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Gynecology Emergency

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https://www.readbyqxmd.com/read/27910067/next-generation-sequencing
#1
Matthieu Le Gallo, Fred Lozy, Daphne W Bell
Endometrial cancers are the most frequently diagnosed gynecological malignancy and were expected to be the seventh leading cause of cancer death among American women in 2015. The majority of endometrial cancers are of serous or endometrioid histology. Most human tumors, including endometrial tumors, are driven by the acquisition of pathogenic mutations in cancer genes. Thus, the identification of somatic mutations within tumor genomes is an entry point toward cancer gene discovery. However, efforts to pinpoint somatic mutations in human cancers have, until recently, relied on high-throughput sequencing of single genes or gene families using Sanger sequencing...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/27909907/obesity-and-ovarian-cancer
#2
Shelley S Tworoger, Tianyi Huang
Ovarian cancer is the most fatal gynecologic cancer and is an important source of cancer-related mortality, particularly in developed countries. Despite substantial research examining adiposity (primarily adult body mass index [BMI]), the overall evidence suggests only a weak positive association between adiposity and risk of ovarian cancer, with stronger associations observed for population-based case-control studies compared to prospective studies. Ovarian cancer is not one disease and emerging data suggest that higher BMI may only be associated with risk of certain histologic subtypes, including low-grade serous and invasive mucinous tumors...
2016: Recent Results in Cancer Research
https://www.readbyqxmd.com/read/27894428/pediatric-ovarian-torsion
#3
REVIEW
Krista J Childress, Jennifer E Dietrich
Adnexal torsion is the fifth most common gynecologic emergency. The vague clinical presentation and variable imaging findings make the diagnosis difficult. If suspicion for adnexal torsion is high enough based on clinical symptoms and imaging findings, prompt intervention should include conservative management with laparoscopic adnexal detorsion and ovarian preservation even in the event of a necrotic-appearing ovary because studies persistently show follicular development and ovarian function after a short time period and no increased patient morbidity...
February 2017: Surgical Clinics of North America
https://www.readbyqxmd.com/read/27884207/potential-contribution-of-the-uterine-microbiome-in-the-development-of-endometrial-cancer
#4
Marina R S Walther-António, Jun Chen, Francesco Multinu, Alexis Hokenstad, Tammy J Distad, E Heidi Cheek, Gary L Keeney, Douglas J Creedon, Heidi Nelson, Andrea Mariani, Nicholas Chia
BACKGROUND: Endometrial cancer studies have led to a number of well-defined but mechanistically unconnected genetic and environmental risk factors. One of the emerging modulators between environmental triggers and genetic expression is the microbiome. We set out to inquire about the composition of the uterine microbiome and its putative role in endometrial cancer. METHODS: We undertook a study of the microbiome in samples taken from different locations along the female reproductive tract in patients with endometrial cancer (n = 17), patients with endometrial hyperplasia (endometrial cancer precursor, n = 4), and patients afflicted with benign uterine conditions (n = 10)...
November 25, 2016: Genome Medicine
https://www.readbyqxmd.com/read/27868456/emergency-peripartum-hysterectomy-single-center-ten-year-experience
#5
Hüseyin Çağlayan Özcan, Mete Gurol Uğur, Özcan Balat, Neslihan Bayramoğlu Tepe, Seyhun Sucu
PURPOSE: The purpose of our study is to determine the incidence, risk factors, indications, outcomes, and complications of emergency peripartum hysterectomy (EPH) performed in a university hospital. METHODS: This retrospective study includes 54 cases of EPH performed at the department of obstetrics and gynecology of Gaziantep University Hospital between the years 2005-2015. We included all hysterectomy cases during the first 24 h after delivery beyond 20 weeks of gestation...
