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https://www.readbyqxmd.com/read/27936427/an-observed-rise-in-%C3%AE-hydroxybutyrate-associated-deaths-in-london-evidence-to-suggest-a-possible-link-with-concomitant-rise-in-chemsex
#1
Joanna Hockenhull, Kevin G Murphy, Sue Paterson
BACKGROUND: Gamma-hydroxybutyrate (GHB) is the drug most linked to acute harm out of those used in chemsex, the incidence of which is reported to be increasing. However, there have been few systematic studies of the harms associated with GHB use. We investigated GHB-associated deaths from London coroners' jurisdictions between 2011 and 2015. METHODS: Blood and urine samples were collected by pathologists and submitted for toxicological analysis at the request of coroners...
December 2, 2016: Forensic Science International
https://www.readbyqxmd.com/read/27925557/-don-t-be-afraid-of-failure
#2
(no author information available yet)
Venetia Wynter-Blyth has worked in oncology for 15 years. She spent 12 years as an upper gastrointestinal (GI) clinical nurse specialist before taking up her current post as Macmillan nurse consultant in upper GI cancers at Imperial College Healthcare NHS Trust in London. She was named RCN Nurse of the Year 2016 for creating PREPARE, a holistic 'prehabilitation' self-management programme for people with cancer who require surgery.
December 7, 2016: Nursing Standard
https://www.readbyqxmd.com/read/27923309/-make-your-opportunities
#3
Layla Haidrani
What is your job? I am a clinical research nurse for neurosurgery, emergency and trauma at Imperial College Healthcare NHS Trust, London. My role involves supporting research in neurosurgery, emergency and trauma care. I offer guidance at all stages of the research process, from project conception to output.
December 7, 2016: Emergency Nurse: the Journal of the RCN Accident and Emergency Nursing Association
https://www.readbyqxmd.com/read/27861025/vaccines-in-pregnancy-matimms
#4
(no author information available yet)
This app was developed by researchers and clinicians at Imperial College London and Imperial College Healthcare NHS Trust after concern about the low uptake of vaccines among pregnant women.
November 2, 2016: Nursing Standard
https://www.readbyqxmd.com/read/27805046/natural-resistance-to-meningococcal-disease-related-to-cfh-loci-meta-analysis-of-genome-wide-association-studies
#5
Federico Martinón-Torres, Eileen Png, Chiea Chuen Khor, Sonia Davila, Victoria J Wright, Kar Seng Sim, Ana Vega, Laura Fachal, David Inwald, Simon Nadel, Enitan D Carrol, Nazareth Martinón-Torres, Sonia Marcos Alonso, Angel Carracedo, Elvira Morteruel, Julio López-Bayón, Andrés Concha Torre, Cristina Calvo Monge, Pilar Azcón González de Aguilar, Elisabeth Esteban Torné, María Del Carmen Martínez-Padilla, José María Martinón-Sánchez, Michael Levin, Martin L Hibberd, Antonio Salas
Meningococcal disease (MD) remains an important infectious cause of life threatening infection in both industrialized and resource poor countries. Genetic factors influence both occurrence and severity of presentation, but the genes responsible are largely unknown. We performed a genome-wide association study (GWAS) examining 5,440,063 SNPs in 422 Spanish MD patients and 910 controls. We then performed a meta-analysis of the Spanish GWAS with GWAS data from the United Kingdom (combined cohorts: 897 cases and 5,613 controls; 4,898,259 SNPs)...
November 2, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27703670/opportunities-and-considerations-for-visualising-neuroimaging-data-on-very-large-displays
#6
Matthew B Wall, David Birch, May Y Yong
Neuroimaging experiments can generate impressive volumes of data and many images of the results. This is particularly true of multi-modal imaging studies that use more than one imaging technique, or when imaging is combined with other assessments. A challenge for these studies is appropriate visualisation of results in order to drive insights and guide accurate interpretations. Next-generation visualisation technology therefore has much to offer the neuroimaging community. One example is the Imperial College London Data Observatory; a high-resolution (132 megapixel) arrangement of 64 monitors, arranged in a 313 degree arc, with a 6 metre diameter, powered by 32 rendering nodes...
2016: F1000Research
https://www.readbyqxmd.com/read/27484970/new-patient-reported-experience-measure-for-children-with-allergic-disease-development-validation-and-results-from-integrated-care
#7
C Gore, R Griffin, T Rothenberg, A Tallett, B Hopwood, S Sizmur, C O'Keeffe, J O Warner
OBJECTIVES: To develop and validate a new allergy-specific patient-reported experience measure (PREM) for children and their parents, and to collect feedback in an integrated care setting. DESIGN: Two allergy-specific PREMs were produced using focus groups, cognitive testing, two prospective validation studies (collaboration: Royal College of Paediatrics and Child Health, Picker Institute Europe, Imperial College/London): 'Your Allergy Care', for children aged 8-16 years; 'Your Child's Allergy Care', for parents of children aged 0-7 years...
