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miRNA T cell

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https://www.readbyqxmd.com/read/29666503/regulatory-t-cell-derived-extracellular-vesicles-modify-dendritic-cell-function
#1
Sim L Tung, Dominic A Boardman, Monica Sen, Marilena Letizia, Qi Peng, Nicole Cianci, Laura Dioni, Leo M Carlin, Robert Lechler, Valentina Bollati, Giovanna Lombardi, Lesley A Smyth
Regulatory T cells (Treg) are a subpopulation of T cells that maintain tolerance to self and limit other immune responses. They achieve this through different mechanisms including the release of extracellular vesicles (EVs) such as exosomes as shown by us, and others. One of the ways that Treg derived EVs inhibit target cells such as effector T cells is via the transfer of miRNA. Another key target for the immunoregulatory function of Tregs is the dendritic cells (DCs). In this study we demonstrate directly, and for the first time, that miRNAs are transferred from Tregs to DCs via Treg derived EVs...
April 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29662198/the-mir-106b-25-cluster-mediates-breast-tumor-initiation-through-activation-of-notch1-via-direct-repression-of-nedd4l
#2
A L Guarnieri, C G Towers, D J Drasin, M U J Oliphant, Z Andrysik, T J Hotz, R L Vartuli, E S Linklater, A Pandey, S Khanal, J M Espinosa, H L Ford
Tumor-initiating cells (TIC) represent a subset of tumor cells with increased self-renewal capability. TICs display resistance to frontline cancer treatment and retain the ability to repopulate a tumor after therapy, leading to cancer relapse. NOTCH signaling has been identified as an important driver of the TIC population, yet mechanisms governing regulation of this pathway in cancer remain to be fully elucidated. Here we identify a novel mechanism of NOTCH regulation and TIC induction in breast cancer via the miR-106b-25 miRNA cluster...
April 17, 2018: Oncogene
https://www.readbyqxmd.com/read/29661539/mir-548k-regulates-cxcl13-expression-in-myasthenia-gravis-patients-with-thymic-hyperplasia-and-in-jurkat-cells
#3
Jinpin Li, Di Qiu, Zezhi Chen, Weiwei Du, Jingli Liu, Xuean Mo
Myasthenia gravis (MG) is a B cell-mediated and T cell-dependent autoimmune disease. Thymic hyperplasia has great significance for MG pathogenesis and treatment. MicroRNAs (miRNAs) are a newly recognized type of gene expression regulatory factor that regulate gene expression at the post-transcriptional level. Additionally, miRNAs are involved in immune regulation of the thymus and the occurrence and development of autoimmune diseases. In this study, we found 33 miRNAs that were significantly dysregulated in thymic tissues from MG patients with thymus hyperplasia (MGH) compared with thymic tissues from normal controls using a miRNA microarray chip...
April 4, 2018: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/29644860/up-regulation-of-t-cell-activation-micrornas-in-drug-specific-cd4-t-cells-from-hypersensitive-patients
#4
Alejandra Monroy-Arreola, Noe Duran-Figueroa, Silvia Mendez-Flores, Judith Dominguez-Cherit, Joel Watkinson, Agustin Badillo-Corona, Paul Whitaker, Dean Naisbitt, Luis Castrejon Flores
Dysregulation in the expression of microRNAs (miRNAs), single stranded RNAs which regulate gene expression, has been associated with diseases such as Stevens-Johnson syndrome (SJS) / toxic epidermal necrolysis (TEN), although their cellular origin has not been explored. Thus, the focus of this work was to study expression patterns of reported miRNAs involved in T - cell activation following drug-specific stimulation in peripheral blood mononuclear cells (PBMCs) and drug specific CD4+ T-cell clones (TCC) from patients with different cutaneous manifestations of delayed-type drug hypersensitivity reactions...
April 12, 2018: Chemical Research in Toxicology
https://www.readbyqxmd.com/read/29629073/construction-of-an-autonomously-concatenated-hybridization-chain-reaction-for-signal-amplification-and-intracellular-imaging
#5
Jie Wei, Xue Gong, Qing Wang, Min Pan, Xiaoqing Liu, Jing Liu, Fan Xia, Fuan Wang
Biomolecular self-assembly has spurred substantial research efforts for the development of low-cost point-of-care diagnostics. Herein, we introduce an isothermal enzyme-free concatenated hybridization chain reaction (C-HCR), in which the output of the upstream hybridization chain reaction (HCR-1) layer acts as an intermediate input to activate the downstream hybridization chain reaction (HCR-2) layer. The initiator motivates HCR-1 through the autonomous cross-opening of two functional DNA hairpins, yielding polymeric dsDNA nanowires composed of numerous tandem triggers T as output of the primary sensing event...
