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https://www.readbyqxmd.com/read/29163566/cultivar-diversity-of-grape-skin-polyphenol-composition-and-changes-in-response-to-drought-investigated-by-lc-ms-based-metabolomics
#1
Lucie Pinasseau, Anna Vallverdú-Queralt, Arnaud Verbaere, Maryline Roques, Emmanuelle Meudec, Loïc Le Cunff, Jean-Pierre Péros, Agnès Ageorges, Nicolas Sommerer, Jean-Claude Boulet, Nancy Terrier, Véronique Cheynier
Phenolic compounds represent a large family of plant secondary metabolites, essential for the quality of grape and wine and playing a major role in plant defense against biotic and abiotic stresses. Phenolic composition is genetically driven and greatly affected by environmental factors, including water stress. A major challenge for breeding of grapevine cultivars adapted to climate change and with high potential for wine-making is to dissect the complex plant metabolic response involved in adaptation mechanisms...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29158881/serum-proteomic-profiling-of-obsessive-compulsive-disorder-washing-subtype-a-preliminary-study
#2
Mona Zamanian-Azodi, Mostafa Rezaei-Tavirani, Naser Nejadi, Afsaneh Arefi Oskouie, Faird Zayeri, Mostafa Hamdieh, Akram Safaei, Majid Rezaei-Tavirani, Alireza Ahmadzadeh, Alireza Amouzandeh-Nobaveh, Farshad Okhovatian
Introduction: Obsessive-Compulsive Disorder (OCD) is a disabling mental condition that its proteomic profiling is not yet investigated. Proteomics is a valuable tool to discover biomarker approaches. It can be helpful to detect protein expression changes in complex disorders such as OCD. Methods: Here, by the application of 2D gel electrophoresis (2DE), a pilot study of serum proteome profile of females with washing subtype of OCD was performed. Serum samples were obtained from females with washing subtype of OCD...
July 2017: Basic and Clinical Neuroscience
https://www.readbyqxmd.com/read/29137021/effect-of-antitumor-treatments-on-triple-negative-breast-cancer-patients-a-prisma-compliant-network-meta-analysis-of-randomized-controlled-trials
#3
Qiuhong Tian, Peng Du, Sen Li, Zhenzhu Bai, Yong Yang, Jinsheng Zeng
BACKGROUND: Triple-negative breast cancer (TNBC) lacks the expression of the estrogen receptor, progesterone receptor, and receptor tyrosine-protein kinase erbB-2 (HER2/neu), which renders hormone-related endocrine and targeted therapy essentially futile. OBJECTIVE: We performed a meta-analysis to assess the effects of antitumor regimens in the treatment of TNBC patients. METHODS: We searched electronic databases, including PubMed, Embase, and the Cochrane Library, through January 2017 using the following keywords: "triple negative breast cancer," "TNBC," and "random*" without language restrictions...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29126163/identification-of-novel-cancer-biomarkers-of-prognostic-value-using-specific-gene-regulatory-networks-grn-a-novel-role-of-rad51ap1-for-ovarian-and-lung-cancers
#4
Dimple Chudasama, Valeria Bo, Marcia Hall, Vladimir Anikin, Jeyarooban Jeyaneethi, Jane Gregory, George Pados, Allan Tucker, Amanda Harvey, Ryan Pink, Emmanouil Karteris
To date, microarray analyses have led to the discovery of numerous individual "molecular signatures" associated with specific cancers. However, there are serious limitations for the adoption of these multi-gene signatures in the clinical environment for diagnostic or prognostic testing as studies with more power need to be carried out. This may involve larger richer cohorts and more advanced analyses.In this study, we conduct analyses -based on GRN- to reveal distinct and common biomarkers across cancer types...
November 8, 2017: Carcinogenesis
https://www.readbyqxmd.com/read/29125125/bogdanov-takens-bifurcation-in-a-neutral-bam-neural-networks-model-with-delays
#5
Runxia Wang, Haihong Liu, Fei Feng, Fang Yan
In this study, the authors first discuss the existence of Bogdanov-Takens and triple zero singularity of a five neurons neutral bidirectional associative memory neural networks model with two delays. Then, by utilising the centre manifold reduction and choosing suitable bifurcation parameters, the second-order and the third-order normal forms of the Bogdanov-Takens bifurcation for the system are obtained. Finally, the obtained normal form and numerical simulations show some interesting phenomena such as the existence of a stable fixed point, a pair of stable non-trivial equilibria, a stable limit cycles, heteroclinic orbits, homoclinic orbits, coexistence of two stable non-trivial equilibria and a stable limit cycles in the neighbourhood of the Bogdanov-Takens bifurcation critical point...
