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https://www.readbyqxmd.com/read/29666782/new-perspectives-on-diagnosis-and-therapy-of-malignant-pleural-mesothelioma
#1
REVIEW
Marika Rossini, Paola Rizzo, Ilaria Bononi, Anthony Clementz, Roberto Ferrari, Fernanda Martini, Mauro G Tognon
Malignant pleural mesothelioma (MPM) is a rare, but severe form of cancer, with an incidence that varies significantly within and among different countries around the world. It develops in about one to two persons per million of the general population, leading to thousands of deaths every year worldwide. To date, the MPM is mostly associated with occupational asbestos exposure. Asbestos represents the predominant etiological factor, with approximately 70% of cases of MPM with well-documented occupational exposure to asbestos, with the exposure time, on average greater than 40 years...
2018: Frontiers in Oncology
https://www.readbyqxmd.com/read/29666607/exploring-biogeochemistry-and-microbial-diversity-of-extant-microbialites-in-mexico-and-cuba
#2
Patricia M Valdespino-Castillo, Ping Hu, Martín Merino-Ibarra, Luz M López-Gómez, Daniel Cerqueda-García, Roberto González-De Zayas, Teresa Pi-Puig, Julio A Lestayo, Hoi-Ying Holman, Luisa I Falcón
Microbialites are modern analogs of ancient microbial consortia that date as far back as the Archaean Eon. Microbialites have contributed to the geochemical history of our planet through their diverse metabolic capacities that mediate mineral precipitation. These mineral-forming microbial assemblages accumulate major ions, trace elements and biomass from their ambient aquatic environments; their role in the resulting chemical structure of these lithifications needs clarification. We studied the biogeochemistry and microbial structure of microbialites collected from diverse locations in Mexico and in a previously undescribed microbialite in Cuba...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29666277/disparate-binding-kinetics-by-an-intrinsically-disordered-domain-enables-temporal-regulation-of-transcriptional-complex-formation
#3
Neil O Robertson, Ngaio C Smith, Athina Manakas, Mahiar Mahjoub, Gordon McDonald, Ann H Kwan, Jacqueline M Matthews
Intrinsically disordered regions are highly represented among mammalian transcription factors, where they often contribute to the formation of multiprotein complexes that regulate gene expression. An example of this occurs with LIM-homeodomain (LIM-HD) proteins in the developing spinal cord. The LIM-HD protein LHX3 and the LIM-HD cofactor LDB1 form a binary complex that gives rise to interneurons, whereas in adjacent cell populations, LHX3 and LDB1 form a rearranged ternary complex with the LIM-HD protein ISL1, resulting in motor neurons...
April 16, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29665524/primary-hyperfibrinolysis-facts-and-fancies
#4
REVIEW
Massimo Franchini, Pier Mannuccio Mannucci
Fibrinolysis is a complex process that controls both hemostasis and thrombosis. The regulation of the fibrinolytic system is mediated through a wide array of cofactors and inhibitors that maintain the hemostatic balance in a delicate equilibrium. As a consequence, disturbances in the fibrinolysis pathway are associated with various disease states, ranging from thrombotic to hemorrhagic clinical phenotypes. In particular, a number of inherited and acquired disorders are associated with an enhanced fibrinolysis leading to a bleeding tendency that in some cases may be life-threatening...
April 12, 2018: Thrombosis Research
https://www.readbyqxmd.com/read/29662606/accouchement-g%C3%A3-mellaire-en-milieu-africain-une-analyse-de-10-ans-dans-le-district-de-bamako-au-mali-twin-deliveries-in-africa-10-years-analysis-in-bamako%C3%A2-s-district-in-mali
#5
Tiounkani Théra, Niani Mounkoro, Soumana Omar Traore, Albachar Hamidou, Mamadou Traore, Saleck Doumbia, Saoudatou Tall, Aminata Kouma
Introduction Aim: It was to determine the factors influencing the prognosis of the second twin's delivery. Methods: The study was retrospective and covered all cases of twin births registered at our maternity from 1st January 2007 to 31st December 2016 (10 years). Results: We recorded 34,899 deliveries among which 1374 twin deliveries (2.54%). Almost 15% were primiparous; 39.16% were referred; 69.10% and 15.5% without prenatal care. The factors negatively influencing prognosis for second twin were: a delay>15 minutes between twin deliveries, delayed caesarean section, non-qualification of the midwife, monochoreal, low birth weight...
