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https://www.readbyqxmd.com/read/29026008/abdominal-obesity-and-colorectal-cancer-risk-systematic-review-and-meta-analysis-of-prospective-studies
#1
Yunlong Dong, Jiao Zhou, Yun Zhu, Tao He, Hong Hu, Hao Liu, Dan Luo, Shuanglan Xu, Lifen Xu, Jun Zhang, Zhaowei Teng
The association between abdominal obesity (as measured by waist circumference (WC) and waist to hip ratio (WHR)) and colorectal cancer (CRC) has not been fully quantified, and the magnitude of CRC risk associated with abdominal obesity is still unclear. A meta-analysis of prospective studies was performed to elucidate the CRC risk associated with abdominal obesity. Pubmed and Embase were searched for studies assessing the association between abdominal obesity and CRC risk. Relative risks (RRs) with 95% confidence intervals (95%CIs) were pooled using random-effects model of meta-analysis...
October 12, 2017: Bioscience Reports
https://www.readbyqxmd.com/read/29025530/intensive-follow-up-after-curative-surgery-for-colorectal-cancer
#2
Rita Vale Rodrigues, João Pereira da Silva, Isadora Rosa, Isabel Santos, Nuno Pereira, Carla Soares, António Dias Pereira
INTRODUCTION: The purpose of postoperative surveillance programs after curative treatment for colorectal cancer is to detect asymptomatic recurrences with the premise that an important rate will be eligible for curative resection, improving overall survival. We have implemented a surveillance program for patients with colorectal cancer, stages II-III, with periodic clinical, carcinoembryonic antigen and cancer antigen-19-9 assessment, computed tomography and colonoscopy. The aim of this study was to assess the rate of curative treatment of recurrence, colorectal cancer mortality and clinical characteristics associated with non-resectable recurrence...
September 29, 2017: Acta Médica Portuguesa
https://www.readbyqxmd.com/read/29025130/domain-specific-physical-activity-and-sedentary-behaviour-in-relation-to-colon-and-rectal-cancer-risk-a-systematic-review-and-meta-analysis
#3
Shahid Mahmood, Robert J MacInnis, Dallas R English, Amalia Karahalios, Brigid M Lynch
Background: Physical activity is associated with reduced risk of colorectal cancer, but most epidemiological studies have focused on occupational and recreational physical activity. The evidence for other domains of activity, and for sedentary behaviour, is limited. Methods: Medline, Embase and Web of Science were searched from inception to December 2015 for studies examining domain-specific physical activity or sedentary behaviour and the risk of colon and/or rectal cancer...
August 25, 2017: International Journal of Epidemiology
https://www.readbyqxmd.com/read/29025095/the-mediterranean-diet-and-risk-of-colorectal-cancer-in-the-uk-women-s-cohort-study
#4
Petra Jones, Janet E Cade, Charlotte E L Evans, Neil Hancock, Darren C Greenwood
Background: Evidence from epidemiological studies investigating associations between adherence to the Mediterranean diet and colorectal cancer is inconsistent. The aim of this study is to assess in the UK Women's Cohort Study whether adherence to the Mediterranean dietary pattern is associated with reduced incidence of cancers of the colon and rectum. Method: A total of 35 372 women were followed for a median of 17.4 years. A 10-component score indicating adherence to the Mediterranean diet was generated for each cohort participant, using a 217-item food frequency questionnaire...
August 19, 2017: International Journal of Epidemiology
https://www.readbyqxmd.com/read/29023686/body-fatness-at-an-early-age-and-risk-of-colorectal-cancer
#5
Khemayanto Hidayat, Chun-Mei Yang, Bi-Min Shi
While there is convincing evidence that excess body fatness in adulthood is positively associated with colorectal cancer risk, the association between body fatness at an early age (≤30 years) and the risk of colorectal cancer has been equivocal. The present meta-analysis was performed to clarify this association. PubMed and Web of Science databases were searched for relevant studies that investigated this association. The risk estimates from each study were transformed into a continuous variable for each 5 kg/m(2) increase in body mass index (BMI)...
