon cancer has been proven safe and feasible when compared with open resection, currently no clear evidence is available regarding minimally invasive surgery for rectal cancer. This type of surgery may benefit patients by allowing fast recovery of normal dietary intake and bowel function, reduced postoperative pain, and shorter hospitalization. Therefore, minimally invasive surgeries such as laparoscopic or robot surgery have become the predominant treatment option for colon cancer...
December 2017: Indian Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29197194/the-role-of-self-expandable-metallic-stents-as-bridge-to-surgery-for-the-treatment-of-acute-malignant-colorectal-obstruction-our-experience
#9
Gianpasquale Gallo, Giuseppe Sammarco, Alessandro Paolo Chiriatti, Ferdinando Calabria, Rosario Sacco
INTRODUCTION: Despite the widespread use of screening programs, the colorectal cancer occurs in 7-29% of cases with a bowel obstruction, needing an immediate decompression treatment by emergency surgery; unfortunately, the emergency surgery is characterized by high morbidity and mortality rates. The endoscopic placement of self-expandable metallic stents can be a useful alternative, allowing to decompress the acute obstruction in a short time, in order to correct dehydration, electrolytic imbalance and to improve the overall clinical conditions prior to adequately plan the intervention of elective surgery...
2017: Annali Italiani di Chirurgia
https://www.readbyqxmd.com/read/29189663/decrease-of-sphincter-preserving-length-lowers-the-postoperative-genital-function-for-patients-with-rectal-cancer
#10
Zhihua Liu, Liang Kang, Meijin Huang, Chao Li, Chao Tong, Xingwei Zhang, Yanxin Luo, Lei Wang, Xiaojian Wu, Ping Lan, Ji Cui, Jianping Wang
BACKGROUND AND OBJECTIVE: With the increase in sphincter preserving rate of rectal cancer (RC) cancer, postoperative quality-of-life, such as genital dysfunction, has become a major issue in the patient management. In this study, we proposed a measurement, namely, the sphincter preserving length (SPL), and investigated the relationship between SPL and postoperative genital function and survival in RC patients. METHODS: A total of 536 male patients who had a diagnosis of RC and underwent sphincter preserving rectal resection in the Sixth Affiliated Hospital of Sun Yat-sen University and the First Affiliated Hospital of Sun Yat-sen University between October 1997 and December 2013 were included in our study...
November 16, 2017: Surgical Laparoscopy, Endoscopy & Percutaneous Techniques
https://www.readbyqxmd.com/read/29187431/microsatellite-instability-as-a-prognostic-factor-in-stage-ii-colon-cancer-patients-a-meta-analysis-of-published-literature
#11
REVIEW
Ioannis Gkekas, Jan Novotny, Ladislav Pecen, Karin Strigård, Richard Palmqvist, Ulf Gunnarsson
BACKGROUND/AIM: The prognostic role of microsatellite instability (MSI) in stage II colon cancer patients remains controversial despite the fact that it has been investigated in a number of studies. Hazard ratios differ considerably among these studies. We performed a meta-analysis to define the significance of MSI in this group of patients. MATERIALS AND METHODS: Studies indexed in PubMed presenting separate data on MSI status and survival outcomes for stage II colon cancer patients have been analyzed using fixed-effect meta-analysis of hazard ratio (HR) according to the method of Peto...
December 2017: Anticancer Research
https://www.readbyqxmd.com/read/29184690/correlation-of-tumor-mutational-burden-and-treatment-outcomes-in-patients-with-colorectal-cancer
#12
Sachin G Pai, Benedito A Carneiro, Young Kwang Chae, Ricardo L Costa, Aparna Kalyan, Hiral A Shah, Irene Helenowski, Alfred W Rademaker, Devalingam Mahalingam, Francis J Giles
Background: The Cancer Genome Atlas (TCGA) showed that 16% of colorectal cancers (CRCs) display DNA repair mechanisms and high tumor mutational burden (TMB). Although, there is accumulating evidence of greater benefit of immunotherapy in tumors with high-TMB, its impact on response to chemotherapy is unknown. Methods: In this retrospective cohort study, we investigated the impact of TMB on progression-free survival (PFS) of CRC patients treated at tertiary care oncology clinics who had their tumors profiled by next-generation sequencing (NGS)...
October 2017: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/29184474/neoadjuvant-strategies-locally-advanced-rectal-cancer
#13
REVIEW
Shahab Ahmed, Cathy Eng
Colorectal cancer is one of the major leading causes of death in both men and women. The successful management of colon or rectal cancer demands a multidisciplinary approach. In the last few years, significant improvement has been noticed in the management of localized rectal cancer to reduce local recurrence and obtain complete pathological response following appropriate surgical steps, if necessary. Implementation of neoadjuvant therapy not only enhances disease control, it may also ensure sphincter preserving procedures or organ-preserving options...
November 2017: Clinics in Colon and Rectal Surgery
https://www.readbyqxmd.com/read/29184464/new-horizons-in-rectal-cancer-management-in-colon-and-rectal-surgery
#14
Robert D Madoff
No abstract text is available yet for this article.