2018: Pan African Medical Journal
https://www.readbyqxmd.com/read/29662207/tracing-the-ninth-sulfur-of-the-nitrogenase-cofactor-via-a-semi-synthetic-approach
#6
Kazuki Tanifuji, Chi Chung Lee, Nathaniel S Sickerman, Kazuyuki Tatsumi, Yasuhiro Ohki, Yilin Hu, Markus W Ribbe
The M-cluster is the [(homocitrate)MoFe7 S9 C] active site of nitrogenase that is derived from an 8Fe core assembled viacoupling and rearrangement of two [Fe4 S4 ] clusters concomitant with the insertion of an interstitial carbon and a 'ninth sulfur'. Combining synthetic [Fe4 S4 ] clusters with an assembly protein template, here we show that sulfite can give rise to the ninth sulfur that is incorporated in the catalytically important belt region of the cofactor after the radical S-adenosyl-L-methionine-dependent carbide insertion and the concurrent 8Fe-core rearrangement have already taken place...
April 16, 2018: Nature Chemistry
https://www.readbyqxmd.com/read/29662141/the-cytoplasmic-dynein-transport-machinery-and-its-many-cargoes
#7
REVIEW
Samara L Reck-Peterson, William B Redwine, Ronald D Vale, Andrew P Carter
Cytoplasmic dynein 1 is an important microtubule-based motor in many eukaryotic cells. Dynein has critical roles both in interphase and during cell division. Here, we focus on interphase cargoes of dynein, which include membrane-bound organelles, RNAs, protein complexes and viruses. A central challenge in the field is to understand how a single motor can transport such a diverse array of cargoes and how this process is regulated. The molecular basis by which each cargo is linked to dynein and its cofactor dynactin has started to emerge...
April 16, 2018: Nature Reviews. Molecular Cell Biology
https://www.readbyqxmd.com/read/29662099/lignin-peroxidase-ligand-access-channel-dysfunction-in-the-presence-of-atrazine
#8
János Ecker, László Fülöp
Studies have determined that the white-rot basidiomycete Phanerochaete chrysosporium is capable of biodegrading the atrazine herbicide with its broad-specificity enzymes, but the particular role of biocatalysts is still unclear. In the case of lignin peroxidase, a ligand access channel connected to the active heme cofactor provides access to the active site for potential small-sized substrates. Experimental results show that lignin peroxidase is unable to degrade atrazine, therefore, the primary goal was to determine whether there is any connection between the structural and dynamical properties of the enzyme and its incapability to degrade atrazine...
April 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29661938/dual-functionality-of-%C3%AE-tryptase-protomers-as-both-proteases-and-cofactors-in-the-active-tetramer
#9
Henry R Maun, Peter S Liu, Yvonne Franke, Charles Eigenbrot, William F Forrest, Lawrence B Schwartz, Robert A Lazarus
Human β-tryptase, a tetrameric trypsin-like serine protease, is an important mediator of the allergic inflammatory responses in asthma. During acute hypersensitivity reactions, mast cells degranulate, releasing active tetramer as a complex with proteoglycans. Extensive efforts have focused on developing therapeutic β-tryptase inhibitors, but its unique activation mechanism is less well explored. Tryptase is active only after proteolytic removal of the pro-domain followed by tetramer formation via two distinct symmetry-related interfaces...
April 16, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29660835/pdgfra-mrna-overexpression-is-associated-with-regional-metastasis-and-reduced-survival-in-oral-squamous-cell-carcinoma
#10
Hui Shan Ong, Sandhya Gokavarapu, Zhen Tian, Jiang Li, Qin Xu, Chen Ping Zhang, Wei Cao
BACKGROUND: Platelet-derived growth factor alpha (PDGFRA) is a gene encoding tyrosine kinase receptor and both EGFR and PDGFRA activate tyrosine kinase. The implication of PGFRA in many cancers and its prognostic significance irrespective to EGFR status in spinal chordoma, gliomas and uterine cancers has shown a need for its investigation in oral squamous cell carcinoma (OSCC). We investigated the prognostic value of PDGFRA mRNA expression in OSCC. PATIENTS AND METHODS: The study was conducted in the department of oral maxillofacial surgery-head and neck oncology, at a tertiary hospital...
