keyword
https://read.qxmd.com/read/38535775/the-utility-of-spectroscopic-mri-in-stereotactic-biopsy-and-radiotherapy-guidance-in-newly-diagnosed-glioblastoma
#1
JOURNAL ARTICLE
Abinand C Rejimon, Karthik K Ramesh, Anuradha G Trivedi, Vicki Huang, Eduard Schreibmann, Brent D Weinberg, Lawrence R Kleinberg, Hui-Kuo G Shu, Hyunsuk Shim, Jeffrey J Olson
Current diagnostic and therapeutic approaches for gliomas have limitations hindering survival outcomes. We propose spectroscopic magnetic resonance imaging as an adjunct to standard MRI to bridge these gaps. Spectroscopic MRI is a volumetric MRI technique capable of identifying tumor infiltration based on its elevated choline (Cho) and decreased N-acetylaspartate (NAA). We present the clinical translatability of spectroscopic imaging with a Cho/NAA ≥ 5x threshold for delineating a biopsy target in a patient diagnosed with non-enhancing glioma...
March 20, 2024: Tomography: a Journal for Imaging Research
https://read.qxmd.com/read/38535769/the-relationship-between-liver-volume-clinicopathological-characteristics-and-survival-in-patients-undergoing-resection-with-curative-intent-for-non-metastatic-colonic-cancer
#2
JOURNAL ARTICLE
Josh McGovern, Charles Mackay, Rhiannon Freireich, Allan M Golder, Ross D Dolan, Paul G Horgan, David Holroyd, Nigel B Jamieson, Donald C McMillan
INTRODUCTION: The prognostic value of CT-derived liver volume in terms of cancer outcomes is not clear. The aim of the present study was to examine the relationship between liver area on a single axial CT-slice and the total liver volume in patients with colonic cancer. Furthermore, we examine the relationship between liver volume, determined using this novel method, clinicopathological variables and survival. METHODS: Consecutive patients who underwent potentially curative surgery for colonic cancer were identified from a prospectively maintained database...
February 28, 2024: Tomography: a Journal for Imaging Research
https://read.qxmd.com/read/38535103/impact-of-intracranial-volume-and-brain-volume-on-the-prognostic-value-of-computed-tomography-perfusion-core-volume-in-acute-ischemic-stroke
#3
JOURNAL ARTICLE
Jan W Hoving, Praneeta R Konduri, Manon L Tolhuisen, Miou S Koopman, Henk van Voorst, Laura M Van Poppel, Jasper D Daems, Adriaan C G M van Es, Marianne A A van Walderveen, Hester F Lingsma, Diederik W J Dippel, Wim H Van Zwam, Henk A Marquering, Charles B L M Majoie, Bart J Emmer
BACKGROUND: Computed tomography perfusion (CTP)-estimated core volume is associated with functional outcomes in acute ischemic stroke. This relationship might differ among patients, depending on brain volume. MATERIALS AND METHODS: We retrospectively included patients from the MR CLEAN Registry. Cerebrospinal fluid (CSF) and intracranial volume (ICV) were automatically segmented on NCCT. We defined the proportion of the ICV and total brain volume (TBV) affected by the ischemic core as ICVcore and TBVcore ...
February 28, 2024: Journal of Cardiovascular Development and Disease
https://read.qxmd.com/read/38533783/brain-morphometry-in-former-american-football-players-findings-from-the-diagnose-cte-research-project
#4
JOURNAL ARTICLE
Hector Arciniega, Zachary H Baucom, Fatima Tuz-Zahra, Yorghos Tripodis, Omar John, Holly Carrington, Nicholas Kim, Evdokiya E Knyazhanskaya, Leonard B Jung, Katherine Breedlove, Tim L T Wiegand, Daniel H Daneshvar, R Jarrett Rushmore, Tashrif Billah, Ofer Pasternak, Michael J Coleman, Charles H Adler, Charles Bernick, Laura J Balcer, Michael L Alosco, Inga K Koerte, Alexander P Lin, Jeffrey L Cummings, Eric M Reiman, Robert A Stern, Martha E Shenton, Sylvain Bouix
Exposure to repetitive head impacts (RHIs) in contact sports is associated with neurodegenerative disorders including chronic traumatic encephalopathy (CTE) which currently can be diagnosed only at postmortem. American football players are at higher risk of developing CTE given their exposure to RHIs. One promising approach for diagnosing CTE in vivo is to explore known neuropathological abnormalities at postmortem in living individuals using structural magnetic resonance imaging (MRI). MRI brain morphometry was evaluated in 170 male former American football players ages 45-74 years (n = 114 professional; n = 56 college) and 54 same-age unexposed asymptomatic male controls (n = 58 age range 45-74)...
