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https://www.readbyqxmd.com/read/29682713/-risk-factors-of-anastomotic-leakage-after-anterior-resection-for-rectal-cancer-and-the-diagnostic-value-of-computed-tomography-signs-in-anastomotic-leakage
#1
Junling Zhang, Xiaochao Guo, Jixin Zhang, Jing Liu, Tao Wu, Pengyuan Wang, Guowei Chen, Yong Jiang, Yingchao Wu, Xin Wang
OBJECTIVE: To investigate the risk factors and computed tomography (CT) diagnostic accuracy of anastomotic leakage after resection of rectal cancer (Dixon). METHODS: This retrospective study was conducted in Peking University First Hospital from January 2013 to June 2015. A cohort of 452 patients with rectal cancer was enrolled in the study. All the patients underwent anterior resection. The relationship between clinical-pathological data (including sex, age, body mass index (BMI), presence of diabetes, hypohemoglobin (Hb<90 g/L), hypoalbuminemia (Alb<35 g/L), the distance from the lower edge of the tumors to the anus, tumor diameter, tumor differentiation, tumor TNM stage, neoadjuvant therapy status, ligation of the left colonic artery(LCA), preventive colostomy, and anastomotic leakage was analyzed retrospectively...
2018: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/29682709/-prevention-of-anastomotic-leakage-after-robotic-surgery-for-rectal-cancer
#2
Xiaohui Du, Xiaowei Xing
With popularity of robotic surgery system, robotic rectal cancer surgery is increasing. Precautionary measures of different perioperative periods should be taken to reduce the risk for anastomotic leakage. First, the general condition of patients should be acquainted and improved, and the risk for anastomotic leakage should be evaluated preoperatively. Preoperative neoadjuvant chemoradiotherapy may not increase the risk for anastomotic leakage after rectal surgery. The impact of routine bowel preparation to prevent anastomotic leakage needs to be verified further...
2018: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/29682704/-anastomotic-leakage-after-rectal-cancer-surgery-classification-and-management
#3
Pan Chi, Shenghui Huang
Many studies have focused on the identification of risk factors and prevention of anastomotic leakage following rectal cancer surgery. However, there is little knowledge regarding classification and management of anastomotic leakage in clinic. Herein, we reviewed and summarized the classification and management of anastomotic leakage after rectal cancer surgery. The relevant treatments of anastomotic leakage should be chosen based on patient's manifestation, including general and local reactions, anatomical location, and nature of the leakage (contained or free, controlled or uncontrolled leakage)...
2018: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/29679138/sexual-quality-of-life-body-image-distress-and-psychosocial-outcomes-in-colorectal-cancer-a-longitudinal-study
#4
Jennifer Barsky Reese, Elizabeth Handorf, Jennifer A Haythornthwaite
PURPOSE: The objectives were to assess changes in sexual QOL and body image distress over time and to examine longitudinal associations between sexual QOL and body image variables with psychosocial outcomes in a sample of colorectal cancer patients. METHODS: Participants (N = 141) completed a mail-based survey assessing sexual QOL [sexual distress (ISS), treatment impact on sexual function (SFQ), sexual function (FSFI; IIEF)], body image distress (BIS), and psychosocial outcomes [relationship quality (DAS-4), depressive symptoms (CESD-SF), and health-related QOL (HRQOL; FACT-C)]; 88 patients completed 6-month follow-up surveys (62%)...
April 20, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29676343/histopathological-report-of-colorectal-carcinoma-resections-a-5-year-audit-in-lagos
#5
Kabir Bolarinwa Badmos, Olorunda Rotimi, Abdulrazzaq Oluwagbemiga Lawal, Adedapo O Osinowo, Mohammed Y Habeebu, Fatimah Biade Abdulkareem
Background: Complete and accurate pathology reporting of colorectal carcinoma (CRC) resection specimen is critical to clinical management of individual patients. The study aims to audit colorectal cancer histopathology reporting in Lagos between 2011 and 2015 before the adoption of the Society for Gastroenterology and Hepatology in Nigeria pro forma in 2016. Materials and Methods: All resected CRC cases were identified from the Histopathology record of our Department and that of a private Laboratory in Lagos over a 5-year from 2011 to 2015...
January 2018: Nigerian Postgraduate Medical Journal
https://www.readbyqxmd.com/read/29675892/dna-repair-protein-xpa-is-differentially-expressed-in-colorectal-cancer-and-predicts-better-prognosis
#6
Xue Feng, Jingwei Liu, Yuehua Gong, Kaihua Gou, Huaiwei Yang, Yuan Yuan, Chengzhong Xing
As an indispensable factor in DNA damage recognition step of nucleotide excision repair, XPA interacts with a series of proteins to initiate repair process. The expression characteristics of XPA in colorectal cancer (CRC) and its influence on CRC prognosis remain elusive. Tissue specimens of CRC and nontumor adjacent tissues from 283 patients were collected. XPA protein expressions were detected by immunohistochemistry staining. Nonparametric test was used to investigate the difference of XPA expression between CRC and nontumor adjacent tissues, as well as the correlation between XPA expression and clinicopathological parameters of CRC...
