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novel biomarkers in coronary heart disease

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https://www.readbyqxmd.com/read/28071727/plasma-amino-acid-profile-in-patients-with-aortic-dissection
#1
Linlin Wang, Sha Liu, Wengang Yang, Haitao Yu, Li Zhang, Ping Ma, Peng Wu, Xue Li, Kenka Cho, Song Xue, Baohong Jiang
Aortic dissection (AD), a severe cardiovascular disease with the characteristics of high mortality, is lack of specific clinical biomarkers. In order to facilitate the diagnosis of AD, we investigated plasma amino acid profile through metabolomics approach. Total 33 human subjects were enrolled in the study: 11 coronary heart disease (CHD) patients without aortic lesion and 11 acute AD and 11 chronic AD. Amino acids were identified in plasma using liquid chromatography and mass spectrometry (LC-MS/MS), and were further subjected to multiple logistic regression analysis...
January 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28057184/advances-in-cardiac-biomarkers-of-acute-coronary-syndrome
#2
A K Saenger, N Korpi-Steiner
Acute coronary syndrome (ACS) encompasses a pathophysiological spectrum of cardiovascular diseases, all of which have significant morbidity and mortality. ACS was once considered an acute condition; however, new treatment strategies and improvements in biomarker assays have led to ACS being an acute and chronic disease. Cardiac troponin is the preferred biomarker for the diagnosis of myocardial infarction, and there is considerable interest and efforts toward development and implementation of high-sensitivity cardiac troponin (hs-cTn) assays worldwide...
2017: Advances in Clinical Chemistry
https://www.readbyqxmd.com/read/28053922/adropin-a-novel-biomarker-of-heart-disease-a-systematic-review-article
#3
REVIEW
Somaye Yosaee, Sepideh Soltani, Eghbal Sekhavati, Shima Jazayeri
BACKGROUND: Heart disease is one of the most common chronic disease and leading cause of morbidity and mortality worldwide. Adropin, a newly identified protein, is important for energy homeostasis and maintaining insulin sensitivity, and has been referred to as a novel regulator of endothelial cells. Endothelial dysfunction is a key early event in atherogenesis and onset of HD. Therefore, this review gives a systematic overview of studies investigating plasma adropin level in patient with heart disease...
December 2016: Iranian Journal of Public Health
https://www.readbyqxmd.com/read/27942693/the-integrated-effect-of-moderate-exercise-on-coronary-heart-disease
#4
REVIEW
Marc J Mathews, Edward H Mathews, George E Mathews
BACKGROUND: Moderate exercise is associated with a lower risk for coronary heart disease (CHD). A suitable integrated model of the CHD pathogenetic pathways relevant to moderate exercise may help to elucidate this association. Such a model is currently not available in the literature. METHODS: An integrated model of CHD was developed and used to investigate pathogenetic pathways of importance between exercise and CHD. Using biomarker relative-risk data, the pathogenetic effects are representable as measurable effects based on changes in biomarkers...
December 12, 2016: Cardiovascular Journal of Africa
https://www.readbyqxmd.com/read/27915085/monocyte-derived-circulating-microparticles-cd14-cd14-cd11b-and-cd14-cd142-are-related-to-long-term-prognosis-for-cardiovascular-mortality-in-stemi-patients
#5
Gemma Chiva-Blanch, Vibeke Bratseth, Vibeke Ritschel, Geir Ø Andersen, Sigrun Halvorsen, Jan Eritsland, Harald Arnesen, Lina Badimon, Ingebjørg Seljeflot
BACKGROUND: Circulating microparticles (cMPs) have been proposed as novel biomarkers of cardiovascular disease (CVD). We aimed to investigate the prognostic relevance of cMPs for future major adverse cardiovascular events (MACE) in STEMI patients. METHODS: We included 200 STEMI patients treated with percutaneous coronary intervention (PCI). One hundred patients with a primary composite end point (recurrent nonfatal acute MI, rehospitalization for heart failure, unscheduled PCI or death because of CV causes) were case-matched for sex, age, and CVD risk factors to 100 patients without a primary endpoint at the end of study follow-up (4...