October 12, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28993920/laparoscopic-lymph-node-dissection-around-the-inferior-mesenteric-artery-for-left-sided-colon-and-rectal-cancer
#6
Hidekazu Takahashi, Naotsugu Haraguchi, Junichi Nishimura, Taishi Hata, Chu Matsuda, Hirofumi Yamamoto, Tsunekazu Mizushima, Yuichiro Doki, Masaki Mori
Lymph node dissection is a critical part of surgery for colorectal cancer. Japanese D3 and complete mesocolic excision are two unique principles for lymph node dissection in colorectal cancer. Laparoscopic surgery magnifies the targets and provides insight about the micro-anatomy through high-quality, high-definition imaging, which benefits the surgeon. Although laparoscopic colorectal resection is feasible, there is no universal procedure. We describe in detail the anatomy viewed during lymph node dissection around the inferior mesenteric artery...
October 9, 2017: Surgery Today
https://www.readbyqxmd.com/read/28987338/increasing-colorectal-cancer-incidence-trends-among-younger-adults-in-canada
#7
Darren R Brenner, Yibing Ruan, Eileen Shaw, Prithwish De, Steven J Heitman, Robert J Hilsden
Recent analyses in the United States have shown an overall decrease in the incidence of colorectal cancer despite contrasting increases in younger age groups. We examined whether these cohort trends are occurring in Canada. Age-specific trends in colon and rectal cancer incidence in Canada from the National Cancer Incidence Reporting System (1969-1992) and the Canadian Cancer Registry (1992-2012) were analyzed. We estimated annual percent changes (APC) with the Joinpoint Regression Program from the Surveillance Epidemiology, and End Results Program...
October 4, 2017: Preventive Medicine
https://www.readbyqxmd.com/read/28982515/robotic-total-pelvic-exenteration-with-intracorporeal-sigmoid-conduit-and-colostomy-step-by-step-technique
#8
Matthew J Maurice, Daniel Ramirez, Emre Gorgun, Georges-Pascal Haber
OBJECTIVE: To describe our technique for robotic total pelvic exenteration with intracorporeal sigmoid conduit and colostomy using the da Vinci Si robot. METHODS: Three 8-mm robotic ports and two 12-mm laparoscopic ports are placed in a "W" configuration, approximately 2-3 cm more cephalad than for radical prostatectomy (Fig. 1). The robot is docked between the legs with the patient in steep Trendelenburg. The ureters are dissected out from the iliac vessels to the rectovesical pouch, where they are clipped and transected...
July 2017: Urology
https://www.readbyqxmd.com/read/28977850/integrated-transcriptomic-analysis-of-distance-related-field-cancerization-in-rectal-cancer-patients
#9
Honglin Guo, Weigen Zeng, Lin Feng, Xuexin Yu, Ping Li, Kaitai Zhang, Zhixiang Zhou, Shujun Cheng
Field cancerization (FC) occurs in various epithelial carcinomas, including colorectal cancer, which indicates that the molecular events in carcinogenesis might occur in normal tissues extending from tumors. However, the transcriptomic characteristics of FC in colorectal cancer (CRC) remain largely unexplored. To investigate the changes in gene expression associated with proximity to the tumor, we analyzed the global gene expression profiles of cancer tissues and histologically normal tissues taken at various distances from the tumor (1 cm, 5 cm and the proximal end of the resected sample) from 32 rectal cancer patients...
September 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28967718/outcomes-after-non-cardiac-surgery-mortality-complications-disability-and-rehospitalization
#10
Bruno Amato, Mario Santoro, Giuseppe Giugliano, Giuseppe Servillo, Veronica Di Nardo, Lorenza Di Domenico, Rita Compagna, Raffaele Izzo
In the last 25 years, the number of patients aged ≥75 years undergoing non-cardiac surgery has greatly increased. In elderly patients, frailty is significantly associated with an increased risk of adverse events, functional decline, procedural complications, prolonged hospitalization, and mortality. The relationship between frailty and increased mortality and morbidity requires an appropriate tool of assessment to accurately quantify the patient's clinical and perioperative conditions. The preoperative evaluation of elderly patients candidate for non-cardiac surgery should include assessment of frailty, sarcopenia and malnutrition, as these are related to high surgical risk...
