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https://www.readbyqxmd.com/read/28918577/microarray-based-snp-genotyping-to-identify-genetic-risk-factors-of-triple-negative-breast-cancer-tnbc-in-south-indian-population
#1
M Aravind Kumar, Vineeta Singh, Shaik Mohammad Naushad, Uday Shanker, M Lakshmi Narasu
In the view of aggressive nature of Triple-Negative Breast cancer (TNBC) due to the lack of receptors (ER, PR, HER2) and high incidence of drug resistance associated with it, a case-control association study was conducted to identify the contributing genetic risk factors for Triple-negative breast cancer (TNBC). A total of 30 TNBC patients and 50 age and gender-matched controls of Indian origin were screened for 9,00,000 SNP markers using microarray-based SNP genotyping approach. The initial PLINK association analysis (p < 0...
September 16, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28917892/a-mechanism-for-the-synergistic-gelation-properties-of-gelatin-b-and-xanthan-gum-aqueous-mixtures
#2
Chang-Sheng Wang, Nick Virgilio, Paula Wood-Adams, Marie-Claude Heuzey
Gelatin B and xanthan gum aqueous mixtures (GB/XG, (0.2-2%)/0.2% w/v) exhibit enhanced gelling properties compared to their pure component solutions at similar compositions. The mixed gels comprise co-localized networks of GB and XG-rich domains. Our results show that these domains are composed of intermolecular complexes and their aggregates stabilized by the neutralization effect of GB, and linked together by formation of GB triple helices. GB/XG mixtures display composition-dependent microstructural transitions: from discontinuous aggregates (GB/XG ratio≤1) to a continuous GB/XG network (ratio=2-6), followed by network fragmentation (ratio=8-10)...
November 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28912898/inhibition-of-bone-marrow-derived-mesenchymal-stem-cells-homing-towards-triple-negative-breast-cancer-microenvironment-using-an-anti-pdgfr%C3%AE-aptamer
#3
Simona Camorani, Billy Samuel Hill, Raffaela Fontanella, Adelaide Greco, Matteo Gramanzini, Luigi Auletta, Sara Gargiulo, Sandra Albanese, Enrico Lucarelli, Laura Cerchia, Antonella Zannetti
Bone marrow-derived mesenchymal stem cells (BM-MSCs) are shown to participate in tumor progression by establishing a favorable tumor microenvironment (TME) that promote metastasis through a cytokine networks. However, the mechanism of homing and recruitment of BM-MSCs into tumors and their potential role in malignant tissue progression is poorly understood and controversial. Here we show that BM-MSCs increase aggressiveness of triple-negative breast cancer (TNBC) cell lines evaluated as capability to migrate, invade and acquire stemness markers...
2017: Theranostics
https://www.readbyqxmd.com/read/28886127/genome-wide-mirna-response-to-anacardic-acid-in-breast-cancer-cells
#4
David J Schultz, Penn Muluhngwi, Negin Alizadeh-Rad, Madelyn A Green, Eric C Rouchka, Sabine J Waigel, Carolyn M Klinge
MicroRNAs are biomarkers and potential therapeutic targets for breast cancer. Anacardic acid (AnAc) is a dietary phenolic lipid that inhibits both MCF-7 estrogen receptor α (ERα) positive and MDA-MB-231 triple negative breast cancer (TNBC) cell proliferation with IC50s of 13.5 and 35 μM, respectively. To identify potential mediators of AnAc action in breast cancer, we profiled the genome-wide microRNA transcriptome (microRNAome) in these two cell lines altered by the AnAc 24:1n5 congener. Whole genome expression profiling (RNA-seq) and subsequent network analysis in MetaCore Gene Ontology (GO) algorithm was used to characterize the biological pathways altered by AnAc...
2017: PloS One
https://www.readbyqxmd.com/read/28874908/application-of-the-intuitionistic-fuzzy-intercriteria-analysis-method-with-triples-to-a-neural-network-preprocessing-procedure
#5
Sotir Sotirov, Vassia Atanassova, Evdokia Sotirova, Lyubka Doukovska, Veselina Bureva, Deyan Mavrov, Jivko Tomov
The approach of InterCriteria Analysis (ICA) was applied for the aim of reducing the set of variables on the input of a neural network, taking into account the fact that their large number increases the number of neurons in the network, thus making them unusable for hardware implementation. Here, for the first time, with the help of the ICA method, correlations between triples of the input parameters for training of the neural networks were obtained. In this case, we use the approach of ICA for data preprocessing, which may yield reduction of the total time for training the neural networks, hence, the time for the network's processing of data and images...
