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Lung sarcoma

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https://www.readbyqxmd.com/read/29469166/spheroid-based-3d-cell-cultures-identify-salinomycin-as-a-promising-drug-for-the-treatment-of-chondrosarcoma
#1
Francesca Perut, Francesca Vittoria Sbrana, Sofia Avnet, Angelo De Milito, Nicola Baldini
Chondrosarcoma (CS) is a cartilage malignancy of adulthood that is treated by surgery alone, since chemotherapy is considered ineffective. Unfortunately, a large proportion of patients with CS develop lung metastases, and several die of the disease. In this study, we compared 3D-spheroid cultures and conventional cell monolayer models in order to identify the best way to select anticancer agents that could be effective for the systemic control of CS. Using SW1353 cells, we developed a three-dimensional (3D) in vitro culture model to mimic in vivo features of CS microenvironment and evaluated the efficacy of different drugs to modulate CS cell proliferation and survival in 2D vs...
February 22, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29465573/synovium-as-a-widespread-pathway-to-the-adjacent-joint-in-undifferentiated-high-grade-pleomorphic-sarcoma-of-the-tibia-a-case-report
#2
Xiaona Li, Zekun Zhang, Mahrukh Latif, Wei Chen, Jianling Cui, Zhigang Peng
RATIONALE: Undifferentiated high-grade pleomorphic sarcoma (UPS), originated from bone, is a rare tumor, accounting for 2% to 5% of all primary maligment bone neoplasms. Skip lesion can be found in undifferentiated high-grade pleomorphic sarcoma of bone (UPS-B). However, the direct invasion across the articular synovium to bone has not been reported previously. PATIENT CONCERNS: We report an unusual case of a 65-year-old man complained of a year history of pain, swelling, and limitation of activity in the left knee joint...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29463229/metastatic-cardiac-tumors-from-clinical-presentation-through-diagnosis-to-treatment
#3
Ivana Burazor, Sarit Aviel-Ronen, Massimo Imazio, Orly Goitein, Marina Perelman, Natalia Shelestovich, Ninoslav Radovanovic, Vladimir Kanjuh, Iris Barshack, Yehuda Adler
BACKGROUND: To evaluate the prevalence of metastatic tumors involving the myocardium and study their presentation in order to increase awareness to their existence. METHODS: Pathological reports from Sheba Medical Center (Israel, January 1, 2010 through December 31, 2015) and medical records from The Institute for Cardiovascular Diseases of Vojvodina, Sremska Kamenica (Serbia, 23 years period) were screened for cases of metastatic cardiac tumors. Medical, radiological and pathological data of identified cases was retrieved and reviewed...
February 20, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29454587/comparison-of-ct-radiogenomic-and-clinical-characteristics-between-egfr-and-kras-mutations-in-lung-adenocarcinomas
#4
J Lv, H Zhang, J Ma, Y Ma, G Gao, Z Song, Y Yang
AIM: To compare computed tomography (CT) radiogenomic and clinical characteristics between patients with epidermal growth factor receptor (EGFR) and Kirsten rat sarcoma viral oncogene (KRAS) mutations in lung adenocarcinomas. MATERIALS AND METHODS: This study was a retrospective analysis of patients with histopathologically confirmed lung adenocarcinoma, who had complete clinical and imaging data, and were tested for EGFR and KRAS mutations. Of the 313 included patients, 116 had effective EGFR mutations (EGFR group), 31 had KRAS mutations (KRAS group), and 166 had no EGFR or KRAS mutations (control group)...
February 14, 2018: Clinical Radiology
https://www.readbyqxmd.com/read/29440819/intravenous-lignocaine-infusion-for-intractable-pain-in-ewing-s-sarcoma
#5
Nivedita Page
A 23-year-old female presented to our palliative care center with Ewing's sarcoma of the humerus with lung metastases. Pain in her arm was unrelieved by nonsteroidal anti-inflammatory drugs, neuropathic medication as well as morphine. She could not tolerate any further increase in opioid dose but was so distraught due to the pain that she wanted to die. An intravenous lignocaine infusion in a dose of 2 mg/kg was given over an hour for three successive days. This successfully relieved her pain after which she was settled with her original medication...
