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volume outcome relationship

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https://www.readbyqxmd.com/read/28815143/analyzing-electronic-medical-records-to-predict-risk-of-dit-death-intubation-or-transfer-to-icu-in-pediatric-respiratory-failure-or-related-conditions
#1
Teeradache Viangteeravat, Oguz Akbilgic, Robert Lowell Davis
Large volumes of data are generated in hospital settings, including clinical and physiological data generated during the course of patient care. Our goal, as proof of concept, was to identify early clinical factors or traits useful for predicting the outcome, of death, intubation, or transfer to ICU, for children with pediatric respiratory failure. We implemented both supervised and unsupervised methods to extend our understanding on statistical relationships in clinical and physiological data. As a supervised learning method, we use binary logistic regression to predict the risk of developing DIT outcome...
2017: AMIA Summits on Translational Science Proceedings
https://www.readbyqxmd.com/read/28814933/inflammatory-biomarkers-and-their-value-in-predicting-survival-and-outcome-among-patients-with-spontaneous-intracerebral-haemorrhage
#2
Senthil Kumar Rajapathy, Zamzuri Idris, Regunath Kandasamy, Albert Wong Sii Hieng, Jafri Malin Abdullah
BACKGROUND: Spontaneous intracerebral haemorrhage (SICH) has emerged as one of the most devastating forms of stroke in recent decades. This disease is noted to carry a 30-day mortality rate of approximately 45%. An increasing number of studies have implicated a complex immune-mediated and inflammation-mediated cascade of responses in the pathophysiology of SICH and the resultant neurologic outcome. Several clinical studies have demonstrated an association between inflammatory markers and outcome in patients with SICH...
May 2017: Malaysian Journal of Medical Sciences: MJMS
https://www.readbyqxmd.com/read/28808885/the-association-of-epicardial-fat-volume-with-coronary-characteristics-and-clinical-outcome
#3
Kohichiro Iwasaki, Norio Urabe, Atsushi Kitagawa, Toshihiko Nagao
Recent studies have demonstrated the relationship between epicardial fat volume (EFV) and coronary atherosclerosis, but their association is modest at best. Our purpose is to elucidate the association of epicardial fat with coronary characteristics and clinical outcome. We performed coronary computed tomographic angiography in 651 patients and divided them into three groups according to tertiles of EFV; low-tertile (n = 215), 36-123 ml; middle-tertile (n = 218), 124-165 ml; high-tertile (n = 218), 166-489 ml...
August 14, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/28807918/relationships-of-vancomycin-pharmacokinetics-to-body-size-and-composition-by-computed-tomography-analysis-a-novel-pharmacomorphomic-approach
#4
Manjunath P Pai, Brian A Derstine, Matt Lichty, Brian E Ross, June Sullivan, Grace L Su, Stewart C Wang
Antibiotics such as vancomycin are empirically dosed on body weight, which may not be optimal across the expanding adult body size distribution. Our aim was to compare the relationships between morphomic parameters generated from computed tomography images to conventional body size metrics as predictors of vancomycin pharmacokinetics (PK). This single center retrospective study included 300 patients with 1622 vancomycin concentration (52% trough) measurements. Bayesian estimation was used to compute individual vancomycin volume of distribution of the central compartment (Vc) and clearance (CL)...
August 14, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28803643/effect-of-surgeon-experience-with-laparoscopy-on-postoperative-outcomes-after-colorectal-surgery
#5
Faiz Gani, Marcelo Cerullo, XuFeng Zhang, Joseph K Canner, Alison Conca-Cheng, Alan E Hartzman, Syed G Husain, William C Cirocco, Amber L Traugott, Mark W Arnold, Fabian M Johnston, Timothy M Pawlik
BACKGROUND: Although the relationship between laparoscopic surgery and improved clinical outcomes has been well established across a variety of procedures, the effect of operative experience with laparoscopic surgery remains less defined. The present study sought to assess the comparative benefit of laparoscopic colorectal surgery relative to surgeon volume. METHODS: Commercially insured patients aged 18 to 64 years undergoing a colorectal resection were identified using the MarketScan Database from 2010-2014...