July 18, 2017: Monaldi Archives for Chest Disease, Archivio Monaldi Per le Malattie del Torace
https://www.readbyqxmd.com/read/28963779/automatic-segmentation-of-the-clinical-target-volume-and-organs-at-risk-in-the-planning-ct-for-rectal-cancer-using-deep-dilated-convolutional-neural-networks
#11
Kuo Men, Jianrong Dai, Yexiong Li
PURPOSE: Delineation of the clinical target volume (CTV) and organs at risk (OARs) is very important for radiotherapy but is time-consuming and prone to inter-observer variation. Here, we proposed a novel deep dilated convolutional neural network (DDCNN)-based method for fast and consistent auto-segmentation of these structures. METHODS: Our DDCNN method was an end-to-end architecture enabling fast training and testing. Specifically, it employed a novel multiple-scale convolutional architecture to extract multiple-scale context features in the early layers, which contain the original information on fine texture and boundaries and which are very useful for accurate auto-segmentation...
September 30, 2017: Medical Physics
https://www.readbyqxmd.com/read/28957370/colonoscopy-reduces-colorectal-cancer-mortality-a-multicenter-long-term-colonoscopy-based-cohort-study
#12
MULTICENTER STUDY
Ryota Niikura, Yoshihiro Hirata, Nobumi Suzuki, Atsuo Yamada, Yoku Hayakawa, Hirobumi Suzuki, Shinzo Yamamoto, Ryo Nakata, Junko Komatsu, Makoto Okamoto, Makoto Kodaira, Tomohiro Shinozaki, Mitsuhiro Fujishiro, Toshiaki Watanabe, Kazuhiko Koike
BACKGROUND: There are limited colonoscopy-based cohort data concerning the effectiveness of colonoscopy in reducing colorectal cancer deaths. The aim of this study was to clarify whether colonoscopy reduces colorectal cancer mortality. METHODS: A cohort of 18,816 patients who underwent colonoscopy without a diagnosis of colorectal cancer between 2001 and 2010 at high colonoscopy procedure volume centers was selected. Patient characteristics and colonoscopy findings were assessed...
2017: PloS One
https://www.readbyqxmd.com/read/28952277/risk-factors-predicting-colorectal-cancer-recurrence-following-initial-treatment-a-5-year-cohort-study
#13
Mohammad Zare-Bandamiri, Mohammad Fararouei, Shadi Zohourinia, Nima Daneshi, Mostafa Dianatinasab
Purpose: Recurrence is one of the most important factors influencing survival of colorectal cancer patients. Subjects and Methods: In this cohort study, clinical and demographic characteristics of 561 patients with colorectal cancer were collected from 2010 to 2015. Medical records and telephone interviews were used to define the patient’s clinical status including the date of any recurrence during the study period. The multivariate Cox model was used as the main strategy for analyzing data. Results: Some 239 (42...
September 27, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28951373/-enhanced-recovery-after-preserving-the-left-colonic-artery-during-laparoscopic-anterior-resection-for-rectal-cancer
#14
Yun-Geng Liu, Lei Zhang, Ji-Ran Huang, Jin-Rong Yi, Chuan-Fa Fang, Lai-Yang Xia, Hong-Quan Liu, Jian-Zhong Yi
OBJECTIVE: To evaluate the postoperative outcomes of preserving the left colonic artery during laparoscopic anterior resection for rectal cancer. METHODS: The clinicopathologic data of 91 rectal cancer patients (pathologic Stage II) undergoing laparoscopic anterior resection was retrospectively analyzed. During the surgeries, the left colonic artery was preserved in 40 patients (preserved group) and ligated in 51 patients (unpreserved group). The operating time, intraoperative blood loss, time to first flatus and defecation, duration of postoperative abdominal distension and pain, number of retrieved lymph nodes, ileum fistulation and anatomical leakage rate were compared between the two groups...
September 20, 2017: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/28949102/robotic-surgery-for-rectal-cancer
#15
REVIEW
Hiroaki Nozawa, Toshiaki Watanabe
Laparoscopic surgery has gained acceptance as a less invasive approach in the treatment of colon cancer. However, laparoscopic surgery for rectal cancer, particularly cancer of the lower rectum, is still challenging because of limited accessibility. Robotic surgery overcomes the limitations of laparoscopy associated with anatomy and offers certain advantages, including 3-D imaging, dexterity and ambidextrous capability, lack of tremors, motion scaling, and a short learning curve. Robotic rectal surgery has been reported to reduce conversion rates, particularly in low anterior resection, but it is associated with longer operative times than the conventional laparoscopic approach...