January 7, 2018: Chemical Science
https://www.readbyqxmd.com/read/29625070/a-clk3-hmga2-alternative-splicing-axis-impacts-human-hematopoietic-stem-cell-molecular-identity-throughout-development
#6
Marcella Cesana, Michael H Guo, Davide Cacchiarelli, Lara Wahlster, Jessica Barragan, Sergei Doulatov, Linda T Vo, Beatrice Salvatori, Cole Trapnell, Kendell Clement, Patrick Cahan, Kaloyan M Tsanov, Patricia M Sousa, Barbara Tazon-Vega, Adriano Bolondi, Federico M Giorgi, Andrea Califano, John L Rinn, Alexander Meissner, Joel N Hirschhorn, George Q Daley
While gene expression dynamics have been extensively cataloged during hematopoietic differentiation in the adult, less is known about transcriptome diversity of human hematopoietic stem cells (HSCs) during development. To characterize transcriptional and post-transcriptional changes in HSCs during development, we leveraged high-throughput genomic approaches to profile miRNAs, lincRNAs, and mRNAs. Our findings indicate that HSCs manifest distinct alternative splicing patterns in key hematopoietic regulators...
April 5, 2018: Cell Stem Cell
https://www.readbyqxmd.com/read/29621782/enhanced-pro-inflammatory-response-of-macrophages-to-interleukin-33-in-an-allergic-environment
#7
Noel Chia, Rakesh K Kumar, Paul S Foster, Cristan Herbert
BACKGROUND: Allergic asthma is common in childhood and is associated with a T-helper type 2 (Th2)-biased immunological response. Exacerbations of asthma are characterised by increased inflammation of the airways, which appears to be driven by interleukin (IL)-33 that can activate pulmonary macrophages. The Th2 cytokine environment of allergic asthma may contribute to exaggerated airway inflammation. OBJECTIVES: To test this, we assessed whether production of pro-inflammatory cytokines by IL-33-stimulated macrophages was enhanced in cells pre-treated with the key Th2 cytokines IL-4 and IL-13...
April 5, 2018: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/29620289/function-of-microrna%C3%A2-141-in-human-breast-cancer-through-cytotoxic-cd4-t-cells-regulated-by-map4k4-expression
#8
Qing Zhang, Huang Xin, Tang Fen
The present study investigated the anti‑cancer effect of microRNA (miRNA)‑141 on apoptosis rate of breast cancer cells and the possible underlying mechanism. In patients with breast cancer, the expression of miRNA‑141 was downregulated. Overexpression of miRNA‑141 reduced breast cancer cell growth, inhibited the expression of cyclooxygenase‑2 (COX‑2), prostaglandin E2 (PGE2) and tumor necrosis factor (TNF)‑α, and increased the expression levels of interleukin (IL)‑10. However, downregulation of miRNA‑141 resulted in upregulation of COX‑2, PGE2 and TNF‑α expression levels, and an inhibition of IL‑10...
March 28, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29618717/the-profiles-and-networks-of-mirna-lncrna-mrna-and-circrna-in-benzo-a-pyrene-transformed-bronchial-epithelial-cells
#9
Xinhang Jiang, Xiaoying Wu, Feiyu Chen, Wei He, Xintong Chen, Linhua Liu, Huanwen Tang
Our aim was to demonstrate the significance of miRNA, lncRNA, and circRNA in the transformation of human bronchial epithelial cells induced by benzo(a)pyrene (BaP), and to investigate their regulatory networks. Hierarchical clustering, gene ontology (GO) analysis, Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis and network regulation analysis were used to analyze the high-throughput sequencing results of human bronchial epithelial cell line BEAS-2B and BaP-transformed BEAS-2B cells (BEAS-2B-T). 76,191,786 and 3,431differentially-expressed miRNA, lncRNA, mRNA and circRNA were detected, respectively; 43 miRNA, 48 lncRNA, 438 mRNA and 2,079 circRNA were up-regulated; 33 miRNA, 143 lncRNA, 348 mRNA and 1,352 circRNA were down-regulated...
2018: Journal of Toxicological Sciences
https://www.readbyqxmd.com/read/29617044/pcsk9-plays-a-novel-immunological-role-in-the-oxidized-ldl-induced-dendritic-cell-maturation-and-t-cell-activation-from-human-blood-and-atherosclerotic-plaque
#10
Anquan Liu, Johan Frostegård
BACKGROUND: Activated T cells and dendritic cells (DCs) occur in atherosclerotic plaques. Proprotein convertase subtilisin kexin 9 (PCSK9) targets the LDL-receptor (LDLR), and results in increased LDL-levels. We here investigate immune effects of PCSK9 on OxLDL induced DC maturation and T cell activation. METHODS: T cells were isolated from carotid specimens of patients undergoing carotid endarterectomy, or from peripheral blood of healthy individuals. Human peripheral blood monocytes were differentiated into DCs...