April 19, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29667123/peritoneal-carcinomatosis-arising-from-rectal-or-colonic-adenocarcinoma-treated-with-cytoreductive-surgery-crs-hyperthermic-intraperitoneal-chemotherapy-hipec-two-different-diseases
#7
M Tonello, G Ortega-Perez, O Alonso-Casado, P Torres-Mesa, G Guiñez, S Gonzalez-Moreno
PURPOSE: Peritoneal carcinomatosis (PC) from colorectal cancer (CRC) has poor survival. Multi-modal treatment including systemic chemotherapy, cytoreductive surgery (CRS), and hyperthermic intraperitoneal chemotherapy (HIPEC) can be used in selected patients with curative intent. The majority published works consider PC of CRC origin as a homogenous disease. Aim of this study is to stress the different biological behaviors and survival of PC according to colonic or rectal origin. METHODS: Data of CRS and HIPEC procedures for PC of CRC origin performed at MD Anderson Cancer Center-Madrid (Spain) have been collected, dividing patients into two groups according to colonic or rectal PC...
April 17, 2018: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/29663399/multidimensional-analyses-of-the-learning-curve-for-single-incision-plus-one-port-laparoscopic-surgery-for-sigmoid-colon-and-upper-rectal-cancer
#8
Junmeng Li, Yanan Wang, Dong Liu, Haipeng Zhou, Tingyu Mou, Guoxin Li, Haijun Deng
BACKGROUND AND OBJECTIVES: Single-incision plus one port surgery (SILS + 1) provides the advantages of being minimally invasive and easier to perform than pure single-incision laparoscopic surgery. The aim of this study was to investigate the learning curve (LC) for SILS + 1 for sigmoid colon and upper rectal cancer. METHOD: From November 2012 to May 2014, a series of 85 consecutive patients underwent selective SLIS + 1 for sigmoid colon and upper rectal cancer performed by a single surgeon at Nanfang Hospital...
April 17, 2018: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29661279/sources-of-distress-among-patients-undergoing-surgery-for-colorectal-cancer-a-qualitative-study
#9
Jonathan S Abelson, Alanna Chait, Megan J Shen, Mary Charlson, Anna Dickerman, Heather L Yeo
BACKGROUND: Distress is common among cancer and surgical patients and can lead to worse outcomes if untreated. The objective of this study was to explore sources of distress among colorectal cancer patients undergoing surgery. MATERIALS AND METHODS: This was a qualitative study using in-depth, semistructured, one-on-one interviews in an academic setting. Patients were recruited if they had a pathologically confirmed diagnosis of colon or rectal cancer. Purposive sampling was used to recruit patients who were about to undergo (preoperative), or had recently undergone (postoperative), curative resection for colorectal cancer...
June 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29661174/diabetes-mellitus-and-the-risk-of-gastrointestinal-cancer-in-women-compared-with-men-a-meta-analysis-of-cohort-studies
#10
Hong-Juan Fang, Shao-Bo Shan, Yu-Hao Zhou, Li-Yong Zhong
BACKGROUND: The increasing epidemic proportions of diabetes mellitus (DM) are a major cause of premature illness and death. However, whether DM confers the same excess risk of gastrointestinal cancer for women as it does for men remains controversial. The purpose of this study was to estimate the relation between DM and gastrointestinal cancer in women compared with men after accounting for other major risk factors based on cohort studies. METHODS: We performed a meta-analysis of cohort studies published through May 2017 from PubMed, Embase, and the Cochrane Library...
April 16, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29650925/-a-case-of-colon-cancer-with-brain-liver-and-lung-metastasis-successfully-treated-with-bevacizumab-plus-xelox-therapy
#11
Tomokazu Tokoro, Keishi Nakamura, Atsushi Hirose, Shinichi Nakanuma, Kohichi Okamoto, Jun Kinoshita, Isamu Makino, Hironori Hayashi, Katsunobu Oyama, Tomoharu Miyashita, Hidehiro Tajima, Hiroyuki Takamura, Itasu Ninomiya, Sachio Fushida, Tetsuo Ohta
The patient was a 57-year-old woman. Preclinical examination of malignant lymphoma revealed 0-I sp type of early rectal cancer in the upper rectum, 20 cm from the anal margin. Endoscopic mucosal resection was performed and positive deep margins were pathologically diagnosed. Additional intestinal resection with lymph node dissection was deemed necessary, but ABVD therapy was initiated because the clinical stage of the malignant lymphoma was Stage III b or higher. Two months after detecting elevated CEA, S8 liver metastasis was pointed out, and examination of weakness of the right upper limb revealed nodular, multifocal brain metastasis...