December 2017: IET Systems Biology
https://www.readbyqxmd.com/read/29120615/acentric-la3-io3-8-oh-and-la-io3-2-no3-partial-substitution-of-iodate-anions-in-la-io3-3-by-hydroxide-or-nitrate-anion
#6
Fei-Fei Mao, Chun-Li Hu, Bing-Xuan Li, Jiang-Gao Mao
Partial substitution of iodate anions in La(IO3)3 by OH(-) or NO3(-) anion led to acentric La3(IO3)8(OH) and chiral La(IO3)2(NO3). The structure of La3(IO3)8(OH) can be seen as a complex three-dimensional (3D) network composed of two-dimensional [La3(IO3)2(OH)](6+) cationic layers that are further bridged by remaining iodate anions, or alternatively as a 3D network composed of one-dimensional [La3(IO3)6(OH)](2+) cationic columns being further interconnected by additional iodate anions, while the structure of La(IO3)2(NO3) can be seen as a novel 3D structure with planar NO3 groups serving as linkage between the [La3(IO3)6](3+) triple layers...
November 9, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/29119594/uniform-national-guidelines-do-not-prevent-wide-variations-in-the-clinical-application-of-phototherapy-for-neonatal-jaundice
#7
Khalaf Mreihil, Britt Nakstad, Hans Jørgen Stensvold, Jūratė Šaltytė Benth, Thor Willy Ruud Hansen
AIM: This study compared the use of phototherapy for neonatal jaundice in all 21 Norwegian neonatal intensive care units (NICUs) from 2013-2014 in order to improve practice. METHODS: Information on all types of phototherapy devices were collected and irradiance was measured from random units at 20cm and 50cm from the light source. We gathered information on local practice rules, including the use of single, double or triple phototherapy, how infants were positioned, the frequency of blood sampling, rules for using reflective surfaces and interrupting phototherapy...
November 8, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/29109026/a-low-friction-biphasic-and-boundary-lubricating-hydrogel-for-cartilage-replacement
#8
Piers E Milner, Maria Parkes, Jennifer L Puetzer, Robert Chapman, Molly M Stevens, Philippa Cann, Jonathan Jeffers
Partial joint repair is a surgical procedure where an artificial material is used to replace localised chondral damage. These artificial bearing surfaces must articulate against cartilage, but current materials do not replicate both the biphasic and boundary lubrication mechanisms of cartilage. A research challenge therefore exists to provide a material that mimics both boundary and biphasic lubrication mechanisms of cartilage. In this work a polymeric network of a biomimetic boundary lubricant, poly(2-methacryloyloxyethyl phosphorylcholine) (PMPC), was incorporated into an ultra-tough double network (DN) biphasic (water phase + polymer phase) gel, to form a PMPC triple network (PMPC TN) hydrogel with boundary and biphasic lubrication capability...
November 3, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/29107054/selecting-the-correct-cellular-model-for-assessing-of-the-biological-response-of-collagen-based-biomaterials
#9
Natalia Davidenko, Samir Hamaia, Daniel V Bax, Jean-Daniel Malcor, Carlos F Schuster, Donald Gullberg, Richard W Farndale, Serena M Best, Ruth E Cameron
Accurate evaluation of the biological performance of biomaterials requires the correct assessment of their native-like cell ligation properties. However, cell attachment studies often overlook the details of the substrate-cell binding mechanisms, be they integrin-mediated or non-specific, and ignore the class- and species-specificities of the cell adhesion receptor involved. In this work we have used different collagen (Col) substrates (fibrillar collagens I, II and III and network-forming Col IV), containing different affinity cell-recognition motifs, to establish the influence of the receptor identity and species-specificity on collagen-cell interactive properties...
October 26, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/29104043/unveiling-the-water-associated-conformational-mobility-in-the-active-site-of-ascorbate-peroxidase
#10
Wei-Chih Chao, Li-Ju Lin, Jyh-Feng Lu, Jinn-Shyan Wang, Tzu-Chieh Lin, Yi-Han Chen, Yi-Ting Chen, Hsiao-Ching Yang, Pi-Tai Chou
We carried out comprehensive spectroscopic studies of wild type and mutants of ascorbate peroxidase (APX) to gain understanding of the conformational mobility of the active site. In this approach, three unnatural tryptophans were applied to replace the distal tryptophan (W41) in an aim to probe polarity/water environment near the edge of the heme-containing active site. 7-azatryptophan ((7-aza)Trp) is sensitive to environment polarity, while 2,7-azatryptophan ((2,7-aza)Trp) and 2,6-diazatryptophan ((2,6-aza)Trp) undergo excited-state water-catalyzed double and triple proton transfer, respectively, and are sensitive to the water network...