March 27, 2024: Brain
https://read.qxmd.com/read/38533295/hemodynamic-determinants-of-cardiac-surgery-associated-acute-kidney-injury
#5
JOURNAL ARTICLE
Sevag Demirjian, Faisal Bakaeen, W H Wilson Tang, Chase Donaldson, Jon Taliercio, Anne Huml, Crystal A Gadegbeku, A Marc Gillinov, Steven Insler
OBJECTIVES: Examine the: 1) relative role of hemodynamic determinants of acute kidney injury (AKI) obtained in the immediate postcardiac surgery setting compared with established risk factors, 2) their predictive value, and 3) extent mediation via central venous pressure (CVP) and mean arterial pressure (MAP). DESIGN: Retrospective observational study. The main outcome of the study was moderate to severe AKI, per kidney disease: improving global outcomes, within 14 days of surgery...
April 2024: Critical care explorations
https://read.qxmd.com/read/38532271/antithrombotics-in-the-fall-patient-appropriateness-and-risk-benefit-analysis
#6
JOURNAL ARTICLE
A J Bethurum, Kevin Zeng, Thaddeus Puzdrakiewicz, Parth Goenka, Hannah Collins, J Bracken Burns, Keelin Roche
Falls are the leading cause of hospitalizations following trauma nationwide, resulting in over 3 million admissions in 2020. This population is typically aged, and many are prescribed antithrombotic (AT) therapy. In this prospective study, we aimed to analyze fall history while assessing appropriateness of AT regimen relative to fall risk. Patients presenting following ground level fall (GLF) and meeting inclusion criteria during the study period were enrolled. Primary outcome was the relationship between AT therapy necessity (CHA2 DS2 -VASc) and fall risk (Morse Fall Risk)...
March 26, 2024: American Surgeon
https://read.qxmd.com/read/38532122/the-influence-of-hospital-volume-and-physician-volume-on-early-mortality-in-acute-promyelocytic-leukemia-patients
#7
JOURNAL ARTICLE
Chia-Ying Wu, Chiu-Mei Yeh, Chun-Kuang Tsai, Chia-Jen Liu
Acute promyelocytic leukemia (APL) is a highly curable hematologic malignancy in the era of all-trans retinoic acid (ATRA) combination treatment. However, only a modest change in early mortality rate has been observed despite the wide availability of ATRA. In addition to the clinical characteristics of APL patients, studies on the hospital volume-outcome relationship and the physician volume-outcome relationship remained limited. We aim to evaluate the association between hospital and physician volume and the early mortality rate among APL patients...
March 26, 2024: Annals of Hematology
https://read.qxmd.com/read/38530051/vessel-and-airway-characteristics-in-one-year-ct-defined-rapid-emphysema-progression-spiromics
#8
JOURNAL ARTICLE
Sarah E Gerard, Timothy M Dougherty, Prashant Nagpal, Dakai Jin, MeiLan K Han, John D Newell, Punam K Saha, Alejandro P Comellas, Christopher B Cooper, David Couper, Spyridon Fortis, Junfeng Guo, Nadia N Hansel, Richard E Kanner, Ella A Kazeroni, Fernando J Martinez, Amin Motahari, Robert Paine Iii, Stephen Rennard, Joyce D Schroeder, Prescott G Woodruff, R Graham Barr, Benjamin M Smith, Eric A Hoffman
Rationale: Rates of emphysema progression vary in chronic obstructive pulmonary disease (COPD), and the relationship with vascular and airway pathophysiology remain unclear. Objective: We sought to determine if indices of peripheral (segmental and beyond) pulmonary arterial (PA) dilation measured via computed tomography (CT) are associated with a 1-year index of emphysema (EI: %voxels<-950HU) progression. Methods: 599 GOLD 0-3 former and never-smokers were evaluated from the SubPopulations and InterMediate Outcome Measures in COPD Study (SPIROMICS) cohort: rapid-emphysema-progressors (RP, n=188; 1-year ΔEI>1%), non-progressors (NP, n=301; 1-year ΔEI±0...