April 16, 2018: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/29660187/increased-flexibility-in-the-use-of-exogenous-lipoic-acid-by-staphylococcus-aureus
#11
Irina Laczkovich, Wei Ping Teoh, Sarah Flury, James P Grayczyk, Azul Zorzoli, Francis Alonzo
Lipoic acid is a cofactor required for intermediary metabolism that is either synthesized de novo or acquired from environmental sources. The bacterial pathogen Staphylococcus aureus encodes enzymes required for de novo biosynthesis, but also encodes two ligases, LplA1 and LplA2, that are sufficient for lipoic acid salvage during infection. S. aureus also encodes two H proteins, GcvH of the glycine cleavage system and the homologous GcvH-L encoded in an operon with LplA2. GcvH is a recognized conduit for lipoyl transfer to α-ketoacid dehydrogenase E2 subunits, while the function of GcvH-L remains unclear...
April 16, 2018: Molecular Microbiology
https://www.readbyqxmd.com/read/29660073/creation-of-a-formate-malate-oxidoreductase-by-fusion-of-dehydrogenase-enzymes-with-pegylated-cofactor-swing-arms
#12
Harun F Ozbakir, Kristen E Garcia, Scott Banta
Enzymatic biocatalysis can be limited by the necessity of soluble cofactors. Here, we introduced PEGylated nicotinamide adenine dinucleotide (NAD(H)) swing arms to two covalently fused dehydrogenase enzymes to eliminate their nicotinamide cofactor requirements. A formate dehydrogenase and cytosolic malate dehydrogenase were connected via SpyCatcher-SpyTag fusions. Bifunctionalized polyethylene glycol chains tethered NAD(H) to the fusion protein. This produced a formate:malate oxidoreductase that exhibited cofactor-independent ping-pong kinetics with predictable Michaelis constants...
April 5, 2018: Protein Engineering, Design & Selection: PEDS
https://www.readbyqxmd.com/read/29659909/sexually-transmitted-bedfellows-exquisite-association-between-hiv-and-hsv2-in-21-communities-in-southern-africa-in-the-hptn-071-popart-study
#13
J Bradley, S Floyd, E Piwowar-Manning, O Laeyendecker, A Young, N Bell-Mandla, J Bwalya, P Bock, S Fidler, H Ayles, R J Hayes
Background: HIV and Herpes simplex virus type-2 (HSV2) are strongly associated, although mechanisms are not fully understood. An HIV prevention trial allowed re-examination of this association at individual and community levels. Methods: HPTN 071 (PopART) evaluates a combination prevention intervention in 21 urban communities in Zambia and South Africa. To measure impact on HIV incidence, a cohort of ~2,000 adults (18-44y) was selected randomly from each community...
April 6, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29659760/coxiella-burnetii-a-hidden-pathogen-in-interstitial-lung-disease
#14
Cléa Melenotte, Jalal-Jean Izaaryene, Carine Gomez, Marion Delord, Elsa Prudent, Hubert Lepidi, Oleg Mediannikov, Marion Lacoste, Felix Djossou, Alexandre Mania, Noelle Bernard, Eric Huchot, Jean-Louis Mège, Fabienne Brégeon, Didier Raoult
We report 7 patients with interstitial lung disease (ILD) on CT-scan reviewing. C. burnetii was diagnosed in situ in one lung biopsy performed. All patients had advanced interstitial lung fibrosis and persistent C. burnetii infection. Q fever may be a cofactor of ILD, especially in endemic areas.
April 6, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29658696/improved-method-for-the-incorporation-of-heme-cofactors-into-recombinant-proteins-using-escherichia-coli-nissle-1917
#15
Kerstin Fiege, Christine Joy Querebillo, Peter Hildebrandt, Nicole Frankenberg-Dinkel
Recombinant production of heme proteins in Escherichia coli is often limited by the availability of heme in the host. Therefore, several methods, including the reconstitution of heme proteins after production but prior to purification or the HPEX system conferring the ability to take up external heme have been developed and used in the past. Here we describe the use of the apathogenic Escherichia coli strain Nissle 1917 (EcN) as a suitable host for the recombinant production of heme proteins. EcN has the advantage over commonly used lab strains that it is able to take up heme from the environment through the heme receptor ChuA...