August 10, 2017: Surgery
https://www.readbyqxmd.com/read/28801298/-application-of-3d-visualization-technique-in-breast-cancer-surgery-with-immediate-breast-reconstruction-using-laparoscopically-harvested-pedicled-latissimus-dorsi-muscle-flap
#6
Pu-Sheng Zhang, Li-Kun Wang, Yun-Feng Luo, Fu-Jun Shi, Lin-Yun He, Cheng-Bing Zeng, Yu Zhang, Chi-Hua Fang
OBJECTIVE: To study the value of 3D visualization technique in breast-preserving surgery for breast cancer with immediate breast reconstruction using laparoscopically harvested pedicled latissimus dorsi muscle flap. METHODS: From January, 2015 to May, 2016, 30 patients with breast cancer underwent breast-preserving surgery with immediate breast reconstruction using pedicled latissimus dorsi muscle flap. The CT data of the arterial phase and venous phase were collected preoperatively and imported into the self-developed medical image 3D visualization system for image segmentation and 3D reconstruction...
August 20, 2017: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/28797422/in-hospital-outcomes-of-percutaneous%C3%A2-coronary-intervention-in%C3%A2-america-s-safety%C3%A2-net-insights-from-the-ncdr-cath-pci-registry
#7
Tushar Acharya, Adam C Salisbury, John A Spertus, Kevin F Kennedy, Amarbir Bhullar, H Kiran K Reddy, Bipin K Joshi, John A Ambrose
OBJECTIVES: This study compared risk-adjusted percutaneous coronary intervention (PCI) outcomes of safety-net hospitals (SNHs) and non-SNHs. BACKGROUND: Although risk adjustment is used to compare hospitals, SNHs treat a disproportionate share of uninsured and underinsured patients, who may have unmeasured risk factors, limited health care access, and poorer outcomes than patients treated at non-SNHs. METHODS: Using the National Cardiovascular Data Registry CathPCI Registry from 2009 to 2015, we analyzed 3,746,961 patients who underwent PCI at 282 SNHs (hospitals where ≥10% of PCI patients were uninsured) and 1,134 non-SNHs...
August 14, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28793975/infant-gut-microbiome-associated-with-cognitive%C3%A2-development
#8
Alexander L Carlson, Kai Xia, M Andrea Azcarate-Peril, Barbara D Goldman, Mihye Ahn, Martin A Styner, Amanda L Thompson, Xiujuan Geng, John H Gilmore, Rebecca C Knickmeyer
BACKGROUND: Studies in rodents provide compelling evidence that microorganisms inhabiting the gut influence neurodevelopment. In particular, experimental manipulations that alter intestinal microbiota impact exploratory and communicative behaviors and cognitive performance. In humans, the first years of life are a dynamic time in gut colonization and brain development, but little is known about the relationship between these two processes. METHODS: We tested whether microbial composition at 1 year of age is associated with cognitive outcomes using the Mullen Scales of Early Learning and with global and regional brain volumes using structural magnetic resonance imaging at 1 and 2 years of age...
June 27, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/28791500/correlation-of-volumetric-growth-and-histological-grade-in-50-meningiomas
#9
Wai Cheong Soon, Daniel M Fountain, Kacper Koczyk, Mutwakil Abdulla, Sachin Giri, Kieren Allinson, Tomasz Matys, Mathew R Guilfoyle, Ramez W Kirollos, Thomas Santarius
INTRODUCTION: Advances in radiological imaging techniques have enabled volumetric measurements of meningiomas to be easily monitored using serial imaging scans. There is limited literature on the relationship between tumour growth rates and the WHO classification of meningiomas despite tumour growth being a major determinant of type and timing of intervention. Volumetric growth has been successfully used to assess growth of low-grade glioma; however, there is limited information on the volumetric growth rate (VGR) of meningiomas...
August 9, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/28791494/adherence-with-perindopril-therapy-a-pilot-study-using-therapeutic-drug-monitoring-of-perindoprilat-and-an-evaluation-of-the-clearance-estimation
#10
Martin Šíma, Martin Vodička, Věra Marešová, Tomáš Šálek, Radomír Čabala, Ondřej Slanař
Background Although measurement of drug serum levels is an objective direct method for testing compliance, it can be distorted by "white-coat compliance" or by variations in drug elimination. Objective The aim of this prospective study was to evaluate the prevalence of noncompliance with perindopril therapy in adult out-patients using pharmacokinetic simulations. The additional aim was to compare the predictive performance of two glomerular filtration rate markers-creatinine and cystatin C. Setting Department of Cardiology, Tomas Bata Regional Hospital in Zlín, Czech Republic...