April 4, 2018: Journal of Internal Medicine
https://www.readbyqxmd.com/read/29611713/effects-of-thymoquinone-on-liver-mirnas-and-oxidative-stress-in-ehrlich-acid-mouse-solid-tumor-model
#11
I Meral, M Pala, F Akbas, S Ustunova, C Yildiz, M H Demirel
We investigated the effects of thymoquinone (TQ) on the expression of liver microRNAs (miRNAs), liver histopathology and oxidative stress in Ehrlich acid solid tumor model induced mice. We used 24 male BALB/c mice divided randomly into three groups. Control (C) group mice were injected intraperitoneally (i.p.) with 0.5 ml saline for four weeks. Tumor (T) group mice were injected i.p. with 0.5 ml saline for four weeks, then Ehrlich acid tumor cells were injected subcutaneously into the neck to induce solid tumor formation...
April 3, 2018: Biotechnic & Histochemistry: Official Publication of the Biological Stain Commission
https://www.readbyqxmd.com/read/29605406/micro-rna-profile-and-proteins-in-peritoneal-fluid-from-women-with-endometriosis-their-relationship-with-sterility
#12
Josep Marí-Alexandre, Moisés Barceló-Molina, Elisa Belmonte-López, Javier García-Oms, Amparo Estellés, Aitana Braza-Boïls, Juan Gilabert-Estellés
OBJECTIVE: To define the microRNA (miRNA) profile and its relationship with cytokines content in peritoneal fluid (PF) from endometriosis patients. DESIGN: Case-control study. SETTING: University hospital, research institute. PATIENT(S): One hundred twenty-six women with endometriosis (EPF) and 45 control women (CPF). MAIN OUTCOMES MEASURE(S): MiRNA arrays were prepared from six EPF and six CPF...
March 28, 2018: Fertility and Sterility
https://www.readbyqxmd.com/read/29605298/micro124-mediated-ahr-expression-regulates-the-inflammatory-response-of-chronic-rhinosinusitis-crs-with-nasal-polyps
#13
C C Liu, M Xia, Y J Zhang, P Jin, L Zhao, J Zhang, T Li, X M Zhou, Y Y Tu, F Kong, C Sun, L Shi, M Q Zhao
MicroRNAs represent a component of the innate immune responses that can restrain inflammatory signaling, miR124 is an important member of inflammation-associated miRNAs, and abnormal miR124 expression is observed in many inflammatory diseases and immune disorders. However, the role and signaling pathways of miR124 in chronic rhinosinusitis with nasal polyps (CRSwNPs) have not been studied in detail. The aryl hydrocarbon receptor (AHR) is a ligand-inducible transcription factor that is highly conserved in evolution and plays important roles in the inflammatory response process...
March 29, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29593734/experimental-demyelination-and-axonal-loss-are-reduced-in-microrna-146a-deficient-mice
#14
Nellie A Martin, Viktor Molnar, Gabor T Szilagyi, Maria L Elkjaer, Arkadiusz Nawrocki, Justyna Okarmus, Agnieszka Wlodarczyk, Eva K Thygesen, Miklos Palkovits, Ferenc Gallyas, Martin R Larsen, Hans Lassmann, Eirikur Benedikz, Trevor Owens, Asa F Svenningsen, Zsolt Illes
Background: The cuprizone (CPZ) model of multiple sclerosis (MS) was used to identify microRNAs (miRNAs) related to in vivo de- and remyelination. We further investigated the role of miR-146a in miR-146a-deficient (KO) mice: this miRNA is differentially expressed in MS lesions and promotes differentiation of oligodendrocyte precursor cells (OPCs) during remyelination, but its role has not been examined during demyelination. Methods: MicroRNAs were examined by Agilent Mouse miRNA Microarray in the corpus callosum during CPZ-induced demyelination and remyelination...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29582620/is-herv-k-and-herv-w-expression-regulated-by-mir-155-in-s%C3%A3-zary-syndrome
#15
Massimiliano Bergallo, Valentina Daprà, Mauro Novelli, Marco Rassu, Paola Montanari, Ilaria Galliano, Pietro Quaglino, Maria T Fierro
BACKGROUND: According to the latest update, 2578 unique mature miRNAs are currently annotated in the human genome and participate in the regulation of multiple events, such as cellular proliferation or apoptosis. A previous study analyzing global miRNA expression patterns in GH cells (high HERV-K versus low) showed that two miRNAs (miR-663 and miR-638) are differentially regulated and exhibit expression parallel to that of HERV-K. The aim of this study was to evaluate HERV-K and -W pol gene and mir-155 expression in SS patients and possible relationship between them...