October 2016: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/27468335/impact-of-clinical-and-procedural-factors-upon-c-reactive-protein-dynamics-following-transcatheter-aortic-valve-implantation
#8
Neil Ruparelia, Vasileios F Panoulas, Angela Frame, Ben Ariff, Nilesh Sutaria, Michael Fertleman, Jonathan Cousins, Jon Anderson, Colin Bicknell, Andrew Chukwuemeka, Sayan Sen, Iqbal S Malik, Antonio Colombo, Ghada W Mikhail
AIM: To determine the effect of procedural and clinical factors upon C reactive protein (CRP) dynamics following transcatheter aortic valve implantation (TAVI). METHODS: Two hundred and eight consecutive patients that underwent transfemoral TAVI at two hospitals (Imperial, College Healthcare NHS Trust, Hammersmith Hospital, London, United Kingdom and San Raffaele Scientific Institute, Milan, Italy) were included. Daily venous plasma CRP levels were measured for up to 7 d following the procedure (or up to discharge)...
July 26, 2016: World Journal of Cardiology
https://www.readbyqxmd.com/read/27458619/cardiopulse-leaders-in-cardiovascular-medicine-of-today-professor-david-wood-imperial-college-london
#9
Mark Nicholls
No abstract text is available yet for this article.
February 7, 2016: European Heart Journal
https://www.readbyqxmd.com/read/27342755/a-virtual-reality-training-curriculum-for-laparoscopic-colorectal-surgery
#10
Laura Beyer-Berjot, Stéphane Berdah, Daniel A Hashimoto, Ara Darzi, Rajesh Aggarwal
OBJECTIVE: Training within a competency-based curriculum (CBC) outside the operating room enhances performance during real basic surgical procedures. This study aimed to design and validate a virtual reality CBC for an advanced laparoscopic procedure: sigmoid colectomy. DESIGN: This was a multicenter randomized study. Novice (surgeons who had performed <5 laparoscopic colorectal resections as primary operator), intermediate (between 10 and 20), and experienced surgeons (>50) were enrolled...
November 2016: Journal of Surgical Education
https://www.readbyqxmd.com/read/27293773/the-impact-of-the-doh-commissioning-for-quality-and-innovation-incentive-on-the-success-of-venous-thromboembolism-risk-assessment-in-hospitalised-patients-a-single-institution-experience-in-a-quality-outcome-improvement-over-a-4-year-cycle
#11
Abdul Shlebak, Polly Sandhu, Vernisha Ali, Garth Jones, Christopher Baker
OBJECTIVES: To i) demonstrate compliance with the Commissioning for Quality and Innovation for venous thromboembolism risk assessment ii) to undertake root cause analysis of Hospital Acquired Thrombosis and to investigate its impact on quality of care. DESIGN: Prospective monitoring of all admissions. SETTING: Imperial College Healthcare Hospitals, London. PARTICIPANTS: All Hospital Provider Spells as defined on the NHS Data Model and Dictionary...
June 2016: JRSM Open
https://www.readbyqxmd.com/read/27284027/the-foundry-the-dna-synthesis-and-construction-foundry-at-imperial-college
#12
REVIEW
Stephen Chambers, Richard Kitney, Paul Freemont
The establishment of a DNA synthesis and construction foundry at Imperial College in London heralds a new chapter in the development of synthetic biology to meet new global challenges. The Foundry employs the latest technology to make the process of engineering biology easier, faster and scalable. The integration of advanced software, automation and analytics allows the rapid design, build and testing of engineered organisms.
June 15, 2016: Biochemical Society Transactions
https://www.readbyqxmd.com/read/27231741/patient-safety-the-next-15-years-part-2
#13
John Tingle
No abstract text is available yet for this article.
May 26, 2016: British Journal of Nursing: BJN
https://www.readbyqxmd.com/read/27190092/leadership-behaviours-and-healthcare-research-performance-prospective-correlational-study
#14
Vanash M Patel, Hutan Ashrafian, Chukwudi Uzoho, Nikolaos Nikiteas, Pietro Panzarasa, Nick Sevdalis, Ara Darzi, Thanos Athanasiou
OBJECTIVES: The aims of the study were to determine whether differences in leadership self-perception/behaviour in healthcare researchers may influence research performance and to evaluate whether certain leadership characteristics are associated with enhanced leadership efficiency in terms of motivation, effectiveness and satisfaction. DESIGN AND PARTICIPANTS: All Faculty of Medicine Professors at Imperial College London (n=215) were sent the Multifactor Leadership Questionnaire (MLQ) Self form as a means of evaluating self-perception of leadership behaviours...
May 16, 2016: Postgraduate Medical Journal
https://www.readbyqxmd.com/read/27187640/reproductive-health-factors-associated-with-risk-of-death-in-women
#15
(no author information available yet)
A better understanding of how reproductive factors influence long-term health could help practitioners develop strategies to improve women's health, say Imperial College London researchers.