August 8, 2017: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/28780093/causal-effect-of-prolificacy-on-milk-yield-in-dairy-sheep-using-propensity-score
#11
Vera C Ferreira, David L Thomas, Bruno D Valente, Guilherme J M Rosa
In animal production, it is often important to investigate causal relationships among variables. The gold standard tool for such investigation is randomized experiments. However, randomized experiments may not always be feasible, possible, or cost effective or reflect real-world farm conditions. Sometimes it is necessary to infer effects from farm-recorded data. Inferring causal effects between variables from field data is challenging because the association between them may arise not only from the effect of one on another but also from confounding background factors...
August 2, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28777814/prevalence-of-preoperative-anemia-abnormal-mean-corpuscular-volume-and-red-cell-distribution-width-among-surgical-patients-in-singapore-and-their-influence-on-one-year-mortality
#12
Yilin Eileen Sim, Hide Elfrida Wee, Ai Leen Ang, Niresh Ranjakunalan, Biauw Chi Ong, Hairil Rizal Abdullah
INTRODUCTION: Preoperative anemia and high red cell distribution width (RDW) are associated with higher perioperative mortality. Conditions with high RDW levels can be categorized by mean corpuscular volume (MCV). The relationship between RDW, anemia and MCV may explain causality between high RDW levels and outcomes. We aim to establish the prevalence of preoperative anemia and distribution of RDW and MCV among pre-surgical patients in Singapore. In addition, we aim to investigate the association between preoperative anemia, RDW and MCV levels with one-year mortality after surgery...
2017: PloS One
https://www.readbyqxmd.com/read/28777197/elabela-improves-cardio-renal-outcome-in-fatal-experimental-septic-shock
#13
David Coquerel, Frédéric Chagnon, Xavier Sainsily, Lauralyne Dumont, Alexandre Murza, Jérôme Côté, Robert Dumaine, Philippe Sarret, Éric Marsault, Dany Salvail, Mannix Auger-Messier, Olivier Lesur
OBJECTIVES: Apelin-13 was recently proposed as an alternative to the recommended β-adrenergic drugs for supporting endotoxin-induced myocardial dysfunction. Since Apelin-13 signals through its receptor (Apelin peptide jejunum) to exert singular inotropic/vasotropic actions and to optimize body fluid balance, this candidate pathway might benefit septic shock management. Whether the newly discovered ELABELA (ELA), a second endogenous ligand of the Apelin peptide jejunum receptor highly expressed in the kidney, further improves cardio-renal impairment remains unknown...
August 2, 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/28760719/ambient-coarse-particulate-matter-and-the-right-ventricle-the-multi-ethnic-study-of-atherosclerosis
#14
Jennifer C D'Souza, Steven M Kawut, Laura R Elkayam, Lianne Sheppard, Peter S Thorne, David R Jacobs, David A Bluemke, Joao A C Lima, Joel D Kaufman, Timothy V Larson, Sara D Adar
BACKGROUND: Coarse particulate matter (PM10-2.5) is primarily mechanically generated and includes crustal material, brake and tire wear, and biological particles. PM10-2.5 is associated with pulmonary disease, which can lead to right ventricular (RV) dysfunction. Although RV characteristics have been associated with combustion-related pollutants, relationships with PM10-2.5 remain unknown. OBJECTIVES: To quantify cross-sectional associations between RV dysfunction and PM10-2...
July 27, 2017: Environmental Health Perspectives
https://www.readbyqxmd.com/read/28760395/institutional-experience-and-outcomes-of-transcatheter-aortic-valve-replacement-results-from-an-international-multicentre-registry
#15
Anthony W A Wassef, Sami Alnasser, Josep Rodes-Cabau, John G Webb, Marco Barbanti, Yaqing Liu, Antonio J Muñoz-García, Corrado Tamburino, Antonio E Dager, Vicenç Serra, Ignacio J Amat-Santos, Hatim Al Lawati, Marina Urena, Juan H Alonso Briales, Luis Miguel Benitez, Bruno García Del Blanco, Alberto San Roman, Akshay Bagai, Christopher E Buller, Mark D Peterson, Asim N Cheema
BACKGROUND: Despite rapidly increasing use of TAVR across institutions, limited data is available for the effect of procedural experience on TAVR outcomes. We investigate the relationship between institutional experience and TAVR outcomes. METHODS: 1953 patients undergoing TAVR at 8 international sites were grouped into chronological quantiles (Q) to assess temporal changes on procedural and clinical outcomes and multivariate logistic regression performed to determine predictors of device success, early safety and all-cause mortality...