March 26, 2018: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/29578533/microrna-663-induces-immune-dysregulation-by-inhibiting-tgf-%C3%AE-1-production-in-bone-marrow-derived-mesenchymal-stem-cells-in-patients-with-systemic-lupus-erythematosus
#16
Linyu Geng, Xiaojun Tang, Kangxing Zhou, Dandan Wang, Shiying Wang, Genhong Yao, Weiwei Chen, Xiang Gao, Wanjun Chen, Songtao Shi, Nan Shen, Xuebing Feng, Lingyun Sun
Mesenchymal stem cells (MSCs) are critical for immune regulation. Although several microRNAs (miRNAs) have been shown to participate in autoimmune pathogenesis by affecting lymphocyte development and function, the roles of miRNAs in MSC dysfunction in autoimmune diseases remain unclear. Here, we show that patients with systemic lupus erythematosus (SLE) display a unique miRNA signature in bone marrow-derived MSCs (BMSCs) compared with normal controls, among which miR-663 is closely associated with SLE disease activity...
March 26, 2018: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/29578163/upregulation-of-mir-371-373-cluster-a-human-embryonic-stem-cell-specific-microrna-cluster-in-esophageal-squamous-cell-carcinoma
#17
Masoumeh Ghasemi, Nader Mansour Samaei, Seyed Javad Mowla, Mohammad Shafiee, Mohammad Vasei, Nadia Ghasemian
Aims: Esophageal squamous cell carcinoma (ESCC) is the most common subtype of esophageal cancer in Iran. MicroRNAs (miRNAs) are a class of noncoding RNAs that are found to be involved in different processes and can play a role in tumorigenesis and result in cancer. MiR-371, miR-372, and miR-373 are a gene cluster that is located in the region of the human chromosome of 19q13.4. They are specifically expressed in human embryonic stem cells (ESCs) and involved in the maintenance of the stemness features through regulating the expression of certain key genes and signaling pathways...
2018: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/29575551/a-28-day-sub-acute-genotoxic-and-behavioural-assessment-of-garcinielliptone-fc
#18
Vanessa R Coelho, Lismare S Prado, Raíssa R Rossato, Alexandre B F Ferraz, Caroline G Vieira, Luana P de Souza, Pricila Pfluger, Gabriela G Regner, Marina T C Valle, Mirna B Leal, Eliane Dallegrave, Dione S Corrêa, Jaqueline N Picada, Patrícia Pereira
Garcinielliptone FC (GFC) is a polyisoprenilated benzophenone isolated from Platonia insignis Mart (Clusiaceae) with promising anticonvulsant properties. However, its safe use and other effects on the central nervous system require assessment. This study assessed the toxicological effects of GFC using the comet assay and the micronucleus test in mice treated for 28 days. A behavioural model was employed to detect possible injuries on the central nervous system. Mice treated with GFC (2, 10 and 20 mg/kg; i.p...
March 24, 2018: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/29574754/microrna-dependent-regulation-of-klf4-by-glucose-in-vascular-smooth-muscle
#19
Tran T Hien, Eliana Garcia-Vaz, Karin G Stenkula, Johan Sjögren, Johan Nilsson, Maria F Gomez, Sebastian Albinsson
Diabetes is a major risk factor for cardiovascular disease and this is in part due to the effects of hyperglycemia on vascular smooth muscle cells. Small non-coding microRNAs are known to control smooth muscle phenotype and arterial contractility and are dysregulated in diabetes. The effect of microRNAs on smooth muscle differentiation is in part mediated by the transcription factor KLF4 but the role of this mechanism in diabetic vascular disease is not fully understood. Herein, we have investigated the importance of hyperglycemia and diabetes for the expression of KLF4 in vascular smooth muscle and the involvement of miRNAs in this regulation...
March 25, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29570251/tumor-derived-exosomes-modulate-t-cell-function-through-transfer-of-rna
#20
Imran G House, Emma V Petley, Paul A Beavis
Tumor cells can develop a variety of mechanisms to evade and subvert the immune system for their survival. Bland et al., in this edition of The FEBS Journal, make the novel finding that the tumor line B16F0 can deliver mRNA/miRNA loaded exosomes to cytotoxic T lymphocytes and alter their metabolic function and interferon gamma production.
March 2018: FEBS Journal
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