December 1, 2016: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/27865939/c-reactive-protein-response-is-higher-in-early-than-in-late-ovarian-hyperstimulation-syndrome
#6
Kati V M Korhonen, Hanna M Savolainen-Peltonen, Tomi S Mikkola, Aila E Tiitinen, Leila S Unkila-Kallio
OBJECTIVES: Many in vitro fertilization (IVF) complications are inflammatory by nature, some of which are even life-threatening. We evaluated the response of C-reactive protein (CRP) in IVF complications, especially in early and late ovarian hyperstimulation syndrome (OHSS), to support clinical decision making in gynecological emergency policlinics. STUDY DESIGN: In a prospective two-year study at Helsinki University Hospital, Finland, we recruited patients with IVF complications including moderate or severe OHSS (n=47 patients: 36 early and 14 late OHSS cases), or other IVF complications (n=13)...
October 31, 2016: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/27863981/physician-s-perceived-roles-as-well-as-barriers-toward-caring-for-women-sex-assault-survivors
#7
Priyanka Amin, Raquel Buranosky, Judy C Chang
BACKGROUND: Sexual assault (SA) affects about 40% of women in the United States and has many mental and physical health sequelae. Physicians often do not address SA with patients, although SA survivors describe a desire to talk to physicians to obtain additional help. Little information exists on how providers perceive their roles regarding caring for women SA survivors and what barriers they face in providing this care. METHODS: We performed a qualitative study using semistructured one-on-one interviews with 16 faculty physicians from five specialties: obstetrics and gynecology (n = 4), internal medicine (n = 4), family medicine (n = 1), emergency medicine (n = 3), and psychiatry (n = 4)...
November 15, 2016: Women's Health Issues: Official Publication of the Jacobs Institute of Women's Health
https://www.readbyqxmd.com/read/27856295/street-smarts-and-a-scalpel-emotional-intelligence-in-surgical-education
#8
Mary Kate Erdman, Alisha Bonaroti, Gina Provenzano, Rachel Appelbaum, Marybeth Browne
OBJECTIVE: To evaluate trends of emotional intelligence (EI) in surgical education and to compare the incorporation of EI in surgical education to other fields of graduate medical education. DESIGN: A MEDLINE search was performed for publications containing both "surgery" and "emotional intelligence" with at least one term present in the title. Articles were included if the authors deemed EI in surgical education to be a significant focus. A separate series of MEDLINE searches were performed with the phrase "emotional intelligence" in any field and either "surg*," "internal medicine," "pediatric," "neurology," "obstetric," "gynecology," "OBGYN," "emergency," or "psychiat*" in the title...
November 14, 2016: Journal of Surgical Education
https://www.readbyqxmd.com/read/27853733/pedagogic-approach-in-the-surgical-learning-the-first-period-of-assistant-surgeon-may-improve-the-learning-curve-for-laparoscopic-robotic-assisted-hysterectomy
#9
Angeline Favre, Stephanie Huberlant, Marie Carbonnel, Julie Goetgheluck, Aurelie Revaux, Jean Marc Ayoubi
BACKGROUND: Hysterectomy is the most frequent surgery done with robotic assistance in the world and has been widely studied since its emergence. The surgical outcomes of the robotic hysterectomy are similar to those obtained with other minimally invasive hysterectomy techniques (laparoscopic and vaginal) and appear as a promising surgical technique in gynecology surgery. The aim of this study was to observe the learning curve of robot-assisted hysterectomy in a French surgical center, and was to evaluate the impact of the surgical mentoring...
2016: Frontiers in Surgery
https://www.readbyqxmd.com/read/27832075/is-a-self-assessed-questionnaire-useful-for-the-diagnosis-of-ectopic-pregnancy-in-hospitalized-patients
#10
Camille Mimoun, Arnaud Fauconnier, Catalina Varas, Cyrille Huchon
BACKGROUND: Delayed diagnosis of ectopic pregnancy (EP) is responsible for maternal morbidity and mortality. Our objective was to develop and validate decision rules for the diagnosis of EP, in patients in their first trimester of pregnancy with symptoms, based solely on a self-assessment questionnaire. METHODS: From September 2006 to March 2008, 574 patients, who have consulted for acute pelvic pain at the gynecologic emergency department (ED) of five hospitals, completed a Self-Assessment Questionnaire for Gynecological Emergencies (SAQ-GE)...