March 26, 2024: Annals of the American Thoracic Society
https://read.qxmd.com/read/38529358/-helicobacter-pylori-persistent-infection-burden-and-structural-brain-imaging-markers
#9
JOURNAL ARTICLE
May A Beydoun, Hind A Beydoun, Yi-Han Hu, Ziad W El-Hajj, Michael F Georgescu, Nicole Noren Hooten, Zhiguang Li, Jordan Weiss, Donald M Lyall, Shari R Waldstein, Dawson W Hedges, Shawn D Gale, Lenore J Launer, Michele K Evans, Alan B Zonderman
Persistent infections, whether viral, bacterial or parasitic, including Helicobacter pylori infection, have been implicated in non-communicable diseases, including dementia and other neurodegenerative diseases. In this cross-sectional study, data on 635 cognitively normal participants from the UK Biobank study (2006-21, age range: 40-70 years) were used to examine whether H. pylori seropositivity (e.g. presence of antibodies), serointensities of five H. pylori antigens and a measure of total persistent infection burden were associated with selected brain volumetric structural MRI (total, white, grey matter, frontal grey matter (left/right), white matter hyperintensity as percent intracranial volume and bi-lateral sub-cortical volumes) and diffusion-weighted MRI measures (global and tract-specific bi-lateral fractional anisotropy and mean diffusivity), after an average 9-10 years of lag time...
2024: Brain communications
https://read.qxmd.com/read/38528780/ct-perfusion-based-rcbf-38-volume-is-independently-and-negatively-associated-with-digital-subtraction-angiography-collateral-score-in-anterior-circulation-large-vessel-occlusions
#10
JOURNAL ARTICLE
Dhairya A Lakhani, Aneri B Balar, Manisha Koneru, Sijin Wen, Burak Berksu Ozkara, Richard Wang, Meisam Hoseinyazdi, Mehreen Nabi, Ishan Mazumdar, Andrew Cho, Kevin Chen, Sadra Sepehri, Nathan Hyson, Risheng Xu, Victor Urrutia, Licia Luna, Argye E Hillis, Jeremy J Heit, Greg W Albers, Ansaar T Rai, Vivek S Yedavalli
BACKGROUND: Collateral status (CS) is an important biomarker of functional outcomes in patients with acute ischemic stroke secondary to large vessel occlusion (AIS-LVO). Pretreatment CT perfusion (CTP) parameters serve as reliable surrogates of collateral status (CS). In this study, we aim to assess the relationship between the relative cerebral blood flow less than 38% (rCBF <38%), with the reference standard American Society of Interventional and Therapeutic Neuroradiology (ASITN) collateral score (CS) on DSA...
March 25, 2024: Neuroradiology Journal
https://read.qxmd.com/read/38528484/umbilical-cord-blood-cell-characteristics-in-very-preterm-neonates-for-autologous-cell-therapy-of-preterm-associated-complications
#11
JOURNAL ARTICLE
Ren Zhuxiao, Han Jiangxue, Li Yongsheng, Pei Jingjun, Yang Shuo, Xu Fang, Zhang Qi, Zhang Shandan, Nie Chuan, Yang Jie
BACKGROUND: There are emerging clinical evidence for umbilical cord blood mononuclear cells (UCBMNCs) intervention to improve preterm complications. The first critical step in cell therapy is to obtain high-quality cells. This retrospective study aimed to investigate the quantity and quality of UCBMNCs from very preterm infants (VPIs) for the purpose of autologous cell therapy in prevention and treatment of preterm complications. METHODS: Very preterm infants (VPIs) born in Guangdong Women and Children Hospital from January 1, 2017, to December 8, 2022, from whom cord blood was successfully collected and separated for public or private banking, were enrolled...