January 2018: Indian Journal of Palliative Care
https://www.readbyqxmd.com/read/29437879/characterizing-the-potency-and-impact-of-carbon-ion-therapy-in-a-primary-mouse-model-of-soft-tissue-sarcoma
#6
Jeremy Michael Brownstein, Amy Jordan Wisdom, Katherine D Castle, Yvonne M Mowery, Peter M Guida, Chang-Lung Lee, Francesco Tommasino, Chiara La Tessa, Emanuele Scifoni, Junheng Gao, Lixia Luo, Lorraine Da Silva Campos, Yan Ma, Nerissa Williams, Sin-Ho Jung, Marco Durante, David G Kirsch
Carbon ion therapy (CIT) offers several potential advantages for treating cancers compared with X-ray and proton radiotherapy including increased biological efficacy and more conformal dosimetry. However, CIT potency has not been characterized in primary tumor animal models. Here, we calculate the relative biological effectiveness (RBE) of carbon ions compared to X-rays in an autochthonous mouse model of soft tissue sarcoma. We used Cre/loxP technology to generate primary sarcomas in KrasLSL-G12D/+; p53fl/fl mice...
February 7, 2018: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/29420353/clusterin-in-neuroendocrine-epithelial-neoplasms-absence-of-expression-in-a-well-differentiated-tumor-suggests-a-jejunoileal-origin
#7
Thomas W Czeczok, Kristen M Stashek, Jessica E Maxwell, Thomas M O'Dorisio, James R Howe, Jason L Hornick, Andrew M Bellizzi
Clusterin, a widely expressed, tissue-specific glycoprotein, is a diagnostic marker of several tumor types, including anaplastic large cell lymphoma, follicular dendritic cell sarcoma, and tenosynovial giant cell tumor. A recent study has suggested it is highly expressed by well-differentiated neuroendocrine tumors (NET) arising at most anatomic sites, with the exception of jejunoileal tumors, and that it is similarly not expressed by poorly differentiated neuroendocrine carcinomas (NEC). We sought to validate this result in a large cohort of NETs and NECs...
February 2018: Applied Immunohistochemistry & Molecular Morphology: AIMM
https://www.readbyqxmd.com/read/29409495/pd-1-axis-expression-in-musculoskeletal-tumors-and-antitumor-effect-of-nivolumab-in-osteosarcoma-model-of-humanized-mouse
#8
Bingxin Zheng, Tingting Ren, Yi Huang, Kunkun Sun, Shidong Wang, Xing Bao, Kuisheng Liu, Wei Guo
BACKGROUND: Immune checkpoint inhibitors have led to a breakthrough in solid tumor immunotherapy, but related studies on musculoskeletal tumors are few, especially for PD-L2. METHODS: We examined expression of three molecular effectors of the PD-1 axis in 234 patients with musculoskeletal tumors, including osteosarcoma, chondrosarcoma, synovial sarcoma, and giant cell tumor. Survival analyses and potential mechanisms were investigated in osteosarcoma per the Gene Expression Omnibus (GEO) and immunohistochemistry analyses...
February 6, 2018: Journal of Hematology & Oncology
https://www.readbyqxmd.com/read/29409129/successful-management-of-a-rare-type-of-complex-myxofibrosarcoma-which-affected-right-lung-and-invading-into-the-left-atrium-under-the-guidance-of-multimode-image
#9
Heng Zhang, Da Zhu, Li Dong
Myxofibrosarcoma is a rare type of highly malignant sarcoma which easily occur lung metastasis. We report a rare metastatic myxofibrosarcoma which generated from the upper and middle lobe of the lung, invading the right superior pulmonary vein, extending to the left atrium. A single imaging examination may lead to misdiagnosis, so the combination of computed tomography imaging, magnetic resonance imaging, as well as positron emission tomographic scan are necessary for perioperative diagnosis and surgical planning...
February 2018: Echocardiography
https://www.readbyqxmd.com/read/29404187/a-case-report-of-secondary-simultaneous-bilateral-pneumothorax-due-to-pazopanib-treatment
#10
Burçin Çelik, Zeynep Pelin Sürücü, Volkan Yılmaz, Hale Kefeli Çelik
Secondary spontaneous pneumothorax almost always develops secondary to an underlying lung disease. A pneumothorax secondary to a malignancy is very rare, and is observed most frequently in soft tissue sarcomas. Pazopanib, a tyrosine kinase inhibitor, is used in metastatic soft tissue sarcomas treatment. The rate of pneumothorax that is caused by pazopanib is about 14% in the literature. The patient being presented in this article underwent surgery for soft tissue sarcoma, postoperatively received pazopanib (Votrient® 400 mg, oral, Glaxo Group Ltd, Brentford, UK) treatment due to widespread bilateral lung metastases, and developed synchronous spontaneous pneumothorax...