2016: PloS One
https://www.readbyqxmd.com/read/27829461/gender-difference-in-preference-of-specialty-as-a-career-choice-among-japanese-medical-students
#11
Ryuichi Kawamoto, Daisuke Ninomiya, Yoshihisa Kasai, Tomo Kusunoki, Nobuyuki Ohtsuka, Teru Kumagi, Masanori Abe
BACKGROUND: In Japan, the absolute deficiency of doctors and maldistribution of doctors by specialty is a significant problem in the Japanese health care system. The purpose of this study was to investigate the factors contributing to specialty preference in career choice among Japanese medical students. METHODS: A total of 368 medical students completed the survey giving an 88.2 % response rate. The subjects comprised 141 women aged 21 ± 3 (range, 18-34) years and 227 men aged 22 ± 4 (range, 18-44) years...
November 10, 2016: BMC Medical Education
https://www.readbyqxmd.com/read/27826776/development-of-a-novel-simulation-model-for-assessment-of-laparoscopic-camera-navigation
#12
Melissa W Brackmann, Pamela Andreatta, Karen McLean, R Kevin Reynolds
BACKGROUND: Laparoscopic camera navigation is vital to laparoscopic surgery, yet often falls to the most junior member of the surgical team who has limited laparoscopic operating experience. Previously published reports on simulation models fail to address qualitative scoring of movement, method of communication and correct physician location with respect to patient position. The purpose of this study was to develop and evaluate a novel laparoscopic camera navigation simulation model that addresses these deficiencies...
November 8, 2016: Surgical Endoscopy
https://www.readbyqxmd.com/read/27824773/prevalence-indications-risk-indicators-and-outcomes-of-emergency-peripartum-hysterectomy-worldwide-a-systematic-review-and-meta-analysis
#13
Thomas van den Akker, Carolien Brobbel, Olaf M Dekkers, Kitty W M Bloemenkamp
OBJECTIVE: To compare prevalence, indications, risk indicators, and outcomes of emergency peripartum hysterectomy across income settings. DATA SOURCES: PubMed, MEDLINE, EMBASE, ClinicalTrials.gov, and Cochrane Library databases up to March 30, 2015. METHODS OF STUDY SELECTION: Studies including emergency peripartum hysterectomies performed within 6 weeks postpartum. Not eligible were comments, case reports, elective hysterectomies for associated gynecologic conditions, studies with fewer than 10 inclusions, and those reporting only percentages published in languages other than English or before 1980...
December 2016: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27810073/the-emerging-role-of-long-non-coding-rnas-in-endometrial-cancer
#14
REVIEW
Konii Takenaka, Bei Jun Chen, Susan C Modesitt, Frances L Byrne, Kyle L Hoehn, Michael Janitz
The human genome is pervasively transcribed and approximately 98% of the genome is non-coding. Long non-coding RNAs (lncRNAs) are a heterogeneous group of RNA transcripts that are >200 nucleotides in length with minimal to no protein-coding potential. Similar to proteins, lncRNAs have important biological functions in both normal cells and disease states including many types of cancer. This review summarizes recent advances in our understanding of lncRNAs in cancer biology and highlights the potential for lncRNA as diagnostic biomarkers and therapeutics...
October 2016: Cancer Genetics
https://www.readbyqxmd.com/read/27807064/mechanisms-and-targets-involved-in-dissemination-of-ovarian-cancer
#15
REVIEW
Ulrich H Weidle, Fabian Birzele, Gwendlyn Kollmorgen, Rüdiger Rueger
Ovarian carcinoma is associated with the highest death rate of all gynecological tumors. On one hand, its aggressiveness is based on the rapid dissemination of ovarian cancer cells to the peritoneum, the omentum, and organs located in the peritoneal cavity, and on the other hand, on the rapid development of resistance to chemotherapeutic agents. In this review, we focus on the metastatic process of ovarian cancer, which involves dissemination of, homing to and growth of tumor cells in distant organs, and describe promising molecular targets for possible therapeutic intervention...