July 24, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28756959/association-of-failed-root-canal-treatment-with%C3%A2-dentist-and-institutional-volumes-a%C3%A2-population-based-cohort-study-in-taiwan
#16
Chiachi Bonnie Lee, Ya-Hui Chang, Pei-Chun Wen, Chung-Yi Li
INTRODUCTION: The volume-outcome relationships in failed root canal treatments (RCTs) are rarely studied. Thus, we aimed to examine the association of failed RCTs with dentist and institutional volumes. METHODS: Ambulatory dental claims (2005-2010) of 1 million beneficiaries randomly selected from the National Health Insurance Research Database of Taiwan were used. This study is a population-based cohort study using a marginal Cox proportional hazards regression model in which the outcome variables cluster around individual patients...
July 27, 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/28755103/the-effect-of-weekly-set-volume-on-strength-gain-a-meta-analysis
#17
REVIEW
Grant W Ralston, Lon Kilgore, Frank B Wyatt, Julien S Baker
BACKGROUND: Strength training set organisation and its relationship to the development of muscular strength have yet to be clearly defined. Current meta-analytical research suggests that different population groups have distinctive muscular adaptations, primarily due to the prescription of the strength training set dose. OBJECTIVES: We conducted a meta-analysis with restrictive inclusion criteria and examined the potential effects of low (LWS), medium (MWS) or high weekly set (HWS) strength training on muscular strength per exercise...
July 28, 2017: Sports Medicine
https://www.readbyqxmd.com/read/28754109/prognostic-value-of-total-tumor-volume-in-patients-with-nasopharyngeal-carcinoma-treated-with-intensity-modulated-radiotherapy
#18
Shao-Bo Liang, Jian-Jian Teng, Xue-Feng Hu, Xing-Li Yang, Min Luo, Xiao-Na Fang, Dong-Sheng Liu, Yong Chen, Li-Wu Fu
BACKGROUND: Few studies have evaluated the prognostic value of total tumor volume (TTV), which reflects both the primary tumor volume and nodal tumor volume, in NPC. Furthermore, the relationship between TTV and survival remains unknown. The purpose of this study was to evaluate the prognostic value of TTV in patients with NPC treated with intensity-modulated radiation therapy (IMRT). METHODS: TTV was retrospectively assessed in 455 patients with newly diagnosed, non-metastatic NPC...
July 28, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28753874/systematic-review-of-the-volume-outcome-relationship-for-radical-prostatectomy-a-2017-update
#19
REVIEW
Jeffrey J Leow, Eugene K Leong, Emily C Serrell, Steven L Chang, Russell L Gruen, Keng Siang Png, Lisa T Beaule, Quoc-Dien Trinh, Mani M Menon, Jesse D Sammon
CONTEXT: Radical prostatectomy (RP) is one of the most complex urological procedures performed. Higher surgical volume has been found previously to be associated with better patient outcomes and reduced costs to the health care system. This has resulted in some regionalization of care toward high-volume facilities and providers; however, the preponderance of RPs is still performed at low-volume institutions. OBJECTIVE: To provide an updated systematic review of the association of hospital and surgeon volume on patient and system outcomes after RP, including robot-assisted RP...
April 6, 2017: European Urology Focus
https://www.readbyqxmd.com/read/28753795/postoperative-30-day-mortality-rates-for-kidney-cancer-are-dependent-on-hospital-surgical-volume-results-from-a-norwegian-population-based-study
#20
Karin M Hjelle, Tom B Johannesen, Christian Beisland
BACKGROUND: To improve cancer care in Norway, the government introduced surgical volume requirements for hospitals in 2015. To treat kidney cancer (KC) in Norway, the lower limit is 20 surgical procedures per year. OBJECTIVES: To compare the impact of hospital volume on outcome with regard to 30-d mortality (TDM) following KC surgery. DESIGN, SETTING, AND PARTICIPANTS: We identified all KC patients from the Cancer Registry of Norway diagnosed during 2008-2013 whose surgical treatment involved partial or radical nephrectomy...
October 22, 2016: European Urology Focus
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