January 15, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/27882321/micrornas-in-coronary-heart-disease-ready-to-enter-the-clinical-arena
#6
REVIEW
Elena Cavarretta, Giacomo Frati
Coronary artery disease (CAD) and its complication remain the leading cause of mortality in industrialized countries despite great advances in terms of diagnosis, prognosis, and treatment options. MicroRNAs (miRNAs), small noncoding RNAs, act as posttranscriptional gene expression modulators and have been implicated as key regulators in several physiological and pathological processes linked to CAD. Circulating miRNAs have been evaluated as promising novel biomarkers of CAD, acute coronary syndromes, and acute myocardial infarction, with prognostic implications...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27846870/oral-health-and-coronary-heart-disease
#7
Marc J Mathews, Edward H Mathews, George E Mathews
BACKGROUND: It is well documented that there is some correlation between poor oral health in the form of periodontal disease and coronary heart disease (CHD). It is unclear whether this correlation is due to a causal relationship or shared underlying disorder such as inflammation. A suitable integrated model of the CHD pathogenetic pathways relevant to periodontal disease may help to elucidate the association. Such a model is currently not available in literature. METHODS: A previously developed integrated model of CHD was used to investigate potential pathogenetic pathways linking periodontal disease to CHD biomarkers...
November 15, 2016: BMC Oral Health
https://www.readbyqxmd.com/read/27814596/diagnosis-of-cardiac-allograft-vasculopathy-challenges-and-opportunities
#8
Bhavesh Patel, Aashish Ahuja, Ghassan S Kassab, Carlos A Labarrere
Cardiac allograft vasculopathy (CAV) is one of the most common long-term complications in patients following heart transplantation. Because of its irreversible nature, early detection is essential to impact progression. Thus, imaging techniques play a crucial role in the diagnosis and subsequent treatment. Major advancements in imaging and analysis are required to overcome the limitations of current techniques. Coronary angiography which is the standard method, presents low sensitivity in detection, especially at an early stage...
January 1, 2017: Frontiers in Bioscience (Elite Edition)
https://www.readbyqxmd.com/read/27811210/a-novel-protein-glycan-derived-inflammation-biomarker-independently-predicts-cardiovascular-disease-and-modifies-the-association-of-hdl-subclasses-with-mortality
#9
Robert W McGarrah, Jacob P Kelly, Damian M Craig, Carol Haynes, Ryan C Jessee, Kim M Huffman, William E Kraus, Svati H Shah
BACKGROUND: Evidence suggests that systemic inflammation may adversely impact HDL function. In this study we sought to evaluate the independent and incremental predictive performance of GlycA-a novel serum inflammatory biomarker that is an aggregate measure of enzymatically glycosylated acute phase proteins-and HDL subclasses on adverse events in a retrospective observational study of a secondary prevention population and to understand a priori defined potential interactions between GlycA and HDL subclasses...
January 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/27803933/endothelial-microparticles-act-as-novel-diagnostic-and-therapeutic-biomarkers-of-diabetes-and-its-complications-a-literature-review
#10
REVIEW
Fan Deng, Shuang Wang, Liangqing Zhang
Diabetes mellitus- (DM-) related vascular diseases attract increased attention due to their high morbidity and mortality. The incidence of obesity, atherosclerosis, coronary heart disease, hypertension, and dyslipidemia is significantly higher in DM patients, with an earlier onset and faster progression compared with non-DM patients. DM-related vascular diseases including macrovascular and microvascular complications are characterized by endothelial dysfunction. Therefore, a better understanding of the etiology and mechanisms of endothelial dysfunction is important for the diagnosis and treatment of DM...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27784010/clinical-application-of-biomarkers-in-heart-failure-with-a-preserved-ejection-fraction-a-review
#11
Aakash Garg, Deepti Virmani, Sahil Agrawal, Chirag Agarwal, Abhishek Sharma, Giulio Stefanini, John B Kostis
Heart failure with a preserved ejection fraction (HFpEF) is increasingly prevalent and a leading cause of morbidity and mortality worldwide. HFpEF has a complex pathophysiology, with recent evidence suggesting that an interaction of cardiovascular and noncardiovascular comorbidities (e.g. obesity, hypertension, diabetes, coronary artery disease, and chronic kidney disease) induces an inflammatory state that eventually leads to myocardial structural and functional alterations. Current ACCF/AHA guidelines suggest incorporation of biomarkers along with clinical and imaging tools to establish the diagnosis and disease severity in heart failure (HF)...