March 25, 2024: BMC Pediatrics
https://read.qxmd.com/read/38527245/size-and-location-of-preterm-brain-injury-and-associations-with-neurodevelopmental-outcomes
#12
JOURNAL ARTICLE
Thiviya Selvanathan, Ting Guo, Steven Ufkes, Vann Chau, Helen Branson, Anne Synnes, Linh G Ly, Edmond N Kelly, Ruth E Grunau, Steven P Miller
BACKGROUND AND OBJECTIVES: We examined associations of white matter injury (WMI) and periventricular hemorrhagic infarction (PVHI) volume and location with 18-month neurodevelopment in very preterm infants. METHODS: A total of 254 infants born <32 weeks' gestational age were prospectively recruited across 3 tertiary neonatal intensive care units (NICUs). Infants underwent early-life (median 33.1 weeks) and/or term-equivalent-age (median 41.9 weeks) MRI. WMI and PVHI were manually segmented for quantification in 92 infants...
April 23, 2024: Neurology
https://read.qxmd.com/read/38526500/the-role-of-geriatric-nutritional-risk-index-as-a-predictor-for-postoperative-outcomes-in-gastrointestinal-emergencies
#13
JOURNAL ARTICLE
Yasuhiro Takano, Yasunobu Kobayashi, Tomohiro Kudo, Sumika Takahashi, Hironori Kanno, Nobuyoshi Hanyu
BACKGROUND: The geriatric nutritional risk index (GNRI) is a simple nutritional and inflammatory marker for older adults. The aim of the present study was to investigate the usefulness of the GNRI in older adults who underwent emergency gastrointestinal surgery. METHODS: This study included 206 older adults who had undergone emergency gastrointestinal surgery. We retrospectively investigated the relationship between the GNRI and postoperative complications. Univariate and multivariate analyses were performed to evaluate risk factors for postoperative complications...
January 2024: World Journal of Surgery
https://read.qxmd.com/read/38525855/high-but-decreasing-rates-of-reconstruction-after-total-proctocolectomy-for-ulcerative-colitis-and-evidence-of-a-direct-volume-outcome-relationship
#14
JOURNAL ARTICLE
Hugh L Giddings, Kheng-Seong Ng, Michael J Solomon, Daniel Steffens, Joe Van Buskirk, Jane Young
BACKGROUND: Total (procto)colectomy is indicated in 15%-20% of ulcerative colitis(UC) patients during their disease course. Reconstruction options to avoid a permanent ileostomy include an ileoanal pouch anastomosis (IPAA) or ileorectal anastomosis (IRA). This study aimed to investigate reconstruction rates using Australian-based population-level data, and factors influencing reconstruction. METHODS: A retrospective data linkage study of the NSW population over a 19-year period was performed...
March 25, 2024: ANZ Journal of Surgery
https://read.qxmd.com/read/38523304/a-post-diagnosis-information-and-support-programme-for-dyads-people-living-with-dementia-or-mild-cognitive-impairment-and-family-carers-a-feasibility-study
#15
JOURNAL ARTICLE
Gillian Stockwell-Smith, Wendy Moyle, Laurie Grealish, Tracy Comans, Paul Varghese, Carol Whitlatch, Silvia Orsulic-Jeras
AIM: The aim of the study was to establish the feasibility of delivering a structured post-diagnosis information and support program to dyads (persons living with dementia or mild cognitive impairment and family carers) in two primary care settings. DESIGN: A two-phase explanatory mixed-method approach guided by the Bowen Feasibility Framework focused on acceptability, implementation, adaptation, integration and efficacy of a five-part programme. In phase 1, the quantitative impact of the programme on the dyadic programme recipients' self-efficacy, quality of life, dyadic relationship and volume of care was measured...
March 24, 2024: Journal of Advanced Nursing
https://read.qxmd.com/read/38522961/hypofractionated-whole-breast-imrt-with-hdr-brachytherapy-boost-in-early-stage-breast-cancer-long-term-results-from-a-single-center
#16
JOURNAL ARTICLE
Ana Aurora Díaz-Gavela, Elia Del Cerro Peñalver, Sofía Sanchez-Garcia, Eduardo Pardo-Perez, Israel John Thuissard-Vasallo, Cristina Andreu-Vázquez, María Yolanda Molina López, Marina Pena Huertas, Luis Leonardo Guerrero-Gómez, David Sanz-Rosa, Felipe Counago Lorenzo
INTRODUCTION/OBJECTIVES: The addition of a boost to the lumpectomy bed after whole-breast (WB) radiotherapy plays a key role in the treatment of patients with breast cancer (BC). The clinical benefits of a boost with high-dose-rate brachytherapy (HDR-BT) after conventional fractionation is supported by a large body of evidence. However, few studies have described its outcomes after a hypofractionated scheme. MATERIALS AND METHODS: We included all patients treated with adjuvant WB-IMRT in 15 sessions followed by a single-session HDR-BT boost with local anesthesia on an outpatient basis...