2017: Computational Intelligence and Neuroscience
https://www.readbyqxmd.com/read/28869000/similarities-in-intracellular-transport-of-plant-viral-movement-proteins-bmb2-and-tgb3
#6
Ekaterina A Lazareva, Alexander A Lezzhov, Sergey A Golyshev, Sergey Y Morozov, Manfred Heinlein, Andrey G Solovyev
The cell-to-cell transport of many plant viruses through plasmodesmata requires viral movement proteins (MPs) encoded by a 'triple gene block' (TGB) and termed TGB1, TGB2 and TGB3. TGB3 is a small integral membrane protein that contains subcellular targeting signals and directs both TGB2 and the helicase domain-containing TGB1 protein to plasmodesmata-associated structures. Recently, we described a 'binary movement block' (BMB) coding for two MPs, BMB1 and BMB2. The BMB2 protein associates with endoplasmic reticulum (ER) membranes, accumulates at plasmodesmata-associated membrane bodies and directs the BMB1 helicase to these structures...
September 4, 2017: Journal of General Virology
https://www.readbyqxmd.com/read/28863519/ab-initio-potential-energy-surface-and-microwave-spectra-for-the-h2-hcccn-complex
#7
Miao Qin, Hua Zhu, Hongjun Fan
We present a four-dimensional ab initio potential energy surface of the H2-HCCCN complex at the coupled-cluster singles and doubles with noniterative inclusion of connected triples [CCSD(T)]-F12 level with a large basis set including an additional set of bond functions. The artificial neural networks method was extended to fit the intermolecular potential energy surface. The complex has a planar linear global minimum with the well depth of 199.366 cm(-1) located at R = 5.09 Å, φ = 0°, θ1 = 0°, and θ2 = 180°...
August 28, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28854386/first-principles-computational-study-on-hydrolysis-of-hazardous-chemicals-phosphorus-trichloride-and-oxychloride-pcl3-and-pocl3-catalyzed-by-molecular-water-clusters
#8
Hyunwook Jung, Joonhee Kang, Hoje Chun, Byungchan Han
Using first principles calculations we unveil fundamental mechanism of hydrolysis reactions of two hazardous chemicals PCl3 and POCl3 with explicit molecular water clusters nearby. It is found that the water molecules play a key role as a catalyst significantly lowing activation barrier of the hydrolysis via transferring its protons to reaction intermediates. Interestingly, torsional angle of the molecular complex at transition state is identified as a vital descriptor on the reaction rate. Analysis of charge distribution over the complex further reinforces the finding with atomic level correlation between the torsional angle and variation of the orbital hybridization state of phosphorus (P) in the complex...
August 24, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28845540/building-collagen-iv-smart-scaffolds-on-the-outside-of-cells
#9
REVIEW
Kyle L Brown, Christopher F Cummings, Roberto Vanacore, Billy Hudson
Collagen IV scaffolds assemble through an intricate pathway that begins intracellularly and is completed extracellularly. Multiple intracellular enzymes act in concert to assemble collagen IV protomers, the building blocks of collagen IV scaffolds. After being secreted from cells, protomers are activated to initiate oligomerization, forming insoluble networks that are structurally reinforced with covalent crosslinks. Within these networks, embedded binding sites along the length of the protomer lead to the "decoration" of collagen IV triple helix with numerous functional molecules...
August 28, 2017: Protein Science: a Publication of the Protein Society
https://www.readbyqxmd.com/read/28795861/lnc00673-errlr01-is-a-prognostic-indicator-of-overall-survival-in-breast-cancer
#10
Ubaidat Abdul-Rahman, Balázs Gyoörffy, Brian D Adams
LncRNAs are novel noncoding RNAs involved in the epigenetic regulation of gene expression by recruiting ribonucleoprotein complexes to specific genomic loci to initiate histone methylation and/or other chromatin modifications. LncRNAs themselves function as tumor suppressors or oncogenes, depending on the gene regulatory networks they govern. We identified lnc00673 (ERRLR01) as a marker of overall survival (OS) in breast cancer patients. Specifically, ERRLR01 levels were elevated in triple-negative breast cancer (TNBC) as compared to Luminal- A, Luminal-B, and HER2 breast cancer subtypes...