November 2016: Cancer Genomics & Proteomics
https://www.readbyqxmd.com/read/27803848/the-100-most-cited-articles-in-ectopic-pregnancy-a-bibliometric-analysis
#16
Xue-Lian Chen, Zi-Ru Chen, Zhen-Lan Cao, Ke Han, Ya-Wen Tong, Xiao-Hui Xiang, Chun-Xiu Hu
Ectopic pregnancy (EP) remains a major gynecological emergency and is a cause of morbidity or even mortality in women. As a consequence, top citation analysis of EP research in database of the Science Citation Index Expanded is needed to assess the publication trends of leading countries/territories and institutes as well as the research hotspots of EP. A total of 4881 articles relevant to EP were retrieved in the database of the Science Citation Index Expanded from 1965 to present, in which the 100 top-cited articles were selected for further analysis...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27801734/pd-l1-expression-in-carcinosarcomas-of-the-gynecologic-tract-a-potentially-actionable-biomarker
#17
Andre Pinto, Nicholas Mackrides, Mehrdad Nadji
BACKGROUND: Carcinosarcomas of the gynecologic tract, also known as malignant mixed Müllerian tumors, are aggressive neoplasms with a high recurrence rate and poor prognosis. Despite advances in adjuvant therapies in recent years, the prognosis of these tumors has not improved. In fact, there are currently no consensus guidelines for the treatment of these neoplasms and the search for targetable biomarkers has not been successful so far. Programmed death-ligand 1 (PD-L1) has emerged as a potential target for therapeutics in a number of malignant tumors, including melanoma, lung, and colorectal cancer...
October 31, 2016: Applied Immunohistochemistry & Molecular Morphology: AIMM
https://www.readbyqxmd.com/read/27794568/bevacizumab-in-ovarian-cancer-state-of-the-art-and-unanswered-questions
#18
Angela Musella, Laura Vertechy, Alessia Romito, Claudia Marchetti, Andrea Giannini, Valentina Sciuga, Carlotta Bracchi, Federica Tomao, Violante Di Donato, Francesca De Felice, Marco Monti, Ludovico Muzii, Pierluigi Benedetti Panici
Ovarian cancer is a most lethal gynecologic tumor. The mainstay treatment is cytoreductive surgery followed by platinum-based chemotherapy. However, a high percentage of patients recur, thus needing multiple treatments with a frequently poor prognosis. In the last two decades, research has focused on the potential of target therapies to improve the survival of patients affected by ovarian cancer. Bevacizumab is one of the most studied target therapies, and it is approved for first- and second-line treatment of advanced epithelial ovarian, fallopian tube, and primary peritoneal tumors...
October 29, 2016: Chemotherapy
https://www.readbyqxmd.com/read/27760587/truncated-bid-overexpression-induced-by-recombinant-adenovirus-cre-loxp-system-suppresses-the-tumorigenic-potential-of-cd133-ovarian-cancer-stem-cells
#19
Qifang Long, Weipei Zhu, Jundong Zhou, Jinchang Wu, Weixian Lu, Cui Zheng, Dongmei Zhou, Ling Yu, Ru Yang
Ovarian cancer is one of the most lethal malignant gynecologic tumors with a high relapse rate worldwide. Cancer stem cells (CSC) have been identified in ovarian cancer and other malignant tumors as a small population of cells that are capable of self-renew and multi-differentiation. CD133 positive (CD133(+)) ovarian cancer stem cells have been reported to be more tumorigenic and more resistant to chemotherapeutic treatment. Thus, CD133 has emerged as one of the most promising therapeutic markers for ovarian cancer treatment...
October 18, 2016: Oncology Research
https://www.readbyqxmd.com/read/27741957/where-teachers-are-few-documenting-available-faculty-in-five-tanzanian-medical-schools
#20
Charles A Mkony, Ephata E Kaaya, Alex J Goodell, Sarah B Macfarlane
BACKGROUND: Faced with one of the lowest physician-to-population ratios in the world, the Government of Tanzania is urging its medical schools to train more physicians. The annual number of medical students admitted across the country rose from 55 in the 1990s to 1,680 approved places for the 2015/16 academic year. These escalating numbers strain existing faculty. OBJECTIVE: To describe the availability of faculty in medical schools in Tanzania. DESIGN: We identified faculty lists published on the Internet by five Tanzanian medical schools for the 2011/12 academic year and analyzed the appointment status, rank, discipline, and qualifications of faculty members...
2016: Global Health Action
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