March 23, 2024: Brachytherapy
https://read.qxmd.com/read/38521181/relationship-between-lung-volumes-and-heterogeneity-in-the-response-to-elexacaftor-tezacaftor-ivacaftor-in-patients-with-cystic-fibrosis-and-advanced-lung-disease
#17
JOURNAL ARTICLE
Andrea Gramegna, Gianfranco Alicandro, Chiara Premuda, Francesca Lucca, Lucia Pinali, Mariangela Retucci, Valentina Vespro, Maria Carmela Andrisani, Gianpaolo Carraffiello, Francesco Amati, Sonia Volpi, Stefano Aliberti, Marco Cipolli, Francesco Blasi
BACKGROUND: The effects of elexacaftor/tezacaftor/ivacaftor (ETI) on respiratory outcomes for people with CF (pwCF) were demonstrated by several clinical trials, mainly based on simple spirometry. However, gains in lung function may vary greatly between patients, but predictors of FEV1 change after treatment are still missing. RESEARCH QUESTION: Which ventilatory parameters are involved in the heterogeneity of FEV1 change after 12-month ETI treatment in pwCF with advanced lung disease? STUDY DESIGN: AND METHODS: This was a multicenter, observational, prospective cohort study at two major CF centers in Italy...
March 21, 2024: Chest
https://read.qxmd.com/read/38518026/neutrophil-to-lymphocyte-ratio-on-admission-predicts-early-perihematomal-edema-growth-after-intracerebral-hemorrhage
#18
JOURNAL ARTICLE
Yirong Mao, Lumao Huang, Gengsheng Ji, Liang Wang, Xiang Wang, Xinyi Zheng
Poor functional outcome is associated with perihematomal edema (PHE) expansion after intracerebral hemorrhage (ICH). The inflammatory response is crucial for the onset and progression of PHE. This study aimed to determine the connection between admission neutrophil-lymphocyte ratio (NLR) and early PHE development. We retrospectively analyzed patients with ICH admitted to the Chaohu Affiliated Hospital of Anhui Medical University from January 2021 to December 2022. The primary outcome measure was absolute PHE, defined as the volume of the follow-up PHE minus admission PHE...
March 22, 2024: Medicine (Baltimore)
https://read.qxmd.com/read/38515572/cigarette-smoking-and-mammographic-breast-density-in-post-menopausal-women-from-the-epic-florence-cohort
#19
JOURNAL ARTICLE
Benedetta Bendinelli, Saverio Caini, Melania Assedi, Ilaria Ermini, Elisa Pastore, Luigi Facchini, Maria Antonietta Gilio, Giacomo Duroni, Miriam Fontana, Andrea Querci, Daniela Ambrogetti, Calogero Saieva, Giovanna Masala
INTRODUCTION: Cigarette smoking has been recognized as a risk factor for breast cancer (BC) also if the biological mechanism remains poorly understood. High mammographic breast density (MBD) is associated with BC risk and many BC risk factors, such as genetic, anthropometric, reproductive and lifestyle factors and age, are also able to modulate MBD. The aim of the present study was to prospectively explore, in post-menopausal women, the association between smoking habits and MBD, assessed using an automated software, considering duration and intensity of smoking...
2024: Frontiers in Oncology
https://read.qxmd.com/read/38514287/the-relationship-between-patient-volume-and-mortality-in-nsw-major-trauma-service-hospitals
#20
JOURNAL ARTICLE
Alan A Garner, Leela Sai Krishna Suryadevara, Charlie Sewalt, Stuart Lane, Rajneesh Kaur
INTRODUCTION: Conventional wisdom is that Major Trauma Services (MTS) treating larger volumes of severe trauma patients will have better outcomes than lower volume centres, but recent studies from Europe have questioned this relationship. We aimed to determine if there is a relationship between patient volume and outcome in New South Wales (NSW) MTS hospitals. MATERIALS AND METHODS: Retrospective observational study using data from the NSW State Trauma Registry from 2010 to 2019 inclusive...
March 15, 2024: Injury
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