March 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29650838/-two-cases-of-hepatic-encephalopathy-after-chemotherapy-for-metastatic-colorectal-cancer
#12
Tae Matsumura, Shingo Noura, Masaki Hirota, Yuki Ozato, Daiki Marukawa, Takashi Shuto, Arisa Muratsu, Akinobu Yasuyama, Akihiro Takata, Chikato Koga, Chizu Kameda, Masahiro Murakami, Ryohei Kawabata, Junzo Shimizu, Junichi Hasegawa
We reported 2 cases of hepatic encephalopathy after chemotherapy for advanced colorectal cancer. Case 1: A 49-year-old male was diagnosed advanced sigmoid colon cancer with peritoneal dissemination, multiple liver metastasis and multiple osseous metastasis. After resection of primary lesion, we administered mFOLFOX6 plus bevacizumab combination therapy. He was in comatose(Japan coma scale 200)3 days after 2 courses of administration of this regimen. Case 2: A 57-year-old female was diagnosed advanced rectal cancer with multiple huge liver metastasis and multiple osseous metastasis...
April 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29650830/-curative-resection-for-unresectable-locally-advanced-colorectal-cancer-following-intensive-chemotherapy-plus-molecular-targeted-agent-report-of-three-cases
#13
Yuto Hozaka, Shinichiro Mori, Yoshiaki Kita, Kenji Baba, Takaaki Arigami, Yoshikazu Uenosono, Yasuto Uchikado, Yuko Mataki, Kosei Maemura, Shoji Natsugoe
Intensive chemotherapy plus molecular targeted agent improve overall survival for patients with unresectable colorectal cancer.We performed laparoscopic surgery following intensive chemotherapy of mFOLFOX6 or FOLFIRI plus molecular targeted agent for 3 patients with unresectable locally advanced colorectal cancer with abscess formation.A 60-year-old man was diagnosed as having unresectable rectal cancer with abscess formation and underwent curative resection after partial response following chemotherapy.A 42-year-old woman was diagnosed as having unresectable sigmoid colon cancer with abscess formation and underwent curative resection after partial response following chemotherapy...
April 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29650827/-a-case-report-of-complete-resection-of-the-recurrence-small-intestinal-carcinoma-with-abdominal-wall-repair-using-femoral-fascia
#14
Tadafumi Fukata, Taishi Hata, Tateki Kubo, Naotsugu Haraguchi, Hidekazu Takahashi, Junichi Nishimura, Chu Matsuda, Tsunekazu Mizushima, Kou Hosokawa, Yuichiro Doki, Masaki Mori
The patients had Hartmann's operation for rectal cancer when she was 61 years old. After that, she underwent the operation for small bowel cancer when she was 68 years old. After 5 months, the only metastatic lesion was detected near the Scolon stoma. For the first therapy, She received chemotherapy(mFOLFOX6 plus bevacizumab)and had a reducing effect. She was introduced to our hospital for the purpose of resection of the recurrent lesion. CT scan detected a nodule near the Scolon stoma with FDG uptake for PET-CT scan...
April 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29650416/effect-of-comorbidities-in-stage-ii-iii-colorectal-cancer-patients-treated-with-surgery-and-neoadjuvant-adjuvant-chemotherapy-a-single-center-observational-study
#15
Marina Baretti, Lorenza Rimassa, Nicola Personeni, Laura Giordano, Maria Chiara Tronconi, Tiziana Pressiani, Silvia Bozzarelli, Armando Santoro
BACKGROUND: Comorbidity has a detrimental effect on cancer survival, however, it is difficult to disentangle its direct effect from its influence on treatment choice. In this study we assessed the effect of comorbidity on survival in patients who received standard treatment for resected stage II and III colorectal cancer (CRC). PATIENTS AND METHODS: In total, 230 CRC patients, 68 rectal (29.6%) and 162 colon cancer (70.4%) treated with surgical resection and neoadjuvant/adjuvant chemotherapy from December 2002 to December 2009 at Humanitas Cancer Center were retrospectively reviewed...
March 21, 2018: Clinical Colorectal Cancer
https://www.readbyqxmd.com/read/29649396/surgeons-perceived-barriers-to-palliative-and-end-of-life-care-a-mixed-methods-study-of-a-surgical-society
#16
Pasithorn A Suwanabol, Ari C Reichstein, Z Tuba Suzer-Gurtekin, Jane Forman, Maria J Silveira, Lona Mody, Arden M Morris
BACKGROUND: Nearly 20% of colorectal cancer (CRC) patients present with potentially incurable (Stage IV) disease, yet their physicians do not integrate cancer treatment with palliative care. Compared with patients treated by primary providers, surgical patients with terminal diseases are significantly less likely to receive palliative or end-of-life care. OBJECTIVE: To describe surgeon perspectives on palliative and end-of-life care for patients with Stage IV CRCs...