August 10, 2017: Transcription
https://www.readbyqxmd.com/read/28790178/heteromeric-channels-formed-by-trpc1-trpc4-and-trpc5-define-hippocampal-synaptic-transmission-and-working-memory
#11
Jenny Bröker-Lai, Astrid Kollewe, Barbara Schindeldecker, Jörg Pohle, Vivan Nguyen Chi, Ilka Mathar, Raul Guzman, Yvonne Schwarz, Alan Lai, Petra Weißgerber, Herbert Schwegler, Alexander Dietrich, Martin Both, Rolf Sprengel, Andreas Draguhn, Georg Köhr, Bernd Fakler, Veit Flockerzi, Dieter Bruns, Marc Freichel
Canonical transient receptor potential (TRPC) channels influence various neuronal functions. Using quantitative high-resolution mass spectrometry, we demonstrate that TRPC1, TRPC4, and TRPC5 assemble into heteromultimers with each other, but not with other TRP family members in the mouse brain and hippocampus. In hippocampal neurons from Trpc1/Trpc4/Trpc5-triple-knockout (Trpc1/4/5(-/-)) mice, lacking any TRPC1-, TRPC4-, or TRPC5-containing channels, action potential-triggered excitatory postsynaptic currents (EPSCs) were significantly reduced, whereas frequency, amplitude, and kinetics of quantal miniature EPSC signaling remained unchanged...
September 15, 2017: EMBO Journal
https://www.readbyqxmd.com/read/28782521/mpk-1-erk-regulatory-network-controls-the-number-of-sperm-by-regulating-timing-of-sperm-oocyte-switch-in-c-%C3%A2-elegans-germline
#12
Dong Suk Yoon, Mohammad A Alfhili, Kyle Friend, Myon-Hee Lee
The precise regulation of germline sexual fate is crucial for animal fertility. In C. elegans, the production of either type of gamete, sperm or oocyte, becomes mutually exclusive beyond the larval stage. Hermaphrodites initially produce sperm and then switch to produce oocytes. This change of fate during germline development is tightly controlled by several regulators. In C. elegans hermaphrodites, FBF-1 and FBF-2 (>95% identical, members of the Pumilio RNA-binding protein family) proteins function redundantly to promote the sperm-oocyte switch...
September 30, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28773959/metal-promoted-assembly-of-two-collagen-mimetic-peptides-into-a-biofunctional-spiraled-horn-scaffold
#13
Kevin Strauss, Jean Chmielewski
Biofunctional scaffolds for the delivery of living cells are of the utmost importance for regenerative medicine. Herein, a novel, robust "spiraled horn" scaffold was elucidated through the Co(2+)-promoted hierarchical assembly of two collagen mimetic peptides, NCoH and HisCol. Each "horn" displayed a periodic banding pattern with band lengths corresponding to the length of the collagen peptide triple helix. Strand exchange between the two peptide trimers resulted in failure to form this intricate morphology, lending support to a precise metal-ligand-based mechanism of assembly...
October 17, 2016: Materials
https://www.readbyqxmd.com/read/28758713/in-situ-assembly-of-au-nanoclusters-within-protein-hydrogel-networks
#14
Liqiang Wang, Xingxing Jiang, Min Zhang, Minghui Yang, You-Nian Liu
We report a new approach of in situ assembling gold nanoclusters (AuNCs) into hydrogel networks by exploiting the triple roles of protein as a gelator, a reducing agent as well as a template. The strategy simply involves the mixing of BSA and AuCl4(-) under alkaline condition. The obtained AuNCs-protein nanocomposite hydrogels with injectable and moldable features can be made into semi-transparent films or N-doped C/Au composites. Our work demonstrates the feasibility of fabricating AuNCs in situ embedded in hybrid hydrogels, which can serve as multifunctional precursors for constructing diverse nanocomposite materials...
July 31, 2017: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/28756109/altered-coupling-of-default-mode-executive-control-and-salience-networks-in-internet-gaming-disorder
#15
J T Zhang, S-S Ma, C-G Yan, S Zhang, L Liu, L-J Wang, B Liu, Y-W Yao, Y-H Yang, X-Y Fang
BACKGROUND: Recently, a triple-network model suggested the abnormal interactions between the executive-control network (ECN), default-mode network (DMN) and salience network (SN) are important characteristics of addiction, in which the SN plays a critical role in allocating attentional resources toward the ECN and DMN. Although increasing studies have reported dysfunctions in these brain networks in Internet gaming disorder (IGD), interactions between these networks, particularly in the context of the triple-network model, have not been investigated in IGD...