January 2018: Turkish Thoracic Journal
https://www.readbyqxmd.com/read/29404161/primary-pulmonary-malignant-fibrous-histiocytoma
#11
Tuğba Coşgun, Yelda Tezel, Mustafa Akyıl, İlker Kolbaş, Ayçım Şen, Çağatay Tezel
Malignant fibrous histiocytoma (MFH) cases are classified within the group of nonclassified sarcomas. The etiopathogenesis is unclear; however, MFH commonly develops in scar tissue and in areas exposed to radiation. MFH is the most common soft tissue sarcoma in adults and may be borne in the lungs, chest wall, mediastinum, or other tissues. Primary MFH of the lung constitutes less than 0.2% of all pulmonary neoplasms; thus, an optimal treatment strategy has not yet been elucidated. We aimed to report a case of MFH of the lung with subsequent treatment administration...
April 2017: Turkish Thoracic Journal
https://www.readbyqxmd.com/read/29400366/correlation-between-contrast-enhanced-ultrasound-and-microvessel-density-via-cd31-and-cd34-in-a-rabbit-vx2-lung-peripheral-tumor-model
#12
Jin Xing, Wen He, Yi-Wen Ding, Yang Li, Yan-Dong Li
AIM: To evaluate the tumor angiogenesis in lung peripheral VX2 tumor model by contrast-enhanced ultrasound (CEUS) and to determine the correlation between CEUS parameters and microvessel density (MVD) calculated via CD31 and CD34 expression. MATERIAL AND METHODS: VX2 pulmonary tumors were created in eight Japanese white rabbits by implanting a VX2 sarcoma into the lower portion of the right lung through ultrasound guidance. Tumors were allowed to grow for 14-21 days to achieve a diameter of 7-15 mm, and were examined by CEUS using a SonoVue contrast agent...
February 4, 2018: Medical Ultrasonography
https://www.readbyqxmd.com/read/29398759/tubercular-mycobacterial-spindle-cell-pseudotumour-a-case-report
#13
Deba Prasad Dhibar, Kamal Kant Sahu, Surjit Singh, Amanjit Bal, Abhijit Chougale, Varun Dhir
Pseudotumour is a benign inflammatory lesion. Mycobacterial spindle cell pseudotumour (MSP) is a rare pseudotumour. It is a benign proliferation of spindle-shaped histiocytes containing acid-fast mycobacterium, commonly reported in immunocompromised patients. MSP is usually associated with mycobacterium avium complex (MAC). Here, we present the case of a 38-year-old gentleman with acquired immune deficiency syndrome (AIDS) who presented with low-grade fever for 1-month duration. Clinically, he had generalised lymphadenopathy...
January 2018: Iranian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29391717/hemangioendothelioma-of-palate-a-case-report-with-review-of-literature
#14
R Heera, Latha Mary Cherian, Rupali Lav, V Ravikumar
Hemangioendothelioma commonly occurs in the superficial or deep soft tissue of the extremities, lungs, liver, bone and lymph nodes, with oral cavity being a rare location. It is usually benign but can show variable grades of malignancy. According to the histological presentation, hemangioendothelioma has been classified as epithelioid, Kaposiform, hobnail (Dabska-Retiform), epithelioid sarcoma like and composite. We present a case of ulcerated swelling of palate clinically diagnosed as pyogenic granuloma which presented a diagnostically challenging histological picture...
September 2017: Journal of Oral and Maxillofacial Pathology: JOMFP
https://www.readbyqxmd.com/read/29390485/antiangiogenic-therapy-for-primitive-neuroectodermal-tumor-with-thalidomide-a-case-report-and-review-of-literature
#15
REVIEW
Qing Li, Yong Liu, Yang Yu
RATIONALE: Peripheral primitive neuroectodermal tumor (PNET) is a kind of small round cell tumor derived from primitive neuroectodermal tumor. PATIENT CONCERNS: PNET is a highly malignant tumor that is subordinated to Ewing sarcoma. It occurs predominantly in soft tissue and bone and rarely in the bronchi and lung. Traditional surgery, radiotherapy, and chemotherapy are used for the treatment of PNET, but are usually ineffective. DIAGNOSES: There was a rare case of a 17 year-old man diagnoses with primary pulmonary PNET...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29390436/endostar-combined-with-chemotherapy-in-a-pediatric-osteosarcoma-with-pulmonary-metastasis-and-malignant-pleural-effusion-a-case-report
#16
Sujing Jiang, Guannan Wang, Ying Dong
RATIONALE: Angiogenesis is a key factor for tumor growth and metastasis both in cancer and sarcoma. Endostar, a novel safe and well-tolerated recombinant human endostatin, can suppress the expression of VEGF and the activation of ERK, MAPK, and AKT, and then inhibit tumor progression. PATIENT CONCERNS: A pediatric osteosarcoma with pulmonary metastasis and malignant pleural effusion. DIAGNOSES: Osteosarcoma with pulmonary metastasis and malignant pleural effusion...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29387511/extraosseous-ewing-s-sarcoma-of-the-pancreas-an-uncommon-but-treatable-disease
#17
Muhammad W Saif, Kristin Kaley
Extraosseous Ewing's sarcoma/primitive neuroectodermal tumor (ES/PNET) is a rare but aggressive and malignant tumor, and has been reported in various sites such as the lungs, biliary tract, kidney, prostate, stomach, esophagus, oral cavity, salivary glands, urinary bladder, uterus, cervix, gonads, and vagina. However, the pancreas is considered to be an extremely uncommon site and only a handful of cases have been published to date. We present here another case of a pancreatic ES/PNET. Our case intensifies the importance to recognize this rare type of tumor in the pancreas as there is a broad spectrum of tumors with a similar morphology that includes sheets of small, round blue cells...