November 2, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29094413/fluoxetine-induces-autophagic-cell-death-via-eef2k-ampk-mtor-ulk-complex-axis-in-triple-negative-breast-cancer
#11
Dejuan Sun, Lingjuan Zhu, Yuqian Zhao, Yingnan Jiang, Lixia Chen, Yang Yu, Liang Ouyang
OBJECTIVES: Triple negative breast cancer (TNBC) is a complex and intrinsically aggressive tumour with poor prognosis, and the discovery of targeted small-molecule drugs for TNBC treatment still remains in its infancy. In this study, we aimed to discover a small-molecule agent for TNBC treatment and illuminate its potential mechanisms. MATERIALS AND METHODS: Cell viability was detected by using methylthiazoltetrazolium (MTT) assay. Electron microscopy, GFP-LC3 transfection, monodansylcadaverine staining and apoptosis assay were performed to determine Fluoxetine-induced autophagy and apoptosis...
November 1, 2017: Cell Proliferation
https://www.readbyqxmd.com/read/29093275/neutralization-of-il-8-decreases-tumor-pmn-mdscs-and-reduces-mesenchymalization-of-claudin-low-triple-negative-breast-cancer
#12
Charli Dominguez, Kristen K McCampbell, Justin M David, Claudia Palena
The complex signaling networks of the tumor microenvironment that facilitate tumor growth and progression toward metastatic disease are becoming a focus of potential therapeutic options. The chemokine IL-8 is overexpressed in multiple cancer types, including triple-negative breast cancer (TNBC), where it promotes the acquisition of mesenchymal features, stemness, resistance to therapies, and the recruitment of immune-suppressive cells to the tumor site. The present study explores the utility of a clinical-stage monoclonal antibody that neutralizes IL-8 (HuMax-IL8) as a potential therapeutic option for TNBC...
November 2, 2017: JCI Insight
https://www.readbyqxmd.com/read/29069421/comparative-efficacy-and-safety-of-treatment-options-for-mdr-and-xdr-acinetobacter-baumannii-infections-a-systematic-review-and-network-meta-analysis
#13
Kirati Kengkla, Khachen Kongpakwattana, Surasak Saokaew, Anucha Apisarnthanarak, Nathorn Chaiyakunapruk
Objectives: To comprehensively compare and rank the efficacy and safety of available treatment options for patients with MDR and XDR Acinetobacter baumannii (AB) infection. Methods: We searched PubMed, Embase and the Cochrane register of trials systematically for studies that examined treatment options for patients with MDR- and XDR-AB infections until April 2016. Network meta-analysis (NMA) was performed to estimate the risk ratio (RR) and 95% CI from both direct and indirect evidence...
October 24, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29067371/a-ring-polymer-molecular-dynamics-study-of-the-oh-h2-d2-reaction
#14
J F Castillo, Y V Suleimanov
In this work we have performed a ring polymer molecular dynamics (RPMD) study of the OH + H2 and OH + D2 reactions at temperatures ranging from 150 K to 2000 K using two available ab initio potential energy surfaces (PESs) that have been termed as the YZCL2 and NN1 PES, respectively. The YZCL2 PES was developed by Yang et al. [J. Chem. Phys., 2001, 115(1), 174] which is based on points fitted by a modified Shephard interpolation method and calculated with unrestricted coupled-cluster theory with all single and double excitations and a perturbative account of the triple excitations (UCCSD(T)) method with an aug-cc-pVQZ basis...
November 8, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29062900/microbiota-diversification-and-crash-induced-by-dietary-oxalate-in-the-mammalian-herbivore-neotoma-albigula
#15
Aaron W Miller, Colin Dale, M Denise Dearing
Oxalate, broadly found in both dietary and endogenous sources, is a primary constituent in 80% of kidney stones, an affliction that has tripled in prevalence over the last 40 years. Oxalate-degrading bacteria within the gut microbiota can mitigate the effects of oxalate and are negatively correlated with kidney stone formation, but bacteriotherapies involving oxalate-degrading bacteria have met with mixed results. To inform the development of more effective and consistent bacteriotherapies, we sought to quantify the interactions and limits between oxalate and an oxalate-adapted microbiota from the wild mammalian herbivore Neotoma albigula (woodrat), which consumes a high-oxalate diet in the wild...