October 27, 2016: Cardiology
https://www.readbyqxmd.com/read/27713999/an-lc-ms-based-untargeted-metabolomics-study-identified-novel-biomarkers-for-coronary-heart-disease
#12
Ruijun Li, Fengyu Li, Qiang Feng, Zhipeng Liu, Zhuye Jie, Bo Wen, Xun Xu, Shilong Zhong, Guanglei Li, Kunlun He
This study performed untargeted metabolomics for plasma samples from 40 coronary heart disease patients and 43 healthy controls by high-performance liquid chromatography coupled with mass spectrometry technology to find a set of effective biomarkers for CHD diagnosis and prognosis. The discriminating metabolites were extracted and analyzed by univariate and multivariate analysis methods. We found five metabolites (1-naphthol, 2-naphthol, methylitaconate, N-acetyl-d-glucosamine 6-phosphate and l-carnitine) contributing to the separation of CHD patients from healthy controls, and a subset of two metabolites in these five were identified as potential plasma biomarkers for CHD diagnosis...
October 18, 2016: Molecular BioSystems
https://www.readbyqxmd.com/read/27553421/serum-levels-of-mitochondrial-inhibitory-factor-1-are-independently-associated-with-long-term-prognosis-in-coronary-artery-disease-the-genes-study
#13
Annelise Genoux, Laeticia Lichtenstein, Jean Ferrières, Thibaut Duparc, Vanina Bongard, Paul-Louis Vervueren, Guillaume Combes, Dorota Taraszkiewicz, Meyer Elbaz, Michel Galinier, Bertrand Nassar, Jean-Bernard Ruidavets, Bertrand Perret, Laurent O Martinez
BACKGROUND: Epidemiological and observational studies have established that high-density lipoprotein cholesterol (HDL-C) is an independent negative cardiovascular risk factor. However, simple measurement of HDL-C levels is no longer sufficient for cardiovascular risk assessment. Therefore, there is a critical need for novel non-invasive biomarkers that would display prognostic superiority over HDL-C. Cell surface ecto-F1-ATPase contributes to several athero-protective properties of HDL, including reverse cholesterol transport and vascular endothelial protection...
August 23, 2016: BMC Medicine
https://www.readbyqxmd.com/read/27540030/prognostic-utility-of-galectin-3-for-recurrent-cardiovascular-events-during-long-term-follow-up-in-patients-with-stable-coronary-heart-disease-results-of-the-karola-study
#14
Henning Jansen, Wolfgang Koenig, Andrea Jaensch, Ute Mons, Lutz P Breitling, Hubert Scharnagl, Tatjana Stojakovic, Heribert Schunkert, Hermann Brenner, Dietrich Rothenbacher
BACKGROUND: Galectin-3 has emerged as a potential useful novel biomarker for heart failure and cardiovascular disease (CVD). However, it remains unclear whether galectin-3 is associated with recurrent cardiovascular events during long-term follow-up of patients with stable coronary heart disease (CHD) after adjustment for multiple established and novel risk factors. METHODS: We measured galectin-3 at baseline in a cohort consisting of 1035 CHD patients and followed them for 13 years to assess a combined CVD end point...
October 2016: Clinical Chemistry
https://www.readbyqxmd.com/read/27459447/psychiatric-psychological-and-social-determinants-of-health-in-the-nurses-health-study-cohorts
#15
Claudia Trudel-Fitzgerald, Ying Chen, Ankura Singh, Olivia I Okereke, Laura D Kubzansky
OBJECTIVES: To review the contribution of the Nurses' Health Studies (NHS) on factors that influence mental and physical health. METHODS: Narrative review of all published articles using data from the NHS, the NHS II, and the Growing Up Today Study focusing on mental health conditions (e.g., depression, posttraumatic stress disorder, anxiety) and psychosocial resources and stressors (e.g., job strain, interpersonal violence, social relationships, sexual orientation) between 1990 and 2016...