July 12, 2017: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/28743059/altered-connectivity-within-and-between-the-default-mode-central-executive-and-salience-networks-in-obsessive-compulsive-disorder
#16
Jie Fan, Mingtian Zhong, Jun Gan, Wanting Liu, Chaoyang Niu, Haiyan Liao, Hongchun Zhang, Jinyao Yi, Raymond C K Chan, Changlian Tan, Xiongzhao Zhu
BACKGROUND: Default mode network (DMN), central executive network (CEN) and salience network (SN) are the three most important intrinsic networks of the human brain. Recent studies emphasized the importance of the "triple-network model" which illustrated the interactions within and between DMN, CEN and SN in the pathophysiology of psychiatric disorders. However, previous studies of obsessive-compulsive disorder (OCD) just explored the altered connectivity within these networks while neglected the coupling between them...
July 20, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28739740/global-analysis-of-mirna-mrna-interaction-network-in-breast-cancer-with-brain-metastasis
#17
Zhixin Li, Zhiqiang Peng, Siyu Gu, Junfang Zheng, Duiping Feng, Qiong Qin, Junqi He
BACKGROUND: MicroRNAs (miRNAs) have been linked to a number of cancer types including breast cancer. The rate of brain metastases is 10-30% in patients with advanced breast cancer which is associated with poor prognosis. The potential application of miRNAs in the diagnostics and therapeutics of breast cancer with brain metastasis is an area of intense interest. In an initial effort to systematically address the differential expression of miRNAs and mRNAs in primary breast cancer which may provide clues for early detection of brain metastasis, we analyzed the consequent changes in global patterns of gene expression in Gene Expression Omnibus (GEO) data set obtained by microarray from patients with in situ carcinoma and patients with brain metastasis...
August 2017: Anticancer Research
https://www.readbyqxmd.com/read/28735027/translation-of-an-injectable-triple-interpenetrating-network-hydrogel-for-intervertebral-disc-regeneration-in-a-goat-model
#18
Sarah E Gullbrand, Thomas P Schaer, Prateek Agarwal, Justin R Bendigo, George R Dodge, Weiliam Chen, Dawn M Elliott, Robert L Mauck, Neil R Malhotra, Lachlan J Smith
Degeneration of the intervertebral discs is a progressive cascade of cellular, compositional and structural changes that is frequently associated with low back pain. As the first signs of disc degeneration typically arise in the disc's central nucleus pulposus (NP), augmentation of the NP via hydrogel injection represents a promising strategy to treat early to mid-stage degeneration. The purpose of this study was to establish the translational feasibility of a triple interpenetrating network hydrogel composed of dextran, chitosan, and teleostean (DCT) for augmentation of the degenerative NP in a preclinical goat model...
September 15, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28723663/a-network-meta-analysis-on-the-efficacy-of-targeted-agents-in-combination-with-chemotherapy-for-treatment-of-advanced-metastatic-triple-negative-breast-cancer
#19
Long Ge, Yan Tang, Qiu-Ning Zhang, Jin-Hui Tian, Xiao-Hu Wang, Dawid Pieper, Bei Pan, Lun Li, Juan Ling, Zhi-Tong Bing, Ke-Hu Yang
OBJECTIVE: Our network meta-analysis aimed to determine the assistant efficacy of targeted therapy in combined with chemotherapy for advanced/metastatic triple-negative breast cancer (TNBC). RESULTS: A total of 15 randomized controlled trials (RCTs), involving 2,410 patients, met our inclusion criteria. Eight targeted agents involving 11 treatment arms were included. The methodological quality of included RCTs was acceptable. The results of direct comparisons showed that progression-free survival (PFS) was significantly longer with bevacizumab+chemotherapy when compared to chemotherapy alone (hazard ratio [HR] = 0...
July 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28722702/radiofrequency-ablation-of-hepatic-tumor-subjective-assessment-of-the-perilesional-vascular-network-on-contrast-enhanced-computed-tomography-before-and-after-ablation-can-reliably-predict-the-risk-of-local-recurrence
#20
Sireesha Yedururi, Silanath Terpenning, Sanjay Gupta, Patricia Fox, Sooyoung Shin Martin, Claudius Conrad, Evelyne M Loyer
OBJECTIVE: To determine whether simple, subjective analysis of the perilesional vascular network can predict the risk of local recurrence after radiofrequency ablation (RFA) of liver malignancies on contrast-enhanced computed tomography (CECT). METHODS: Contrast-enhanced computed tomography's 103 patients (59 men and 44 women; mean age, 63 years (range, 31-84 years) with 134 lesions who underwent RFA between 2000 and 2010 were retrospectively analyzed. The primary tumors include colorectal carcinoma (58 patients), hepatocellular carcinoma (n = 13), breast carcinoma (n = 8), neuroendocrine tumor (n = 5), and others (n = 19)...
July 2017: Journal of Computer Assisted Tomography
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