September 26, 2017: Asian Journal of Endoscopic Surgery
https://www.readbyqxmd.com/read/28948490/rectal-cancer-in-asian-vs-western-countries-why-the-variation-in-incidence
#16
REVIEW
Yanhong Deng
Colorectal cancer (CRC) is the third most common cancer worldwide. CRC has been thought to be less common in Asia compared to Western countries. However, the incidence rates of CRC in Asia are high and there is an increasing trend in the Asian population. Furthermore, colorectal cancer accounts for the greatest number of all incidences of CRC in Asia. The increasing adoption of a Western lifestyle, particularly in dietary habits, is likely the most important factor contributing to the rapid increase in colon cancer incidence; it is noteworthy that trends for rectal cancer were flat...
September 25, 2017: Current Treatment Options in Oncology
https://www.readbyqxmd.com/read/28947950/nuclear-expression-of-lysyl-oxidase-enzyme-is-an-independent-prognostic-factor-in-rectal-cancer-patients
#17
Na Liu, Thomas R Cox, Weiyingqi Cui, Gunnar Adell, Birgitta Holmlund, Jie Ping, Ingvar Jarlsfelt, Janine T Erler, Xiao-Feng Sun
Emerging evidence has implicated a pivotal role for lysyl oxidase (LOX) in cancer progression and metastasis. Whilst the majority of work has focused on the extracellular matrix cross-linking role of LOX, the exact function of intracellular LOX localisation remains unclear. In this study, we analysed the LOX expression patterns in the nuclei of rectal cancer patient samples and determined the clinical significance of this expression. Nuclear LOX expression was significantly increased in patient lymph node metastases compared to their primary tumours...
September 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/28947945/discovery-of-new-selenoureido-analogues-of-4-4-fluorophenylureido-benzenesulfonamide-as-carbonic-anhydrase-inhibitors
#18
Andrea Angeli, Damiano Tanini, Thomas S Peat, Lorenzo Di Cesare Mannelli, Gianluca Bartolucci, Antonella Capperucci, Carla Ghelardini, Claudiu T Supuran, Fabrizio Carta
A series of benzenesulfonamides bearing selenourea moieties was obtained considering the ureido-sulfonamide SLC-0111, in Phase I clinical trials as antitumor agent, as a lead molecule. All compounds showed interesting inhibition potencies against the physiologically relevant human (h) carbonic anhydrase (hCAs, EC 4.2.1.1) isoforms I, II, IV, and IX. The most flexible analogues in the series 14-19 showed low nanomolar inhibition constants against hCA I, II, and IX. We assessed selected compounds on the in vitro antioxidant properties and binding modes and evaluated ex vivo human prostate (PC3), breast (MDA-MB-231), and colon-rectal (HT-29) cancer cell lines both in normoxic and hypoxic conditions...
September 14, 2017: ACS Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28938662/meta-analysis-of-the-association-between-the-inflammatory-potential-of-diet-and-colorectal-cancer-risk
#19
Yu Fan, Xin Jin, Changfeng Man, Zhenjun Gao, Xiaoyan Wang
OBJECTIVES: The inflammatory potential of diet has been inconsistently linked to colorectal cancer (CRC) risk. This meta-analysis aimed to evaluate the association of the inflammatory potential of diet, as estimated by the dietary inflammatory index (DII) score, with CRC risk. MATERIALS AND METHODS: The PubMed and Embase databases were searched for relevant studies from inception to February 2017. All cohort and case-control studies investigating the association of the DII score with CRC risk were selected...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28935353/oncologic-significance-of-para-aortic-lymph-node-and-inferior-mesenteric-lymph-node-metastasis-in-sigmoid-and-rectal-adenocarcinoma
#20
Seung Hyung Lee, Jong Lyul Lee, Chan Wook Kim, Han Il Lee, Chang Sik Yu, Jin Cheon Kim
BACKGROUND: Recurrence patterns or survival in colorectal cancer patients might differ according to inferior mesenteric lymph node (IMLN) metastasis. However, few studies have compared para-aortic lymph node (PALN) metastasis and IMLN metastasis. The aim of the current study is to identify survival and recurrence patterns in patients with sigmoid colon and rectal adenocarcinoma with either PALN or IMLN metastasis and to evaluate the prognostic significance of PALN and IMLN metastasis...
September 7, 2017: European Journal of Surgical Oncology
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