November 18, 2015: Nursing Standard
https://www.readbyqxmd.com/read/27180021/multicentre-evaluation-of-multidisciplinary-team-meeting-agreement-on-diagnosis-in-diffuse-parenchymal-lung-disease-a-case-cohort-study
#16
Simon L F Walsh, Athol U Wells, Sujal R Desai, Venerino Poletti, Sara Piciucchi, Alessandra Dubini, Hilario Nunes, Dominique Valeyre, Pierre Y Brillet, Marianne Kambouchner, António Morais, José M Pereira, Conceição Souto Moura, Jan C Grutters, Daniel A van den Heuvel, Hendrik W van Es, Matthijs F van Oosterhout, Cornelis A Seldenrijk, Elisabeth Bendstrup, Finn Rasmussen, Line B Madsen, Bibek Gooptu, Sabine Pomplun, Hiroyuki Taniguchi, Junya Fukuoka, Takeshi Johkoh, Andrew G Nicholson, Charlie Sayer, Lilian Edmunds, Joseph Jacob, Maria A Kokosi, Jeffrey L Myers, Kevin R Flaherty, David M Hansell
BACKGROUND: Diffuse parenchymal lung disease represents a diverse and challenging group of pulmonary disorders. A consistent diagnostic approach to diffuse parenchymal lung disease is crucial if clinical trial data are to be applied to individual patients. We aimed to evaluate inter-multidisciplinary team agreement for the diagnosis of diffuse parenchymal lung disease. METHODS: We did a multicentre evaluation of clinical data of patients who presented to the interstitial lung disease unit of the Royal Brompton and Harefield NHS Foundation Trust (London, UK; host institution) and required multidisciplinary team meeting (MDTM) characterisation between March 1, 2010, and Aug 31, 2010...
July 2016: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/27136247/psychological-issues-associated-with-absolute-uterine-factor-infertility-and-attitudes-of-patients-toward-uterine-transplantation
#17
Srdjan Saso, Alex Clarke, Timothy Bracewell-Milnes, Anja Saso, Maya Al-Memar, Meen-Yau Thum, Joseph Yazbek, Giuseppe Del Priore, Paul Hardiman, Sadaf Ghaem-Maghami, J Richard Smith
CONTEXT: Uterine transplantation (UTx). OBJECTIVE: To explore patients' knowledge of and attitudes toward UTx before and after a short educational intervention via a video and question and answer (Q&A) session. DESIGN: Large, in-depth survey investigating patients' motivations, aims, and beliefs on UTx. SETTING: Imperial College London. PARTICIPANTS: Women diagnosed with absolute uterine factor infertility (AUFI) who were seeking information on UTx and had already volunteered to participate in the study...
March 2016: Progress in Transplantation
https://www.readbyqxmd.com/read/26994000/mentoring-perception-and-academic-performance-an-academic-health-science-centre-survey
#18
Thanos Athanasiou, Vanash Patel, George Garas, Hutan Ashrafian, Kunal Shetty, Nick Sevdalis, Pietro Panzarasa, Ara Darzi, Sotirios Paroutis
PURPOSE: To determine the association between professors' self-perception of mentoring skills and their academic performance. DESIGN: Two hundred and fifteen professors from Imperial College London, the first Academic Health Science Centre (AHSC) in the UK, were surveyed. The instrument adopted was the Mentorship Skills Self-Assessment Survey. Statement scores were aggregated to provide a score for each shared core, mentor-specific and mentee-specific skill. Univariate and multivariate regression analyses were used to evaluate their relationship with quantitative measures of academic performance (publications, citations and h-index)...
October 2016: Postgraduate Medical Journal
https://www.readbyqxmd.com/read/26981255/problem-based-learning-case-writing-by-students-based-on-early-years-clinical-attachments-a-focus-group-evaluation
#19
Yewande Idowu, Elizabeth Muir, Graham Easton
OBJECTIVES: To evaluate the perception of medical students of the new approach to problem-based learning which involves students writing their own problem-based learning cases based on their recent clinical attachment, and team assessment. DESIGN: Focus group interviews with students using purposive sampling. Transcripts of the audio recordings were analysed using thematic analysis. SETTING: Imperial College School of Medicine, London. PARTICIPANTS: Medical students in the second year of the MBBS course, who attended the problem-based learning case writing session...
March 2016: JRSM Open
https://www.readbyqxmd.com/read/26960323/a-breakthrough-in-enzyme-technology-to-fight-penicillin-resistance-industrial-application-of-penicillin-amidase
#20
REVIEW
Klaus Buchholz
Enzymatic penicillin hydrolysis by penicillin amidase (also penicillin acylase, PA) represents a Landmark: the first industrially and economically highly important process using an immobilized biocatalyst. Resistance of infective bacteria to antibiotics had become a major topic of research and industrial activities. Solutions to this problem, the antibiotics resistance of infective microorganisms, required the search for new antibiotics, but also the development of derivatives, notably penicillin derivatives, that overcame resistance...
May 2016: Applied Microbiology and Biotechnology
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