September 2016: American Journal of Public Health
https://www.readbyqxmd.com/read/27429122/identification-of-novel-biomarker-candidates-for-hypertrophic-cardiomyopathy-and-other-cardiovascular-diseases-leading-to-heart-failure
#16
H Rehulkova, P Rehulka, A Myslivcova Fucikova, J Stulik, R Pudil
In-depth proteome discovery analysis represents new strategy in an effort to identify novel reliable specific protein markers for hypertrophic cardiomyopathy and other life threatening cardiovascular diseases. To systematically identify novel protein biomarkers of cardiovascular diseases with high mortality we employed an isobaric tag for relative and absolute quantitation (iTRAQ) proteome technology to make comparative analysis of plasma samples obtained from patients suffering from non-obstructive hypertrophic cardiomyopathy, stable dilated cardiomyopathy, aortic valve stenosis, chronic stable coronary artery disease and stable arterial hypertension...
November 23, 2016: Physiological Research
https://www.readbyqxmd.com/read/27374153/circulating-mir-221-3p-as-a-novel-marker-for-early-prediction-of-acute-myocardial-infarction
#17
Ender Coskunpinar, Huseyin Altug Cakmak, Ali Kemal Kalkan, Necip Ozan Tiryakioglu, Mehmet Erturk, Zeki Ongen
Recent studies have reported circulating microRNAs (miRNAs) as novel biomarkers for cardiovascular diseases including acute myocardial infarction, heart failure, diabetes mellitus, stroke, and acute pulmonary embolism. The aims of this study were 1) to compare the plasma expression levels of miRNAs in patients with acute coronary syndrome (ACS) and control subjects and in ST-elevation myocardial infarction (STEMI) and non-STEMI 2) to evaluate miRNAs potential to be used as novel diagnostic biomarkers for ACS...
October 10, 2016: Gene
https://www.readbyqxmd.com/read/27279347/a-systems-biology-and-proteomics-based-approach-identifies-src-and-vegfa-as-biomarkers-in-risk-factor-mediated-coronary-heart-disease
#18
Alexandar V, Pradeep G Nayar, R Murugesan, Shajahan S, Jayalakshmi Krishnan, Shiek S S J Ahmed
Coronary heart disease (CHD) is the most common cause of death worldwide. The burden of CHD increases with risk factors such as smoking, hypertension, obesity and diabetes. Several studies have demonstrated the association of these classical risk factors with CHD. However, the mechanisms of these associations remain largely unclear due to the complexity of disease pathophysiology and the lack of an integrative approach that fails to provide a definite understanding of molecular linkage. To overcome these problems, we propose a novel systems biology approach that relates causative genes, interactomes and pathways to elucidate the risk factors mediating the molecular mechanisms and biomarkers for feasible diagnosis...
July 19, 2016: Molecular BioSystems
https://www.readbyqxmd.com/read/27212662/subjective-well-being-and-cardiometabolic-health-an-8-11year-study-of-midlife-adults
#19
Julia K Boehm, Ying Chen, David R Williams, Carol D Ryff, Laura D Kubzansky
OBJECTIVE: Individuals who are satisfied and experience frequent positive emotions tend to have reduced risk for coronary heart disease (CHD). However, conflicting evidence exists and little research has investigated whether well-being is associated with early-warning indicators of biological risk that precede CHD. We investigated whether life satisfaction and positive emotions longitudinally predicted reduced risk of incident cardiometabolic conditions and healthier cardiometabolic risk scores, which may provide insight into underlying mechanisms and novel prevention targets...
June 2016: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/27126396/cardiovascular-risk-stratification-in-familial-hypercholesterolaemia
#20
REVIEW
Mahtab Sharifi, Roby D Rakhit, Steve E Humphries, Devaki Nair
Familial hypercholesterolaemia (FH) is a common autosomal-dominant disorder in most European countries. Patients with FH are characterised by a raised level of low-density lipoprotein cholesterol and a high risk of premature coronary heart disease (CHD). Currently there is no consensus regarding the clinical utility to predict future coronary events or testing for the presence of subclinical atherosclerotic disease in asymptomatic patients with FH. Family screening of patients with FH as recommended by the UK National Institute of Health and Care Excellence guideline would result in finding many young individuals with a diagnosis of FH who are clinically asymptomatic...
July 1, 2016: Heart: Official Journal of the British Cardiac Society
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