November 2017: Clinics in Colon and Rectal Surgery
https://www.readbyqxmd.com/read/29182902/a-clinical-case-of-perineal-invasion-from-rectal-carcinoma
#15
A Mitrushi, S Bilali, V Bilali, F Mitrushi, E Mehmeti
We report a case of 62-year old women with skin infiltration in the perineal area after anterior rectal resection due to upper rectal cancer. Computed Tomography (CT) shows an intense infiltrative aspect of the lesion. The patient had a diffuse perineal infiltration predominantly at Levator Ani muscles and adhesions to the posterior parts of urinary bladder, uterus, vagina and perineal skin. The patient underwent surgery with colostomy to relieve the colonic tract due to obstruction and later was treated with chemo-radiation...
July 2017: Il Giornale di Chirurgia
https://www.readbyqxmd.com/read/29182103/association-of-mitochondrial-copy-number-variation-and-t16189c-polymorphism-with-colorectal-cancer-in-north-indian-population
#16
Bhupender Kumar, Zafar Iqbal Bhat, Savita Bansal, Sunil Saini, Afreen Naseem, Khushnuma Wahabi, Archana Burman, Geeta Trilok Kumar, Sundeep Singh Saluja, M Moshahid Alam Rizvi
Globally, colorectal cancer is the third most common type of cancer. Genetic instability leading to cancer development is one of the major causes for development of cancer. Alterations in mitochondrial genome, that is, mutations, single-nucleotide polymorphisms, and copy number variations are known to contribute in cancer development. The aim of our study was to investigate association of mitochondrial T16189C polymorphism and copy number variation with colorectal cancer in North Indian population. DNA isolated from peripheral blood of 126 colorectal cancer patients and 114 healthy North Indian subjects was analyzed for T16189C polymorphism and half of them for mitochondrial copy number variation...
November 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/29181680/the-impact-of-primary-tumor-location-on-long-term-survival-in-patients-undergoing-hepatic-resection-for-metastatic-colon-cancer
#17
John M Creasy, Eran Sadot, Bas Groot Koerkamp, Joanne F Chou, Mithat Gonen, Nancy E Kemeny, Leonard B Saltz, Vinod P Balachandran, T Peter Kingham, Ronald P DeMatteo, Peter J Allen, William R Jarnagin, Michael I D'Angelica
BACKGROUND: The impact of primary tumor location on overall survival (OS), recurrence-free survival (RFS), and long-term outcomes has not been well established in patients undergoing potentially curative resection of colorectal liver metastases (CRLM). METHODS: A single-institution database was queried for initial resections for CRLM 1992-2004. Primary tumor location determined by chart review (right = cecum to transverse; left = splenic flexure to sigmoid)...
November 27, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29180604/classifying-colorectal-cancer-by-tumor-location-rather-than-sidedness-highlights-a-continuum-in-mutation-profiles-and-consensus-molecular-subtypes
#18
Jonathan M Loree, Allan Al Pereira, Michael Lam, Alexandra N Willauer, Kanwal Raghav, Arvind Dasari, Van K Morris, Shailesh M Advani, David G Menter, Cathy Eng, Kenna Shaw, Russell Broaddus, Mark J Routbort, Yusha Liu, Jeffrey Morris, Rajyalakshmi Luthra, Funda Meric-Bernstam, Michael J Overman, Dipen M Maru, Scott Kopetz
PURPOSE: Colorectal cancers (CRCs) are classified as right/left sided based on whether they occur before/after the splenic flexure, with established differences in molecular subtypes and outcomes.  However, it is unclear if this division is optimal and whether precise tumor location provides further information. EXPERIMENTAL DESIGN: In 1,876 patients with CRC we compared mutation prevalence and overall survival (OS) according to side and location. Consensus Molecular Subtype (CMS) was compared in a separate cohort of 608 patients...
November 27, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29179513/the-impacts-of-surgery-of-the-primary-cancer-and-radiotherapy-on-the-survival-of-patients-with-metastatic-rectal-cancer
#19
Duo Tong, Fei Liu, Wenhua Li, Wen Zhang
The role of surgery of the primary cancer and radiation in metastatic colorectal cancer (mCRC) is still controversial currently, and evidence implied that colon cancer (CC) and rectal cancer (RC) should be treated with difference. Hence we focused on metastatic rectal cancer (mRC) solely to compare the cancer cause-specific survival (CSS) of patients receiving varied treatments of the primary cancer: no treatment, surgery only, radiation only, and surgery plus radiation, based on the records of the Surveillance, Epidemiology, and End Results (SEER) database...
October 24, 2017: Oncotarget
https://www.readbyqxmd.com/read/29178096/-risk-factors-and-outcomes-of-postoperative-delirium-in-colorectal-cancer-patients-over-60-years
#20
Haitao Zhang, Yuanzhi Tang, Ying Qin
OBJECTIVE: To determine the incidence, risk factors and clinical outcomes of postoperative delirium in colorectal cancer patients over 60 years. METHODS: Consecutive 382 patients older than 60 years undergoing colorectal cancer surgery at Shenzhen Second People's Hospital from June 2013 to June 2016 were recruited prospectively in this study. These patients were evaluated daily after surgery for 7 days by confusion assessment method. Clinical outcomes were compared between patients with and without postoperative delirium, including postoperative complications, length of hospital stay, and mortality within 30 days...
November 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
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