September 2017: MSphere
https://www.readbyqxmd.com/read/29055701/self-healing-and-tough-hydrogels-with-physically-cross-linked-triple-networks-based-on-agar-pva-graphene
#16
Navid Samadi, Mohammad Sabzi, Masoud Babaahmadi
The aim of this work was to prepare polyvinyl alcohol (PVA)/Agar/Graphene nanocomposite hydrogels through a one-pot and green solution mixing method using water as solvent. Herein a novel strategy for designing stiff, tough and self-healing triple network (TN) hydrogels was proposed. The prepared TN hydrogels composed of strong Agar polysaccharide as the first network, tough PVA biopolymer gel as the second network, and graphene nanoplatelets as the third network. Interestingly, similar to natural biomaterials, all of the networks of the nanocomposite hydrogel were physically cross-linked via dynamic hydrogen bonding associations, i...
October 18, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29051108/a-bayesian-model-that-jointly-considers-comparative-effectiveness-research-and-patients-preferences-may-help-inform-grade-recommendations-an-application-to-rheumatoid-arthritis-treatment-recommendations
#17
Glen S Hazlewood, Claire Bombardier, George Tomlinson, Deborah Marshall
OBJECTIVE: To estimate the preferred treatment for early rheumatoid arthritis (ERA) using a novel Bayesian approach that jointly considers patients' preferences and comparative effectiveness research STUDY DESIGN AND SETTING: We estimated the preferred treatment by using patients' preferences measured in a discrete-choice experiment to apply weights to benefit and harm outcomes from a network meta-analysis, and other considerations (dosing, rare adverse events). Using Bayesian analyses, we considered the variability in patients' preferences and the imprecision in both patients' preferences and the treatment effects; all key considerations in the GRADE approach...
October 16, 2017: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/29029891/imaging-findings-within-the-first-12%C3%A2-months-of-hepatocellular-carcinoma-treated-with-stereotactic-body-radiation-therapy
#18
Mishal Mendiratta-Lala, Everett Gu, Dawn Owen, Kyle C Cuneo, Latifa Bazzi, Theodore S Lawrence, Hero K Hussain, Matthew S Davenport
PURPOSE: To correlate the imaging findings of treated hepatocellular carcinoma (HCC) after stereotactic body radiation therapy (SBRT) with explant pathology and alpha-fetoprotein (AFP) response. METHODS AND MATERIALS: From 2007 to 2015, of 146 patients treated with liver SBRT for Barcelona Clinic Liver Cancer stage A hepatocellular carcinoma, 10 were identified with inclusion criteria and had regular interval follow-up magnetic resonance imaging/triple phase computed tomography and explant pathology or declining AFP values for radiology-pathology response correlation...
August 24, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29023526/antithrombotic-therapy-strategies-for-atrial-fibrillation-patients-undergoing-percutaneous-coronary-intervention-a-systematic-review-and-network-meta-analysis
#19
REVIEW
Xiaoxuan Gong, Shaowen Tang, Jiangjin Li, Xiwen Zhang, Xiaoyi Tian, Shuren Ma
OBJECTIVE: The aim of this systematic review and network meta-analysis was to evaluate the comparative efficacy and safety of antiplatelet agents, vitamin K antagonist (VKA) and non-VKA oral anticoagulants (NOACs) in patients with atrial fibrillation (AF) undergoing percutaneous coronary intervention (PCI). METHODS: PubMed, EMBASE, and the Cochrane Central Register of Controlled Trials were searched to identify clinical trials comparing antiplatelet drugs with VKA and NOACs or their combination in AF patients undergoing PCI with a mean/median follow-up of at least 12 months...
2017: PloS One
https://www.readbyqxmd.com/read/28992406/constructing-an-anisotropic-triple-pass-tubular-framework-within-a-lyophilized-porous-gelatin-scaffold-using-dexamethasone-loaded-functionalized-whatman-paper-to-reinforce-its-mechanical-strength-and-promote-osteogenesis
#20
Jiabing Ran, Hao Zeng, Janak Lal Pathak, Pei Jiang, Yi Bai, Pan Yan, Guanglin Sun, Xinyu Shen, Hua Tong, Bin Shi
In bone tissue engineering (BTE), most of the currently developed scaffolds still lack the ability to demonstrate high porosity and high mechanical strength simultaneously or the ability to maintain bioactivity and sustained release of loaded biofactors. In this work, we constructed an anisotropic triple-pass tubular framework within a lyophilized porous GEL scaffold using FP, which was prepared by coating DEX-covered Whatman paper (WP) using the silk fibroin (SF) membrane with β-sheet conformation. This novel structural design endowed the functionalized paper frame (FPF)/scaffold implant high porosity, high mechanical strength, and sustained DEX delivery capability...
October 16, 2017: Biomacromolecules
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