November 26, 2017: Curēus
https://www.readbyqxmd.com/read/29383713/prognostic-factors-for-soft-tissue-sarcoma-patients-with-lung-metastases-only-who-are-receiving-first-line-chemotherapy-an-exploratory-retrospective-analysis-of-the-european-organization-for-research-and-treatment-of-cancer-soft-tissue-and-bone-sarcoma-group
#18
Lars H Lindner, Saskia Litière, Stefan Sleijfer, Charlotte Benson, Antoine Italiano, Bernd Kasper, Christina Messiou, Hans Gelderblom, Eva Wardelmann, Axel Le Cesne, Jean-Yves Blay, Sandrine Marreaud, Nadia Hindi, Ingrid M E Desar, Alessandro Gronchi, Winette T A van der Graaf
The prognosis of adult soft tissue sarcoma (STS) patients with metastases is generally poor. As little is known about the impact of the involvement of different metastatic sites and the extent of pulmonary lesions on the outcome for patients receiving first-line chemotherapy, we aimed to establish prognostic factors for STS patients with lung metastases only. A retrospective, exploratory analysis was performed on 2913 metastatic STS patients who received first-line chemotherapy. Detailed information from 580 patients who had lung metastases only, was used for prognostic factor analysis...
January 31, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29375717/diagnosis-clinicopathological-characteristics-and-prognosis-of-pulmonary-mucinous-adenocarcinoma
#19
Fei Sun, Pengcheng Wang, Yiming Zheng, Weiguang Jia, Fuxing Liu, Wei Xiao, Jingjing Bao, Song Wang, Kaijin Lu
Primary pulmonary mucinous adenocarcinoma (PPMA) is an uncommon subtype of lung adenocarcinoma. The present study attempted to clarify the diagnosis, clinicopathological characteristics, and pathologic significance of epithelial growth factor receptor (EGFR) and Kirsten rat sarcoma viral oncogene (KRAS) mutations and the prognosis of PPMA. A total of 29 patients with PPMA from among 1,469 surgically resected patients with lung adenocarcinoma were enrolled. All of the tumours expressed CK7 and 5 cases exhibited co-expression with CK20...
January 2018: Oncology Letters
https://www.readbyqxmd.com/read/29362339/-a-case-of-stage-iv-metaplastic-breast-cancer-in-which-primary-tumor-was-removed-after-treatment-with-anti-her2-systemic-therapy
#20
Chiyomi Egawa, Junichi Inatome, Takuya Sakamoto, Atsushi Naito, Kohei Murakami, Yoshiteru Katsura, Yoshiaki Ohmura, Yoshinori Kagawa, Atsushi Takeno, Yutaka Takeda, Kohei Murata, Yuichi Takatsuka, Takayoshi Goto, Teruaki Nagano
The patient was a 58-year-oldpostmenopausal woman. Vacuum assistedbiopsy of the left breast tumor revealedinvasive ductal carcinoma. Immunohistochemical examination was negative for estrogen receptor(ER), negative for progesterone receptor(PgR), andshowedan HER2 score of 3+. FDG-PET/CT revealedmultiple metastases to the left supracravicular and axillary lymph nodes and lungs. She was diagnosed with HER2-positive T3N3M1, Stage IV breast cancer. A 2-year regimen of chemotherapy with trastuzumab andvinorelbine achieveda complete response with regardto the metastatic sites; however, the size of the primary tumor increasedd espite the chemotherapy, andsurgical resection of the left breast with axillary lymph node dissection was performed for local control...
January 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
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