April 16, 2018: Biochemistry
https://www.readbyqxmd.com/read/29657025/physical-fitness-adiposity-and-diets-as-surrogate-measures-of-bone-health-in-schoolchildren-a-biochemical-and-cross-sectional-survey-analysis
#16
Ahmad H Alghadir, Sami A Gabr, Ashraf A Rizk
This study aimed to investigate the associations between adiposity, muscular fitness (MF), diet, sun exposure, and physical activity profiles as surrogate measures with bone health status in a sample of schoolchildren aged 8-18 yr old. A total of 250 Egyptian schoolchildren aged 8-18 yr were randomly invited to participate in these cross-sectional survey analyses. Calcaneal broadband ultrasound attenuation (c-BUA), bone mineral density (BMD), and bone formation markers (total calcium, serum bone alkaline phosphatase, and osteocalcin) were measured as markers of bone health...
March 21, 2018: Journal of Clinical Densitometry
https://www.readbyqxmd.com/read/29655804/characterization-of-wdr20-a-new-regulator-of-the-erad-machinery
#17
Lin-Gao Ju, Xiang Lin, Dong Yan, Qing-Lan Li, Min Wu, Lian-Yun Li
ERAD is an important process of protein quality control that eliminates misfolded or unassembled proteins from ER. Before undergoing proteasome degradation, the misfolded proteins are dislocated from ER membrane into cytosol, which requires the AAA ATPase p97/VCP and its cofactor, the NPL4-UFD1 dimer. Here, we performed a CRISPR-based screen and identify many candidates for ERAD regulation. We further confirmed four proteins, FBOX2, TRIM6, UFL1 and WDR20, are novel regulators for ERAD. Then the molecular mechanism for WDR20 in ERAD is further characterized...
April 12, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29652607/encapsulation-of-mesenchymal-stem-cells-improves-vascularization-of-alginate-based-scaffolds
#18
Dominik Steiner, Lara Lingens, Laura Fischer, Katrin Köhn, Rainer Detsch, Aldo Roberto Boccaccini, Tobias Fey, Peter Greil, Christian Weis, Justus Beier, Raymund E Horch, Andreas Arkudas
Vascularization of bioartificial tissues can be significantly enhanced by the generation of an arterio-venous loop (AV loop). Besides the surgical vascularization, the choice of the scaffold and the applied cells are indispensable cofactors. The combination of alginate dialdehyde and gelatin (ADA-GEL) and mesenchymal stem cells (MSCs) is a promising approach with regards to biocompatibility, biodegradation as well as de novo tissue formation. In this study we targeted the investigation of the vascularization of ADA-GEL with and in absence of encapsulated MSCs in the AV loop model...
March 20, 2018: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/29651955/increases-in-peripheral-systolic-pressure-levels-and-z-score-associate-gradual-aortic-pressure-increase-and-functional-arterial-impairment-in-children-and-adolescents
#19
Yanina Zocalo, Mariana Marin, Santiago Curcio, Victoria Garcia-Espinosa, Pedro Chiesa, Gustavo Giachetto, Edmundo I Cabrera-Fischer, Daniel Bia
BACKGROUND: Arterial changes associated with children and adolescents high blood pressure (HBP) states would vary depending on the arterial type, arterial indexes considered and/or on blood pressure (BP) levels. AIMS: To determine in children and adolescents: 1) if there is gradual structural-functional arterial impairment associated with gradual peripheral (brachial) systolic BP (pSBP) level or z-score increases, and 2) whether subjects with HBP levels and those with normal BP differ in the profiles of arterial changes associated with pSBP deviations...
April 13, 2018: Current Hypertension Reviews
https://www.readbyqxmd.com/read/29651351/acquired-von-willebrand-disease-associated-with-mantle-cell-lymphoma
#20
Dominique Maas, Britta Laros-van Gorkom, Sanne Gianotten, Marjan Cruijsen, Waander van Heerde, Marten Nijziel
We present a rare case of acquired von Willebrand syndrome (AVWS) caused by a mantle cell lymphoma. A 61-year-old male suffered from recurrent bleeding symptoms since a few months. Initially, physical examination was normal. von Willebrand factor antigen (VWF:Ag) level and factor VIII activity (FVIII:C) were low (0.31 IU/ml and 0.43 IU/ml, resp.). Ristocetin cofactor activity (VWF:RCo) was 0.09 IU/ml, and collagen binding activity (VWF:CB) was 0.10 IU/ml. VWF:RCo/VWF:Ag ratio was 0.29, and RIPA value was normal...
2018: Case Reports in Hematology
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