March 13, 2018: Journal of Palliative Medicine
https://www.readbyqxmd.com/read/29630003/use-of-primary-anastomosis-with-diverting-ileostomy-in-patients-with-acute-diverticulitis-requiring-urgent-operative-intervention
#17
Christy E Cauley, Ruchin Patel, Liliana Bordeianou
BACKGROUND: Previous studies suggest that urgent colectomy and primary anastomosis with diversion is safe for perforated diverticulitis. Current guidelines support this approach. OBJECTIVE: The purpose of this study was to describe the use of urgent or emergent primary anastomosis with diversion in diverticulitis before the 2014 American Society of Colon and Rectal Surgeons guidelines and compare national outcomes of primary anastomosis with diversion to the Hartmann procedure...
May 2018: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/29617381/prevention-of-colonic-neoplasia-with-polyethylene-glycol-a-short-term-randomized-placebo-controlled-double-blinded-trial
#18
Ramesh K Wali, Laura Bianchi, Sonia Kupfer, Mart De La Cruz, Borko Jovanovic, Christopher Weber, Michael J Goldberg, L M Rodriguez, Raymond Bergan, David Rubin, Mary Beth Tull, Ellen Richmond, Beth Parker, Seema Khan, Hemant K Roy
Chemoprevention represents an attractive modality against colorectal cancer (CRC) although widespread clinical implementation of promising agents (e.g. aspirin/NSAIDS) have been stymied by both suboptimal efficacy and concerns over toxicity. This highlights the need for better agents. Several groups, including our own, have reported that the over-the-counter laxative polyethylene glycol (PEG) has remarkable efficacy in rodent models of colon carcinogenesis. In this study, we undertook the first randomized human trial to address the role of PEG in prevention of human colonic neoplasia...
2018: PloS One
https://www.readbyqxmd.com/read/29615487/comparison-of-prognostic-models-to-predict-the-occurrence-of-colorectal-cancer-in-asymptomatic-individuals-a-systematic-literature-review-and-external-validation-in-the-epic-and-uk-biobank-prospective-cohort-studies
#19
Todd Smith, David C Muller, Karel G M Moons, Amanda J Cross, Mattias Johansson, Pietro Ferrari, Guy Fagherazzi, Petra H M Peeters, Gianluca Severi, Anika Hüsing, Rudolf Kaaks, Anne Tjonneland, Anja Olsen, Kim Overvad, Catalina Bonet, Miguel Rodriguez-Barranco, Jose Maria Huerta, Aurelio Barricarte Gurrea, Kathryn E Bradbury, Antonia Trichopoulou, Christina Bamia, Philippos Orfanos, Domenico Palli, Valeria Pala, Paolo Vineis, Bas Bueno-de-Mesquita, Bodil Ohlsson, Sophia Harlid, Bethany Van Guelpen, Guri Skeie, Elisabete Weiderpass, Mazda Jenab, Neil Murphy, Elio Riboli, Marc J Gunter, Krasimira Jekova Aleksandrova, Ioanna Tzoulaki
OBJECTIVE: To systematically identify and validate published colorectal cancer risk prediction models that do not require invasive testing in two large population-based prospective cohorts. DESIGN: Models were identified through an update of a published systematic review and validated in the European Prospective Investigation into Cancer and Nutrition (EPIC) and the UK Biobank. The performance of the models to predict the occurrence of colorectal cancer within 5 or 10 years after study enrolment was assessed by discrimination (C-statistic) and calibration (plots of observed vs predicted probability)...
April 3, 2018: Gut
https://www.readbyqxmd.com/read/29615301/early-onset-sporadic-colorectal-cancer-worrisome-trends-and-oncogenic-features
#20
REVIEW
Giulia Martina Cavestro, Alessandro Mannucci, Raffaella Alessia Zuppardo, Milena Di Leo, Elena Stoffel, Giovanni Tonon
Early onset colorectal cancers, defined as arising before 50 years of age, are a growing health hazard in western and eastern countries alike. The incidence of colon and rectal cancers in young individuals is projected to increase by as much as 90% and 140%, respectively, by 2030. Although several known cancer risk factors (e.g. smoking, alcohol, dietary habits) have been investigated, there is no single compelling explanation for this epidemiological trend. While some early onset colorectal cancers have been associated with germline mutations in cancer predisposition genes, genetic syndromes are implicated in only a fraction of these cancers (20%) and do not explain the rising incidence...
February 23, 2018: Digestive and Liver Disease
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